Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
Identifieur interne : 000233 ( Pmc/Curation ); précédent : 000232; suivant : 000234Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
Auteurs : Mara Cirone [Italie] ; Maria Saveria Gilardini Montani [Italie] ; Marisa Granato [Italie] ; Alessia Garufi [Italie] ; Alberto Faggioni [Italie] ; Gabriella D Razi [Italie]Source :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2019.
Abstract
Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies.
Url:
DOI: 10.1186/s13046-019-1275-z
PubMed: 31200739
PubMed Central: 6570888
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Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name></author><author><name sortKey="Abdelmohsen, K" uniqKey="Abdelmohsen K">K Abdelmohsen</name></author><author><name sortKey="Abe, A" uniqKey="Abe A">A Abe</name></author><author><name sortKey="Abedin, Mj" uniqKey="Abedin M">MJ Abedin</name></author><author><name sortKey="Abeliovich, H" uniqKey="Abeliovich H">H Abeliovich</name></author><author><name sortKey="Acevedo Arozena, A" uniqKey="Acevedo Arozena A">A Acevedo Arozena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yun, Cw" uniqKey="Yun C">CW 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Clin Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">J. Exp. Clin. Cancer Res</journal-id><journal-title-group><journal-title>Journal of Experimental & Clinical Cancer Research : CR</journal-title></journal-title-group><issn pub-type="ppub">0392-9078</issn><issn pub-type="epub">1756-9966</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31200739</article-id><article-id pub-id-type="pmc">6570888</article-id><article-id pub-id-type="publisher-id">1275</article-id><article-id pub-id-type="doi">10.1186/s13046-019-1275-z</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Cirone</surname><given-names>Mara</given-names></name><address><email>mara.cirone@uniroma1.it</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gilardini Montani</surname><given-names>Maria Saveria</given-names></name><address><email>mariasaveria.gilardinimontani@uniroma1.it</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Granato</surname><given-names>Marisa</given-names></name><address><email>marisa.granato@uniroma1.it</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Garufi</surname><given-names>Alessia</given-names></name><address><email>alessiagarufi@yahoo.it</email></address><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Faggioni</surname><given-names>Alberto</given-names></name><address><email>alberto.faggioni@uniroma1.it</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-6876-9105</contrib-id><name><surname>D’Orazi</surname><given-names>Gabriella</given-names></name><address><email>gdorazi@unich.it</email></address><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.7841.a</institution-id><institution>Department of Experimental Medicine,</institution><institution>“Sapienza” University of Rome,</institution></institution-wrap>Rome, Italy</aff><aff id="Aff2"><label>2</label>Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2181 4941</institution-id><institution-id institution-id-type="GRID">grid.412451.7</institution-id><institution>Department of Medical Science,</institution><institution>University ‘G. D’Annunzio’,</institution></institution-wrap>66013 Chieti, Italy</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1760 5276</institution-id><institution-id institution-id-type="GRID">grid.417520.5</institution-id><institution>Department of Research,</institution><institution>IRCCS Regina Elena National Cancer Institute,</institution></institution-wrap>00144 Rome, Italy</aff></contrib-group><pub-date pub-type="epub"><day>14</day><month>6</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>6</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>38</volume><elocation-id>262</elocation-id><history><date date-type="received"><day>30</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2019</year></date></history><permissions><copyright-statement>© The Author(s). 2019</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Autophagy</kwd><kwd>Cancer</kwd><kwd>Immunogenic cell death (ICD)</kwd><kwd>Endoplasmic reticulum (ER stress)</kwd><kwd>Unfolded protein response (UPR)</kwd><kwd>Chloroquine (CQ)</kwd><kwd>Hydroxichloroquine (HCQ)</kwd><kwd>p53</kwd><kwd>HSF1</kwd><kwd>NRF2</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100005010</institution-id><institution>Associazione Italiana per la Ricerca sul Cancro</institution></institution-wrap></funding-source><award-id>IG2015, 16742</award-id></award-group></funding-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100004588</institution-id><institution>Istituto Pasteur-Fondazione Cenci Bolognetti</institution></institution-wrap></funding-source><award-id>n. C26A</award-id><principal-award-recipient><name><surname>Cirone</surname><given-names>Mara</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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