Pulsed-wave Ultrasound Hyperthermia Enhanced Nanodrug Delivery Combined with Chloroquine Exerts Effective Antitumor Response and Postpones Recurrence
Identifieur interne : 000185 ( Pmc/Curation ); précédent : 000184; suivant : 000186Pulsed-wave Ultrasound Hyperthermia Enhanced Nanodrug Delivery Combined with Chloroquine Exerts Effective Antitumor Response and Postpones Recurrence
Auteurs : Chi-Feng Chiang [Taïwan] ; Yu-Hone Hsu [Taïwan] ; Chih-Chun Liu [Taïwan] ; Po-Chin Liang [Taïwan] ; Shi-Chuen Miaw [Taïwan] ; Win-Li Lin [Taïwan]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Autophagy is found to serve as a surviving mechanism for cancer cells. Inhibiting autophagy has been considered as an adjuvant anti-cancer strategy. In this study, we investigated the anti-tumor effect of combining pulsed-wave ultrasound hyperthermia (pUH) enhanced PEGylated liposomal doxorubicin (PLD) delivery with an autophagy inhibitor chloroquine (CQ). BALB/c mice bearing subcutaneous 4T1 tumor received intravenous injection of PLD (10 mg/kg) plus 15-minute on-tumor pUH on Day 5 after tumor implantation and were then fed with CQ (50 mg/kg daily) thereafter. Prolonged suppression of tumor growth was attained with PLD + pUH + CQ treatment, whereas in PLD + pUH group tumors quickly recurred after an initial inhibition. Treatment with CQ monotherapy had no benefit compared to the control group. Immunohistochemical staining and Western blotting showed that autophagy of cancer cells was blocked for the mice receiving CQ. It indicates that PLD + pUH + CQ is a promising strategy to treat cancer for a long-term inhibition.
Url:
DOI: 10.1038/s41598-019-47345-8
PubMed: 31462676
PubMed Central: 6713759
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<front><div type="abstract" xml:lang="en"><p id="Par1">Autophagy is found to serve as a surviving mechanism for cancer cells. Inhibiting autophagy has been considered as an adjuvant anti-cancer strategy. In this study, we investigated the anti-tumor effect of combining pulsed-wave ultrasound hyperthermia (pUH) enhanced PEGylated liposomal doxorubicin (PLD) delivery with an autophagy inhibitor chloroquine (CQ). BALB/c mice bearing subcutaneous 4T1 tumor received intravenous injection of PLD (10 mg/kg) plus 15-minute on-tumor pUH on Day 5 after tumor implantation and were then fed with CQ (50 mg/kg daily) thereafter. Prolonged suppression of tumor growth was attained with PLD + pUH + CQ treatment, whereas in PLD + pUH group tumors quickly recurred after an initial inhibition. Treatment with CQ monotherapy had no benefit compared to the control group. Immunohistochemical staining and Western blotting showed that autophagy of cancer cells was blocked for the mice receiving CQ. It indicates that PLD + pUH + CQ is a promising strategy to treat cancer for a long-term inhibition.</p>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amaravadi, R" uniqKey="Amaravadi R">R Amaravadi</name>
</author>
<author><name sortKey="Kimmelman, Ac" uniqKey="Kimmelman A">AC Kimmelman</name>
</author>
<author><name sortKey="White, E" uniqKey="White E">E White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, Jm" uniqKey="Levy J">JM Levy</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, Jm" uniqKey="Levy J">JM Levy</name>
</author>
<author><name sortKey="Towers, Cg" uniqKey="Towers C">CG Towers</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, A" uniqKey="Gupta A">A Gupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balic, A" uniqKey="Balic A">A Balic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maes, H" uniqKey="Maes H">H Maes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Geser, A" uniqKey="Geser A">A Geser</name>
</author>
<author><name sortKey="Brubaker, G" uniqKey="Brubaker G">G Brubaker</name>
</author>
<author><name sortKey="Draper, Cc" uniqKey="Draper C">CC Draper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hahn, Gm" uniqKey="Hahn G">GM Hahn</name>
</author>
<author><name sortKey="Braun, J" uniqKey="Braun J">J Braun</name>
</author>
<author><name sortKey="Har Kedar, I" uniqKey="Har Kedar I">I Har-Kedar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thanou, M" uniqKey="Thanou M">M Thanou</name>
</author>
<author><name sortKey="Gedroyc, W" uniqKey="Gedroyc W">W Gedroyc</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lizzi, Fl" uniqKey="Lizzi F">FL Lizzi</name>
</author>
<author><name sortKey="Ostromogilsky, M" uniqKey="Ostromogilsky M">M Ostromogilsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Sk" uniqKey="Wu S">SK Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Sk" uniqKey="Wu S">SK Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsang, Yw" uniqKey="Tsang Y">YW Tsang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirsch, Ha" uniqKey="Hirsch H">HA Hirsch</name>
</author>
<author><name sortKey="Iliopoulos, D" uniqKey="Iliopoulos D">D Iliopoulos</name>
</author>
<author><name sortKey="Tsichlis, Pn" uniqKey="Tsichlis P">PN Tsichlis</name>
</author>
<author><name sortKey="Struhl, K" uniqKey="Struhl K">K Struhl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirsch, Ha" uniqKey="Hirsch H">HA Hirsch</name>
</author>
<author><name sortKey="Iliopoulos, D" uniqKey="Iliopoulos D">D Iliopoulos</name>
</author>
<author><name sortKey="Struhl, K" uniqKey="Struhl K">K Struhl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="King, Ma" uniqKey="King M">MA King</name>
</author>
<author><name sortKey="Ganley, Ig" uniqKey="Ganley I">IG Ganley</name>
</author>
<author><name sortKey="Flemington, V" uniqKey="Flemington V">V Flemington</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choi, Ds" uniqKey="Choi D">DS Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, Mf" uniqKey="Wei M">MF Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Sw" uniqKey="Lee S">SW Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maycotte, P" uniqKey="Maycotte P">P Maycotte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elliott, Ia" uniqKey="Elliott I">IA Elliott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schaaf, Mb" uniqKey="Schaaf M">MB Schaaf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, W" uniqKey="Yang W">W Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ba, Mc" uniqKey="Ba M">MC Ba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartlett, Jj" uniqKey="Bartlett J">JJ Bartlett</name>
</author>
<author><name sortKey="Trivedi, Pc" uniqKey="Trivedi P">PC Trivedi</name>
</author>
<author><name sortKey="Pulinilkunnil, T" uniqKey="Pulinilkunnil T">T Pulinilkunnil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koleini, N" uniqKey="Koleini N">N Koleini</name>
</author>
<author><name sortKey="Kardami, E" uniqKey="Kardami E">E Kardami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pelt, J" uniqKey="Pelt J">J Pelt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, R" uniqKey="Sun R">R Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, M" uniqKey="Shao M">M Shao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wolfram, J" uniqKey="Wolfram J">J Wolfram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lv, T" uniqKey="Lv T">T Lv</name>
</author>
</analytic>
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<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-1296-6334</contrib-id>
<name><surname>Hsu</surname>
<given-names>Yu-Hone</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Chih-Chun</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liang</surname>
<given-names>Po-Chin</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miaw</surname>
<given-names>Shi-Chuen</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Lin</surname>
<given-names>Win-Li</given-names>
</name>
<address><email>winli@ntu.edu.tw</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id>
<institution-id institution-id-type="GRID">grid.19188.39</institution-id>
<institution>Department of Biomedical Engineering,</institution>
<institution>National Taiwan University,</institution>
</institution-wrap>
Taipei, Taiwan</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0572 9992</institution-id>
<institution-id institution-id-type="GRID">grid.415011.0</institution-id>
<institution>Division of Neurosurgery, Department of Surgery,</institution>
<institution>Kaohsiung Veterans General Hospital,</institution>
</institution-wrap>
Kaohsiung, Taiwan</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id>
<institution-id institution-id-type="GRID">grid.19188.39</institution-id>
<institution>Graduate Institute of Immunology, College of Medicine, National Taiwan University,</institution>
</institution-wrap>
Taipei, Taiwan</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0572 7815</institution-id>
<institution-id institution-id-type="GRID">grid.412094.a</institution-id>
<institution>Department of Radiology, Department of Medical Imaging,</institution>
<institution>National Taiwan University Hospital,</institution>
</institution-wrap>
Taipei, Taiwan</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000406229172</institution-id>
<institution-id institution-id-type="GRID">grid.59784.37</institution-id>
<institution>Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes,</institution>
</institution-wrap>
Miaoli, Taiwan</aff>
</contrib-group>
<pub-date pub-type="epub"><day>28</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>28</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>9</volume>
<elocation-id>12448</elocation-id>
<history><date date-type="received"><day>23</day>
<month>4</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>28</day>
<month>6</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Autophagy is found to serve as a surviving mechanism for cancer cells. Inhibiting autophagy has been considered as an adjuvant anti-cancer strategy. In this study, we investigated the anti-tumor effect of combining pulsed-wave ultrasound hyperthermia (pUH) enhanced PEGylated liposomal doxorubicin (PLD) delivery with an autophagy inhibitor chloroquine (CQ). BALB/c mice bearing subcutaneous 4T1 tumor received intravenous injection of PLD (10 mg/kg) plus 15-minute on-tumor pUH on Day 5 after tumor implantation and were then fed with CQ (50 mg/kg daily) thereafter. Prolonged suppression of tumor growth was attained with PLD + pUH + CQ treatment, whereas in PLD + pUH group tumors quickly recurred after an initial inhibition. Treatment with CQ monotherapy had no benefit compared to the control group. Immunohistochemical staining and Western blotting showed that autophagy of cancer cells was blocked for the mice receiving CQ. It indicates that PLD + pUH + CQ is a promising strategy to treat cancer for a long-term inhibition.</p>
</abstract>
<kwd-group kwd-group-type="npg-subject"><title>Subject terms</title>
<kwd>Cancer microenvironment</kwd>
<kwd>Chemotherapy</kwd>
<kwd>Cancer metabolism</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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