7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.
Identifieur interne : 000162 ( PubMed/Corpus ); précédent : 000161; suivant : 0001637-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.
Auteurs : En-Xia Wang ; Bo-Yang Zou ; Lei Shi ; Lin-Ying Du ; Yan-Yan Zhu ; Ya-Meng Jiang ; Xiao-Dong Ma ; Xiao-Hui Kang ; Chang-Yuan Wang ; Yu-Hong Zhen ; Li-Dan SunSource :
- Life sciences [ 1879-0631 ] ; 2017.
English descriptors
- KwdEn :
- Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Autophagy (drug effects), Carcinoma, Non-Small-Cell Lung (drug therapy), Carcinoma, Non-Small-Cell Lung (pathology), Cell Line, Cell Line, Tumor, Cell Survival (drug effects), Dose-Response Relationship, Drug, Fibroblasts (drug effects), Fibroblasts (metabolism), Flow Cytometry, Gene Expression Regulation, Neoplastic (drug effects), Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (pathology), Microscopy, Electron, Transmission, Quercetin (analogs & derivatives), Quercetin (pharmacology), Reactive Oxygen Species (metabolism), Time Factors.
- MESH :
- chemical , analogs & derivatives : Quercetin.
- chemical , metabolism : Reactive Oxygen Species.
- chemical , pharmacology : Antineoplastic Agents, Quercetin.
- drug effects : Apoptosis, Autophagy, Cell Survival, Fibroblasts, Gene Expression Regulation, Neoplastic.
- drug therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- metabolism : Fibroblasts.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Cell Line, Cell Line, Tumor, Dose-Response Relationship, Drug, Flow Cytometry, Humans, Microscopy, Electron, Transmission, Time Factors.
Abstract
To investigate the antitumor effects of 7-O-geranylquercetin (GQ), a novel O-alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms.
DOI: 10.1016/j.lfs.2017.05.008
PubMed: 28495516
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pubmed:28495516Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.</title><author><name sortKey="Wang, En Xia" sort="Wang, En Xia" uniqKey="Wang E" first="En-Xia" last="Wang">En-Xia Wang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zou, Bo Yang" sort="Zou, Bo Yang" uniqKey="Zou B" first="Bo-Yang" last="Zou">Bo-Yang Zou</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Du, Lin Ying" sort="Du, Lin Ying" uniqKey="Du L" first="Lin-Ying" last="Du">Lin-Ying Du</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Yan Yan" sort="Zhu, Yan Yan" uniqKey="Zhu Y" first="Yan-Yan" last="Zhu">Yan-Yan Zhu</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Ya Meng" sort="Jiang, Ya Meng" uniqKey="Jiang Y" first="Ya-Meng" last="Jiang">Ya-Meng Jiang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Xiao Dong" sort="Ma, Xiao Dong" uniqKey="Ma X" first="Xiao-Dong" last="Ma">Xiao-Dong Ma</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Xiao Hui" sort="Kang, Xiao Hui" uniqKey="Kang X" first="Xiao-Hui" last="Kang">Xiao-Hui Kang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Chang Yuan" sort="Wang, Chang Yuan" uniqKey="Wang C" first="Chang-Yuan" last="Wang">Chang-Yuan Wang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhen, Yu Hong" sort="Zhen, Yu Hong" uniqKey="Zhen Y" first="Yu-Hong" last="Zhen">Yu-Hong Zhen</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address: zhenyhwaner@aliyun.com.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Li Dan" sort="Sun, Li Dan" uniqKey="Sun L" first="Li-Dan" last="Sun">Li-Dan Sun</name><affiliation><nlm:affiliation>Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian 116001, China. Electronic address: 1804478893@qq.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28495516</idno><idno type="pmid">28495516</idno><idno type="doi">10.1016/j.lfs.2017.05.008</idno><idno type="wicri:Area/PubMed/Corpus">000162</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.</title><author><name sortKey="Wang, En Xia" sort="Wang, En Xia" uniqKey="Wang E" first="En-Xia" last="Wang">En-Xia Wang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zou, Bo Yang" sort="Zou, Bo Yang" uniqKey="Zou B" first="Bo-Yang" last="Zou">Bo-Yang Zou</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Du, Lin Ying" sort="Du, Lin Ying" uniqKey="Du L" first="Lin-Ying" last="Du">Lin-Ying Du</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Yan Yan" sort="Zhu, Yan Yan" uniqKey="Zhu Y" first="Yan-Yan" last="Zhu">Yan-Yan Zhu</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Ya Meng" sort="Jiang, Ya Meng" uniqKey="Jiang Y" first="Ya-Meng" last="Jiang">Ya-Meng Jiang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Xiao Dong" sort="Ma, Xiao Dong" uniqKey="Ma X" first="Xiao-Dong" last="Ma">Xiao-Dong Ma</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Xiao Hui" sort="Kang, Xiao Hui" uniqKey="Kang X" first="Xiao-Hui" last="Kang">Xiao-Hui Kang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Chang Yuan" sort="Wang, Chang Yuan" uniqKey="Wang C" first="Chang-Yuan" last="Wang">Chang-Yuan Wang</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhen, Yu Hong" sort="Zhen, Yu Hong" uniqKey="Zhen Y" first="Yu-Hong" last="Zhen">Yu-Hong Zhen</name><affiliation><nlm:affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address: zhenyhwaner@aliyun.com.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Li Dan" sort="Sun, Li Dan" uniqKey="Sun L" first="Li-Dan" last="Sun">Li-Dan Sun</name><affiliation><nlm:affiliation>Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian 116001, China. Electronic address: 1804478893@qq.