Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis.
Identifieur interne : 000428 ( PubMed/Checkpoint ); précédent : 000427; suivant : 000429Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis.
Auteurs : He-Shui Wu [République populaire de Chine] ; Lei Zhang ; Yan Chen ; Xing-Jun Guo ; Lin Wang ; Jian-Bo Xu ; Chun-You Wang ; Jing-Hui ZhangSource :
- Hepatobiliary & pancreatic diseases international : HBPD INT [ 1499-3872 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN messager (génétique), Amorces ADN, Animaux, Arginine (pharmacologie), Hémorragie (génétique), Hémorragie (physiopathologie), Inflammation, Monoxyde d'azote (usage thérapeutique), Mâle, Pancréatite aigüe nécrotique (génétique), Pancréatite aigüe nécrotique (physiopathologie), Poumon (), Poumon (anatomopathologie), RT-PCR, Rat Sprague-Dawley, Rats, Récepteur de type Toll-2 (génétique), Récepteur de type Toll-4 (génétique), Régulation de l'expression des gènes (), Séquence nucléotidique.
- MESH :
- anatomopathologie : Poumon.
- génétique : ARN messager, Hémorragie, Pancréatite aigüe nécrotique, Récepteur de type Toll-2, Récepteur de type Toll-4.
- pharmacologie : Arginine.
- physiopathologie : Hémorragie, Pancréatite aigüe nécrotique.
- usage thérapeutique : Monoxyde d'azote.
- Amorces ADN, Animaux, Inflammation, Mâle, Poumon, RT-PCR, Rat Sprague-Dawley, Rats, Régulation de l'expression des gènes, Séquence nucléotidique.
English descriptors
- KwdEn :
- Animals, Arginine (pharmacology), Base Sequence, DNA Primers, Gene Expression Regulation (drug effects), Hemorrhage (genetics), Hemorrhage (physiopathology), Inflammation, Lung (drug effects), Lung (pathology), Male, Nitric Oxide (therapeutic use), Pancreatitis, Acute Necrotizing (genetics), Pancreatitis, Acute Necrotizing (physiopathology), RNA, Messenger (genetics), Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Toll-Like Receptor 2 (genetics), Toll-Like Receptor 4 (genetics).
- MESH :
- chemical , genetics : RNA, Messenger, Toll-Like Receptor 2, Toll-Like Receptor 4.
- chemical , pharmacology : Arginine.
- drug effects : Gene Expression Regulation, Lung.
- genetics : Hemorrhage, Pancreatitis, Acute Necrotizing.
- pathology : Lung.
- physiopathology : Hemorrhage, Pancreatitis, Acute Necrotizing.
- chemical , therapeutic use : Nitric Oxide.
- Animals, Base Sequence, DNA Primers, Inflammation, Male, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Toll-like receptor (TLR) 2/4 might play important roles in mediating proinflammatory cytokine synthesis and release. And nitric oxide (NO) has been used to treat acute respiratory distress syndrome (ARDS). This study aimed to investigate the changes in TLR2/4 gene expression in the lungs of rats with acute lung injury (ALI) complicated by acute hemorrhage necrotizing pancreatitis (AHNP) and the effect of NO on the TLR2/4 gene expression.
PubMed: 16286274
Affiliations:
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pubmed:16286274Le document en format XML
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first="Lei" last="Zhang">Lei Zhang</name></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name></author><author><name sortKey="Guo, Xing Jun" sort="Guo, Xing Jun" uniqKey="Guo X" first="Xing-Jun" last="Guo">Xing-Jun Guo</name></author><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name></author><author><name sortKey="Xu, Jian Bo" sort="Xu, Jian Bo" uniqKey="Xu J" first="Jian-Bo" last="Xu">Jian-Bo Xu</name></author><author><name sortKey="Wang, Chun You" sort="Wang, Chun You" uniqKey="Wang C" first="Chun-You" last="Wang">Chun-You Wang</name></author><author><name sortKey="Zhang, Jing Hui" sort="Zhang, Jing Hui" uniqKey="Zhang J" first="Jing-Hui" last="Zhang">Jing-Hui Zhang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16286274</idno><idno type="pmid">16286274</idno><idno 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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Pancreatic Surgery, Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name></author><author><name sortKey="Guo, Xing Jun" sort="Guo, Xing Jun" uniqKey="Guo X" first="Xing-Jun" last="Guo">Xing-Jun Guo</name></author><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name></author><author><name sortKey="Xu, Jian Bo" sort="Xu, Jian Bo" uniqKey="Xu J" first="Jian-Bo" last="Xu">Jian-Bo Xu</name></author><author><name sortKey="Wang, Chun You" sort="Wang, Chun You" uniqKey="Wang C" first="Chun-You" last="Wang">Chun-You Wang</name></author><author><name sortKey="Zhang, Jing Hui" sort="Zhang, Jing Hui" uniqKey="Zhang J" first="Jing-Hui" last="Zhang">Jing-Hui Zhang</name></author></analytic><series><title level="j">Hepatobiliary & pancreatic diseases international : HBPD INT</title><idno type="ISSN">1499-3872</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Arginine (pharmacology)</term><term>Base Sequence</term><term>DNA Primers</term><term>Gene Expression Regulation (drug effects)</term><term>Hemorrhage (genetics)</term><term>Hemorrhage (physiopathology)</term><term>Inflammation</term><term>Lung (drug effects)</term><term>Lung (pathology)</term><term>Male</term><term>Nitric Oxide (therapeutic use)</term><term>Pancreatitis, Acute Necrotizing (genetics)</term><term>Pancreatitis, Acute Necrotizing (physiopathology)</term><term>RNA, Messenger (genetics)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Toll-Like Receptor 2 (genetics)</term><term>Toll-Like Receptor 4 (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>Amorces ADN</term><term>Animaux</term><term>Arginine (pharmacologie)</term><term>Hémorragie (génétique)</term><term>Hémorragie (physiopathologie)</term><term>Inflammation</term><term>Monoxyde d'azote (usage thérapeutique)</term><term>Mâle</term><term>Pancréatite aigüe nécrotique (génétique)</term><term>Pancréatite aigüe nécrotique (physiopathologie)</term><term>Poumon ()</term><term>Poumon (anatomopathologie)</term><term>RT-PCR</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Récepteur de type Toll-2 (génétique)</term><term>Récepteur de type Toll-4 (génétique)</term><term>Régulation de l'expression des gènes ()</term><term>Séquence nucléotidique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Messenger</term><term>Toll-Like Receptor 2</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Arginine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hemorrhage</term><term>Pancreatitis, Acute Necrotizing</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Hémorragie</term><term>Pancréatite aigüe nécrotique</term><term>Récepteur de type Toll-2</term><term>Récepteur de type Toll-4</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Arginine</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Hémorragie</term><term>Pancréatite aigüe nécrotique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hemorrhage</term><term>Pancreatitis, Acute Necrotizing</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Nitric Oxide</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Monoxyde d'azote</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Base Sequence</term><term>DNA Primers</term><term>Inflammation</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Amorces ADN</term><term>Animaux</term><term>Inflammation</term><term>Mâle</term><term>Poumon</term><term>RT-PCR</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Régulation de l'expression des gènes</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Toll-like receptor (TLR) 2/4 might play important roles in mediating proinflammatory cytokine synthesis and release. And nitric oxide (NO) has been used to treat acute respiratory distress syndrome (ARDS). This study aimed to investigate the changes in TLR2/4 gene expression in the lungs of rats with acute lung injury (ALI) complicated by acute hemorrhage necrotizing pancreatitis (AHNP) and the effect of NO on the TLR2/4 gene expression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16286274</PMID><DateCompleted><Year>2006</Year><Month>01</Month><Day>26</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1499-3872</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>4</Issue><PubDate><Year>2005</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Hepatobiliary & pancreatic diseases international : HBPD INT</Title><ISOAbbreviation>HBPD INT</ISOAbbreviation></Journal><ArticleTitle>Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis.</ArticleTitle><Pagination><MedlinePgn>609-13</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Toll-like receptor (TLR) 2/4 might play important roles in mediating proinflammatory cytokine synthesis and release. And nitric oxide (NO) has been used to treat acute respiratory distress syndrome (ARDS). This study aimed to investigate the changes in TLR2/4 gene expression in the lungs of rats with acute lung injury (ALI) complicated by acute hemorrhage necrotizing pancreatitis (AHNP) and the effect of NO on the TLR2/4 gene expression.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">One hundred and ten SD male rats were randomly divided into sham-operated group (n=10), AHNP group (n=30), chloroquine-treated group (n=30), and L-Arg-treated group (n=40). The lungs were dissected for lung histological scoring, and bronchoalveolar lavages were harvested for lung injury indexing. TLR2/4 mRNA expression in the lungs was measured by RT-PCR.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">TLR2/4mRNA was detected in the lungs with low values in the sham-operated group (0.016+/-0.210E-2, 0.112+/-0.750E-2), but it was markedly increased at 3 hours in the AHNP group (0.787+/-0.751E-2, 1.512+/-1.794E-2), peaking at 12 hours (1.113+/-6.141E-2, 2.957+/-2.620E-2; P<0.05 or P<0.01). When lung injuries were aggravated, TNF-alpha concentrations in the lungs were increased, but NO concentrations were decreased (P<0.05 or P<0.01). When TLR2/4mRNA was inhibited by CQ (3h: 0.313+/-5.491E-2, 0.005+/-1.419E-3; 6h: 0.488+/-7.442E-2, 0.010+/-1.518E-3; 12h: 0.883+/-8.911E-2, 0.024+/-2.760E-3; P<0.05 or P<0.01), lung injuries were relieved. NO concentrations in the lungs were increased but TNF-alpha concentrations were decreased (P<0.05 or P<0.01). When the rats with AHNP were treated with L-Arg, TLR2/4mRNA expression in the lungs could be effectively inhibited (50 mg-T: 0.656+/-3.977E-2, 1.501+/-6.111E-2; 100 mg-T: 0.260+/-0.891E-2, 0.732+/-5.135E-2; 200 mg-T: 0.126+/-0.914E-2, 0.414+/-1.678E-2; 400 mg-T: 0.091+/-0.399E-2, 0.287+/-0.176E-2;P<0.05 or P<0.01) and lung injuries were relieved. At the same time, NO concentrations in the lungs were markedly increased, but TNF-alpha concentrations were decreased (P<0.05 or P<0.01).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The expression of TLR2/4mRNA is increased in the lungs in rats with AHNP and lung injuries are aggravated.TLR2/4mRNA gene expression of the lungs of rats with AHNP could be markedly inhibited by NO, leading to the relief of lung injuries.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>He-Shui</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Center of Pancreatic Surgery, Affiliated Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lei</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Xing-Jun</ForeName><Initials>XJ</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lin</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Jian-Bo</ForeName><Initials>JB</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Chun-You</ForeName><Initials>CY</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jing-Hui</ForeName><Initials>JH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Singapore</Country><MedlineTA>Hepatobiliary Pancreat Dis Int</MedlineTA><NlmUniqueID>101151457</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017931">DNA Primers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495343">Tlr2 protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495347">Tlr4 protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051195">Toll-Like Receptor 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber><NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>94ZLA3W45F</RegistryNumber><NameOfSubstance UI="D001120">Arginine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001120" MajorTopicYN="N">Arginine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017931" MajorTopicYN="N">DNA Primers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006470" MajorTopicYN="N">Hemorrhage</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019283" MajorTopicYN="N">Pancreatitis, Acute Necrotizing</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051195" MajorTopicYN="N">Toll-Like Receptor 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>11</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>1</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>11</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16286274</ArticleId><ArticleId IdType="pii">770</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><noCountry><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Guo, Xing Jun" sort="Guo, Xing Jun" uniqKey="Guo X" first="Xing-Jun" last="Guo">Xing-Jun Guo</name><name sortKey="Wang, Chun You" sort="Wang, Chun You" uniqKey="Wang C" first="Chun-You" last="Wang">Chun-You Wang</name><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><name sortKey="Xu, Jian Bo" sort="Xu, Jian Bo" uniqKey="Xu J" first="Jian-Bo" last="Xu">Jian-Bo Xu</name><name sortKey="Zhang, Jing Hui" sort="Zhang, Jing Hui" uniqKey="Zhang J" first="Jing-Hui" last="Zhang">Jing-Hui Zhang</name><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Wu, He Shui" sort="Wu, He Shui" uniqKey="Wu H" first="He-Shui" last="Wu">He-Shui Wu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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