Risk factors associated with mortality in systemic lupus erythematosus. A case-control study in a tertiary care center in Mexico City.
Identifieur interne : 000686 ( PubMed/Checkpoint ); précédent : 000685; suivant : 000687Risk factors associated with mortality in systemic lupus erythematosus. A case-control study in a tertiary care center in Mexico City.
Auteurs : B. Hernández-Cruz [Mexique] ; N. Tapia ; A R Villa-Romero ; E. Reyes ; M H CardielSource :
- Clinical and experimental rheumatology [ 0392-856X ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Cause de décès, Facteurs de risque, Femelle, Humains, Indice de gravité médicale, Lupus érythémateux disséminé (), Lupus érythémateux disséminé (mortalité), Lupus érythémateux disséminé (physiopathologie), Mexique (épidémiologie), Modèles logistiques, Mâle, Soins palliatifs, Sujet âgé, Études cas-témoins.
- MESH :
- mortalité : Lupus érythémateux disséminé.
- physiopathologie : Lupus érythémateux disséminé.
- épidémiologie : Mexique.
- Adolescent, Adulte, Adulte d'âge moyen, Cause de décès, Facteurs de risque, Femelle, Humains, Indice de gravité médicale, Lupus érythémateux disséminé, Modèles logistiques, Mâle, Soins palliatifs, Sujet âgé, Études cas-témoins.
- Wicri :
- geographic : Mexique.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Case-Control Studies, Cause of Death, Female, Humans, Logistic Models, Lupus Erythematosus, Systemic (complications), Lupus Erythematosus, Systemic (mortality), Lupus Erythematosus, Systemic (physiopathology), Male, Mexico (epidemiology), Middle Aged, Palliative Care, Risk Factors, Severity of Illness Index.
- MESH :
- geographic , epidemiology : Mexico.
- complications : Lupus Erythematosus, Systemic.
- mortality : Lupus Erythematosus, Systemic.
- physiopathology : Lupus Erythematosus, Systemic.
- Adolescent, Adult, Aged, Case-Control Studies, Cause of Death, Female, Humans, Logistic Models, Male, Middle Aged, Palliative Care, Risk Factors, Severity of Illness Index.
Abstract
To identify the mortality risk factors in a group of Mexican patients with SLE.
PubMed: 11491494
Affiliations:
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pubmed:11491494Le document en format XML
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Tapia</name></author><author><name sortKey="Villa Romero, A R" sort="Villa Romero, A R" uniqKey="Villa Romero A" first="A R" last="Villa-Romero">A R Villa-Romero</name></author><author><name sortKey="Reyes, E" sort="Reyes, E" uniqKey="Reyes E" first="E" last="Reyes">E. Reyes</name></author><author><name sortKey="Cardiel, M H" sort="Cardiel, M H" uniqKey="Cardiel M" first="M H" last="Cardiel">M H Cardiel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2001 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:11491494</idno><idno type="pmid">11491494</idno><idno type="wicri:Area/PubMed/Corpus">000474</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000474</idno><idno type="wicri:Area/PubMed/Curation">000474</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000474</idno><idno type="wicri:Area/PubMed/Checkpoint">000686</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000686</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk factors associated with mortality in systemic lupus erythematosus. A case-control study in a tertiary care center in Mexico City.</title><author><name sortKey="Hernandez Cruz, B" sort="Hernandez Cruz, B" uniqKey="Hernandez Cruz B" first="B" last="Hernández-Cruz">B. Hernández-Cruz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Tapia, N" sort="Tapia, N" uniqKey="Tapia N" first="N" last="Tapia">N. Tapia</name></author><author><name sortKey="Villa Romero, A R" sort="Villa Romero, A R" uniqKey="Villa Romero A" first="A R" last="Villa-Romero">A R Villa-Romero</name></author><author><name sortKey="Reyes, E" sort="Reyes, E" uniqKey="Reyes E" first="E" last="Reyes">E. Reyes</name></author><author><name sortKey="Cardiel, M H" sort="Cardiel, M H" uniqKey="Cardiel M" first="M H" last="Cardiel">M H Cardiel</name></author></analytic><series><title level="j">Clinical and experimental rheumatology</title><idno type="ISSN">0392-856X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Cause of Death</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Lupus Erythematosus, Systemic (complications)</term><term>Lupus Erythematosus, Systemic (mortality)</term><term>Lupus Erythematosus, Systemic (physiopathology)</term><term>Male</term><term>Mexico (epidemiology)</term><term>Middle Aged</term><term>Palliative Care</term><term>Risk Factors</term><term>Severity of Illness Index</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cause de décès</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Lupus érythémateux disséminé ()</term><term>Lupus érythémateux disséminé (mortalité)</term><term>Lupus érythémateux disséminé (physiopathologie)</term><term>Mexique (épidémiologie)</term><term>Modèles logistiques</term><term>Mâle</term><term>Soins palliatifs</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Mexico</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lupus Erythematosus, Systemic</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Lupus Erythematosus, Systemic</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Lupus érythémateux disséminé</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lupus érythémateux disséminé</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lupus Erythematosus, Systemic</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Mexique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Cause of Death</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Palliative Care</term><term>Risk Factors</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cause de décès</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Lupus érythémateux disséminé</term><term>Modèles logistiques</term><term>Mâle</term><term>Soins palliatifs</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Mexique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify the mortality risk factors in a group of Mexican patients with SLE.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11491494</PMID><DateCompleted><Year>2001</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0392-856X</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>4</Issue><PubDate><MedlineDate>2001 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>Clinical and experimental rheumatology</Title><ISOAbbreviation>Clin. Exp. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Risk factors associated with mortality in systemic lupus erythematosus. A case-control study in a tertiary care center in Mexico City.</ArticleTitle><Pagination><MedlinePgn>395-401</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To identify the mortality risk factors in a group of Mexican patients with SLE.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A case-control autopsy study in a tertiary care center in Mexico, City. Patients with SLE who died during 1958 to 1994 with an autopsy study were selected as cases, and alive patients matched by age (+/- 3 years), decade of SLE onset, and disease duration (+/- 5 years) were defined as controls. Clinical charts were reviewed looking at clinical variables. SLE disease activity was evaluated with the MexSledai index, and SLE disease severity with the Severity Index. Variables were classified as present at any moment during the follow-up and 3 months before death in cases or cut-off date in controls.</AbstractText><AbstractText Label="STATISTICAL ANALYSIS" NlmCategory="METHODS">matched univariate and multivariate analysis by multiple logistic regression were performed, and the results were presented as odds ratio and 95% confidence intervals (OR, 95%CI).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">76 matched pairs of patients were studied. Age, gender, and years offormal education were similar in the cases and controls. Variables associated with mortality three months before death were: lung involvement OR= 15.6, 95%CI (4.8-50.3), p<0.001; severe thrombocytopenia 9.6 (2.9-31.7), p<0.001; heart involvement 5.8 (2.6-13.0), p<0.001; and the severity index (cases 8.8 mu, 2.4 sigma vs controls 3.5, 2.0, respectively) 2.2 (1.5-3.4), p<0.001. Variables associated with mortality detected at any moment before death were kidney involvement 2.16 (1.09-4.29), p<0.02; the steroid therapeutic index 2.3 (1.2-4.5), p<0.001; number of previous admissions 2.4 (1.4-4.3), p<0.001; the MEX-SLEDAI index (cases 21.6 mu 6.3 sigma vs controls 12.6, 5.8), 1.2 (1.1-1.3), p<0.001; and the number of severe infections 14.4 (4.4-46.2), p<0.001. Protective variables were skin involvement 0.1 (0.3-0.6), p<0.001; daily dose of chloroquine (cases 3.9 mu, 24.1 sigma vs controls 39.4, 60.0 mg), p <0.0001 and the time from thefirst SLE symptom to the patient's demise or the cut-off date 0.7(0.6-0.9), p<0.001. Multiple logistic regression showed that the model which best explained mortality consisted of a severity index 2.6 (1.7-3.8), p<0.001; heart disease 6.5 (1.5-28.2), p=0.01, and steroid therapeutic index 3.3 (1.6-6.6), p=0.001.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">An active SLE with multi-organic involvement, steroids and infections were associated with mortality in Mexican patients with lupus attended in a tertiary care center A protective effect of cutaneous disease and chloroquine use was observed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hernández-Cruz</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tapia</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Villa-Romero</LastName><ForeName>A R</ForeName><Initials>AR</Initials></Author><Author ValidYN="Y"><LastName>Reyes</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Cardiel</LastName><ForeName>M H</ForeName><Initials>MH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Clin Exp Rheumatol</MedlineTA><NlmUniqueID>8308521</NlmUniqueID><ISSNLinking>0392-856X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002423" MajorTopicYN="N">Cause of Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008180" MajorTopicYN="N">Lupus Erythematosus, Systemic</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008800" MajorTopicYN="N" Type="Geographic">Mexico</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010166" MajorTopicYN="N">Palliative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>8</Month><Day>9</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>1</Month><Day>5</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>8</Month><Day>9</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11491494</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Mexique</li></country></list><tree><noCountry><name sortKey="Cardiel, M H" sort="Cardiel, M H" uniqKey="Cardiel M" first="M H" last="Cardiel">M H Cardiel</name><name sortKey="Reyes, E" sort="Reyes, E" uniqKey="Reyes E" first="E" last="Reyes">E. Reyes</name><name sortKey="Tapia, N" sort="Tapia, N" uniqKey="Tapia N" first="N" last="Tapia">N. Tapia</name><name sortKey="Villa Romero, A R" sort="Villa Romero, A R" uniqKey="Villa Romero A" first="A R" last="Villa-Romero">A R Villa-Romero</name></noCountry><country name="Mexique"><noRegion><name sortKey="Hernandez Cruz, B" sort="Hernandez Cruz, B" uniqKey="Hernandez Cruz B" first="B" last="Hernández-Cruz">B. Hernández-Cruz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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