Clinical profile and course of children with postinfectious bronchiolitis obliterans from a tertiary care hospital
Identifieur interne : 000687 ( Pmc/Curation ); précédent : 000686; suivant : 000688Clinical profile and course of children with postinfectious bronchiolitis obliterans from a tertiary care hospital
Auteurs : Krishna Mohan Gulla ; Kana Ram Jat ; Rakesh Lodha ; Sushil K. KabraSource :
- Lung India : Official Organ of Indian Chest Society [ 0970-2113 ] ; 2019.
Abstract
Postinfectious bronchiolitis obliterans (PIBO) is a chronic obstructive lung disease with scanty information in literature on etiology, clinical profile, treatment, and outcome.
The objective of the study is to describe the clinical profile and course of children diagnosed with PIBO.
A chart review of children below 18 years of age diagnosed as PIBO over the past 9 years was carried out. Details of clinical profile, laboratory investigations, imaging, treatment received, and outcome were recorded.
Eight children (boys 4) with PIBO were identified. Median (interquartile range [IQR]) age at the first episode of acute severe bronchiolitis such as illness and diagnosis of PIBO was 15 (6, 23.5) and 30 (16.5, 60) months, respectively, indicating a delay in diagnosis. The most common symptoms were recurrent episodes of cough (100%), fast breathing (100%), wheezing (87.5%), and fever (62.5%). Median (IQR) number of hospitalizations and episodes of antibiotic use prior to diagnosis were 2.5 (2, 5.5) and 2 (2, 4), respectively. Three (37.5%) children received mechanical ventilation during previous hospitalizations. Chest computed tomography revealed mosaic attenuation in 8 (100%), ground-glass opacities in 2 (25%), and bronchial wall thickening in 2 (25%). After diagnosis, 7 received oral steroids, 7 received hydroxychloroquine, 5 received azithromycin, and 2 received azathioprine. The median (IQR) duration of follow-up (
PIBO is still an under-recognized entity with substantial delay in diagnosis and unnecessary use of antibiotics. Clinical course with imaging findings may help to diagnose and manage this entity.
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DOI: 10.4103/lungindia.lungindia_145_19
PubMed: 31898614
PubMed Central: 6961095
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Kabra</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31898614</idno><idno type="pmc">6961095</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961095</idno><idno type="RBID">PMC:6961095</idno><idno type="doi">10.4103/lungindia.lungindia_145_19</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000687</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000687</idno><idno type="wicri:Area/Pmc/Curation">000687</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000687</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical profile and course of children with postinfectious bronchiolitis obliterans from a tertiary care hospital</title><author><name sortKey="Gulla, Krishna Mohan" sort="Gulla, Krishna Mohan" uniqKey="Gulla K" first="Krishna Mohan" last="Gulla">Krishna Mohan Gulla</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jat, Kana Ram" sort="Jat, Kana Ram" uniqKey="Jat K" first="Kana Ram" last="Jat">Kana Ram Jat</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lodha, Rakesh" sort="Lodha, Rakesh" uniqKey="Lodha R" first="Rakesh" last="Lodha">Rakesh Lodha</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kabra, Sushil K" sort="Kabra, Sushil K" uniqKey="Kabra S" first="Sushil K" last="Kabra">Sushil K. Kabra</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Lung India : Official Organ of Indian Chest Society</title><idno type="ISSN">0970-2113</idno><idno type="eISSN">0974-598X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Postinfectious bronchiolitis obliterans (PIBO) is a chronic obstructive lung disease with scanty information in literature on etiology, clinical profile, treatment, and outcome.</p></sec><sec id="st2"><title>Objective:</title><p>The objective of the study is to describe the clinical profile and course of children diagnosed with PIBO.</p></sec><sec id="st3"><title>Methods:</title><p>A chart review of children below 18 years of age diagnosed as PIBO over the past 9 years was carried out. Details of clinical profile, laboratory investigations, imaging, treatment received, and outcome were recorded.</p></sec><sec id="st4"><title>Results:</title><p>Eight children (boys 4) with PIBO were identified. Median (interquartile range [IQR]) age at the first episode of acute severe bronchiolitis such as illness and diagnosis of PIBO was 15 (6, 23.5) and 30 (16.5, 60) months, respectively, indicating a delay in diagnosis. The most common symptoms were recurrent episodes of cough (100%), fast breathing (100%), wheezing (87.5%), and fever (62.5%). Median (IQR) number of hospitalizations and episodes of antibiotic use prior to diagnosis were 2.5 (2, 5.5) and 2 (2, 4), respectively. Three (37.5%) children received mechanical ventilation during previous hospitalizations. Chest computed tomography revealed mosaic attenuation in 8 (100%), ground-glass opacities in 2 (25%), and bronchial wall thickening in 2 (25%). After diagnosis, 7 received oral steroids, 7 received hydroxychloroquine, 5 received azithromycin, and 2 received azathioprine. The median (IQR) duration of follow-up (<italic>n</italic> = 6) was 6 (1.5, 9.5) months. Median (IQR) number of pulmonary exacerbations in follow-up was 2 (1, 5).</p></sec><sec id="st5"><title>Conclusion:</title><p>PIBO is still an under-recognized entity with substantial delay in diagnosis and unnecessary use of antibiotics. Clinical course with imaging findings may help to diagnose and manage this entity.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moonnumakal, Sp" uniqKey="Moonnumakal S">SP Moonnumakal</name></author><author><name sortKey="Fan, Ll" uniqKey="Fan L">LL Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Dh" uniqKey="Chen D">DH Chen</name></author><author><name sortKey="Lin, Yn" uniqKey="Lin Y">YN Lin</name></author><author><name sortKey="Lan, Sl" uniqKey="Lan S">SL Lan</name></author><author><name sortKey="Pan, Xa" uniqKey="Pan X">XA Pan</name></author><author><name sortKey="Zeng, Qs" uniqKey="Zeng Q">QS Zeng</name></author><author><name sortKey="He, Zt" uniqKey="He Z">ZT He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castro Rodriguez, Ja" uniqKey="Castro Rodriguez J">JA Castro-Rodriguez</name></author><author><name sortKey="Daszenies, C" uniqKey="Daszenies C">C Daszenies</name></author><author><name sortKey="Garcia, M" uniqKey="Garcia M">M Garcia</name></author><author><name sortKey="Meyer, R" uniqKey="Meyer R">R Meyer</name></author><author><name sortKey="Gonzales, R" uniqKey="Gonzales R">R Gonzales</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, Gb" uniqKey="Fischer G">GB Fischer</name></author><author><name sortKey="Sarria, Ee" uniqKey="Sarria E">EE Sarria</name></author><author><name sortKey="Mattiello, R" uniqKey="Mattiello R">R Mattiello</name></author><author><name sortKey="Mocelin, Ht" uniqKey="Mocelin H">HT Mocelin</name></author><author><name sortKey="Castro Rodriguez, Ja" uniqKey="Castro Rodriguez J">JA Castro-Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Yn" uniqKey="Li Y">YN Li</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Qiao, Hm" uniqKey="Qiao H">HM Qiao</name></author><author><name sortKey="Cheng, H" uniqKey="Cheng H">H Cheng</name></author><author><name sortKey="Cheng, Hj" uniqKey="Cheng H">HJ Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colom, Aj" uniqKey="Colom A">AJ Colom</name></author><author><name sortKey="Teper, Am" uniqKey="Teper A">AM Teper</name></author><author><name sortKey="Vollmer, Wm" uniqKey="Vollmer W">WM Vollmer</name></author><author><name sortKey="Diette, Gb" uniqKey="Diette G">GB Diette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aguerre, V" uniqKey="Aguerre V">V Aguerre</name></author><author><name sortKey="Casta Os, C" uniqKey="Casta Os C">C Castaños</name></author><author><name sortKey="Pena, Hg" uniqKey="Pena H">HG Pena</name></author><author><name sortKey="Grenoville, M" uniqKey="Grenoville M">M Grenoville</name></author><author><name sortKey="Murtagh, P" uniqKey="Murtagh P">P Murtagh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, Cy" uniqKey="Chiu C">CY Chiu</name></author><author><name sortKey="Wong, Ks" uniqKey="Wong K">KS Wong</name></author><author><name sortKey="Huang, Yc" uniqKey="Huang Y">YC Huang</name></author><author><name sortKey="Lin, Ty" uniqKey="Lin T">TY Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gottlieb, J" uniqKey="Gottlieb J">J Gottlieb</name></author><author><name sortKey="Szangolies, J" uniqKey="Szangolies J">J Szangolies</name></author><author><name sortKey="Koehnlein, T" uniqKey="Koehnlein T">T Koehnlein</name></author><author><name sortKey="Golpon, H" uniqKey="Golpon H">H Golpon</name></author><author><name sortKey="Simon, A" uniqKey="Simon A">A Simon</name></author><author><name sortKey="Welte, T" uniqKey="Welte T">T Welte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vos, R" uniqKey="Vos R">R Vos</name></author><author><name sortKey="Vanaudenaerde, Bm" uniqKey="Vanaudenaerde B">BM Vanaudenaerde</name></author><author><name sortKey="Ottevaere, A" uniqKey="Ottevaere A">A Ottevaere</name></author><author><name sortKey="Verleden, Se" uniqKey="Verleden S">SE Verleden</name></author><author><name sortKey="De Vleeschauwer, Si" uniqKey="De Vleeschauwer S">SI De Vleeschauwer</name></author><author><name sortKey="Willems Widyastuti, A" uniqKey="Willems Widyastuti A">A Willems-Widyastuti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerhardt, Sg" uniqKey="Gerhardt S">SG Gerhardt</name></author><author><name sortKey="Mcdyer, Jf" uniqKey="Mcdyer J">JF McDyer</name></author><author><name sortKey="Girgis, Re" uniqKey="Girgis R">RE Girgis</name></author><author><name sortKey="Conte, Jv" uniqKey="Conte J">JV Conte</name></author><author><name sortKey="Yang, Sc" uniqKey="Yang S">SC Yang</name></author><author><name sortKey="Orens, Jb" uniqKey="Orens J">JB Orens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verleden, Gm" uniqKey="Verleden G">GM Verleden</name></author><author><name sortKey="Vanaudenaerde, Bm" uniqKey="Vanaudenaerde B">BM Vanaudenaerde</name></author><author><name sortKey="Dupont, Lj" uniqKey="Dupont L">LJ Dupont</name></author><author><name sortKey="Van Raemdonck, De" uniqKey="Van Raemdonck D">DE Van Raemdonck</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lung India</journal-id><journal-id journal-id-type="iso-abbrev">Lung India</journal-id><journal-id journal-id-type="publisher-id">LI</journal-id><journal-title-group><journal-title>Lung India : Official Organ of Indian Chest Society</journal-title></journal-title-group><issn pub-type="ppub">0970-2113</issn><issn pub-type="epub">0974-598X</issn><publisher><publisher-name>Wolters Kluwer - Medknow</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31898614</article-id><article-id pub-id-type="pmc">6961095</article-id><article-id pub-id-type="publisher-id">LI-37-8</article-id><article-id pub-id-type="doi">10.4103/lungindia.lungindia_145_19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Clinical profile and course of children with postinfectious bronchiolitis obliterans from a tertiary care hospital</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gulla</surname><given-names>Krishna Mohan</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Jat</surname><given-names>Kana Ram</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Lodha</surname><given-names>Rakesh</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Kabra</surname><given-names>Sushil K</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1"><italic>Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Kana Ram Jat, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi - 110 029, India. E-mail: <email xlink:href="drkanaram@gmail.com">drkanaram@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Feb</season><year>2020</year></pub-date><pub-date pub-type="epub"><day>31</day><month>12</month><year>2019</year></pub-date><volume>37</volume><issue>1</issue><fpage>8</fpage><lpage>12</lpage><history><date date-type="received"><day>04</day><month>4</month><year>2019</year></date><date date-type="accepted"><day>28</day><month>9</month><year>2019</year></date></history><permissions><copyright-statement>Copyright: © 2019 Indian Chest Society</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0"><license-p>This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Postinfectious bronchiolitis obliterans (PIBO) is a chronic obstructive lung disease with scanty information in literature on etiology, clinical profile, treatment, and outcome.</p></sec><sec id="st2"><title>Objective:</title><p>The objective of the study is to describe the clinical profile and course of children diagnosed with PIBO.</p></sec><sec id="st3"><title>Methods:</title><p>A chart review of children below 18 years of age diagnosed as PIBO over the past 9 years was carried out. Details of clinical profile, laboratory investigations, imaging, treatment received, and outcome were recorded.</p></sec><sec id="st4"><title>Results:</title><p>Eight children (boys 4) with PIBO were identified. Median (interquartile range [IQR]) age at the first episode of acute severe bronchiolitis such as illness and diagnosis of PIBO was 15 (6, 23.5) and 30 (16.5, 60) months, respectively, indicating a delay in diagnosis. The most common symptoms were recurrent episodes of cough (100%), fast breathing (100%), wheezing (87.5%), and fever (62.5%). Median (IQR) number of hospitalizations and episodes of antibiotic use prior to diagnosis were 2.5 (2, 5.5) and 2 (2, 4), respectively. Three (37.5%) children received mechanical ventilation during previous hospitalizations. Chest computed tomography revealed mosaic attenuation in 8 (100%), ground-glass opacities in 2 (25%), and bronchial wall thickening in 2 (25%). After diagnosis, 7 received oral steroids, 7 received hydroxychloroquine, 5 received azithromycin, and 2 received azathioprine. The median (IQR) duration of follow-up (<italic>n</italic> = 6) was 6 (1.5, 9.5) months. Median (IQR) number of pulmonary exacerbations in follow-up was 2 (1, 5).</p></sec><sec id="st5"><title>Conclusion:</title><p>PIBO is still an under-recognized entity with substantial delay in diagnosis and unnecessary use of antibiotics. Clinical course with imaging findings may help to diagnose and manage this entity.</p></sec></abstract><kwd-group><title>KEY WORDS:</title><kwd>Children</kwd><kwd>postinfectious bronchiolitis obliterans</kwd><kwd>mosaic attenuation</kwd><kwd>steroids</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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