Increased risk of mycobacterial infections associated with anti-rheumatic medications.
Identifieur interne : 000257 ( PubMed/Corpus ); précédent : 000256; suivant : 000258Increased risk of mycobacterial infections associated with anti-rheumatic medications.
Auteurs : Sarah K. Brode ; Frances B. Jamieson ; Ryan Ng ; Michael A. Campitelli ; Jeffrey C. Kwong ; J Michael Paterson ; Ping Li ; Alex Marchand-Austin ; Claire Bombardier ; Theodore K. MarrasSource :
- Thorax [ 1468-3296 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antirheumatic Agents (adverse effects), Arthritis, Rheumatoid (complications), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (epidemiology), Case-Control Studies, Databases, Factual, Drug Utilization (statistics & numerical data), Female, Humans, Immunosuppressive Agents (therapeutic use), Male, Mycobacterium Infections, Nontuberculous (chemically induced), Mycobacterium Infections, Nontuberculous (complications), Mycobacterium Infections, Nontuberculous (epidemiology), Ontario (epidemiology), Opportunistic Infections (chemically induced), Opportunistic Infections (complications), Opportunistic Infections (epidemiology), Risk Assessment (methods), Tuberculosis (chemically induced), Tuberculosis (complications), Tuberculosis (epidemiology), Tumor Necrosis Factor-alpha (antagonists & inhibitors).
- MESH :
- chemical , adverse effects : Antirheumatic Agents.
- chemical , antagonists & inhibitors : Tumor Necrosis Factor-alpha.
- geographic , epidemiology : Ontario.
- chemically induced : Mycobacterium Infections, Nontuberculous, Opportunistic Infections, Tuberculosis.
- complications : Arthritis, Rheumatoid, Mycobacterium Infections, Nontuberculous, Opportunistic Infections, Tuberculosis.
- drug therapy : Arthritis, Rheumatoid.
- epidemiology : Arthritis, Rheumatoid, Mycobacterium Infections, Nontuberculous, Opportunistic Infections, Tuberculosis.
- methods : Risk Assessment.
- statistics & numerical data : Drug Utilization.
- chemical , therapeutic use : Immunosuppressive Agents.
- Aged, Aged, 80 and over, Case-Control Studies, Databases, Factual, Female, Humans, Male.
Abstract
Anti-tumour necrosis factor (TNF) agents and other anti-rheumatic medications increase the risk of TB in rheumatoid arthritis (RA). Whether they increase the risk of infections with nontuberculous mycobacteria (NTM) is uncertain.
DOI: 10.1136/thoraxjnl-2014-206470
PubMed: 25911222
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pubmed:25911222Le document en format XML
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Jamieson</name><affiliation><nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Ryan" sort="Ng, Ryan" uniqKey="Ng R" first="Ryan" last="Ng">Ryan Ng</name><affiliation><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Campitelli, Michael A" sort="Campitelli, Michael A" uniqKey="Campitelli M" first="Michael A" last="Campitelli">Michael A. Campitelli</name><affiliation><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. 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Marras</name><affiliation><nlm:affiliation>Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25911222</idno><idno type="pmid">25911222</idno><idno type="doi">10.1136/thoraxjnl-2014-206470</idno><idno type="wicri:Area/PubMed/Corpus">000257</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000257</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increased risk of mycobacterial infections associated with anti-rheumatic medications.</title><author><name sortKey="Brode, Sarah K" sort="Brode, Sarah K" uniqKey="Brode S" first="Sarah K" last="Brode">Sarah K. Brode</name><affiliation><nlm:affiliation>Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada West Park Healthcare Centre, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jamieson, Frances B" sort="Jamieson, Frances B" uniqKey="Jamieson F" first="Frances B" last="Jamieson">Frances B. Jamieson</name><affiliation><nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Ryan" sort="Ng, Ryan" uniqKey="Ng R" first="Ryan" last="Ng">Ryan Ng</name><affiliation><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Campitelli, Michael A" sort="Campitelli, Michael A" uniqKey="Campitelli M" first="Michael A" last="Campitelli">Michael A. Campitelli</name><affiliation><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kwong, Jeffrey C" sort="Kwong, Jeffrey C" uniqKey="Kwong J" first="Jeffrey C" last="Kwong">Jeffrey C. Kwong</name><affiliation><nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada Toronto Western Family Health Team, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Paterson, J Michael" sort="Paterson, J Michael" uniqKey="Paterson J" first="J Michael" last="Paterson">J Michael Paterson</name><affiliation><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name><affiliation><nlm:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Marchand Austin, Alex" sort="Marchand Austin, Alex" uniqKey="Marchand Austin A" first="Alex" last="Marchand-Austin">Alex Marchand-Austin</name><affiliation><nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Bombardier, Claire" sort="Bombardier, Claire" uniqKey="Bombardier C" first="Claire" last="Bombardier">Claire Bombardier</name><affiliation><nlm:affiliation>Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Toronto General Hospital Research Institute, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Marras, Theodore K" sort="Marras, Theodore K" uniqKey="Marras T" first="Theodore K" last="Marras">Theodore K. Marras</name><affiliation><nlm:affiliation>Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Thorax</title><idno type="eISSN">1468-3296</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antirheumatic Agents (adverse effects)</term><term>Arthritis, Rheumatoid (complications)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (epidemiology)</term><term>Case-Control Studies</term><term>Databases, Factual</term><term>Drug Utilization (statistics & numerical data)</term><term>Female</term><term>Humans</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Male</term><term>Mycobacterium Infections, Nontuberculous (chemically induced)</term><term>Mycobacterium Infections, Nontuberculous (complications)</term><term>Mycobacterium Infections, Nontuberculous (epidemiology)</term><term>Ontario (epidemiology)</term><term>Opportunistic Infections (chemically induced)</term><term>Opportunistic Infections (complications)</term><term>Opportunistic Infections (epidemiology)</term><term>Risk Assessment (methods)</term><term>Tuberculosis (chemically induced)</term><term>Tuberculosis (complications)</term><term>Tuberculosis (epidemiology)</term><term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antirheumatic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Mycobacterium Infections, Nontuberculous</term><term>Opportunistic Infections</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Mycobacterium Infections, Nontuberculous</term><term>Opportunistic Infections</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Mycobacterium Infections, Nontuberculous</term><term>Opportunistic Infections</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Utilization</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Databases, Factual</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti-tumour necrosis factor (TNF) agents and other anti-rheumatic medications increase the risk of TB in rheumatoid arthritis (RA). Whether they increase the risk of infections with nontuberculous mycobacteria (NTM) is uncertain.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25911222</PMID><DateCompleted><Year>2015</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-3296</ISSN><JournalIssue CitedMedium="Internet"><Volume>70</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Thorax</Title><ISOAbbreviation>Thorax</ISOAbbreviation></Journal><ArticleTitle>Increased risk of mycobacterial infections associated with anti-rheumatic medications.</ArticleTitle><Pagination><MedlinePgn>677-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/thoraxjnl-2014-206470</ELocationID><Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Anti-tumour necrosis factor (TNF) agents and other anti-rheumatic medications increase the risk of TB in rheumatoid arthritis (RA). Whether they increase the risk of infections with nontuberculous mycobacteria (NTM) is uncertain.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine the effect of anti-TNF therapy and other anti-rheumatic drugs on the risk of NTM disease and TB in older patients with RA.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Population-based nested case-control study among Ontario seniors aged ≥67 years with RA who were prescribed at least one anti-rheumatic medication between 2001 and 2011. We identified cases of TB and NTM disease microbiologically and identified drug exposures using linked prescription drug claims. We estimated ORs using conditional logistic regression, controlling for several potential confounders.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Among 56 269 older adults with RA, we identified 37 cases of TB and 211 cases of NTM disease; each case was matched to up to 10 controls. Individuals with TB or NTM disease were both more likely to be using anti-TNF therapy (compared with non-use); adjusted ORs (95% CIs) were 5.04 (1.27 to 20.0) and 2.19 (1.10 to 4.37), respectively. Exposure to leflunomide and other anti-rheumatic drugs with high immunosuppressing potential also were associated with both TB and NTM disease, while oral corticosteroids and hydroxychloroquine were associated with NTM disease.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Anti-TNF use is associated with increased risk of both TB and NTM disease, but appears to be a relatively greater risk for TB. Several other anti-rheumatic drugs were also associated with mycobacterial infections.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brode</LastName><ForeName>Sarah K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada West Park Healthcare Centre, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamieson</LastName><ForeName>Frances B</ForeName><Initials>FB</Initials><AffiliationInfo><Affiliation>Public Health Ontario, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campitelli</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwong</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Public Health Ontario, Toronto, Ontario, Canada Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada Toronto Western Family Health Team, University Health Network, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paterson</LastName><ForeName>J Michael</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ping</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marchand-Austin</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Public Health Ontario, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bombardier</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada Toronto General Hospital Research Institute, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>Theodore K</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Joint Division of Respirology, Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Thorax</MedlineTA><NlmUniqueID>0417353</NlmUniqueID><ISSNLinking>0040-6376</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001172" MajorTopicYN="N">Arthritis, Rheumatoid</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016208" MajorTopicYN="N">Databases, Factual</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004363" MajorTopicYN="N">Drug Utilization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009165" MajorTopicYN="N">Mycobacterium Infections, Nontuberculous</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N" Type="Geographic">Ontario</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009894" MajorTopicYN="N">Opportunistic Infections</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014376" MajorTopicYN="N">Tuberculosis</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword 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