Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.
Identifieur interne : 000046 ( PubMed/Corpus ); précédent : 000045; suivant : 000047Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.
Auteurs : Mitchell R. Dyer ; Wyeth Alexander ; Adnan Hassoune ; Qiwei Chen ; Tomasz Brzoska ; Jurgis Alvikas ; Yingjie Liu ; Shannon Haldeman ; Will Plautz ; Patricia Loughran ; Hui Li ; Brian Boone ; Yoel Sadovsky ; Prithu Sundd ; Brian S. Zuckerbraun ; Matthew D. NealSource :
- Journal of thrombosis and haemostasis : JTH [ 1538-7836 ] ; 2019.
Abstract
Traumatic injury can lead to dysregulation of the normal clotting system, resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following traumatic injury and one process of platelet activation is to release of extracellular vesicles (PEV) that carry heterogenous cargo loads and surface ligands.
DOI: 10.1111/jth.14563
PubMed: 31294514
Links to Exploration step
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.</title><author><name sortKey="Dyer, Mitchell R" sort="Dyer, Mitchell R" uniqKey="Dyer M" first="Mitchell R" last="Dyer">Mitchell R. Dyer</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Alexander, Wyeth" sort="Alexander, Wyeth" uniqKey="Alexander W" first="Wyeth" last="Alexander">Wyeth Alexander</name><affiliation><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Hassoune, Adnan" sort="Hassoune, Adnan" uniqKey="Hassoune A" first="Adnan" last="Hassoune">Adnan Hassoune</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Qiwei" sort="Chen, Qiwei" uniqKey="Chen Q" first="Qiwei" last="Chen">Qiwei Chen</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Brzoska, Tomasz" sort="Brzoska, Tomasz" uniqKey="Brzoska T" first="Tomasz" last="Brzoska">Tomasz Brzoska</name><affiliation><nlm:affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Alvikas, Jurgis" sort="Alvikas, Jurgis" uniqKey="Alvikas J" first="Jurgis" last="Alvikas">Jurgis Alvikas</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yingjie" sort="Liu, Yingjie" uniqKey="Liu Y" first="Yingjie" last="Liu">Yingjie Liu</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Haldeman, Shannon" sort="Haldeman, Shannon" uniqKey="Haldeman S" first="Shannon" last="Haldeman">Shannon Haldeman</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Plautz, Will" sort="Plautz, Will" uniqKey="Plautz W" first="Will" last="Plautz">Will Plautz</name><affiliation><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Loughran, Patricia" sort="Loughran, Patricia" uniqKey="Loughran P" first="Patricia" last="Loughran">Patricia Loughran</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Boone, Brian" sort="Boone, Brian" uniqKey="Boone B" first="Brian" last="Boone">Brian Boone</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Sadovsky, Yoel" sort="Sadovsky, Yoel" uniqKey="Sadovsky Y" first="Yoel" last="Sadovsky">Yoel Sadovsky</name><affiliation><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Sundd, Prithu" sort="Sundd, Prithu" uniqKey="Sundd P" first="Prithu" last="Sundd">Prithu Sundd</name><affiliation><nlm:affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Zuckerbraun, Brian S" sort="Zuckerbraun, Brian S" uniqKey="Zuckerbraun B" first="Brian S" last="Zuckerbraun">Brian S. Zuckerbraun</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Neal, Matthew D" sort="Neal, Matthew D" uniqKey="Neal M" first="Matthew D" last="Neal">Matthew D. Neal</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31294514</idno><idno type="pmid">31294514</idno><idno type="doi">10.1111/jth.14563</idno><idno type="wicri:Area/PubMed/Corpus">000046</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.</title><author><name sortKey="Dyer, Mitchell R" sort="Dyer, Mitchell R" uniqKey="Dyer M" first="Mitchell R" last="Dyer">Mitchell R. Dyer</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Alexander, Wyeth" sort="Alexander, Wyeth" uniqKey="Alexander W" first="Wyeth" last="Alexander">Wyeth Alexander</name><affiliation><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Hassoune, Adnan" sort="Hassoune, Adnan" uniqKey="Hassoune A" first="Adnan" last="Hassoune">Adnan Hassoune</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Qiwei" sort="Chen, Qiwei" uniqKey="Chen Q" first="Qiwei" last="Chen">Qiwei Chen</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Brzoska, Tomasz" sort="Brzoska, Tomasz" uniqKey="Brzoska T" first="Tomasz" last="Brzoska">Tomasz Brzoska</name><affiliation><nlm:affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Alvikas, Jurgis" sort="Alvikas, Jurgis" uniqKey="Alvikas J" first="Jurgis" last="Alvikas">Jurgis Alvikas</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yingjie" sort="Liu, Yingjie" uniqKey="Liu Y" first="Yingjie" last="Liu">Yingjie Liu</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Haldeman, Shannon" sort="Haldeman, Shannon" uniqKey="Haldeman S" first="Shannon" last="Haldeman">Shannon Haldeman</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Plautz, Will" sort="Plautz, Will" uniqKey="Plautz W" first="Will" last="Plautz">Will Plautz</name><affiliation><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Loughran, Patricia" sort="Loughran, Patricia" uniqKey="Loughran P" first="Patricia" last="Loughran">Patricia Loughran</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Boone, Brian" sort="Boone, Brian" uniqKey="Boone B" first="Brian" last="Boone">Brian Boone</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Sadovsky, Yoel" sort="Sadovsky, Yoel" uniqKey="Sadovsky Y" first="Yoel" last="Sadovsky">Yoel Sadovsky</name><affiliation><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Sundd, Prithu" sort="Sundd, Prithu" uniqKey="Sundd P" first="Prithu" last="Sundd">Prithu Sundd</name><affiliation><nlm:affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Zuckerbraun, Brian S" sort="Zuckerbraun, Brian S" uniqKey="Zuckerbraun B" first="Brian S" last="Zuckerbraun">Brian S. Zuckerbraun</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Neal, Matthew D" sort="Neal, Matthew D" uniqKey="Neal M" first="Matthew D" last="Neal">Matthew D. Neal</name><affiliation><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of thrombosis and haemostasis : JTH</title><idno type="eISSN">1538-7836</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Traumatic injury can lead to dysregulation of the normal clotting system, resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following traumatic injury and one process of platelet activation is to release of extracellular vesicles (PEV) that carry heterogenous cargo loads and surface ligands.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">31294514</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7836</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>10</Issue><PubDate><Year>2019</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of thrombosis and haemostasis : JTH</Title><ISOAbbreviation>J. Thromb. Haemost.</ISOAbbreviation></Journal><ArticleTitle>Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.</ArticleTitle><Pagination><MedlinePgn>1733-1745</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jth.14563</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Traumatic injury can lead to dysregulation of the normal clotting system, resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following traumatic injury and one process of platelet activation is to release of extracellular vesicles (PEV) that carry heterogenous cargo loads and surface ligands.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We sought to investigate and characterize the release and function of PEVs generated following traumatic injury.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">PEV content and quantity in circulation following trauma in humans and mice was measured using flow cytometry, size exclusion chromatography, and nanoparticle tracking analysis. PEVs were isolated from circulation and the effects on thrombin generation, bleeding time, hemorrhage control, and thrombus formation were determined. Finally, the effect of hydroxychloroquine (HCQ) on PEV release and thrombosis were examined.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Human and murine trauma results in a significant release of PEVs into circulation compared with healthy controls. These PEVs result in abundant thrombin generation, increased platelet aggregation, decreased bleeding times, and decreased hemorrhage in uncontrolled bleeding. Conversely, PEVs contributed to enhanced venous thrombus formation and were recruited to the developing thrombus site. Interestingly, HCQ treatment resulted in decreased platelet aggregation, decreased PEV release, and reduced deep vein thrombosis burden in mice.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These data demonstrate that trauma results in significant release of PEVs which are both pro-hemostatic and pro-thrombotic. The effects of PEVs can be mitigated by treatment with HCQ, suggesting the potential use as a form of deep vein thrombosis prophylaxis.</AbstractText><CopyrightInformation>© 2019 International Society on Thrombosis and Haemostasis.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dyer</LastName><ForeName>Mitchell R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alexander</LastName><ForeName>Wyeth</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hassoune</LastName><ForeName>Adnan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Qiwei</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brzoska</LastName><ForeName>Tomasz</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alvikas</LastName><ForeName>Jurgis</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yingjie</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haldeman</LastName><ForeName>Shannon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plautz</LastName><ForeName>Will</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loughran</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Biological Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Xiangya School of Medicine, Central South University, Changsha, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boone</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sadovsky</LastName><ForeName>Yoel</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sundd</LastName><ForeName>Prithu</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuckerbraun</LastName><ForeName>Brian S</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neal</LastName><ForeName>Matthew D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R35 GM119526-01</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1HL120877-01</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL128297</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>5T32GM008516</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL141080</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R35 GM119526</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM102146</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Thromb Haemost</MedlineTA><NlmUniqueID>101170508</NlmUniqueID><ISSNLinking>1538-7836</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">extracellular vesicles</Keyword><Keyword MajorTopicYN="N">hemorrhage</Keyword><Keyword MajorTopicYN="N">platelets</Keyword><Keyword MajorTopicYN="N">thrombosis</Keyword><Keyword MajorTopicYN="N">trauma</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>05</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>06</Month><Day>27</Day></PubMedPubDate><PubMedPubDate 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