Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action
Identifieur interne : 000A57 ( Pmc/Curation ); précédent : 000A56; suivant : 000A58Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action
Auteurs : Alejandro M. S. Mayer ; Aimee J. Guerrero ; Abimael D. Rodríguez ; Orazio Taglialatela-Scafati ; Fumiaki Nakamura ; Nobuhiro FusetaniSource :
- Marine Drugs [ 1660-3397 ] ; 2019.
Abstract
The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the
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DOI: 10.3390/md18010005
PubMed: 31861527
PubMed Central: 7024264
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action</title><author><name sortKey="Mayer, Alejandro M S" sort="Mayer, Alejandro M S" uniqKey="Mayer A" first="Alejandro M. S." last="Mayer">Alejandro M. S. Mayer</name><affiliation><nlm:aff id="af1-marinedrugs-18-00005">Department of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA;<email>aguerrero89@midwestern.edu</email></nlm:aff></affiliation></author><author><name sortKey="Guerrero, Aimee J" sort="Guerrero, Aimee J" uniqKey="Guerrero A" first="Aimee J." last="Guerrero">Aimee J. Guerrero</name><affiliation><nlm:aff id="af1-marinedrugs-18-00005">Department of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA;<email>aguerrero89@midwestern.edu</email></nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Abimael D" sort="Rodriguez, Abimael D" uniqKey="Rodriguez A" first="Abimael D." last="Rodríguez">Abimael D. Rodríguez</name><affiliation><nlm:aff id="af2-marinedrugs-18-00005">Molecular Sciences Research Center, University of Puerto Rico, 1390 Ponce de León Avenue, San Juan, PR 00926, USA;<email>abimael.rodriguez1@upr.edu</email></nlm:aff></affiliation></author><author><name sortKey="Taglialatela Scafati, Orazio" sort="Taglialatela Scafati, Orazio" uniqKey="Taglialatela Scafati O" first="Orazio" last="Taglialatela-Scafati">Orazio Taglialatela-Scafati</name><affiliation><nlm:aff id="af3-marinedrugs-18-00005">Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy;<email>scatagli@unina.it</email></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Fumiaki" sort="Nakamura, Fumiaki" uniqKey="Nakamura F" first="Fumiaki" last="Nakamura">Fumiaki Nakamura</name><affiliation><nlm:aff id="af4-marinedrugs-18-00005">Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;<email>what-will_be.x2@akane.waseda.jp</email></nlm:aff></affiliation></author><author><name sortKey="Fusetani, Nobuhiro" sort="Fusetani, Nobuhiro" uniqKey="Fusetani N" first="Nobuhiro" last="Fusetani">Nobuhiro Fusetani</name><affiliation><nlm:aff id="af5-marinedrugs-18-00005">Fisheries and Oceans Hakodate, Hakodate 041-8611, Japan;<email>anobu@fish.hokudai.ac.jp</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31861527</idno><idno type="pmc">7024264</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024264</idno><idno type="RBID">PMC:7024264</idno><idno type="doi">10.3390/md18010005</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A57</idno><idno type="wicri:Area/Pmc/Curation">000A57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action</title><author><name sortKey="Mayer, Alejandro M S" sort="Mayer, Alejandro M S" uniqKey="Mayer A" first="Alejandro M. S." last="Mayer">Alejandro M. S. Mayer</name><affiliation><nlm:aff id="af1-marinedrugs-18-00005">Department of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA;<email>aguerrero89@midwestern.edu</email></nlm:aff></affiliation></author><author><name sortKey="Guerrero, Aimee J" sort="Guerrero, Aimee J" uniqKey="Guerrero A" first="Aimee J." last="Guerrero">Aimee J. Guerrero</name><affiliation><nlm:aff id="af1-marinedrugs-18-00005">Department of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA;<email>aguerrero89@midwestern.edu</email></nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Abimael D" sort="Rodriguez, Abimael D" uniqKey="Rodriguez A" first="Abimael D." last="Rodríguez">Abimael D. Rodríguez</name><affiliation><nlm:aff id="af2-marinedrugs-18-00005">Molecular Sciences Research Center, University of Puerto Rico, 1390 Ponce de León Avenue, San Juan, PR 00926, USA;<email>abimael.rodriguez1@upr.edu</email></nlm:aff></affiliation></author><author><name sortKey="Taglialatela Scafati, Orazio" sort="Taglialatela Scafati, Orazio" uniqKey="Taglialatela Scafati O" first="Orazio" last="Taglialatela-Scafati">Orazio Taglialatela-Scafati</name><affiliation><nlm:aff id="af3-marinedrugs-18-00005">Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy;<email>scatagli@unina.it</email></nlm:aff></affiliation></author><author><name sortKey="Nakamura, Fumiaki" sort="Nakamura, Fumiaki" uniqKey="Nakamura F" first="Fumiaki" last="Nakamura">Fumiaki Nakamura</name><affiliation><nlm:aff id="af4-marinedrugs-18-00005">Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;<email>what-will_be.x2@akane.waseda.jp</email></nlm:aff></affiliation></author><author><name sortKey="Fusetani, Nobuhiro" sort="Fusetani, Nobuhiro" uniqKey="Fusetani N" first="Nobuhiro" last="Fusetani">Nobuhiro Fusetani</name><affiliation><nlm:aff id="af5-marinedrugs-18-00005">Fisheries and Oceans Hakodate, Hakodate 041-8611, Japan;<email>anobu@fish.hokudai.ac.jp</email></nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the <italic>preclinical</italic> marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the <italic>clinical</italic> marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mayer, A M S" uniqKey="Mayer A">A.M.S. Mayer</name></author><author><name sortKey="Lehmann, V K B" uniqKey="Lehmann V">V.K.B. Lehmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayer, A M" uniqKey="Mayer A">A.M. Mayer</name></author><author><name sortKey="Hamann, M T" uniqKey="Hamann M">M.T. Hamann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayer, A M S" uniqKey="Mayer A">A.M.S. Mayer</name></author><author><name sortKey="Hamann, M T" uniqKey="Hamann M">M.T. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id><journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id><journal-id journal-id-type="publisher-id">marinedrugs</journal-id><journal-title-group><journal-title>Marine Drugs</journal-title></journal-title-group><issn pub-type="epub">1660-3397</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31861527</article-id><article-id pub-id-type="pmc">7024264</article-id><article-id pub-id-type="doi">10.3390/md18010005</article-id><article-id pub-id-type="publisher-id">marinedrugs-18-00005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mayer</surname><given-names>Alejandro M. S.</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-18-00005">1</xref><xref rid="c1-marinedrugs-18-00005" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Guerrero</surname><given-names>Aimee J.</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-18-00005">1</xref></contrib><contrib contrib-type="author"><name><surname>Rodríguez</surname><given-names>Abimael D.</given-names></name><xref ref-type="aff" rid="af2-marinedrugs-18-00005">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-8010-0180</contrib-id><name><surname>Taglialatela-Scafati</surname><given-names>Orazio</given-names></name><xref ref-type="aff" rid="af3-marinedrugs-18-00005">3</xref></contrib><contrib contrib-type="author"><name><surname>Nakamura</surname><given-names>Fumiaki</given-names></name><xref ref-type="aff" rid="af4-marinedrugs-18-00005">4</xref></contrib><contrib contrib-type="author"><name><surname>Fusetani</surname><given-names>Nobuhiro</given-names></name><xref ref-type="aff" rid="af5-marinedrugs-18-00005">5</xref></contrib></contrib-group><aff id="af1-marinedrugs-18-00005"><label>1</label>Department of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA;<email>aguerrero89@midwestern.edu</email></aff><aff id="af2-marinedrugs-18-00005"><label>2</label>Molecular Sciences Research Center, University of Puerto Rico, 1390 Ponce de León Avenue, San Juan, PR 00926, USA;<email>abimael.rodriguez1@upr.edu</email></aff><aff id="af3-marinedrugs-18-00005"><label>3</label>Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy;<email>scatagli@unina.it</email></aff><aff id="af4-marinedrugs-18-00005"><label>4</label>Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan;<email>what-will_be.x2@akane.waseda.jp</email></aff><aff id="af5-marinedrugs-18-00005"><label>5</label>Fisheries and Oceans Hakodate, Hakodate 041-8611, Japan;<email>anobu@fish.hokudai.ac.jp</email></aff><author-notes><corresp id="c1-marinedrugs-18-00005"><label>*</label>Correspondence: <email>amayer@midwestern.edu</email>; Tel.: +1-630-515-6951; Fax: +1-630-515-6295</corresp></author-notes><pub-date pub-type="epub"><day>19</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="collection"><month>1</month><year>2020</year></pub-date><volume>18</volume><issue>1</issue><elocation-id>5</elocation-id><history><date date-type="received"><day>27</day><month>11</month><year>2019</year></date><date date-type="accepted"><day>14</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 by the authors.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the <italic>preclinical</italic> marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the <italic>clinical</italic> marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.</p></abstract><kwd-group><kwd>drug</kwd><kwd>marine</kwd><kwd>chemical</kwd><kwd>metabolite</kwd><kwd>natural product</kwd><kwd>pharmacology</kwd><kwd>pharmaceutical</kwd><kwd>review</kwd><kwd>toxicology</kwd><kwd>pipeline</kwd></kwd-group></article-meta></front><floats-group><fig id="marinedrugs-18-00005-f001" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Marine pharmacology in 2014–2015: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic activities.</p></caption><graphic xlink:href="marinedrugs-18-00005-g001a"></graphic><graphic xlink:href="marinedrugs-18-00005-g001b"></graphic><graphic xlink:href="marinedrugs-18-00005-g001c"></graphic><graphic xlink:href="marinedrugs-18-00005-g001d"></graphic><graphic xlink:href="marinedrugs-18-00005-g001e"></graphic><graphic xlink:href="marinedrugs-18-00005-g001f"></graphic><graphic xlink:href="marinedrugs-18-00005-g001g"></graphic><graphic xlink:href="marinedrugs-18-00005-g001h"></graphic><graphic xlink:href="marinedrugs-18-00005-g001i"></graphic><graphic xlink:href="marinedrugs-18-00005-g001j"></graphic><graphic xlink:href="marinedrugs-18-00005-g001k"></graphic></fig><fig id="marinedrugs-18-00005-f002" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Marine pharmacology in 2014–2015: marine compounds with antidiabetic and anti-inflammatory activity, and affecting the immune and nervous system.</p></caption><graphic xlink:href="marinedrugs-18-00005-g002a"></graphic><graphic xlink:href="marinedrugs-18-00005-g002b"></graphic><graphic xlink:href="marinedrugs-18-00005-g002c"></graphic><graphic xlink:href="marinedrugs-18-00005-g002d"></graphic><graphic xlink:href="marinedrugs-18-00005-g002e"></graphic><graphic xlink:href="marinedrugs-18-00005-g002f"></graphic><graphic xlink:href="marinedrugs-18-00005-g002g"></graphic></fig><fig id="marinedrugs-18-00005-f003" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Marine pharmacology in 2014–2015: marine compounds with miscellaneous mechanisms of action.</p></caption><graphic xlink:href="marinedrugs-18-00005-g003a"></graphic><graphic xlink:href="marinedrugs-18-00005-g003b"></graphic><graphic xlink:href="marinedrugs-18-00005-g003c"></graphic><graphic xlink:href="marinedrugs-18-00005-g003d"></graphic><graphic xlink:href="marinedrugs-18-00005-g003e"></graphic><graphic xlink:href="marinedrugs-18-00005-g003f"></graphic><graphic xlink:href="marinedrugs-18-00005-g003g"></graphic><graphic xlink:href="marinedrugs-18-00005-g003h"></graphic><graphic xlink:href="marinedrugs-18-00005-g003i"></graphic></fig><table-wrap id="marinedrugs-18-00005-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">marinedrugs-18-00005-t001_Table 1</object-id><label>Table 1</label><caption><p>Marine pharmacology in 2014–2015: marine compounds with antibacterial, antifungal, antituberculosis, antiprotozoal, antiviral, and anthelmintic activities.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Drug Class</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Compound/Organism <sup>a</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Chemistry</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Pharmacologic Activity</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">IC<sub>50</sub><sup>b</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">MMOA <sup>b</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Country <sup>c</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">axinellamines A and B (<bold>1</bold>, <bold>2</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Gram-positive and negative inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.5–32 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Normal cellular division inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B24-marinedrugs-18-00005" ref-type="bibr">24</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">buanmycin (<bold>3</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. enterica</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.7 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Sortase A inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B25-marinedrugs-18-00005" ref-type="bibr">25</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">cathelicidin (<bold>4</bold>)/sea snake</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Gram-positive and negative inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.16–20.7 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Membrane morphology alteration</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B26-marinedrugs-18-00005" ref-type="bibr">26</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">clavanin A (<bold>5</bold>)/ascidian</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>E. coli</italic> infection inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 mg/kg ***</td><td align="left" valign="middle" rowspan="1" colspan="1">IL-6 and TNF-α inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B27-marinedrugs-18-00005" ref-type="bibr">27</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">gelliusterol E (<bold>6</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. trachomatis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.34 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">OmpA protein inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, GBR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B28-marinedrugs-18-00005" ref-type="bibr">28</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">ianthelliformisamimes B and C (<bold>7</bold>, <bold>8</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Enhanced antibiotics against <italic>E. aerogenes, P. aeruginosa, K. Pneumoniae</italic> MDR strains in vitro </td><td align="left" valign="middle" rowspan="1" colspan="1">3.12–12.5 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Enhancement of drug transporters</td><td