Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine
Identifieur interne : 000225 ( Pmc/Curation ); précédent : 000224; suivant : 000226Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine
Auteurs : Hua Luo [République populaire de Chine] ; Chi Teng Vong [République populaire de Chine] ; Hanbin Chen [République populaire de Chine] ; Yan Gao [République populaire de Chine] ; Peng Lyu [République populaire de Chine] ; Ling Qiu [République populaire de Chine] ; Mingming Zhao [République populaire de Chine] ; Qiao Liu [République populaire de Chine] ; Zehua Cheng [République populaire de Chine] ; Jian Zou [République populaire de Chine] ; Peifen Yao [République populaire de Chine] ; Caifang Gao [République populaire de Chine] ; Jinchao Wei [République populaire de Chine] ; Carolina Oi Lam Ung [République populaire de Chine] ; Shengpeng Wang [République populaire de Chine] ; Zhangfeng Zhong [République populaire de Chine] ; Yitao Wang [République populaire de Chine]Source :
- Chinese Medicine [ 1749-8546 ] ; 2019.
Abstract
Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.
Url:
DOI: 10.1186/s13020-019-0270-9
PubMed: 31719837
PubMed Central: 6836491
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<front><div type="abstract" xml:lang="en"><p id="Par1">Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.</p>
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</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chin Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Chin Med</journal-id>
<journal-title-group><journal-title>Chinese Medicine</journal-title>
</journal-title-group>
<issn pub-type="epub">1749-8546</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31719837</article-id>
<article-id pub-id-type="pmc">6836491</article-id>
<article-id pub-id-type="publisher-id">270</article-id>
<article-id pub-id-type="doi">10.1186/s13020-019-0270-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Luo</surname>
<given-names>Hua</given-names>
</name>
<address><email>yb87518@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Vong</surname>
<given-names>Chi Teng</given-names>
</name>
<address><email>gigictvong@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Hanbin</given-names>
</name>
<address><email>yb87511@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Yan</given-names>
</name>
<address><email>gaoyanki@hotmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lyu</surname>
<given-names>Peng</given-names>
</name>
<address><email>yb87503@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qiu</surname>
<given-names>Ling</given-names>
</name>
<address><email>yb87510@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Mingming</given-names>
</name>
<address><email>yb87509@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Qiao</given-names>
</name>
<address><email>yb87502@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheng</surname>
<given-names>Zehua</given-names>
</name>
<address><email>yb87516@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zou</surname>
<given-names>Jian</given-names>
</name>
<address><email>yb87505@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yao</surname>
<given-names>Peifen</given-names>
</name>
<address><email>yb87508@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Caifang</given-names>
</name>
<address><email>yb87504@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wei</surname>
<given-names>Jinchao</given-names>
</name>
<address><email>wjc551@hotmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ung</surname>
<given-names>Carolina Oi Lam</given-names>
</name>
<address><email>carolinaung@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Shengpeng</given-names>
</name>
<address><email>swang@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Zhong</surname>
<given-names>Zhangfeng</given-names>
</name>
<address><email>zfzhong@aliyun.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname>
<given-names>Yitao</given-names>
</name>
<address><email>ytwang@um.edu.mo</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1">Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>6</day>
<month>11</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>6</day>
<month>11</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>14</volume>
<elocation-id>48</elocation-id>
<history><date date-type="received"><day>20</day>
<month>8</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>23</day>
<month>10</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Cancer</kwd>
<kwd>Chinese herbal medicine</kwd>
<kwd>Natural products</kwd>
<kwd>Bioactive compounds</kwd>
<kwd>Traditional Chinese medicine</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution>the Macao Science and Technology Development Fund</institution>
</funding-source>
<award-id>FDCT 071/2017/A2</award-id>
<principal-award-recipient><name><surname>Wang</surname>
<given-names>Yitao</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution>the Research Committee of the University of Macau</institution>
</funding-source>
<award-id>CPG2019-00006-ICMS</award-id>
<principal-award-recipient><name><surname>Wang</surname>
<given-names>Yitao</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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