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Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.

Identifieur interne : 000043 ( PubMed/Corpus ); précédent : 000042; suivant : 000044

Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.

Auteurs : Chengcheng Hao ; Guiping Liu ; Guangliang Tian

Source :

Therapeutic advances in respiratory disease [ 1753-4666 ]

RBID : pubmed:31368411

Abstract

Clinical treatment of non-small cell lung carcinoma (NSCLC) by cisplatin eventually results in drug resistance, which cancer stem cells and autophagy are believed to be involved in. In the present study, we aimed to explore the effect of autophagy-inhibited cancer stem cells in NSCLC.

DOI: 10.1177/1753466619866097
PubMed: 31368411

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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.</title>
<author><name sortKey="Hao, Chengcheng" sort="Hao, Chengcheng" uniqKey="Hao C" first="Chengcheng" last="Hao">Chengcheng Hao</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Guiping" sort="Liu, Guiping" uniqKey="Liu G" first="Guiping" last="Liu">Guiping Liu</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tian, Guangliang" sort="Tian, Guangliang" uniqKey="Tian G" first="Guangliang" last="Tian">Guangliang Tian</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, Liaocheng Cancer Hospital, No 45 Jianshe East Road, Liaocheng, Shandong, 252000, China.</nlm:affiliation>
</affiliation>
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<date when="????"><PubDate><MedlineDate>2019 Jan-Dec</MedlineDate>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.</title>
<author><name sortKey="Hao, Chengcheng" sort="Hao, Chengcheng" uniqKey="Hao C" first="Chengcheng" last="Hao">Chengcheng Hao</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Guiping" sort="Liu, Guiping" uniqKey="Liu G" first="Guiping" last="Liu">Guiping Liu</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tian, Guangliang" sort="Tian, Guangliang" uniqKey="Tian G" first="Guangliang" last="Tian">Guangliang Tian</name>
<affiliation><nlm:affiliation>Department of Radiation Oncology, Liaocheng Cancer Hospital, No 45 Jianshe East Road, Liaocheng, Shandong, 252000, China.</nlm:affiliation>
</affiliation>
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<series><title level="j">Therapeutic advances in respiratory disease</title>
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<front><div type="abstract" xml:lang="en">Clinical treatment of non-small cell lung carcinoma (NSCLC) by cisplatin eventually results in drug resistance, which cancer stem cells and autophagy are believed to be involved in. In the present study, we aimed to explore the effect of autophagy-inhibited cancer stem cells in NSCLC.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31368411</PMID>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1753-4666</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<PubDate><MedlineDate>2019 Jan-Dec</MedlineDate>
</PubDate>
</JournalIssue>
<Title>Therapeutic advances in respiratory disease</Title>
<ISOAbbreviation>Ther Adv Respir Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.</ArticleTitle>
<Pagination><MedlinePgn>1753466619866097</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1177/1753466619866097</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Clinical treatment of non-small cell lung carcinoma (NSCLC) by cisplatin eventually results in drug resistance, which cancer stem cells and autophagy are believed to be involved in. In the present study, we aimed to explore the effect of autophagy-inhibited cancer stem cells in NSCLC.</AbstractText>
<AbstractText Label="METHODS">Cancer stem cells were identified by CD133 expression levels detected by immunochemistry, real-time polymerase chain reaction, western blot, and flow cytometry. Stemness was detected by sphere-forming assays of tumor cells. Autophagy was determined by LC3-II expression at mRNA and protein levels. The effect of chloroquine (CQ) on autophagy was detected by real-time polymerase chain reaction, western blot and sphere-forming assay <i>in vitro</i>
, and tumor growth in male NOD/SCID mice.</AbstractText>
<AbstractText Label="RESULTS">Cisplatin (CDDP) treatment enhanced CD133<sup>+</sup>
 cell ratios in clinical NSCLC specimens and NSCLC cell line A549. The CD133<sup>+</sup>
 cells enriched by CDDP exhibited higher autophagy levels. Autophagy inhibition by CQ inhibited CD133<sup>+</sup>
 stemness and promoted CDDP efficiency in A549 cells. In addition, the combination of CDDP and CQ treatment significantly inhibited autophagy levels and cancer stem cell proportions <i>in vitro</i>
, and dramatically suppressed tumor growth compared with individual agents.</AbstractText>
<AbstractText Label="CONCLUSION">Autophagy inhibition of cancer stem cells could promote the efficacy of cisplatin against NSCLC.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hao</LastName>
<ForeName>Chengcheng</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Guiping</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, Liaocheng People's Hospital, Liaocheng, Shandong, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Guangliang</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">0000-0001-9464-8307</Identifier>
<AffiliationInfo><Affiliation>Department of Radiation Oncology, Liaocheng Cancer Hospital, No 45 Jianshe East Road, Liaocheng, Shandong, 252000, China.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Ther Adv Respir Dis</MedlineTA>
<NlmUniqueID>101316317</NlmUniqueID>
<ISSNLinking>1753-4658</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">autophagy</Keyword>
<Keyword MajorTopicYN="Y">cancer stem cell</Keyword>
<Keyword MajorTopicYN="Y">cisplatin</Keyword>
<Keyword MajorTopicYN="Y">non-small cell lung carcinoma</Keyword>
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Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.

Autophagy inhibition of cancer stem cells promotes the efficacy of cisplatin against non-small cell lung carcinoma.

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