Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation.
Identifieur interne : 000040 ( PubMed/Checkpoint ); précédent : 000039; suivant : 000041Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation.
Auteurs : Myoung Seok Jeong [Corée du Sud] ; Ji Hoon Jung [Corée du Sud] ; Hyemin Lee [Corée du Sud] ; Chang Geun Kim [Corée du Sud] ; Sung-Hoon Kim [Corée du Sud]Source :
- OncoTargets and therapy [ 1178-6930 ] ; 2019.
Abstract
To develop a potent anticancer agent similar to oleanolate, the underlying mechanisms of its derivative, methyloleanolate, in the apoptosis and autophagy of A549 and H1299 cells were elucidated.
DOI: 10.2147/OTT.S211904
PubMed: 31695422
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c-Jun N-terminal Kinase Phosphorylation.</title><author><name sortKey="Jeong, Myoung Seok" sort="Jeong, Myoung Seok" uniqKey="Jeong M" first="Myoung Seok" last="Jeong">Myoung Seok Jeong</name><affiliation wicri:level="1"><nlm:affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jung, Ji Hoon" sort="Jung, Ji Hoon" uniqKey="Jung J" first="Ji Hoon" last="Jung">Ji Hoon Jung</name><affiliation wicri:level="1"><nlm:affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyemin" sort="Lee, Hyemin" uniqKey="Lee H" first="Hyemin" last="Lee">Hyemin Lee</name><affiliation wicri:level="1"><nlm:affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Chang Geun" sort="Kim, Chang Geun" uniqKey="Kim C" first="Chang Geun" last="Kim">Chang Geun Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Sung Hoon" sort="Kim, Sung Hoon" uniqKey="Kim S" first="Sung-Hoon" last="Kim">Sung-Hoon Kim</name><affiliation wicri:level="1"><nlm:affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">OncoTargets and therapy</title><idno type="ISSN">1178-6930</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To develop a potent anticancer agent similar to oleanolate, the underlying mechanisms of its derivative, methyloleanolate, in the apoptosis and autophagy of A549 and H1299 cells were elucidated.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">31695422</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>08</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1178-6930</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>OncoTargets and therapy</Title><ISOAbbreviation>Onco Targets Ther</ISOAbbreviation></Journal><ArticleTitle>Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation.</ArticleTitle><Pagination><MedlinePgn>8621-8635</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2147/OTT.S211904</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">To develop a potent anticancer agent similar to oleanolate, the underlying mechanisms of its derivative, methyloleanolate, in the apoptosis and autophagy of A549 and H1299 cells were elucidated.</AbstractText><AbstractText Label="Purpose" NlmCategory="UNASSIGNED">The aim of the present study was to investigate the effect of methyloleanolate in inducing apoptotic and autophagic cell death in cancer cells.</AbstractText><AbstractText Label="Materials and methods" NlmCategory="UNASSIGNED">Flow cytometric analysis with Annexin V/PI staining, Western blot analysis, and immunofluorescence analysis were conducted in A549 and H1299 cells.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Methyloleanolate increased the fraction of Annexin V/PI apoptotic cells and activated caspase-8, caspase-3, and death receptor 5 (DR5) more than oleanolate in A549 and H1299 cells pretreated with pancaspase inhibitor z-VAD-fmk and DR5 depletion. Also, methyloleanolate induced autophagic features of microtubule-associated protein light chain 3 3BII (LC3BII) conversion and puncta in A549 and H1299 cells, along with autophagosomes and vacuoles. Methyloleanolate blocked autophagy flux for impaired autophagy and chloroquine (CQ)-enhanced microtubule-associated protein LC3BII accumulation and cytotoxicity in A549 and H1299 cells, although 3-methyladenine (3-MA) did not. Interestingly, LC3BII accumulation was detected only in methyloleanolate-treated autophagy-related gene 5 (<i>ATG5</i>)<sup>+/+</sup> mouse embryonic fibroblast (MEF) cells but not in <i>ATG5</i><sup>-/-</sup> MEF cells. Methyloleanolate reduced p-mTOR but activated p-c-Jun N-terminal kinases and reactive oxygen species production in A549 and H1299 cells. Conversely, n-acetyl-l-cysteine and SP600125 blocked apoptotic and autophagic cascades caused by methyloleanolate in A549 and H1299 cells.