Innate Immune Cells' Contribution to Systemic Lupus Erythematosus
Identifieur interne : 000965 ( Pmc/Curation ); précédent : 000964; suivant : 000966Innate Immune Cells' Contribution to Systemic Lupus Erythematosus
Auteurs : Andrés A. Herrada [Chili] ; Noelia Escobedo [Chili] ; Mirentxu Iruretagoyena [Chili] ; Rodrigo A. Valenzuela [Chili] ; Paula I. Burgos [Chili] ; Loreto Cuitino [Chili] ; Carolina Llanos [Chili]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2019.
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therapies in SLE.
Url:
DOI: 10.3389/fimmu.2019.00772
PubMed: 31037070
PubMed Central: 6476281
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Innate Immune Cells' Contribution to Systemic Lupus Erythematosus</title>
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<front><div type="abstract" xml:lang="en"><p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therapies in SLE.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Immunol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Immunol.</journal-id>
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<issn pub-type="epub">1664-3224</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
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<article-meta><article-id pub-id-type="pmid">31037070</article-id>
<article-id pub-id-type="pmc">6476281</article-id>
<article-id pub-id-type="doi">10.3389/fimmu.2019.00772</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Immunology</subject>
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<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/675122/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Iruretagoyena</surname>
<given-names>Mirentxu</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/228869/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Valenzuela</surname>
<given-names>Rodrigo A.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/710809/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Burgos</surname>
<given-names>Paula I.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/275642/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Cuitino</surname>
<given-names>Loreto</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/675611/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Llanos</surname>
<given-names>Carolina</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="c002"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/483224/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Lymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile</institution>
,<addr-line>Talca</addr-line>
,<country>Chile</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Departamento de Inmunología Clínica y Reumatología, Escuela de Medicina, Pontificia Universidad Católica de Chile</institution>
,<addr-line>Santiago</addr-line>
,<country>Chile</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Laboratorio de Enfermedades Autoinmunes Oculares y Sistémicas, Departamento de Oftalmología, Facultad de Medicina, Universidad de Chile</institution>
,<addr-line>Santiago</addr-line>
,<country>Chile</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Departamento de Ciencias Químicas y Biológicas, Facultad de Salud, Universidad Bernardo O'Higgins</institution>
,<addr-line>Santiago</addr-line>
,<country>Chile</country>
</aff>
<aff id="aff5"><sup>5</sup>
<institution>Servicio de Oftalmología, Hospital Clínico Universidad de Chile</institution>
,<addr-line>Santiago</addr-line>
,<country>Chile</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: J. Michelle Kahlenberg, University of Michigan, United States</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Xin M. Luo, Virginia Tech, United States; Julia Weinmann-Menke, Johannes Gutenberg University Mainz, Germany</p>
</fn>
<corresp id="c001">*Correspondence: Loreto Cuitino <email>cuitinole@gmail.com</email>
</corresp>
<corresp id="c002">Carolina Llanos <email>cllanos@med.puc.cl</email>
</corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>15</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>10</volume>
<elocation-id>772</elocation-id>
<history><date date-type="received"><day>22</day>
<month>1</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>25</day>
<month>3</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2019 Herrada, Escobedo, Iruretagoyena, Valenzuela, Burgos, Cuitino and Llanos.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Herrada, Escobedo, Iruretagoyena, Valenzuela, Burgos, Cuitino and Llanos</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therapies in SLE.</p>
</abstract>
<kwd-group><kwd>lupus (SLE)</kwd>
<kwd>innate immunity</kwd>
<kwd>dendritic cells</kwd>
<kwd>macrophage-cell</kwd>
<kwd>innate lymphoid cell</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">Comisión Nacional de Investigación Científica y Tecnológica<named-content content-type="fundref-id">10.13039/501100002848</named-content>
</funding-source>
</award-group>
</funding-group>
<counts><fig-count count="1"></fig-count>
<table-count count="1"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="103"></ref-count>
<page-count count="9"></page-count>
<word-count count="7085"></word-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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