Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
Identifieur interne : 000542 ( PubMed/Corpus ); précédent : 000541; suivant : 000543Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
Auteurs : P G Kremsner ; S. Neifer ; M F Chaves ; R. Rudolph ; U. BienzleSource :
- European journal of immunology [ 0014-2980 ] ; 1992.
English descriptors
- KwdEn :
- Animals, Arginine (analogs & derivatives), Arginine (pharmacology), Chloroquine (therapeutic use), Deferoxamine (pharmacology), Female, Immunization, Interferon-gamma (toxicity), Liver (pathology), Malaria (drug therapy), Malaria (pathology), Mice, Mice, Inbred BALB C, Pentoxifylline (pharmacology), Tumor Necrosis Factor-alpha (physiology), omega-N-Methylarginine.
- MESH :
- chemical , analogs & derivatives : Arginine.
- chemical , pharmacology : Arginine, Deferoxamine, Pentoxifylline.
- chemical , physiology : Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Chloroquine.
- chemical , toxicity : Interferon-gamma.
- drug therapy : Malaria.
- pathology : Liver, Malaria.
- Animals, Female, Immunization, Mice, Mice, Inbred BALB C, omega-N-Methylarginine.
Abstract
A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice. When mice were treated with three times 300 micrograms chloroquine at 24-h intervals starting at a parasitemia of 30%-50%, only 5 of 14 mice (36%) died 2-4 days after initiation of therapy. However, when infected mice received chloroquine plus 1 microgram IFN-gamma at the same time, 14 of 18 mice (78%) died 0.5-3 days after start of therapy (p < 0.05) despite clearance of parasitemia. The histopathology from mice dying after combination therapy revealed interstitial leukocyte infiltration of lung tissue, severe liver cell necrosis and kidney tubular necrosis. Pretreatment of P. vinckei-infected mice with pentoxifylline, a phosphodiesterase inhibitor, led to a significant decrease of IFN-gamma-induced lethality (p < 0.05). In contrast, pretreatment with neutralizing antibodies to tumor necrosis factor or with L-N-monomethyl arginine, the latter an inhibitor of the nitric oxide synthase, significantly increased lethality (p < 0.05).
DOI: 10.1002/eji.1830221118
PubMed: 1425913
Links to Exploration step
pubmed:1425913Le document en format XML
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Bienzle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1425913</idno><idno type="pmid">1425913</idno><idno type="doi">10.1002/eji.1830221118</idno><idno type="wicri:Area/PubMed/Corpus">000542</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.</title><author><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P G" last="Kremsner">P G Kremsner</name><affiliation><nlm:affiliation>Landesinstitut für Tropenmedizin Berlin, Freie Universität Berlin, FRG.</nlm:affiliation></affiliation></author><author><name sortKey="Neifer, S" sort="Neifer, S" uniqKey="Neifer S" first="S" last="Neifer">S. Neifer</name></author><author><name sortKey="Chaves, M F" sort="Chaves, M F" uniqKey="Chaves M" first="M F" last="Chaves">M F Chaves</name></author><author><name sortKey="Rudolph, R" sort="Rudolph, R" uniqKey="Rudolph R" first="R" last="Rudolph">R. Rudolph</name></author><author><name sortKey="Bienzle, U" sort="Bienzle, U" uniqKey="Bienzle U" first="U" last="Bienzle">U. Bienzle</name></author></analytic><series><title level="j">European journal of immunology</title><idno type="ISSN">0014-2980</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Arginine (analogs & derivatives)</term><term>Arginine (pharmacology)</term><term>Chloroquine (therapeutic use)</term><term>Deferoxamine (pharmacology)</term><term>Female</term><term>Immunization</term><term>Interferon-gamma (toxicity)</term><term>Liver (pathology)</term><term>Malaria (drug therapy)</term><term>Malaria (pathology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Pentoxifylline (pharmacology)</term><term>Tumor Necrosis Factor-alpha (physiology)</term><term>omega-N-Methylarginine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Arginine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Arginine</term><term>Deferoxamine</term><term>Pentoxifylline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term><term>Malaria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Immunization</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>omega-N-Methylarginine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice. When mice were treated with three times 300 micrograms chloroquine at 24-h intervals starting at a parasitemia of 30%-50%, only 5 of 14 mice (36%) died 2-4 days after initiation of therapy. However, when infected mice received chloroquine plus 1 microgram IFN-gamma at the same time, 14 of 18 mice (78%) died 0.5-3 days after start of therapy (p < 0.05) despite clearance of parasitemia. The histopathology from mice dying after combination therapy revealed interstitial leukocyte infiltration of lung tissue, severe liver cell necrosis and kidney tubular necrosis. Pretreatment of P. vinckei-infected mice with pentoxifylline, a phosphodiesterase inhibitor, led to a significant decrease of IFN-gamma-induced lethality (p < 0.05). In contrast, pretreatment with neutralizing antibodies to tumor necrosis factor or with L-N-monomethyl arginine, the latter an inhibitor of the nitric oxide synthase, significantly increased lethality (p < 0.05).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1425913</PMID><DateCompleted><Year>1992</Year><Month>12</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-2980</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>11</Issue><PubDate><Year>1992</Year><Month>Nov</Month></PubDate></JournalIssue><Title>European journal of immunology</Title><ISOAbbreviation>Eur. J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.</ArticleTitle><Pagination><MedlinePgn>2873-8</MedlinePgn></Pagination><Abstract><AbstractText>A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice. When mice were treated with three times 300 micrograms chloroquine at 24-h intervals starting at a parasitemia of 30%-50%, only 5 of 14 mice (36%) died 2-4 days after initiation of therapy. However, when infected mice received chloroquine plus 1 microgram IFN-gamma at the same time, 14 of 18 mice (78%) died 0.5-3 days after start of therapy (p < 0.05) despite clearance of parasitemia. The histopathology from mice dying after combination therapy revealed interstitial leukocyte infiltration of lung tissue, severe liver cell necrosis and kidney tubular necrosis. Pretreatment of P. vinckei-infected mice with pentoxifylline, a phosphodiesterase inhibitor, led to a significant decrease of IFN-gamma-induced lethality (p < 0.05). In contrast, pretreatment with neutralizing antibodies to tumor necrosis factor or with L-N-monomethyl arginine, the latter an inhibitor of the nitric oxide synthase, significantly increased lethality (p < 0.05).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kremsner</LastName><ForeName>P G</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Landesinstitut für Tropenmedizin Berlin, Freie Universität Berlin, FRG.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neifer</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Chaves</LastName><ForeName>M F</ForeName><Initials>MF</Initials></Author><Author ValidYN="Y"><LastName>Rudolph</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Bienzle</LastName><ForeName>U</ForeName><Initials>U</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Immunol</MedlineTA><NlmUniqueID>1273201</NlmUniqueID><ISSNLinking>0014-2980</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>27JT06E6GR</RegistryNumber><NameOfSubstance UI="D019323">omega-N-Methylarginine</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>94ZLA3W45F</RegistryNumber><NameOfSubstance UI="D001120">Arginine</NameOfSubstance></Chemical><Chemical><RegistryNumber>J06Y7MXW4D</RegistryNumber><NameOfSubstance UI="D003676">Deferoxamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>SD6QCT3TSU</RegistryNumber><NameOfSubstance UI="D010431">Pentoxifylline</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001120" MajorTopicYN="N">Arginine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003676" MajorTopicYN="N">Deferoxamine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007114" MajorTopicYN="N">Immunization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010431" MajorTopicYN="N">Pentoxifylline</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019323" MajorTopicYN="N">omega-N-Methylarginine</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>11</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>11</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>11</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1425913</ArticleId><ArticleId 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