A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level.
Identifieur interne : 000007 ( PubMed/Corpus ); précédent : 000006; suivant : 000008A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level.
Auteurs : Christopher Kwan ; Suzana Milosevic ; Helen Benham ; Ian A. ScottSource :
- BMJ case reports [ 1757-790X ] ; 2020.
Abstract
We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron's papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.
DOI: 10.1136/bcr-2019-232260
PubMed: 32033996
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pubmed:32033996Le document en format XML
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<affiliation><nlm:affiliation>Department of General Medicine, Princess Alexandra Hospital Health Service District, Brisbane, Queensland, Australia chriskwan88@gmail.com.</nlm:affiliation>
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<author><name sortKey="Milosevic, Suzana" sort="Milosevic, Suzana" uniqKey="Milosevic S" first="Suzana" last="Milosevic">Suzana Milosevic</name>
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<author><name sortKey="Benham, Helen" sort="Benham, Helen" uniqKey="Benham H" first="Helen" last="Benham">Helen Benham</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Princess Alexandra Hospital Health Service District, Brisbane, Queensland, Australia.</nlm:affiliation>
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<author><name sortKey="Scott, Ian A" sort="Scott, Ian A" uniqKey="Scott I" first="Ian A" last="Scott">Ian A. Scott</name>
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<front><div type="abstract" xml:lang="en">We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron's papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.</div>
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<Abstract><AbstractText>We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron's papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.</AbstractText>
<CopyrightInformation>© BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kwan</LastName>
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<CoiStatement>Competing interests: None declared.</CoiStatement>
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