Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer
Identifieur interne : 000741 ( Pmc/Curation ); précédent : 000740; suivant : 000742Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer
Auteurs : Yuanyuan Tian [République populaire de Chine] ; Wenjing Song [République populaire de Chine] ; Dan Li [République populaire de Chine] ; Lu Cai [États-Unis] ; Yuguang Zhao [République populaire de Chine]Source :
- OncoTargets and therapy [ 1178-6930 ] ; 2019.
Abstract
Resveratrol, as a natural product compound, has been recently attracted much attention for its potent effects on cancer. Cancer is a serious disease threatening human survival and social development. Autophagy is a cellular pathway to realize the metabolic needs of the cell itself and the renewal of some organelles and plays opposing, context-dependent role in tumorigenesis. So the regulation of autophagy is of great significance in the treatment of cancer. p62, as an autophagy adaptor protein, is a preferred target for autophagy and is constantly controlled by constitutive autophagy. As a tumor-suppression mechanism, autophagy deficiency is common in tumors, which results in aberrant accumulation of p62 and activates p62-regulated pathways, such as activation of mTOR in nutrient sensing, and the activation of the Keap1-Nrf2 pathway for antioxidant stress, which are associated with cancer development. In this review, we emphasize that resveratrol can induce autophagy in the treatment of cancer and accelerates the degradation of p62, and then, the mTOR activation is blocked and Nrf2 activation is suppressed. As a result, the multidrug resistance of cancer cells can be reversed by resveratrol.
Url:
DOI: 10.2147/OTT.S213043
PubMed: 31802896
PubMed Central: 6802539
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Resveratrol, as a natural product compound, has been recently attracted much attention for its potent effects on cancer. Cancer is a serious disease threatening human survival and social development. Autophagy is a cellular pathway to realize the metabolic needs of the cell itself and the renewal of some organelles and plays opposing, context-dependent role in tumorigenesis. So the regulation of autophagy is of great significance in the treatment of cancer. p62, as an autophagy adaptor protein, is a preferred target for autophagy and is constantly controlled by constitutive autophagy. As a tumor-suppression mechanism, autophagy deficiency is common in tumors, which results in aberrant accumulation of p62 and activates p62-regulated pathways, such as activation of mTOR in nutrient sensing, and the activation of the Keap1-Nrf2 pathway for antioxidant stress, which are associated with cancer development. In this review, we emphasize that resveratrol can induce autophagy in the treatment of cancer and accelerates the degradation of p62, and then, the mTOR activation is blocked and Nrf2 activation is suppressed. As a result, the multidrug resistance of cancer cells can be reversed by resveratrol.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Onco Targets Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">Onco Targets Ther</journal-id>
<journal-id journal-id-type="publisher-id">OTT</journal-id>
<journal-id journal-id-type="pmc">ott</journal-id>
<journal-title-group><journal-title>OncoTargets and therapy</journal-title>
</journal-title-group>
<issn pub-type="epub">1178-6930</issn>
<publisher><publisher-name>Dove</publisher-name>
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<article-meta><article-id pub-id-type="pmid">31802896</article-id>
<article-id pub-id-type="pmc">6802539</article-id>
<article-id pub-id-type="publisher-id">213043</article-id>
<article-id pub-id-type="doi">10.2147/OTT.S213043</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer</article-title>
<alt-title alt-title-type="running-authors">Tian et al</alt-title>
<alt-title alt-title-type="running-title">Tian et al</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tian</surname>
<given-names>Yuanyuan</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Song</surname>
<given-names>Wenjing</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Dan</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cai</surname>
<given-names>Lu</given-names>
</name>
<xref ref-type="aff" rid="AFF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Yuguang</given-names>
</name>
<xref ref-type="corresp" rid="AN0001"></xref>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<aff id="AFF0001"><label>1</label>
<institution>Cancer Center, the First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<addr-line>Jilin</addr-line>
<addr-line>130021</addr-line>
,<country>People’s Republic of China</country>
</aff>
<aff id="AFF0002"><label>2</label>
<institution>Departments of Pediatrics, Radiation Oncology, Pharmacology and Toxicology, University of Louisville</institution>
,<addr-line>Louisville</addr-line>
,<addr-line>KY</addr-line>
<addr-line>40292</addr-line>
,<country>USA</country>
</aff>
</contrib-group>
<author-notes><corresp id="AN0001">Correspondence: Yuguang Zhao <institution>Cancer Center, the First Hospital of Jilin University</institution>
, <addr-line>Changchun</addr-line>
, <addr-line>Jilin</addr-line>
<addr-line>130021</addr-line>
, <country>People’s Republic of China</country>
<phone>Tel +8643115804303822</phone>
Email zhaoyuguang@jlu.edu.cn</corresp>
</author-notes>
<pub-date pub-type="epub"><day>17</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>12</volume>
<fpage>8601</fpage>
<lpage>8609</lpage>
<history><date date-type="received"><day>22</day>
<month>4</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>23</day>
<month>9</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 Tian et al.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Tian et al.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
).</license-p>
</license>
</permissions>
<abstract><title>Abstract</title>
<p>Resveratrol, as a natural product compound, has been recently attracted much attention for its potent effects on cancer. Cancer is a serious disease threatening human survival and social development. Autophagy is a cellular pathway to realize the metabolic needs of the cell itself and the renewal of some organelles and plays opposing, context-dependent role in tumorigenesis. So the regulation of autophagy is of great significance in the treatment of cancer. p62, as an autophagy adaptor protein, is a preferred target for autophagy and is constantly controlled by constitutive autophagy. As a tumor-suppression mechanism, autophagy deficiency is common in tumors, which results in aberrant accumulation of p62 and activates p62-regulated pathways, such as activation of mTOR in nutrient sensing, and the activation of the Keap1-Nrf2 pathway for antioxidant stress, which are associated with cancer development. In this review, we emphasize that resveratrol can induce autophagy in the treatment of cancer and accelerates the degradation of p62, and then, the mTOR activation is blocked and Nrf2 activation is suppressed. As a result, the multidrug resistance of cancer cells can be reversed by resveratrol.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>resveratrol</kwd>
<kwd>cancer</kwd>
<kwd>autophagy</kwd>
<kwd>p62</kwd>
<kwd>mTOR</kwd>
<kwd>Nrf2</kwd>
</kwd-group>
<counts><fig-count count="1"></fig-count>
<table-count count="1"></table-count>
<ref-count count="84"></ref-count>
<page-count count="9"></page-count>
</counts>
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</front>
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