Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana
Identifieur interne : 000684 ( Pmc/Curation ); précédent : 000683; suivant : 000685Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana
Auteurs : Solomon Opoku [Ghana] ; Isaac Nyanor [Ghana]Source :
- Journal of Tropical Medicine [ 1687-9686 ] ; 2019.
Abstract
Infants and children under five years generally have high susceptibility to pathogenic and opportunistic infections due to immaturity and inexperience of their immune responses. The lives of these young children are threatened when they consume pharmaceutical preparations of poor microbiological quality. Considering the widespread use of artemether-lumefantrine dry powder and paracetamol syrup among the general population in Ghana, there is a need to investigate the microbiological quality and safety of these paediatric pharmaceutical preparations. The study investigated the microbiological quality of 180 samples comprising 90 artemether-lumefantrine dry powders and 90 paracetamol syrups. The samples were tested for presence of specified indicator pathogens, Total Aerobic Microbial Count (TAMC), and Total Yeasts and Moulds Count (TYMC) using compendial procedures. Results from the study indicated that 16 (17.78%) of the paracetamol syrup samples showed bioburden levels above United States Pharmacopeia (USP) maximum acceptable limit, but none of the artemether-lumefantrine dry powder samples recorded microbial load above the limit of USP. Four samples of paracetamol syrup and 4 samples of artemether-lumefantrine dry powder showed presence of
Url:
DOI: 10.1155/2019/7062016
PubMed: 31379951
PubMed Central: 6662472
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana</title>
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<series><title level="j">Journal of Tropical Medicine</title>
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<front><div type="abstract" xml:lang="en"><p>Infants and children under five years generally have high susceptibility to pathogenic and opportunistic infections due to immaturity and inexperience of their immune responses. The lives of these young children are threatened when they consume pharmaceutical preparations of poor microbiological quality. Considering the widespread use of artemether-lumefantrine dry powder and paracetamol syrup among the general population in Ghana, there is a need to investigate the microbiological quality and safety of these paediatric pharmaceutical preparations. The study investigated the microbiological quality of 180 samples comprising 90 artemether-lumefantrine dry powders and 90 paracetamol syrups. The samples were tested for presence of specified indicator pathogens, Total Aerobic Microbial Count (TAMC), and Total Yeasts and Moulds Count (TYMC) using compendial procedures. Results from the study indicated that 16 (17.78%) of the paracetamol syrup samples showed bioburden levels above United States Pharmacopeia (USP) maximum acceptable limit, but none of the artemether-lumefantrine dry powder samples recorded microbial load above the limit of USP. Four samples of paracetamol syrup and 4 samples of artemether-lumefantrine dry powder showed presence of<italic> P</italic>
.<italic> aeruginosa</italic>
, whereas 5 samples of paracetamol syrup were found to be contaminated with<italic> Salmonella</italic>
spp. Overall, 4.44% of the artemether-lumefantrine dry powders and 25.56% of the paracetamol syrups were found to be noncompliant with USP specifications for nonsterile pharmaceutical preparations for oral use. This study has revealed the existence of substandard paediatric pharmaceutical products in the Ghanaian market, hence the need for regulatory bodies to intensify monitoring and postmarketing surveillance programmes to help get rid of these products from the market.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kunuanunua, T S" uniqKey="Kunuanunua T">T. S. Kunuanunua</name>
</author>
<author><name sortKey="Nsibu, C N" uniqKey="Nsibu C">C. N. Nsibu</name>
</author>
<author><name sortKey="Bodi, J M" uniqKey="Bodi J">J. M. Bodi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kweku, M" uniqKey="Kweku M">M. Kweku</name>
</author>
<author><name sortKey="Takramah, W" uniqKey="Takramah W">W. Takramah</name>
</author>
<author><name sortKey="Takase, M" uniqKey="Takase M">M. Takase</name>
</author>
<author><name sortKey="Tarkang, E" uniqKey="Tarkang E">E. Tarkang</name>
</author>
<author><name sortKey="Adjuik, M" uniqKey="Adjuik M">M. Adjuik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buck, M L" uniqKey="Buck M">M. L. Buck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Makanga, M" uniqKey="Makanga M">M. Makanga</name>
</author>
<author><name sortKey="Krudsood, S" uniqKey="Krudsood S">S. Krudsood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mwesigwa, J" uniqKey="Mwesigwa J">J. Mwesigwa</name>
</author>
<author><name sortKey="Parikh, S" uniqKey="Parikh S">S. Parikh</name>
</author>
<author><name sortKey="Mcgee, B" uniqKey="Mcgee B">B. McGee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whitty, C J M" uniqKey="Whitty C">C. J. M. Whitty</name>
</author>
<author><name sortKey="Chandler, C" uniqKey="Chandler C">C. Chandler</name>
</author>
<author><name sortKey="Ansah, E" uniqKey="Ansah E">E. Ansah</name>
</author>
<author><name sortKey="Leslie, T" uniqKey="Leslie T">T. Leslie</name>
</author>
<author><name sortKey="Staedke, S G" uniqKey="Staedke S">S. G. Staedke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prah, J" uniqKey="Prah J">J. Prah</name>
</author>
<author><name sortKey="Ameyaw, E O" uniqKey="Ameyaw E">E. O. Ameyaw</name>
</author>
<author><name sortKey="Afoakwah, R" uniqKey="Afoakwah R">R. Afoakwah</name>
</author>
<author><name sortKey="Fiawoyife, P" uniqKey="Fiawoyife P">P. Fiawoyife</name>
</author>
<author><name sortKey="Oppong Danquah, E" uniqKey="Oppong Danquah E">E. Oppong-Danquah</name>
</author>
<author><name sortKey="Boampong, J N" uniqKey="Boampong J">J. N. Boampong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baba, H" uniqKey="Baba H">H. Baba</name>
</author>
<author><name sortKey="Egbuche, N P" uniqKey="Egbuche N">N. P. Egbuche</name>
</author>
<author><name sortKey="Usifoh, C O" uniqKey="Usifoh C">C. O. Usifoh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Martino, M" uniqKey="De Martino M">M. de Martino</name>
</author>
<author><name sortKey="Chiarugi, A" uniqKey="Chiarugi A">A. Chiarugi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jozwiak Bebenista, M" uniqKey="Jozwiak Bebenista M">M. Jozwiak-Bebenista</name>
</author>
<author><name sortKey="Nowak, J Z" uniqKey="Nowak J">J. Z. Nowak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frimpong, G" uniqKey="Frimpong G">G. Frimpong</name>
</author>
<author><name sortKey="Ofori Kwakye, K" uniqKey="Ofori Kwakye K">K. Ofori-Kwakye</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Adeshina, G O" uniqKey="Adeshina G">G. O. Adeshina</name>
</author>
<author><name sortKey="Ajayi, S" uniqKey="Ajayi S">S. Ajayi</name>
</author>
<author><name sortKey="Onaolapo, J A" uniqKey="Onaolapo J">J. A. Onaolapo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khanom, S" uniqKey="Khanom S">S. Khanom</name>
</author>
<author><name sortKey="Das, K K" uniqKey="Das K">K. K. Das</name>
</author>
<author><name sortKey="Banik, S" uniqKey="Banik S">S. Banik</name>
</author>
<author><name sortKey="Noor, R" uniqKey="Noor R">R. Noor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naveed, Q" uniqKey="Naveed Q">Q. Naveed</name>
</author>
<author><name sortKey="Hashmi, S" uniqKey="Hashmi S">S. Hashmi</name>
</author>
<author><name sortKey="Iqbal, A" uniqKey="Iqbal A">A. Iqbal</name>
</author>
<author><name sortKey="Khan, A J" uniqKey="Khan A">A. J. Khan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Housseiny, R" uniqKey="El Housseiny R">R. El-Housseiny</name>
</author>
<author><name sortKey="Aboulwafa, M M" uniqKey="Aboulwafa M">M. M. Aboulwafa</name>
</author>
<author><name sortKey="Aboulwafa, E W" uniqKey="Aboulwafa E">E. W. Aboulwafa</name>
</author>
<author><name sortKey="Hassouna, N" uniqKey="Hassouna N">N. Hassouna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aulton, M E" uniqKey="Aulton M">M. E. Aulton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parker, M S" uniqKey="Parker M">M. S. Parker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mwambete, K D" uniqKey="Mwambete K">K. D. Mwambete</name>
</author>
<author><name sortKey="Justin Temu, M" uniqKey="Justin Temu M">M. Justin-Temu</name>
</author>
<author><name sortKey="Fazleabbas, F S" uniqKey="Fazleabbas F">F. S. Fazleabbas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruckwardt, T J" uniqKey="Ruckwardt T">T. J. Ruckwardt</name>
</author>
<author><name sortKey="Malloy, A M" uniqKey="Malloy A">A. M. Malloy</name>
</author>
<author><name sortKey="Morabito, K M" uniqKey="Morabito K">K. M. Morabito</name>
</author>
<author><name sortKey="Graham, B S" uniqKey="Graham B">B. S. Graham</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daniyan, S Y" uniqKey="Daniyan S">S. Y. Daniyan</name>
</author>
<author><name sortKey="Sangodere, T A" uniqKey="Sangodere T">T. A. Sangodere</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bykowski, T" uniqKey="Bykowski T">T. Bykowski</name>
</author>
<author><name sortKey="Stevenson, B" uniqKey="Stevenson B">B. Stevenson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Niskanen, T" uniqKey="Niskanen T">T. Niskanen</name>
</author>
<author><name sortKey="Laukkanen, R" uniqKey="Laukkanen R">R. Laukkanen</name>
</author>
<author><name sortKey="Murros, A" uniqKey="Murros A">A. Murros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feglo, P" uniqKey="Feglo P">P. Feglo</name>
</author>
<author><name sortKey="Opoku, S" uniqKey="Opoku S">S. Opoku</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bannerman, T L" uniqKey="Bannerman T">T. L. Bannerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khanna, M" uniqKey="Khanna M">M. Khanna</name>
</author>
