ChloroquineV1, PubMed, Checkpoint, bibRecord, 000216

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.

Identifieur interne : 000216 ( PubMed/Checkpoint ); précédent : 000215; suivant : 000217

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.

Source :

PloS one [ 1932-6203 ] ; 2015.

RBID : pubmed:26382847

Descripteurs français

KwdFr :
- Alvéoles pulmonaires (anatomopathologie), Alvéoles pulmonaires (métabolisme), Animaux, Autophagie (physiologie), Bléomycine, Fibrose pulmonaire (), Fibrose pulmonaire (anatomopathologie), Fibrose pulmonaire (métabolisme), Humains, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (métabolisme), Souris, Souris de lignée C57BL, Souris transgéniques, Sérine-thréonine kinases TOR (génétique), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (physiologie).
MESH :
- anatomopathologie : Alvéoles pulmonaires, Fibrose pulmonaire, Poumon.
- génétique : Sérine-thréonine kinases TOR.
- métabolisme : Alvéoles pulmonaires, Fibrose pulmonaire, Poumon, Sérine-thréonine kinases TOR.
- physiologie : Autophagie, Transduction du signal.
- Animaux, Bléomycine, Fibrose pulmonaire, Humains, Modèles animaux de maladie humaine, Souris, Souris de lignée C57BL, Souris transgéniques.

English descriptors

KwdEn :
- Animals, Autophagy (physiology), Bleomycin, Disease Models, Animal, Humans, Lung (metabolism), Lung (pathology), Mice, Mice, Inbred C57BL, Mice, Transgenic, Pulmonary Alveoli (metabolism), Pulmonary Alveoli (pathology), Pulmonary Fibrosis (chemically induced), Pulmonary Fibrosis (metabolism), Pulmonary Fibrosis (pathology), Signal Transduction (physiology), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , genetics : TOR Serine-Threonine Kinases.
- chemical , metabolism : TOR Serine-Threonine Kinases.
- chemical : Bleomycin.
- chemically induced : Pulmonary Fibrosis.
- metabolism : Lung, Pulmonary Alveoli, Pulmonary Fibrosis.
- pathology : Lung, Pulmonary Alveoli, Pulmonary Fibrosis.
- physiology : Autophagy, Signal Transduction.
- Animals, Disease Models, Animal, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic.

Abstract

The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated in cell and animal models. mTOR overactivation in alveolar epithelial cells (AECs) was achieved in the conditional and inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1(fx/+) (STT). Doxycycline caused Tsc1 knock-down and consequently mTOR activation in AECs for the STT mice. Mice treated with bleomycin exhibited increased mortality and pulmonary fibrosis compared with control mice. In wild-type C57BL/6J mice, pretreatment with rapamycin attenuated the bleomycin-mediated mortality and fibrosis. Rapamycin-mediated mouse survival benefit was inhibited by chloroquine, an autophagy inhibitor. Autophagosomes were decreased in the lungs after bleomycin exposure. Rapamycin induced the production of autophagosomes and diminished p62. We concluded that mTOR overactivation in AECs and compromised autophagy in the lungs are involved in the pathogenesis of pulmonary fibrosis. The suppression of mTOR and enhancement of autophagy may be used for treatment of pulmonary fibrosis.

DOI: 10.1371/journal.pone.0138625
PubMed: 26382847

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000233
to stream PubMed, to step Curation: 000233

Links to Exploration step

pubmed:26382847

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.</title>
<author><name sortKey="Gui, Yao Song" sort="Gui, Yao Song" uniqKey="Gui Y" first="Yao-Song" last="Gui">Yao-Song Gui</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Lianmei" sort="Wang, Lianmei" uniqKey="Wang L" first="Lianmei" last="Wang">Lianmei Wang</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tian, Xinlun" sort="Tian, Xinlun" uniqKey="Tian X" first="Xinlun" last="Tian">Xinlun Tian</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xue" sort="Li, Xue" uniqKey="Li X" first="Xue" last="Li">Xue Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Aiping" sort="Ma, Aiping" uniqKey="Ma A" first="Aiping" last="Ma">Aiping Ma</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Weixun" sort="Zhou, Weixun" uniqKey="Zhou W" first="Weixun" last="Zhou">Weixun Zhou</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zeng, Ni" sort="Zeng, Ni" uniqKey="Zeng N" first="Ni" last="Zeng">Ni Zeng</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Ji" sort="Zhang, Ji" uniqKey="Zhang J" first="Ji" last="Zhang">Ji Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi</wicri:regionArea>
<wicri:noRegion>Wuxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cai, Baiqiang" sort="Cai, Baiqiang" uniqKey="Cai B" first="Baiqiang" last="Cai">Baiqiang Cai</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Hongbing" sort="Zhang, Hongbing" uniqKey="Zhang H" first="Hongbing" last="Zhang">Hongbing Zhang</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Jing Yu" sort="Chen, Jing Yu" uniqKey="Chen J" first="Jing-Yu" last="Chen">Jing-Yu Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi</wicri:regionArea>
<wicri:noRegion>Wuxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Kai Feng" sort="Xu, Kai Feng" uniqKey="Xu K" first="Kai-Feng" last="Xu">Kai-Feng Xu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26382847</idno>
<idno type="pmid">26382847</idno>
<idno type="doi">10.1371/journal.pone.0138625</idno>
<idno type="wicri:Area/PubMed/Corpus">000233</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000233</idno>
<idno type="wicri:Area/PubMed/Curation">000233</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000233</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000216</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000216</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.</title>
<author><name sortKey="Gui, Yao Song" sort="Gui, Yao Song" uniqKey="Gui Y" first="Yao-Song" last="Gui">Yao-Song Gui</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Lianmei" sort="Wang, Lianmei" uniqKey="Wang L" first="Lianmei" last="Wang">Lianmei Wang</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tian, Xinlun" sort="Tian, Xinlun" uniqKey="Tian X" first="Xinlun" last="Tian">Xinlun Tian</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Xue" sort="Li, Xue" uniqKey="Li X" first="Xue" last="Li">Xue Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Aiping" sort="Ma, Aiping" uniqKey="Ma A" first="Aiping" last="Ma">Aiping Ma</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Weixun" sort="Zhou, Weixun" uniqKey="Zhou W" first="Weixun" last="Zhou">Weixun Zhou</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zeng, Ni" sort="Zeng, Ni" uniqKey="Zeng N" first="Ni" last="Zeng">Ni Zeng</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Ji" sort="Zhang, Ji" uniqKey="Zhang J" first="Ji" last="Zhang">Ji Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi</wicri:regionArea>
<wicri:noRegion>Wuxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cai, Baiqiang" sort="Cai, Baiqiang" uniqKey="Cai B" first="Baiqiang" last="Cai">Baiqiang Cai</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Hongbing" sort="Zhang, Hongbing" uniqKey="Zhang H" first="Hongbing" last="Zhang">Hongbing Zhang</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Jing Yu" sort="Chen, Jing Yu" uniqKey="Chen J" first="Jing-Yu" last="Chen">Jing-Yu Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi</wicri:regionArea>
<wicri:noRegion>Wuxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Kai Feng" sort="Xu, Kai Feng" uniqKey="Xu K" first="Kai-Feng" last="Xu">Kai-Feng Xu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Autophagy (physiology)</term>
<term>Bleomycin</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Lung (metabolism)</term>
<term>Lung (pathology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>Pulmonary Alveoli (metabolism)</term>
<term>Pulmonary Alveoli (pathology)</term>
<term>Pulmonary Fibrosis (chemically induced)</term>
<term>Pulmonary Fibrosis (metabolism)</term>
<term>Pulmonary Fibrosis (pathology)</term>
<term>Signal Transduction (physiology)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alvéoles pulmonaires (anatomopathologie)</term>
<term>Alvéoles pulmonaires (métabolisme)</term>
<term>Animaux</term>
<term>Autophagie (physiologie)</term>
<term>Bléomycine</term>
<term>Fibrose pulmonaire ()</term>
<term>Fibrose pulmonaire (anatomopathologie)</term>
<term>Fibrose pulmonaire (métabolisme)</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Bleomycin</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term>
<term>Fibrose pulmonaire</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Pulmonary Fibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term>
<term>Pulmonary Alveoli</term>
<term>Pulmonary Fibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Alvéoles pulmonaires</term>
<term>Fibrose pulmonaire</term>
<term>Poumon</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Pulmonary Alveoli</term>
<term>Pulmonary Fibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Bléomycine</term>
<term>Fibrose pulmonaire</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated in cell and animal models. mTOR overactivation in alveolar epithelial cells (AECs) was achieved in the conditional and inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1(fx/+) (STT). Doxycycline caused Tsc1 knock-down and consequently mTOR activation in AECs for the STT mice. Mice treated with bleomycin exhibited increased mortality and pulmonary fibrosis compared with control mice. In wild-type C57BL/6J mice, pretreatment with rapamycin attenuated the bleomycin-mediated mortality and fibrosis. Rapamycin-mediated mouse survival benefit was inhibited by chloroquine, an autophagy inhibitor. Autophagosomes were decreased in the lungs after bleomycin exposure. Rapamycin induced the production of autophagosomes and diminished p62. We concluded that mTOR overactivation in AECs and compromised autophagy in the lungs are involved in the pathogenesis of pulmonary fibrosis. The suppression of mTOR and enhancement of autophagy may be used for treatment of pulmonary fibrosis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26382847</PMID>
<DateCompleted><Year>2016</Year>
<Month>05</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>9</Issue>
<PubDate><Year>2015</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.</ArticleTitle>
<Pagination><MedlinePgn>e0138625</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0138625</ELocationID>
<Abstract><AbstractText>The mammalian target of rapamycin (mTOR) signaling pathway in pulmonary fibrosis was investigated in cell and animal models. mTOR overactivation in alveolar epithelial cells (AECs) was achieved in the conditional and inducible Tsc1 knock-down mice SPC-rtTA/TetO-Cre/Tsc1(fx/+) (STT). Doxycycline caused Tsc1 knock-down and consequently mTOR activation in AECs for the STT mice. Mice treated with bleomycin exhibited increased mortality and pulmonary fibrosis compared with control mice. In wild-type C57BL/6J mice, pretreatment with rapamycin attenuated the bleomycin-mediated mortality and fibrosis. Rapamycin-mediated mouse survival benefit was inhibited by chloroquine, an autophagy inhibitor. Autophagosomes were decreased in the lungs after bleomycin exposure. Rapamycin induced the production of autophagosomes and diminished p62. We concluded that mTOR overactivation in AECs and compromised autophagy in the lungs are involved in the pathogenesis of pulmonary fibrosis. The suppression of mTOR and enhancement of autophagy may be used for treatment of pulmonary fibrosis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gui</LastName>
<ForeName>Yao-Song</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Lianmei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Xinlun</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xue</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Aiping</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Weixun</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zeng</LastName>
<ForeName>Ni</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Ji</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cai</LastName>
<ForeName>Baiqiang</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Hongbing</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Jing-Yu</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Department of Thoracic Surgery, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Kai-Feng</ForeName>
<Initials>KF</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>09</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>11056-06-7</RegistryNumber>
<NameOfSubstance UI="D001761">Bleomycin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001761" MajorTopicYN="N">Bleomycin</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011650" MajorTopicYN="N">Pulmonary Alveoli</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011658" MajorTopicYN="N">Pulmonary Fibrosis</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>05</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>08</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>5</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26382847</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0138625</ArticleId>
<ArticleId IdType="pii">PONE-D-15-19052</ArticleId>
<ArticleId IdType="pmc">PMC4575195</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L56-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23087019</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2013 Feb 1;187(3):262-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23239155</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hypertens. 2006 Aug;24(8):1663-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16877971</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Clin Exp Pathol. 2011 Jun 20;4(5):476-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21738819</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lymphat Res Biol. 2010 Mar;8(1):43-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20235886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Mol Life Sci. 2012 Apr;69(8):1289-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22068611</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10673212</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2010 Aug;62(8):2476-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20506342</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2011 Dec 1;184(11):1237-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21836133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2004 Aug 15;18(16):1926-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15314020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Signal. 2012 Feb 21;5(212):ra16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22355189</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2014 May 29;370(22):2083-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24836312</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Kidney Int. 2010 Dec;78(11):1075-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20861822</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2007 Dec 15;6(24):3011-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18073529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Paediatr Neurol. 2012 Nov;16(6):582-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22695035</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging Cell. 2013 Jun;12(3):370-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23425014</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2005 May;166(5):1321-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15855634</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Thorac Cardiovasc Surg. 2013 Apr;61(3):223-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22684415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hepatol. 2011 Aug;55(2):388-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21168455</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuron. 2012 Aug 9;75(3):425-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22884327</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biotechnol Bioeng. 2012 Dec;109(12):3093-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22627923</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2014 May 29;370(22):2071-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24836310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncol Lett. 2013 Jan;5(1):167-172</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23255914</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Physiol. 2013 Jul;228(7):1516-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23444126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Nephrol. 2011;34(2):115-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21720156</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Klin (Munich). 2005 Mar 15;100(3):161-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15966446</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5037-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10220414</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Am Thorac Soc. 2006 Jun;3(4):364-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16738202</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):E1475-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22123957</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24160862</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2013 May;9(5):799-800</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23439279</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21471066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Pathol. 1988 Apr;41(4):467-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3366935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J Suppl. 2003 Sep;44:7s-9s</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14582892</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respirology. 2011 Jul;16(5):776-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21362103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2012 Nov;142(5):1289-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23131937</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(9):e44946</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22984591</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(7):e41394</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22815997</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(3):e33626</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22470459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2008 Mar;172(3):571-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18258849</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2002 Jun;19(6):1124-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12108867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Invest Med. 2011;34(6):E341</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22129924</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 2002 Mar 1;11(5):525-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11875047</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2004 Jul 14;24(28):6352-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15254091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2000 Dec 1;290(5497):1717-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11099404</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Gui, Yao Song" sort="Gui, Yao Song" uniqKey="Gui Y" first="Yao-Song" last="Gui">Yao-Song Gui</name>
</noRegion>
<name sortKey="Cai, Baiqiang" sort="Cai, Baiqiang" uniqKey="Cai B" first="Baiqiang" last="Cai">Baiqiang Cai</name>
<name sortKey="Chen, Jing Yu" sort="Chen, Jing Yu" uniqKey="Chen J" first="Jing-Yu" last="Chen">Jing-Yu Chen</name>
<name sortKey="Li, Xue" sort="Li, Xue" uniqKey="Li X" first="Xue" last="Li">Xue Li</name>
<name sortKey="Ma, Aiping" sort="Ma, Aiping" uniqKey="Ma A" first="Aiping" last="Ma">Aiping Ma</name>
<name sortKey="Tian, Xinlun" sort="Tian, Xinlun" uniqKey="Tian X" first="Xinlun" last="Tian">Xinlun Tian</name>
<name sortKey="Wang, Lianmei" sort="Wang, Lianmei" uniqKey="Wang L" first="Lianmei" last="Wang">Lianmei Wang</name>
<name sortKey="Xu, Kai Feng" sort="Xu, Kai Feng" uniqKey="Xu K" first="Kai-Feng" last="Xu">Kai-Feng Xu</name>
<name sortKey="Zeng, Ni" sort="Zeng, Ni" uniqKey="Zeng N" first="Ni" last="Zeng">Ni Zeng</name>
<name sortKey="Zhang, Hongbing" sort="Zhang, Hongbing" uniqKey="Zhang H" first="Hongbing" last="Zhang">Hongbing Zhang</name>
<name sortKey="Zhang, Ji" sort="Zhang, Ji" uniqKey="Zhang J" first="Ji" last="Zhang">Ji Zhang</name>
<name sortKey="Zhou, Weixun" sort="Zhou, Weixun" uniqKey="Zhou W" first="Weixun" last="Zhou">Weixun Zhou</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000216 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000216 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:26382847
   |texte=   mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:26382847" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki