Serum uric acid is associated with damage in patients with systemic lupus erythematosus
Identifieur interne : 000690 ( Pmc/Curation ); précédent : 000689; suivant : 000691Serum uric acid is associated with damage in patients with systemic lupus erythematosus
Auteurs : Claudia Elera-Fitzcarrald [Pérou] ; Cristina Reátegui-Sokolova [Pérou] ; Rocio Violeta Gamboa-Cardenas [Pérou] ; Mariela Medina [Pérou] ; Francisco Zevallos [Pérou] ; Victor Román Pimentel-Quiroz [Pérou] ; Jorge Mariano Cucho-Venegas [Pérou] ; José Alfaro-Lozano [Pérou] ; Zoila Rodriguez-Bellido [Pérou] ; Cesar Augusto Pastor-Asurza [Pérou] ; Risto Alfredo Perich-Campos [Pérou] ; Graciela S. Alarc N [États-Unis, Pérou] ; Manuel Francisco Ugarte-Gil [Pérou]Source :
- Lupus Science & Medicine [ 2053-8790 ] ; 2020.
Abstract
Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.
To determine whether serum uric acid levels are associated with new damage in patients with SLE.
This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.
We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).
Higher serum uric acid levels are associated with global damage in patients with SLE.
Url:
DOI: 10.1136/lupus-2019-000366
PubMed: 32153795
PubMed Central: 7046960
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Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perich Campos, Risto Alfredo" sort="Perich Campos, Risto Alfredo" uniqKey="Perich Campos R" first="Risto Alfredo" last="Perich-Campos">Risto Alfredo Perich-Campos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. Alarc N</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="department">Department of Medicine, Division of Clinical Immunology and Rheumatology</institution>,<institution>School of Medicine, The University of Alabama</institution>,<addr-line content-type="city">Birmingham</addr-line>,<addr-line content-type="state">Alabama</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="department">Department of Medicine</institution>,<institution>Universidad Peruana Cayetana Heredia</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ugarte Gil, Manuel Francisco" sort="Ugarte Gil, Manuel Francisco" uniqKey="Ugarte Gil M" first="Manuel Francisco" last="Ugarte-Gil">Manuel Francisco Ugarte-Gil</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">School of Medicine</institution>,<institution>Universidad Científica del Sur</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32153795</idno><idno type="pmc">7046960</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046960</idno><idno type="RBID">PMC:7046960</idno><idno type="doi">10.1136/lupus-2019-000366</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000690</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000690</idno><idno type="wicri:Area/Pmc/Curation">000690</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000690</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serum uric acid is associated with damage in patients with systemic lupus erythematosus</title><author><name sortKey="Elera Fitzcarrald, Claudia" sort="Elera Fitzcarrald, Claudia" uniqKey="Elera Fitzcarrald C" first="Claudia" last="Elera-Fitzcarrald">Claudia Elera-Fitzcarrald</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">School of Medicine</institution>,<institution>Universidad Científica del Sur</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reategui Sokolova, Cristina" sort="Reategui Sokolova, Cristina" uniqKey="Reategui Sokolova C" first="Cristina" last="Reátegui-Sokolova">Cristina Reátegui-Sokolova</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud</institution>,<institution>Universidad San Ignancio de Loyola</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gamboa Cardenas, Rocio Violeta" sort="Gamboa Cardenas, Rocio Violeta" uniqKey="Gamboa Cardenas R" first="Rocio Violeta" last="Gamboa-Cardenas">Rocio Violeta Gamboa-Cardenas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Medina, Mariela" sort="Medina, Mariela" uniqKey="Medina M" first="Mariela" last="Medina">Mariela Medina</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zevallos, Francisco" sort="Zevallos, Francisco" uniqKey="Zevallos F" first="Francisco" last="Zevallos">Francisco Zevallos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pimentel Quiroz, Victor Roman" sort="Pimentel Quiroz, Victor Roman" uniqKey="Pimentel Quiroz V" first="Victor Román" last="Pimentel-Quiroz">Victor Román Pimentel-Quiroz</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cucho Venegas, Jorge Mariano" sort="Cucho Venegas, Jorge Mariano" uniqKey="Cucho Venegas J" first="Jorge Mariano" last="Cucho-Venegas">Jorge Mariano Cucho-Venegas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alfaro Lozano, Jose" sort="Alfaro Lozano, Jose" uniqKey="Alfaro Lozano J" first="José" last="Alfaro-Lozano">José Alfaro-Lozano</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Bellido, Zoila" sort="Rodriguez Bellido, Zoila" uniqKey="Rodriguez Bellido Z" first="Zoila" last="Rodriguez-Bellido">Zoila Rodriguez-Bellido</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pastor Asurza, Cesar Augusto" sort="Pastor Asurza, Cesar Augusto" uniqKey="Pastor Asurza C" first="Cesar Augusto" last="Pastor-Asurza">Cesar Augusto Pastor-Asurza</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perich Campos, Risto Alfredo" sort="Perich Campos, Risto Alfredo" uniqKey="Perich Campos R" first="Risto Alfredo" last="Perich-Campos">Risto Alfredo Perich-Campos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. Alarc N</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="department">Department of Medicine, Division of Clinical Immunology and Rheumatology</institution>,<institution>School of Medicine, The University of Alabama</institution>,<addr-line content-type="city">Birmingham</addr-line>,<addr-line content-type="state">Alabama</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="department">Department of Medicine</institution>,<institution>Universidad Peruana Cayetana Heredia</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ugarte Gil, Manuel Francisco" sort="Ugarte Gil, Manuel Francisco" uniqKey="Ugarte Gil M" first="Manuel Francisco" last="Ugarte-Gil">Manuel Francisco Ugarte-Gil</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">School of Medicine</institution>,<institution>Universidad Científica del Sur</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lupus Science & Medicine</title><idno type="eISSN">2053-8790</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.</p></sec><sec><title>Objective</title><p>To determine whether serum uric acid levels are associated with new damage in patients with SLE.</p></sec><sec><title>Methods</title><p>This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.</p></sec><sec><title>Results</title><p>We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).</p></sec><sec><title>Conclusion</title><p>Higher serum uric acid levels are associated with global damage in patients with SLE.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Desideri, G" uniqKey="Desideri G">G Desideri</name></author><author><name sortKey="Castaldo, G" uniqKey="Castaldo G">G Castaldo</name></author><author><name sortKey="Lombardi, A" uniqKey="Lombardi A">A Lombardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trevi O Becerra, A" uniqKey="Trevi O Becerra A">A Treviño-Becerra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stack, Ag" uniqKey="Stack A">AG Stack</name></author><author><name sortKey="Hanley, A" uniqKey="Hanley A">A 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uniqKey="Bruce I">IN Bruce</name></author><author><name sortKey="O Keeffe, Ag" uniqKey="O Keeffe A">AG O'Keeffe</name></author><author><name sortKey="Farewell, V" uniqKey="Farewell V">V Farewell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alarcon, Gs" uniqKey="Alarcon G">GS Alarcon</name></author><author><name sortKey="Mcgwin, G" uniqKey="Mcgwin G">G McGwin</name></author><author><name sortKey="Bertoli, Am" uniqKey="Bertoli A">AM Bertoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaharir, Ss" uniqKey="Shaharir S">SS Shaharir</name></author><author><name sortKey="Ghafor, Aha" uniqKey="Ghafor A">AHA Ghafor</name></author><author><name sortKey="Said, Msm" uniqKey="Said M">MSM Said</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name></author><author><name sortKey="Liang, Y" uniqKey="Liang Y">Y Liang</name></author><author><name sortKey="Xi, W" uniqKey="Xi W">W Xi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ugolini Lopes, Mr" uniqKey="Ugolini Lopes M">MR Ugolini-Lopes</name></author><author><name sortKey="Gavinier, Ss" uniqKey="Gavinier S">SS Gavinier</name></author><author><name sortKey="Leon, E" uniqKey="Leon E">E Leon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sabio, Ja" uniqKey="Sabio J">JA Sabio</name></author><author><name sortKey="Vargas Hitos, Ja" uniqKey="Vargas Hitos J">JA Vargas-Hitos</name></author><author><name sortKey="Mario, J" uniqKey="Mario J">J Mario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K J" uniqKey="Kim K">K-J Kim</name></author><author><name sortKey="Baek, I W" uniqKey="Baek I">I-W Baek</name></author><author><name sortKey="Park, Y J" uniqKey="Park Y">Y-J Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shamsi, Fa" uniqKey="Shamsi F">FA Shamsi</name></author><author><name sortKey="Hadi, Sm" uniqKey="Hadi S">SM Hadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanellis, J" uniqKey="Kanellis J">J Kanellis</name></author><author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name></author><author><name sortKey="Li, Jh" uniqKey="Li J">JH Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ames, Bn" uniqKey="Ames B">BN Ames</name></author><author><name sortKey="Cathcart, R" uniqKey="Cathcart R">R Cathcart</name></author><author><name sortKey="Schwiers, E" uniqKey="Schwiers E">E Schwiers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, Bf" uniqKey="Becker B">BF Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Re, R" uniqKey="Re R">R Re</name></author><author><name sortKey="Pellegrini, N" uniqKey="Pellegrini N">N 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Lupus Sci Med</journal-id><journal-id journal-id-type="iso-abbrev">Lupus Sci Med</journal-id><journal-id journal-id-type="hwp">lupusscimed</journal-id><journal-id journal-id-type="publisher-id">lupus</journal-id><journal-title-group><journal-title>Lupus Science & Medicine</journal-title></journal-title-group><issn pub-type="epub">2053-8790</issn><publisher><publisher-name>BMJ Publishing Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32153795</article-id><article-id pub-id-type="pmc">7046960</article-id><article-id pub-id-type="publisher-id">lupus-2019-000366</article-id><article-id pub-id-type="doi">10.1136/lupus-2019-000366</article-id><article-categories><subj-group subj-group-type="heading"><subject>Epidemiology and Outcomes</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject><subject>2257</subject></subj-group><series-title>Original research</series-title></article-categories><title-group><article-title>Serum uric acid is associated with damage in patients with systemic lupus erythematosus</article-title></title-group><contrib-group><contrib id="author-48988542" contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-7271-2523</contrib-id><name><surname>Elera-Fitzcarrald</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-49233784" contrib-type="author"><name><surname>Reátegui-Sokolova</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib id="author-35676905" contrib-type="author"><name><surname>Gamboa-Cardenas</surname><given-names>Rocio Violeta</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-72918891" contrib-type="author"><name><surname>Medina</surname><given-names>Mariela</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-35676917" contrib-type="author"><name><surname>Zevallos</surname><given-names>Francisco</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-50407697" contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-3638-7054</contrib-id><name><surname>Pimentel-Quiroz</surname><given-names>Victor Román</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-33701670" contrib-type="author"><name><surname>Cucho-Venegas</surname><given-names>Jorge Mariano</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-72918990" contrib-type="author"><name><surname>Alfaro-Lozano</surname><given-names>José</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-35676962" contrib-type="author"><name><surname>Rodriguez-Bellido</surname><given-names>Zoila</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib id="author-34087453" contrib-type="author"><name><surname>Pastor-Asurza</surname><given-names>Cesar Augusto</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib id="author-35676939" contrib-type="author"><name><surname>Perich-Campos</surname><given-names>Risto Alfredo</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib id="author-36184450" contrib-type="author"><name><surname>Alarcón</surname><given-names>Graciela S</given-names></name><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib id="author-34087246" contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-1728-1999</contrib-id><name><surname>Ugarte-Gil</surname><given-names>Manuel Francisco</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution content-type="department">School of Medicine</institution>,<institution>Universidad Científica del Sur</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></aff><aff id="aff2"><label>2</label><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></aff><aff id="aff3"><label>3</label><institution content-type="department">Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud</institution>,<institution>Universidad San Ignancio de Loyola</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></aff><aff id="aff4"><label>4</label><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></aff><aff id="aff5"><label>5</label><institution content-type="department">Department of Medicine, Division of Clinical Immunology and Rheumatology</institution>,<institution>School of Medicine, The University of Alabama</institution>,<addr-line content-type="city">Birmingham</addr-line>,<addr-line content-type="state">Alabama</addr-line>,<country>USA</country></aff><aff id="aff6"><label>6</label><institution content-type="department">Department of Medicine</institution>,<institution>Universidad Peruana Cayetana Heredia</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></aff><author-notes><corresp><label>Correspondence to</label> Dr Claudia Elera-Fitzcarrald; <email>claudiaelerafitz@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>5</day><month>2</month><year>2020</year></pub-date><volume>7</volume><issue>1</issue><elocation-id>e000366</elocation-id><history><date date-type="received"><day>09</day><month>10</month><year>2019</year></date><date date-type="rev-recd"><day>13</day><month>1</month><year>2020</year></date><date date-type="accepted"><day>22</day><month>1</month><year>2020</year></date></history><permissions><copyright-statement>© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access"><ali:license_ref start_date="2020-02-05">http://creativecommons.org/licenses/by-nc/4.0/</ali:license_ref><license-p>This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="lupus-2019-000366.pdf"></self-uri><abstract><sec><title>Introduction</title><p>Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.</p></sec><sec><title>Objective</title><p>To determine whether serum uric acid levels are associated with new damage in patients with SLE.</p></sec><sec><title>Methods</title><p>This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.</p></sec><sec><title>Results</title><p>We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).</p></sec><sec><title>Conclusion</title><p>Higher serum uric acid levels are associated with global damage in patients with SLE.</p></sec></abstract><kwd-group><kwd>systemic lupus erythematosus</kwd><kwd>autoimmune diseases</kwd><kwd>autoimmunity</kwd></kwd-group><funding-group><award-group id="funding-1"><funding-source><institution-wrap><institution>Pan American League of Associations for Rheumatology (PANLAR)</institution></institution-wrap></funding-source><award-id>2015 PANLAR Prize</award-id></award-group><award-group id="funding-2"><funding-source><institution-wrap><institution>Institutional grant from EsSalud</institution></institution-wrap></funding-source><award-id>04-IETSI-ESALUD-2016</award-id><award-id>1483-GCGP-ESSALUD-2013</award-id><award-id>1733-GCGP-ESSALUD-2014</award-id><award-id>2015 Kaelin Prize</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>special-feature</meta-name><meta-value>unlocked</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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