Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.
Identifieur interne : 000248 ( PubMed/Corpus ); précédent : 000247; suivant : 000249Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.
Auteurs : Ji-Hong Moon ; Seong Kug Eo ; John Hwa Lee ; Sang-Youel ParkSource :
- Oncology reports [ 1791-2431 ] ; 2015.
English descriptors
- KwdEn :
- Antineoplastic Agents (pharmacology), Autophagy (drug effects), Cell Line, Tumor, Chloroquine (pharmacology), Dose-Response Relationship, Drug, Gene Expression Regulation, Neoplastic (drug effects), Humans, Lung Neoplasms (metabolism), Microtubule-Associated Proteins (metabolism), Quercetin (pharmacology), RNA-Binding Proteins (metabolism), TNF-Related Apoptosis-Inducing Ligand (metabolism).
- MESH :
- chemical , metabolism : Microtubule-Associated Proteins, RNA-Binding Proteins, TNF-Related Apoptosis-Inducing Ligand.
- chemical , pharmacology : Antineoplastic Agents, Chloroquine, Quercetin.
- drug effects : Autophagy, Gene Expression Regulation, Neoplastic.
- metabolism : Lung Neoplasms.
- Cell Line, Tumor, Dose-Response Relationship, Drug, Humans.
Abstract
Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and the possible mechanism in human lung cancer cells. We identified that quercetin markedly enhanced TRAIL-mediated lung cancer cell death. Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B. Autophagy flux inhibitor, chloroquine treatment blocked the enhancing effects of TRAIL-induced apoptosis by quercetin. Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL.
DOI: 10.3892/or.2015.3991
PubMed: 25997470
Links to Exploration step
pubmed:25997470Le document en format XML
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Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Sang Youel" sort="Park, Sang Youel" uniqKey="Park S" first="Sang-Youel" last="Park">Sang-Youel Park</name><affiliation><nlm:affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25997470</idno><idno type="pmid">25997470</idno><idno type="doi">10.3892/or.2015.3991</idno><idno type="wicri:Area/PubMed/Corpus">000248</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000248</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.</title><author><name sortKey="Moon, Ji Hong" sort="Moon, Ji Hong" uniqKey="Moon J" first="Ji-Hong" last="Moon">Ji-Hong Moon</name><affiliation><nlm:affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Eo, Seong Kug" sort="Eo, Seong Kug" uniqKey="Eo S" first="Seong Kug" last="Eo">Seong Kug Eo</name><affiliation><nlm:affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, John Hwa" sort="Lee, John Hwa" uniqKey="Lee J" first="John Hwa" last="Lee">John Hwa Lee</name><affiliation><nlm:affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Sang Youel" sort="Park, Sang Youel" uniqKey="Park S" first="Sang-Youel" last="Park">Sang-Youel Park</name><affiliation><nlm:affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Oncology reports</title><idno type="eISSN">1791-2431</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (pharmacology)</term><term>Autophagy (drug effects)</term><term>Cell Line, Tumor</term><term>Chloroquine (pharmacology)</term><term>Dose-Response Relationship, Drug</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Humans</term><term>Lung Neoplasms (metabolism)</term><term>Microtubule-Associated Proteins (metabolism)</term><term>Quercetin (pharmacology)</term><term>RNA-Binding Proteins (metabolism)</term><term>TNF-Related Apoptosis-Inducing Ligand (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Microtubule-Associated Proteins</term><term>RNA-Binding Proteins</term><term>TNF-Related Apoptosis-Inducing Ligand</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Chloroquine</term><term>Quercetin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Gene Expression Regulation, Neoplastic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Dose-Response Relationship, Drug</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and the possible mechanism in human lung cancer cells. We identified that quercetin markedly enhanced TRAIL-mediated lung cancer cell death. Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B. Autophagy flux inhibitor, chloroquine treatment blocked the enhancing effects of TRAIL-induced apoptosis by quercetin. Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25997470</PMID><DateCompleted><Year>2016</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1791-2431</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Oncology reports</Title><ISOAbbreviation>Oncol. Rep.</ISOAbbreviation></Journal><ArticleTitle>Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death.</ArticleTitle><Pagination><MedlinePgn>375-81</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3892/or.2015.3991</ELocationID><Abstract><AbstractText>Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances TRAIL-induced tumor cell death and the possible mechanism in human lung cancer cells. We identified that quercetin markedly enhanced TRAIL-mediated lung cancer cell death. Quercetin treatment dose-dependently decreased the p62 protein expression and increased GFP-LC3B. Autophagy flux inhibitor, chloroquine treatment blocked the enhancing effects of TRAIL-induced apoptosis by quercetin. Our results indicated that quercetin enhanced TRAIL-induced cell death via autophagy flux activation, and also suggest that quercetin may be a therapeutic agent against human lung cancer via combination therapy with many anticancer drugs including TRAIL. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moon</LastName><ForeName>Ji-Hong</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eo</LastName><ForeName>Seong Kug</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>John Hwa</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Sang-Youel</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Biosafety Research Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Greece</Country><MedlineTA>Oncol Rep</MedlineTA><NlmUniqueID>9422756</NlmUniqueID><ISSNLinking>1021-335X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502070">MAP1LC3B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008869">Microtubule-Associated Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C118585">P62 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053221">TNF-Related Apoptosis-Inducing Ligand</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C505653">TNFSF10 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>9IKM0I5T1E</RegistryNumber><NameOfSubstance UI="D011794">Quercetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000494" 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