<author><name sortKey="Teotia, U V S" uniqKey="Teotia U">U. V. S. Teotia</name>
</author>
<author><name sortKey="Singh, Y" uniqKey="Singh Y">Y. Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bassat, Q" uniqKey="Bassat Q">Q. Bassat</name>
</author>
<author><name sortKey="Ogutu, B" uniqKey="Ogutu B">B. Ogutu</name>
</author>
<author><name sortKey="Djimde, A" uniqKey="Djimde A">A. Djimde</name>
</author>
<author><name sortKey="Stricker, K" uniqKey="Stricker K">K. Stricker</name>
</author>
<author><name sortKey="Hamed, K" uniqKey="Hamed K">K. Hamed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Najmuddin, M" uniqKey="Najmuddin M">M. Najmuddin</name>
</author>
<author><name sortKey="Patel, V" uniqKey="Patel V">V. Patel</name>
</author>
<author><name sortKey="Ahmed, A" uniqKey="Ahmed A">A. Ahmed</name>
</author>
<author><name sortKey="Shelar, S" uniqKey="Shelar S">S. Shelar</name>
</author>
<author><name sortKey="Khan, T" uniqKey="Khan T">T. Khan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gautam, A K" uniqKey="Gautam A">A. K. Gautam</name>
</author>
<author><name sortKey="Sharma, S" uniqKey="Sharma S">S. Sharma</name>
</author>
<author><name sortKey="Bhadauria, R" uniqKey="Bhadauria R">R. Bhadauria</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moniruzzaman, M" uniqKey="Moniruzzaman M">M. Moniruzzaman</name>
</author>
<author><name sortKey="Faisal Ashrafi, M F" uniqKey="Faisal Ashrafi M">M. F. Faisal Ashrafi</name>
</author>
<author><name sortKey="Mia, Z" uniqKey="Mia Z">Z. Mia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hossain, M" uniqKey="Hossain M">M. Hossain</name>
</author>
<author><name sortKey="Ara, S" uniqKey="Ara S">S. Ara</name>
</author>
<author><name sortKey="Rahman, M Z" uniqKey="Rahman M">M. Z. Rahman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gad, G" uniqKey="Gad G">G. Gad</name>
</author>
<author><name sortKey="Aly, R" uniqKey="Aly R">R. Aly</name>
</author>
<author><name sortKey="Ashour, M" uniqKey="Ashour M">M. Ashour</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoq, M M" uniqKey="Hoq M">M. M. Hoq</name>
</author>
<author><name sortKey="Syeda, M B" uniqKey="Syeda M">M. B. Syeda</name>
</author>
<author><name sortKey="Gomes, D J" uniqKey="Gomes D">D. J. Gomes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finn, S" uniqKey="Finn S">S. Finn</name>
</author>
<author><name sortKey="Condell, O" uniqKey="Condell O">O. Condell</name>
</author>
<author><name sortKey="Mcclure, P" uniqKey="Mcclure P">P. McClure</name>
</author>
<author><name sortKey="Amezquita, A" uniqKey="Amezquita A">A. Amézquita</name>
</author>
<author><name sortKey="Fanning, S" uniqKey="Fanning S">S. Fanning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siroli, L" uniqKey="Siroli L">L. Siroli</name>
</author>
<author><name sortKey="Patrignani, F" uniqKey="Patrignani F">F. Patrignani</name>
</author>
<author><name sortKey="Serrazanetti, D I" uniqKey="Serrazanetti D">D. I. Serrazanetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hedge, A" uniqKey="Hedge A">A. Hedge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ofori Kwakye, K" uniqKey="Ofori Kwakye K">K. Ofori-Kwakye</name>
</author>
<author><name sortKey="Asantewaa, Y" uniqKey="Asantewaa Y">Y. Asantewaa</name>
</author>
<author><name sortKey="Gaye, O" uniqKey="Gaye O">O. Gaye</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Trop Med</journal-id>
<journal-id journal-id-type="iso-abbrev">J Trop Med</journal-id>
<journal-id journal-id-type="publisher-id">JTM</journal-id>
<journal-title-group><journal-title>Journal of Tropical Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1687-9686</issn>
<issn pub-type="epub">1687-9694</issn>
<publisher><publisher-name>Hindawi</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31379951</article-id>
<article-id pub-id-type="pmc">6662472</article-id>
<article-id pub-id-type="doi">10.1155/2019/7062016</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-2541-466X</contrib-id>
<name><surname>Opoku</surname>
<given-names>Solomon</given-names>
</name>
<email>slmnopoku@gmail.com</email>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nyanor</surname>
<given-names>Isaac</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Quality Control Department, Entrance Pharmaceuticals and Research Centre, No. 16 Okpoi Gonno, Spintex Road, Post Office Box CT 10805, Accra, Ghana</aff>
<aff id="I2"><sup>2</sup>
Sickle Pan Africa Research Consortium, Kumasi Centre for Sickle Cell Disease, Komfo Anokye Teaching Hospital, Kumasi, Ghana</aff>
<author-notes><fn fn-type="other"><p>Academic Editor: Aditya Prasad Dash</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>14</day>
<month>7</month>
<year>2019</year>
</pub-date>
<volume>2019</volume>
<elocation-id>7062016</elocation-id>
<history><date date-type="received"><day>11</day>
<month>3</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>7</day>
<month>7</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2019 Solomon Opoku and Isaac Nyanor.</copyright-statement>
<copyright-year>2019</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Infants and children under five years generally have high susceptibility to pathogenic and opportunistic infections due to immaturity and inexperience of their immune responses. The lives of these young children are threatened when they consume pharmaceutical preparations of poor microbiological quality. Considering the widespread use of artemether-lumefantrine dry powder and paracetamol syrup among the general population in Ghana, there is a need to investigate the microbiological quality and safety of these paediatric pharmaceutical preparations. The study investigated the microbiological quality of 180 samples comprising 90 artemether-lumefantrine dry powders and 90 paracetamol syrups. The samples were tested for presence of specified indicator pathogens, Total Aerobic Microbial Count (TAMC), and Total Yeasts and Moulds Count (TYMC) using compendial procedures. Results from the study indicated that 16 (17.78%) of the paracetamol syrup samples showed bioburden levels above United States Pharmacopeia (USP) maximum acceptable limit, but none of the artemether-lumefantrine dry powder samples recorded microbial load above the limit of USP. Four samples of paracetamol syrup and 4 samples of artemether-lumefantrine dry powder showed presence of<italic> P</italic>
.<italic> aeruginosa</italic>
, whereas 5 samples of paracetamol syrup were found to be contaminated with<italic> Salmonella</italic>
spp. Overall, 4.44% of the artemether-lumefantrine dry powders and 25.56% of the paracetamol syrups were found to be noncompliant with USP specifications for nonsterile pharmaceutical preparations for oral use. This study has revealed the existence of substandard paediatric pharmaceutical products in the Ghanaian market, hence the need for regulatory bodies to intensify monitoring and postmarketing surveillance programmes to help get rid of these products from the market.</p>
</abstract>
</article-meta>
</front>
<floats-group><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label>
<caption><p>Proportion of products stratified by dosage forms, packaging materials, sources, and pathogens.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="left" colspan="1">Variable</th>
<th colspan="2" align="center" rowspan="1">Product Type</th>
</tr>
<tr><th align="center" rowspan="1" colspan="1">Artemether-lumefantrine dry powder, N=90</th>
<th align="center" rowspan="1" colspan="1">Paracetamol syrup, N=90</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">Dosage form</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Dry Powder for Oral Suspension</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Syrup</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">90</td>
</tr>
<tr><td colspan="3" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Primary packaging material</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Amber Glass Bottle</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">90</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">PET Bottle</td>
<td align="center" rowspan="1" colspan="1">79</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Sachet</td>
<td align="center" rowspan="1" colspan="1">11</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr><td colspan="3" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Source of product</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">OTCMO</td>
<td align="center" rowspan="1" colspan="1">33</td>
<td align="center" rowspan="1" colspan="1">33</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Pharmacy Shop</td>
<td align="center" rowspan="1" colspan="1">57</td>
<td align="center" rowspan="1" colspan="1">57</td>
</tr>
<tr><td colspan="3" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Indicator Pathogens</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>E. coli</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>Salmonella spp.</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">5</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">85</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>P. aeruginosa </italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">4</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">86</td>
<td align="center" rowspan="1" colspan="1">86</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>S. aureus</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tab2" content-type="sidewaystable" orientation="portrait" position="float"><label>Table 2</label>
<caption><p>Results of the microbiological analyses of artemether-lumefantrine dry powder and paracetamol syrup.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="4" align="left" colspan="1">Brand</th>
<th rowspan="4" align="center" colspan="1">Sample No.</th>
<th colspan="6" align="center" rowspan="1">Artemether-lumefantrine Dry Powder</th>
<th colspan="6" align="center" rowspan="1">Paracetamol Syrup</th>
</tr>
<tr><th colspan="2" align="center" rowspan="1">Microbial Count</th>
<th colspan="4" align="center" rowspan="1">Pathogens</th>
<th colspan="2" align="center" rowspan="1">Microbial Count</th>
<th colspan="4" align="center" rowspan="1">Pathogens</th>
</tr>
<tr><th align="center" rowspan="1" colspan="1">TAMC</th>
<th align="center" rowspan="1" colspan="1">TYMC</th>
<th rowspan="2" align="center" colspan="1"><italic>E</italic>
. <italic>coli</italic>
</th>
<th rowspan="2" align="center" colspan="1"><italic>Salmonella</italic>
spp.</th>
<th rowspan="2" align="center" colspan="1"><italic>P</italic>
. <italic>aeruginosa</italic>
</th>
<th rowspan="2" align="center" colspan="1"><italic>S</italic>
. <italic>aureus</italic>
</th>
<th align="center" rowspan="1" colspan="1">TAMC</th>
<th align="center" rowspan="1" colspan="1">TYMC</th>
<th rowspan="2" align="center" colspan="1"><italic>E</italic>
. <italic>coli</italic>
</th>
<th rowspan="2" align="center" colspan="1"><italic>Salmonella</italic>
spp.</th>
<th rowspan="2" align="center" colspan="1"><italic>P</italic>
. <italic>aeruginosa</italic>
</th>
<th rowspan="2" align="center" colspan="1"><italic>S</italic>
. <italic>aureus</italic>
</th>
</tr>
<tr><th align="center" rowspan="1" colspan="1">(cfu/g)</th>
<th align="center" rowspan="1" colspan="1">(cfu/g)</th>
<th align="center" rowspan="1" colspan="1">(cfu/mL)</th>
<th align="center" rowspan="1" colspan="1">(cfu/mL)</th>
</tr>
</thead>
<tbody><tr><td rowspan="10" align="left" colspan="1">A</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">B</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">7.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">4.3 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.25 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">4.15 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">9.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.7 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.15 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">4.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">5.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.85 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">8.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">6.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">5.05 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">8.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">8.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">4.36 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">8.85 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">6.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.85 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">7.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">5.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">7.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">C</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.9 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.1 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">D</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.4 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.25 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">4.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.7 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">E</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">5.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">9.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">4.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">4.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">9.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">5.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">9.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">F</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.65 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">9.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">5.15 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.85 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">G</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.75 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.10 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.65 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">4.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">H</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">4.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">9.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.60 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.05 x 10<sup>2</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td colspan="14" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td rowspan="10" align="left" colspan="1">I</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">2.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">2.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">6</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">3.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">9</td>
<td align="center" rowspan="1" colspan="1">5.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">Present</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
<tr><td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">1.5 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">1.0 x 10<sup>1</sup>
</td>
<td align="center" rowspan="1" colspan="1">< 10</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
<td align="center" rowspan="1" colspan="1">ND</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>TAMC: Total Aerobic Microbial Count, TYMC: Total Yeasts and Moulds Count, cfu: colony-forming units, ND: not detected.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tab3" orientation="portrait" position="float"><label>Table 3</label>
<caption><p>Associations between product type and presence of pathogens.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="left" colspan="1">Pathogen</th>
<th colspan="2" align="center" rowspan="1">Product Type</th>
<th rowspan="2" align="center" colspan="1">Total</th>
<th rowspan="2" align="center" colspan="1">p-value</th>
</tr>
<tr><th align="center" rowspan="1" colspan="1">Artemether-lumefantrine Dry Powder</th>
<th align="center" rowspan="1" colspan="1">Paracetamol Syrup</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1"><italic>Salmonella</italic>
spp.</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">85</td>
<td align="center" rowspan="1" colspan="1">175</td>
<td align="center" rowspan="1" colspan="1"><italic>0.03∗</italic>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Total</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td colspan="5" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>P. aeruginosa</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">86</td>
<td align="center" rowspan="1" colspan="1">86</td>
<td align="center" rowspan="1" colspan="1">172</td>
<td align="center" rowspan="1" colspan="1">0.64</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Total</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td colspan="5" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>S. aureus</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1">-</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Total</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td colspan="5" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>E. coli</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1">-</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Total</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p><bold>∗</bold>
<italic>Fisher's test.</italic>
P< 0.05 means significant; P> 0.05 means not significant.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tab4" orientation="portrait" position="float"><label>Table 4</label>
<caption><p>Relationship between the levels of contamination (TAMC) and presence of <italic>P</italic>
. <italic>aeruginosa</italic>
in the products packaged in amber glass bottles and PET bottles.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">TAMC/Material Type/Disease-causing organisms </th>
<th align="center" rowspan="1" colspan="1">Observation</th>
<th align="center" rowspan="1" colspan="1">Wilcoxon Rank sum test</th>
<th align="center" rowspan="1" colspan="1">Expected frequency</th>
<th align="center" rowspan="1" colspan="1">p value</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">Material Type (Amber Glass Bottle)</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>P</italic>
. <italic>aeruginosa</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">86</td>
<td align="center" rowspan="1" colspan="1">3949.5</td>
<td align="center" rowspan="1" colspan="1">3913</td>
<td align="center" rowspan="1" colspan="1">0.4597</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">145.5</td>
<td align="center" rowspan="1" colspan="1">182</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Combined</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">4095</td>
<td align="center" rowspan="1" colspan="1">4095</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Material Type (PET Bottle)</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"><italic>P</italic>
. <italic>aeruginosa</italic>
</td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Absent</td>
<td align="center" rowspan="1" colspan="1">75</td>
<td align="center" rowspan="1" colspan="1">2879</td>
<td align="center" rowspan="1" colspan="1">3000</td>
<td align="center" rowspan="1" colspan="1"><italic>0.0062</italic>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Detected</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">281</td>
<td align="center" rowspan="1" colspan="1">160</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Combined</td>
<td align="center" rowspan="1" colspan="1">79</td>
<td align="center" rowspan="1" colspan="1">3160</td>
<td align="center" rowspan="1" colspan="1">3160</td>
<td align="center" rowspan="1" colspan="1"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>P< 0.05 means significant; P> 0.05 means not significant.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>
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