Periodontitis and Rheumatoid Arthritis in sub-Saharan Africa, gaps and way forward: a systematic review and meta-analysis.
Identifieur interne : 000385 ( Pmc/Curation ); précédent : 000384; suivant : 000386Periodontitis and Rheumatoid Arthritis in sub-Saharan Africa, gaps and way forward: a systematic review and meta-analysis.
Auteurs : William Buwembo ; Ian Guyton Munabi ; Mark Kaddumukasa ; Haruna Kiryowa ; Ethel Nankya [États-Unis] ; William Evan Johnson [États-Unis] ; Emmy Okello ; Nelson SewankamboSource :
- Open journal of stomatology [ 2160-8709 ] ; 2019.
Abstract
This review identified papers that described periodontitis and rheumatoid arthritis in sub-Saharan Africa. Only English language publications from January 2010 to December 2017 describing original research in sub-Saharan Africa on the association between periodontitis and rheumatoid arthritis were considered for this study.
Published databases: PubMed, Science direct and Google scholar, were searched using terms “periodontitis”, “rheumatoid arthritis” and “Sub-Saharan Africa” to generate a set of putative studies. Articles with data on both rheumatoid arthritis and periodontitis compared to controls were selected. Studies on the association of periodontitis with cardiovascular disease, arthritis or rheumatoid arthritis alone were excluded. Data were extracted, critically appraised, and analyzed using a random-effect Mantel–Haenszel meta-analysis on plaque index, gingival index, pocket depth and clinical attachment loss.
Three publications were selected for the systematic review and 2 for the meta-analysis. Two studies were from Sudan, and one was from Burina Faso. There was a significant increase in pocket depth (mean difference: 0.31; 95% CI: 0.21, 0.41; N= 274; (p ≤ 0.001) and clinical attachment loss (mean difference: 0.47; 95% CI: 0.22, 0.75; N= 274; (p ≤ 0.001) in participants with rheumatoid arthritis compared to normal controls.
Findings from these combined studies show a significant relationship between periodontal disease and rheumatoid arthritis with increased periodontal pocket depth and clinical attachment loss. They also highlight the need for additional work especially in the area of associating rheumatoid arthritis with
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DOI: 10.4236/ojst.2019.910023
PubMed: 31695961
PubMed Central: 6834353
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William Buwembo<affiliation><nlm:aff id="A1">Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation><affiliation><nlm:aff id="A1">Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation><affiliation><nlm:aff id="A1">Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation>Le document en format XML
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University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author><author><name sortKey="Sewankambo, Nelson" sort="Sewankambo, Nelson" uniqKey="Sewankambo N" first="Nelson" last="Sewankambo">Nelson Sewankambo</name><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31695961</idno><idno type="pmc">6834353</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834353</idno><idno type="RBID">PMC:6834353</idno><idno type="doi">10.4236/ojst.2019.910023</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000385</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" 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Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author><author><name sortKey="Kaddumukasa, Mark" sort="Kaddumukasa, Mark" uniqKey="Kaddumukasa M" first="Mark" last="Kaddumukasa">Mark Kaddumukasa</name><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author><author><name sortKey="Kiryowa, Haruna" sort="Kiryowa, Haruna" uniqKey="Kiryowa H" first="Haruna" last="Kiryowa">Haruna Kiryowa</name><affiliation><nlm:aff id="A1">Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author><author><name sortKey="Nankya, Ethel" sort="Nankya, Ethel" uniqKey="Nankya E" first="Ethel" last="Nankya">Ethel Nankya</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University</wicri:regionArea></affiliation></author><author><name sortKey="Johnson, William Evan" sort="Johnson, William Evan" uniqKey="Johnson W" first="William Evan" last="Johnson">William Evan Johnson</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University</wicri:regionArea></affiliation></author><author><name sortKey="Okello, Emmy" sort="Okello, Emmy" uniqKey="Okello E" first="Emmy" last="Okello">Emmy Okello</name><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author><author><name sortKey="Sewankambo, Nelson" sort="Sewankambo, Nelson" uniqKey="Sewankambo N" first="Nelson" last="Sewankambo">Nelson Sewankambo</name><affiliation><nlm:aff id="A2">Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</nlm:aff><wicri:noCountry code="subfield">Kampala Uganda</wicri:noCountry></affiliation></author></analytic><series><title level="j">Open journal of stomatology</title><idno type="ISSN">2160-8709</idno><idno type="eISSN">2160-8717</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background:</title><p id="P4">This review identified papers that described periodontitis and rheumatoid arthritis in sub-Saharan Africa. Only English language publications from January 2010 to December 2017 describing original research in sub-Saharan Africa on the association between periodontitis and rheumatoid arthritis were considered for this study.</p></sec><sec id="S2"><title>Methods:</title><p id="P5">Published databases: PubMed, Science direct and Google scholar, were searched using terms “periodontitis”, “rheumatoid arthritis” and “Sub-Saharan Africa” to generate a set of putative studies. Articles with data on both rheumatoid arthritis and periodontitis compared to controls were selected. Studies on the association of periodontitis with cardiovascular disease, arthritis or rheumatoid arthritis alone were excluded. Data were extracted, critically appraised, and analyzed using a random-effect Mantel–Haenszel meta-analysis on plaque index, gingival index, pocket depth and clinical attachment loss.</p></sec><sec id="S3"><title>Results:</title><p id="P6">Three publications were selected for the systematic review and 2 for the meta-analysis. Two studies were from Sudan, and one was from Burina Faso. There was a significant increase in pocket depth (mean difference: 0.31; 95% CI: 0.21, 0.41; N= 274; (p ≤ 0.001) and clinical attachment loss (mean difference: 0.47; 95% CI: 0.22, 0.75; N= 274; (p ≤ 0.001) in participants with rheumatoid arthritis compared to normal controls.</p></sec><sec id="S4"><title>Conclusion:</title><p id="P7">Findings from these combined studies show a significant relationship between periodontal disease and rheumatoid arthritis with increased periodontal pocket depth and clinical attachment loss. They also highlight the need for additional work especially in the area of associating rheumatoid arthritis with <italic>P. gingivalis,</italic> the oral microbiome and treating periodontal diseases to help in the management of rheumatoid arthritis.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101603435</journal-id><journal-id journal-id-type="pubmed-jr-id">49001</journal-id><journal-id journal-id-type="nlm-ta">Open J Stomatol</journal-id><journal-id journal-id-type="iso-abbrev">Open J Stomatol</journal-id><journal-title-group><journal-title>Open journal of stomatology</journal-title></journal-title-group><issn pub-type="ppub">2160-8709</issn><issn pub-type="epub">2160-8717</issn></journal-meta><article-meta><article-id pub-id-type="pmid">31695961</article-id><article-id pub-id-type="pmc">6834353</article-id><article-id pub-id-type="doi">10.4236/ojst.2019.910023</article-id><article-id pub-id-type="manuscript">NIHMS1055327</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Periodontitis and Rheumatoid Arthritis in sub-Saharan Africa, gaps and way forward: a systematic review and meta-analysis.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Buwembo</surname><given-names>William</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref><xref rid="CR1" ref-type="corresp">§</xref></contrib><contrib contrib-type="author"><name><surname>Munabi</surname><given-names>Ian Guyton</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Kaddumukasa</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kiryowa</surname><given-names>Haruna</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nankya</surname><given-names>Ethel</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>William Evan</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Okello</surname><given-names>Emmy</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sewankambo</surname><given-names>Nelson</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Human Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala Uganda</aff><aff id="A2"><label>2</label>Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala Uganda</aff><aff id="A3"><label>3</label>Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA, Boston University, USA</aff><author-notes><fn id="FN1"><label>*</label><p id="P1">These authors contributed equally to this work</p></fn><corresp id="CR1"><label>§</label> Corresponding author WB: <email>wbuwembo@yahoo.com</email></corresp><fn fn-type="con" id="FN2"><p id="P2">Authours’ contributions</p><p id="P3">EO conceived the initial research idea and was a major contributor to the manuscript. WB, IGM and KM refined the research idea, drafted the initial proposal, and were involved in the whole research process till drafting of the manuscript. WEJ and NS were instrumental in refining the research methodology, contributed to the drafting of the manuscript and were involved in <underline>analyzing</underline> the data for meta-analysis. HK and EN contributed to data extraction for the systemic review and critically read the draft manuscript. All co-authors reviewed the final manuscript prior to submission.</p></fn><fn fn-type="COI-statement" id="FN3"><p id="P28">Conflicts of Interest</p><p id="P29">The authors declare that they have no competing interests.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>10</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>10</day><month>10</month><year>2019</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>06</day><month>11</month><year>2019</year></pub-date><volume>9</volume><issue>10</issue><fpage>215</fpage><lpage>226</lpage><pmc-comment>elocation-id from pubmed: 10.4236/ojst.2019.910023</pmc-comment>
<self-uri xlink:href="https://www.scirp.org/journal/paperinformation.aspx?paperid=95591"></self-uri><abstract id="ABS1"><sec id="S1"><title>Background:</title><p id="P4">This review identified papers that described periodontitis and rheumatoid arthritis in sub-Saharan Africa. Only English language publications from January 2010 to December 2017 describing original research in sub-Saharan Africa on the association between periodontitis and rheumatoid arthritis were considered for this study.</p></sec><sec id="S2"><title>Methods:</title><p id="P5">Published databases: PubMed, Science direct and Google scholar, were searched using terms “periodontitis”, “rheumatoid arthritis” and “Sub-Saharan Africa” to generate a set of putative studies. Articles with data on both rheumatoid arthritis and periodontitis compared to controls were selected. Studies on the association of periodontitis with cardiovascular disease, arthritis or rheumatoid arthritis alone were excluded. Data were extracted, critically appraised, and analyzed using a random-effect Mantel–Haenszel meta-analysis on plaque index, gingival index, pocket depth and clinical attachment loss.</p></sec><sec id="S3"><title>Results:</title><p id="P6">Three publications were selected for the systematic review and 2 for the meta-analysis. Two studies were from Sudan, and one was from Burina Faso. There was a significant increase in pocket depth (mean difference: 0.31; 95% CI: 0.21, 0.41; N= 274; (p ≤ 0.001) and clinical attachment loss (mean difference: 0.47; 95% CI: 0.22, 0.75; N= 274; (p ≤ 0.001) in participants with rheumatoid arthritis compared to normal controls.</p></sec><sec id="S4"><title>Conclusion:</title><p id="P7">Findings from these combined studies show a significant relationship between periodontal disease and rheumatoid arthritis with increased periodontal pocket depth and clinical attachment loss. They also highlight the need for additional work especially in the area of associating rheumatoid arthritis with <italic>P. gingivalis,</italic> the oral microbiome and treating periodontal diseases to help in the management of rheumatoid arthritis.</p></sec></abstract><kwd-group><kwd>Periodontitis</kwd><kwd>Rheumatoid arthritis</kwd><kwd>sub-Saharan Africa</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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