Transient receptor potential melastatin 2–mediated heme oxygenase-1 has a role for bacterial clearance by regulating autophagy in peritoneal macrophages during polymicrobial sepsis
Identifieur interne : 000591 ( Pmc/Curation ); précédent : 000590; suivant : 000592Transient receptor potential melastatin 2–mediated heme oxygenase-1 has a role for bacterial clearance by regulating autophagy in peritoneal macrophages during polymicrobial sepsis
Auteurs : Xiaowei Qian [République populaire de Chine] ; Hao Cheng [République populaire de Chine] ; Xinzhong Chen [République populaire de Chine]Source :
- Innate Immunity [ 1753-4259 ] ; 2019.
Abstract
Our previous study indicated an important protective role of transient receptor potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages during polymicrobial sepsis by regulating heme oxygenase-1. Autophagy is necessary for macrophages to kill invasive bacteria. In the present study, TRPM2 knockout (KO) mice show decreased heme oxygenase-1 and autophagy in peritoneal macrophages after caecal ligation and puncture surgery. Caecal ligation and puncture-induced autophagy in peritoneal macrophages is dependent on heme oxygenase-1. TRPM2 KO mice treated with heme oxygenase-1 inducer before caecal ligation and puncture significantly increase autophagy of peritoneal macrophages, bacterial clearance rate and survival rate. In addition, TRPM2 KO mice treated with heme oxygenase-1 inducer before caecal ligation and puncture significantly attenuate organ injury and systemic inflammation. These improvements are reversed by autophagy inhibitor. Therefore, our findings suggest that TRPM2-mediated heme oxygenase-1 has a role for bacterial clearance possibly by regulating autophagy in peritoneal macrophages during polymicrobial sepsis.
Url:
DOI: 10.1177/1753425919875796
PubMed: 31533549
PubMed Central: 6900664
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macrophages during polymicrobial sepsis</title>
<author><name sortKey="Qian, Xiaowei" sort="Qian, Xiaowei" uniqKey="Qian X" first="Xiaowei" last="Qian">Xiaowei Qian</name>
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<series><title level="j">Innate Immunity</title>
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<front><div type="abstract" xml:lang="en"><p>Our previous study indicated an important protective role of transient receptor
potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages
during polymicrobial sepsis by regulating heme oxygenase-1. Autophagy is
necessary for macrophages to kill invasive bacteria. In the present study, TRPM2
knockout (KO) mice show decreased heme oxygenase-1 and autophagy in peritoneal
macrophages after caecal ligation and puncture surgery. Caecal ligation and
puncture-induced autophagy in peritoneal macrophages is dependent on heme
oxygenase-1. TRPM2 KO mice treated with heme oxygenase-1 inducer before caecal
ligation and puncture significantly increase autophagy of peritoneal
macrophages, bacterial clearance rate and survival rate. In addition, TRPM2 KO
mice treated with heme oxygenase-1 inducer before caecal ligation and puncture
significantly attenuate organ injury and systemic inflammation. These
improvements are reversed by autophagy inhibitor. Therefore, our findings
suggest that TRPM2-mediated heme oxygenase-1 has a role for bacterial clearance
possibly by regulating autophagy in peritoneal macrophages during polymicrobial
sepsis.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Innate Immun</journal-id>
<journal-id journal-id-type="iso-abbrev">Innate Immun</journal-id>
<journal-id journal-id-type="publisher-id">INI</journal-id>
<journal-id journal-id-type="hwp">spini</journal-id>
<journal-title-group><journal-title>Innate Immunity</journal-title>
</journal-title-group>
<issn pub-type="ppub">1753-4259</issn>
<issn pub-type="epub">1753-4267</issn>
<publisher><publisher-name>SAGE Publications</publisher-name>
<publisher-loc>Sage UK: London, England</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31533549</article-id>
<article-id pub-id-type="pmc">6900664</article-id>
<article-id pub-id-type="doi">10.1177/1753425919875796</article-id>
<article-id pub-id-type="publisher-id">10.1177_1753425919875796</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Transient receptor potential melastatin 2–mediated heme oxygenase-1
has a role for bacterial clearance by regulating autophagy in peritoneal
macrophages during polymicrobial sepsis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0001-9553-1098</contrib-id>
<name><surname>Qian</surname>
<given-names>XiaoWei</given-names>
</name>
<xref ref-type="aff" rid="aff1-1753425919875796">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Hao</given-names>
</name>
<xref ref-type="aff" rid="aff1-1753425919875796">1</xref>
<xref ref-type="aff" rid="aff2-1753425919875796">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>XinZhong</given-names>
</name>
<xref ref-type="aff" rid="aff1-1753425919875796">1</xref>
<xref ref-type="corresp" rid="corresp1-1753425919875796"></xref>
</contrib>
<aff id="aff1-1753425919875796"><label>1</label>
Department of Anaesthesia, Women’s Hospital, Zhejiang University School of Medicine, PR China</aff>
<aff id="aff2-1753425919875796"><label>2</label>
Department of Anaesthesia, Lishui Municipal Central Hospital, PR China</aff>
</contrib-group>
<author-notes><corresp id="corresp1-1753425919875796">XinZhong Chen, Department of Anaesthesia,
Women’s Hospital, Zhejiang University School of Medicine, Xueshi Road 1,
Hangzhou 310006, PR China. Email: <email>chenxinz@zju.edu.cn</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>19</day>
<month>9</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="ppub"><month>11</month>
<year>2019</year>
</pub-date>
<volume>25</volume>
<issue>8</issue>
<fpage>530</fpage>
<lpage>538</lpage>
<history><date date-type="received"><day>3</day>
<month>4</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>21</day>
<month>8</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2019</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder content-type="society">SAGE Publications Ltd unless otherwise
noted. Manuscript content on this site is licensed under Creative Commons
Licenses</copyright-holder>
<license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>Creative Commons Non Commercial CC BY-NC: This article is distributed
under the terms of the Creative Commons Attribution-NonCommercial 4.0
License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by-nc/4.0/">http://www.creativecommons.org/licenses/by-nc/4.0/</ext-link>
) which
permits non-commercial use, reproduction and distribution of the work
without further permission provided the original work is attributed as
specified on the SAGE and Open Access pages (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>
).</license-p>
</license>
</permissions>
<abstract abstract-type="short"><p>Our previous study indicated an important protective role of transient receptor
potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages
during polymicrobial sepsis by regulating heme oxygenase-1. Autophagy is
necessary for macrophages to kill invasive bacteria. In the present study, TRPM2
knockout (KO) mice show decreased heme oxygenase-1 and autophagy in peritoneal
macrophages after caecal ligation and puncture surgery. Caecal ligation and
puncture-induced autophagy in peritoneal macrophages is dependent on heme
oxygenase-1. TRPM2 KO mice treated with heme oxygenase-1 inducer before caecal
ligation and puncture significantly increase autophagy of peritoneal
macrophages, bacterial clearance rate and survival rate. In addition, TRPM2 KO
mice treated with heme oxygenase-1 inducer before caecal ligation and puncture
significantly attenuate organ injury and systemic inflammation. These
improvements are reversed by autophagy inhibitor. Therefore, our findings
suggest that TRPM2-mediated heme oxygenase-1 has a role for bacterial clearance
possibly by regulating autophagy in peritoneal macrophages during polymicrobial
sepsis.</p>
</abstract>
<kwd-group><kwd>Transient receptor potential melastatin 2</kwd>
<kwd>heme oxygenase-1</kwd>
<kwd>autophagy</kwd>
<kwd>macrophage</kwd>
<kwd>sepsis</kwd>
</kwd-group>
<funding-group><award-group id="award1-1753425919875796"><funding-source id="funding1-1753425919875796"><institution-wrap><institution>National Natural Science Foundation of China</institution>
<institution-id institution-id-type="FundRef">http://doi.org/10.13039/501100001809</institution-id>
</institution-wrap>
</funding-source>
<award-id rid="funding1-1753425919875796">81501702</award-id>
</award-group>
<award-group id="award2-1753425919875796"><funding-source id="funding2-1753425919875796"><institution-wrap><institution>Natural Science Foundation of Zhejiang
Province</institution>
<institution-id institution-id-type="FundRef">http://doi.org/10.13039/501100004731</institution-id>
</institution-wrap>
</funding-source>
<award-id rid="funding2-1753425919875796">LY15H150007</award-id>
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</front>
</pmc>
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