Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists.
Identifieur interne : 000028 ( PubMed/Corpus ); précédent : 000027; suivant : 000029Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists.
Auteurs : Stanislas Grassin-Delyle ; Hélène Salvator ; Nikola Mantov ; Charlotte Abrial ; Marion Brollo ; Christophe Faisy ; Emmanuel Naline ; Louis-Jean Couderc ; Philippe DevillierSource :
- Frontiers in physiology [ 1664-042X ] ; 2019.
Abstract
Bitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also expressed in human blood leukocytes. We studied TAS2R expression and the effects of TAS2R agonists on the lipopolysaccharide (LPS)-induced cytokine release in human lung macrophages (LMs).
DOI: 10.3389/fphys.2019.01267
PubMed: 31632299
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists.</title><author><name sortKey="Grassin Delyle, Stanislas" sort="Grassin Delyle, Stanislas" uniqKey="Grassin Delyle S" first="Stanislas" last="Grassin-Delyle">Stanislas Grassin-Delyle</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Salvator, Helene" sort="Salvator, Helene" uniqKey="Salvator H" first="Hélène" last="Salvator">Hélène Salvator</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mantov, Nikola" sort="Mantov, Nikola" uniqKey="Mantov N" first="Nikola" last="Mantov">Nikola Mantov</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Abrial, Charlotte" sort="Abrial, Charlotte" uniqKey="Abrial C" first="Charlotte" last="Abrial">Charlotte Abrial</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brollo, Marion" sort="Brollo, Marion" uniqKey="Brollo M" first="Marion" last="Brollo">Marion Brollo</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Faisy, Christophe" sort="Faisy, Christophe" uniqKey="Faisy C" first="Christophe" last="Faisy">Christophe Faisy</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Naline, Emmanuel" sort="Naline, Emmanuel" uniqKey="Naline E" first="Emmanuel" last="Naline">Emmanuel Naline</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couderc, Louis Jean" sort="Couderc, Louis Jean" uniqKey="Couderc L" first="Louis-Jean" last="Couderc">Louis-Jean Couderc</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Devillier, Philippe" sort="Devillier, Philippe" uniqKey="Devillier P" first="Philippe" last="Devillier">Philippe Devillier</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31632299</idno><idno type="pmid">31632299</idno><idno type="doi">10.3389/fphys.2019.01267</idno><idno type="wicri:Area/PubMed/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000028</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists.</title><author><name sortKey="Grassin Delyle, Stanislas" sort="Grassin Delyle, Stanislas" uniqKey="Grassin Delyle S" first="Stanislas" last="Grassin-Delyle">Stanislas Grassin-Delyle</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Salvator, Helene" sort="Salvator, Helene" uniqKey="Salvator H" first="Hélène" last="Salvator">Hélène Salvator</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mantov, Nikola" sort="Mantov, Nikola" uniqKey="Mantov N" first="Nikola" last="Mantov">Nikola Mantov</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Abrial, Charlotte" sort="Abrial, Charlotte" uniqKey="Abrial C" first="Charlotte" last="Abrial">Charlotte Abrial</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brollo, Marion" sort="Brollo, Marion" uniqKey="Brollo M" first="Marion" last="Brollo">Marion Brollo</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Faisy, Christophe" sort="Faisy, Christophe" uniqKey="Faisy C" first="Christophe" last="Faisy">Christophe Faisy</name><affiliation><nlm:affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Naline, Emmanuel" sort="Naline, Emmanuel" uniqKey="Naline E" first="Emmanuel" last="Naline">Emmanuel Naline</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Couderc, Louis Jean" sort="Couderc, Louis Jean" uniqKey="Couderc L" first="Louis-Jean" last="Couderc">Louis-Jean Couderc</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Devillier, Philippe" sort="Devillier, Philippe" uniqKey="Devillier P" first="Philippe" last="Devillier">Philippe Devillier</name><affiliation><nlm:affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in physiology</title><idno type="ISSN">1664-042X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also expressed in human blood leukocytes. We studied TAS2R expression and the effects of TAS2R agonists on the lipopolysaccharide (LPS)-induced cytokine release in human lung macrophages (LMs).</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31632299</PMID><DateRevised><Year>2019</Year><Month>10</Month><Day>24</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-042X</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Frontiers in physiology</Title><ISOAbbreviation>Front Physiol</ISOAbbreviation></Journal><ArticleTitle>Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists.</ArticleTitle><Pagination><MedlinePgn>1267</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fphys.2019.01267</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Bitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also expressed in human blood leukocytes. We studied TAS2R expression and the effects of TAS2R agonists on the lipopolysaccharide (LPS)-induced cytokine release in human lung macrophages (LMs).</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">Lung macrophages were isolated from patients undergoing surgery for carcinoma. We used RT-qPCR to measure transcripts of 16 TAS2Rs (TAS2Rs 3/4/5/7/8/9/10/14/19/20/31/38/39/43/45 and 46) in unstimulated and LPS-stimulated (10 ng.mL<sup>-1</sup>) LMs. The macrophages were also incubated with TAS2R agonists for 24 h. Supernatant levels of the cytokines TNF-α, CCL3, CXCL8 and IL-10 were measured using ELISAs.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">The transcripts of all 16 TAS2Rs were detected in macrophages. The addition of LPS led to an increase in the expression of most TAS2Rs, which was significant for TAS2R7 and 38. Although the promiscuous TAS2R agonists, quinine and denatonium, inhibited the LPS-induced release of TNF-α, CCL3 and CXCL8, diphenidol was inactive. Partially selective agonists (dapsone, colchicine, strychnine, and chloroquine) and selective agonists [erythromycin (TAS2R10), phenanthroline (TAS2R5), ofloxacin (TAS2R9), and carisoprodol (TAS2R14)] also suppressed the LPS-induced cytokine release. In contrast, two other agonists [sodium cromoglycate (TAS2R20) and saccharin (TAS2R31 and 43)] were inactive. TAS2R agonists suppressed IL-10 production - suggesting that this anti-inflammatory cytokine is not involved in the inhibition of cytokine production.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Human LMs expressed TAS2Rs. Experiments with TAS2R agonists' suggested the involvement of TAS2Rs 3, 4, 5, 9, 10, 14, 30, 39 and 40 in the inhibition of cytokine production. TAS2Rs may constitute new drug targets in inflammatory obstructive lung disease.</AbstractText><CopyrightInformation>Copyright © 2019 Grassin-Delyle, Salvator, Mantov, Abrial, Brollo, Faisy, Naline, Couderc and Devillier.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grassin-Delyle</LastName><ForeName>Stanislas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR 1173, UFR Simone Veil - Santé, University Versailles Saint-Quentin, University of Paris-Saclay, Montigny-le-Bretonneux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salvator</LastName><ForeName>Hélène</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mantov</LastName><ForeName>Nikola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abrial</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brollo</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Faisy</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naline</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couderc</LastName><ForeName>Louis-Jean</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devillier</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Airway Diseases, Foch Hospital, Suresnes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Research in Respiratory Pharmacology-UPRES EA 220, Foch Hospital, University Versailles Saint-Quentin, University of Paris-Saclay, Suresnes, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType 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