TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation
Identifieur interne : 000085 ( Pmc/Curation ); précédent : 000084; suivant : 000086TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation
Auteurs : Suryakant Niture [États-Unis] ; Maxwell A. Gyamfi [États-Unis] ; Minghui Lin [États-Unis, République populaire de Chine] ; Uchechukwu Chimeh [États-Unis] ; Xialan Dong [États-Unis] ; Weifan Zheng [États-Unis] ; John Moore [États-Unis] ; Deepak Kumar [États-Unis]Source :
- Cell Death & Disease [ 2041-4889 ] ; 2020.
Abstract
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define the role of TNFAIP8 in early events associated with development of hepatocellular carcinoma (HCC). Increased TNFAIP8 levels in HCC cells enhanced cell survival by blocking apoptosis, rendering HCC cells more resistant to the anticancer drugs, sorafenib and regorafenib. TNFAIP8 also induced autophagy and steatosis in liver cancer cells. Consistent with these observations, TNFAIP8 blocked AKT/mTOR signaling and showed direct interaction with ATG3-ATG7 proteins. TNFAIP8 also exhibited binding with fatty acids and modulated expression of lipid/fatty-acid metabolizing enzymes. Chronic feeding of mice with alcohol increased hepatic levels of TNFAIP8, autophagy, and steatosis but not in high-fat-fed obese mice. Similarly, higher TNFAIP8 expression was associated with steatotic livers of human patients with a history of alcohol use but not in steatotic patients with no history of alcohol use. Our data indicate a novel role of TNFAIP8 in modulation of drug resistance, autophagy, and hepatic steatosis, all key early events in HCC progression.
Url:
DOI: 10.1038/s41419-020-2369-4
PubMed: 32152268
PubMed Central: 7062894
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000085
Links to Exploration step
PMC:7062894Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation</title>
<author><name sortKey="Niture, Suryakant" sort="Niture, Suryakant" uniqKey="Niture S" first="Suryakant" last="Niture">Suryakant Niture</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gyamfi, Maxwell A" sort="Gyamfi, Maxwell A" uniqKey="Gyamfi M" first="Maxwell A." last="Gyamfi">Maxwell A. Gyamfi</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lin, Minghui" sort="Lin, Minghui" uniqKey="Lin M" first="Minghui" last="Lin">Minghui Lin</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 9803</institution-id>
<institution-id institution-id-type="GRID">grid.412194.b</institution-id>
<institution>Ningxia Medical University, Ningxia Hui Autonomous Region,</institution>
</institution-wrap>
Yinchuan, 750004 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Yinchuan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chimeh, Uchechukwu" sort="Chimeh, Uchechukwu" uniqKey="Chimeh U" first="Uchechukwu" last="Chimeh">Uchechukwu Chimeh</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dong, Xialan" sort="Dong, Xialan" uniqKey="Dong X" first="Xialan" last="Dong">Xialan Dong</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences, Bio-manufacturing Research Institute and Technology Enterprise (BRITE),</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Weifan" sort="Zheng, Weifan" uniqKey="Zheng W" first="Weifan" last="Zheng">Weifan Zheng</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences, Bio-manufacturing Research Institute and Technology Enterprise (BRITE),</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moore, John" sort="Moore, John" uniqKey="Moore J" first="John" last="Moore">John Moore</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kumar, Deepak" sort="Kumar, Deepak" uniqKey="Kumar D" first="Deepak" last="Kumar">Deepak Kumar</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32152268</idno>
<idno type="pmc">7062894</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062894</idno>
<idno type="RBID">PMC:7062894</idno>
<idno type="doi">10.1038/s41419-020-2369-4</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000085</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000085</idno>
<idno type="wicri:Area/Pmc/Curation">000085</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000085</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation</title>
<author><name sortKey="Niture, Suryakant" sort="Niture, Suryakant" uniqKey="Niture S" first="Suryakant" last="Niture">Suryakant Niture</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gyamfi, Maxwell A" sort="Gyamfi, Maxwell A" uniqKey="Gyamfi M" first="Maxwell A." last="Gyamfi">Maxwell A. Gyamfi</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lin, Minghui" sort="Lin, Minghui" uniqKey="Lin M" first="Minghui" last="Lin">Minghui Lin</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 9803</institution-id>
<institution-id institution-id-type="GRID">grid.412194.b</institution-id>
<institution>Ningxia Medical University, Ningxia Hui Autonomous Region,</institution>
</institution-wrap>
Yinchuan, 750004 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Yinchuan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chimeh, Uchechukwu" sort="Chimeh, Uchechukwu" uniqKey="Chimeh U" first="Uchechukwu" last="Chimeh">Uchechukwu Chimeh</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dong, Xialan" sort="Dong, Xialan" uniqKey="Dong X" first="Xialan" last="Dong">Xialan Dong</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences, Bio-manufacturing Research Institute and Technology Enterprise (BRITE),</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Weifan" sort="Zheng, Weifan" uniqKey="Zheng W" first="Weifan" last="Zheng">Weifan Zheng</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences, Bio-manufacturing Research Institute and Technology Enterprise (BRITE),</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moore, John" sort="Moore, John" uniqKey="Moore J" first="John" last="Moore">John Moore</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kumar, Deepak" sort="Kumar, Deepak" uniqKey="Kumar D" first="Deepak" last="Kumar">Deepak Kumar</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Durham</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Death & Disease</title>
<idno type="eISSN">2041-4889</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">Tumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define the role of TNFAIP8 in early events associated with development of hepatocellular carcinoma (HCC). Increased TNFAIP8 levels in HCC cells enhanced cell survival by blocking apoptosis, rendering HCC cells more resistant to the anticancer drugs, sorafenib and regorafenib. TNFAIP8 also induced autophagy and steatosis in liver cancer cells. Consistent with these observations, TNFAIP8 blocked AKT/mTOR signaling and showed direct interaction with ATG3-ATG7 proteins. TNFAIP8 also exhibited binding with fatty acids and modulated expression of lipid/fatty-acid metabolizing enzymes. Chronic feeding of mice with alcohol increased hepatic levels of TNFAIP8, autophagy, and steatosis but not in high-fat-fed obese mice. Similarly, higher TNFAIP8 expression was associated with steatotic livers of human patients with a history of alcohol use but not in steatotic patients with no history of alcohol use. Our data indicate a novel role of TNFAIP8 in modulation of drug resistance, autophagy, and hepatic steatosis, all key early events in HCC progression.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Freundt, Ec" uniqKey="Freundt E">EC Freundt</name>
</author>
<author><name sortKey="Bidere, N" uniqKey="Bidere N">N Bidere</name>
</author>
<author><name sortKey="Lenardo, Mj" uniqKey="Lenardo M">MJ Lenardo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name>
</author>
<author><name sortKey="Whiteside, Tl" uniqKey="Whiteside T">TL Whiteside</name>
</author>
<author><name sortKey="Kasid, U" uniqKey="Kasid U">U Kasid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, H" uniqKey="Sun H">H Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niture, S" uniqKey="Niture S">S Niture</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Day, Tf" uniqKey="Day T">TF Day</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niture, S" uniqKey="Niture S">S Niture</name>
</author>
<author><name sortKey="Moore, J" uniqKey="Moore J">J Moore</name>
</author>
<author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="Xia, B" uniqKey="Xia B">B Xia</name>
</author>
<author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Lou, G" uniqKey="Lou G">G Lou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niture, S" uniqKey="Niture S">S Niture</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, Q" uniqKey="Dong Q">Q Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhi, X" uniqKey="Zhi X">X Zhi</name>
</author>
<author><name sortKey="Zhong, Q" uniqKey="Zhong Q">Q Zhong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chittaranjan, S" uniqKey="Chittaranjan S">S Chittaranjan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Js" uniqKey="Kim J">JS Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ha, Jy" uniqKey="Ha J">JY Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, C" uniqKey="Zhu C">C Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cui, W" uniqKey="Cui W">W Cui</name>
</author>
<author><name sortKey="Chen, Sl" uniqKey="Chen S">SL Chen</name>
</author>
<author><name sortKey="Hu, Kq" uniqKey="Hu K">KQ Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niture, S" uniqKey="Niture S">S Niture</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choi, S" uniqKey="Choi S">S Choi</name>
</author>
<author><name sortKey="Neequaye, P" uniqKey="Neequaye P">P Neequaye</name>
</author>
<author><name sortKey="French, Sw" uniqKey="French S">SW French</name>
</author>
<author><name sortKey="Gonzalez, Fj" uniqKey="Gonzalez F">FJ Gonzalez</name>
</author>
<author><name sortKey="Gyamfi, Ma" uniqKey="Gyamfi M">MA Gyamfi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spruiell, K" uniqKey="Spruiell K">K Spruiell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lowe, Jm" uniqKey="Lowe J">JM Lowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soll, C" uniqKey="Soll C">C Soll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kristensen, Ar" uniqKey="Kristensen A">AR Kristensen</name>
