Wide field retinal imaging and the detection of drug associated retinal toxicity
Identifieur interne : 000227 ( Pmc/Curation ); précédent : 000226; suivant : 000228Wide field retinal imaging and the detection of drug associated retinal toxicity
Auteurs : Giulia Corradetti [États-Unis] ; Sara Violanti [États-Unis] ; Adrian Au [États-Unis] ; David Sarraf [États-Unis]Source :
- International Journal of Retina and Vitreous [ 2056-9920 ] ; 2019.
Abstract
To describe the peripheral retinal findings associated with systemic medication toxicity and to outline the importance of ultra-widefield imaging in the detection, analysis and monitoring of these abnormalities.
This review highlights the retinal manifestations associated with the more common drug toxicities, with emphasis on the peripheral features and the indications for wide field imaging. The presenting findings, underlying pathophysiology, and retinal alterations in hydroxychloroquine, thioridazine, didanosine, tamoxifen, MEK-inhibitor, and immune checkpoint inhibitor associated drug toxicity will be described and the importance of wide field imaging in the evaluation of these abnormalities will be emphasized.
Wide field retinal imaging can improve the detection of peripheral retinal abnormalities associated with drug toxicity and may be an important tool in the diagnosis and management of these disorders.
Url:
DOI: 10.1186/s40942-019-0172-0
PubMed: 31890286
PubMed Central: 6907121
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xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>100 Stein Plaza, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Violanti, Sara" sort="Violanti, Sara" uniqKey="Violanti S" first="Sara" last="Violanti">Sara Violanti</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9632 6718</institution-id><institution-id institution-id-type="GRID">grid.19006.3e</institution-id><institution>Retina Disorders and Ophthalmic Genetics, Stein Eye Institute,</institution><institution>University of California, Los Angeles,</institution></institution-wrap>100 Stein Plaza, Los Angeles, CA 90095 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>100 Stein Plaza, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Au, Adrian" sort="Au, Adrian" uniqKey="Au A" first="Adrian" last="Au">Adrian Au</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9632 6718</institution-id><institution-id institution-id-type="GRID">grid.19006.3e</institution-id><institution>Retina Disorders and Ophthalmic Genetics, Stein Eye Institute,</institution><institution>University of California, Los Angeles,</institution></institution-wrap>100 Stein Plaza, Los Angeles, CA 90095 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>100 Stein Plaza, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Sarraf, David" sort="Sarraf, David" uniqKey="Sarraf D" first="David" last="Sarraf">David Sarraf</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9632 6718</institution-id><institution-id institution-id-type="GRID">grid.19006.3e</institution-id><institution>Retina Disorders and Ophthalmic Genetics, Stein Eye Institute,</institution><institution>University of California, Los Angeles,</institution></institution-wrap>100 Stein Plaza, Los Angeles, CA 90095 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>100 Stein Plaza, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2">Greater Los Angeles VA Healthcare Center, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Greater Los Angeles VA Healthcare Center, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">International Journal of Retina and Vitreous</title><idno type="eISSN">2056-9920</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">To describe the peripheral retinal findings associated with systemic medication toxicity and to outline the importance of ultra-widefield imaging in the detection, analysis and monitoring of these abnormalities.</p></sec><sec><title>Main text</title><p id="Par2">This review highlights the retinal manifestations associated with the more common drug toxicities, with emphasis on the peripheral features and the indications for wide field imaging. The presenting findings, underlying pathophysiology, and retinal alterations in hydroxychloroquine, thioridazine, didanosine, tamoxifen, MEK-inhibitor, and immune checkpoint inhibitor associated drug toxicity will be described and the importance of wide field imaging in the evaluation of these abnormalities will be emphasized.</p></sec><sec><title>Conclusions</title><p id="Par3">Wide field retinal imaging can improve the detection of peripheral retinal abnormalities associated with drug toxicity and may be an important tool in the diagnosis and management of these disorders.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ben Zvi, I" uniqKey="Ben Zvi I">I Ben-Zvi</name></author><author><name sortKey="Kivity, S" uniqKey="Kivity S">S Kivity</name></author><author><name sortKey="Langevitz, P" uniqKey="Langevitz P">P Langevitz</name></author><author><name sortKey="Shoenfeld, Y" uniqKey="Shoenfeld Y">Y 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Retina Vitreous</journal-id><journal-id journal-id-type="iso-abbrev">Int J Retina Vitreous</journal-id><journal-title-group><journal-title>International Journal of Retina and Vitreous</journal-title></journal-title-group><issn pub-type="epub">2056-9920</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31890286</article-id><article-id pub-id-type="pmc">6907121</article-id><article-id pub-id-type="publisher-id">172</article-id><article-id pub-id-type="doi">10.1186/s40942-019-0172-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Wide field retinal imaging and the detection of drug associated retinal toxicity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Corradetti</surname><given-names>Giulia</given-names></name><address><email>giulia.corradetti@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Violanti</surname><given-names>Sara</given-names></name><address><email>sara.violanti@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Au</surname><given-names>Adrian</given-names></name><address><email>au@jsei.ucla.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Sarraf</surname><given-names>David</given-names></name><address><email>dsarraf@ucla.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9632 6718</institution-id><institution-id institution-id-type="GRID">grid.19006.3e</institution-id><institution>Retina Disorders and Ophthalmic Genetics, Stein Eye Institute,</institution><institution>University of California, Los Angeles,</institution></institution-wrap>100 Stein Plaza, Los Angeles, CA 90095 USA</aff><aff id="Aff2"><label>2</label>Greater Los Angeles VA Healthcare Center, Los Angeles, CA USA</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>5</volume><issue>Suppl 1</issue><issue-sponsor>The publication costs for this supplement were made possible with unconditional financial support from Optos. The sponsor had no input into the content of articles, which were independently prepared by the authors and have undergone the journal’s standard peer-review process.</issue-sponsor><elocation-id>26</elocation-id><permissions><copyright-statement>© The Author(s) 2019</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">To describe the peripheral retinal findings associated with systemic medication toxicity and to outline the importance of ultra-widefield imaging in the detection, analysis and monitoring of these abnormalities.</p></sec><sec><title>Main text</title><p id="Par2">This review highlights the retinal manifestations associated with the more common drug toxicities, with emphasis on the peripheral features and the indications for wide field imaging. The presenting findings, underlying pathophysiology, and retinal alterations in hydroxychloroquine, thioridazine, didanosine, tamoxifen, MEK-inhibitor, and immune checkpoint inhibitor associated drug toxicity will be described and the importance of wide field imaging in the evaluation of these abnormalities will be emphasized.</p></sec><sec><title>Conclusions</title><p id="Par3">Wide field retinal imaging can improve the detection of peripheral retinal abnormalities associated with drug toxicity and may be an important tool in the diagnosis and management of these disorders.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Drug toxicity</kwd><kwd>Periphery</kwd><kwd>Ultra-widefield</kwd></kwd-group><funding-group><award-group><funding-source><institution>Optos, Inc</institution></funding-source></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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