align="left" valign="middle" rowspan="1" colspan="1">FRA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B29-marinedrugs-18-00005" ref-type="bibr">29</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">pardaxin (<bold>9</bold>)/flatfish</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>MR S. aureus</italic> inhibition <italic>in vivo</italic></td><td align="left" valign="middle" rowspan="1" colspan="1">8 mg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">MCP-1, IL-6, and TNF-α inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B30-marinedrugs-18-00005" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">phlorofucofuroeckol-A (<bold>10</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>MR S. aureus</italic> inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">32 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PBP2a suppresion</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B31-marinedrugs-18-00005" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">salinamide F (<bold>11</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>E. coli</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.2 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">RNAP inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B32-marinedrugs-18-00005" ref-type="bibr">32</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">piscidins (<bold>12</bold>, <bold>13</bold>)/fish</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>K. pneumonia</italic> and <italic>A. baumannii</italic> inhibition <italic>in vitro</italic></td><td align="left" valign="middle" rowspan="1" colspan="1">1.5–3.1 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B33-marinedrugs-18-00005" ref-type="bibr">33</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">adametizine A (<bold>14</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B34-marinedrugs-18-00005" ref-type="bibr">34</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">agelamadins A and B (<bold>15</bold>, <bold>16</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. luteus</italic> and <italic>C. neoformans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5–8 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B35-marinedrugs-18-00005" ref-type="bibr">35</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. butyrolactone (<bold>17</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>B. cereus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.56 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B36-marinedrugs-18-00005" ref-type="bibr">36</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">aszonapyrone A (<bold>18</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>B. subtilis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">PRT, THAI</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B37-marinedrugs-18-00005" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">austalide R (<bold>19</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Marine bacteria inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.1 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU, GBR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B38-marinedrugs-18-00005" ref-type="bibr">38</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">citrifelin B (<bold>20</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B39-marinedrugs-18-00005" ref-type="bibr">39</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">desmethylisaridin C1 (<bold>21</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>E. coli</italic> inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">8 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B40-marinedrugs-18-00005" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>D. granulosa</italic> diphenyl ethers (<bold>22</bold>, <bold>23</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Gram-positive and negative inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1–16 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B41-marinedrugs-18-00005" ref-type="bibr">41</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">diaporthalasin (<bold>24</bold>) /fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">THAI</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B42-marinedrugs-18-00005" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>D. pulchra</italic> furanones (<bold>25</bold>, <bold>26</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. aeruginosa</italic> biofilm inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.3 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA, FRA, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B43-marinedrugs-18-00005" ref-type="bibr">43</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">aureol B (<bold>27</bold>)/ sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Gram-positive and negative inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B44-marinedrugs-18-00005" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">dysidinoid A (<bold>28</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8 μg/mL **</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B45-marinedrugs-18-00005" ref-type="bibr">45</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Eunicea</italic> sp. compounds (<bold>29</bold>, <bold>30</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. aeruginosa</italic> and <italic>S. aureus</italic> biofilm inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.5 mg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">COL</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B46-marinedrugs-18-00005" ref-type="bibr">46</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">flavipesin A (<bold>31</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>B. subtillis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.25–8 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B47-marinedrugs-18-00005" ref-type="bibr">47</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">gageopeptides A–D (<bold>32–35</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>B. subtillis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.04–0.08 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">BGD, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B48-marinedrugs-18-00005" ref-type="bibr">48</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"> gageotetrins A–C (<bold>36–38</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>B. subtillis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.02–0.04 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">BGD, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B49-marinedrugs-18-00005" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">hormaomycin B (<bold>39</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> and <italic>K. rhizophila</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.4–7 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B50-marinedrugs-18-00005" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">ieodoglucomide C (<bold>40</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Glycolipid</td><td align="left" valign="middle" rowspan="1" colspan="1">Gram-positive and negative inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.01–0.05 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B51-marinedrugs-18-00005" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">isoikarugamycin (<bold>41</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup>/ Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S.aureus</italic></td><td align="left" valign="middle" rowspan="1" colspan="1">2–4 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">ESP</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B52-marinedrugs-18-00005" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">keramadine (<bold>42</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. luteus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, JPN </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B53-marinedrugs-18-00005" ref-type="bibr">53</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Ircinia</italic> sp. secosterols (<bold>43</bold>, <bold>44</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. luteus</italic> and <italic>S. epidermidis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.1, 6.3 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B54-marinedrugs-18-00005" ref-type="bibr">54</xref>,<xref rid="B55-marinedrugs-18-00005" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. dendyi</italic> terpenoids (<bold>45</bold>, <bold>46</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.05–0.29 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B56-marinedrugs-18-00005" ref-type="bibr">56</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">lindgomycin (<bold>47</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5.1 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B57-marinedrugs-18-00005" ref-type="bibr">57</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">marformysin D (<bold>48</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. luteus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.063 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B58-marinedrugs-18-00005" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">mollemycin A (<bold>49</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus and S. epidermidis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.05 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B59-marinedrugs-18-00005" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">neolaurene (<bold>50</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. typhi</italic> and <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">7.5 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">MYS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B60-marinedrugs-18-00005" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" rowspan="1" colspan="1">penicyclone A (<bold>51</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.3 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B61-marinedrugs-18-00005" ref-type="bibr">61</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. oxalicum</italic> enamide (<bold>52</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B62-marinedrugs-18-00005" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">puupehenol (<bold>53</bold>)/ sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>B. cereus</italic> and <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μg/disk <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B63-marinedrugs-18-00005" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">phyllospongin E (<bold>54</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>B. cereus</italic> and <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.5–3.3 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, GBR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B64-marinedrugs-18-00005" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">sarcotrocheliols (<bold>55</bold>, <bold>56</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.5–4.3 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">SAU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B65-marinedrugs-18-00005" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">spiromastixone J (<bold>57</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B66-marinedrugs-18-00005" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">stachyin B (<bold>58</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup> /Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MR <italic>S. aureus</italic> and <italic>B. subtillis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.4–1.7 μM </td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B67-marinedrugs-18-00005" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Streptomyces</italic> sp. glycoside (<bold>59</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. trachomatis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.03 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B68-marinedrugs-18-00005" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">subergosterones A–C (<bold>60–62</bold>)/gorgonian coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>B. cereus</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.6–3.1 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B69-marinedrugs-18-00005" ref-type="bibr">69</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">vitroprocine A (<bold>63</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>A. baumannii</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B70-marinedrugs-18-00005" ref-type="bibr">70</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" rowspan="1" colspan="1">xestospongiamide (<bold>64</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Gram-positive and negative inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.5 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, SAU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B71-marinedrugs-18-00005" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><bold>Antifungal</bold></td><td align="left" valign="middle" rowspan="1" colspan="1">bahamaolide A (<bold>65</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. albicans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.5–3.1 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">ICL inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B72-marinedrugs-18-00005" ref-type="bibr">72</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">heronamide C (<bold>66</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketal/<break></break>alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. pombe</italic> cell inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5.8 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Alteration of membrane microdomains</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B73-marinedrugs-18-00005" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">forazoline A (<bold>67</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. albicans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">16 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Affected membrane integrity</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B74-marinedrugs-18-00005" ref-type="bibr">74</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">aaptamine derivative (<bold>68</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. rubrum</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B75-marinedrugs-18-00005" ref-type="bibr">75</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">amphidinin G (<bold>69</bold>)/dinoflagellate</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. mentagrophytes</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B76-marinedrugs-18-00005" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">amphidinol 18 (<bold>70</bold>)/dinoflagellate</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. albicans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">9 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">ITA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B77-marinedrugs-18-00005" ref-type="bibr">77</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">crambescin homologues (<bold>71–73</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. neoformans</italic> var. <italic>gattii</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.85–2.6 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B78-marinedrugs-18-00005" ref-type="bibr">78</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">coustesides C and D (<bold>74</bold>, <bold>75</bold>)/sea cucumber</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid glycoside <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. albicans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 mg/mL <sup>++</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, S.KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B79-marinedrugs-18-00005" ref-type="bibr">79</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. okamurai</italic> laurenes (<bold>76–78</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. glabrata</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2–4 μg/mL **</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B80-marinedrugs-18-00005" ref-type="bibr">80</xref>,<xref rid="B81-marinedrugs-18-00005" ref-type="bibr">81</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">mohangamide A (<bold>79</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. albicans</italic> isocitrate lyase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.4 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B82-marinedrugs-18-00005" ref-type="bibr">82</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">pleosporallin E (<bold>80</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. albicans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">7.44 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B83-marinedrugs-18-00005" ref-type="bibr">83</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. purpurea</italic> lysophospholipid (<bold>81</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Phospholipid</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. glabrata</italic> and <italic>C. neoformans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B84-marinedrugs-18-00005" ref-type="bibr">84</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">taurospongin A (<bold>82</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. neoformans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B85-marinedrugs-18-00005" ref-type="bibr">85</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">variegatuside D (<bold>83</bold>)/sea cucumber</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid glycoside <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Several <italic>Candida</italic> species inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.4–13.6 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B86-marinedrugs-18-00005" ref-type="bibr">86</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" rowspan="1" colspan="1">xestospongiamide (<bold>64</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>A. niger</italic> and <italic>C. albicans</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>5 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, SAU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B71-marinedrugs-18-00005" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><bold>Antimalarial</bold></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. hooperi</italic> isonitrile (<bold>84</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> D6 and W2 strain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.3–4.7 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">β-hematin inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">USA, ZAF</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B87-marinedrugs-18-00005" ref-type="bibr">87</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1">actinoramide A (<bold>85</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> strains inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.2 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CRI, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B88-marinedrugs-18-00005" ref-type="bibr">88</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1">diacarperoxide J (<bold>86</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> D6 and W2 strain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.6–1.8 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B89-marinedrugs-18-00005" ref-type="bibr">89</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1">laevigatol A (<bold>87</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> NF54 strain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.0 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHE, DEU, S. KOR, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B90-marinedrugs-18-00005" ref-type="bibr">90</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial </td><td align="left" valign="middle" rowspan="1" colspan="1">mollemycin A (<bold>49</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> 3D7and Dd2 strain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">7–9 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B59-marinedrugs-18-00005" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1">mon amphilectines B and C (<bold>88</bold>, <bold>89</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> 3D7strain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">44 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B91-marinedrugs-18-00005" ref-type="bibr">91</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1">netamine K (<bold>90</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.4 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">BEL, FRA, ISR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B92-marinedrugs-18-00005" ref-type="bibr">92</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. ocellata</italic> sesquiterpenes (<bold>91–93</bold>)/nudibranch</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.26–0.3 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, ITA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B93-marinedrugs-18-00005" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antimalarial</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. simplex</italic> polyketide (<bold>94</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. falciparum</italic> D10 and W2 strain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.7–4.0 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, ITA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B94-marinedrugs-18-00005" ref-type="bibr">94</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><bold>Antiprotozoal</bold></td><td align="left" valign="middle" rowspan="1" colspan="1">plakortide E (<bold>95</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. brucei</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Rhodesain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B95-marinedrugs-18-00005" ref-type="bibr">95</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">batzelladine L (<bold>96</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. cruzi</italic> and <italic>L. infantum</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Enhanced ROS generation</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA, CAN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B96-marinedrugs-18-00005" ref-type="bibr">96</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">actinoporin A (<bold>97</bold>)/ bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. b. brucei</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">15 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, DEU, EGY, GBR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B97-marinedrugs-18-00005" ref-type="bibr">97</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">astropectenol A (<bold>98</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. brucei</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.6 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">DEU, VNM, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B98-marinedrugs-18-00005" ref-type="bibr">98</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>H. simulans</italic> sterol (<bold>99</bold>) sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. b. brucei</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.6 μM <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IRL, GBR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B99-marinedrugs-18-00005" ref-type="bibr">99</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">lobosamide A (<bold>100</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. b. brucei</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.8 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B100-marinedrugs-18-00005" ref-type="bibr">100</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">lobocrasols A and C (<bold>101</bold>, <bold>102</bold>)/soft corals</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. donovani</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.18 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHE, DEU, S. KOR, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B90-marinedrugs-18-00005" ref-type="bibr">90</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">mangromicin A (<bold>103</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. b. brucei</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.44 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B101-marinedrugs-18-00005" ref-type="bibr">101</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">crassumols D and E (<bold>104</bold>, <bold>105</bold>)/soft corals</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>T. b. rhodesiense</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.61 and 0.72 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHE, DEU, S. KOR, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B90-marinedrugs-18-00005" ref-type="bibr">90</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">sesterstamide (<bold>106</bold>)/sponge </td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. donovani</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">32.9 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B102-marinedrugs-18-00005" ref-type="bibr">102</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiprotozoal</td><td align="left" valign="middle" rowspan="1" colspan="1">shagene A (<bold>107</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. donovani</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B103-marinedrugs-18-00005" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><bold>Antituberculosis</bold></td><td align="left" valign="middle" rowspan="1" colspan="1">aaptamine analog (<bold>108</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. smegmatis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">6.25 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B104-marinedrugs-18-00005" ref-type="bibr">104</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antituberculosis</td><td align="left" valign="middle" rowspan="1" colspan="1">callyaerins A and B (<bold>109</bold>, <bold>110</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. tuberculosis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2, 5 μM **</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B105-marinedrugs-18-00005" ref-type="bibr">105</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antituberculosis</td><td align="left" valign="middle" rowspan="1" colspan="1">denigrin C (<bold>111</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. tuberculosis</italic> H<sub>37</sub>Rv inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μg/mL <sup>+</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IND</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B106-marinedrugs-18-00005" ref-type="bibr">106</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antituberculosis</td><td align="left" valign="middle" rowspan="1" colspan="1">oxazinin A (<bold>112</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>M. tuberculosis</italic> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.9 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B107-marinedrugs-18-00005" ref-type="bibr">107</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><bold>Antiviral</bold></td><td align="left" valign="middle" rowspan="1" colspan="1">pateamine A (<bold>113</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Mixed Biogenesis</td><td align="left" valign="middle" rowspan="1" colspan="1">Sindbis virus mRNA translation inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>100 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">nsP1 or nsP2 viral protein synthesis inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">CAN, ESP, NZL </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B108-marinedrugs-18-00005" ref-type="bibr">108</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">abyssomicin 2 (<bold>114</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 reactivation</td><td align="left" valign="middle" rowspan="1" colspan="1">13.9 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Increased viral RNA in CD4<sup>+</sup> T cells</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B109-marinedrugs-18-00005" ref-type="bibr">109</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">8,4′’’-dieckol (<bold>115</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM * </td><td align="left" valign="middle" rowspan="1" colspan="1">Reverse transcriptase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B110-marinedrugs-18-00005" ref-type="bibr">110</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">truncateol M (<bold>116</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">H1N1 influenza A virus inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8.8 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Virion assembly/release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B111-marinedrugs-18-00005" ref-type="bibr">111</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">neoechinulin B (<bold>117</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">H3N2, H1N1 A influenza virus inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">17-22 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Hemagglutinin inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B112-marinedrugs-18-00005" ref-type="bibr">112</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">thaixylomolin I (<bold>118</bold>)/mangrove</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">H1N1 influenza A virus inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">77 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU, THAI</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B113-marinedrugs-18-00005" ref-type="bibr">113</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">aaptamine