Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel.
Identifieur interne : 000328 ( PubMed/Corpus ); précédent : 000327; suivant : 000329Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel.
Auteurs : Haijun Yu ; Zhiai Xu ; Xianzhi Chen ; Leilei Xu ; Qi Yin ; Zhiwen Zhang ; Yaping LiSource :
- Macromolecular bioscience [ 1616-5195 ] ; 2014.
English descriptors
- KwdEn :
- Antineoplastic Agents, Phytogenic (administration & dosage), Antineoplastic Agents, Phytogenic (pharmacology), Apoptosis (drug effects), Apoptosis (genetics), Cell Line, Tumor, Chloroquine (pharmacology), Drug Carriers, Drug Resistance, Multiple (drug effects), Drug Resistance, Multiple (genetics), Drug Resistance, Neoplasm (drug effects), Drug Resistance, Neoplasm (genetics), Gene Knockdown Techniques, Humans, Hydrogen-Ion Concentration, Luciferases (genetics), Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (pathology), Macrolides (pharmacology), Micelles, Nanoparticles (administration & dosage), Nanoparticles (chemistry), Paclitaxel (administration & dosage), Paclitaxel (pharmacology), Polymethacrylic Acids, Proto-Oncogene Proteins c-bcl-2 (genetics), RNA, Small Interfering (administration & dosage), RNA, Small Interfering (genetics), Transfection.
- MESH :
- chemical , administration & dosage : Antineoplastic Agents, Phytogenic, Paclitaxel, RNA, Small Interfering.
- chemical , genetics : Luciferases, Proto-Oncogene Proteins c-bcl-2, RNA, Small Interfering.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Chloroquine, Macrolides, Paclitaxel.
- administration & dosage : Nanoparticles.
- chemistry : Nanoparticles.
- drug effects : Apoptosis, Drug Resistance, Multiple, Drug Resistance, Neoplasm.
- drug therapy : Lung Neoplasms.
- genetics : Apoptosis, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Lung Neoplasms.
- pathology : Lung Neoplasms.
- Cell Line, Tumor, Drug Carriers, Gene Knockdown Techniques, Humans, Hydrogen-Ion Concentration, Micelles, Polymethacrylic Acids, Transfection.
Abstract
The recent advances in RNA interference (RNAi) technology provided novel and promising solutions for human cancer treatment. In this study, the application of dual pH-responsive cationic micellar nanoparticles for small interfering RNA (siRNA) and paclitaxel (PTX) co-delivery to overcome cancer multidrug resistance (MDR) is reported. The in vitro siRNA transfection shows that siRNA-luciferase (Luc) loaded micelleplexes efficiently silences Luc expression in various carcinoma cell lines. The Luc knockdown ability of the micelleplexes can be enhanced by choloquine (CQ) co-incubation. However, is abolished by bafilomycin-A1 (Baf-A1) treatment. The micelleplexes are further exploited for co-delivery of siRNA-Bcl-2 and PTX to Bcl-2 overexpressing A549 lung cancer cells (A549-Bcl-2). The experimental results show that the micelleplexes could sensitize A549-Bcl-2 cells to PTX via down-regulation of anti-apoptosis gene of Bcl-2, suggesting that PDMA-b-PDPA micelleplexes are promising nanovectors for siRNA and anti-cancer drug co-delivery to overcome cancer MDR.
DOI: 10.1002/mabi.201300282
PubMed: 23966347
Links to Exploration step
pubmed:23966347Le document en format XML
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<author><name sortKey="Chen, Xianzhi" sort="Chen, Xianzhi" uniqKey="Chen X" first="Xianzhi" last="Chen">Xianzhi Chen</name>
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<author><name sortKey="Zhang, Zhiwen" sort="Zhang, Zhiwen" uniqKey="Zhang Z" first="Zhiwen" last="Zhang">Zhiwen Zhang</name>
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<term>Apoptosis (genetics)</term>
<term>Cell Line, Tumor</term>
<term>Chloroquine (pharmacology)</term>
<term>Drug Carriers</term>
<term>Drug Resistance, Multiple (drug effects)</term>
<term>Drug Resistance, Multiple (genetics)</term>
<term>Drug Resistance, Neoplasm (drug effects)</term>
<term>Drug Resistance, Neoplasm (genetics)</term>
<term>Gene Knockdown Techniques</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Luciferases (genetics)</term>
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<term>Lung Neoplasms (genetics)</term>
<term>Lung Neoplasms (pathology)</term>
<term>Macrolides (pharmacology)</term>
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<term>Nanoparticles (administration & dosage)</term>
<term>Nanoparticles (chemistry)</term>
<term>Paclitaxel (administration & dosage)</term>
<term>Paclitaxel (pharmacology)</term>
<term>Polymethacrylic Acids</term>
<term>Proto-Oncogene Proteins c-bcl-2 (genetics)</term>
<term>RNA, Small Interfering (administration & dosage)</term>
<term>RNA, Small Interfering (genetics)</term>
<term>Transfection</term>
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<term>RNA, Small Interfering</term>
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<term>Proto-Oncogene Proteins c-bcl-2</term>
<term>RNA, Small Interfering</term>
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<term>Paclitaxel</term>
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<term>Drug Resistance, Multiple</term>
<term>Drug Resistance, Neoplasm</term>
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<term>Gene Knockdown Techniques</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Micelles</term>
<term>Polymethacrylic Acids</term>
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<front><div type="abstract" xml:lang="en">The recent advances in RNA interference (RNAi) technology provided novel and promising solutions for human cancer treatment. In this study, the application of dual pH-responsive cationic micellar nanoparticles for small interfering RNA (siRNA) and paclitaxel (PTX) co-delivery to overcome cancer multidrug resistance (MDR) is reported. The in vitro siRNA transfection shows that siRNA-luciferase (Luc) loaded micelleplexes efficiently silences Luc expression in various carcinoma cell lines. The Luc knockdown ability of the micelleplexes can be enhanced by choloquine (CQ) co-incubation. However, is abolished by bafilomycin-A1 (Baf-A1) treatment. The micelleplexes are further exploited for co-delivery of siRNA-Bcl-2 and PTX to Bcl-2 overexpressing A549 lung cancer cells (A549-Bcl-2). The experimental results show that the micelleplexes could sensitize A549-Bcl-2 cells to PTX via down-regulation of anti-apoptosis gene of Bcl-2, suggesting that PDMA-b-PDPA micelleplexes are promising nanovectors for siRNA and anti-cancer drug co-delivery to overcome cancer MDR. </div>
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<Abstract><AbstractText>The recent advances in RNA interference (RNAi) technology provided novel and promising solutions for human cancer treatment. In this study, the application of dual pH-responsive cationic micellar nanoparticles for small interfering RNA (siRNA) and paclitaxel (PTX) co-delivery to overcome cancer multidrug resistance (MDR) is reported. The in vitro siRNA transfection shows that siRNA-luciferase (Luc) loaded micelleplexes efficiently silences Luc expression in various carcinoma cell lines. The Luc knockdown ability of the micelleplexes can be enhanced by choloquine (CQ) co-incubation. However, is abolished by bafilomycin-A1 (Baf-A1) treatment. The micelleplexes are further exploited for co-delivery of siRNA-Bcl-2 and PTX to Bcl-2 overexpressing A549 lung cancer cells (A549-Bcl-2). The experimental results show that the micelleplexes could sensitize A549-Bcl-2 cells to PTX via down-regulation of anti-apoptosis gene of Bcl-2, suggesting that PDMA-b-PDPA micelleplexes are promising nanovectors for siRNA and anti-cancer drug co-delivery to overcome cancer MDR. </AbstractText>
<CopyrightInformation>© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation>
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