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Life sciences</title><idno type="eISSN">1879-0631</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Autophagy (drug effects)</term><term>Carcinoma, Non-Small-Cell Lung (drug therapy)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Cell Line</term><term>Cell Line, Tumor</term><term>Cell Survival (drug effects)</term><term>Dose-Response Relationship, Drug</term><term>Fibroblasts (drug effects)</term><term>Fibroblasts (metabolism)</term><term>Flow Cytometry</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (pathology)</term><term>Microscopy, Electron, Transmission</term><term>Quercetin (analogs & derivatives)</term><term>Quercetin (pharmacology)</term><term>Reactive Oxygen Species (metabolism)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Quercetin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Quercetin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Autophagy</term><term>Cell Survival</term><term>Fibroblasts</term><term>Gene Expression Regulation, Neoplastic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fibroblasts</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Cell Line, Tumor</term><term>Dose-Response Relationship, Drug</term><term>Flow Cytometry</term><term>Humans</term><term>Microscopy, Electron, Transmission</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the antitumor effects of 7-O-geranylquercetin (GQ), a novel O-alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28495516</PMID><DateCompleted><Year>2017</Year><Month>06</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>06</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0631</ISSN><JournalIssue CitedMedium="Internet"><Volume>180</Volume><PubDate><Year>2017</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>Life sciences</Title><ISOAbbreviation>Life Sci.</ISOAbbreviation></Journal><ArticleTitle>7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.</ArticleTitle><Pagination><MedlinePgn>102-113</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0024-3205(17)30228-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.lfs.2017.05.008</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To investigate the antitumor effects of 7-O-geranylquercetin (GQ), a novel O-alkylated derivative of quercetin, against non-small cell lung cancer (NSCLC) cell lines A549 and NCI-H1975 and the corresponding mechanisms.</AbstractText><AbstractText Label="MAIN METHODS" NlmCategory="METHODS">Cell viability was assessed using MTT assay. The expression of proteins involved in apoptosis and autophagy was measured using western blotting. Besides, apoptosis was determined with DAPI staining, Annexin V-PI staining and transmission electron microscopy (TEM) assay, and autophagy was observed with TEM assay. Cell cycle and reactive oxygen species (ROS) level were detected using flow cytometry.</AbstractText><AbstractText Label="KEY FINDINGS" NlmCategory="RESULTS">GQ inhibited viability of A549 and NCI-H1975 cells in a dose- and time-dependent manner without apparent cytotoxicity to normal human lung fibroblast cells. GQ down-regulated the expression of apoptosis-related proteins pro-caspase 3 and Bcl-2, and up-regulated the expression of cleaved-PARP and Bax in A549 and NCI-H1975 cells. Meanwhile, GQ-induced cell apoptosis could be attenuated by caspase inhibitor Z-VAD-FMK. Besides, GQ induced autophagosome formation in A549 and NCI-H1975 cells, promoted the expression of autophagy-related proteins LC3-II and Beclin 1, and suppressed the expression of p62. Autophagy inhibition with chloroquine or Beclin 1 siRNA could effectively inhibit GQ-induced apoptosis. Furthermore, GQ treatment increased the generation of ROS, and ROS inhibitor N-acetylcysteine could reverse GQ-induced autophagy and apoptosis. Taken together, GQ could induce apoptosis and autophagy via ROS generation in A549 and NCI-H1975 cells, and GQ-induced autophagy contributed to apoptosis.</AbstractText><AbstractText Label="SIGNIFICANCE" NlmCategory="CONCLUSIONS">Our findings highlight that GQ is a promising anticancer agent for the treatment of lung cancer.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>En-Xia</ForeName><Initials>EX</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zou</LastName><ForeName>Bo-Yang</ForeName><Initials>BY</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Lin-Ying</ForeName><Initials>LY</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yan-Yan</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Ya-Meng</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Xiao-Dong</ForeName><Initials>XD</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Xiao-Hui</ForeName><Initials>XH</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Chang-Yuan</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhen</LastName><ForeName>Yu-Hong</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address: zhenyhwaner@aliyun.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Li-Dan</ForeName><Initials>LD</Initials><AffiliationInfo><Affiliation>Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian 116001, China. Electronic address: 1804478893@qq.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Life Sci</MedlineTA><NlmUniqueID>0375521</NlmUniqueID><ISSNLinking>0024-3205</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000607199">7-O-geranylquercetin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>9IKM0I5T1E</RegistryNumber><NameOfSubstance UI="D011794">Quercetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002289" MajorTopicYN="N">Carcinoma, Non-Small-Cell Lung</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011794" MajorTopicYN="N">Quercetin</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">7-O-geranylquercetin</Keyword><Keyword MajorTopicYN="N">Apoptosis</Keyword><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">Non-small cell lung cancer cells</Keyword><Keyword MajorTopicYN="N">Reactive oxygen species</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>04</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>05</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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