ChloroquineV1, PubMed, Checkpoint, bibRecord, 000210

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.

Identifieur interne : 000210 ( PubMed/Checkpoint ); précédent : 000209; suivant : 000211

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.

Source :

Oncotarget [ 1949-2553 ] ; 2016.

RBID : pubmed:27572309

Descripteurs français

KwdFr :
- Aminopyridines (pharmacologie), Animaux, Antienzymes (pharmacologie), Antinéoplasiques (pharmacologie), Autophagie (), Carcinome pulmonaire non à petites cellules (anatomopathologie), Chloroquine (pharmacologie), Humains, Inhibiteurs de protéines kinases (pharmacologie), Lignée cellulaire tumorale, Morpholines (pharmacologie), Protéines proto-oncogènes c-akt (antagonistes et inhibiteurs), Souris, Système de signalisation des MAP kinases (), Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs du poumon (anatomopathologie).
MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- antagonistes et inhibiteurs : Protéines proto-oncogènes c-akt.
- pharmacologie : Aminopyridines, Antienzymes, Antinéoplasiques, Chloroquine, Inhibiteurs de protéines kinases, Morpholines.
- Animaux, Autophagie, Humains, Lignée cellulaire tumorale, Souris, Système de signalisation des MAP kinases, Tests d'activité antitumorale sur modèle de xénogreffe.

English descriptors

KwdEn :
- Aminopyridines (pharmacology), Animals, Antineoplastic Agents (pharmacology), Autophagy (drug effects), Carcinoma, Non-Small-Cell Lung (pathology), Cell Line, Tumor, Chloroquine (pharmacology), Enzyme Inhibitors (pharmacology), Humans, Lung Neoplasms (pathology), MAP Kinase Signaling System (drug effects), Mice, Morpholines (pharmacology), Phosphoinositide-3 Kinase Inhibitors, Protein Kinase Inhibitors (pharmacology), Proto-Oncogene Proteins c-akt (antagonists & inhibitors), Xenograft Model Antitumor Assays.
MESH :
- chemical , antagonists & inhibitors : Proto-Oncogene Proteins c-akt.
- chemical , pharmacology : Aminopyridines, Antineoplastic Agents, Chloroquine, Enzyme Inhibitors, Morpholines, Protein Kinase Inhibitors.
- drug effects : Autophagy, MAP Kinase Signaling System.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Animals, Cell Line, Tumor, Humans, Mice, Phosphoinositide-3 Kinase Inhibitors, Xenograft Model Antitumor Assays.

Abstract

NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM120 potently induced elevation of autophagosome-bound type II LC3 (LC3-II) protein, predominantly in cell lines insensitive to BKM120, thereby inducing autophagy. The presence of lysosomal protease inhibitor chloroquine further enhanced the levels of LC3-II. BKM120 combined with chloroquine, enhanced growth-inhibitory effects including induction of apoptosis, suggesting that autophagy is a protective mechanism counteracting BKM120's growth-inhibitory activity. Interestingly, BKM120 increased p-ERK1/2 levels. When blocking the activation of this signaling with MEK inhibitors or with knockdown of ERK1/2, the ability of BKM120 to increase LC3-II was attenuated and the growth-inhibitory effects including induction of apoptosis were accordingly enhanced, suggesting that the MEK/ERK activation contributes to BKM120-induced authophagy. In mouse xenograft model, we also found that the combination of BKM120 and PD0325901 synergistically suppressed cell growth in human lung cancer cells. Thus, the current study not only reveals mechanisms accounting for BKM120-induced autophagy, but also suggests an alternative method to enhance BKM120's therapeutic efficacy against non-small cell lung cancer(NSCLC) by blocking autophagy with either a lysosomal protease inhibitor or MEK inhibitor.

DOI: 10.18632/oncotarget.11645
PubMed: 27572309

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000195
to stream PubMed, to step Curation: 000195

Links to Exploration step

pubmed:27572309

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.</title>
<author><name sortKey="Ren, Hui" sort="Ren, Hui" uniqKey="Ren H" first="Hui" last="Ren">Hui Ren</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thakur, Asmitananda" sort="Thakur, Asmitananda" uniqKey="Thakur A" first="Asmitananda" last="Thakur">Asmitananda Thakur</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Ting" sort="Wang, Ting" uniqKey="Wang T" first="Ting" last="Wang">Ting Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liang, Yiqian" sort="Liang, Yiqian" uniqKey="Liang Y" first="Yiqian" last="Liang">Yiqian Liang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Puyu" sort="Shi, Puyu" uniqKey="Shi P" first="Puyu" last="Shi">Puyu Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feng, Jing" sort="Feng, Jing" uniqKey="Feng J" first="Jing" last="Feng">Jing Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Tianjun" sort="Chen, Tianjun" uniqKey="Chen T" first="Tianjun" last="Chen">Tianjun Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Tian" sort="Yang, Tian" uniqKey="Yang T" first="Tian" last="Yang">Tian Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shang, Dong" sort="Shang, Dong" uniqKey="Shang D" first="Dong" last="Shang">Dong Shang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Johnson J" sort="Liu, Johnson J" uniqKey="Liu J" first="Johnson J" last="Liu">Johnson J. Liu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27572309</idno>
<idno type="pmid">27572309</idno>
<idno type="doi">10.18632/oncotarget.11645</idno>
<idno type="wicri:Area/PubMed/Corpus">000195</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000195</idno>
<idno type="wicri:Area/PubMed/Curation">000195</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000195</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000210</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000210</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.</title>
<author><name sortKey="Ren, Hui" sort="Ren, Hui" uniqKey="Ren H" first="Hui" last="Ren">Hui Ren</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thakur, Asmitananda" sort="Thakur, Asmitananda" uniqKey="Thakur A" first="Asmitananda" last="Thakur">Asmitananda Thakur</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Ting" sort="Wang, Ting" uniqKey="Wang T" first="Ting" last="Wang">Ting Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liang, Yiqian" sort="Liang, Yiqian" uniqKey="Liang Y" first="Yiqian" last="Liang">Yiqian Liang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Puyu" sort="Shi, Puyu" uniqKey="Shi P" first="Puyu" last="Shi">Puyu Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feng, Jing" sort="Feng, Jing" uniqKey="Feng J" first="Jing" last="Feng">Jing Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Tianjun" sort="Chen, Tianjun" uniqKey="Chen T" first="Tianjun" last="Chen">Tianjun Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Tian" sort="Yang, Tian" uniqKey="Yang T" first="Tian" last="Yang">Tian Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shang, Dong" sort="Shang, Dong" uniqKey="Shang D" first="Dong" last="Shang">Dong Shang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Johnson J" sort="Liu, Johnson J" uniqKey="Liu J" first="Johnson J" last="Liu">Johnson J. Liu</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi</wicri:regionArea>
<wicri:noRegion>Shaanxi</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Oncotarget</title>
<idno type="eISSN">1949-2553</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopyridines (pharmacology)</term>
<term>Animals</term>
<term>Antineoplastic Agents (pharmacology)</term>
<term>Autophagy (drug effects)</term>
<term>Carcinoma, Non-Small-Cell Lung (pathology)</term>
<term>Cell Line, Tumor</term>
<term>Chloroquine (pharmacology)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Humans</term>
<term>Lung Neoplasms (pathology)</term>
<term>MAP Kinase Signaling System (drug effects)</term>
<term>Mice</term>
<term>Morpholines (pharmacology)</term>
<term>Phosphoinositide-3 Kinase Inhibitors</term>
<term>Protein Kinase Inhibitors (pharmacology)</term>
<term>Proto-Oncogene Proteins c-akt (antagonists & inhibitors)</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aminopyridines (pharmacologie)</term>
<term>Animaux</term>
<term>Antienzymes (pharmacologie)</term>
<term>Antinéoplasiques (pharmacologie)</term>
<term>Autophagie ()</term>
<term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Humains</term>
<term>Inhibiteurs de protéines kinases (pharmacologie)</term>
<term>Lignée cellulaire tumorale</term>
<term>Morpholines (pharmacologie)</term>
<term>Protéines proto-oncogènes c-akt (antagonistes et inhibiteurs)</term>
<term>Souris</term>
<term>Système de signalisation des MAP kinases ()</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Proto-Oncogene Proteins c-akt</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminopyridines</term>
<term>Antineoplastic Agents</term>
<term>Chloroquine</term>
<term>Enzyme Inhibitors</term>
<term>Morpholines</term>
<term>Protein Kinase Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines proto-oncogènes c-akt</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term>
<term>MAP Kinase Signaling System</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term>
<term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminopyridines</term>
<term>Antienzymes</term>
<term>Antinéoplasiques</term>
<term>Chloroquine</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Morpholines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Mice</term>
<term>Phosphoinositide-3 Kinase Inhibitors</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Autophagie</term>
<term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Souris</term>
<term>Système de signalisation des MAP kinases</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM120 potently induced elevation of autophagosome-bound type II LC3 (LC3-II) protein, predominantly in cell lines insensitive to BKM120, thereby inducing autophagy. The presence of lysosomal protease inhibitor chloroquine further enhanced the levels of LC3-II. BKM120 combined with chloroquine, enhanced growth-inhibitory effects including induction of apoptosis, suggesting that autophagy is a protective mechanism counteracting BKM120's growth-inhibitory activity. Interestingly, BKM120 increased p-ERK1/2 levels. When blocking the activation of this signaling with MEK inhibitors or with knockdown of ERK1/2, the ability of BKM120 to increase LC3-II was attenuated and the growth-inhibitory effects including induction of apoptosis were accordingly enhanced, suggesting that the MEK/ERK activation contributes to BKM120-induced authophagy. In mouse xenograft model, we also found that the combination of BKM120 and PD0325901 synergistically suppressed cell growth in human lung cancer cells. Thus, the current study not only reveals mechanisms accounting for BKM120-induced autophagy, but also suggests an alternative method to enhance BKM120's therapeutic efficacy against non-small cell lung cancer(NSCLC) by blocking autophagy with either a lysosomal protease inhibitor or MEK inhibitor.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27572309</PMID>
<DateCompleted><Year>2018</Year>
<Month>02</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>41</Issue>
<PubDate><Year>2016</Year>
<Month>Oct</Month>
<Day>11</Day>
</PubDate>
</JournalIssue>
<Title>Oncotarget</Title>
<ISOAbbreviation>Oncotarget</ISOAbbreviation>
</Journal>
<ArticleTitle>Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.</ArticleTitle>
<Pagination><MedlinePgn>67277-67287</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.11645</ELocationID>
<Abstract><AbstractText>NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM120 potently induced elevation of autophagosome-bound type II LC3 (LC3-II) protein, predominantly in cell lines insensitive to BKM120, thereby inducing autophagy. The presence of lysosomal protease inhibitor chloroquine further enhanced the levels of LC3-II. BKM120 combined with chloroquine, enhanced growth-inhibitory effects including induction of apoptosis, suggesting that autophagy is a protective mechanism counteracting BKM120's growth-inhibitory activity. Interestingly, BKM120 increased p-ERK1/2 levels. When blocking the activation of this signaling with MEK inhibitors or with knockdown of ERK1/2, the ability of BKM120 to increase LC3-II was attenuated and the growth-inhibitory effects including induction of apoptosis were accordingly enhanced, suggesting that the MEK/ERK activation contributes to BKM120-induced authophagy. In mouse xenograft model, we also found that the combination of BKM120 and PD0325901 synergistically suppressed cell growth in human lung cancer cells. Thus, the current study not only reveals mechanisms accounting for BKM120-induced autophagy, but also suggests an alternative method to enhance BKM120's therapeutic efficacy against non-small cell lung cancer(NSCLC) by blocking autophagy with either a lysosomal protease inhibitor or MEK inhibitor.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Hui</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Hua</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Xi'an Central Hospital, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thakur</LastName>
<ForeName>Asmitananda</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Life Guard Hospital, Biratnagar, Nepal.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Shuo</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Ting</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Yiqian</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Puyu</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Tianjun</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Tian</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shang</LastName>
<ForeName>Dong</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Johnson J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Mingwei</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Oncotarget</MedlineTA>
<NlmUniqueID>101532965</NlmUniqueID>
<ISSNLinking>1949-2553</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000631">Aminopyridines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009025">Morpholines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C571178">NVP-BKM120</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000081082">Phosphoinositide-3 Kinase Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047428">Protein Kinase Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>886U3H6UFF</RegistryNumber>
<NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000631" MajorTopicYN="N">Aminopyridines</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002289" MajorTopicYN="N">Carcinoma, Non-Small-Cell Lung</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020935" MajorTopicYN="N">MAP Kinase Signaling System</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009025" MajorTopicYN="N">Morpholines</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000081082" MajorTopicYN="N">Phosphoinositide-3 Kinase Inhibitors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047428" MajorTopicYN="N">Protein Kinase Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023041" MajorTopicYN="N">Xenograft Model Antitumor Assays</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BKM120</Keyword>
<Keyword MajorTopicYN="N">ERK</Keyword>
<Keyword MajorTopicYN="N">apoptosis</Keyword>
<Keyword MajorTopicYN="N">autophagy</Keyword>
<Keyword MajorTopicYN="N">lung cancer</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>09</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>08</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>8</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>2</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>8</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27572309</ArticleId>
<ArticleId IdType="pii">11645</ArticleId>
<ArticleId IdType="doi">10.18632/oncotarget.11645</ArticleId>
