HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.
Identifieur interne : 000072 ( PubMed/Corpus ); précédent : 000071; suivant : 000073HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.
Auteurs : Yancho Zarev ; Kenn Foubert ; Paul Cos ; Louis Maes ; Esameldin Elgorashi ; Sandra Apers ; Iliana Ionkova ; Luc PietersSource :
- Natural product research [ 1478-6427 ] ; 2019.
Abstract
Seven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC50 6.53 µM and 4.05 µM, respectively), compared with the standard chloroquine (IC50 = 0.14 µM). No cytotoxicity was observed in a concentration up to 64.0 µM.
DOI: 10.1080/14786419.2018.1539976
PubMed: 30602319
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.</title><author><name sortKey="Zarev, Yancho" sort="Zarev, Yancho" uniqKey="Zarev Y" first="Yancho" last="Zarev">Yancho Zarev</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Foubert, Kenn" sort="Foubert, Kenn" uniqKey="Foubert K" first="Kenn" last="Foubert">Kenn Foubert</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name><affiliation><nlm:affiliation>c Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><affiliation><nlm:affiliation>c Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Elgorashi, Esameldin" sort="Elgorashi, Esameldin" uniqKey="Elgorashi E" first="Esameldin" last="Elgorashi">Esameldin Elgorashi</name><affiliation><nlm:affiliation>d Toxicology and Ethnoveterinary Medicine; Food, Feed and Veterinary Public Health , ARC-Onderstepoort Veterinary Institute , Onderstepoort , South-Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Apers, Sandra" sort="Apers, Sandra" uniqKey="Apers S" first="Sandra" last="Apers">Sandra Apers</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Ionkova, Iliana" sort="Ionkova, Iliana" uniqKey="Ionkova I" first="Iliana" last="Ionkova">Iliana Ionkova</name><affiliation><nlm:affiliation>b Department of Pharmacognosy, Faculty of Pharmacy , Medical University-Sofia , Sofia , Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30602319</idno><idno type="pmid">30602319</idno><idno type="doi">10.1080/14786419.2018.1539976</idno><idno type="wicri:Area/PubMed/Corpus">000072</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000072</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.</title><author><name sortKey="Zarev, Yancho" sort="Zarev, Yancho" uniqKey="Zarev Y" first="Yancho" last="Zarev">Yancho Zarev</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Foubert, Kenn" sort="Foubert, Kenn" uniqKey="Foubert K" first="Kenn" last="Foubert">Kenn Foubert</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name><affiliation><nlm:affiliation>c Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><affiliation><nlm:affiliation>c Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Elgorashi, Esameldin" sort="Elgorashi, Esameldin" uniqKey="Elgorashi E" first="Esameldin" last="Elgorashi">Esameldin Elgorashi</name><affiliation><nlm:affiliation>d Toxicology and Ethnoveterinary Medicine; Food, Feed and Veterinary Public Health , ARC-Onderstepoort Veterinary Institute , Onderstepoort , South-Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Apers, Sandra" sort="Apers, Sandra" uniqKey="Apers S" first="Sandra" last="Apers">Sandra Apers</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Ionkova, Iliana" sort="Ionkova, Iliana" uniqKey="Ionkova I" first="Iliana" last="Ionkova">Iliana Ionkova</name><affiliation><nlm:affiliation>b Department of Pharmacognosy, Faculty of Pharmacy , Medical University-Sofia , Sofia , Bulgaria.</nlm:affiliation></affiliation></author><author><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name><affiliation><nlm:affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Natural product research</title><idno type="eISSN">1478-6427</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Seven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC<sub>50</sub> 6.53 µM and 4.05 µM, respectively), compared with the standard chloroquine (IC<sub>50</sub> = 0.14 µM). No cytotoxicity was observed in a concentration up to 64.0 µM.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">30602319</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1478-6427</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2019</Year><Month>Jan</Month><Day>03</Day></PubDate></JournalIssue><Title>Natural product research</Title><ISOAbbreviation>Nat. Prod. Res.</ISOAbbreviation></Journal><ArticleTitle>HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.</ArticleTitle><Pagination><MedlinePgn>1-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14786419.2018.1539976</ELocationID><Abstract><AbstractText>Seven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC<sub>50</sub> 6.53 µM and 4.05 µM, respectively), compared with the standard chloroquine (IC<sub>50</sub> = 0.14 µM). No cytotoxicity was observed in a concentration up to 64.0 µM.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zarev</LastName><ForeName>Yancho</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Pharmacognosy, Faculty of Pharmacy , Medical University-Sofia , Sofia , Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foubert</LastName><ForeName>Kenn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cos</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>c Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences , University of Antwerp , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maes</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>c Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences , University of Antwerp , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elgorashi</LastName><ForeName>Esameldin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>d Toxicology and Ethnoveterinary Medicine; Food, Feed and Veterinary Public Health , ARC-Onderstepoort Veterinary Institute , Onderstepoort , South-Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Apers</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ionkova</LastName><ForeName>Iliana</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>b Department of Pharmacognosy, Faculty of Pharmacy , Medical University-Sofia , Sofia , Bulgaria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pieters</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>a Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences , University of Antwerp , Antwerp , Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Prod Res</MedlineTA><NlmUniqueID>101167924</NlmUniqueID><ISSNLinking>1478-6419</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Erythrina alkaloids</Keyword><Keyword MajorTopicYN="N">Erythrina latissima</Keyword><Keyword MajorTopicYN="N">HPLC-DAD-SPE-NMR</Keyword><Keyword MajorTopicYN="N">antiplasmodial activity</Keyword><Keyword MajorTopicYN="N">cytotoxicity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30602319</ArticleId><ArticleId IdType="doi">10.1080/14786419.2018.1539976</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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