derivative (<bold>68</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B75-marinedrugs-18-00005" ref-type="bibr">75</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral </td><td align="left" valign="middle" rowspan="1" colspan="1">aflaquinolone B derivative (<bold>119</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Mixed biogenesis</td><td align="left" valign="middle" rowspan="1" colspan="1">RSV inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.042 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B114-marinedrugs-18-00005" ref-type="bibr">114</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>A. terreus</italic> lactones (<bold>120</bold>, <bold>121</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HSV-1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">6.34 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B115-marinedrugs-18-00005" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">chartarutine B (<bold>122</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup>/terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.9 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B116-marinedrugs-18-00005" ref-type="bibr">116</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">debromoaplysiatoxin (<bold>123</bold>)/cyanobacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">CHIKV inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.4 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">NZL, SGP</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B117-marinedrugs-18-00005" ref-type="bibr">117</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">dolabelladienol A (<bold>124</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.9 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA, COL, ESP</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B118-marinedrugs-18-00005" ref-type="bibr">118</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>D. plectens</italic> diterpene (<bold>125</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">16.1 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B119-marinedrugs-18-00005" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Dysidea</italic> sp. PBDEs (<bold>22</bold>, <bold>23</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Hepatitis B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.23–0.80 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Core promoter inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">IDN, JPN, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B120-marinedrugs-18-00005" ref-type="bibr">120</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">echrebsteroid C (<bold>126</bold>)/gorgonian</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">RSV inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.19 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B121-marinedrugs-18-00005" ref-type="bibr">121</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">(+)-pestaloxazine A (<bold>127</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Enterovirus 71 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">14.2 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B122-marinedrugs-18-00005" ref-type="bibr">122</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral </td><td align="left" valign="middle" rowspan="1" colspan="1">phlorofucofuroeckol-A(<bold>10</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">MNV inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.9 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B123-marinedrugs-18-00005" ref-type="bibr">123</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">secocrassumol (<bold>128</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HCMV inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B124-marinedrugs-18-00005" ref-type="bibr">124</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">sporolide B (<bold>129</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-reverse transcriptase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">14 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IND</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B125-marinedrugs-18-00005" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">stellettapeptins A and B (<bold>130</bold>, <bold>131</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HIV-1 infection inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">23–27 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B126-marinedrugs-18-00005" ref-type="bibr">126</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" rowspan="1" colspan="1">trichobotrysin A (<bold>132</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup> /Alkaloid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HSV-1 inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">3.08 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B127-marinedrugs-18-00005" ref-type="bibr">127</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><bold>Anthelmintic</bold></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">phorioadenine A (<bold>133</bold>)/sponge</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alkaloid <sup>f</sup></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>H. contortus</italic> inhibition</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">31 μg/mL <sup>+++</sup></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AUS</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B128-marinedrugs-18-00005" ref-type="bibr">128</xref>]</td></tr></tbody></table><table-wrap-foot><fn><p><bold><sup>a</sup> Organism</bold>: <italic>Kingdom Animalia</italic>: ascidian, flatfish, sea snakes (Phylum Chordata), gorgonian, coral (Phylum Cnidaria), sea cucumber (Phylum Echinodermata), nudibranch (Phylum Mollusca), sponge (Phylum Porifera); <italic>Kingdom Monera</italic>: bacterium (Phylum Cyanobacteria); <italic>Kingdom Fungi</italic>: fungus; <italic>Kingdom Plantae:</italic> alga, mangrove, seagrass; <italic>Kingdom Protista</italic>: dinoflagellates; <bold><sup>b</sup> IC<sub>50</sub></bold>: concentration of a compound required for 50% inhibition in vitro, *: estimated IC<sub>50</sub>, **: MIC<sub>80</sub>, MIC<sub>90</sub>, or IC<sub>90</sub>, ***: in vivo study; <sup>+</sup> MIC: minimum inhibitory concentration, <sup>++</sup> MID: minimum inhibitory concentration per disk; <sup>+++</sup> LC<sub>90</sub>: concentration of a compound required for 90% lethality; <bold><sup>b</sup> MMOA</bold>: molecular mechanism of action; <bold><sup>c</sup> Country</bold>: AUS: Australia; BEL: Belgium; BGD: Bangladesh; BRA: Brazil; CAN: Canada; CHE: Switzerland; CHN: China; COL: Colombia; CRI: Costa Rica; DEU: Germany; EGY: Egypt; ESP: Spain; FRA: France; GBR: United Kingdom; IDN: Indonesia; IND: India; IRL: Ireland; ISR: Israel; ITA: Italy; JPN: Japan; MYS: Malaysia; NLD: The Netherlands; NZL: New Zealand; PRT: Portugal; SAU: Saudi Arabia; SGP: Singapore; S. KOR: South Korea; THAI: Thailand; TWN: Taiwan; VNM: Vietnam; ZAF: S. Africa; <bold>Chemistry: <sup>d</sup></bold> polyketide; <bold><sup>e</sup></bold> terpene; <bold><sup>f</sup></bold> nitrogen-containing compound; <bold><sup>g</sup></bold> polysaccharide; <bold><sup>h</sup></bold> shikimate; <bold>Abbreviations:</bold> CHIKV: chikungunya virus; HCMV: human cytomegalovirus; MNV: murine norovirus; HSV: herpes simplex virus; ICL: isocitrate lyase; MR: methicillin-resistant; PBP2a: penicillin-binding protein 2a; RNAP: RNA-polymerase; RSV: respiratory syncytial virus; TNF-α: tumor necrosis factor α.</p></fn></table-wrap-foot></table-wrap><table-wrap id="marinedrugs-18-00005-t002" orientation="portrait" position="float"><object-id pub-id-type="pii">marinedrugs-18-00005-t002_Table 2</object-id><label>Table 2</label><caption><p>Marine pharmacology in 2014–2015: marine compounds with antidiabetic and anti-inflammatory activity, and affecting the immune and nervous system.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Drug Class</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Compound/Organism <sup>a+</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Chemistry</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Pharmacological Activity</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">IC<sub>50</sub><sup>b</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">MMOA <sup>c</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Country <sup>d</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">fucoxanthin and fucoxanthinol (<bold>134</bold>, <bold>135</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Improved glucose tolerance in vitro and in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">50 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Cytokine inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B154-marinedrugs-18-00005" ref-type="bibr">154</xref>,<xref rid="B155-marinedrugs-18-00005" ref-type="bibr">155</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">octaphlorethol A (<bold>136</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">α-glucosidase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">110 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Molecular docking on active site</td><td align="left" valign="middle" rowspan="1" colspan="1">CAN, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B156-marinedrugs-18-00005" ref-type="bibr">156</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">phlorofucofuroeckol-A (<bold>10</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Decreased glucose levels in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">10 mg/kg **</td><td align="left" valign="middle" rowspan="1" colspan="1">α-glucosidase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B157-marinedrugs-18-00005" ref-type="bibr">157</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">Con-Ins G1 (<bold>137</bold>)/cone snail</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Hypoglycemia induction</td><td align="left" valign="middle" rowspan="1" colspan="1">65 ng/g *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, DNK, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B158-marinedrugs-18-00005" ref-type="bibr">158</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">dehydroeuryspongin A (<bold>138</bold>)/sponge </td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.58 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IDN, JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B159-marinedrugs-18-00005" ref-type="bibr">159</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Epicoccum</italic> sp. diterpene (<bold>139</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">α-glucosidase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.6 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B160-marinedrugs-18-00005" ref-type="bibr">160</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">suncheonoside A (<bold>140</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Adiponectin production</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B161-marinedrugs-18-00005" ref-type="bibr">161</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1">terrelumamide A (<bold>141</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Adiponectin production</td><td align="left" valign="middle" rowspan="1" colspan="1">37 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B162-marinedrugs-18-00005" ref-type="bibr">162</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Antidiabetic</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>X. testudinaria</italic> lipid (<bold>142</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5.3 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B163-marinedrugs-18-00005" ref-type="bibr">163</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">alcyonolide congeners (<bold>143</bold>, <bold>144</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B164-marinedrugs-18-00005" ref-type="bibr">164</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">astaxanthin (<bold>145</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Oxidative stress inhibition in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">10 mg/kg **</td><td align="left" valign="middle" rowspan="1" colspan="1">CAT and SOD enhancement</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B165-marinedrugs-18-00005" ref-type="bibr">165</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">8,8′-bieckol (<bold>146</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO and PGE<sub>2</sub> release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">50 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Inhibition of NFκB</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B166-marinedrugs-18-00005" ref-type="bibr">166</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">convolutamydine A (<bold>147</bold>)/ bryozoa</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Formalin-induced licking behavior inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.01 mg/kg *</td><td align="left" valign="middle" rowspan="1" colspan="1">TNF-α, IL-6 release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B167-marinedrugs-18-00005" ref-type="bibr">167</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">capgermacrene A (<bold>148</bold>)/ soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO and IL-1β inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1"><10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">MYS, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B168-marinedrugs-18-00005" ref-type="bibr">168</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">cathelicidin (<bold>4</bold>)/sea snake</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Binding of LPS to TLR4 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Inflammatory cytokine inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B26-marinedrugs-18-00005" ref-type="bibr">26</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">dactyloditerpenol acetate (<bold>149</bold>)/ sea hare</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">LPS- activated microglia in vitro inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.4–1 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">O<sub>2</sub><sup>-</sup> and TXB<sub>2</sub> inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B169-marinedrugs-18-00005" ref-type="bibr">169</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">dieckol (<bold>150</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage iNOS transcription inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">30 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Inhibition of NFκB and p38MAPK </td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B170-marinedrugs-18-00005" ref-type="bibr">170</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">dieckol (<bold>150</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Human keratinocyte MDC/CCL22 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">12.5 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">STAT1 phosphorylation inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B171-marinedrugs-18-00005" ref-type="bibr">171</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">excavatolide B (<bold>151</bold>)/gorgonian</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage iNOS and COX-2 transcription inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">25 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">In vivo iNOS protein expression reduction</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B172-marinedrugs-18-00005" ref-type="bibr">172</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">flexibilide (<bold>152</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neuropathic pain inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 µg *</td><td align="left" valign="middle" rowspan="1" colspan="1">Upregulation of TGF-β1</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B173-marinedrugs-18-00005" ref-type="bibr">173</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">fucoxanthinol (<bold>135</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage TNF-α and MCP-1 release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">COX-2 expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B155-marinedrugs-18-00005" ref-type="bibr">155</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>H. fusiforme</italic> flavone (<bold>153</bold>)/ alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup>/Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO and PGE<sub>2</sub> release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS, COX-2 expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B174-marinedrugs-18-00005" ref-type="bibr">174</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">5β-hydroxypalisadin B (<bold>154</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">17 μM </td><td align="left" valign="middle" rowspan="1" colspan="1">Partial iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">LKA, MYS, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B175-marinedrugs-18-00005" ref-type="bibr">175</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">glaucumolides A and B (<bold>155</bold>, <bold>156</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.8–4 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS, COX-2 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B176-marinedrugs-18-00005" ref-type="bibr">176</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">phlorofucofuroeckol-B (<bold>157</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Microglia activation inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.1 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS, COX-2 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B177-marinedrugs-18-00005" ref-type="bibr">177</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. palmata</italic> lipid (<bold>158</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">16.7 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CAN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B178-marinedrugs-18-00005" ref-type="bibr">178</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">reduced scytonemin (<bold>159</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">HO-1 expression induction</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B179-marinedrugs-18-00005" ref-type="bibr">179</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">sinuleptolide (<bold>160</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">LPS-activated rat microglia in vitro inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.5–2.9 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Cytokine release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">ESP, FIN, IND, ITA, </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B180-marinedrugs-18-00005" ref-type="bibr">180</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">sarcopanol A (<bold>161</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS, COX-2, and ICAM-1 transcription inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8.3 µM </td><td align="left" valign="middle" rowspan="1" colspan="1">NFκB inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B181-marinedrugs-18-00005" ref-type="bibr">181</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">sinumaximol H (<bold>162</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS and ICAM-1 transcription inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">NFκB inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B182-marinedrugs-18-00005" ref-type="bibr">182</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">tanzawaic acid A (<bold>163</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">NO inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">7.1 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS and PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">VNM, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B183-marinedrugs-18-00005" ref-type="bibr">183</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">aspertetranone D (<bold>164</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">IL-6 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">40 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B184-marinedrugs-18-00005" ref-type="bibr">184</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">briarenolide J (<bold>165</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10–15 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B185-marinedrugs-18-00005" ref-type="bibr">185</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">briarenolides K and L (<bold>166</bold>, <bold>167</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage iNOS inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B186-marinedrugs-18-00005" ref-type="bibr">186</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">briarenolides U, V, W (<bold>168</bold>, <bold>169</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage COX-2 and iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B187-marinedrugs-18-00005" ref-type="bibr">187</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">briaviolides E and I (<bold>170</bold>, <bold>171</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B188-marinedrugs-18-00005" ref-type="bibr">188</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">dermacozine H (<bold>172</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Radical scavenging activity</td><td align="left" valign="middle" rowspan="1" colspan="1">18.8 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">DEU, EGY, UK</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B189-marinedrugs-18-00005" ref-type="bibr">189</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">dysifragilone A (<bold>173</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">6.6 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B190-marinedrugs-18-00005" ref-type="bibr">190</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>D. plectens</italic> xenicane (<bold>174</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO release inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B191-marinedrugs-18-00005" ref-type="bibr">191</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">comaparvin (<bold>175</bold>)/crinoid</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Carrageenan-induced hyperalgesia inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">30 mg/kg *</td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B192-marinedrugs-18-00005" ref-type="bibr">192</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">hirsutalins N and S (<bold>176</bold>, <bold>177</bold>)/ soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B193-marinedrugs-18-00005" ref-type="bibr">193</xref>,<xref rid="B194-marinedrugs-18-00005" ref-type="bibr">194</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">hirsutocospiro A (<bold>178</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.7–4.1 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B195-marinedrugs-18-00005" ref-type="bibr">195</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">isosinulaflexiolide K (<bold>179</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage COX-2 and iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B196-marinedrugs-18-00005" ref-type="bibr">196</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">klyflaccisteroid F (<bold>180</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.34 μM </td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B197-marinedrugs-18-00005" ref-type="bibr">197</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">krempfielin N (<bold>181</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B198-marinedrugs-18-00005" ref-type="bibr">198</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">krempfielins Q and R (<bold>182</bold>, <bold>183</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B199-marinedrugs-18-00005" ref-type="bibr">199</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">methylfarnesylquinone (<bold>184</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup>/Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX and elastase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.2–0.48 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B200-marinedrugs-18-00005" ref-type="bibr">200</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">monanchosterol B (<bold>185</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage IL-6 expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B201-marinedrugs-18-00005" ref-type="bibr">201</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>P. nodosus</italic> sterol (<bold>186</bold>)/starfish </td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">IL-12 and IL-6 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.3–3.1 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">VNM, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B202-marinedrugs-18-00005" ref-type="bibr">202</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">rhytidenone C (<bold>187</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.31 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">THA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B203-marinedrugs-18-00005" ref-type="bibr">203</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">sarcocrassocolide E (<bold>188</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage COX-2 and iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1"><10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B204-marinedrugs-18-00005" ref-type="bibr">204</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">sinulacembranolide A (<bold>189</bold>)/octocoral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage iNOS expression inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1"><10 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B205-marinedrugs-18-00005" ref-type="bibr">205</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">thomimarine B (<bold>190</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">>10 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B206-marinedrugs-18-00005" ref-type="bibr">206</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" rowspan="1" colspan="1">tortuosene A (<bold>191</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neutrophil SOX inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">7.3 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B207-marinedrugs-18-00005" ref-type="bibr">207</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Immune system</td><td align="left" valign="middle" rowspan="1" colspan="1">grassypeptolide A (<bold>192</bold>)/cyanobacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">IL-2 and T-cell proliferation inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Dipeptidyl peptidase 8 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, JPN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B208-marinedrugs-18-00005" ref-type="bibr">208</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Immune system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>F. reticulata</italic> alkaloids (<bold>193</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">IL-2 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5–50 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B209-marinedrugs-18-00005" ref-type="bibr">209</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Immune system</td><td align="left" valign="middle" rowspan="1" colspan="1">luzonicoside A (<bold>194</bold>)/starfish</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage NO and ROS stimulation</td><td align="left" valign="middle" rowspan="1" colspan="1">0.01–0.1 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS, VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B210-marinedrugs-18-00005" ref-type="bibr">210</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Immune system</td><td align="left" valign="middle" rowspan="1" colspan="1">typicoside C1(<bold>195</bold>)/sea cucumber</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage ROS stimulation</td><td align="left" valign="middle" rowspan="1" colspan="1"><1 ng/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IND, RUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B211-marinedrugs-18-00005" ref-type="bibr">211</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><bold>Nervous system</bold></td><td align="left" valign="middle" rowspan="1" colspan="1">aurone glycoside (<bold>196</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup>/Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Oxidative stress neuroprotection</td><td align="left" valign="middle" rowspan="1" colspan="1">1 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Apoptosis inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B212-marinedrugs-18-00005" ref-type="bibr">212</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">azaspiracid-1 (<bold>197</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup>/<break></break>Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Peripherin-labelled neurite process</td><td align="left" valign="middle" rowspan="1" colspan="1">15 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Peripherin isoform downregulation</td><td align="left" valign="middle" rowspan="1" colspan="1">NOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B213-marinedrugs-18-00005" ref-type="bibr">213</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">caulerpine (<bold>198</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Antinociceptive activity</td><td align="left" valign="middle" rowspan="1" colspan="1">40 mg/kg *</td><td align="left" valign="middle" rowspan="1" colspan="1">Involves α2 and 5-HT<sub>3</sub> receptors</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B214-marinedrugs-18-00005" ref-type="bibr">214</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous systema</td><td align="left" valign="middle" rowspan="1" colspan="1">6-bromohypaphorine (<bold>199</bold>)/sea slug</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Human α7 nAChR agonist</td><td align="left" valign="middle" rowspan="1" colspan="1">23 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Rise [Ca<sup>2+</sup> ]i</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B215-marinedrugs-18-00005" ref-type="bibr">215</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">piscidin (<bold>200</bold>)/fish</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Antinociceptive activity</td><td align="left" valign="middle" rowspan="1" colspan="1">20 µg/rat *</td><td align="left" valign="middle" rowspan="1" colspan="1">Phosphor-mTOR inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B216-marinedrugs-18-00005" ref-type="bibr">216</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. marmoreus</italic> conotoxin Mr1.7 (<bold>201</bold>)/cone snail</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Ach-evoked membrane current inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">53.1 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">A3β2 nAChR inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B217-marinedrugs-18-00005" ref-type="bibr">217</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. litteratus</italic> conotoxin lt16a (<bold>202</bold>)/cone snail</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neuronal Na<sup>+</sup> current inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B218-marinedrugs-18-00005" ref-type="bibr">218</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. vitulinus</italic> peptide (<bold>203</bold>)/ cone snail</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Neuronal BK channel inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8.5 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Electrostatic interaction with β4 subunits</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B219-marinedrugs-18-00005" ref-type="bibr">219</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">echinochrome A (<bold>204</bold>)/sea urchin</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Acetylcholinesterase inhibition and NO scavenging</td><td align="left" valign="middle" rowspan="1" colspan="1">16.4 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Irreversible and uncompetitive inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR, RUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B220-marinedrugs-18-00005" ref-type="bibr">220</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">ganglioside LLG-3 (<bold>205</bold>)/starfish</td><td align="left" valign="middle" rowspan="1" colspan="1">Glycolipid</td><td align="left" valign="middle" rowspan="1" colspan="1">Neuritogenesis stimulation in vitro</td><td align="left" valign="middle" rowspan="1" colspan="1">1 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">MAPK signaling stimulation</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B221-marinedrugs-18-00005" ref-type="bibr">221</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">heteronemin (<bold>206</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">TDP-43 binding to DNA inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10.1 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Promoted aggregation of insoluble TDP-43</td><td align="left" valign="middle" rowspan="1" colspan="1">ITA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B222-marinedrugs-18-00005" ref-type="bibr">222</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">pinnatoxin A (<bold>207</bold>)/mollusc</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup>/<break></break>Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Muscle and neuronal nAChRs receptor inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.086–47.5 nM </td><td align="left" valign="middle" rowspan="1" colspan="1">EF-ketal ring confers nAChR subtype specificity</td><td align="left" valign="middle" rowspan="1" colspan="1">FRA, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B223-marinedrugs-18-00005" ref-type="bibr">223</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous tissue</td><td align="left" valign="middle" rowspan="1" colspan="1">PhcrTx1 (<bold>208</bold>)/sea anemone</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">ASIC inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">100 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Lower potency on Kv channels</td><td align="left" valign="middle" rowspan="1" colspan="1">BEL, BRA, CUB, DEU, ESP, MEX </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B224-marinedrugs-18-00005" ref-type="bibr">224</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous tissue</td><td align="left" valign="middle" rowspan="1" colspan="1">phlorofucofuroeckol-A (<bold>10</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Butyrylcholinesterase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.95 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">β-secretase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B225-marinedrugs-18-00005" ref-type="bibr">225</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous tissue</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. auritum</italic> ceramide (<bold>209</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Anxiolytic and CNS depressing activity in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">1 mg/kg **</td><td align="left" valign="middle" rowspan="1" colspan="1">GABA(A) receptor modulation</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B226-marinedrugs-18-00005" ref-type="bibr">226</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">spirolide C (<bold>210</bold>)/dinoflagellate</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup>/<break></break>Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">nAChR inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1.5–3 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Muscle and neuronal -type nAChR inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">FRA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B227-marinedrugs-18-00005" ref-type="bibr">227</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">zonarol (<bold>211</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Meroterpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Glutamate toxicity inhibition in vitro</td><td align="left" valign="middle" rowspan="1" colspan="1">0.22 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Nrf2/ARE pathway activation</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B228-marinedrugs-18-00005" ref-type="bibr">228</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">aplysinellamide-1 (<bold>212</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">ApoE secretion modulation</td><td align="left" valign="middle" rowspan="1" colspan="1">30 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, CAN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B229-marinedrugs-18-00005" ref-type="bibr">229</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>A. terreus</italic> lactones (<bold>120</bold>, <bold>121</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">acetylcholinesterase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.2 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B115-marinedrugs-18-00005" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. araneosus</italic> ar3j conotoxin (<bold>213</bold>)/cone snail</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Sleep induction</td><td align="left" valign="middle" rowspan="1" colspan="1">2 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IND</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B230-marinedrugs-18-00005" ref-type="bibr">230</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>D. cejpii</italic> steroid (<bold>214</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Amyloid β-42 production inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">DEU, FRA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B231-marinedrugs-18-00005" ref-type="bibr">231</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">genuanine (<bold>215</bold>)/cone snail</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Paralysis in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">40 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">PRT, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B232-marinedrugs-18-00005" ref-type="bibr">232</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">homoaerothionin (<bold>216</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">acetylcholinesterase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.9–6.2 µM </td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">THA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B233-marinedrugs-18-00005" ref-type="bibr">233</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" rowspan="1" colspan="1">mooreamide A (<bold>217</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>d</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">CB<sub>1</sub> binding</td><td align="left" valign="middle" rowspan="1" colspan="1">0.47 µM **</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">ITA, PNG, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B234-marinedrugs-18-00005" ref-type="bibr">234</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nervous system</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>S. spinosulus</italic> hydroquinone (<bold>218</bold>)/sponge</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shikimate <sup>h</sup>/Polyketide <sup>d</sup></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Enhance glutamate and ACh release</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µM *</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ITA</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B235-marinedrugs-18-00005" ref-type="bibr">235</xref>]</td></tr></tbody></table><table-wrap-foot><fn><p><sup>a</sup><bold>Organism:</bold><italic>Kingdom Animalia</italic>: fish (Phylum Chordata); bryozoan; coral and sea anemone (Phylum Cnidaria); crinoid, sea urchin, starfish (Phylum Echinodermata); cone snail, sea slug (Phylum Mollusca); sponge (Phylum Porifera); <italic>Kingdom Fungi</italic>: fungus; <italic>Kingdom Plantae:</italic> alga; <italic>Kingdom Monera</italic>: bacterium; <italic>Kingdom Protozoa</italic>: dinoflagellates; <sup>b</sup><bold>IC<sub>50</sub></bold>: concentration of a compound required for 50% inhibition, *: apparent IC<sub>50</sub>, **: in vivo study; **: <italic>K</italic><sub>i</sub>: concentration needed to reduce the activity of an enzyme by half; <sup>c</sup><bold>MMOA:</bold> molecular mechanism of action; <sup>d</sup><bold>Country:</bold> AUS: Australia; BEL: Belgium; BRA: Brazil; CAN: Canada; CHN: China; CUB: Cuba; DEU: Germany; DNK: Denmark; EGY: Egypt; ESP: Spain; FIN, Finland; FRA: France; IDN: Indonesia; IND, India; ITA: Italy; JPN: Japan; LKA: Sri Lanka; MEX: Mexico; MYS: Malaysia; NLD: Netherlands; NOR: Norway; PNG: Papua New Guinea; PRT: Portugal; RUS: Russian Federation; S. KOR: South Korea; THA: Thailand; TWN: Taiwan; VNM: Vietnam; <bold>Chemistry:</bold><sup>e</sup> Polyketide; <sup>f</sup> Terpene; <sup>g</sup> Nitrogen-containing compound; <sup>h</sup> Shikimate. <bold>Abbreviations:</bold> Ach: acetylcholine; ApoE: apolipoprotein E; ASIC: acid-sensing sodium ion channel; CAT: catalase; CB<sub>1</sub>: cannabinoid receptor 1; CNS: central nervous system; COX: cyclooxygenase; HO-1: heme oxygenase-1; ICAM: intercellular adhesion molecule-1; IL: interleukin; iNOS: inducible nitric oxide synthase; Kv current: voltage-gated K+ current; MAPK: mitogen-activated protein kinase pathway; MDC/CCL22: macrophage-derived chemokine, C–C motif chemokine 22; nAChR: nicotinic acetylcholine receptor; NA: not available; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NO: nitric oxide; nAChR: nicotinic acetylcholine receptor; Nrf2-ARE: nuclear transcription factor E2-related factor antioxidant response element; PTP1B: tyrosine protein; phosphatase 1B; ROS: reactive oxygen species; SOD: superoxide dismutase; SOX: superoxide; STAT1: signal transducer and activator of transcription1; TDP-43: trans-activation response DNA-binding protein of 43 kDa.</p></fn></table-wrap-foot></table-wrap><table-wrap id="marinedrugs-18-00005-t003" orientation="portrait" position="float"><object-id pub-id-type="pii">marinedrugs-18-00005-t003_Table 3</object-id><label>Table 3</label><caption><p>Marine pharmacology in 2014–2015: marine compounds with miscellaneous mechanisms of action.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Compound/Organism <sup>a</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Chemistry</th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Pharmacological Activity <sup>i</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">IC<sub>50</sub><sup>b</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">MMOA <sup>c</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Country <sup>d</sup></th><th align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1">AdE-1 (<bold>219</bold>)/sea anemone</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Cardiomyocyte action potential modulation</td><td align="left" valign="middle" rowspan="1" colspan="1">2 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Na<sup>+</sup> and K<sup>+</sup> current increase</td><td align="left" valign="middle" rowspan="1" colspan="1">ISR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B236-marinedrugs-18-00005" ref-type="bibr">236</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">aaptamine (<bold>220</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">ROS inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Cytokine inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B237-marinedrugs-18-00005" ref-type="bibr">237</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">amphirionin-4 (<bold>221</bold>)/dinoflagellate</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Bone marrow stromal cells proliferation stimulation</td><td align="left" valign="middle" rowspan="1" colspan="1"><0.1 ng/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Cytoskeleton protein synthesis</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B238-marinedrugs-18-00005" ref-type="bibr">238</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">astaxanthin (<bold>145</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Leydig cell steroidogenesis protection</td><td align="left" valign="middle" rowspan="1" colspan="1">10 µg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">ROS scavenging</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B239-marinedrugs-18-00005" ref-type="bibr">239</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">bastadins 6 and 16 (<bold>222</bold>, <bold>223</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Foam cell formation inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">5 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">ACAT inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B240-marinedrugs-18-00005" ref-type="bibr">240</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">6,6-bieckol (<bold>224</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Adipocyte differentiation inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">50 µg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Adipogenesis inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B241-marinedrugs-18-00005" ref-type="bibr">241</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">(-)-chlorizidine A (<bold>225</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Increase G<sub>1</sub> cell cycle phase</td><td align="left" valign="middle" rowspan="1" colspan="1">2 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">GAPDH and hENO1 binding</td><td align="left" valign="middle" rowspan="1" colspan="1">BRA, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B242-marinedrugs-18-00005" ref-type="bibr">242</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">dihydroaustrasulfone alcohol (<bold>226</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PDGF-induced HASMC proliferation and angiogenesis inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">DNA synthesis and VEGF signaling inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B243-marinedrugs-18-00005" ref-type="bibr">243</xref>,<xref rid="B244-marinedrugs-18-00005" ref-type="bibr">244</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">DPHC (<bold>227</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">UVB radiation-induced DNA damage protection</td><td align="left" valign="middle" rowspan="1" colspan="1">20 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Nucleotide excision repair system induction</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B245-marinedrugs-18-00005" ref-type="bibr">245</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">echinochrome A (<bold>204</bold>)/sea urchin</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Cardiac contractility inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">SERCA2A inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">BEL, S. KOR, RUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B246-marinedrugs-18-00005" ref-type="bibr">246</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">echinochrome A (<bold>204</bold>)/sea urchin</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Increased mitochondria biogenesis and function</td><td align="left" valign="middle" rowspan="1" colspan="1">5 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Mitochondrial biogenesis genes upregulation</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR, RUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B247-marinedrugs-18-00005" ref-type="bibr">247</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">eckol (<bold>228</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">ROS suppression in cells</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Increased HO-1 expression</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B248-marinedrugs-18-00005" ref-type="bibr">248</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">emindole SB (<bold>229</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Nonselective CB<sub>1</sub>/CB<sub>2</sub> antagonist</td><td align="left" valign="middle" rowspan="1" colspan="1">2.2–7.0 μM **</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHE, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B249-marinedrugs-18-00005" ref-type="bibr">249</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">farnesylquinone (<bold>230</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Decreased lipid accumulation </td><td align="left" valign="middle" rowspan="1" colspan="1">1 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Increased PPARα activity</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B250-marinedrugs-18-00005" ref-type="bibr">250</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">FGFC1 (<bold>231</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Thrombolysis induction in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">5 mg/kg *</td><td align="left" valign="middle" rowspan="1" colspan="1">Fibrin hydrolysis induction<break></break>in vitro</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B251-marinedrugs-18-00005" ref-type="bibr">251</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">formosusin A (<bold>232</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Mammalian DNA polymerase β inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">35.6 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Competitive and non-competitive inhibition </td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B252-marinedrugs-18-00005" ref-type="bibr">252</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">fucodiphlorethol (<bold>233</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">ROS inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Decreased mitochondrial loss, and caspase-9 expression</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B253-marinedrugs-18-00005" ref-type="bibr">253</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">gallic acid (<bold>234</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">NO-dependent vasorelaxant effect</td><td align="left" valign="middle" rowspan="1" colspan="1">12.5 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Phospho-eNOS increase </td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B254-marinedrugs-18-00005" ref-type="bibr">254</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">gallinamide A (<bold>235</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Human cathepsin L inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Covalent inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B255-marinedrugs-18-00005" ref-type="bibr">255</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">girolline (<bold>236</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">TLR 5 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">IL-8 and IL-6 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">CAN, NLD, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B256-marinedrugs-18-00005" ref-type="bibr">256</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">gracilins A, H, L (<bold>237–239</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">mPTP opening inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">1 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Binding to CypD</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, ESP, GBR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B257-marinedrugs-18-00005" ref-type="bibr">257</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>H. crispa</italic> polypeptides (<bold>240</bold>, <bold>241</bold>)/sea anemone</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Macrophage TNF-α, IL-6, and proIL-1β inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1"></td><td align="left" valign="middle" rowspan="1" colspan="1">Trypsin and α-chemotrypsin inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS, TWN </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B258-marinedrugs-18-00005" ref-type="bibr">258</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Hyrtios</italic> sp. sesterterpene (<bold>242</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">TDP-43 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.4 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">TDP-43 to DNA binding inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">ITA, PYF</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B259-marinedrugs-18-00005" ref-type="bibr">259</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">irciniastatin A (<bold>243</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">TNF-α receptor 1 ectodomain shedding</td><td align="left" valign="middle" rowspan="1" colspan="1">10 nM *</td><td align="left" valign="middle" rowspan="1" colspan="1">ERK activation induced</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B260-marinedrugs-18-00005" ref-type="bibr">260</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">iejimalide C (<bold>244</bold>)/ascidian</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">V-ATPase inhibitor</td><td align="left" valign="middle" rowspan="1" colspan="1">0.12 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Bafilomycin site binding </td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B261-marinedrugs-18-00005" ref-type="bibr">261</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Laurencia</italic> sp. indole (<bold>245</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Aryl hydrocarbon receptor agonist</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">DNA binding stimulation and CYP1A1 induction</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B262-marinedrugs-18-00005" ref-type="bibr">262</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">neopetroside A (<bold>246</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Cardiomyocyte mitochondrial upregulation </td><td align="left" valign="middle" rowspan="1" colspan="1">10 µM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Increased ATP levels and O<sub>2</sub> consumption</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B263-marinedrugs-18-00005" ref-type="bibr">263</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">Phlorofucofuroeckol-A (<bold>10</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Lipid accumulation inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">18 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Decreased PPARγ expression</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B264-marinedrugs-18-00005" ref-type="bibr">264</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">polytheonamide B (<bold>247</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">One-ion pore channel permeation determined</td><td align="left" valign="middle" rowspan="1" colspan="1">NA</td><td align="left" valign="middle" rowspan="1" colspan="1">Two ion binding sites defined, but second ion excluded</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B265-marinedrugs-18-00005" ref-type="bibr">265</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">siphonaxanthin (<bold>248</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Adipogenesis inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 µM </td><td align="left" valign="middle" rowspan="1" colspan="1">Transcription factor inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B266-marinedrugs-18-00005" ref-type="bibr">266</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">spiromastixones J and L (<bold>57</bold>, <bold>249</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Cholesterol uptake inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">PPARγ upregulation</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B267-marinedrugs-18-00005" ref-type="bibr">267</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">thalassospiramide C (<bold>250</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HCAN1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.4 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Binding to Cys115 residue</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B268-marinedrugs-18-00005" ref-type="bibr">268</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">xyloketal B (<bold>251</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Atherosclerotic plaque attenuation</td><td align="left" valign="middle" rowspan="1" colspan="1">14 mg/kg ***</td><td align="left" valign="middle" rowspan="1" colspan="1">Increased eNOS activity</td><td align="left" valign="middle" rowspan="1" colspan="1">CAN, CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B269-marinedrugs-18-00005" ref-type="bibr">269</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">xyloketal B (<bold>251</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">P450 3a activity and expression regulation</td><td align="left" valign="middle" rowspan="1" colspan="1">14 mg/kg ***</td><td align="left" valign="middle" rowspan="1" colspan="1">Active site binding determined by docking studies</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B270-marinedrugs-18-00005" ref-type="bibr">270</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>X. testudinaria</italic> lipid (<bold>252</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Pancreatic lipase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.11 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Triglyceride level decrease in vivo</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, ITA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B271-marinedrugs-18-00005" ref-type="bibr">271</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">acuminolide A (<bold>253</bold>)/dinoflagellate</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Stimulation of actomyosin ATPase</td><td align="left" valign="middle" rowspan="1" colspan="1">1 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B272-marinedrugs-18-00005" ref-type="bibr">272</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">ahpatinin Ac (<bold>254</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Pepsin inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">11 nM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B273-marinedrugs-18-00005" ref-type="bibr">273</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">alternariol derivatives (<bold>255–257</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Shikimate <sup>h</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">HCV protease inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">12–52 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY, SAU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B136-marinedrugs-18-00005" ref-type="bibr">136</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">apliamide D (<bold>258</bold>)/ascidian</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Na<sup>+</sup>/K<sup>+</sup>-ATPase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.2 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B274-marinedrugs-18-00005" ref-type="bibr">274</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">austalides 4 and 9 (<bold>259</bold>, <bold>260</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Endo</italic>-1,3-<italic>β</italic>-D-glucanase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.01 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B275-marinedrugs-18-00005" ref-type="bibr">275</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">axinelline A (<bold>261</bold>)/bacterium</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">COX-2 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.8 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B276-marinedrugs-18-00005" ref-type="bibr">276</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">brevisulcatic acid-4 (<bold>262</bold>)/dinoflagellate</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Activation of sodium channels</td><td align="left" valign="middle" rowspan="1" colspan="1">20 ng/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN, NZL</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B277-marinedrugs-18-00005" ref-type="bibr">277</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">4′,5′-dehydrodiodictyonema (<bold>263</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.3 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B278-marinedrugs-18-00005" ref-type="bibr">278</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>D. metachromia</italic> sesquiterpenes (<bold>264–266</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Multiple kinases inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.97–4.8 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, NLD, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B279-marinedrugs-18-00005" ref-type="bibr">279</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">didemnaketals D and E (<bold>267</bold>, <bold>268</bold>)/ascidian</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Multiple kinases inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">EGY</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B280-marinedrugs-18-00005" ref-type="bibr">280</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">dysiquinol D (<bold>269</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">NF-κB inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.81 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B281-marinedrugs-18-00005" ref-type="bibr">281</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">fucoxanthin (<bold>134</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Hydroxyl radical-scavenging</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B282-marinedrugs-18-00005" ref-type="bibr">282</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">halenaquinol sulfate (<bold>270</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">CDK9 and DYRK1A inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.5–0.61 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">FRA, NZL</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B283-marinedrugs-18-00005" ref-type="bibr">283</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">1-hydroxyethylhalenaquinone (<bold>271</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Proteasome-chymotrypsin-like activity inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.19 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IDN, JPN, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B284-marinedrugs-18-00005" ref-type="bibr">284</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">hymenialdisine derivatives (<bold>272–274</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">P<italic>f</italic>GSK-3 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.07–0.2 μM </td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">DEU, EGY, FRA, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B285-marinedrugs-18-00005" ref-type="bibr">285</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">hymenialdisine (<bold>275</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">CK1, CDK5, GSK3β inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.03–0.16 μM</td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B286-marinedrugs-18-00005" ref-type="bibr">286</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">hyattellactone A (<bold>276</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1"> Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">7.45 μM</td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IDN, JPN </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B287-marinedrugs-18-00005" ref-type="bibr">287</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>H. lachne</italic> sesterterpenoid (<bold>277</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1"> Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5.2 μM</td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B288-marinedrugs-18-00005" ref-type="bibr">288</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">ianthelliformisamines A–C (<bold>278</bold>, <bold>7</bold>, <bold>8</bold>)/ sponge</td><td align="left" valign="middle" rowspan="1" colspan="1"> Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Carbonic anhydrase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">0.2–0.85 μM **</td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUS, ITA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B289-marinedrugs-18-00005" ref-type="bibr">289</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">incisterols A5 and A6 (<bold>279</bold>, <bold>280</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1"> Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PXR agonists</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">ITA </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B290-marinedrugs-18-00005" ref-type="bibr">290</xref>] </td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. crassum</italic> cembranoid (<bold>281</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1"> Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PPAR transcription activation</td><td align="left" valign="middle" rowspan="1" colspan="1">2.07 μM</td><td align="left" valign="middle" rowspan="1" colspan="1"> Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">VNM</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B291-marinedrugs-18-00005" ref-type="bibr">291</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>L. okamurai</italic> terpenoid (<bold>282</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4.9 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B292-marinedrugs-18-00005" ref-type="bibr">292</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">malonganenone L (<bold>283</bold>)/sea whip</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PDE4D inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8.5 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B293-marinedrugs-18-00005" ref-type="bibr">293</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">punctaporonin K (<bold>284</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Lipid-lowering effect </td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B294-marinedrugs-18-00005" ref-type="bibr">294</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">psychrophilin G (<bold>285</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Peptide <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Lipid-lowering effect</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B295-marinedrugs-18-00005" ref-type="bibr">295</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">racemosin (<bold>286</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5.9 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B296-marinedrugs-18-00005" ref-type="bibr">296</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">sarcoehrendin B (<bold>287</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PDE4 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">3.7 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B297-marinedrugs-18-00005" ref-type="bibr">297</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">sarsolilide A (<bold>288</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">6.8 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, HUN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B298-marinedrugs-18-00005" ref-type="bibr">298</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>Stachybotry</italic> sp. xanthone (<bold>289</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">COX-2 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">8.9 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B299-marinedrugs-18-00005" ref-type="bibr">299</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>S. thunbergii</italic> alkapolyene (<bold>290</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Soybean LOX inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">5 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN, S. KOR</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B300-marinedrugs-18-00005" ref-type="bibr">300</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">shinorine (<bold>291</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1"><italic>C. histolyticum</italic> collagenase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">104 µM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">AUT</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B301-marinedrugs-18-00005" ref-type="bibr">301</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">sinularone D (<bold>292</bold>)/soft coral</td><td align="left" valign="middle" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">NF-κB inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μg/mL *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B302-marinedrugs-18-00005" ref-type="bibr">302</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1"><italic>N</italic>-(2-benzenepropanoic acid) stachybotrylactam (<bold>293</bold>)/fungus</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Triglyceride and cholesterol inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN, DEU </td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B303-marinedrugs-18-00005" ref-type="bibr">303</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">strongylophorine-13/-14 (<bold>294</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Hu proteasome 20S inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.1 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B304-marinedrugs-18-00005" ref-type="bibr">304</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">swinhoeisterol A (<bold>295</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">(h)P300 acetyltransferase inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.7 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">ITA, CHN, USA</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B305-marinedrugs-18-00005" ref-type="bibr">305</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">thunberol (<bold>296</bold>)/alga</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">PTP1B inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">2.24 μg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CHN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B306-marinedrugs-18-00005" ref-type="bibr">306</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">xestosaprol O (<bold>297</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Terpenoid <sup>f</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">IDO1 inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 μM</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">CAN, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B307-marinedrugs-18-00005" ref-type="bibr">307</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">urupocidin A (<bold>298</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">iNOS expression induction</td><td align="left" valign="middle" rowspan="1" colspan="1">10 μM *</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">RUS, TWN</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B308-marinedrugs-18-00005" ref-type="bibr">308</xref>]</td></tr><tr><td align="left" valign="middle" rowspan="1" colspan="1">variabine B (<bold>299</bold>)/sponge</td><td align="left" valign="middle" rowspan="1" colspan="1">Alkaloid <sup>g</sup></td><td align="left" valign="middle" rowspan="1" colspan="1">Proteasome-chymotrypsin-like activity inhibition</td><td align="left" valign="middle" rowspan="1" colspan="1">4 µg/mL</td><td align="left" valign="middle" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" rowspan="1" colspan="1">IDN, JPN, NLD</td><td align="left" valign="middle" rowspan="1" colspan="1">[<xref rid="B309-marinedrugs-18-00005" ref-type="bibr">309</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">yoshinone A (<bold>300</bold>)/cyanobacterium</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Polyketide <sup>e</sup></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Triglyceride inhibition</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.4 μM</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Undetermined</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">JPN</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B310-marinedrugs-18-00005" ref-type="bibr">310</xref>]</td></tr></tbody></table><table-wrap-foot><fn><p><sup>a</sup><bold>Organism</bold>, <italic>Kingdom Animalia</italic>: ascidian (Phylum Chordata), soft corals, sea whips, and sea anemone (Phylum Cnidaria), dinoflagellates (Phylum Dinoflagellata), sea urchin (Phylum Echinodermata), sponge (Phylum Porifera); <italic>Kingdom Fungi</italic>: fungus; <italic>Kingdom Plantae:</italic> alga; <italic>Kingdom Monera</italic>: bacterium; <sup>b</sup><bold>IC<sub>50</sub></bold>: concentration of a compound required for 50% inhibition in vitro; *: estimated IC<sub>50</sub>; **: Ki; *** in vivo study; <sup>c</sup><bold>MMOA</bold>: molecular mechanism of action; <sup>d</sup><bold>Country:</bold> AUS: Australia; AUT: Austria; BEL: Belgium; BRA: Brazil; CAN: Canada; CHE: Switzerland; CHN: China; DEU: Germany; EGY: Egypt; FRA: France; ESP: Spain; GBR: United Kingdom; HUN: Hungary; IDN: Indonesia; ISR: Israel; ITA: Italy; JPN: Japan; NLD: The Netherlands; NZL: New Zealand; PYF: French Polynesia; RUS: Russian Federation; SAU: Saudi Arabia; S. KOR: South Korea; TWN: Taiwan; VNM: Vietnam; <bold>Chemistry:</bold><sup>e</sup> Polyketide; <sup>f</sup> Terpene; <sup>g</sup> Nitrogen-containing compound; <sup>h</sup> shikimate; <bold>Abbreviations:</bold> ACAT: acyl-CoA:cholesterol acyl-transferase; CB: cannabinoid; CDK: cyclin-dependent kinase; COX-2: cyclooxygenase 2; CK1: casein kinase 1; CypD: cyclophilin D; DDYRK: dual-specificity, tyrosine phosphorylation regulated kinase; DPHC: diphlorethohydroxycarmalol; eNOS: endothelial nitric oxide synthase; ERK: extracellular signal-regulated kinase; GAPDH: D-glyceraldehyde-3-phosphate dehydrogenase; GSK3β: glycogen synthase kinase 3; HASMC: human aortic smooth muscle cells; HCAN1: human calpain 1 protease; HCV: hepatitis C virus; hENO1: human alpha-enolase; hu: human; HO-1: hemeoxygenase-1; IDO1: indoleamine 2, 3 dioxygenase; IL: interleukin; iNOS: inducible nitric oxide synthase; LOX: lipoxygenase; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NO: nitric oxide; mPTP: mitochondrial permeability transition pore; PDGF: platelet-derived growth factor; PDE4: phosphodiesterase 4; PPAR: peroxisome proliferator-activated receptor; PTP1B: protein tyrosine phosphatase 1B; PXR: pregnane-X-receptor; ROS: reactive oxygen species; SERCA2A: SR Ca<sup>2+</sup> ATPase 2A; TLR5: Toll-like receptor 5; TDP-43: trans-activation response DNA-binding protein of 43 kDa; UVB: ultraviolet B; V-ATPase: vacuolar-type H<sup>+</sup>-ATPase; VEGF: vascular endothelial growth factor.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action
}}
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