ChloroquineV1, PubMed, Checkpoint, bibRecord, 000045

Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.

Identifieur interne : 000045 ( PubMed/Checkpoint ); précédent : 000044; suivant : 000046

Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.

Auteurs : Zilong Yan [Japon] ; Kenoki Ohuchida [Japon] ; Shuang Fei [Japon] ; Biao Zheng [Japon] ; Weiyu Guan [Japon] ; Haimin Feng [Japon] ; Shin Kibe [Japon] ; Yohei Ando [Japon] ; Kazuhiro Koikawa [Japon] ; Toshiya Abe [Japon] ; Chika Iwamoto [Japon] ; Koji Shindo [Japon] ; Taiki Moriyama [Japon] ; Kohei Nakata [Japon] ; Yoshihiro Miyasaka [Japon] ; Takao Ohtsuka [Japon] ; Kazuhiro Mizumoto [Japon] ; Makoto Hashizume [Japon] ; Masafumi Nakamura [Japon]

Source :

Journal of experimental & clinical cancer research : CR [ 1756-9966 ] ; 2019.

RBID : pubmed:31133044

Descripteurs français

English descriptors

KwdEn :
- Animals, Autophagy, Carcinoma, Pancreatic Ductal (drug therapy), Carcinoma, Pancreatic Ductal (metabolism), Cell Communication (drug effects), Cell Line, Tumor, Cell Movement (drug effects), Cell Proliferation (drug effects), Chloroquine (administration & dosage), Chloroquine (pharmacology), Drug Synergism, Epithelial-Mesenchymal Transition (drug effects), Humans, Indazoles (administration & dosage), Indazoles (pharmacology), Mice, Mitogen-Activated Protein Kinase 1 (metabolism), Mitogen-Activated Protein Kinase 3 (metabolism), Neoplasm Metastasis, Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (metabolism), Pancreatic Stellate Cells (metabolism), Pancreatic Stellate Cells (pathology), Phosphorylation (drug effects), Piperazines (administration & dosage), Piperazines (pharmacology), Protein Kinase Inhibitors (administration & dosage), Protein Kinase Inhibitors (pharmacology), Stromal Cells (metabolism), Stromal Cells (pathology), Xenograft Model Antitumor Assays.
MESH :
- chemical , administration & dosage : Chloroquine, Indazoles, Piperazines, Protein Kinase Inhibitors.
- drug effects : Cell Communication, Cell Movement, Cell Proliferation, Epithelial-Mesenchymal Transition, Phosphorylation.
- drug therapy : Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms.
- metabolism : Carcinoma, Pancreatic Ductal, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Pancreatic Neoplasms, Pancreatic Stellate Cells, Stromal Cells.
- pathology : Pancreatic Stellate Cells, Stromal Cells.
- chemical , pharmacology : Chloroquine, Indazoles, Piperazines, Protein Kinase Inhibitors.
- Animals, Autophagy, Cell Line, Tumor, Drug Synergism, Humans, Mice, Neoplasm Metastasis, Xenograft Model Antitumor Assays.

Abstract

Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS-mutant pancreatic tumors by targeting cancer cell. However, no studies have shown the expression of ERK1/2 on pancreatic stromal and its effect on pancreatic cancer-stromal interaction.

DOI: 10.1186/s13046-019-1226-8
PubMed: 31133044

Affiliations:

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Le document en format XML

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<author><name sortKey="Kibe, Shin" sort="Kibe, Shin" uniqKey="Kibe S" first="Shin" last="Kibe">Shin Kibe</name>
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<country xml:lang="fr">Japon</country>
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<country xml:lang="fr">Japon</country>
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<country xml:lang="fr">Japon</country>
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<country xml:lang="fr">Japon</country>
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<country xml:lang="fr">Japon</country>
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<orgName type="university">Université de Kyūshū</orgName>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
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<author><name sortKey="Miyasaka, Yoshihiro" sort="Miyasaka, Yoshihiro" uniqKey="Miyasaka Y" first="Yoshihiro" last="Miyasaka">Yoshihiro Miyasaka</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
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<author><name sortKey="Ohtsuka, Takao" sort="Ohtsuka, Takao" uniqKey="Ohtsuka T" first="Takao" last="Ohtsuka">Takao Ohtsuka</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582</wicri:regionArea>
<orgName type="university">Université de Kyūshū</orgName>
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<author><name sortKey="Mizumoto, Kazuhiro" sort="Mizumoto, Kazuhiro" uniqKey="Mizumoto K" first="Kazuhiro" last="Mizumoto">Kazuhiro Mizumoto</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Cancer Center of Kyushu University Hospital, Fukuoka</wicri:regionArea>
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<author><name sortKey="Hashizume, Makoto" sort="Hashizume, Makoto" uniqKey="Hashizume M" first="Makoto" last="Hashizume">Makoto Hashizume</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Advanced Medical Initiatives, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
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<author><name sortKey="Nakamura, Masafumi" sort="Nakamura, Masafumi" uniqKey="Nakamura M" first="Masafumi" last="Nakamura">Masafumi Nakamura</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan. mnaka@surg1.med.kyushu-u.ac.jp.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
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<series><title level="j">Journal of experimental & clinical cancer research : CR</title>
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<front><div type="abstract" xml:lang="en">Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS-mutant pancreatic tumors by targeting cancer cell. However, no studies have shown the expression of ERK1/2 on pancreatic stromal and its effect on pancreatic cancer-stromal interaction.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31133044</PMID>
<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1756-9966</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>38</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>May</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Journal of experimental & clinical cancer research : CR</Title>
<ISOAbbreviation>J. Exp. Clin. Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.</ArticleTitle>
<Pagination><MedlinePgn>221</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13046-019-1226-8</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS-mutant pancreatic tumors by targeting cancer cell. However, no studies have shown the expression of ERK1/2 on pancreatic stromal and its effect on pancreatic cancer-stromal interaction.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Immunohistochemistry and western blotting were performed to detect the expression of p-ERK1/2 in pancreatic tissues and cells. Cell viability assay was used to study IC50 of ERK inhibitor on pancreatic cancer cells (PCCs) and primary cancer-associated pancreatic stellate cells (PSCs). Transwell migration, invasion, cell viability assay, senescence β-galactosidase staining were performed to determine the effect of ERK inhibitor on PCCs and PSCs in vitro and in vivo. The expression of key factors involved in autophagy and epithelial-to-mesenchymal transition (EMT) process were evaluated by western blotting. The expression of key factors related to cell invasiveness and malignancy were confirmed by qRT-PCR. Co-transplantation of PCC Organoid and PSC using a splenic xenograft mouse model was used to evaluated combined treatment of ERK inhibitor and autophagy inhibitor.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Immunohistochemical staining in pancreatic tumor samples and transgenetic mice detected p-ERK1/2 expression in both cancer cells and stromal cells. In pancreatic tissues, p-ERK1/2 was strongly expressed in cancer-associated PSCs compared with cancer cells and normal PSCs. PSCs were also significantly more sensitive to ERK1/2 inhibitor treatment. Inhibition of ERK1/2 suppressed EMT transition in HMPCCs, upregulated cellular senescence markers, activated autophagy in cancer-associated PSCs; and suppressed cancer-stromal interaction, which enhanced invasiveness and viability of cancer cells. We also found that chloroquine, an autophagy inhibitor, suppressed ERK inhibition-induced autophagy and promoted PSC cellular senescence, leading to significantly decreased cell proliferation. The combination of an ERK inhibitor and autophagy inhibitor suppressed liver metastasis in a splenic pancreatic cancer organoid xenograft mouse model.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These data indicate that inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Zilong</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ohuchida</LastName>
<ForeName>Kenoki</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-4792-1168</Identifier>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan. kenoki@surg1.med.kyushu-u.ac.jp.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Advanced Medical Initiatives, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. kenoki@surg1.med.kyushu-u.ac.jp.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fei</LastName>
<ForeName>Shuang</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Biao</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of General Surgery, Shenzhen University General Hospital, Shenzhen, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guan</LastName>
<ForeName>Weiyu</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Haimin</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kibe</LastName>
<ForeName>Shin</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ando</LastName>
<ForeName>Yohei</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koikawa</LastName>
<ForeName>Kazuhiro</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abe</LastName>
<ForeName>Toshiya</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Iwamoto</LastName>
<ForeName>Chika</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Advanced Medical Initiatives, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shindo</LastName>
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<ReferenceList><Reference><Citation>Gut. 1999 Apr;44(4):534-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10075961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2004 May 1;64(9):3215-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15126362</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2005 Apr;128(4):907-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15825074</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2005 May;7(5):469-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15894267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer. 2006 Apr 1;106(7):1624-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16518827</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Surg Oncol. 2006 Jul;13(7):933-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16788754</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Cancer. 2006 Aug;6(8):583-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16862189</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2007 Aug;1773(8):1263-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17126425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2007 Apr;6(4):1186-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17406031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Surg Oncol. 2007 Dec;14(12):3527-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17879119</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer. 2007 Dec 1;110(11):2484-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17941009</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2008 Nov 15;68(22):9302-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19010903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S44-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19896098</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Cancer. 2010 Jan;10(1):51-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20029423</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2010 Sep;139(3):1041-51, 1051.e1-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20685603</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gut. 2011 Jun;60(6):861-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20966025</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):380-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21081113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anticancer Res. 2011 Apr;31(4):1147-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21508358</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(8):e23367</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21858089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2011 Oct 21;286(42):36396-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21880712</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Cancer. 2012 Apr 15;130(8):1715-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22025288</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncologist. 2012;17(6):766-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22584435</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Discov. 2012 May;2(5):401-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22588877</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2012 Jun 15;11(12):2285-302</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22684298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Res Int. 2012;2012:951574</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22924132</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2013 Apr 1;73(7):2345-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23348422</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Signal. 2013 Apr 02;6(269):pl1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23550210</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Discov. 2013 Jul;3(7):742-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23614898</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Biol Ther. 2013 Nov;14(11):1059-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24025354</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2013;4:2799</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24240988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 Jan 15;160(1-2):324-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25557080</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Cancer Res. 2015 Aug 1;21(15):3561-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25695692</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2015 Jun 1;75(11):2349-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25855378</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Carcinog. 2016 Nov;55(11):1560-1572</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26373617</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2015 Nov;21(11):1364-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26501191</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2016 Jan 11;29(1):75-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26725216</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2016 Jan 7;529(7584):37-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26738589</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Oncol. 2016 Apr;48(4):1688-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26892887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cold Spring Harb Perspect Med. 2016 Apr 01;6(4):a026120</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27037419</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Sci. 2016 Oct;107(10):1443-1452</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27487486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Res. 2017 Jan;15(1):3-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27678171</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2017 May;152(6):1492-1506.e24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28126348</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2017 Jul 27;36(30):4336-4348</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28368414</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2017 Jun 27;8:15916</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28653662</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2017 Sep 1;77(17):4602-4612</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28674078</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2017 Dec;23(12):1424-1435</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29131160</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2018 Jul 1;425:65-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29580808</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2018 Apr 5;173(2):515-528.e17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29625057</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Clin Cancer Res. 2018 Jul 9;37(1):140</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29986755</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cancer Res Clin Oncol. 2019 May;145(5):1147-1164</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30770989</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 1998 Aug;115(2):421-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9679048</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gut. 1998 Jul;43(1):128-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9771417</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Serveur d'exploration Chloroquine

Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.

Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.

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