In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa.
Identifieur interne : 000366 ( PubMed/Checkpoint ); précédent : 000365; suivant : 000367In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa.
Auteurs : Jean Bernard Lekana-Douki [Gabon] ; Sandrine Lydie Oyegue Liabagui ; Jean Bernard Bongui ; Rafika Zatra ; Jacques Lebibi ; Fousseyni S. Toure-NdouoSource :
- BMC research notes [ 1756-0500 ] ; 2011.
Abstract
Malaria remains a major public health problem, especially in tropical and subtropical regions because of the emergence and widespread of antimalarial drug resistance. Traditional medicine represents one potential source of new treatments. Here, we investigated the in vitro antiplasmodial activity of bark extracts from two Fabaceae species (Tetrapleura tertaptera and Copaifera religiosa) traditionally used to treat malaria symptoms in Haut-Ogooué province, Gabon.
DOI: 10.1186/1756-0500-4-506
PubMed: 22112366
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Toure-Ndouo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22112366</idno><idno type="pmid">22112366</idno><idno type="doi">10.1186/1756-0500-4-506</idno><idno type="wicri:Area/PubMed/Corpus">000369</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000369</idno><idno type="wicri:Area/PubMed/Curation">000369</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000369</idno><idno type="wicri:Area/PubMed/Checkpoint">000366</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000366</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa.</title><author><name sortKey="Lekana Douki, Jean Bernard" sort="Lekana Douki, Jean Bernard" uniqKey="Lekana Douki J" first="Jean Bernard" last="Lekana-Douki">Jean Bernard Lekana-Douki</name><affiliation wicri:level="1"><nlm:affiliation>Unité de Parasitologie Médicale (UPARAM), Centre International de Recherches Médicales de Franceville (CIRMF) B,P, 769 Franceville, Gabon. lekana_jb@yahoo.fr.</nlm:affiliation><country xml:lang="fr">Gabon</country><wicri:regionArea>Unité de Parasitologie Médicale (UPARAM), Centre International de Recherches Médicales de Franceville (CIRMF) B,P, 769 Franceville</wicri:regionArea><wicri:noRegion>769 Franceville</wicri:noRegion></affiliation></author><author><name sortKey="Oyegue Liabagui, Sandrine Lydie" sort="Oyegue Liabagui, Sandrine Lydie" uniqKey="Oyegue Liabagui S" first="Sandrine Lydie" last="Oyegue Liabagui">Sandrine Lydie Oyegue Liabagui</name></author><author><name sortKey="Bongui, Jean Bernard" sort="Bongui, Jean Bernard" uniqKey="Bongui J" first="Jean Bernard" last="Bongui">Jean Bernard Bongui</name></author><author><name sortKey="Zatra, Rafika" sort="Zatra, Rafika" uniqKey="Zatra R" first="Rafika" last="Zatra">Rafika Zatra</name></author><author><name sortKey="Lebibi, Jacques" sort="Lebibi, Jacques" uniqKey="Lebibi J" first="Jacques" last="Lebibi">Jacques Lebibi</name></author><author><name sortKey="Toure Ndouo, Fousseyni S" sort="Toure Ndouo, Fousseyni S" uniqKey="Toure Ndouo F" first="Fousseyni S" last="Toure-Ndouo">Fousseyni S. Toure-Ndouo</name></author></analytic><series><title level="j">BMC research notes</title><idno type="eISSN">1756-0500</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Malaria remains a major public health problem, especially in tropical and subtropical regions because of the emergence and widespread of antimalarial drug resistance. Traditional medicine represents one potential source of new treatments. Here, we investigated the in vitro antiplasmodial activity of bark extracts from two Fabaceae species (Tetrapleura tertaptera and Copaifera religiosa) traditionally used to treat malaria symptoms in Haut-Ogooué province, Gabon.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">22112366</PMID><DateCompleted><Year>2012</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1756-0500</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><PubDate><Year>2011</Year><Month>Nov</Month><Day>23</Day></PubDate></JournalIssue><Title>BMC research notes</Title><ISOAbbreviation>BMC Res Notes</ISOAbbreviation></Journal><ArticleTitle>In vitro antiplasmodial activity of crude extracts of Tetrapleura tetraptera and Copaifera religiosa.</ArticleTitle><Pagination><MedlinePgn>506</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1756-0500-4-506</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Malaria remains a major public health problem, especially in tropical and subtropical regions because of the emergence and widespread of antimalarial drug resistance. Traditional medicine represents one potential source of new treatments. Here, we investigated the in vitro antiplasmodial activity of bark extracts from two Fabaceae species (Tetrapleura tertaptera and Copaifera religiosa) traditionally used to treat malaria symptoms in Haut-Ogooué province, Gabon.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">The antiplasmodial activity of dichloromethane and methanolic extracts was tested on P. falciparum strains FCB (chloroquine-resistant) and 3D7 (chloroquine-sensitive) and on fresh clinical isolates, using the DELI method. Host cell toxicity was analyzed on MRC-5 human diploid embryonic lung cells using the MTT test.The dichloromethane extracts of the two plants had interesting activity (IC50 between 8.5 ± 4.7 and 13.4 ± 3.6 μg/ml). The methanolic extract of Tetrapleura tetraptera was less active (IC50 around 30 μg/ml) and the methanolic extract of Copaifera religiosa was inactive. The selectivity index (toxicity/antiplasmodial activity) of the dichloromethane extract of Tetrapleura tetraptera was high (around 7), while the dichloromethane extract of Copaifera religiosa had the lowest selectivity (0.6). The mean IC50 values for field isolates were less than 1.5 μg/ml for dichloromethane extracts of both plants, while methanolic extracts of Tetrapleura tetraptera showed interesting activity (IC50 = 13.1 μg/ml). The methanolic extract of Copaifera religiosa was also inactive on field isolates.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Dichloromethane extracts of Tetrapleura tetraptera and Copaifera religiosa, two plants used to treat malaria in Gabon, had interesting antiplasmodial activity in vitro. These data provide a scientific rationale for the traditional use of these plants against malaria symptoms. Bioactivity-guided phytochemical analyses are underway to identify the active compounds.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lekana-Douki</LastName><ForeName>Jean Bernard</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Unité de Parasitologie Médicale (UPARAM), Centre International de Recherches Médicales de Franceville (CIRMF) B,P, 769 Franceville, Gabon. lekana_jb@yahoo.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oyegue Liabagui</LastName><ForeName>Sandrine Lydie</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Bongui</LastName><ForeName>Jean Bernard</ForeName><Initials>JB</Initials></Author><Author ValidYN="Y"><LastName>Zatra</LastName><ForeName>Rafika</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lebibi</LastName><ForeName>Jacques</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Toure-Ndouo</LastName><ForeName>Fousseyni 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IdType="pubmed">17236733</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Gabon</li></country></list><tree><noCountry><name sortKey="Bongui, Jean Bernard" sort="Bongui, Jean Bernard" uniqKey="Bongui J" first="Jean Bernard" last="Bongui">Jean Bernard Bongui</name><name sortKey="Lebibi, Jacques" sort="Lebibi, Jacques" uniqKey="Lebibi J" first="Jacques" last="Lebibi">Jacques Lebibi</name><name sortKey="Oyegue Liabagui, Sandrine Lydie" sort="Oyegue Liabagui, Sandrine Lydie" uniqKey="Oyegue Liabagui S" first="Sandrine Lydie" last="Oyegue Liabagui">Sandrine Lydie Oyegue Liabagui</name><name sortKey="Toure Ndouo, Fousseyni S" sort="Toure Ndouo, Fousseyni S" uniqKey="Toure Ndouo F" first="Fousseyni S" last="Toure-Ndouo">Fousseyni S. Toure-Ndouo</name><name sortKey="Zatra, Rafika" sort="Zatra, Rafika" uniqKey="Zatra R" first="Rafika" last="Zatra">Rafika Zatra</name></noCountry><country name="Gabon"><noRegion><name sortKey="Lekana Douki, Jean Bernard" sort="Lekana Douki, Jean Bernard" uniqKey="Lekana Douki J" first="Jean Bernard" last="Lekana-Douki">Jean Bernard Lekana-Douki</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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