Effectiveness of chloroquine and hydroxychloroquine in treating selected patients with sarcoidosis with neurological involvement.
Identifieur interne : 000479 ( PubMed/Checkpoint ); précédent : 000478; suivant : 000480Effectiveness of chloroquine and hydroxychloroquine in treating selected patients with sarcoidosis with neurological involvement.
Auteurs : O P Sharma [États-Unis]Source :
- Archives of neurology [ 0003-9942 ] ; 1998.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antipaludiques (effets indésirables), Antipaludiques (usage thérapeutique), Chloroquine (effets indésirables), Chloroquine (usage thérapeutique), Encéphale (anatomopathologie), Femelle, Humains, Hydroxychloroquine (usage thérapeutique), Imagerie par résonance magnétique, Maladies du système nerveux (anatomopathologie), Maladies du système nerveux (traitement médicamenteux), Mâle, Résultat thérapeutique, Sarcoïdose (anatomopathologie), Sarcoïdose (traitement médicamenteux), Études rétrospectives.
- MESH :
- anatomopathologie : Encéphale, Maladies du système nerveux, Sarcoïdose.
- effets indésirables : Antipaludiques, Chloroquine.
- traitement médicamenteux : Maladies du système nerveux, Sarcoïdose.
- usage thérapeutique : Antipaludiques, Chloroquine, Hydroxychloroquine.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Résultat thérapeutique, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Antimalarials (adverse effects), Antimalarials (therapeutic use), Brain (pathology), Chloroquine (adverse effects), Chloroquine (therapeutic use), Female, Humans, Hydroxychloroquine (therapeutic use), Magnetic Resonance Imaging, Male, Middle Aged, Nervous System Diseases (drug therapy), Nervous System Diseases (pathology), Retrospective Studies, Sarcoidosis (drug therapy), Sarcoidosis (pathology), Treatment Outcome.
- MESH :
- chemical , adverse effects : Antimalarials, Chloroquine.
- chemical , therapeutic use : Antimalarials, Chloroquine, Hydroxychloroquine.
- drug therapy : Nervous System Diseases, Sarcoidosis.
- pathology : Brain, Nervous System Diseases, Sarcoidosis.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Treatment Outcome.
Abstract
To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects.
DOI: 10.1001/archneur.55.9.1248
PubMed: 9740120
Affiliations:
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uniqKey="Sharma O" first="O P" last="Sharma">O P Sharma</name><affiliation wicri:level="4"><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, Los Angeles 90033, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, Los Angeles 90033</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><orgName type="university">Université de Californie du Sud</orgName><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Archives of neurology</title><idno type="ISSN">0003-9942</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antimalarials (adverse effects)</term><term>Antimalarials (therapeutic use)</term><term>Brain (pathology)</term><term>Chloroquine (adverse effects)</term><term>Chloroquine (therapeutic use)</term><term>Female</term><term>Humans</term><term>Hydroxychloroquine (therapeutic use)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nervous System Diseases (drug therapy)</term><term>Nervous System Diseases (pathology)</term><term>Retrospective Studies</term><term>Sarcoidosis (drug therapy)</term><term>Sarcoidosis (pathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antipaludiques (effets indésirables)</term><term>Antipaludiques (usage thérapeutique)</term><term>Chloroquine (effets indésirables)</term><term>Chloroquine (usage thérapeutique)</term><term>Encéphale (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Imagerie par résonance magnétique</term><term>Maladies du système nerveux (anatomopathologie)</term><term>Maladies du système nerveux (traitement médicamenteux)</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sarcoïdose (anatomopathologie)</term><term>Sarcoïdose (traitement médicamenteux)</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Maladies du système nerveux</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Nervous System Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Nervous System Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies du système nerveux</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9740120</PMID><DateCompleted><Year>1998</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0003-9942</ISSN><JournalIssue CitedMedium="Print"><Volume>55</Volume><Issue>9</Issue><PubDate><Year>1998</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Archives of neurology</Title><ISOAbbreviation>Arch. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of chloroquine and hydroxychloroquine in treating selected patients with sarcoidosis with neurological involvement.</ArticleTitle><Pagination><MedlinePgn>1248-54</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in the treatment of patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Sarcoidosis clinic at a university teaching hospital.</AbstractText><AbstractText Label="PATIENTS" NlmCategory="METHODS">Twelve patients with biopsy-proved sarcoidosis, 6 women and 6 men ranging from 20 to 49 years of age, with neurological involvement.</AbstractText><AbstractText Label="INTERVENTION" NlmCategory="METHODS">Chloroquine phosphate, 250 mg twice daily, or hydroxychloroquine sulfate, 200 mg twice daily, was administered for a period of 6 to 21 months. Patients had regular clinical evaluation, determination of serum and cerebrospinal fluid angiotensin-converting enzyme level, computed tomography or magnetic resonance imaging, chest radiography, lung function testing, and slit-lamp examination of the eyes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Chloroquine or hydroxychloroquine either stabilized symptoms or controlled neurological symptoms in 10 of 12 patients. Two patients failed to respond. Cerebrospinal fluid abnormalities, including lymphocytosis, were seen in 3 patients. Magnetic resonance imaging with gadolinium was most helpful in supporting the diagnosis of sarcoidosis and monitoring the course of the disease.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Chloroquine and hydroxychloroquine are effective in controlling neurological sarcoidosis in those patients who fail to respond to corticosteroids or develop severe side effects. Ocular toxic effects from chloroquine or hydroxychloroquine were not observed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>O P</ForeName><Initials>OP</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, Los Angeles 90033, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Neurol</MedlineTA><NlmUniqueID>0372436</NlmUniqueID><ISSNLinking>0003-9942</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012507" MajorTopicYN="N">Sarcoidosis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>9</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>9</Month><Day>18</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>9</Month><Day>18</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9740120</ArticleId><ArticleId IdType="doi">10.1001/archneur.55.9.1248</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Sharma, O P" sort="Sharma, O P" uniqKey="Sharma O" first="O P" last="Sharma">O P Sharma</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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