Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.
Identifieur interne : 000399 ( PubMed/Corpus ); précédent : 000398; suivant : 000400Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.
Auteurs : Kahunu Mesia ; Richard K. Cimanga ; Liene Dhooghe ; Paul Cos ; Sandra Apers ; Jozef Totté ; Gaston L. Tona ; Luc Pieters ; Arnold J. Vlietinck ; Louis MaesSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2010.
English descriptors
- KwdEn :
- Animals, Antimalarials (isolation & purification), Antimalarials (toxicity), Cells, Cultured, Drug Evaluation, Preclinical (methods), Female, Humans, Mice, Plant Bark, Plant Extracts (isolation & purification), Plant Extracts (toxicity), Plant Stems, Plasmodium falciparum (drug effects), Plasmodium falciparum (growth & development), Random Allocation, Rubiaceae, Toxicity Tests, Acute (methods).
- MESH :
- chemical , isolation & purification : Antimalarials, Plant Extracts.
- chemical , toxicity : Antimalarials, Plant Extracts.
- drug effects : Plasmodium falciparum.
- growth & development : Plasmodium falciparum.
- methods : Drug Evaluation, Preclinical, Toxicity Tests, Acute.
- Animals, Cells, Cultured, Female, Humans, Mice, Plant Bark, Plant Stems, Random Allocation, Rubiaceae.
Abstract
To evaluate the in vitro and in vivo antiplasmodial activity and toxicity of the aqueous and 80% EtOH extract of the stem bark of Nauclea pobeguinii (Pob. Ex. Pell.) Petit (Rubiaceae), a plant used in traditional medicine in DR Congo against malaria.
DOI: 10.1016/j.jep.2010.05.008
PubMed: 20470876
Links to Exploration step
pubmed:20470876Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.</title><author><name sortKey="Mesia, Kahunu" sort="Mesia, Kahunu" uniqKey="Mesia K" first="Kahunu" last="Mesia">Kahunu Mesia</name><affiliation><nlm:affiliation>Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of the Congo.</nlm:affiliation></affiliation></author><author><name sortKey="Cimanga, Richard K" sort="Cimanga, Richard K" uniqKey="Cimanga R" first="Richard K" last="Cimanga">Richard K. Cimanga</name></author><author><name sortKey="Dhooghe, Liene" sort="Dhooghe, Liene" uniqKey="Dhooghe L" first="Liene" last="Dhooghe">Liene Dhooghe</name></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name></author><author><name sortKey="Apers, Sandra" sort="Apers, Sandra" uniqKey="Apers S" first="Sandra" last="Apers">Sandra Apers</name></author><author><name sortKey="Totte, Jozef" sort="Totte, Jozef" uniqKey="Totte J" first="Jozef" last="Totté">Jozef Totté</name></author><author><name sortKey="Tona, Gaston L" sort="Tona, Gaston L" uniqKey="Tona G" first="Gaston L" last="Tona">Gaston L. Tona</name></author><author><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name></author><author><name sortKey="Vlietinck, Arnold J" sort="Vlietinck, Arnold J" uniqKey="Vlietinck A" first="Arnold J" last="Vlietinck">Arnold J. Vlietinck</name></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20470876</idno><idno type="pmid">20470876</idno><idno type="doi">10.1016/j.jep.2010.05.008</idno><idno type="wicri:Area/PubMed/Corpus">000399</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000399</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.</title><author><name sortKey="Mesia, Kahunu" sort="Mesia, Kahunu" uniqKey="Mesia K" first="Kahunu" last="Mesia">Kahunu Mesia</name><affiliation><nlm:affiliation>Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of the Congo.</nlm:affiliation></affiliation></author><author><name sortKey="Cimanga, Richard K" sort="Cimanga, Richard K" uniqKey="Cimanga R" first="Richard K" last="Cimanga">Richard K. Cimanga</name></author><author><name sortKey="Dhooghe, Liene" sort="Dhooghe, Liene" uniqKey="Dhooghe L" first="Liene" last="Dhooghe">Liene Dhooghe</name></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name></author><author><name sortKey="Apers, Sandra" sort="Apers, Sandra" uniqKey="Apers S" first="Sandra" last="Apers">Sandra Apers</name></author><author><name sortKey="Totte, Jozef" sort="Totte, Jozef" uniqKey="Totte J" first="Jozef" last="Totté">Jozef Totté</name></author><author><name sortKey="Tona, Gaston L" sort="Tona, Gaston L" uniqKey="Tona G" first="Gaston L" last="Tona">Gaston L. Tona</name></author><author><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name></author><author><name sortKey="Vlietinck, Arnold J" sort="Vlietinck, Arnold J" uniqKey="Vlietinck A" first="Arnold J" last="Vlietinck">Arnold J. Vlietinck</name></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antimalarials (isolation & purification)</term><term>Antimalarials (toxicity)</term><term>Cells, Cultured</term><term>Drug Evaluation, Preclinical (methods)</term><term>Female</term><term>Humans</term><term>Mice</term><term>Plant Bark</term><term>Plant Extracts (isolation & purification)</term><term>Plant Extracts (toxicity)</term><term>Plant Stems</term><term>Plasmodium falciparum (drug effects)</term><term>Plasmodium falciparum (growth & development)</term><term>Random Allocation</term><term>Rubiaceae</term><term>Toxicity Tests, Acute (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antimalarials</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antimalarials</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Evaluation, Preclinical</term><term>Toxicity Tests, Acute</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Mice</term><term>Plant Bark</term><term>Plant Stems</term><term>Random Allocation</term><term>Rubiaceae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the in vitro and in vivo antiplasmodial activity and toxicity of the aqueous and 80% EtOH extract of the stem bark of Nauclea pobeguinii (Pob. Ex. Pell.) Petit (Rubiaceae), a plant used in traditional medicine in DR Congo against malaria.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20470876</PMID><DateCompleted><Year>2011</Year><Month>05</Month><Day>27</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>131</Volume><Issue>1</Issue><PubDate><Year>2010</Year><Month>Aug</Month><Day>19</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.</ArticleTitle><Pagination><MedlinePgn>10-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2010.05.008</ELocationID><Abstract><AbstractText Label="AIM OF THE STUDY" NlmCategory="OBJECTIVE">To evaluate the in vitro and in vivo antiplasmodial activity and toxicity of the aqueous and 80% EtOH extract of the stem bark of Nauclea pobeguinii (Pob. Ex. Pell.) Petit (Rubiaceae), a plant used in traditional medicine in DR Congo against malaria.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The aqueous and 80% EtOH extract from N. pobeguinii stem bark, and its constituents (5S)-5-carboxystrictosidine, 19-O-methylangustoline, 3-O-beta-fucosylquinovic acid, 3-ketoquinovic acid and strictosamide, were evaluated for their in vitro activity against Plasmodium falciparum (chloroquine-sensitive Ghana-strain). The 80% EtOH extract, containing 5.6% strictosamide, was evaluated in vivo in the 4-day P. berghei mouse model, and in the P. yoelii N67 model.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">All compounds were inactive or only moderately active in vitro. The aqueous and 80% EtOH extract displayed moderate in vitro activity with IC(50) values of 44 and 32 microg/mL, respectively, without apparent cytotoxicity on MRC-5 cells (CC50>64 microg/mL). Daily oral dosing of the 80% EtOH extract, at 300 mg/kg, resulted in 86% reduction of parasitaemia in the 4-day P. berghei mouse model, and 75% reduction in the P. yoelii N67 model. Prolonging oral dosing to 2 x 5 days, with an interval of 2 days, and oral administration of the 80% EtOH extract at 300 mg/kg induced 92% reduction of parasitaemia, and a mean survival time of 17 days. Strictosamide, the putative active constituent, may be metabolically activated in the gastrointestinal tract after oral administration. Levels of creatinin, urea, ALAT and ASAT remained unchanged after treatment. No acute toxicity was observed in mice after a single 2g/kg oral dose, nor after 4 weekly doses. No significant macroscopic or microscopic lesions were observed in heart, lung, spleen, kidney, liver, large intestine and brain.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results can partly support and justify the use of N. pobeguinii in traditional medicine in the DR Congo for the treatment of uncomplicated malaria.</AbstractText><CopyrightInformation>(c) 2010 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mesia</LastName><ForeName>Kahunu</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of the Congo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cimanga</LastName><ForeName>Richard K</ForeName><Initials>RK</Initials></Author><Author ValidYN="Y"><LastName>Dhooghe</LastName><ForeName>Liene</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Cos</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Apers</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Totté</LastName><ForeName>Jozef</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Tona</LastName><ForeName>Gaston L</ForeName><Initials>GL</Initials></Author><Author ValidYN="Y"><LastName>Pieters</LastName><ForeName>Luc</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Vlietinck</LastName><ForeName>Arnold J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Maes</LastName><ForeName>Louis</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>05</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004353" MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024301" MajorTopicYN="N">Plant Bark</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018547" MajorTopicYN="N">Plant Stems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019666" MajorTopicYN="Y">Rubiaceae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023382" MajorTopicYN="N">Toxicity Tests, Acute</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>05</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>5</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20470876</ArticleId><ArticleId IdType="pii">S0378-8741(10)00308-9</ArticleId><ArticleId IdType="doi">10.1016/j.jep.2010.05.008</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000399 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000399 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:20470876
|texte= Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:20470876" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |