The cat is out of the bag: How parasites know their hosts
Identifieur interne : 000A92 ( Pmc/Curation ); précédent : 000A91; suivant : 000A93The cat is out of the bag: How parasites know their hosts
Auteurs : Elizabeth D. English ; Boris StriepenSource :
- PLoS Biology [ 1544-9173 ] ; 2019.
Abstract
Url:
DOI: 10.1371/journal.pbio.3000446
PubMed: 31487278
PubMed Central: 6748446
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The cat is out of the bag: How parasites know their hosts</title><author><name sortKey="English, Elizabeth D" sort="English, Elizabeth D" uniqKey="English E" first="Elizabeth D." last="English">Elizabeth D. English</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Striepen, Boris" sort="Striepen, Boris" uniqKey="Striepen B" first="Boris" last="Striepen">Boris Striepen</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31487278</idno><idno type="pmc">6748446</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748446</idno><idno type="RBID">PMC:6748446</idno><idno type="doi">10.1371/journal.pbio.3000446</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A92</idno><idno type="wicri:Area/Pmc/Curation">000A92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The cat is out of the bag: How parasites know their hosts</title><author><name sortKey="English, Elizabeth D" sort="English, Elizabeth D" uniqKey="English E" first="Elizabeth D." last="English">Elizabeth D. English</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Striepen, Boris" sort="Striepen, Boris" uniqKey="Striepen B" first="Boris" last="Striepen">Boris Striepen</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS Biology</title><idno type="ISSN">1544-9173</idno><idno type="eISSN">1545-7885</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Toxoplasma gondii</italic> is a remarkably successful protozoan parasite that infects a third of the human population, along with most mammals and birds. However, the sexual portion of the parasite’s life cycle is narrowly limited to cats. How parasites distinguish between hosts has long been a mystery. A new study reveals that <italic>Toxoplasma</italic> identifies cats based on a single fatty acid, linoleic acid. Experimental manipulation of fatty acid metabolism by drug treatment turns a mouse into a cat in the “eye” of the parasite. This new model enables genetic crosses of an important human pathogen without the use of companion animals and opens the door to future discovery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Martorelli Di Genova, B" uniqKey="Martorelli Di Genova B">B Martorelli Di Genova</name></author><author><name sortKey="Wilson, Sk" uniqKey="Wilson S">SK Wilson</name></author><author><name sortKey="Dubey, Jp" uniqKey="Dubey J">JP Dubey</name></author><author><name sortKey="Knoll, Lj" uniqKey="Knoll L">LJ Knoll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blader, Ij" uniqKey="Blader I">IJ Blader</name></author><author><name sortKey="Coleman, Bi" uniqKey="Coleman B">BI Coleman</name></author><author><name sortKey="Chen, Ct" uniqKey="Chen C">CT Chen</name></author><author><name sortKey="Gubbels, Mj" uniqKey="Gubbels M">MJ Gubbels</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Biol</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Biol</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosbiol</journal-id><journal-title-group><journal-title>PLoS Biology</journal-title></journal-title-group><issn pub-type="ppub">1544-9173</issn><issn pub-type="epub">1545-7885</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31487278</article-id><article-id pub-id-type="pmc">6748446</article-id><article-id pub-id-type="doi">10.1371/journal.pbio.3000446</article-id><article-id pub-id-type="publisher-id">PBIOLOGY-D-19-02189</article-id><article-categories><subj-group subj-group-type="heading"><subject>Primer</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Parasitic Diseases</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Developmental Biology</subject><subj-group><subject>Life Cycles</subject><subj-group><subject>Parasitic Life Cycles</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Parasitology</subject><subj-group><subject>Parasitic Life Cycles</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Eukaryota</subject><subj-group><subject>Protozoans</subject><subj-group><subject>Parasitic Protozoans</subject><subj-group><subject>Toxoplasma</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Biochemistry</subject><subj-group><subject>Lipids</subject><subj-group><subject>Fatty Acids</subject><subj-group><subject>Linoleic Acid</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Parasitic Diseases</subject><subj-group><subject>Parasitic Intestinal Diseases</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Eukaryota</subject><subj-group><subject>Animals</subject><subj-group><subject>Vertebrates</subject><subj-group><subject>Amniotes</subject><subj-group><subject>Mammals</subject><subj-group><subject>Cats</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Parasitology</subject><subj-group><subject>Veterinary Parasitology</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Veterinary Science</subject><subj-group><subject>Veterinary Parasitology</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Eukaryota</subject><subj-group><subject>Protozoans</subject><subj-group><subject>Parasitic Protozoans</subject><subj-group><subject>Toxoplasma</subject><subj-group><subject>Toxoplasma Gondii</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>The cat is out of the bag: How parasites know their hosts</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-2246-8697</contrib-id><name><surname>English</surname><given-names>Elizabeth D.</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-7426-432X</contrib-id><name><surname>Striepen</surname><given-names>Boris</given-names></name><xref ref-type="aff" rid="aff001"></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib></contrib-group><aff id="aff001"><addr-line>Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p>The authors have declared that no competing interests exist.</p></fn><corresp id="cor001">* E-mail: <email>striepen@upenn.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>5</day><month>9</month><year>2019</year></pub-date><pub-date pub-type="collection"><month>9</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>9</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>17</volume><issue>9</issue><elocation-id>e3000446</elocation-id><permissions><copyright-statement>© 2019 English, Striepen</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>English, Striepen</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pbio.3000446.pdf"></self-uri><related-article related-article-type="companion" id="d35e229" ext-link-type="doi" xlink:href="10.1371/journal.pbio.3000364"><article-title>Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction</article-title></related-article><abstract><p><italic>Toxoplasma gondii</italic> is a remarkably successful protozoan parasite that infects a third of the human population, along with most mammals and birds. However, the sexual portion of the parasite’s life cycle is narrowly limited to cats. How parasites distinguish between hosts has long been a mystery. A new study reveals that <italic>Toxoplasma</italic> identifies cats based on a single fatty acid, linoleic acid. Experimental manipulation of fatty acid metabolism by drug treatment turns a mouse into a cat in the “eye” of the parasite. This new model enables genetic crosses of an important human pathogen without the use of companion animals and opens the door to future discovery.</p></abstract><abstract abstract-type="toc"><p>The parasite Toxoplasma gondii infects a wide range of mammals and birds but the sexual part of its life cycle only unfolds in cats. This Primer explores the implications of a new study that reveals the molecular cue by which the parasite distinguishes cats from other animals.</p></abstract><funding-group><funding-statement>Work in our laboratory is funded by multiple grants from the National Institutes of Health and Bill and Melinda Gates Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="2"></fig-count><table-count count="0"></table-count><page-count count="6"></page-count></counts><custom-meta-group><custom-meta><meta-name>PLOS Publication Stage</meta-name><meta-value>vor-update-to-uncorrected-proof</meta-value></custom-meta><custom-meta><meta-name>Publication Update</meta-name><meta-value>2019-09-17</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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