<ArticleId IdType="pmc">PMC5341874</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Virchows Arch. 2014 Mar;464(3):347-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24420742</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2015 Apr;14 (4):1014-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25673820</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2007 Nov 15;21(22):2861-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18006683</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2015 Aug 1;364(1):70-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25937299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer. 2013 Nov 22;12 :146</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24261825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2014 Mar 28;344(2):239-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24280585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2015 Jun 30;6(18):15814-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26158412</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Cancer Res. 2015 Sep 1;21(17):3946-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25977343</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biochem Sci. 2011 Jun;36(6):320-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21531565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Carcinogenesis. 2014 Sep;35(9):1951-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24562574</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2012 Jul 1;72(13):3228-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22552284</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Asian Pac J Cancer Prev. 2015;16(11):4759-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26107237</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Discov. 2012 Nov;2(11):1036-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22915752</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2014 Feb 28;343(2):179-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24125861</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Med (Berl). 2012 Jun;90(6):695-706</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22207485</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Oncol. 2012 Jan 20;30(3):282-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22162589</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Cancer Res. 2012 Jan 1;18(1):184-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22065080</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Natl Compr Canc Netw. 2010 Jul;8(7):822-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20679541</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2014 Oct 30;5(20):10034-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25296981</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2012 Dec 28;325(2):139-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22781393</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2010 Feb;6(2):228-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20087064</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2010 Nov 1;70(21):8736-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20959481</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Biol Ther. 2011 Sep 15;12(6):549-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21738008</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2015 Oct;14 (10 ):2175-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26206338</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Drug Discov. 2007 Apr;6(4):304-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17396135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2012 Feb;11(2):317-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22188813</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25559415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer. 2014 Jul 05;13:165</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24996221</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Clin Oncol. 2011 May 17;8(9):528-39</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21587219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2013;4:2799</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24240988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2008 Jan 11;132(1):27-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18191218</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2014 Dec 1;355(1):34-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25236911</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Dis. 2014 Oct 02;5:e1437</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25275598</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>République populaire de Chine</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Sydney</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Ren, Hui" sort="Ren, Hui" uniqKey="Ren H" first="Hui" last="Ren">Hui Ren</name>
</noRegion>
<name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name>
<name sortKey="Chen, Tianjun" sort="Chen, Tianjun" uniqKey="Chen T" first="Tianjun" last="Chen">Tianjun Chen</name>
<name sortKey="Feng, Jing" sort="Feng, Jing" uniqKey="Feng J" first="Jing" last="Feng">Jing Feng</name>
<name sortKey="Gao, Lei" sort="Gao, Lei" uniqKey="Gao L" first="Lei" last="Gao">Lei Gao</name>
<name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name>
<name sortKey="Liang, Yiqian" sort="Liang, Yiqian" uniqKey="Liang Y" first="Yiqian" last="Liang">Yiqian Liang</name>
<name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name>
<name sortKey="Shang, Dong" sort="Shang, Dong" uniqKey="Shang D" first="Dong" last="Shang">Dong Shang</name>
<name sortKey="Shi, Puyu" sort="Shi, Puyu" uniqKey="Shi P" first="Puyu" last="Shi">Puyu Shi</name>
<name sortKey="Thakur, Asmitananda" sort="Thakur, Asmitananda" uniqKey="Thakur A" first="Asmitananda" last="Thakur">Asmitananda Thakur</name>
<name sortKey="Wang, Ting" sort="Wang, Ting" uniqKey="Wang T" first="Ting" last="Wang">Ting Wang</name>
<name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name>
<name sortKey="Yang, Tian" sort="Yang, Tian" uniqKey="Yang T" first="Tian" last="Yang">Tian Yang</name>
<name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Liu, Johnson J" sort="Liu, Johnson J" uniqKey="Liu J" first="Johnson J" last="Liu">Johnson J. Liu</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000210 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000210 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:27572309
   |texte=   Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:27572309" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki