Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis
Identifieur interne : 000472 ( Pmc/Curation ); précédent : 000471; suivant : 000473Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis
Auteurs : Naveed Sabir ; Tariq Hussain ; Yi Liao ; Jie Wang ; Yinjuan Song ; Muhammad Shahid ; Guangyu Cheng ; Mazhar Hussain Mangi ; Jiao Yao ; Lifeng Yang ; Deming Zhao ; Xiangmei ZhouSource :
- Cells [ 2073-4409 ] ; 2019.
Abstract
Url:
DOI: 10.3390/cells8050415
PubMed: 31060300
PubMed Central: 6562459
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against <italic>Mycobacterium bovis</italic>
Infection by Modulating Autophagy and Apoptosis</title>
<author><name sortKey="Sabir, Naveed" sort="Sabir, Naveed" uniqKey="Sabir N" first="Naveed" last="Sabir">Naveed Sabir</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hussain, Tariq" sort="Hussain, Tariq" uniqKey="Hussain T" first="Tariq" last="Hussain">Tariq Hussain</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liao, Yi" sort="Liao, Yi" uniqKey="Liao Y" first="Yi" last="Liao">Yi Liao</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Jie" sort="Wang, Jie" uniqKey="Wang J" first="Jie" last="Wang">Jie Wang</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Song, Yinjuan" sort="Song, Yinjuan" uniqKey="Song Y" first="Yinjuan" last="Song">Yinjuan Song</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shahid, Muhammad" sort="Shahid, Muhammad" uniqKey="Shahid M" first="Muhammad" last="Shahid">Muhammad Shahid</name>
<affiliation><nlm:aff id="af2-cells-08-00415">Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>drshahid_vet@yahoo.com</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheng, Guangyu" sort="Cheng, Guangyu" uniqKey="Cheng G" first="Guangyu" last="Cheng">Guangyu Cheng</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mangi, Mazhar Hussain" sort="Mangi, Mazhar Hussain" uniqKey="Mangi M" first="Mazhar Hussain" last="Mangi">Mazhar Hussain Mangi</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yao, Jiao" sort="Yao, Jiao" uniqKey="Yao J" first="Jiao" last="Yao">Jiao Yao</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Lifeng" sort="Yang, Lifeng" uniqKey="Yang L" first="Lifeng" last="Yang">Lifeng Yang</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhao, Deming" sort="Zhao, Deming" uniqKey="Zhao D" first="Deming" last="Zhao">Deming Zhao</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhou, Xiangmei" sort="Zhou, Xiangmei" uniqKey="Zhou X" first="Xiangmei" last="Zhou">Xiangmei Zhou</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against <italic>Mycobacterium bovis</italic>
Infection by Modulating Autophagy and Apoptosis</title>
<author><name sortKey="Sabir, Naveed" sort="Sabir, Naveed" uniqKey="Sabir N" first="Naveed" last="Sabir">Naveed Sabir</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hussain, Tariq" sort="Hussain, Tariq" uniqKey="Hussain T" first="Tariq" last="Hussain">Tariq Hussain</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liao, Yi" sort="Liao, Yi" uniqKey="Liao Y" first="Yi" last="Liao">Yi Liao</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Jie" sort="Wang, Jie" uniqKey="Wang J" first="Jie" last="Wang">Jie Wang</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Song, Yinjuan" sort="Song, Yinjuan" uniqKey="Song Y" first="Yinjuan" last="Song">Yinjuan Song</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shahid, Muhammad" sort="Shahid, Muhammad" uniqKey="Shahid M" first="Muhammad" last="Shahid">Muhammad Shahid</name>
<affiliation><nlm:aff id="af2-cells-08-00415">Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>drshahid_vet@yahoo.com</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheng, Guangyu" sort="Cheng, Guangyu" uniqKey="Cheng G" first="Guangyu" last="Cheng">Guangyu Cheng</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mangi, Mazhar Hussain" sort="Mangi, Mazhar Hussain" uniqKey="Mangi M" first="Mazhar Hussain" last="Mangi">Mazhar Hussain Mangi</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yao, Jiao" sort="Yao, Jiao" uniqKey="Yao J" first="Jiao" last="Yao">Jiao Yao</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Lifeng" sort="Yang, Lifeng" uniqKey="Yang L" first="Lifeng" last="Yang">Lifeng Yang</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhao, Deming" sort="Zhao, Deming" uniqKey="Zhao D" first="Deming" last="Zhao">Deming Zhao</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhou, Xiangmei" sort="Zhou, Xiangmei" uniqKey="Zhou X" first="Xiangmei" last="Zhou">Xiangmei Zhou</name>
<affiliation><nlm:aff id="af1-cells-08-00415">Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</nlm:aff>
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</author>
</analytic>
<series><title level="j">Cells</title>
<idno type="eISSN">2073-4409</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><italic>Mycobacterium bovis</italic>
(<italic>M. bovis</italic>
) is a member of the <italic>Mycobacterium tuberculosis</italic>
(<italic>Mtb</italic>
) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological processes, it is likely that KLKs expression may mediate a host immune response against the <italic>M. bovis</italic>
infection. In the current study, we report in vivo and in vitro upregulation of KLK12 in the <italic>M. bovis</italic>
infection. To define the role of KLK12 in immune response regulation of murine macrophages, we produced KLK12 knockdown bone marrow derived macrophages (BMDMs) by using siRNA transfection. Interestingly, the knockdown of KLK12 resulted in a significant downregulation of autophagy and apoptosis in <italic>M. bovis</italic>
infected BMDMs. Furthermore, we demonstrated that this KLK12 mediated regulation of autophagy and apoptosis involves mTOR/AMPK/TSC2 and BAX/Bcl-2/Cytochrome c/Caspase 3 pathways, respectively. Similarly, inflammatory cytokines IL-1β, IL-6, IL-12 and TNF-α were significantly downregulated in KLK12 knockdown macrophages but the difference in IL-10 and IFN-β expression was non-significant. Taken together, these findings suggest that upregulation of KLK12 in <italic>M. bovis</italic>
infected murine macrophages plays a substantial role in the protective immune response regulation by modulating autophagy, apoptosis and pro-inflammatory pathways. To our knowledge, this is the first report on expression and the role of KLK12 in the <italic>M. bovis</italic>
infection and the data may contribute to a new paradigm for diagnosis and treatment of bovine TB.</p>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cells</journal-id>
<journal-id journal-id-type="iso-abbrev">Cells</journal-id>
<journal-id journal-id-type="publisher-id">cells</journal-id>
<journal-title-group><journal-title>Cells</journal-title>
</journal-title-group>
<issn pub-type="epub">2073-4409</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31060300</article-id>
<article-id pub-id-type="pmc">6562459</article-id>
<article-id pub-id-type="doi">10.3390/cells8050415</article-id>
<article-id pub-id-type="publisher-id">cells-08-00415</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against <italic>Mycobacterium bovis</italic>
Infection by Modulating Autophagy and Apoptosis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sabir</surname>
<given-names>Naveed</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hussain</surname>
<given-names>Tariq</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liao</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Jie</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Song</surname>
<given-names>Yinjuan</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shahid</surname>
<given-names>Muhammad</given-names>
</name>
<xref ref-type="aff" rid="af2-cells-08-00415">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Guangyu</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mangi</surname>
<given-names>Mazhar Hussain</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yao</surname>
<given-names>Jiao</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Lifeng</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Deming</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1566-5745</contrib-id>
<name><surname>Zhou</surname>
<given-names>Xiangmei</given-names>
</name>
<xref ref-type="aff" rid="af1-cells-08-00415">1</xref>
<xref rid="c1-cells-08-00415" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-cells-08-00415"><label>1</label>
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>naveedsabir@upr.edu.pk</email>
(N.S.);<email>drtariq@aup.edu.pk</email>
(T.H.);<email>liaoyi_cau@126.com</email>
(Y.L.);<email>wangjie1985abc@163.com</email>
(J.W.);<email>syinjuan@126.com</email>
(Y.S.);<email>hnchdd@163.com</email>
(G.C.);<email>drmazharmangi114@gmail.com</email>
(M.H.M.);<email>mole-yao@hotmail.com</email>
(J.Y.);<email>yanglf@cau.edu.cn</email>
(L.Y.);<email>zhaodm@cau.edu.cn</email>
(D.Z.)</aff>
<aff id="af2-cells-08-00415"><label>2</label>
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;<email>drshahid_vet@yahoo.com</email>
</aff>
<author-notes><corresp id="c1-cells-08-00415"><label>*</label>
Correspondence: <email>zhouxm@cau.edu.cn</email>
; Tel.: +86-10-62734618</corresp>
</author-notes>
<pub-date pub-type="epub"><day>05</day>
<month>5</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><month>5</month>
<year>2019</year>
</pub-date>
<volume>8</volume>
<issue>5</issue>
<elocation-id>415</elocation-id>
<history><date date-type="received"><day>18</day>
<month>3</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>30</day>
<month>4</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 by the authors.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p><italic>Mycobacterium bovis</italic>
(<italic>M. bovis</italic>
) is a member of the <italic>Mycobacterium tuberculosis</italic>
(<italic>Mtb</italic>
) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological processes, it is likely that KLKs expression may mediate a host immune response against the <italic>M. bovis</italic>
infection. In the current study, we report in vivo and in vitro upregulation of KLK12 in the <italic>M. bovis</italic>
infection. To define the role of KLK12 in immune response regulation of murine macrophages, we produced KLK12 knockdown bone marrow derived macrophages (BMDMs) by using siRNA transfection. Interestingly, the knockdown of KLK12 resulted in a significant downregulation of autophagy and apoptosis in <italic>M. bovis</italic>
infected BMDMs. Furthermore, we demonstrated that this KLK12 mediated regulation of autophagy and apoptosis involves mTOR/AMPK/TSC2 and BAX/Bcl-2/Cytochrome c/Caspase 3 pathways, respectively. Similarly, inflammatory cytokines IL-1β, IL-6, IL-12 and TNF-α were significantly downregulated in KLK12 knockdown macrophages but the difference in IL-10 and IFN-β expression was non-significant. Taken together, these findings suggest that upregulation of KLK12 in <italic>M. bovis</italic>
infected murine macrophages plays a substantial role in the protective immune response regulation by modulating autophagy, apoptosis and pro-inflammatory pathways. To our knowledge, this is the first report on expression and the role of KLK12 in the <italic>M. bovis</italic>
infection and the data may contribute to a new paradigm for diagnosis and treatment of bovine TB.</p>
</abstract>
<kwd-group><kwd><italic>Mycobacterium bovis</italic>
</kwd>
<kwd>murine macrophages</kwd>
<kwd>Kallikrein12</kwd>
<kwd>autophagy</kwd>
<kwd>apoptosis</kwd>
<kwd>cytokines</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="cells-08-00415-f001" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p><italic>Mycobacterium bovis</italic>
(<italic>M. bovis</italic>
) infection upregulates KLK12 expression in mice and murine macrophages. (<bold>A, B</bold>
) Mice (<italic>n</italic>
= 10) were intranasally infected with <italic>M. bovis</italic>
C68004 (at a dose of 200 CFU/mouse) or with PBS. Mice were sacrificed after 3 and 12 weeks of infection, and lungs and spleens were collected. KLK12 expression was detected by Quantitative Real-Time PCR (qRT-PCR); (<bold>C</bold>
) RAW264.7 cells were infected with <italic>M. bovis</italic>
C68004 at a variable multiplicity of infection (MOI) (5, 10, 20 and 40) and incubated for 24 h; (<bold>D</bold>
) RAW264.7 cells were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated time periods, i.e., 0, 6, 12, 18 and 24 h; (<bold>E</bold>
) BMDMs were infected with <italic>M. bovis</italic>
C68004 at a variable multiplicity of infection (MOI) (5, 10, 20 and 40) and incubated for 24 h; (<bold>F</bold>
) BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated time periods, i.e., 0, 6, 12, 18 and 24 h; (<bold>G</bold>
) RAW264.7 cells were infected with <italic>M. bovis</italic>
N strain at a variable multiplicity of infection (MOI) (5, 10, 20 and 40) and incubated for 24 h; (<bold>H</bold>
) RAW264.7 cells were infected with <italic>M. bovis</italic>
N strain at a MOI of 10 and incubated for indicated time periods, i.e., 0, 6, 12, 18 and 24 h; (<bold>I</bold>
) BMDMs were infected with <italic>M. bovis</italic>
N strain at a variable multiplicity of infection (MOI) (5, 10, 20 and 40) and incubated for 24 h; (<bold>J</bold>
) BMDMs were infected with <italic>M. bovis</italic>
N strain at a MOI of 10 and incubated for indicated time periods, i.e., 0, 6, 12, 18 and 24 h. In all these groups, KLK12 expression was determined by qRT-PCR; (<bold>K</bold>
) BMDMs were infected with <italic>M. bovis</italic>
C68004 at a variable MOI (5, 10, 20 and 40) and incubated for 24 h; (<bold>L</bold>
) BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated time periods (0, 6, 12, 18 and 24 h); (<bold>M</bold>
) BMDMs were infected with the <italic>M. bovis</italic>
N strain at a variable MOI (5, 10, 20 and 40) and incubated for 24 h; (<bold>N</bold>
) BMDMs were infected with the <italic>M. bovis</italic>
N strain at a MOI of 10 and incubated for indicated time periods (0, 6, 12, 18 and 24 h). KLK12 expression in these groups (K, L, M and N) was determined by the Western Blot analysis. The data showing in vitro expression of KLK12 represent the mean ± SD of three independent experiments (* <italic>p</italic>
< 0.05; ** <italic>p</italic>
< 0.01; *** <italic>p</italic>
< 0.001).</p>
</caption>
<graphic xlink:href="cells-08-00415-g001"></graphic>
</fig>
<fig id="cells-08-00415-f002" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p><italic>Mycobacterium bovis</italic>
C68004 (<italic>M. bovis</italic>
) infection induces autophagy in murine bone marrow derived macrophages (BMDMs) in a dose- (MOI) and time-dependent manner. (<bold>A</bold>
) Murine BMDMs were infected with <italic>M. bovis</italic>
C68004 at a variable MOI (5, 10, 20 and 40) and incubated for indicated time period. Expression of autophagic markers like LC3 II, Beclin-1 and β-Catenin was determined by the Western Blot analysis in infected and un-infected control BMDMs; (<bold>B</bold>
) murine BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated time periods (0, 6, 12, 18, 24 h). Expression of autophagic markers was determined by the Western Blot analysis and expression levels of various proteins were normalized to β-Actin. Data represent the mean ± SD of three independent experiments (** <italic>p</italic>
< 0.01; *** <italic>p</italic>
< 0.001).</p>
</caption>
<graphic xlink:href="cells-08-00415-g002"></graphic>
</fig>
<fig id="cells-08-00415-f003" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Knockdown of KLK12 impairs autophagy induction in <italic>M. bovis</italic>
C68004 infected murine BMDMs. (<bold>A</bold>
) Murine BMDMs were transfected with three different KLK12 siRNAs, having variable silencing targets, and a negative control siRNA (20 μM). After 48 h of transfection, KLK12 expression was determined by the Western Blot analysis. KLK12 expression was normalized to β-Actin expression; (<bold>B</bold>
) murine BMDMs were transfected as stated above and after 48 h of transfection KLK12 expression was determined by qRT-PCR; (<bold>C</bold>
) after 48 h of transfection, murine BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for 6 or 24 h. Expression of autophagic markers LC3 II, Beclin-1, p62 and β-Catenin was determined in KLK12 siRNA and negative control siRNA transfected BMDMs by the Western Blot analysis. Expression of all the proteins was normalized to β-Actin expression; (<bold>D</bold>
) murine macrophages were transfected as stated above and after 48 h of transfection, macrophages were treated with rapamycin (5 µm) for three h and then infected with <italic>M. bovis</italic>
C68004 (MOI 10). After 24 h of infection, LC3 II expression was determined by WB; (<bold>E</bold>
) murine macrophages were transfected as stated above and after 48 h, macrophages were treated with bafilomycin A1 (100 nm) for three h and then infected with <italic>M. bovis</italic>
C68004 (MOI 10). After 24 h of infection, LC3 II expression was determined. Data represent the mean ± SD of three independent experiments (* <italic>p</italic>
< 0.05; ** <italic>p</italic>
< 0.01; *** <italic>p</italic>
< 0.001).</p>
</caption>
<graphic xlink:href="cells-08-00415-g003"></graphic>
</fig>
<fig id="cells-08-00415-f004" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>KLK12 mediated regulation of autophagy in <italic>M. bovis</italic>
C68004 infected murine BMDMs implicates AMPK/TSC2/mTOR signaling pathway. Murine BMDMs were transfected with KLK12 siRNA and negative control siRNA (20uM). After 48 h of transfection, murine BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated time periods (6 and 24 h). Then, expression of phosphorylated AMPK, TSC2 and mTOR was determined in KLK12 siRNA and negative control siRNA transfected BMDMs by the Western Blot analysis. Expression of all the proteins was normalized to β-Actin expression. Data represent the mean ± SD of three independent experiments (* <italic>p</italic>
< 0.05; ** <italic>p</italic>
< 0.01).</p>
</caption>
<graphic xlink:href="cells-08-00415-g004"></graphic>
</fig>
<fig id="cells-08-00415-f005" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>KLK12 regulates apoptosis in <italic>M. bovis</italic>
C68004 infected murine BMDMs. (<bold>A</bold>
) Murine BMDMs were transfected with KLK12 siRNA and negative control siRNA (20 μM). After 48 h of transfection, murine BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated time periods (6 and 24 h). Number of apoptotic cells was determined by Annexin V FITC and propidium iodide (AV and PI) staining according to the manufacturer’s instructions. Binding of Annexin V and PI was analyzed by the BD FACS Calibur flow cytometry (BD Biosciences, San Jose, CA, USA); (<bold>B</bold>
) murine BMDMs were transfected with KLK12 siRNA and negative control siRNA and infected with <italic>M. bovis</italic>
C68004 as stated above. After the indicated time periods (6 and 24 h), translocation of BAX to mitochondria and release of Cytochrome c were determined by the Western Blot analysis by using Tubulin-α and TOM20 as loading controls for cytosolic and mitochondrial compartments, respectively; (<bold>C</bold>
) murine BMDMs were transfected with KLK12 siRNA and negative control siRNA and infected with <italic>M. bovis</italic>
C68004. After 6 and 24 h Caspase 3 and Bcl-2 expression levels were determined by the Western Blot analysis. Expression of all the proteins was normalized to β-Actin expression. Data represent the mean ± SD of three independent experiments (* <italic>p</italic>
< 0.05; ** <italic>p</italic>
< 0.01). Abbreviation used: T = total; C = cytoplasmic; M = mitochondrial.</p>
</caption>
<graphic xlink:href="cells-08-00415-g005"></graphic>
</fig>
<fig id="cells-08-00415-f006" orientation="portrait" position="float"><label>Figure 6</label>
<caption><p>KLK12 regulates cytokines expression in the <italic>M. bovis</italic>
C68004 infected murine BMDMs. (<bold>A</bold>
,<bold>B</bold>
) Murine BMDMs were transfected with KLK12 siRNA and negative control siRNA (20 uM). After 48 h of transfection, murine BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for 6 (<bold>A</bold>
) and 24 h (<bold>B</bold>
); expression of IL-1β, IL-6, IL-12, TNF-α, IL-10 and IFN-β was determined by qRT-PCR and β-Actin was taken as internal control; (<bold>C</bold>
,<bold>D</bold>
) murine BMDMs were transfected with KLK12 siRNA and negative control siRNA and infected with <italic>M. bovis</italic>
C68004 as stated above. Then, expression of IL-12, IL-10 and IFN-β were measured in cell supernatants by using ELISA kit after 6 (<bold>C</bold>
) and 24 h (<bold>D</bold>
) of incubation. Data represent the mean ± SD of three independent experiments (* <italic>p</italic>
< 0.05; ** <italic>p</italic>
< 0.01; ns, non-significant).</p>
</caption>
<graphic xlink:href="cells-08-00415-g006"></graphic>
</fig>
<fig id="cells-08-00415-f007" orientation="portrait" position="float"><label>Figure 7</label>
<caption><p>KLK12 restrains intracellular survival of <italic>M. bovis</italic>
in murine BMDMs. Murine BMDMs were transfected with KLK12 siRNA and negative control siRNA (20 μM). After 48 h of transfection, the BMDMs were infected with <italic>M. bovis</italic>
C68004 at a MOI of 10 and incubated for indicated times (6 and 24 h) and bacterial survival was measured by the CFU assay. Data represent the mean ± SD of three independent experiments (** <italic>p</italic>
< 0.01).</p>
</caption>
<graphic xlink:href="cells-08-00415-g007"></graphic>
</fig>
<table-wrap id="cells-08-00415-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">cells-08-00415-t001_Table 1</object-id>
<label>Table 1</label>
<caption><p>Primers used in the present study.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Gene Name</th>
<th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Forward Primer (5′-3′)</th>
<th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Reverse Primer (5′-3′)</th>
</tr>
</thead>
<tbody><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B-Actin</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-TGTTACCAACTGGGACGACA-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-ACCTGGGTCATCTTTTCACG-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>KLK12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-CAGCCAGACTCTCTGGTTCC-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-TCCAGCCCCTAGCTAACAGA-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>IL-1β</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-AAGGAGAACCAAGCAACGACAAAATA-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-TTTCCATCTTCTTCTTTGGGTATTGC-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>IL-6</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-CCCAATTTCCAATGCTCTCCTA-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-AGGAATGTCCACAAACTGATATGCT-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>IL-10</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-AGCATTTGAATTCCCTGGGTGA-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-CCTGCTCCACTGCCTTGCTCTT-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>IL-12</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-CCAAATTACTCCGGACGGTTCAC-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-CAGACAGAGACGCCATTCCACAT-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>TNF-α</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-AGAGCTACAAGAGGATCACCAGCAG-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-TCAGATTTACGGGTCAACTTCACAT-3</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>IFN-β</italic>
</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-AAGAGTTACACTGCCTTTGCCATC-3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-CACTGTCTGCTGGTGGAGTTCATC-3</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000472 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000472 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:6562459 |texte= Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:31060300" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
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