Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm
Identifieur interne : 000189 ( Pmc/Curation ); précédent : 000188; suivant : 000190Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm
Auteurs : Lili Pan [République populaire de Chine] ; Juan Du [République populaire de Chine] ; Dong Chen [République populaire de Chine] ; Yanli Zhao [République populaire de Chine] ; Xi Guo [République populaire de Chine] ; Guanming Qi [États-Unis] ; Tian Wang [République populaire de Chine] ; Jie Du [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Low-density lipoprotein cholesterol (LDL-C) has been associated with the occurrence of abdominal aortic aneurysm. However, whether LDL-C elevation associated with aneurysms in large vessel vasculitis is unknown. The aim of this study is to investigate the clinical and laboratory features of Takayasu arteritis (TAK) and explore the risk factors that associated with aneurysm in these patients. This retrospective study compared the clinical manifestations, laboratory parameters, and imaging results of 103 TAK patients with or without aneurysms and analyzed the risk factors of aneurysm formation. 20.4% of TAK patients were found to have aneurysms. The LDL-C levels was higher in the aneurysm group than in the non-aneurysm group (2.9 ± 0.9 mmol/l vs. 2.4 ± 0.9 mmol/l, p = 0.032). Elevated serum LDL-C levels increased the risk of aneurysm by 5.8-fold (p = 0.021, odds ratio [OR] = 5.767, 95% confidence interval [CI]: 1.302–25.543), and the cutoff value of level of serum LDL-C was 3.08 mmol/l. The risk of aneurysm was 4.2-fold higher in patients with disease duration >5 years (p = 0.042, OR = 4.237, 95% CI: 1.055–17.023), and 2.9-fold higher when an elevated erythrocyte sedimentation rate was present (p = 0.077, OR = 2.851, 95% CI: 0.891–9.115). In this study, elevated LDL-C levels increased the risk of developing aneurysms in patients with TAK.
Url:
DOI: 10.1038/s41598-019-50527-z
PubMed: 31575993
PubMed Central: 6773689
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000189
Links to Exploration step
PMC:6773689Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm</title>
<author><name sortKey="Pan, Lili" sort="Pan, Lili" uniqKey="Pan L" first="Lili" last="Pan">Lili Pan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Dong" sort="Chen, Dong" uniqKey="Chen D" first="Dong" last="Chen">Dong Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Pathology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Yanli" sort="Zhao, Yanli" uniqKey="Zhao Y" first="Yanli" last="Zhao">Yanli Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Pathology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Xi" sort="Guo, Xi" uniqKey="Guo X" first="Xi" last="Guo">Xi Guo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Interventional Radiology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Qi, Guanming" sort="Qi, Guanming" uniqKey="Qi G" first="Guanming" last="Qi">Guanming Qi</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Pulmonary and Critical Care Division,</institution>
<institution>Tufts Medical Center,</institution>
</institution-wrap>
Boston, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Tian" sort="Wang, Tian" uniqKey="Wang T" first="Tian" last="Wang">Tian Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Du, Jie" sort="Du, Jie" uniqKey="Du J" first="Jie" last="Du">Jie Du</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Beijing</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31575993</idno>
<idno type="pmc">6773689</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773689</idno>
<idno type="RBID">PMC:6773689</idno>
<idno type="doi">10.1038/s41598-019-50527-z</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000189</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000189</idno>
<idno type="wicri:Area/Pmc/Curation">000189</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000189</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm</title>
<author><name sortKey="Pan, Lili" sort="Pan, Lili" uniqKey="Pan L" first="Lili" last="Pan">Lili Pan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Dong" sort="Chen, Dong" uniqKey="Chen D" first="Dong" last="Chen">Dong Chen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Pathology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Yanli" sort="Zhao, Yanli" uniqKey="Zhao Y" first="Yanli" last="Zhao">Yanli Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Pathology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Xi" sort="Guo, Xi" uniqKey="Guo X" first="Xi" last="Guo">Xi Guo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Interventional Radiology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Qi, Guanming" sort="Qi, Guanming" uniqKey="Qi G" first="Guanming" last="Qi">Guanming Qi</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Pulmonary and Critical Care Division,</institution>
