Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.
Identifieur interne : 000505 ( PubMed/Corpus ); précédent : 000504; suivant : 000506Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.
Auteurs : R. Vatti ; O P SharmaSource :
- Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG [ 1124-0490 ] ; 1997.
English descriptors
- KwdEn :
- Adult, Aged, Alkaline Phosphatase (metabolism), Antirheumatic Agents (therapeutic use), Chloroquine (therapeutic use), Diagnosis, Differential, Disease Progression, Female, Follow-Up Studies, Glucocorticoids (adverse effects), Glucocorticoids (therapeutic use), Humans, Incidence, Liver Diseases (diagnosis), Liver Diseases (drug therapy), Liver Diseases (enzymology), Liver Function Tests, Male, Middle Aged, Retrospective Studies, Sarcoidosis (diagnosis), Sarcoidosis (drug therapy), Sarcoidosis (enzymology), Transaminases (metabolism).
- MESH :
- chemical , adverse effects : Glucocorticoids.
- chemical , metabolism : Alkaline Phosphatase, Transaminases.
- chemical , therapeutic use : Antirheumatic Agents, Chloroquine, Glucocorticoids.
- diagnosis : Liver Diseases, Sarcoidosis.
- drug therapy : Liver Diseases, Sarcoidosis.
- enzymology : Liver Diseases, Sarcoidosis.
- Adult, Aged, Diagnosis, Differential, Disease Progression, Female, Follow-Up Studies, Humans, Incidence, Liver Function Tests, Male, Middle Aged, Retrospective Studies.
Abstract
Although granulomatous involvement of the liver with functional abnormalities is widely known, the course of these abnormalities is not clearly known. The study was designed to find out the incidence and course of asymptomatic liver function abnormalities.
PubMed: 9186992
Links to Exploration step
pubmed:9186992Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.</title><author><name sortKey="Vatti, R" sort="Vatti, R" uniqKey="Vatti R" first="R" last="Vatti">R. Vatti</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O P" last="Sharma">O P Sharma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9186992</idno><idno type="pmid">9186992</idno><idno type="wicri:Area/PubMed/Corpus">000505</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000505</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.</title><author><name sortKey="Vatti, R" sort="Vatti, R" uniqKey="Vatti R" first="R" last="Vatti">R. Vatti</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O P" last="Sharma">O P Sharma</name></author></analytic><series><title level="j">Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG</title><idno type="ISSN">1124-0490</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alkaline Phosphatase (metabolism)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Chloroquine (therapeutic use)</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Glucocorticoids (adverse effects)</term><term>Glucocorticoids (therapeutic use)</term><term>Humans</term><term>Incidence</term><term>Liver Diseases (diagnosis)</term><term>Liver Diseases (drug therapy)</term><term>Liver Diseases (enzymology)</term><term>Liver Function Tests</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Sarcoidosis (diagnosis)</term><term>Sarcoidosis (drug therapy)</term><term>Sarcoidosis (enzymology)</term><term>Transaminases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Glucocorticoids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Alkaline Phosphatase</term><term>Transaminases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term><term>Chloroquine</term><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Liver Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Liver Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Liver Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Incidence</term><term>Liver Function Tests</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although granulomatous involvement of the liver with functional abnormalities is widely known, the course of these abnormalities is not clearly known. The study was designed to find out the incidence and course of asymptomatic liver function abnormalities.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9186992</PMID><DateCompleted><Year>1997</Year><Month>07</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1124-0490</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>1997</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG</Title><ISOAbbreviation>Sarcoidosis Vasc Diffuse Lung Dis</ISOAbbreviation></Journal><ArticleTitle>Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.</ArticleTitle><Pagination><MedlinePgn>73-6</MedlinePgn></Pagination><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Although granulomatous involvement of the liver with functional abnormalities is widely known, the course of these abnormalities is not clearly known. The study was designed to find out the incidence and course of asymptomatic liver function abnormalities.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">From 1990-1995, during the five year period, 44 (35.2%) of 125 patients with sarcoidosis at LAC + USC Medical Center had liver involvement. Liver enzyme abnormalities aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (AP) were taken as criteria for liver involvement: 41 (93%) patients had elevated AP, 22 (50%) showed elevated ALT, and 24 (54.5%) had elevated AST.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">25 of 44 patients received treatment; 12 (48%) showed improvement in liver enzymes and 13 (52%) remained unchanged. Ten (7%) of 13 patients, who did not receive any treatment, also improved. During the same period at USC University Hospital 18 (25%) of 72 had liver involvement. Twelve patients received treatment; 6 (50%) patients showed improvement in liver enzymes. One of 3 patients, who did not receive treatment, improved. 5 (41%) developed complications due to steroids.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Liver involvement is common in African American patients with sarcoidosis. Social and economic status do not seem to influence the liver involvement. In men the age distribution has an early peak. The outcome of patients who receive treatment remains similar, as far as liver function is concerned, suggesting that most of the patients with liver involvement undergo natural remission. Unless the patient has progressive liver dysfunction, it is advisable to monitor liver enzymes periodically and obtain liver biopsies only if clinically indicated. In patients who need treatment, it is reasonable to try options other than steroids in view of severe corticosteroid related complications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vatti</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>O P</ForeName><Initials>OP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Sarcoidosis Vasc Diffuse Lung Dis</MedlineTA><NlmUniqueID>9610928</NlmUniqueID><ISSNLinking>1124-0490</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.-</RegistryNumber><NameOfSubstance UI="D000637">Transaminases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.1</RegistryNumber><NameOfSubstance UI="D000469">Alkaline Phosphatase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000469" MajorTopicYN="N">Alkaline Phosphatase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008107" MajorTopicYN="N">Liver Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008111" MajorTopicYN="N">Liver Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012507" MajorTopicYN="N">Sarcoidosis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000637" MajorTopicYN="N">Transaminases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>3</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9186992</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000505 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000505 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:9186992
|texte= Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:9186992" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |