Determination of antibodies in everyday rheumatological practice
Identifieur interne : 000B06 ( Pmc/Curation ); précédent : 000B05; suivant : 000B07Determination of antibodies in everyday rheumatological practice
Auteurs : Katarzyna Napi Rkowska-Baran [Pologne] ; Joanna Zalewska [Pologne] ; Sławomir Jeka [Pologne] ; Iwona Dankiewicz-Fares [Pologne] ; Marcin Zi Tkiewicz [Pologne] ; Ewa Szynkiewicz [Pologne] ; Sylwia Kołtan [Pologne] ; Adam Wawrze Czyk [Pologne] ; Ewa Wi Sik-Szewczyk [Pologne] ; Zbigniew Bartuzi [Pologne]Source :
- Reumatologia [ 0034-6233 ] ; 2019.
Abstract
Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the γ-globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.
Url:
DOI: 10.5114/reum.2019.84814
PubMed: 31130747
PubMed Central: 6532108
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<author><name sortKey="Bartuzi, Zbigniew" sort="Bartuzi, Zbigniew" uniqKey="Bartuzi Z" first="Zbigniew" last="Bartuzi">Zbigniew Bartuzi</name>
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<series><title level="j">Reumatologia</title>
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<front><div type="abstract" xml:lang="en"><p>Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the γ-globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Reumatologia</journal-id>
<journal-id journal-id-type="iso-abbrev">Reumatologia</journal-id>
<journal-id journal-id-type="publisher-id">RU</journal-id>
<journal-title-group><journal-title>Reumatologia</journal-title>
</journal-title-group>
<issn pub-type="ppub">0034-6233</issn>
<issn pub-type="epub">2084-9834</issn>
<publisher><publisher-name>Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31130747</article-id>
<article-id pub-id-type="pmc">6532108</article-id>
<article-id pub-id-type="publisher-id">84814</article-id>
<article-id pub-id-type="doi">10.5114/reum.2019.84814</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Determination of antibodies in everyday rheumatological practice</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Napiórkowska-Baran</surname>
<given-names>Katarzyna</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zalewska</surname>
<given-names>Joanna</given-names>
</name>
<xref ref-type="aff" rid="aff0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jeka</surname>
<given-names>Sławomir</given-names>
</name>
<xref ref-type="aff" rid="aff0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dankiewicz-Fares</surname>
<given-names>Iwona</given-names>
</name>
<xref ref-type="aff" rid="aff0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ziętkiewicz</surname>
<given-names>Marcin</given-names>
</name>
<xref ref-type="aff" rid="aff0003">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szynkiewicz</surname>
<given-names>Ewa</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kołtan</surname>
<given-names>Sylwia</given-names>
</name>
<xref ref-type="aff" rid="aff0004">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wawrzeńczyk</surname>
<given-names>Adam</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Więsik-Szewczyk</surname>
<given-names>Ewa</given-names>
</name>
<xref ref-type="aff" rid="aff0005">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bartuzi</surname>
<given-names>Zbigniew</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
</contrib-group>
<aff id="aff0001"><label>1</label>
Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</aff>
<aff id="aff0002"><label>2</label>
Clinic of Rheumatology and Connective Tissue Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</aff>
<aff id="aff0003"><label>3</label>
Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Poland</aff>
<aff id="aff0004"><label>4</label>
Department of Paediatrics, Haematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland</aff>
<aff id="aff0005"><label>5</label>
Department of Internal Medicine, Pneumonology, Allergology, and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, Warsaw, Poland</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence:</bold>
Katarzyna Napiórkowska-Baran, Department of Allergology, Clinical Immunology and Internal Diseases, <italic>Collegium Medicum</italic>
in Bydgoszcz, Nicolaus Copernicus University in Toruń, 75 Ujejskiego St., 85-168 Bydgoszcz, Poland. e-mail: <email xlink:href="k_napiorko@poczta.fm">k_napiorko@poczta.fm</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>29</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="ppub"><year>2019</year>
</pub-date>
<volume>57</volume>
<issue>2</issue>
<fpage>91</fpage>
<lpage>99</lpage>
<history><date date-type="received"><day>14</day>
<month>2</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>17</day>
<month>4</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2019 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.</license-p>
</license>
</permissions>
<abstract><p>Antibody determination is routinely used in everyday rheumatological practice. Its result repeatedly determines the diagnosis or exclusion of a particular disease. Antibodies are immunoglobulins, i.e. some of the most important proteins in the immune system, and have specific properties that we should know. In addition, there are a number of factors that can affect their concentration, including drugs commonly used in the treatment of rheumatic diseases. There are definite indications, when the total concentrations of individual classes of immunoglobulins should be initially determined and it should be evaluated whether the patient produces them at all or their production is impaired. In some cases, we should evaluate the levels of specific antibodies along with the total protein concentration and the γ-globulin fraction, in which the antibodies are contained. The article presents information on the most common mistakes made when performing these tests.</p>
</abstract>
<kwd-group><kwd>rheumatic diseases</kwd>
<kwd>immunoglobulins</kwd>
<kwd>antibodies</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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