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Overall, the findings suggest that methyloleanolate induces apoptotic and autophagic cell death in non-small cell lung cancers via reactive oxygen species generation and c-Jun N-terminal kinase phosphorylation.</AbstractText><CopyrightInformation>© 2019 Jeong et al.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Jeong</LastName><ForeName>Myoung Seok</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Jung</LastName><ForeName>Ji Hoon</ForeName><Initials>JH</Initials><Identifier Source="ORCID">0000-0002-5644-5960</Identifier><AffiliationInfo><Affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Hyemin</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0003-3910-5611</Identifier><AffiliationInfo><Affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Chang Geun</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sung-Hoon</ForeName><Initials>SH</Initials><Identifier Source="ORCID">0000-0003-2423-1973</Identifier><AffiliationInfo><Affiliation>College of Korean Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 02447, Republic of Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>Onco Targets Ther</MedlineTA><NlmUniqueID>101514322</NlmUniqueID><ISSNLinking>1178-6930</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">JNK</Keyword><Keyword MajorTopicYN="N">ROS</Keyword><Keyword MajorTopicYN="N">apoptosis</Keyword><Keyword MajorTopicYN="N">autophagy</Keyword><Keyword MajorTopicYN="N">methyloleanolate</Keyword></KeywordList><CoiStatement>The authors report no conflicts of interest in this work.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate 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IdType="pubmed">28029600</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cancer. 2011 Jul 1;117(13):2970-85</Citation><ArticleIdList><ArticleId IdType="pubmed">21225866</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chem Res Toxicol. 2008 Feb;21(2):393-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18078328</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biosci Rep. 2015 Apr 22;35(3):null</Citation><ArticleIdList><ArticleId IdType="pubmed">26182361</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Am J Pathol. 2010 Mar;176(3):1065-71</Citation><ArticleIdList><ArticleId IdType="pubmed">20150434</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Oncotarget. 2015 Nov 24;6(37):40268-82</Citation><ArticleIdList><ArticleId IdType="pubmed">26384345</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lung Cancer. 2015 Jun;88(3):304-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25870155</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Int J Cancer. 2010 Dec 15;127(12):2790-803</Citation><ArticleIdList><ArticleId IdType="pubmed">21351258</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>In Vitro Cell Dev Biol Anim. 2015 Mar;51(3):300-9</Citation><ArticleIdList><ArticleId IdType="pubmed">25381036</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biofactors. 2000;13(1-4):231-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11237187</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Crit Rev Oncol Hematol. 2007 Sep;63(3):241-4</Citation><ArticleIdList><ArticleId IdType="pubmed">17644402</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Curr Opin Cell Biol. 2004 Dec;16(6):663-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15530778</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Oncol Rep. 2014 Aug;32(2):567-72</Citation><ArticleIdList><ArticleId IdType="pubmed">24912497</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cancer Biother Radiopharm. 2010 Feb;25(1):75-80</Citation><ArticleIdList><ArticleId IdType="pubmed">20187799</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nutr Cancer. 2014;66(8):1331-41</Citation><ArticleIdList><ArticleId IdType="pubmed">25356681</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Circ Res. 2008 Aug 15;103(4):343-51</Citation><ArticleIdList><ArticleId IdType="pubmed">18703786</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Transl Res. 2016 Apr;170:1-7</Citation><ArticleIdList><ArticleId IdType="pubmed">26687391</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Thorac Oncol. 2016 Feb;11(2):174-86</Citation><ArticleIdList><ArticleId IdType="pubmed">26845114</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Mol Pharmacol. 2007 Jul;72(1):29-39</Citation><ArticleIdList><ArticleId IdType="pubmed">17395690</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Stem Cells. 2016 Jun;34(6):1651-63</Citation><ArticleIdList><ArticleId IdType="pubmed">26930546</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cancer Treat Rev. 2008 Dec;34(8):737-49</Citation><ArticleIdList><ArticleId IdType="pubmed">18722718</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2001 Jul;2(7):545-50</Citation><ArticleIdList><ArticleId IdType="pubmed">11433369</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Autophagy. 2011 May;7(5):509-24</Citation><ArticleIdList><ArticleId IdType="pubmed">21325880</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Autophagy. 2012 Jan;8(1):6-17</Citation><ArticleIdList><ArticleId IdType="pubmed">22170155</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Trends Biochem Sci. 2010 Oct;35(10):556-64</Citation><ArticleIdList><ArticleId IdType="pubmed">20537543</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Oncogene. 2014 Jun 5;33(23):3004-13</Citation><ArticleIdList><ArticleId IdType="pubmed">23831571</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nature. 1994 May 12;369(6476):156-60</Citation><ArticleIdList><ArticleId IdType="pubmed">8177321</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Biol Int. 2017 Dec;41(12):1367-1378</Citation><ArticleIdList><ArticleId IdType="pubmed">28880428</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Asian Pac J Cancer Prev. 2014;15(11):4519-25</Citation><ArticleIdList><ArticleId IdType="pubmed">24969879</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Redox Biol. 2015;4:184-92</Citation><ArticleIdList><ArticleId IdType="pubmed">25590798</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antioxid Redox Signal. 2014 Jul 1;21(1):86-102</Citation><ArticleIdList><ArticleId IdType="pubmed">24359220</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 2004 Jun 4;304(5676):1497-500</Citation><ArticleIdList><ArticleId IdType="pubmed">15118125</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Oncol Lett. 2016 Dec;12(6):5349-5355</Citation><ArticleIdList><ArticleId IdType="pubmed">28101246</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Anat Embryol (Berl). 1990;181(3):195-213</Citation><ArticleIdList><ArticleId IdType="pubmed">2186664</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Phytochemistry. 2012 May;77:10-5</Citation><ArticleIdList><ArticleId IdType="pubmed">22377690</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Cell Physiol. 2017 Nov;232(11):2977-2984</Citation><ArticleIdList><ArticleId IdType="pubmed">28067409</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Death Differ. 2006 May;13(5):730-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16341124</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Invest. 2015 Jan;125(1):25-32</Citation><ArticleIdList><ArticleId IdType="pubmed">25654547</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cancer Med. 2018 Feb;7(2):471-484</Citation><ArticleIdList><ArticleId IdType="pubmed">29282893</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Death Differ. 2007 Mar;14(3):500-10</Citation><ArticleIdList><ArticleId IdType="pubmed">16990848</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Phytochemistry. 1997 Jul;45(6):1293-4</Citation><ArticleIdList><ArticleId IdType="pubmed">9272969</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pharmacol Rev. 2012 Oct;64(4):972-1003</Citation><ArticleIdList><ArticleId IdType="pubmed">22966038</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>CA Cancer J Clin. 2015 Mar;65(2):87-108</Citation><ArticleIdList><ArticleId IdType="pubmed">25651787</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Death Differ. 2001 Jun;8(6):569-81</Citation><ArticleIdList><ArticleId IdType="pubmed">11536007</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Nutr Biochem. 2013 Apr;24(4):706-12</Citation><ArticleIdList><ArticleId IdType="pubmed">22841540</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2002 Oct;3(10):779-87</Citation><ArticleIdList><ArticleId IdType="pubmed">12360194</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Prod Rep. 2011 Mar;28(3):543-93</Citation><ArticleIdList><ArticleId IdType="pubmed">21290067</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Free Radic Biol Med. 2015 Dec;89:452-65</Citation><ArticleIdList><ArticleId IdType="pubmed">26454086</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Nutr. 2005 Mar;135(3):525-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15735088</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Death Differ. 2009 Jul;16(7):966-75</Citation><ArticleIdList><ArticleId IdType="pubmed">19325568</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de 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