</author>
<author><name sortKey="Gsponer, J" uniqKey="Gsponer J">J Gsponer</name>
</author>
<author><name sortKey="Foster, Lj" uniqKey="Foster L">LJ Foster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frudd, K" uniqKey="Frudd K">K Frudd</name>
</author>
<author><name sortKey="Burgoyne, T" uniqKey="Burgoyne T">T Burgoyne</name>
</author>
<author><name sortKey="Burgoyne, Jr" uniqKey="Burgoyne J">JR Burgoyne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Ss" uniqKey="Wang S">SS Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
<author><name sortKey="Guo, Qs" uniqKey="Guo Q">QS Guo</name>
</author>
<author><name sortKey="Wang, Zw" uniqKey="Wang Z">ZW Wang</name>
</author>
<author><name sortKey="Qian, Hx" uniqKey="Qian H">HX Qian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kawano, Y" uniqKey="Kawano Y">Y Kawano</name>
</author>
<author><name sortKey="Cohen, De" uniqKey="Cohen D">DE Cohen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, R" uniqKey="Singh R">R Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friedman, Sl" uniqKey="Friedman S">SL Friedman</name>
</author>
<author><name sortKey="Neuschwander Tetri, Ba" uniqKey="Neuschwander Tetri B">BA Neuschwander-Tetri</name>
</author>
<author><name sortKey="Rinella, M" uniqKey="Rinella M">M Rinella</name>
</author>
<author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marrero, Ja" uniqKey="Marrero J">JA Marrero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name>
</author>
<author><name sortKey="Yoon, Sk" uniqKey="Yoon S">SK Yoon</name>
</author>
<author><name sortKey="Lencioni, R" uniqKey="Lencioni R">R Lencioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reeves, Hl" uniqKey="Reeves H">HL Reeves</name>
</author>
<author><name sortKey="Zaki, My" uniqKey="Zaki M">MY Zaki</name>
</author>
<author><name sortKey="Day, Cp" uniqKey="Day C">CP Day</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rinella, Me" uniqKey="Rinella M">ME Rinella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y Xing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Tb" uniqKey="Liu T">TB Liu</name>
</author>
<author><name sortKey="Xia, Br" uniqKey="Xia B">BR Xia</name>
</author>
<author><name sortKey="Lu, Yh" uniqKey="Lu Y">YH Lu</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Lou, G" uniqKey="Lou G">G Lou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name>
</author>
<author><name sortKey="Pietrocola, F" uniqKey="Pietrocola F">F Pietrocola</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, Jy" uniqKey="Guo J">JY Guo</name>
</author>
<author><name sortKey="Xia, B" uniqKey="Xia B">B Xia</name>
</author>
<author><name sortKey="White, E" uniqKey="White E">E White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gump, Jm" uniqKey="Gump J">JM Gump</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sui, X" uniqKey="Sui X">X Sui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christian, P" uniqKey="Christian P">P Christian</name>
</author>
<author><name sortKey="Sacco, J" uniqKey="Sacco J">J Sacco</name>
</author>
<author><name sortKey="Adeli, K" uniqKey="Adeli K">K Adeli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamada, E" uniqKey="Yamada E">E Yamada</name>
</author>
<author><name sortKey="Singh, R" uniqKey="Singh R">R Singh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burgoyne, Jr" uniqKey="Burgoyne J">JR Burgoyne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaiser, Se" uniqKey="Kaiser S">SE Kaiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niso Santano, M" uniqKey="Niso Santano M">M Niso-Santano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Codogno, P" uniqKey="Codogno P">P Codogno</name>
</author>
<author><name sortKey="Mehrpour, M" uniqKey="Mehrpour M">M Mehrpour</name>
</author>
<author><name sortKey="Proikas Cezanne, T" uniqKey="Proikas Cezanne T">T Proikas-Cezanne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Wx" uniqKey="Ding W">WX Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, H" uniqKey="Dong H">H Dong</name>
</author>
<author><name sortKey="Czaja, Mj" uniqKey="Czaja M">MJ Czaja</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toshikuni, N" uniqKey="Toshikuni N">N Toshikuni</name>
</author>
<author><name sortKey="Tsutsumi, M" uniqKey="Tsutsumi M">M Tsutsumi</name>
</author>
<author><name sortKey="Arisawa, T" uniqKey="Arisawa T">T Arisawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahli, A" uniqKey="Mahli A">A Mahli</name>
</author>
<author><name sortKey="Hellerbrand, C" uniqKey="Hellerbrand C">C Hellerbrand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boyle, M" uniqKey="Boyle M">M Boyle</name>
</author>
<author><name sortKey="Masson, S" uniqKey="Masson S">S Masson</name>
</author>
<author><name sortKey="Anstee, Qm" uniqKey="Anstee Q">QM Anstee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao, X" uniqKey="Chao X">X Chao</name>
</author>
<author><name sortKey="Ding, Wx" uniqKey="Ding W">WX Ding</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Death Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell Death Dis</journal-id>
<journal-title-group><journal-title>Cell Death & Disease</journal-title>
</journal-title-group>
<issn pub-type="epub">2041-4889</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32152268</article-id>
<article-id pub-id-type="pmc">7062894</article-id>
<article-id pub-id-type="publisher-id">2369</article-id>
<article-id pub-id-type="doi">10.1038/s41419-020-2369-4</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Niture</surname>
<given-names>Suryakant</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gyamfi</surname>
<given-names>Maxwell A.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lin</surname>
<given-names>Minghui</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chimeh</surname>
<given-names>Uchechukwu</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dong</surname>
<given-names>Xialan</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Weifan</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moore</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0418-5116</contrib-id>
<name><surname>Kumar</surname>
<given-names>Deepak</given-names>
</name>
<address><email>dkumar@nccu.edu</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Julius L. Chambers Biomedical Biotechnology Research Institute,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 9803</institution-id>
<institution-id institution-id-type="GRID">grid.412194.b</institution-id>
<institution>Ningxia Medical University, Ningxia Hui Autonomous Region,</institution>
</institution-wrap>
Yinchuan, 750004 China</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences, Bio-manufacturing Research Institute and Technology Enterprise (BRITE),</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000000122955703</institution-id>
<institution-id institution-id-type="GRID">grid.261038.e</institution-id>
<institution>Department of Pharmaceutical Sciences,</institution>
<institution>North Carolina Central University Durham,</institution>
</institution-wrap>
Durham, NC 27707 USA</aff>
</contrib-group>
<pub-date pub-type="epub"><day>9</day>
<month>3</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>9</day>
<month>3</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><month>3</month>
<year>2020</year>
</pub-date>
<volume>11</volume>
<issue>3</issue>
<elocation-id>178</elocation-id>
<history><date date-type="received"><day>23</day>
<month>10</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>8</day>
<month>1</month>
<year>2020</year>
</date>
<date date-type="accepted"><day>9</day>
<month>1</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2020</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Tumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define the role of TNFAIP8 in early events associated with development of hepatocellular carcinoma (HCC). Increased TNFAIP8 levels in HCC cells enhanced cell survival by blocking apoptosis, rendering HCC cells more resistant to the anticancer drugs, sorafenib and regorafenib. TNFAIP8 also induced autophagy and steatosis in liver cancer cells. Consistent with these observations, TNFAIP8 blocked AKT/mTOR signaling and showed direct interaction with ATG3-ATG7 proteins. TNFAIP8 also exhibited binding with fatty acids and modulated expression of lipid/fatty-acid metabolizing enzymes. Chronic feeding of mice with alcohol increased hepatic levels of TNFAIP8, autophagy, and steatosis but not in high-fat-fed obese mice. Similarly, higher TNFAIP8 expression was associated with steatotic livers of human patients with a history of alcohol use but not in steatotic patients with no history of alcohol use. Our data indicate a novel role of TNFAIP8 in modulation of drug resistance, autophagy, and hepatic steatosis, all key early events in HCC progression.</p>
</abstract>
<kwd-group kwd-group-type="npg-subject"><title>Subject terms</title>
<kwd>Oncogenes</kwd>
<kwd>Macroautophagy</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">https://doi.org/10.13039/100006545</institution-id>
<institution>U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD)</institution>
</institution-wrap>
</funding-source>
<award-id>U54MD012392, R01MD012767</award-id>
<award-id>U54AA019765</award-id>
<principal-award-recipient><name><surname>Gyamfi</surname>
<given-names>Maxwell A.</given-names>
</name>
<name><surname>Kumar</surname>
<given-names>Deepak</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution>Deepak Kumar</institution>
</funding-source>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution>U.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health Disparities (NIMHD)</institution>
</funding-source>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution>Maxwell Gymfi</institution>
</funding-source>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2020</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000085 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000085 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:7062894 |texte= TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:32152268" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |