Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology
Identifieur interne : 000A02 ( Pmc/Curation ); précédent : 000A01; suivant : 000A03Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology
Auteurs : Sidharth Sonthalia ; Parul AggarwalSource :
- Indian Dermatology Online Journal [ 2229-5178 ] ; 2019.
Abstract
Tofacitinib, an oral Janus kinase inhibitor (Jakinib), is an emerging treatment modality whose well-established efficacy in systemic inflammatory diseases is now being actively explored for cutaneous disorders (arising due to the patient's dysimmune responses) that are not responding to and/or sustaining intolerable adverse effects with the classical immunosuppressives and other targeted therapies such as the biologics. The most common dermatoses for which oral as well as topical Jakinibs such as tofacitinib have been evaluated and are being used albeit as an off-label indication include psoriasis, psoriatic arthritis, alopecia areata, vitiligo, and atopic dermatitis. This article provides a succinct review on the current status of oral tofacitinib in dermatology through literature search of PubMed database and stresses on the need for further evidence generation to define the drug's place in the therapeutic arsenal of dysimmune cutaneous disorders.
Url:
DOI: 10.4103/idoj.IDOJ_474_18
PubMed: 31544068
PubMed Central: 6743407
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<front><div type="abstract" xml:lang="en"><p>Tofacitinib, an oral Janus kinase inhibitor (Jakinib), is an emerging treatment modality whose well-established efficacy in systemic inflammatory diseases is now being actively explored for cutaneous disorders (arising due to the patient's dysimmune responses) that are not responding to and/or sustaining intolerable adverse effects with the classical immunosuppressives and other targeted therapies such as the biologics. The most common dermatoses for which oral as well as topical Jakinibs such as tofacitinib have been evaluated and are being used albeit as an off-label indication include psoriasis, psoriatic arthritis, alopecia areata, vitiligo, and atopic dermatitis. This article provides a succinct review on the current status of oral tofacitinib in dermatology through literature search of PubMed database and stresses on the need for further evidence generation to define the drug's place in the therapeutic arsenal of dysimmune cutaneous disorders.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Indian Dermatol Online J</journal-id>
<journal-id journal-id-type="iso-abbrev">Indian Dermatol Online J</journal-id>
<journal-id journal-id-type="publisher-id">IDOJ</journal-id>
<journal-title-group><journal-title>Indian Dermatology Online Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">2229-5178</issn>
<issn pub-type="epub">2249-5673</issn>
<publisher><publisher-name>Wolters Kluwer - Medknow</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31544068</article-id>
<article-id pub-id-type="pmc">6743407</article-id>
<article-id pub-id-type="publisher-id">IDOJ-10-503</article-id>
<article-id pub-id-type="doi">10.4103/idoj.IDOJ_474_18</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sonthalia</surname>
<given-names>Sidharth</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aggarwal</surname>
<given-names>Parul</given-names>
</name>
<xref ref-type="aff" rid="aff2">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
</contrib-group>
<aff id="aff1"><italic>Medical Director and Senior Consultant Dermatologist, Department of Dermatology and Dermatosurgery, Skinnocence: The Skin Clinic and Research Center, Gurugram, Haryana, India</italic>
</aff>
<aff id="aff2"><label>1</label>
<italic>Consultant Dermatologist, Department of Dermatology and STD, Skinalive Clinic, New Delhi, India</italic>
</aff>
<author-notes><corresp id="cor1"><italic><bold>Address for correspondence: </bold>
Dr. Parul Aggarwal, 1775, Sector 10/A, Gurugram - 122 001, Haryana, India. E-mail: <email xlink:href="parul2909@gmail.com">parul2909@gmail.com</email>
</italic>
</corresp>
</author-notes>
<pub-date pub-type="collection"><season>Sep-Oct</season>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>8</month>
<year>2019</year>
</pub-date>
<volume>10</volume>
<issue>5</issue>
<fpage>503</fpage>
<lpage>518</lpage>
<history><date date-type="received"><month>12</month>
<year>2018</year>
</date>
<date date-type="accepted"><month>3</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2019 Indian Dermatology Online Journal</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0"><license-p>This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.</license-p>
</license>
</permissions>
<abstract><p>Tofacitinib, an oral Janus kinase inhibitor (Jakinib), is an emerging treatment modality whose well-established efficacy in systemic inflammatory diseases is now being actively explored for cutaneous disorders (arising due to the patient's dysimmune responses) that are not responding to and/or sustaining intolerable adverse effects with the classical immunosuppressives and other targeted therapies such as the biologics. The most common dermatoses for which oral as well as topical Jakinibs such as tofacitinib have been evaluated and are being used albeit as an off-label indication include psoriasis, psoriatic arthritis, alopecia areata, vitiligo, and atopic dermatitis. This article provides a succinct review on the current status of oral tofacitinib in dermatology through literature search of PubMed database and stresses on the need for further evidence generation to define the drug's place in the therapeutic arsenal of dysimmune cutaneous disorders.</p>
</abstract>
<kwd-group><kwd><italic>Alopecia areata</italic>
</kwd>
<kwd><italic>atopic dermatitis</italic>
</kwd>
<kwd><italic>Jakinib</italic>
</kwd>
<kwd><italic>Janus kinase inhibitors</italic>
</kwd>
<kwd><italic>psoriasis</italic>
</kwd>
<kwd><italic>psoriatic arthritis</italic>
</kwd>
<kwd><italic>tofacitinib</italic>
</kwd>
<kwd><italic>vitiligo</italic>
</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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