<institution>Tufts Medical Center,</institution>
</institution-wrap>
Boston, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Tian" sort="Wang, Tian" uniqKey="Wang T" first="Tian" last="Wang">Tian Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Du, Jie" sort="Du, Jie" uniqKey="Du J" first="Jie" last="Du">Jie Du</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Beijing</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific Reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">Low-density lipoprotein cholesterol (LDL-C) has been associated with the occurrence of abdominal aortic aneurysm. However, whether LDL-C elevation associated with aneurysms in large vessel vasculitis is unknown. The aim of this study is to investigate the clinical and laboratory features of Takayasu arteritis (TAK) and explore the risk factors that associated with aneurysm in these patients. This retrospective study compared the clinical manifestations, laboratory parameters, and imaging results of 103 TAK patients with or without aneurysms and analyzed the risk factors of aneurysm formation. 20.4% of TAK patients were found to have aneurysms. The LDL-C levels was higher in the aneurysm group than in the non-aneurysm group (2.9 ± 0.9 mmol/l vs. 2.4 ± 0.9 mmol/l, p = 0.032). Elevated serum LDL-C levels increased the risk of aneurysm by 5.8-fold (p = 0.021, odds ratio [OR] = 5.767, 95% confidence interval [CI]: 1.302–25.543), and the cutoff value of level of serum LDL-C was 3.08 mmol/l. The risk of aneurysm was 4.2-fold higher in patients with disease duration >5 years (p = 0.042, OR = 4.237, 95% CI: 1.055–17.023), and 2.9-fold higher when an elevated erythrocyte sedimentation rate was present (p = 0.077, OR = 2.851, 95% CI: 0.891–9.115). In this study, elevated LDL-C levels increased the risk of developing aneurysms in patients with TAK.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Robinson, D" uniqKey="Robinson D">D Robinson</name>
</author>
<author><name sortKey="Mees, B" uniqKey="Mees B">B Mees</name>
</author>
<author><name sortKey="Verhagen, H" uniqKey="Verhagen H">H Verhagen</name>
</author>
<author><name sortKey="Chuen, J" uniqKey="Chuen J">J Chuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ikeda, Y" uniqKey="Ikeda Y">Y Ikeda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Comarmond, C" uniqKey="Comarmond C">C Comarmond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maleszewski, Jj" uniqKey="Maleszewski J">JJ Maleszewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogino, H" uniqKey="Ogino H">H Ogino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Da Silva, Tf" uniqKey="Da Silva T">TF da Silva</name>
</author>
<author><name sortKey="Levy Neto, M" uniqKey="Levy Neto M">M Levy-Neto</name>
</author>
<author><name sortKey="Bonfa, E" uniqKey="Bonfa E">E Bonfa</name>
</author>
<author><name sortKey="Pereira, Rm" uniqKey="Pereira R">RM Pereira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Ay" uniqKey="Lim A">AY Lim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohigashi, H" uniqKey="Ohigashi H">H Ohigashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saadoun, D" uniqKey="Saadoun D">D Saadoun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Chen, B" uniqKey="Chen B">B Chen</name>
</author>
<author><name sortKey="Lv, N" uniqKey="Lv N">N Lv</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name>
</author>
<author><name sortKey="Dang, A" uniqKey="Dang A">A Dang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arend, Wp" uniqKey="Arend W">WP Arend</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kerr, Gs" uniqKey="Kerr G">GS Kerr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Misra, R" uniqKey="Misra R">R Misra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnston, Kw" uniqKey="Johnston K">KW Johnston</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hata, A" uniqKey="Hata A">A Hata</name>
</author>
<author><name sortKey="Noda, M" uniqKey="Noda M">M Noda</name>
</author>
<author><name sortKey="Moriwaki, R" uniqKey="Moriwaki R">R Moriwaki</name>
</author>
<author><name sortKey="Numano, F" uniqKey="Numano F">F Numano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hashizume, M" uniqKey="Hashizume M">M Hashizume</name>
</author>
<author><name sortKey="Mihara, M" uniqKey="Mihara M">M Mihara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaabane, C" uniqKey="Chaabane C">C Chaabane</name>
</author>
<author><name sortKey="Coen, M" uniqKey="Coen M">M Coen</name>
</author>
<author><name sortKey="Bochaton Piallat, Ml" uniqKey="Bochaton Piallat M">ML Bochaton-Piallat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lekic, A" uniqKey="Lekic A">A Lekic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishikawa, M" uniqKey="Ishikawa M">M Ishikawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De La Rocha, Jal" uniqKey="De La Rocha J">JAL de la Rocha</name>
</author>
<author><name sortKey="Espinoza, Lr" uniqKey="Espinoza L">LR Espinoza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arnaud, L" uniqKey="Arnaud L">L Arnaud</name>
</author>
<author><name sortKey="Haroche, J" uniqKey="Haroche J">J Haroche</name>
</author>
<author><name sortKey="Mathian, A" uniqKey="Mathian A">A Mathian</name>
</author>
<author><name sortKey="Gorochov, G" uniqKey="Gorochov G">G Gorochov</name>
</author>
<author><name sortKey="Amoura, Z" uniqKey="Amoura Z">Z Amoura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuyama, A" uniqKey="Matsuyama A">A Matsuyama</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id>
<journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id>
<journal-title-group><journal-title>Scientific Reports</journal-title>
</journal-title-group>
<issn pub-type="epub">2045-2322</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31575993</article-id>
<article-id pub-id-type="pmc">6773689</article-id>
<article-id pub-id-type="publisher-id">50527</article-id>
<article-id pub-id-type="doi">10.1038/s41598-019-50527-z</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Pan</surname>
<given-names>Lili</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Du</surname>
<given-names>Juan</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Dong</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Yanli</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guo</surname>
<given-names>Xi</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qi</surname>
<given-names>Guanming</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Tian</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Du</surname>
<given-names>Jie</given-names>
</name>
<address><email>jiedubj@126.com</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Rheumatology and Immunology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Pathology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0369 153X</institution-id>
<institution-id institution-id-type="GRID">grid.24696.3f</institution-id>
<institution>Department of Interventional Radiology, Beijing Anzhen Hospital,</institution>
<institution>Capital Medical University,</institution>
</institution-wrap>
Beijing, China</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8934 4045</institution-id>
<institution-id institution-id-type="GRID">grid.67033.31</institution-id>
<institution>Pulmonary and Critical Care Division,</institution>
<institution>Tufts Medical Center,</institution>
</institution-wrap>
Boston, MA USA</aff>
<aff id="Aff5"><label>5</label>
Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China</aff>
<aff id="Aff6"><label>6</label>
Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Center for Cardiovascular Disorders, Beijing, China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>1</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>9</volume>
<elocation-id>14083</elocation-id>
<history><date date-type="received"><day>13</day>
<month>5</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>23</day>
<month>8</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Low-density lipoprotein cholesterol (LDL-C) has been associated with the occurrence of abdominal aortic aneurysm. However, whether LDL-C elevation associated with aneurysms in large vessel vasculitis is unknown. The aim of this study is to investigate the clinical and laboratory features of Takayasu arteritis (TAK) and explore the risk factors that associated with aneurysm in these patients. This retrospective study compared the clinical manifestations, laboratory parameters, and imaging results of 103 TAK patients with or without aneurysms and analyzed the risk factors of aneurysm formation. 20.4% of TAK patients were found to have aneurysms. The LDL-C levels was higher in the aneurysm group than in the non-aneurysm group (2.9 ± 0.9 mmol/l vs. 2.4 ± 0.9 mmol/l, p = 0.032). Elevated serum LDL-C levels increased the risk of aneurysm by 5.8-fold (p = 0.021, odds ratio [OR] = 5.767, 95% confidence interval [CI]: 1.302–25.543), and the cutoff value of level of serum LDL-C was 3.08 mmol/l. The risk of aneurysm was 4.2-fold higher in patients with disease duration >5 years (p = 0.042, OR = 4.237, 95% CI: 1.055–17.023), and 2.9-fold higher when an elevated erythrocyte sedimentation rate was present (p = 0.077, OR = 2.851, 95% CI: 0.891–9.115). In this study, elevated LDL-C levels increased the risk of developing aneurysms in patients with TAK.</p>
</abstract>
<kwd-group kwd-group-type="npg-subject"><title>Subject terms</title>
<kwd>Vasculitis</kwd>
<kwd>Vasculitis</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000189 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000189 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:6773689 |texte= Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:31575993" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |