Endoplasmic Reticulum-Associated Degradation-Dependent Processing in Cross-Presentation and Its Potential for Dendritic Cell Vaccinations: A Review
Identifieur interne : 000B00 ( Pmc/Corpus ); précédent : 000A99; suivant : 000B01Endoplasmic Reticulum-Associated Degradation-Dependent Processing in Cross-Presentation and Its Potential for Dendritic Cell Vaccinations: A Review
Auteurs : Jun Imai ; Sayaka Ohashi ; Takahiro SakaiSource :
- Pharmaceutics [ 1999-4923 ] ; 2020.
Abstract
While the success of dendritic cell (DC) vaccination largely depends on cross-presentation (CP) efficiency, the precise molecular mechanism of CP is not yet characterized. Recent research revealed that endoplasmic reticulum (ER)-associated degradation (ERAD), which was first identified as part of the protein quality control system in the ER, plays a pivotal role in the processing of extracellular proteins in CP. The discovery of ERAD-dependent processing strongly suggests that the properties of extracellular antigens are one of the keys to effective DC vaccination, in addition to DC subsets and the maturation of these cells. In this review, we address recent advances in CP, focusing on the molecular mechanisms of the ERAD-dependent processing of extracellular proteins. As ERAD itself and the ERAD-dependent processing in CP share cellular machinery, enhancing the recognition of extracellular proteins, such as the ERAD substrate, by ex vivo methods may serve to improve the efficacy of DC vaccination.
Url:
DOI: 10.3390/pharmaceutics12020153
PubMed: 32070016
PubMed Central: 7076524
Links to Exploration step
PMC:7076524Le document en format XML
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<author><name sortKey="Ohashi, Sayaka" sort="Ohashi, Sayaka" uniqKey="Ohashi S" first="Sayaka" last="Ohashi">Sayaka Ohashi</name>
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<author><name sortKey="Sakai, Takahiro" sort="Sakai, Takahiro" uniqKey="Sakai T" first="Takahiro" last="Sakai">Takahiro Sakai</name>
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<author><name sortKey="Ohashi, Sayaka" sort="Ohashi, Sayaka" uniqKey="Ohashi S" first="Sayaka" last="Ohashi">Sayaka Ohashi</name>
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<front><div type="abstract" xml:lang="en"><p>While the success of dendritic cell (DC) vaccination largely depends on cross-presentation (CP) efficiency, the precise molecular mechanism of CP is not yet characterized. Recent research revealed that endoplasmic reticulum (ER)-associated degradation (ERAD), which was first identified as part of the protein quality control system in the ER, plays a pivotal role in the processing of extracellular proteins in CP. The discovery of ERAD-dependent processing strongly suggests that the properties of extracellular antigens are one of the keys to effective DC vaccination, in addition to DC subsets and the maturation of these cells. In this review, we address recent advances in CP, focusing on the molecular mechanisms of the ERAD-dependent processing of extracellular proteins. As ERAD itself and the ERAD-dependent processing in CP share cellular machinery, enhancing the recognition of extracellular proteins, such as the ERAD substrate, by ex vivo methods may serve to improve the efficacy of DC vaccination.</p>
</div>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Finn, O J" uniqKey="Finn O">O.J. Finn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stanley, M" uniqKey="Stanley M">M. Stanley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, D S" uniqKey="Chen D">D.S. Chen</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I. Mellman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sigal, L J" uniqKey="Sigal L">L.J. Sigal</name>
</author>
<author><name sortKey="Crotty, S" uniqKey="Crotty S">S. Crotty</name>
</author>
<author><name sortKey="Andino, R" uniqKey="Andino R">R. Andino</name>
</author>
<author><name sortKey="Rock, K L" uniqKey="Rock K">K.L. Rock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonifaz, L" uniqKey="Bonifaz L">L. Bonifaz</name>
</author>
<author><name sortKey="Bonnyay, D" uniqKey="Bonnyay D">D. Bonnyay</name>
</author>
<author><name sortKey="Mahnke, K" uniqKey="Mahnke K">K. Mahnke</name>
</author>
<author><name sortKey="Rivera, M" uniqKey="Rivera M">M. Rivera</name>
</author>
<author><name sortKey="Nussenzweig, M C" uniqKey="Nussenzweig M">M.C. Nussenzweig</name>
</author>
<author><name sortKey="Steinman, R M" uniqKey="Steinman R">R.M. Steinman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Den Haan, J M" uniqKey="Den Haan J">J.M. Den Haan</name>
</author>
<author><name sortKey="Bevan, M J" uniqKey="Bevan M">M.J. Bevan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heath, W R" uniqKey="Heath W">W.R. Heath</name>
</author>
<author><name sortKey="Carbone, F R" uniqKey="Carbone F">F.R. Carbone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mittal, D" uniqKey="Mittal D">D. Mittal</name>
</author>
<author><name sortKey="Gubin, M M" uniqKey="Gubin M">M.M. Gubin</name>
</author>
<author><name sortKey="Schreiber, R D" uniqKey="Schreiber R">R.D. Schreiber</name>
</author>
<author><name sortKey="Smyth, M J" uniqKey="Smyth M">M.J. Smyth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lennerz, V" uniqKey="Lennerz V">V. Lennerz</name>
</author>
<author><name sortKey="Fatho, M" uniqKey="Fatho M">M. Fatho</name>
</author>
<author><name sortKey="Gentilini, C" uniqKey="Gentilini C">C. Gentilini</name>
</author>
<author><name sortKey="Frye, R A" uniqKey="Frye R">R.A. Frye</name>
</author>
<author><name sortKey="Lifke, A" uniqKey="Lifke A">A. Lifke</name>
</author>
<author><name sortKey="Ferel, D" uniqKey="Ferel D">D. Ferel</name>
</author>
<author><name sortKey="Wolfel, C" uniqKey="Wolfel C">C. Wölfel</name>
</author>
<author><name sortKey="Huber, C" uniqKey="Huber C">C. Huber</name>
</author>
<author><name sortKey="Wolfel, T" uniqKey="Wolfel T">T. Wölfel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baurain, J F" uniqKey="Baurain J">J.F. Baurain</name>
</author>
<author><name sortKey="Colau, D" uniqKey="Colau D">D. Colau</name>
</author>
<author><name sortKey="Van Baren, N" uniqKey="Van Baren N">N. van Baren</name>
</author>
<author><name sortKey="Landry, C" uniqKey="Landry C">C. Landry</name>
</author>
<author><name sortKey="Martelange, V" uniqKey="Martelange V">V. Martelange</name>
</author>
<author><name sortKey="Vikkula, M" uniqKey="Vikkula M">M. Vikkula</name>
</author>
<author><name sortKey="Boon, T" uniqKey="Boon T">T. Boon</name>
</author>
<author><name sortKey="Coulie, P G" uniqKey="Coulie P">P.G. Coulie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salmon, H" uniqKey="Salmon H">H. Salmon</name>
</author>
<author><name sortKey="Idoyaga, J" uniqKey="Idoyaga J">J. Idoyaga</name>
</author>
<author><name sortKey="Rahman, A" uniqKey="Rahman A">A. Rahman</name>
</author>
<author><name sortKey="Leboeuf, M" uniqKey="Leboeuf M">M. Leboeuf</name>
</author>
<author><name sortKey="Remark, R" uniqKey="Remark R">R. Remark</name>
</author>
<author><name sortKey="Jordan, S" uniqKey="Jordan S">S. Jordan</name>
</author>
<author><name sortKey="Casanova Acebes, M" uniqKey="Casanova Acebes M">M. Casanova-Acebes</name>
</author>
<author><name sortKey="Khudoynazarova, M" uniqKey="Khudoynazarova M">M. Khudoynazarova</name>
</author>
<author><name sortKey="Agudo, J" uniqKey="Agudo J">J. Agudo</name>
</author>
<author><name sortKey="Tung, N" uniqKey="Tung N">N. Tung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spranger, S" uniqKey="Spranger S">S. Spranger</name>
</author>
<author><name sortKey="Dai, D" uniqKey="Dai D">D. Dai</name>
</author>
<author><name sortKey="Horton, B" uniqKey="Horton B">B. Horton</name>
</author>
<author><name sortKey="Gajewski, T F" uniqKey="Gajewski T">T.F. Gajewski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Broz, M L" uniqKey="Broz M">M.L. Broz</name>
</author>
<author><name sortKey="Binnewies, M" uniqKey="Binnewies M">M. Binnewies</name>
</author>
<author><name sortKey="Boldajipour, B" uniqKey="Boldajipour B">B. Boldajipour</name>
</author>
<author><name sortKey="Nelson, A E" uniqKey="Nelson A">A.E. Nelson</name>
</author>
<author><name sortKey="Pollack, J L" uniqKey="Pollack J">J.L. Pollack</name>
</author>
<author><name sortKey="Erle, D J" uniqKey="Erle D">D.J. Erle</name>
</author>
<author><name sortKey="Barczak, A" uniqKey="Barczak A">A. Barczak</name>
</author>
<author><name sortKey="Rosenblum, M D" uniqKey="Rosenblum M">M.D. Rosenblum</name>
</author>
<author><name sortKey="Daud, A" uniqKey="Daud A">A. Daud</name>
</author>
<author><name sortKey="Barber, D L" uniqKey="Barber D">D.L. Barber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hampton, R Y" uniqKey="Hampton R">R.Y. Hampton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsai, B" uniqKey="Tsai B">B. Tsai</name>
</author>
<author><name sortKey="Ye, Y" uniqKey="Ye Y">Y. Ye</name>
</author>
<author><name sortKey="Rapoport, T A" uniqKey="Rapoport T">T.A. Rapoport</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Preston, G M" uniqKey="Preston G">G.M. Preston</name>
</author>
<author><name sortKey="Brodsky, J L" uniqKey="Brodsky J">J.L. Brodsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, Y" uniqKey="Tamura Y">Y. Tamura</name>
</author>
<author><name sortKey="Hirohashi, Y" uniqKey="Hirohashi Y">Y. Hirohashi</name>
</author>
<author><name sortKey="Kutomi, G" uniqKey="Kutomi G">G. Kutomi</name>
</author>
<author><name sortKey="Nakanishi, K" uniqKey="Nakanishi K">K. Nakanishi</name>
</author>
<author><name sortKey="Kamiguchi, K" uniqKey="Kamiguchi K">K. Kamiguchi</name>
</author>
<author><name sortKey="Torigoe, T" uniqKey="Torigoe T">T. Torigoe</name>
</author>
<author><name sortKey="Sato, N" uniqKey="Sato N">N. Sato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Basu, S" uniqKey="Basu S">S. Basu</name>
</author>
<author><name sortKey="Srivastava, P K" uniqKey="Srivastava P">P.K. Srivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Srivastava, P" uniqKey="Srivastava P">P. Srivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Constantino, J" uniqKey="Constantino J">J. Constantino</name>
</author>
<author><name sortKey="Gomes, C" uniqKey="Gomes C">C. Gomes</name>
</author>
<author><name sortKey="Falcao, A" uniqKey="Falcao A">A. Falcão</name>
</author>
<author><name sortKey="Cruz, M T" uniqKey="Cruz M">M.T. Cruz</name>
</author>
<author><name sortKey="Neves, B M" uniqKey="Neves B">B.M. Neves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hodi, F S" uniqKey="Hodi F">F.S. Hodi</name>
</author>
<author><name sortKey="O Ay, S J" uniqKey="O Ay S">S.J. O’Day</name>
</author>
<author><name sortKey="Mcdermott, D F" uniqKey="Mcdermott D">D.F. McDermott</name>
</author>
<author><name sortKey="Weber, R W" uniqKey="Weber R">R.W. Weber</name>
</author>
<author><name sortKey="Sosman, J A" uniqKey="Sosman J">J.A. Sosman</name>
</author>
<author><name sortKey="Haanen, J B" uniqKey="Haanen J">J.B. Haanen</name>
</author>
<author><name sortKey="Gonzalez, R" uniqKey="Gonzalez R">R. Gonzalez</name>
</author>
<author><name sortKey="Robert, C" uniqKey="Robert C">C. Robert</name>
</author>
<author><name sortKey="Schadendorf, D" uniqKey="Schadendorf D">D. Schadendorf</name>
</author>
<author><name sortKey="Hassel, J C" uniqKey="Hassel J">J.C. Hassel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heery, C R" uniqKey="Heery C">C.R. Heery</name>
</author>
<author><name sortKey="O Ullivan Coyne, G" uniqKey="O Ullivan Coyne G">G. O’Sullivan-Coyne</name>
</author>
<author><name sortKey="Madan, R A" uniqKey="Madan R">R.A. Madan</name>
</author>
<author><name sortKey="Cordes, L" uniqKey="Cordes L">L. Cordes</name>
</author>
<author><name sortKey="Rajan, A" uniqKey="Rajan A">A. Rajan</name>
</author>
<author><name sortKey="Rauckhorst, M" uniqKey="Rauckhorst M">M. Rauckhorst</name>
</author>
<author><name sortKey="Lamping, E" uniqKey="Lamping E">E. Lamping</name>
</author>
<author><name sortKey="Oyelakin, I" uniqKey="Oyelakin I">I. Oyelakin</name>
</author>
<author><name sortKey="Marte, J L" uniqKey="Marte J">J.L. Marté</name>
</author>
<author><name sortKey="Lepone, L M" uniqKey="Lepone L">L.M. Lepone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Syn, N L" uniqKey="Syn N">N.L. Syn</name>
</author>
<author><name sortKey="Teng, M W L" uniqKey="Teng M">M.W.L. Teng</name>
</author>
<author><name sortKey="Mok, T S K" uniqKey="Mok T">T.S.K. Mok</name>
</author>
<author><name sortKey="Soo, R A" uniqKey="Soo R">R.A. Soo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Topalian, S L" uniqKey="Topalian S">S.L. Topalian</name>
</author>
<author><name sortKey="Hodi, F S" uniqKey="Hodi F">F.S. Hodi</name>
</author>
<author><name sortKey="Brahmer, J R" uniqKey="Brahmer J">J.R. Brahmer</name>
</author>
<author><name sortKey="Gettinger, S N" uniqKey="Gettinger S">S.N. Gettinger</name>
</author>
<author><name sortKey="Smith, D C" uniqKey="Smith D">D.C. Smith</name>
</author>
<author><name sortKey="Mcdermott, D F" uniqKey="Mcdermott D">D.F. McDermott</name>
</author>
<author><name sortKey="Powderly, J D" uniqKey="Powderly J">J.D. Powderly</name>
</author>
<author><name sortKey="Carvajal, R D" uniqKey="Carvajal R">R.D. Carvajal</name>
</author>
<author><name sortKey="Sosman, J A" uniqKey="Sosman J">J.A. Sosman</name>
</author>
<author><name sortKey="Atkins, M B" uniqKey="Atkins M">M.B. Atkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garris, C S" uniqKey="Garris C">C.S. Garris</name>
</author>
<author><name sortKey="Arlauckas, S P" uniqKey="Arlauckas S">S.P. Arlauckas</name>
</author>
<author><name sortKey="Kohler, R H" uniqKey="Kohler R">R.H. Kohler</name>
</author>
<author><name sortKey="Trefny, M P" uniqKey="Trefny M">M.P. Trefny</name>
</author>
<author><name sortKey="Garren, S" uniqKey="Garren S">S. Garren</name>
</author>
<author><name sortKey="Piot, C" uniqKey="Piot C">C. Piot</name>
</author>
<author><name sortKey="Engblom, C" uniqKey="Engblom C">C. Engblom</name>
</author>
<author><name sortKey="Pfirschke, C" uniqKey="Pfirschke C">C. Pfirschke</name>
</author>
<author><name sortKey="Siwicki, M" uniqKey="Siwicki M">M. Siwicki</name>
</author>
<author><name sortKey="Gungabeesoon, J" uniqKey="Gungabeesoon J">J. Gungabeesoon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreutz, M" uniqKey="Kreutz M">M. Kreutz</name>
</author>
<author><name sortKey="Tacken, P J" uniqKey="Tacken P">P.J. Tacken</name>
</author>
<author><name sortKey="Figdor, C G" uniqKey="Figdor C">C.G. Figdor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ofuji, K" uniqKey="Ofuji K">K. Ofuji</name>
</author>
<author><name sortKey="Tada, Y" uniqKey="Tada Y">Y. Tada</name>
</author>
<author><name sortKey="Yoshikawa, T" uniqKey="Yoshikawa T">T. Yoshikawa</name>
</author>
<author><name sortKey="Shimomura, M" uniqKey="Shimomura M">M. Shimomura</name>
</author>
<author><name sortKey="Yoshimura, M" uniqKey="Yoshimura M">M. Yoshimura</name>
</author>
<author><name sortKey="Saito, K" uniqKey="Saito K">K. Saito</name>
</author>
<author><name sortKey="Nakamoto, Y" uniqKey="Nakamoto Y">Y. Nakamoto</name>
</author>
<author><name sortKey="Nakatsura, T" uniqKey="Nakatsura T">T. Nakatsura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teitz Tennenbaum, S" uniqKey="Teitz Tennenbaum S">S. Teitz-Tennenbaum</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name>
</author>
<author><name sortKey="Rynkiewicz, S" uniqKey="Rynkiewicz S">S. Rynkiewicz</name>
</author>
<author><name sortKey="Ito, F" uniqKey="Ito F">F. Ito</name>
</author>
<author><name sortKey="Davis, M A" uniqKey="Davis M">M.A. Davis</name>
</author>
<author><name sortKey="Mcginn, C J" uniqKey="Mcginn C">C.J. Mcginn</name>
</author>
<author><name sortKey="Chang, A E" uniqKey="Chang A">A.E. Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steinman, R M" uniqKey="Steinman R">R.M. Steinman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schlitzer, A" uniqKey="Schlitzer A">A. Schlitzer</name>
</author>
<author><name sortKey="Mcgovern, N" uniqKey="Mcgovern N">N. McGovern</name>
</author>
<author><name sortKey="Ginhoux, F" uniqKey="Ginhoux F">F. Ginhoux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collin, M" uniqKey="Collin M">M. Collin</name>
</author>
<author><name sortKey="Bigley, V" uniqKey="Bigley V">V. Bigley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merad, M" uniqKey="Merad M">M. Merad</name>
</author>
<author><name sortKey="Sathe, P" uniqKey="Sathe P">P. Sathe</name>
</author>
<author><name sortKey="Helft, J" uniqKey="Helft J">J. Helft</name>
</author>
<author><name sortKey="Miller, J" uniqKey="Miller J">J. Miller</name>
</author>
<author><name sortKey="Mortha, A" uniqKey="Mortha A">A. Mortha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bottcher, J P" uniqKey="Bottcher J">J.P. Böttcher</name>
</author>
<author><name sortKey="Reis Sousa, C" uniqKey="Reis Sousa C">C. Reis Sousa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Demoulin, S" uniqKey="Demoulin S">S. Demoulin</name>
</author>
<author><name sortKey="Herfs, M" uniqKey="Herfs M">M. Herfs</name>
</author>
<author><name sortKey="Delvenne, P" uniqKey="Delvenne P">P. Delvenne</name>
</author>
<author><name sortKey="Hubert, P" uniqKey="Hubert P">P. Hubert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guilliams, M" uniqKey="Guilliams M">M. Guilliams</name>
</author>
<author><name sortKey="Ginhoux, F" uniqKey="Ginhoux F">F. Ginhoux</name>
</author>
<author><name sortKey="Jakubzick, C" uniqKey="Jakubzick C">C. Jakubzick</name>
</author>
<author><name sortKey="Naik, S H" uniqKey="Naik S">S.H. Naik</name>
</author>
<author><name sortKey="Onai, N" uniqKey="Onai N">N. Onai</name>
</author>
<author><name sortKey="Schraml, B U" uniqKey="Schraml B">B.U. Schraml</name>
</author>
<author><name sortKey="Segura, E" uniqKey="Segura E">E. Segura</name>
</author>
<author><name sortKey="Tussiwand, R" uniqKey="Tussiwand R">R. Tussiwand</name>
</author>
<author><name sortKey="Yona, S" uniqKey="Yona S">S. Yona</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Segura, E" uniqKey="Segura E">E. Segura</name>
</author>
<author><name sortKey="Albiston, A L" uniqKey="Albiston A">A.L. Albiston</name>
</author>
<author><name sortKey="Wicks, I P" uniqKey="Wicks I">I.P. Wicks</name>
</author>
<author><name sortKey="Chai, S Y" uniqKey="Chai S">S.Y. Chai</name>
</author>
<author><name sortKey="Villadangos, J A" uniqKey="Villadangos J">J.A. Villadangos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Villani, A C" uniqKey="Villani A">A.C. Villani</name>
</author>
<author><name sortKey="Satija, R" uniqKey="Satija R">R. Satija</name>
</author>
<author><name sortKey="Reynolds, G" uniqKey="Reynolds G">G. Reynolds</name>
</author>
<author><name sortKey="Sarkizova, S" uniqKey="Sarkizova S">S. Sarkizova</name>
</author>
<author><name sortKey="Shekhar, K" uniqKey="Shekhar K">K. Shekhar</name>
</author>
<author><name sortKey="Fletcher, J" uniqKey="Fletcher J">J. Fletcher</name>
</author>
<author><name sortKey="Griesbeck, M" uniqKey="Griesbeck M">M. Griesbeck</name>
</author>
<author><name sortKey="Butler, A" uniqKey="Butler A">A. Butler</name>
</author>
<author><name sortKey="Zheng, S" uniqKey="Zheng S">S. Zheng</name>
</author>
<author><name sortKey="Lazo, S" uniqKey="Lazo S">S. Lazo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamphorst, A O" uniqKey="Kamphorst A">A.O. Kamphorst</name>
</author>
<author><name sortKey="Guermonprez, P" uniqKey="Guermonprez P">P. Guermonprez</name>
</author>
<author><name sortKey="Dudziak, D" uniqKey="Dudziak D">D. Dudziak</name>
</author>
<author><name sortKey="Nussenzweig, M C" uniqKey="Nussenzweig M">M.C. Nussenzweig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eickhoff, S" uniqKey="Eickhoff S">S. Eickhoff</name>
</author>
<author><name sortKey="Brewitz, A" uniqKey="Brewitz A">A. Brewitz</name>
</author>
<author><name sortKey="Gerner, M Y" uniqKey="Gerner M">M.Y. Gerner</name>
</author>
<author><name sortKey="Klauschen, F" uniqKey="Klauschen F">F. Klauschen</name>
</author>
<author><name sortKey="Komander, K" uniqKey="Komander K">K. Komander</name>
</author>
<author><name sortKey="Hemmi, H" uniqKey="Hemmi H">H. Hemmi</name>
</author>
<author><name sortKey="Garbi, N" uniqKey="Garbi N">N. Garbi</name>
</author>
<author><name sortKey="Kaisho, T" uniqKey="Kaisho T">T. Kaisho</name>
</author>
<author><name sortKey="Germain, R N" uniqKey="Germain R">R.N. Germain</name>
</author>
<author><name sortKey="Kastenmuller, W" uniqKey="Kastenmuller W">W. Kastenmüller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hor, J L" uniqKey="Hor J">J.L. Hor</name>
</author>
<author><name sortKey="Whitney, P G" uniqKey="Whitney P">P.G. Whitney</name>
</author>
<author><name sortKey="Zaid, A" uniqKey="Zaid A">A. Zaid</name>
</author>
<author><name sortKey="Brooks, A G" uniqKey="Brooks A">A.G. Brooks</name>
</author>
<author><name sortKey="Heath, W R" uniqKey="Heath W">W.R. Heath</name>
</author>
<author><name sortKey="Mueller, S N" uniqKey="Mueller S">S.N. Mueller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, J C" uniqKey="Sun J">J.C. Sun</name>
</author>
<author><name sortKey="Williams, M A" uniqKey="Williams M">M.A. Williams</name>
</author>
<author><name sortKey="Bevan, M J" uniqKey="Bevan M">M.J. Bevan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hochrein, H" uniqKey="Hochrein H">H. Hochrein</name>
</author>
<author><name sortKey="Shortman, K" uniqKey="Shortman K">K. Shortman</name>
</author>
<author><name sortKey="Vremec, D" uniqKey="Vremec D">D. Vremec</name>
</author>
<author><name sortKey="Scott, B" uniqKey="Scott B">B. Scott</name>
</author>
<author><name sortKey="Hertzog, P" uniqKey="Hertzog P">P. Hertzog</name>
</author>
<author><name sortKey="O Eeffe, M" uniqKey="O Eeffe M">M. O’Keeffe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mashayekhi, M" uniqKey="Mashayekhi M">M. Mashayekhi</name>
</author>
<author><name sortKey="Sandau, M M" uniqKey="Sandau M">M.M. Sandau</name>
</author>
<author><name sortKey="Dunay, I R" uniqKey="Dunay I">I.R. Dunay</name>
</author>
<author><name sortKey="Frickel, E M" uniqKey="Frickel E">E.M. Frickel</name>
</author>
<author><name sortKey="Khan, A" uniqKey="Khan A">A. Khan</name>
</author>
<author><name sortKey="Goldszmid, R S" uniqKey="Goldszmid R">R.S. Goldszmid</name>
</author>
<author><name sortKey="Sher, A" uniqKey="Sher A">A. Sher</name>
</author>
<author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name>
</author>
<author><name sortKey="Murphy, T L" uniqKey="Murphy T">T.L. Murphy</name>
</author>
<author><name sortKey="Sibley, L D" uniqKey="Sibley L">L.D. Sibley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dudziak, D" uniqKey="Dudziak D">D. Dudziak</name>
</author>
<author><name sortKey="Kamphorst, A O" uniqKey="Kamphorst A">A.O. Kamphorst</name>
</author>
<author><name sortKey="Heidkamp, G F" uniqKey="Heidkamp G">G.F. Heidkamp</name>
</author>
<author><name sortKey="Buchholz, V R" uniqKey="Buchholz V">V.R. Buchholz</name>
</author>
<author><name sortKey="Trumpfheller, C" uniqKey="Trumpfheller C">C. Trumpfheller</name>
</author>
<author><name sortKey="Yamazaki, S" uniqKey="Yamazaki S">S. Yamazaki</name>
</author>
<author><name sortKey="Cheong, C" uniqKey="Cheong C">C. Cheong</name>
</author>
<author><name sortKey="Liu, K" uniqKey="Liu K">K. Liu</name>
</author>
<author><name sortKey="Lee, H W" uniqKey="Lee H">H.W. Lee</name>
</author>
<author><name sortKey="Park, C G" uniqKey="Park C">C.G. Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanchez Paulete, A R" uniqKey="Sanchez Paulete A">A.R. Sánchez-Paulete</name>
</author>
<author><name sortKey="Cueto, F J" uniqKey="Cueto F">F.J. Cueto</name>
</author>
<author><name sortKey="Martinez L Pez, M" uniqKey="Martinez L Pez M">M. Martínez-López</name>
</author>
<author><name sortKey="Labiano, S" uniqKey="Labiano S">S. Labiano</name>
</author>
<author><name sortKey="Morales Kastresana, A" uniqKey="Morales Kastresana A">A. Morales-Kastresana</name>
</author>
<author><name sortKey="Rodriguez Ruiz, M E" uniqKey="Rodriguez Ruiz M">M.E. Rodríguez-Ruiz</name>
</author>
<author><name sortKey="Jure Kunkel, M" uniqKey="Jure Kunkel M">M. Jure-Kunkel</name>
</author>
<author><name sortKey="Azpilikueta, A" uniqKey="Azpilikueta A">A. Azpilikueta</name>
</author>
<author><name sortKey="Aznar, M A" uniqKey="Aznar M">M.A. Aznar</name>
</author>
<author><name sortKey="Quetglas, J I" uniqKey="Quetglas J">J.I. Quetglas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barry, K C" uniqKey="Barry K">K.C. Barry</name>
</author>
<author><name sortKey="Hsu, J" uniqKey="Hsu J">J. Hsu</name>
</author>
<author><name sortKey="Broz, M L" uniqKey="Broz M">M.L. Broz</name>
</author>
<author><name sortKey="Cueto, F J" uniqKey="Cueto F">F.J. Cueto</name>
</author>
<author><name sortKey="Binnewies, M" uniqKey="Binnewies M">M. Binnewies</name>
</author>
<author><name sortKey="Combes, A J" uniqKey="Combes A">A.J. Combes</name>
</author>
<author><name sortKey="Nelson, A E" uniqKey="Nelson A">A.E. Nelson</name>
</author>
<author><name sortKey="Loo, K" uniqKey="Loo K">K. Loo</name>
</author>
<author><name sortKey="Kumar, R" uniqKey="Kumar R">R. Kumar</name>
</author>
<author><name sortKey="Rosenblum, M D" uniqKey="Rosenblum M">M.D. Rosenblum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chiang, M C" uniqKey="Chiang M">M.C. Chiang</name>
</author>
<author><name sortKey="Chiang, M C" uniqKey="Chiang M">M.C. Chiang</name>
</author>
<author><name sortKey="Tullett, K M" uniqKey="Tullett K">K.M. Tullett</name>
</author>
<author><name sortKey="Lee, Y S" uniqKey="Lee Y">Y.S. Lee</name>
</author>
<author><name sortKey="Idris, A" uniqKey="Idris A">A. Idris</name>
</author>
<author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name>
</author>
<author><name sortKey="Mcdonald, K J" uniqKey="Mcdonald K">K.J. McDonald</name>
</author>
<author><name sortKey="Kassianos, A" uniqKey="Kassianos A">A. Kassianos</name>
</author>
<author><name sortKey="Leal Rojas, I M" uniqKey="Leal Rojas I">I.M. Leal Rojas</name>
</author>
<author><name sortKey="Jeet, V" uniqKey="Jeet V">V. Jeet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sittig, S P" uniqKey="Sittig S">S.P. Sittig</name>
</author>
<author><name sortKey="Bakdash, G" uniqKey="Bakdash G">G. Bakdash</name>
</author>
<author><name sortKey="Weiden, J" uniqKey="Weiden J">J. Weiden</name>
</author>
<author><name sortKey="Skold, A E" uniqKey="Skold A">A.E. Sköld</name>
</author>
<author><name sortKey="Tel, J" uniqKey="Tel J">J. Tel</name>
</author>
<author><name sortKey="Figdor, C G" uniqKey="Figdor C">C.G. Figdor</name>
</author>
<author><name sortKey="De Vries, I J" uniqKey="De Vries I">I.J. de Vries</name>
</author>
<author><name sortKey="Schreibelt, G" uniqKey="Schreibelt G">G. Schreibelt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Segura, E" uniqKey="Segura E">E. Segura</name>
</author>
<author><name sortKey="Durand, M" uniqKey="Durand M">M. Durand</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yin, X" uniqKey="Yin X">X. Yin</name>
</author>
<author><name sortKey="Yu, H" uniqKey="Yu H">H. Yu</name>
</author>
<author><name sortKey="Jin, X" uniqKey="Jin X">X. Jin</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Guo, H" uniqKey="Guo H">H. Guo</name>
</author>
<author><name sortKey="Shi, Q" uniqKey="Shi Q">Q. Shi</name>
</author>
<author><name sortKey="Yin, Z" uniqKey="Yin Z">Z. Yin</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Liu, R" uniqKey="Liu R">R. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitchell, D" uniqKey="Mitchell D">D. Mitchell</name>
</author>
<author><name sortKey="Chintala, S" uniqKey="Chintala S">S. Chintala</name>
</author>
<author><name sortKey="Dey, M" uniqKey="Dey M">M. Dey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Di Pucchio, T" uniqKey="Di Pucchio T">T. Di Pucchio</name>
</author>
<author><name sortKey="Chatterjee, B" uniqKey="Chatterjee B">B. Chatterjee</name>
</author>
<author><name sortKey="Smed Sorensen, A" uniqKey="Smed Sorensen A">A. Smed-Sörensen</name>
</author>
<author><name sortKey="Clayton, S" uniqKey="Clayton S">S. Clayton</name>
</author>
<author><name sortKey="Palazzo, A" uniqKey="Palazzo A">A. Palazzo</name>
</author>
<author><name sortKey="Montes, M" uniqKey="Montes M">M. Montes</name>
</author>
<author><name sortKey="Xue, Y" uniqKey="Xue Y">Y. Xue</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I. Mellman</name>
</author>
<author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J. Banchereau</name>
</author>
<author><name sortKey="Connolly, J E" uniqKey="Connolly J">J.E. Connolly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leon, B" uniqKey="Leon B">B. Leon</name>
</author>
<author><name sortKey="Martinez Del Hoyo, G" uniqKey="Martinez Del Hoyo G">G. Martinez del Hoyo</name>
</author>
<author><name sortKey="Parrillas, V" uniqKey="Parrillas V">V. Parrillas</name>
</author>
<author><name sortKey="Vargas, H H" uniqKey="Vargas H">H.H. Vargas</name>
</author>
<author><name sortKey="Sanchez Mateos, P" uniqKey="Sanchez Mateos P">P. Sanchez-Mateos</name>
</author>
<author><name sortKey="Longo, N" uniqKey="Longo N">N. Longo</name>
</author>
<author><name sortKey="Lopez Bravo, M" uniqKey="Lopez Bravo M">M. Lopez-Bravo</name>
</author>
<author><name sortKey="Ardavin, C" uniqKey="Ardavin C">C. Ardavin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Auffray, C" uniqKey="Auffray C">C. Auffray</name>
</author>
<author><name sortKey="Fogg, D K" uniqKey="Fogg D">D.K. Fogg</name>
</author>
<author><name sortKey="Narni Mancinelli, E" uniqKey="Narni Mancinelli E">E. Narni-Mancinelli</name>
</author>
<author><name sortKey="Senechal, B" uniqKey="Senechal B">B. Senechal</name>
</author>
<author><name sortKey="Trouillet, C" uniqKey="Trouillet C">C. Trouillet</name>
</author>
<author><name sortKey="Saederup, N" uniqKey="Saederup N">N. Saederup</name>
</author>
<author><name sortKey="Leemput, J" uniqKey="Leemput J">J. Leemput</name>
</author>
<author><name sortKey="Bigot, K" uniqKey="Bigot K">K. Bigot</name>
</author>
<author><name sortKey="Campisi, L" uniqKey="Campisi L">L. Campisi</name>
</author>
<author><name sortKey="Abitbol, M" uniqKey="Abitbol M">M. Abitbol</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Segura, E" uniqKey="Segura E">E. Segura</name>
</author>
<author><name sortKey="Touzot, M" uniqKey="Touzot M">M. Touzot</name>
</author>
<author><name sortKey="Bohineust, A" uniqKey="Bohineust A">A. Bohineust</name>
</author>
<author><name sortKey="Cappuccio, A" uniqKey="Cappuccio A">A. Cappuccio</name>
</author>
<author><name sortKey="Chiocchia, G" uniqKey="Chiocchia G">G. Chiocchia</name>
</author>
<author><name sortKey="Hosmalin, A" uniqKey="Hosmalin A">A. Hosmalin</name>
</author>
<author><name sortKey="Dalod, M" uniqKey="Dalod M">M. Dalod</name>
</author>
<author><name sortKey="Soumelis, V" uniqKey="Soumelis V">V. Soumelis</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shortman, K" uniqKey="Shortman K">K. Shortman</name>
</author>
<author><name sortKey="Liu, Y J" uniqKey="Liu Y">Y.J. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheong, C" uniqKey="Cheong C">C. Cheong</name>
</author>
<author><name sortKey="Matos, I" uniqKey="Matos I">I. Matos</name>
</author>
<author><name sortKey="Choi, J H" uniqKey="Choi J">J.H. Choi</name>
</author>
<author><name sortKey="Dandamudi, D B" uniqKey="Dandamudi D">D.B. Dandamudi</name>
</author>
<author><name sortKey="Shrestha, E" uniqKey="Shrestha E">E. Shrestha</name>
</author>
<author><name sortKey="Longhi, M P" uniqKey="Longhi M">M.P. Longhi</name>
</author>
<author><name sortKey="Jeffrey, K L" uniqKey="Jeffrey K">K.L. Jeffrey</name>
</author>
<author><name sortKey="Anthony, R M" uniqKey="Anthony R">R.M. Anthony</name>
</author>
<author><name sortKey="Kluger, C" uniqKey="Kluger C">C. Kluger</name>
</author>
<author><name sortKey="Nchinda, G" uniqKey="Nchinda G">G. Nchinda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Markov, O V" uniqKey="Markov O">O.V. Markov</name>
</author>
<author><name sortKey="Mironova, N L" uniqKey="Mironova N">N.L. Mironova</name>
</author>
<author><name sortKey="Vlasov, V V" uniqKey="Vlasov V">V.V. Vlasov</name>
</author>
<author><name sortKey="Zenkova, M A" uniqKey="Zenkova M">M.A. Zenkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Medel, B" uniqKey="Medel B">B. Medel</name>
</author>
<author><name sortKey="Costoya, C" uniqKey="Costoya C">C. Costoya</name>
</author>
<author><name sortKey="Fernandez, D" uniqKey="Fernandez D">D. Fernandez</name>
</author>
<author><name sortKey="Pereda, C" uniqKey="Pereda C">C. Pereda</name>
</author>
<author><name sortKey="Lladser, A" uniqKey="Lladser A">A. Lladser</name>
</author>
<author><name sortKey="Sauma, D" uniqKey="Sauma D">D. Sauma</name>
</author>
<author><name sortKey="Pacheco, R" uniqKey="Pacheco R">R. Pacheco</name>
</author>
<author><name sortKey="Iwawaki, T" uniqKey="Iwawaki T">T. Iwawaki</name>
</author>
<author><name sortKey="Salazar Onfray, F" uniqKey="Salazar Onfray F">F. Salazar-Onfray</name>
</author>
<author><name sortKey="Osorio, F" uniqKey="Osorio F">F. Osorio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Plantinga, M" uniqKey="Plantinga M">M. Plantinga</name>
</author>
<author><name sortKey="Guilliams, M" uniqKey="Guilliams M">M. Guilliams</name>
</author>
<author><name sortKey="Vanheerswynghels, M" uniqKey="Vanheerswynghels M">M. Vanheerswynghels</name>
</author>
<author><name sortKey="Deswarte, K" uniqKey="Deswarte K">K. Deswarte</name>
</author>
<author><name sortKey="Branco Madeira, F" uniqKey="Branco Madeira F">F. Branco-Madeira</name>
</author>
<author><name sortKey="Toussaint, W" uniqKey="Toussaint W">W. Toussaint</name>
</author>
<author><name sortKey="Vanhoutte, L" uniqKey="Vanhoutte L">L. Vanhoutte</name>
</author>
<author><name sortKey="Neyt, K" uniqKey="Neyt K">K. Neyt</name>
</author>
<author><name sortKey="Killeen, N" uniqKey="Killeen N">N. Killeen</name>
</author>
<author><name sortKey="Malissen, B" uniqKey="Malissen B">B. Malissen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Briseno, C G" uniqKey="Briseno C">C.G. Briseno</name>
</author>
<author><name sortKey="Haldar, M" uniqKey="Haldar M">M. Haldar</name>
</author>
<author><name sortKey="Kretzer, N M" uniqKey="Kretzer N">N.M. Kretzer</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name>
</author>
<author><name sortKey="Theisen, D J" uniqKey="Theisen D">D.J. Theisen</name>
</author>
<author><name sortKey="Kc, W" uniqKey="Kc W">W. Kc</name>
</author>
<author><name sortKey="Durai, V" uniqKey="Durai V">V. Durai</name>
</author>
<author><name sortKey="Grajales Reyes, G E" uniqKey="Grajales Reyes G">G.E. Grajales-Reyes</name>
</author>
<author><name sortKey="Iwata, A" uniqKey="Iwata A">A. Iwata</name>
</author>
<author><name sortKey="Bagadia, P" uniqKey="Bagadia P">P. Bagadia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahadevan, N R" uniqKey="Mahadevan N">N.R. Mahadevan</name>
</author>
<author><name sortKey="Anufreichik, V" uniqKey="Anufreichik V">V. Anufreichik</name>
</author>
<author><name sortKey="Rodvold, J J" uniqKey="Rodvold J">J.J. Rodvold</name>
</author>
<author><name sortKey="Chiu, K T" uniqKey="Chiu K">K.T. Chiu</name>
</author>
<author><name sortKey="Sepulveda, H" uniqKey="Sepulveda H">H. Sepulveda</name>
</author>
<author><name sortKey="Zanetti, M" uniqKey="Zanetti M">M. Zanetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohamed, E" uniqKey="Mohamed E">E. Mohamed</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name>
</author>
<author><name sortKey="Rodriguez, P C" uniqKey="Rodriguez P">P.C. Rodriguez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valladeau, J" uniqKey="Valladeau J">J. Valladeau</name>
</author>
<author><name sortKey="Dezutter Dambuyant, C" uniqKey="Dezutter Dambuyant C">C. Dezutter-Dambuyant</name>
</author>
<author><name sortKey="Saeland, S" uniqKey="Saeland S">S. Saeland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feinberg, H" uniqKey="Feinberg H">H. Feinberg</name>
</author>
<author><name sortKey="Taylor, M E" uniqKey="Taylor M">M.E. Taylor</name>
</author>
<author><name sortKey="Razi, N" uniqKey="Razi N">N. Razi</name>
</author>
<author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R. McBride</name>
</author>
<author><name sortKey="Knirel, Y A" uniqKey="Knirel Y">Y.A. Knirel</name>
</author>
<author><name sortKey="Graham, S A" uniqKey="Graham S">S.A. Graham</name>
</author>
<author><name sortKey="Drickamer, K" uniqKey="Drickamer K">K. Drickamer</name>
</author>
<author><name sortKey="Weis, W I" uniqKey="Weis W">W.I. Weis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furio, L" uniqKey="Furio L">L. Furio</name>
</author>
<author><name sortKey="Briotet, I" uniqKey="Briotet I">I. Briotet</name>
</author>
<author><name sortKey="Journeaux, A" uniqKey="Journeaux A">A. Journeaux</name>
</author>
<author><name sortKey="Billard, H" uniqKey="Billard H">H. Billard</name>
</author>
<author><name sortKey="Peguet Navarro, J" uniqKey="Peguet Navarro J">J. Peguet-Navarro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Furio, L" uniqKey="Furio L">L. Furio</name>
</author>
<author><name sortKey="Billard, H" uniqKey="Billard H">H. Billard</name>
</author>
<author><name sortKey="Valladeau, J" uniqKey="Valladeau J">J. Valladeau</name>
</author>
<author><name sortKey="Peguet Navarro, J" uniqKey="Peguet Navarro J">J. Peguet-Navarro</name>
</author>
<author><name sortKey="Berthier Vergnes, O" uniqKey="Berthier Vergnes O">O. Berthier-Vergnes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Igyart, B Z" uniqKey="Igyart B">B.Z. Igyártó</name>
</author>
<author><name sortKey="Haley, K" uniqKey="Haley K">K. Haley</name>
</author>
<author><name sortKey="Ortner, D" uniqKey="Ortner D">D. Ortner</name>
</author>
<author><name sortKey="Bobr, A" uniqKey="Bobr A">A. Bobr</name>
</author>
<author><name sortKey="Gerami Nejad, M" uniqKey="Gerami Nejad M">M. Gerami-Nejad</name>
</author>
<author><name sortKey="Edelson, B T" uniqKey="Edelson B">B.T. Edelson</name>
</author>
<author><name sortKey="Zurawski, S M" uniqKey="Zurawski S">S.M. Zurawski</name>
</author>
<author><name sortKey="Malissen, B" uniqKey="Malissen B">B. Malissen</name>
</author>
<author><name sortKey="Zurawski, G" uniqKey="Zurawski G">G. Zurawski</name>
</author>
<author><name sortKey="Berman, J" uniqKey="Berman J">J. Berman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fehres, C M" uniqKey="Fehres C">C.M. Fehres</name>
</author>
<author><name sortKey="Duinkerken, S" uniqKey="Duinkerken S">S. Duinkerken</name>
</author>
<author><name sortKey="Bruijns, S C" uniqKey="Bruijns S">S.C. Bruijns</name>
</author>
<author><name sortKey="Kalay, H" uniqKey="Kalay H">H. Kalay</name>
</author>
<author><name sortKey="Van Vliet, S J" uniqKey="Van Vliet S">S.J. van Vliet</name>
</author>
<author><name sortKey="Ambrosini, M" uniqKey="Ambrosini M">M. Ambrosini</name>
</author>
<author><name sortKey="De Gruijl, T D" uniqKey="De Gruijl T">T.D. de Gruijl</name>
</author>
<author><name sortKey="Unger, W W" uniqKey="Unger W">W.W. Unger</name>
</author>
<author><name sortKey="Garcia Vallejo, J J" uniqKey="Garcia Vallejo J">J.J. Garcia-Vallejo</name>
</author>
<author><name sortKey="Van Kooyk, Y" uniqKey="Van Kooyk Y">Y. van Kooyk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Eeffe, M" uniqKey="O Eeffe M">M. O’Keeffe</name>
</author>
<author><name sortKey="Mok, W H" uniqKey="Mok W">W.H. Mok</name>
</author>
<author><name sortKey="Radford, K" uniqKey="Radford K">K. Radford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wculek, S K" uniqKey="Wculek S">S.K. Wculek</name>
</author>
<author><name sortKey="Cueto, F J" uniqKey="Cueto F">F.J. Cueto</name>
</author>
<author><name sortKey="Mujal, A M" uniqKey="Mujal A">A.M. Mujal</name>
</author>
<author><name sortKey="Melero, I" uniqKey="Melero I">I. Melero</name>
</author>
<author><name sortKey="Krummel, M F" uniqKey="Krummel M">M.F. Krummel</name>
</author>
<author><name sortKey="Sancho, D" uniqKey="Sancho D">D. Sancho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Constantino, J" uniqKey="Constantino J">J. Constantino</name>
</author>
<author><name sortKey="Gomes, C" uniqKey="Gomes C">C. Gomes</name>
</author>
<author><name sortKey="Falcao, A" uniqKey="Falcao A">A. Falcão</name>
</author>
<author><name sortKey="Neves, B M" uniqKey="Neves B">B.M. Neves</name>
</author>
<author><name sortKey="Cruz, M T" uniqKey="Cruz M">M.T. Cruz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schreibelt, G" uniqKey="Schreibelt G">G. Schreibelt</name>
</author>
<author><name sortKey="Bol, K F" uniqKey="Bol K">K.F. Bol</name>
</author>
<author><name sortKey="Westdorp, H" uniqKey="Westdorp H">H. Westdorp</name>
</author>
<author><name sortKey="Wimmers, F" uniqKey="Wimmers F">F. Wimmers</name>
</author>
<author><name sortKey="Aarntzen, E H" uniqKey="Aarntzen E">E.H. Aarntzen</name>
</author>
<author><name sortKey="Duiveman De Boer, T" uniqKey="Duiveman De Boer T">T. Duiveman-de Boer</name>
</author>
<author><name sortKey="Van De Rakt, M W" uniqKey="Van De Rakt M">M.W. van de Rakt</name>
</author>
<author><name sortKey="Scharenborg, N M" uniqKey="Scharenborg N">N.M. Scharenborg</name>
</author>
<author><name sortKey="De Boer, A J" uniqKey="De Boer A">A.J. de Boer</name>
</author>
<author><name sortKey="Pots, J M" uniqKey="Pots J">J.M. Pots</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hildner, K" uniqKey="Hildner K">K. Hildner</name>
</author>
<author><name sortKey="Edelson, B T" uniqKey="Edelson B">B.T. Edelson</name>
</author>
<author><name sortKey="Purtha, W E" uniqKey="Purtha W">W.E. Purtha</name>
</author>
<author><name sortKey="Diamond, M" uniqKey="Diamond M">M. Diamond</name>
</author>
<author><name sortKey="Matsushita, H" uniqKey="Matsushita H">H. Matsushita</name>
</author>
<author><name sortKey="Kohyama, M" uniqKey="Kohyama M">M. Kohyama</name>
</author>
<author><name sortKey="Calderon, B" uniqKey="Calderon B">B. Calderon</name>
</author>
<author><name sortKey="Schraml, B U" uniqKey="Schraml B">B.U. Schraml</name>
</author>
<author><name sortKey="Unanue, E R" uniqKey="Unanue E">E.R. Unanue</name>
</author>
<author><name sortKey="Diamond, M S" uniqKey="Diamond M">M.S. Diamond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sachamitr, P" uniqKey="Sachamitr P">P. Sachamitr</name>
</author>
<author><name sortKey="Leishman, A J" uniqKey="Leishman A">A.J. Leishman</name>
</author>
<author><name sortKey="Davies, T J" uniqKey="Davies T">T.J. Davies</name>
</author>
<author><name sortKey="Fairchild, P J" uniqKey="Fairchild P">P.J. Fairchild</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Apter, D" uniqKey="Apter D">D. Apter</name>
</author>
<author><name sortKey="Wheeler, C M" uniqKey="Wheeler C">C.M. Wheeler</name>
</author>
<author><name sortKey="Paavonen, J" uniqKey="Paavonen J">J. Paavonen</name>
</author>
<author><name sortKey="Naud, P" uniqKey="Naud P">P. Naud</name>
</author>
<author><name sortKey="Salmer N, J" uniqKey="Salmer N J">J. Salmerón</name>
</author>
<author><name sortKey="Wheeler, C M" uniqKey="Wheeler C">C.M. Wheeler</name>
</author>
<author><name sortKey="Chow, S N" uniqKey="Chow S">S.N. Chow</name>
</author>
<author><name sortKey="Apter, D" uniqKey="Apter D">D. Apter</name>
</author>
<author><name sortKey="Kitchener, H" uniqKey="Kitchener H">H. Kitchener</name>
</author>
<author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X. Castellsague</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kantoff, P W" uniqKey="Kantoff P">P.W. Kantoff</name>
</author>
<author><name sortKey="Higano, C S" uniqKey="Higano C">C.S. Higano</name>
</author>
<author><name sortKey="Shore, N D" uniqKey="Shore N">N.D. Shore</name>
</author>
<author><name sortKey="Berger, E R" uniqKey="Berger E">E.R. Berger</name>
</author>
<author><name sortKey="Small, E J" uniqKey="Small E">E.J. Small</name>
</author>
<author><name sortKey="Penson, D F" uniqKey="Penson D">D.F. Penson</name>
</author>
<author><name sortKey="Redfern, C H" uniqKey="Redfern C">C.H. Redfern</name>
</author>
<author><name sortKey="Ferrari, A C" uniqKey="Ferrari A">A.C. Ferrari</name>
</author>
<author><name sortKey="Dreicer, R" uniqKey="Dreicer R">R. Dreicer</name>
</author>
<author><name sortKey="Sims, R B" uniqKey="Sims R">R.B. Sims</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andersen, M H" uniqKey="Andersen M">M.H. Andersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mant, A" uniqKey="Mant A">A. Mant</name>
</author>
<author><name sortKey="Chinnery, F" uniqKey="Chinnery F">F. Chinnery</name>
</author>
<author><name sortKey="Elliott, T" uniqKey="Elliott T">T. Elliott</name>
</author>
<author><name sortKey="Williams, A P" uniqKey="Williams A">A.P. Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kovacsovics Bankowski, M" uniqKey="Kovacsovics Bankowski M">M. Kovacsovics-Bankowski</name>
</author>
<author><name sortKey="Rock, K L" uniqKey="Rock K">K.L. Rock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ackerman, A L" uniqKey="Ackerman A">A.L. Ackerman</name>
</author>
<author><name sortKey="Kyritsis, C" uniqKey="Kyritsis C">C. Kyritsis</name>
</author>
<author><name sortKey="Tampe, R" uniqKey="Tampe R">R. Tampé</name>
</author>
<author><name sortKey="Cresswell, P" uniqKey="Cresswell P">P. Cresswell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palmowski, M J" uniqKey="Palmowski M">M.J. Palmowski</name>
</author>
<author><name sortKey="Gileadi, U" uniqKey="Gileadi U">U. Gileadi</name>
</author>
<author><name sortKey="Salio, M" uniqKey="Salio M">M. Salio</name>
</author>
<author><name sortKey="Gallimore, A" uniqKey="Gallimore A">A. Gallimore</name>
</author>
<author><name sortKey="Millrain, M" uniqKey="Millrain M">M. Millrain</name>
</author>
<author><name sortKey="James, E" uniqKey="James E">E. James</name>
</author>
<author><name sortKey="Addey, C" uniqKey="Addey C">C. Addey</name>
</author>
<author><name sortKey="Scott, D" uniqKey="Scott D">D. Scott</name>
</author>
<author><name sortKey="Dyson, J" uniqKey="Dyson J">J. Dyson</name>
</author>
<author><name sortKey="Simpson, E" uniqKey="Simpson E">E. Simpson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Embgenbroich, M" uniqKey="Embgenbroich M">M. Embgenbroich</name>
</author>
<author><name sortKey="Burgdorf, S" uniqKey="Burgdorf S">S. Burgdorf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gros, M" uniqKey="Gros M">M. Gros</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, A Y" uniqKey="Huang A">A.Y. Huang</name>
</author>
<author><name sortKey="Bruce, A T" uniqKey="Bruce A">A.T. Bruce</name>
</author>
<author><name sortKey="Pardoll, D M" uniqKey="Pardoll D">D.M. Pardoll</name>
</author>
<author><name sortKey="Levitsky, H I" uniqKey="Levitsky H">H.I. Levitsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kloetzel, P M" uniqKey="Kloetzel P">P.M. Kloetzel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A. Rodriguez</name>
</author>
<author><name sortKey="Regnault, A" uniqKey="Regnault A">A. Regnault</name>
</author>
<author><name sortKey="Kleijmeer, M" uniqKey="Kleijmeer M">M. Kleijmeer</name>
</author>
<author><name sortKey="Ricciardi Castagnoli, P" uniqKey="Ricciardi Castagnoli P">P. Ricciardi-Castagnoli</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, L" uniqKey="Shen L">L. Shen</name>
</author>
<author><name sortKey="Sigal, L J" uniqKey="Sigal L">L.J. Sigal</name>
</author>
<author><name sortKey="Boes, M" uniqKey="Boes M">M. Boes</name>
</author>
<author><name sortKey="Rock, K L" uniqKey="Rock K">K.L. Rock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jia, Y" uniqKey="Jia Y">Y. Jia</name>
</author>
<author><name sortKey="Omri, A" uniqKey="Omri A">A. Omri</name>
</author>
<author><name sortKey="Krishnan, L" uniqKey="Krishnan L">L. Krishnan</name>
</author>
<author><name sortKey="Mccluskie, M J" uniqKey="Mccluskie M">M.J. McCluskie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belz, G T" uniqKey="Belz G">G.T. Belz</name>
</author>
<author><name sortKey="Behrens, G M" uniqKey="Behrens G">G.M. Behrens</name>
</author>
<author><name sortKey="Smith, C M" uniqKey="Smith C">C.M. Smith</name>
</author>
<author><name sortKey="Miller, J F" uniqKey="Miller J">J.F. Miller</name>
</author>
<author><name sortKey="Jones, C" uniqKey="Jones C">C. Jones</name>
</author>
<author><name sortKey="Lejon, K" uniqKey="Lejon K">K. Lejon</name>
</author>
<author><name sortKey="Fathman, C G" uniqKey="Fathman C">C.G. Fathman</name>
</author>
<author><name sortKey="Mueller, S N" uniqKey="Mueller S">S.N. Mueller</name>
</author>
<author><name sortKey="Shortman, K" uniqKey="Shortman K">K. Shortman</name>
</author>
<author><name sortKey="Carbone, F R" uniqKey="Carbone F">F.R. Carbone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sengupta, D" uniqKey="Sengupta D">D. Sengupta</name>
</author>
<author><name sortKey="Graham, M" uniqKey="Graham M">M. Graham</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
<author><name sortKey="Cresswell, P" uniqKey="Cresswell P">P. Cresswell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dingjan, I" uniqKey="Dingjan I">I. Dingjan</name>
</author>
<author><name sortKey="Verboogen, D R" uniqKey="Verboogen D">D.R. Verboogen</name>
</author>
<author><name sortKey="Paardekooper, L M" uniqKey="Paardekooper L">L.M. Paardekooper</name>
</author>
<author><name sortKey="Revelo, N H" uniqKey="Revelo N">N.H. Revelo</name>
</author>
<author><name sortKey="Sittig, S P" uniqKey="Sittig S">S.P. Sittig</name>
</author>
<author><name sortKey="Visser, L J" uniqKey="Visser L">L.J. Visser</name>
</author>
<author><name sortKey="Mollard, G F" uniqKey="Mollard G">G.F. Mollard</name>
</author>
<author><name sortKey="Henriet, S S" uniqKey="Henriet S">S.S. Henriet</name>
</author>
<author><name sortKey="Figdor, C G" uniqKey="Figdor C">C.G. Figdor</name>
</author>
<author><name sortKey="Ter Beest, M" uniqKey="Ter Beest M">M. Ter Beest</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imai, J" uniqKey="Imai J">J. Imai</name>
</author>
<author><name sortKey="Otani, M" uniqKey="Otani M">M. Otani</name>
</author>
<author><name sortKey="Sakai, T" uniqKey="Sakai T">T. Sakai</name>
</author>
<author><name sortKey="Hatta, S" uniqKey="Hatta S">S. Hatta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zehner, M" uniqKey="Zehner M">M. Zehner</name>
</author>
<author><name sortKey="Marschall, A L" uniqKey="Marschall A">A.L. Marschall</name>
</author>
<author><name sortKey="Bos, E" uniqKey="Bos E">E. Bos</name>
</author>
<author><name sortKey="Schloetel, J G" uniqKey="Schloetel J">J.G. Schloetel</name>
</author>
<author><name sortKey="Kreer, C" uniqKey="Kreer C">C. Kreer</name>
</author>
<author><name sortKey="Fehrenschild, D" uniqKey="Fehrenschild D">D. Fehrenschild</name>
</author>
<author><name sortKey="Limmer, A" uniqKey="Limmer A">A. Limmer</name>
</author>
<author><name sortKey="Ossendorp, F" uniqKey="Ossendorp F">F. Ossendorp</name>
</author>
<author><name sortKey="Lang, T" uniqKey="Lang T">T. Lang</name>
</author>
<author><name sortKey="Koster, A J" uniqKey="Koster A">A.J. Koster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menager, J" uniqKey="Menager J">J. Menager</name>
</author>
<author><name sortKey="Ebstein, F" uniqKey="Ebstein F">F. Ebstein</name>
</author>
<author><name sortKey="Oger, R" uniqKey="Oger R">R. Oger</name>
</author>
<author><name sortKey="Hulin, P" uniqKey="Hulin P">P. Hulin</name>
</author>
<author><name sortKey="Nedellec, S" uniqKey="Nedellec S">S. Nedellec</name>
</author>
<author><name sortKey="Duverger, E" uniqKey="Duverger E">E. Duverger</name>
</author>
<author><name sortKey="Lehmann, A" uniqKey="Lehmann A">A. Lehmann</name>
</author>
<author><name sortKey="Kloetzel, P M" uniqKey="Kloetzel P">P.M. Kloetzel</name>
</author>
<author><name sortKey="Jotereau, F" uniqKey="Jotereau F">F. Jotereau</name>
</author>
<author><name sortKey="Guilloux, Y" uniqKey="Guilloux Y">Y. Guilloux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delamarre, L" uniqKey="Delamarre L">L. Delamarre</name>
</author>
<author><name sortKey="Pack, M" uniqKey="Pack M">M. Pack</name>
</author>
<author><name sortKey="Chang, H" uniqKey="Chang H">H. Chang</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I. Mellman</name>
</author>
<author><name sortKey="Trombetta, E S" uniqKey="Trombetta E">E.S. Trombetta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lennon Dumenil, A M" uniqKey="Lennon Dumenil A">A.M. Lennon-Dumenil</name>
</author>
<author><name sortKey="Bakker, A H" uniqKey="Bakker A">A.H. Bakker</name>
</author>
<author><name sortKey="Wolf Bryant, P" uniqKey="Wolf Bryant P">P. Wolf-Bryant</name>
</author>
<author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name>
</author>
<author><name sortKey="Lagaudriere Gesbert, C" uniqKey="Lagaudriere Gesbert C">C. Lagaudriere-Gesbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savina, A" uniqKey="Savina A">A. Savina</name>
</author>
<author><name sortKey="Jancic, C" uniqKey="Jancic C">C. Jancic</name>
</author>
<author><name sortKey="Hugues, S" uniqKey="Hugues S">S. Hugues</name>
</author>
<author><name sortKey="Guermonprez, P" uniqKey="Guermonprez P">P. Guermonprez</name>
</author>
<author><name sortKey="Vargas, P" uniqKey="Vargas P">P. Vargas</name>
</author>
<author><name sortKey="Moura, I C" uniqKey="Moura I">I.C. Moura</name>
</author>
<author><name sortKey="Lennon Dumenil, A M" uniqKey="Lennon Dumenil A">A.M. Lennon-Duménil</name>
</author>
<author><name sortKey="Seabra, M C" uniqKey="Seabra M">M.C. Seabra</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Savina, A" uniqKey="Savina A">A. Savina</name>
</author>
<author><name sortKey="Peres, A" uniqKey="Peres A">A. Peres</name>
</author>
<author><name sortKey="Cebrian, I" uniqKey="Cebrian I">I. Cebrian</name>
</author>
<author><name sortKey="Carmo, N" uniqKey="Carmo N">N. Carmo</name>
</author>
<author><name sortKey="Moita, C" uniqKey="Moita C">C. Moita</name>
</author>
<author><name sortKey="Hacohen, N" uniqKey="Hacohen N">N. Hacohen</name>
</author>
<author><name sortKey="Moita, L F" uniqKey="Moita L">L.F. Moita</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Claus, V" uniqKey="Claus V">V. Claus</name>
</author>
<author><name sortKey="Jahraus, A" uniqKey="Jahraus A">A. Jahraus</name>
</author>
<author><name sortKey="Tjelle, T" uniqKey="Tjelle T">T. Tjelle</name>
</author>
<author><name sortKey="Berg, T" uniqKey="Berg T">T. Berg</name>
</author>
<author><name sortKey="Kirschke, H" uniqKey="Kirschke H">H. Kirschke</name>
</author>
<author><name sortKey="Faulstich, H" uniqKey="Faulstich H">H. Faulstich</name>
</author>
<author><name sortKey="Griffiths, G" uniqKey="Griffiths G">G. Griffiths</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trombetta, E S" uniqKey="Trombetta E">E.S. Trombetta</name>
</author>
<author><name sortKey="Ebersold, M" uniqKey="Ebersold M">M. Ebersold</name>
</author>
<author><name sortKey="Garrett, W" uniqKey="Garrett W">W. Garrett</name>
</author>
<author><name sortKey="Pypaert, M" uniqKey="Pypaert M">M. Pypaert</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I. Mellman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forgac, M" uniqKey="Forgac M">M. Forgac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liberman, R" uniqKey="Liberman R">R. Liberman</name>
</author>
<author><name sortKey="Bond, S" uniqKey="Bond S">S. Bond</name>
</author>
<author><name sortKey="Shainheit, M G" uniqKey="Shainheit M">M.G. Shainheit</name>
</author>
<author><name sortKey="Stadecker, M J" uniqKey="Stadecker M">M.J. Stadecker</name>
</author>
<author><name sortKey="Forgac, M" uniqKey="Forgac M">M. Forgac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gerriets, V A" uniqKey="Gerriets V">V.A. Gerriets</name>
</author>
<author><name sortKey="Kishton, R J" uniqKey="Kishton R">R.J. Kishton</name>
</author>
<author><name sortKey="Johnson, M O" uniqKey="Johnson M">M.O. Johnson</name>
</author>
<author><name sortKey="Cohen, S" uniqKey="Cohen S">S. Cohen</name>
</author>
<author><name sortKey="Siska, P J" uniqKey="Siska P">P.J. Siska</name>
</author>
<author><name sortKey="Nichols, A G" uniqKey="Nichols A">A.G. Nichols</name>
</author>
<author><name sortKey="Warmoes, M O" uniqKey="Warmoes M">M.O. Warmoes</name>
</author>
<author><name sortKey="De Cubas, A A" uniqKey="De Cubas A">A.A. de Cubas</name>
</author>
<author><name sortKey="Maciver, N J" uniqKey="Maciver N">N.J. MacIver</name>
</author>
<author><name sortKey="Locasale, J W" uniqKey="Locasale J">J.W. Locasale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nguyen, G T" uniqKey="Nguyen G">G.T. Nguyen</name>
</author>
<author><name sortKey="Green, E R" uniqKey="Green E">E.R. Green</name>
</author>
<author><name sortKey="Mecsas, J" uniqKey="Mecsas J">J. Mecsas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jancic, C" uniqKey="Jancic C">C. Jancic</name>
</author>
<author><name sortKey="Savina, A" uniqKey="Savina A">A. Savina</name>
</author>
<author><name sortKey="Wasmeier, C" uniqKey="Wasmeier C">C. Wasmeier</name>
</author>
<author><name sortKey="Tolmachova, T" uniqKey="Tolmachova T">T. Tolmachova</name>
</author>
<author><name sortKey="El Benna, J" uniqKey="El Benna J">J. El-Benna</name>
</author>
<author><name sortKey="Dang, P M" uniqKey="Dang P">P.M. Dang</name>
</author>
<author><name sortKey="Pascolo, S" uniqKey="Pascolo S">S. Pascolo</name>
</author>
<author><name sortKey="Gougerot Pocdalo, M A" uniqKey="Gougerot Pocdalo M">M.A. Gougerot-Pocdalo</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G. Raposo</name>
</author>
<author><name sortKey="Seabra, M C" uniqKey="Seabra M">M.C. Seabra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paardekooper, L M" uniqKey="Paardekooper L">L.M. Paardekooper</name>
</author>
<author><name sortKey="Dingjan, I" uniqKey="Dingjan I">I. Dingjan</name>
</author>
<author><name sortKey="Linders, P T A" uniqKey="Linders P">P.T.A. Linders</name>
</author>
<author><name sortKey="Staal, A H J" uniqKey="Staal A">A.H.J. Staal</name>
</author>
<author><name sortKey="Cristescu, S M" uniqKey="Cristescu S">S.M. Cristescu</name>
</author>
<author><name sortKey="Verberk, W" uniqKey="Verberk W">W. Verberk</name>
</author>
<author><name sortKey="Van Den Bogaart, G" uniqKey="Van Den Bogaart G">G. van den Bogaart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dingjan, I" uniqKey="Dingjan I">I. Dingjan</name>
</author>
<author><name sortKey="Paardekooper, L M" uniqKey="Paardekooper L">L.M. Paardekooper</name>
</author>
<author><name sortKey="Verboogen, D R J" uniqKey="Verboogen D">D.R.J. Verboogen</name>
</author>
<author><name sortKey="Von Mollard, G F" uniqKey="Von Mollard G">G.F. von Mollard</name>
</author>
<author><name sortKey="Ter Beest, M" uniqKey="Ter Beest M">M. Ter Beest</name>
</author>
<author><name sortKey="Van Den Bogaart, G" uniqKey="Van Den Bogaart G">G. van den Bogaart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matheoud, D" uniqKey="Matheoud D">D. Matheoud</name>
</author>
<author><name sortKey="Moradin, N" uniqKey="Moradin N">N. Moradin</name>
</author>
<author><name sortKey="Bellemare Pelletier, A" uniqKey="Bellemare Pelletier A">A. Bellemare-Pelletier</name>
</author>
<author><name sortKey="Shio, M T" uniqKey="Shio M">M.T. Shio</name>
</author>
<author><name sortKey="Hong, W J" uniqKey="Hong W">W.J. Hong</name>
</author>
<author><name sortKey="Olivier, M" uniqKey="Olivier M">M. Olivier</name>
</author>
<author><name sortKey="Gagnon, E" uniqKey="Gagnon E">E. Gagnon</name>
</author>
<author><name sortKey="Desjardins, M" uniqKey="Desjardins M">M. Desjardins</name>
</author>
<author><name sortKey="Descoteaux, A" uniqKey="Descoteaux A">A. Descoteaux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baptista, M A" uniqKey="Baptista M">M.A. Baptista</name>
</author>
<author><name sortKey="Keszei, M" uniqKey="Keszei M">M. Keszei</name>
</author>
<author><name sortKey="Oliveira, M" uniqKey="Oliveira M">M. Oliveira</name>
</author>
<author><name sortKey="Sunahara, K K" uniqKey="Sunahara K">K.K. Sunahara</name>
</author>
<author><name sortKey="Andersson, J" uniqKey="Andersson J">J. Andersson</name>
</author>
<author><name sortKey="Dahlberg, C I" uniqKey="Dahlberg C">C.I. Dahlberg</name>
</author>
<author><name sortKey="Worth, A J" uniqKey="Worth A">A.J. Worth</name>
</author>
<author><name sortKey="Lieden, A" uniqKey="Lieden A">A. Lieden</name>
</author>
<author><name sortKey="Kuo, I C" uniqKey="Kuo I">I.C. Kuo</name>
</author>
<author><name sortKey="Wallin, R P" uniqKey="Wallin R">R.P. Wallin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name>
</author>
<author><name sortKey="Gu, Y" uniqKey="Gu Y">Y. Gu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Zhao, D" uniqKey="Zhao D">D. Zhao</name>
</author>
<author><name sortKey="Cao, X" uniqKey="Cao X">X. Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stegmann, T" uniqKey="Stegmann T">T. Stegmann</name>
</author>
<author><name sortKey="Booy, F P" uniqKey="Booy F">F.P. Booy</name>
</author>
<author><name sortKey="Wilschut, J" uniqKey="Wilschut J">J. Wilschut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roche, S" uniqKey="Roche S">S. Roche</name>
</author>
<author><name sortKey="Gaudin, Y" uniqKey="Gaudin Y">Y. Gaudin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Komala Sari, T" uniqKey="Komala Sari T">T. Komala Sari</name>
</author>
<author><name sortKey="Pritchard, S M" uniqKey="Pritchard S">S.M. Pritchard</name>
</author>
<author><name sortKey="Cunha, C W" uniqKey="Cunha C">C.W. Cunha</name>
</author>
<author><name sortKey="Wudiri, G A" uniqKey="Wudiri G">G.A. Wudiri</name>
</author>
<author><name sortKey="Laws, E I" uniqKey="Laws E">E.I. Laws</name>
</author>
<author><name sortKey="Aguilar, H C" uniqKey="Aguilar H">H.C. Aguilar</name>
</author>
<author><name sortKey="Taus, N S" uniqKey="Taus N">N.S. Taus</name>
</author>
<author><name sortKey="Nicola, A V" uniqKey="Nicola A">A.V. Nicola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gil Torregrosa, B C" uniqKey="Gil Torregrosa B">B.C. Gil-Torregrosa</name>
</author>
<author><name sortKey="Lennon Dumenil, A M" uniqKey="Lennon Dumenil A">A.M. Lennon-Duménil</name>
</author>
<author><name sortKey="Kessler, B" uniqKey="Kessler B">B. Kessler</name>
</author>
<author><name sortKey="Guermonprez, P" uniqKey="Guermonprez P">P. Guermonprez</name>
</author>
<author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name>
</author>
<author><name sortKey="Fruci, D" uniqKey="Fruci D">D. Fruci</name>
</author>
<author><name sortKey="Van Endert, P" uniqKey="Van Endert P">P. van Endert</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belizaire, R" uniqKey="Belizaire R">R. Belizaire</name>
</author>
<author><name sortKey="Unanue, E R" uniqKey="Unanue E">E.R. Unanue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Accapezzato, D" uniqKey="Accapezzato D">D. Accapezzato</name>
</author>
<author><name sortKey="Visco, V" uniqKey="Visco V">V. Visco</name>
</author>
<author><name sortKey="Francavilla, V" uniqKey="Francavilla V">V. Francavilla</name>
</author>
<author><name sortKey="Molette, C" uniqKey="Molette C">C. Molette</name>
</author>
<author><name sortKey="Donato, T" uniqKey="Donato T">T. Donato</name>
</author>
<author><name sortKey="Paroli, M" uniqKey="Paroli M">M. Paroli</name>
</author>
<author><name sortKey="Mondelli, M U" uniqKey="Mondelli M">M.U. Mondelli</name>
</author>
<author><name sortKey="Doria, M" uniqKey="Doria M">M. Doria</name>
</author>
<author><name sortKey="Torrisi, M R" uniqKey="Torrisi M">M.R. Torrisi</name>
</author>
<author><name sortKey="Barnaba, V" uniqKey="Barnaba V">V. Barnaba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chatterjee, B" uniqKey="Chatterjee B">B. Chatterjee</name>
</author>
<author><name sortKey="Smed Sorensen, A" uniqKey="Smed Sorensen A">A. Smed-Sörensen</name>
</author>
<author><name sortKey="Cohn, L" uniqKey="Cohn L">L. Cohn</name>
</author>
<author><name sortKey="Chalouni, C" uniqKey="Chalouni C">C. Chalouni</name>
</author>
<author><name sortKey="Vandlen, R" uniqKey="Vandlen R">R. Vandlen</name>
</author>
<author><name sortKey="Lee, B C" uniqKey="Lee B">B.C. Lee</name>
</author>
<author><name sortKey="Widger, J" uniqKey="Widger J">J. Widger</name>
</author>
<author><name sortKey="Keler, T" uniqKey="Keler T">T. Keler</name>
</author>
<author><name sortKey="Delamarre, L" uniqKey="Delamarre L">L. Delamarre</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I. Mellman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y. Han</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D. Liu</name>
</author>
<author><name sortKey="Ma, G" uniqKey="Ma G">G. Ma</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C. Li</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name>
</author>
<author><name sortKey="Kong, D" uniqKey="Kong D">D. Kong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burgdorf, S" uniqKey="Burgdorf S">S. Burgdorf</name>
</author>
<author><name sortKey="Kautz, A" uniqKey="Kautz A">A. Kautz</name>
</author>
<author><name sortKey="Bohnert, V" uniqKey="Bohnert V">V. Böhnert</name>
</author>
<author><name sortKey="Knolle, P A" uniqKey="Knolle P">P.A. Knolle</name>
</author>
<author><name sortKey="Kurts, C" uniqKey="Kurts C">C. Kurts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tacken, P J" uniqKey="Tacken P">P.J. Tacken</name>
</author>
<author><name sortKey="De Vries, I J" uniqKey="De Vries I">I.J. de Vries</name>
</author>
<author><name sortKey="Gijzen, K" uniqKey="Gijzen K">K. Gijzen</name>
</author>
<author><name sortKey="Joosten, B" uniqKey="Joosten B">B. Joosten</name>
</author>
<author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name>
</author>
<author><name sortKey="Rother, R P" uniqKey="Rother R">R.P. Rother</name>
</author>
<author><name sortKey="Faas, S J" uniqKey="Faas S">S.J. Faas</name>
</author>
<author><name sortKey="Punt, C J" uniqKey="Punt C">C.J. Punt</name>
</author>
<author><name sortKey="Torensma, R" uniqKey="Torensma R">R. Torensma</name>
</author>
<author><name sortKey="Adema, G J" uniqKey="Adema G">G.J. Adema</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tacken, P J" uniqKey="Tacken P">P.J. Tacken</name>
</author>
<author><name sortKey="Ginter, W" uniqKey="Ginter W">W. Ginter</name>
</author>
<author><name sortKey="Berod, L" uniqKey="Berod L">L. Berod</name>
</author>
<author><name sortKey="Cruz, L J" uniqKey="Cruz L">L.J. Cruz</name>
</author>
<author><name sortKey="Joosten, B" uniqKey="Joosten B">B. Joosten</name>
</author>
<author><name sortKey="Sparwasser, T" uniqKey="Sparwasser T">T. Sparwasser</name>
</author>
<author><name sortKey="Figdor, C G" uniqKey="Figdor C">C.G. Figdor</name>
</author>
<author><name sortKey="Cambi, A" uniqKey="Cambi A">A. Cambi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cohn, L" uniqKey="Cohn L">L. Cohn</name>
</author>
<author><name sortKey="Chatterjee, B" uniqKey="Chatterjee B">B. Chatterjee</name>
</author>
<author><name sortKey="Esselborn, F" uniqKey="Esselborn F">F. Esselborn</name>
</author>
<author><name sortKey="Smed Sorensen, A" uniqKey="Smed Sorensen A">A. Smed-Sörensen</name>
</author>
<author><name sortKey="Nakamura, N" uniqKey="Nakamura N">N. Nakamura</name>
</author>
<author><name sortKey="Chalouni, C" uniqKey="Chalouni C">C. Chalouni</name>
</author>
<author><name sortKey="Lee, B C" uniqKey="Lee B">B.C. Lee</name>
</author>
<author><name sortKey="Vandlen, R" uniqKey="Vandlen R">R. Vandlen</name>
</author>
<author><name sortKey="Keler, T" uniqKey="Keler T">T. Keler</name>
</author>
<author><name sortKey="Lauer, P" uniqKey="Lauer P">P. Lauer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gagnon, E" uniqKey="Gagnon E">E. Gagnon</name>
</author>
<author><name sortKey="Duclos, S" uniqKey="Duclos S">S. Duclos</name>
</author>
<author><name sortKey="Rondeau, C" uniqKey="Rondeau C">C. Rondeau</name>
</author>
<author><name sortKey="Chevet, E" uniqKey="Chevet E">E. Chevet</name>
</author>
<author><name sortKey="Cameron, P H" uniqKey="Cameron P">P.H. Cameron</name>
</author>
<author><name sortKey="Steele Mortimer, O" uniqKey="Steele Mortimer O">O. Steele-Mortimer</name>
</author>
<author><name sortKey="Paiement, J" uniqKey="Paiement J">J. Paiement</name>
</author>
<author><name sortKey="Bergeron, J J" uniqKey="Bergeron J">J.J. Bergeron</name>
</author>
<author><name sortKey="Desjardins, M" uniqKey="Desjardins M">M. Desjardins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Houde, M" uniqKey="Houde M">M. Houde</name>
</author>
<author><name sortKey="Bertholet, S" uniqKey="Bertholet S">S. Bertholet</name>
</author>
<author><name sortKey="Gagnon, E" uniqKey="Gagnon E">E. Gagnon</name>
</author>
<author><name sortKey="Brunet, S" uniqKey="Brunet S">S. Brunet</name>
</author>
<author><name sortKey="Goyette, G" uniqKey="Goyette G">G. Goyette</name>
</author>
<author><name sortKey="Laplante, A" uniqKey="Laplante A">A. Laplante</name>
</author>
<author><name sortKey="Princiotta, M F" uniqKey="Princiotta M">M.F. Princiotta</name>
</author>
<author><name sortKey="Thibault, P" uniqKey="Thibault P">P. Thibault</name>
</author>
<author><name sortKey="Sacks, D" uniqKey="Sacks D">D. Sacks</name>
</author>
<author><name sortKey="Desjardins, M" uniqKey="Desjardins M">M. Desjardins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guermonprez, P" uniqKey="Guermonprez P">P. Guermonprez</name>
</author>
<author><name sortKey="Saveanu, L" uniqKey="Saveanu L">L. Saveanu</name>
</author>
<author><name sortKey="Kleijmeer, M" uniqKey="Kleijmeer M">M. Kleijmeer</name>
</author>
<author><name sortKey="Davoust, J" uniqKey="Davoust J">J. Davoust</name>
</author>
<author><name sortKey="Van Endert, P" uniqKey="Van Endert P">P. Van Endert</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eden, E R" uniqKey="Eden E">E.R. Eden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cebrian, I" uniqKey="Cebrian I">I. Cebrian</name>
</author>
<author><name sortKey="Visentin, G" uniqKey="Visentin G">G. Visentin</name>
</author>
<author><name sortKey="Blanchard, N" uniqKey="Blanchard N">N. Blanchard</name>
</author>
<author><name sortKey="Jouve, M" uniqKey="Jouve M">M. Jouve</name>
</author>
<author><name sortKey="Bobard, A" uniqKey="Bobard A">A. Bobard</name>
</author>
<author><name sortKey="Moita, C" uniqKey="Moita C">C. Moita</name>
</author>
<author><name sortKey="Enninga, J" uniqKey="Enninga J">J. Enninga</name>
</author>
<author><name sortKey="Moita, L F" uniqKey="Moita L">L.F. Moita</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
<author><name sortKey="Savina, A" uniqKey="Savina A">A. Savina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nair Gupta, P" uniqKey="Nair Gupta P">P. Nair-Gupta</name>
</author>
<author><name sortKey="Baccarini, A" uniqKey="Baccarini A">A. Baccarini</name>
</author>
<author><name sortKey="Tung, N" uniqKey="Tung N">N. Tung</name>
</author>
<author><name sortKey="Seyffer, F" uniqKey="Seyffer F">F. Seyffer</name>
</author>
<author><name sortKey="Florey, O" uniqKey="Florey O">O. Florey</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name>
</author>
<author><name sortKey="Banerjee, M" uniqKey="Banerjee M">M. Banerjee</name>
</author>
<author><name sortKey="Overholtzer, M" uniqKey="Overholtzer M">M. Overholtzer</name>
</author>
<author><name sortKey="Roche, P A" uniqKey="Roche P">P.A. Roche</name>
</author>
<author><name sortKey="Tampe, R" uniqKey="Tampe R">R. Tampe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alloatti, A" uniqKey="Alloatti A">A. Alloatti</name>
</author>
<author><name sortKey="Rookhuizen, D C" uniqKey="Rookhuizen D">D.C. Rookhuizen</name>
</author>
<author><name sortKey="Joannas, L" uniqKey="Joannas L">L. Joannas</name>
</author>
<author><name sortKey="Carpier, J M" uniqKey="Carpier J">J.M. Carpier</name>
</author>
<author><name sortKey="Iborra, S" uniqKey="Iborra S">S. Iborra</name>
</author>
<author><name sortKey="Magalhaes, J G" uniqKey="Magalhaes J">J.G. Magalhaes</name>
</author>
<author><name sortKey="Yatim, N" uniqKey="Yatim N">N. Yatim</name>
</author>
<author><name sortKey="Kozik, P" uniqKey="Kozik P">P. Kozik</name>
</author>
<author><name sortKey="Sancho, D" uniqKey="Sancho D">D. Sancho</name>
</author>
<author><name sortKey="Albert, M L" uniqKey="Albert M">M.L. Albert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, S J" uniqKey="Wu S">S.J. Wu</name>
</author>
<author><name sortKey="Niknafs, Y S" uniqKey="Niknafs Y">Y.S. Niknafs</name>
</author>
<author><name sortKey="Kim, S H" uniqKey="Kim S">S.H. Kim</name>
</author>
<author><name sortKey="Oravecz Wilson, K" uniqKey="Oravecz Wilson K">K. Oravecz-Wilson</name>
</author>
<author><name sortKey="Zajac, C" uniqKey="Zajac C">C. Zajac</name>
</author>
<author><name sortKey="Toubai, T" uniqKey="Toubai T">T. Toubai</name>
</author>
<author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name>
</author>
<author><name sortKey="Prasad, J" uniqKey="Prasad J">J. Prasad</name>
</author>
<author><name sortKey="Peltier, D" uniqKey="Peltier D">D. Peltier</name>
</author>
<author><name sortKey="Fujiwara, H" uniqKey="Fujiwara H">H. Fujiwara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Montealegre, S" uniqKey="Montealegre S">S. Montealegre</name>
</author>
<author><name sortKey="Van Endert, P" uniqKey="Van Endert P">P. van Endert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giodini, A" uniqKey="Giodini A">A. Giodini</name>
</author>
<author><name sortKey="Cresswell, P" uniqKey="Cresswell P">P. Cresswell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imai, J" uniqKey="Imai J">J. Imai</name>
</author>
<author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H. Hasegawa</name>
</author>
<author><name sortKey="Maruya, M" uniqKey="Maruya M">M. Maruya</name>
</author>
<author><name sortKey="Koyasu, S" uniqKey="Koyasu S">S. Koyasu</name>
</author>
<author><name sortKey="Yahara, I" uniqKey="Yahara I">I. Yahara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, R" uniqKey="Singh R">R. Singh</name>
</author>
<author><name sortKey="Cresswell, P" uniqKey="Cresswell P">P. Cresswell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hurst, K E" uniqKey="Hurst K">K.E. Hurst</name>
</author>
<author><name sortKey="Lawrence, K A" uniqKey="Lawrence K">K.A. Lawrence</name>
</author>
<author><name sortKey="Reyes Angeles, L" uniqKey="Reyes Angeles L">L. Reyes Angeles</name>
</author>
<author><name sortKey="Ye, Z" uniqKey="Ye Z">Z. Ye</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Townsend, D M" uniqKey="Townsend D">D.M. Townsend</name>
</author>
<author><name sortKey="Dolloff, N" uniqKey="Dolloff N">N. Dolloff</name>
</author>
<author><name sortKey="Thaxton, J E" uniqKey="Thaxton J">J.E. Thaxton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morito, D" uniqKey="Morito D">D. Morito</name>
</author>
<author><name sortKey="Nagata, K" uniqKey="Nagata K">K. Nagata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zehner, M" uniqKey="Zehner M">M. Zehner</name>
</author>
<author><name sortKey="Chasan, A I" uniqKey="Chasan A">A.I. Chasan</name>
</author>
<author><name sortKey="Schuette, V" uniqKey="Schuette V">V. Schuette</name>
</author>
<author><name sortKey="Embgenbroich, M" uniqKey="Embgenbroich M">M. Embgenbroich</name>
</author>
<author><name sortKey="Quast, T" uniqKey="Quast T">T. Quast</name>
</author>
<author><name sortKey="Kolanus, W" uniqKey="Kolanus W">W. Kolanus</name>
</author>
<author><name sortKey="Burgdorf, S" uniqKey="Burgdorf S">S. Burgdorf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sancho, D" uniqKey="Sancho D">D. Sancho</name>
</author>
<author><name sortKey="Mourao Sa, D" uniqKey="Mourao Sa D">D. Mourão-Sá</name>
</author>
<author><name sortKey="Joffre, O P" uniqKey="Joffre O">O.P. Joffre</name>
</author>
<author><name sortKey="Schulz, O" uniqKey="Schulz O">O. Schulz</name>
</author>
<author><name sortKey="Rogers, N C" uniqKey="Rogers N">N.C. Rogers</name>
</author>
<author><name sortKey="Pennington, D J" uniqKey="Pennington D">D.J. Pennington</name>
</author>
<author><name sortKey="Carlyle, J R" uniqKey="Carlyle J">J.R. Carlyle</name>
</author>
<author><name sortKey="Reis Sousa, C" uniqKey="Reis Sousa C">C. Reis Sousa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caminschi, I" uniqKey="Caminschi I">I. Caminschi</name>
</author>
<author><name sortKey="Proietto, A I" uniqKey="Proietto A">A.I. Proietto</name>
</author>
<author><name sortKey="Ahmet, F" uniqKey="Ahmet F">F. Ahmet</name>
</author>
<author><name sortKey="Kitsoulis, S" uniqKey="Kitsoulis S">S. Kitsoulis</name>
</author>
<author><name sortKey="Shin The, J" uniqKey="Shin The J">J. Shin The</name>
</author>
<author><name sortKey="Lo, J C" uniqKey="Lo J">J.C. Lo</name>
</author>
<author><name sortKey="Rizzitelli, A" uniqKey="Rizzitelli A">A. Rizzitelli</name>
</author>
<author><name sortKey="Wu, L" uniqKey="Wu L">L. Wu</name>
</author>
<author><name sortKey="Vremec, D" uniqKey="Vremec D">D. Vremec</name>
</author>
<author><name sortKey="Van Dommelen, S L" uniqKey="Van Dommelen S">S.L. van Dommelen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez Pomares, L" uniqKey="Martinez Pomares L">L. Martinez-Pomares</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hosokawa, N" uniqKey="Hosokawa N">N. Hosokawa</name>
</author>
<author><name sortKey="Kamiya, Y" uniqKey="Kamiya Y">Y. Kamiya</name>
</author>
<author><name sortKey="Kamiya, D" uniqKey="Kamiya D">D. Kamiya</name>
</author>
<author><name sortKey="Kato, K" uniqKey="Kato K">K. Kato</name>
</author>
<author><name sortKey="Nagata, K" uniqKey="Nagata K">K. Nagata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreer, C" uniqKey="Kreer C">C. Kreer</name>
</author>
<author><name sortKey="Kuepper, J M" uniqKey="Kuepper J">J.M. Kuepper</name>
</author>
<author><name sortKey="Zehner, M" uniqKey="Zehner M">M. Zehner</name>
</author>
<author><name sortKey="Quast, T" uniqKey="Quast T">T. Quast</name>
</author>
<author><name sortKey="Kolanus, W" uniqKey="Kolanus W">W. Kolanus</name>
</author>
<author><name sortKey="Schumak, B" uniqKey="Schumak B">B. Schumak</name>
</author>
<author><name sortKey="Burgdorf, S" uniqKey="Burgdorf S">S. Burgdorf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friedlander, R" uniqKey="Friedlander R">R. Friedlander</name>
</author>
<author><name sortKey="Jarosch, E" uniqKey="Jarosch E">E. Jarosch</name>
</author>
<author><name sortKey="Urban, J" uniqKey="Urban J">J. Urban</name>
</author>
<author><name sortKey="Volkwein, C" uniqKey="Volkwein C">C. Volkwein</name>
</author>
<author><name sortKey="Sommer, T" uniqKey="Sommer T">T. Sommer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Greenfield, J J" uniqKey="Greenfield J">J.J. Greenfield</name>
</author>
<author><name sortKey="High, S" uniqKey="High S">S. High</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalies, K U" uniqKey="Kalies K">K.U. Kalies</name>
</author>
<author><name sortKey="Rapoport, T A" uniqKey="Rapoport T">T.A. Rapoport</name>
</author>
<author><name sortKey="Hartmann, E" uniqKey="Hartmann E">E. Hartmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koopmann, J O" uniqKey="Koopmann J">J.O. Koopmann</name>
</author>
<author><name sortKey="Albring, J" uniqKey="Albring J">J. Albring</name>
</author>
<author><name sortKey="Huter, E" uniqKey="Huter E">E. Hüter</name>
</author>
<author><name sortKey="Bulbuc, N" uniqKey="Bulbuc N">N. Bulbuc</name>
</author>
<author><name sortKey="Spee, P" uniqKey="Spee P">P. Spee</name>
</author>
<author><name sortKey="Neefjes, J" uniqKey="Neefjes J">J. Neefjes</name>
</author>
<author><name sortKey="H Mmerling, G J" uniqKey="H Mmerling G">G.J. Hämmerling</name>
</author>
<author><name sortKey="Momburg, F" uniqKey="Momburg F">F. Momburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wirth, A" uniqKey="Wirth A">A. Wirth</name>
</author>
<author><name sortKey="Jung, M" uniqKey="Jung M">M. Jung</name>
</author>
<author><name sortKey="Bies, C" uniqKey="Bies C">C. Bies</name>
</author>
<author><name sortKey="Frien, M" uniqKey="Frien M">M. Frien</name>
</author>
<author><name sortKey="Tyedmers, J" uniqKey="Tyedmers J">J. Tyedmers</name>
</author>
<author><name sortKey="Zimmermann, R" uniqKey="Zimmermann R">R. Zimmermann</name>
</author>
<author><name sortKey="Wagner, R" uniqKey="Wagner R">R. Wagner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sch Uble, N" uniqKey="Sch Uble N">N. Schäuble</name>
</author>
<author><name sortKey="Cavalie, A" uniqKey="Cavalie A">A. Cavalié</name>
</author>
<author><name sortKey="Zimmermann, R" uniqKey="Zimmermann R">R. Zimmermann</name>
</author>
<author><name sortKey="Jung, M" uniqKey="Jung M">M. Jung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ackerman, A L" uniqKey="Ackerman A">A.L. Ackerman</name>
</author>
<author><name sortKey="Giodini, A" uniqKey="Giodini A">A. Giodini</name>
</author>
<author><name sortKey="Cresswell, P" uniqKey="Cresswell P">P. Cresswell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romisch, K" uniqKey="Romisch K">K. Romisch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="You, X" uniqKey="You X">X. You</name>
</author>
<author><name sortKey="Xu, D D" uniqKey="Xu D">D.D. Xu</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Gao, F G" uniqKey="Gao F">F.G. Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burgdorf, S" uniqKey="Burgdorf S">S. Burgdorf</name>
</author>
<author><name sortKey="Leister, P" uniqKey="Leister P">P. Leister</name>
</author>
<author><name sortKey="Scheidtmann, K H" uniqKey="Scheidtmann K">K.H. Scheidtmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imai, T" uniqKey="Imai T">T. Imai</name>
</author>
<author><name sortKey="Kato, Y" uniqKey="Kato Y">Y. Kato</name>
</author>
<author><name sortKey="Kajiwara, C" uniqKey="Kajiwara C">C. Kajiwara</name>
</author>
<author><name sortKey="Mizukami, S" uniqKey="Mizukami S">S. Mizukami</name>
</author>
<author><name sortKey="Ishige, I" uniqKey="Ishige I">I. Ishige</name>
</author>
<author><name sortKey="Ichiyanagi, T" uniqKey="Ichiyanagi T">T. Ichiyanagi</name>
</author>
<author><name sortKey="Hikida, M" uniqKey="Hikida M">M. Hikida</name>
</author>
<author><name sortKey="Wang, J Y" uniqKey="Wang J">J.Y. Wang</name>
</author>
<author><name sortKey="Udono, H" uniqKey="Udono H">H. Udono</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L. Li</name>
</author>
<author><name sortKey="Ye, Y" uniqKey="Ye Y">Y. Ye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reits, E" uniqKey="Reits E">E. Reits</name>
</author>
<author><name sortKey="Neijssen, J" uniqKey="Neijssen J">J. Neijssen</name>
</author>
<author><name sortKey="Herberts, C" uniqKey="Herberts C">C. Herberts</name>
</author>
<author><name sortKey="Benckhuijsen, W" uniqKey="Benckhuijsen W">W. Benckhuijsen</name>
</author>
<author><name sortKey="Janssen, L" uniqKey="Janssen L">L. Janssen</name>
</author>
<author><name sortKey="Drijfhout, J W" uniqKey="Drijfhout J">J.W. Drijfhout</name>
</author>
<author><name sortKey="Neefjes, J" uniqKey="Neefjes J">J. Neefjes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burgdorf, S" uniqKey="Burgdorf S">S. Burgdorf</name>
</author>
<author><name sortKey="Scholz, C" uniqKey="Scholz C">C. Schölz</name>
</author>
<author><name sortKey="Kautz, A" uniqKey="Kautz A">A. Kautz</name>
</author>
<author><name sortKey="Tampe, R" uniqKey="Tampe R">R. Tampé</name>
</author>
<author><name sortKey="Kurts, C" uniqKey="Kurts C">C. Kurts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saveanu, L" uniqKey="Saveanu L">L. Saveanu</name>
</author>
<author><name sortKey="Carroll, O" uniqKey="Carroll O">O. Carroll</name>
</author>
<author><name sortKey="Hassainya, Y" uniqKey="Hassainya Y">Y. Hassainya</name>
</author>
<author><name sortKey="Van Endert, P" uniqKey="Van Endert P">P. van Endert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saveanu, L" uniqKey="Saveanu L">L. Saveanu</name>
</author>
<author><name sortKey="Carroll, O" uniqKey="Carroll O">O. Carroll</name>
</author>
<author><name sortKey="Weimershaus, M" uniqKey="Weimershaus M">M. Weimershaus</name>
</author>
<author><name sortKey="Guermonprez, P" uniqKey="Guermonprez P">P. Guermonprez</name>
</author>
<author><name sortKey="Firat, E" uniqKey="Firat E">E. Firat</name>
</author>
<author><name sortKey="Lindo, V" uniqKey="Lindo V">V. Lindo</name>
</author>
<author><name sortKey="Greer, F" uniqKey="Greer F">F. Greer</name>
</author>
<author><name sortKey="Davoust, J" uniqKey="Davoust J">J. Davoust</name>
</author>
<author><name sortKey="Kratzer, R" uniqKey="Kratzer R">R. Kratzer</name>
</author>
<author><name sortKey="Keller, S R" uniqKey="Keller S">S.R. Keller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subtil, A" uniqKey="Subtil A">A. Subtil</name>
</author>
<author><name sortKey="Lampson, M A" uniqKey="Lampson M">M.A. Lampson</name>
</author>
<author><name sortKey="Keller, S R" uniqKey="Keller S">S.R. Keller</name>
</author>
<author><name sortKey="Mcgraw, T E" uniqKey="Mcgraw T">T.E. McGraw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Firat, E" uniqKey="Firat E">E. Firat</name>
</author>
<author><name sortKey="Saveanu, L" uniqKey="Saveanu L">L. Saveanu</name>
</author>
<author><name sortKey="Aichele, P" uniqKey="Aichele P">P. Aichele</name>
</author>
<author><name sortKey="Staeheli, P" uniqKey="Staeheli P">P. Staeheli</name>
</author>
<author><name sortKey="Huai, J" uniqKey="Huai J">J. Huai</name>
</author>
<author><name sortKey="Gaedicke, S" uniqKey="Gaedicke S">S. Gaedicke</name>
</author>
<author><name sortKey="Nil, A" uniqKey="Nil A">A. Nil</name>
</author>
<author><name sortKey="Besin, G" uniqKey="Besin G">G. Besin</name>
</author>
<author><name sortKey="Kanzler, B" uniqKey="Kanzler B">B. Kanzler</name>
</author>
<author><name sortKey="Van Endert, P" uniqKey="Van Endert P">P. van Endert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zagorac, G B" uniqKey="Zagorac G">G.B. Zagorac</name>
</author>
<author><name sortKey="Mahmutefendi, H" uniqKey="Mahmutefendi H">H. Mahmutefendić</name>
</author>
<author><name sortKey="Tomas, M I" uniqKey="Tomas M">M.I. Tomaš</name>
</author>
<author><name sortKey="Ku I, N" uniqKey="Ku I N">N. Kučić</name>
</author>
<author><name sortKey="Le Bouteiller, P" uniqKey="Le Bouteiller P">P. Le Bouteiller</name>
</author>
<author><name sortKey="Lu In, P" uniqKey="Lu In P">P. Lučin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, W" uniqKey="Ma W">W. Ma</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Vigneron, N" uniqKey="Vigneron N">N. Vigneron</name>
</author>
<author><name sortKey="Stroobant, V" uniqKey="Stroobant V">V. Stroobant</name>
</author>
<author><name sortKey="Thielemans, K" uniqKey="Thielemans K">K. Thielemans</name>
</author>
<author><name sortKey="Van Der Bruggen, P" uniqKey="Van Der Bruggen P">P. van der Bruggen</name>
</author>
<author><name sortKey="Van Den Eynde, B J" uniqKey="Van Den Eynde B">B.J. Van den Eynde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Osorio, F" uniqKey="Osorio F">F. Osorio</name>
</author>
<author><name sortKey="Tavernier, S J" uniqKey="Tavernier S">S.J. Tavernier</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E. Hoffmann</name>
</author>
<author><name sortKey="Saeys, Y" uniqKey="Saeys Y">Y. Saeys</name>
</author>
<author><name sortKey="Martens, L" uniqKey="Martens L">L. Martens</name>
</author>
<author><name sortKey="Vetters, J" uniqKey="Vetters J">J. Vetters</name>
</author>
<author><name sortKey="Delrue, I" uniqKey="Delrue I">I. Delrue</name>
</author>
<author><name sortKey="De Rycke, R" uniqKey="De Rycke R">R. De Rycke</name>
</author>
<author><name sortKey="Parthoens, E" uniqKey="Parthoens E">E. Parthoens</name>
</author>
<author><name sortKey="Pouliot, P" uniqKey="Pouliot P">P. Pouliot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cubillos Ruiz, J R" uniqKey="Cubillos Ruiz J">J.R. Cubillos-Ruiz</name>
</author>
<author><name sortKey="Silberman, P C" uniqKey="Silberman P">P.C. Silberman</name>
</author>
<author><name sortKey="Rutkowski, M R" uniqKey="Rutkowski M">M.R. Rutkowski</name>
</author>
<author><name sortKey="Chopra, S" uniqKey="Chopra S">S. Chopra</name>
</author>
<author><name sortKey="Perales Puchalt, A" uniqKey="Perales Puchalt A">A. Perales-Puchalt</name>
</author>
<author><name sortKey="Song, M" uniqKey="Song M">M. Song</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name>
</author>
<author><name sortKey="Bettigole, S E" uniqKey="Bettigole S">S.E. Bettigole</name>
</author>
<author><name sortKey="Gupta, D" uniqKey="Gupta D">D. Gupta</name>
</author>
<author><name sortKey="Holcomb, K" uniqKey="Holcomb K">K. Holcomb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y. Imai</name>
</author>
<author><name sortKey="Kuba, K" uniqKey="Kuba K">K. Kuba</name>
</author>
<author><name sortKey="Neely, G G" uniqKey="Neely G">G.G. Neely</name>
</author>
<author><name sortKey="Yaghubian Malhami, R" uniqKey="Yaghubian Malhami R">R. Yaghubian-Malhami</name>
</author>
<author><name sortKey="Perkmann, T" uniqKey="Perkmann T">T. Perkmann</name>
</author>
<author><name sortKey="Van Loo, G" uniqKey="Van Loo G">G. van Loo</name>
</author>
<author><name sortKey="Ermolaeva, M" uniqKey="Ermolaeva M">M. Ermolaeva</name>
</author>
<author><name sortKey="Veldhuizen, R" uniqKey="Veldhuizen R">R. Veldhuizen</name>
</author>
<author><name sortKey="Leung, Y H" uniqKey="Leung Y">Y.H. Leung</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mutoh, A" uniqKey="Mutoh A">A. Mutoh</name>
</author>
<author><name sortKey="Ueda, S" uniqKey="Ueda S">S. Ueda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Retamal Diaz, A" uniqKey="Retamal Diaz A">A. Retamal-Diaz</name>
</author>
<author><name sortKey="Weiss, K A" uniqKey="Weiss K">K.A. Weiss</name>
</author>
<author><name sortKey="Tognarelli, E I" uniqKey="Tognarelli E">E.I. Tognarelli</name>
</author>
<author><name sortKey="Freire, M" uniqKey="Freire M">M. Freire</name>
</author>
<author><name sortKey="Bueno, S M" uniqKey="Bueno S">S.M. Bueno</name>
</author>
<author><name sortKey="Herold, B C" uniqKey="Herold B">B.C. Herold</name>
</author>
<author><name sortKey="Jacobs, W R" uniqKey="Jacobs W">W.R. Jacobs</name>
</author>
<author><name sortKey="Gonzalez, P A" uniqKey="Gonzalez P">P.A. Gonzalez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodvold, J J" uniqKey="Rodvold J">J.J. Rodvold</name>
</author>
<author><name sortKey="Mahadevan, N R" uniqKey="Mahadevan N">N.R. Mahadevan</name>
</author>
<author><name sortKey="Zanetti, M" uniqKey="Zanetti M">M. Zanetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reading, J L" uniqKey="Reading J">J.L. Reading</name>
</author>
<author><name sortKey="Galvez Cancino, F" uniqKey="Galvez Cancino F">F. Gálvez-Cancino</name>
</author>
<author><name sortKey="Swanton, C" uniqKey="Swanton C">C. Swanton</name>
</author>
<author><name sortKey="Lladser, A" uniqKey="Lladser A">A. Lladser</name>
</author>
<author><name sortKey="Peggs, K S" uniqKey="Peggs K">K.S. Peggs</name>
</author>
<author><name sortKey="Quezada, S A" uniqKey="Quezada S">S.A. Quezada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gebhardt, T" uniqKey="Gebhardt T">T. Gebhardt</name>
</author>
<author><name sortKey="Palendira, U" uniqKey="Palendira U">U. Palendira</name>
</author>
<author><name sortKey="Tscharke, D C" uniqKey="Tscharke D">D.C. Tscharke</name>
</author>
<author><name sortKey="Bedoui, S" uniqKey="Bedoui S">S. Bedoui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name>
</author>
<author><name sortKey="Uematsu, S" uniqKey="Uematsu S">S. Uematsu</name>
</author>
<author><name sortKey="Takeuchi, O" uniqKey="Takeuchi O">O. Takeuchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R. Medzhitov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reverendo, M" uniqKey="Reverendo M">M. Reverendo</name>
</author>
<author><name sortKey="Mendes, A" uniqKey="Mendes A">A. Mendes</name>
</author>
<author><name sortKey="Arguello, R J" uniqKey="Arguello R">R.J. Arguello</name>
</author>
<author><name sortKey="Gatti, E" uniqKey="Gatti E">E. Gatti</name>
</author>
<author><name sortKey="Pierre, P" uniqKey="Pierre P">P. Pierre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pizzurro, G A" uniqKey="Pizzurro G">G.A. Pizzurro</name>
</author>
<author><name sortKey="Tapia, I J" uniqKey="Tapia I">I.J. Tapia</name>
</author>
<author><name sortKey="Sganga, L" uniqKey="Sganga L">L. Sganga</name>
</author>
<author><name sortKey="Podhajcer, O L" uniqKey="Podhajcer O">O.L. Podhajcer</name>
</author>
<author><name sortKey="Mordoh, J" uniqKey="Mordoh J">J. Mordoh</name>
</author>
<author><name sortKey="Barrio, M M" uniqKey="Barrio M">M.M. Barrio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alloatti, A" uniqKey="Alloatti A">A. Alloatti</name>
</author>
<author><name sortKey="Kotsias, F" uniqKey="Kotsias F">F. Kotsias</name>
</author>
<author><name sortKey="Magalhaes, J G" uniqKey="Magalhaes J">J.G. Magalhaes</name>
</author>
<author><name sortKey="Amigorena, S" uniqKey="Amigorena S">S. Amigorena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chi, H" uniqKey="Chi H">H. Chi</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C. Li</name>
</author>
<author><name sortKey="Zhao, F S" uniqKey="Zhao F">F.S. Zhao</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name>
</author>
<author><name sortKey="Ng, T B" uniqKey="Ng T">T.B. Ng</name>
</author>
<author><name sortKey="Jin, G" uniqKey="Jin G">G. Jin</name>
</author>
<author><name sortKey="Sha, O" uniqKey="Sha O">O. Sha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vacchelli, E" uniqKey="Vacchelli E">E. Vacchelli</name>
</author>
<author><name sortKey="Eggermont, A" uniqKey="Eggermont A">A. Eggermont</name>
</author>
<author><name sortKey="Sautes Fridman, C" uniqKey="Sautes Fridman C">C. Sautès-Fridman</name>
</author>
<author><name sortKey="Galon, J" uniqKey="Galon J">J. Galon</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
<author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bourque, J" uniqKey="Bourque J">J. Bourque</name>
</author>
<author><name sortKey="Hawiger, D" uniqKey="Hawiger D">D. Hawiger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weimershaus, M" uniqKey="Weimershaus M">M. Weimershaus</name>
</author>
<author><name sortKey="Mauvais, F X" uniqKey="Mauvais F">F.X. Mauvais</name>
</author>
<author><name sortKey="Saveanu, L" uniqKey="Saveanu L">L. Saveanu</name>
</author>
<author><name sortKey="Adiko, C" uniqKey="Adiko C">C. Adiko</name>
</author>
<author><name sortKey="Babdor, J" uniqKey="Babdor J">J. Babdor</name>
</author>
<author><name sortKey="Abramova, A" uniqKey="Abramova A">A. Abramova</name>
</author>
<author><name sortKey="Montealegre, S" uniqKey="Montealegre S">S. Montealegre</name>
</author>
<author><name sortKey="Lawand, M" uniqKey="Lawand M">M. Lawand</name>
</author>
<author><name sortKey="Evnouchidou, I" uniqKey="Evnouchidou I">I. Evnouchidou</name>
</author>
<author><name sortKey="Huber, K J" uniqKey="Huber K">K.J. Huber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pauwels, A M" uniqKey="Pauwels A">A.M. Pauwels</name>
</author>
<author><name sortKey="Hartlova, A" uniqKey="Hartlova A">A. Hartlova</name>
</author>
<author><name sortKey="Peltier, J" uniqKey="Peltier J">J. Peltier</name>
</author>
<author><name sortKey="Driege, Y" uniqKey="Driege Y">Y. Driege</name>
</author>
<author><name sortKey="Baudelet, G" uniqKey="Baudelet G">G. Baudelet</name>
</author>
<author><name sortKey="Brodin, P" uniqKey="Brodin P">P. Brodin</name>
</author>
<author><name sortKey="Trost, M" uniqKey="Trost M">M. Trost</name>
</author>
<author><name sortKey="Beyaert, R" uniqKey="Beyaert R">R. Beyaert</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E. Hoffmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blander, J M" uniqKey="Blander J">J.M. Blander</name>
</author>
<author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R. Medzhitov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corridoni, D" uniqKey="Corridoni D">D. Corridoni</name>
</author>
<author><name sortKey="Shiraishi, S" uniqKey="Shiraishi S">S. Shiraishi</name>
</author>
<author><name sortKey="Chapman, T" uniqKey="Chapman T">T. Chapman</name>
</author>
<author><name sortKey="Steevels, T" uniqKey="Steevels T">T. Steevels</name>
</author>
<author><name sortKey="Muraro, D" uniqKey="Muraro D">D. Muraro</name>
</author>
<author><name sortKey="Thezenas, M L" uniqKey="Thezenas M">M.L. Thezenas</name>
</author>
<author><name sortKey="Prota, G" uniqKey="Prota G">G. Prota</name>
</author>
<author><name sortKey="Chen, J L" uniqKey="Chen J">J.L. Chen</name>
</author>
<author><name sortKey="Gileadi, U" uniqKey="Gileadi U">U. Gileadi</name>
</author>
<author><name sortKey="Ternette, N" uniqKey="Ternette N">N. Ternette</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jelinek, I" uniqKey="Jelinek I">I. Jelinek</name>
</author>
<author><name sortKey="Leonard, J N" uniqKey="Leonard J">J.N. Leonard</name>
</author>
<author><name sortKey="Price, G E" uniqKey="Price G">G.E. Price</name>
</author>
<author><name sortKey="Brown, K N" uniqKey="Brown K">K.N. Brown</name>
</author>
<author><name sortKey="Meyer Manlapat, A" uniqKey="Meyer Manlapat A">A. Meyer-Manlapat</name>
</author>
<author><name sortKey="Goldsmith, P K" uniqKey="Goldsmith P">P.K. Goldsmith</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Venzon, D" uniqKey="Venzon D">D. Venzon</name>
</author>
<author><name sortKey="Epstein, S L" uniqKey="Epstein S">S.L. Epstein</name>
</author>
<author><name sortKey="Segal, D M" uniqKey="Segal D">D.M. Segal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Asano, J" uniqKey="Asano J">J. Asano</name>
</author>
<author><name sortKey="Tada, H" uniqKey="Tada H">H. Tada</name>
</author>
<author><name sortKey="Onai, N" uniqKey="Onai N">N. Onai</name>
</author>
<author><name sortKey="Sato, T" uniqKey="Sato T">T. Sato</name>
</author>
<author><name sortKey="Horie, Y" uniqKey="Horie Y">Y. Horie</name>
</author>
<author><name sortKey="Fujimoto, Y" uniqKey="Fujimoto Y">Y. Fujimoto</name>
</author>
<author><name sortKey="Fukase, K" uniqKey="Fukase K">K. Fukase</name>
</author>
<author><name sortKey="Suzuki, A" uniqKey="Suzuki A">A. Suzuki</name>
</author>
<author><name sortKey="Mak, T W" uniqKey="Mak T">T.W. Mak</name>
</author>
<author><name sortKey="Ohteki, T" uniqKey="Ohteki T">T. Ohteki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Visvikis, O" uniqKey="Visvikis O">O. Visvikis</name>
</author>
<author><name sortKey="Ihuegbu, N" uniqKey="Ihuegbu N">N. Ihuegbu</name>
</author>
<author><name sortKey="Labed, S A" uniqKey="Labed S">S.A. Labed</name>
</author>
<author><name sortKey="Luhachack, L G" uniqKey="Luhachack L">L.G. Luhachack</name>
</author>
<author><name sortKey="Alves, A F" uniqKey="Alves A">A.F. Alves</name>
</author>
<author><name sortKey="Wollenberg, A C" uniqKey="Wollenberg A">A.C. Wollenberg</name>
</author>
<author><name sortKey="Stuart, L M" uniqKey="Stuart L">L.M. Stuart</name>
</author>
<author><name sortKey="Stormo, G D" uniqKey="Stormo G">G.D. Stormo</name>
</author>
<author><name sortKey="Irazoqui, J E" uniqKey="Irazoqui J">J.E. Irazoqui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name>
</author>
<author><name sortKey="Wei, K" uniqKey="Wei K">K. Wei</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name>
</author>
<author><name sortKey="Tang, K" uniqKey="Tang K">K. Tang</name>
</author>
<author><name sortKey="Li, F" uniqKey="Li F">F. Li</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T. Zhang</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
<author><name sortKey="Xu, P" uniqKey="Xu P">P. Xu</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y. Yu</name>
</author>
<author><name sortKey="Sun, W" uniqKey="Sun W">W. Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Faure Andre, G" uniqKey="Faure Andre G">G. Faure-André</name>
</author>
<author><name sortKey="Vargas, P" uniqKey="Vargas P">P. Vargas</name>
</author>
<author><name sortKey="Yuseff, M" uniqKey="Yuseff M">M. Yuseff</name>
</author>
<author><name sortKey="Heuze, M" uniqKey="Heuze M">M. Heuzé</name>
</author>
<author><name sortKey="Diaz, J" uniqKey="Diaz J">J. Diaz</name>
</author>
<author><name sortKey="Lankar, D" uniqKey="Lankar D">D. Lankar</name>
</author>
<author><name sortKey="Steri, V" uniqKey="Steri V">V. Steri</name>
</author>
<author><name sortKey="Manry, J" uniqKey="Manry J">J. Manry</name>
</author>
<author><name sortKey="Hugues, S" uniqKey="Hugues S">S. Hugues</name>
</author>
<author><name sortKey="Vascotto, F" uniqKey="Vascotto F">F. Vascotto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vargas, P" uniqKey="Vargas P">P. Vargas</name>
</author>
<author><name sortKey="Maiuri, P" uniqKey="Maiuri P">P. Maiuri</name>
</author>
<author><name sortKey="Bretou, M" uniqKey="Bretou M">M. Bretou</name>
</author>
<author><name sortKey="Saez, P J" uniqKey="Saez P">P.J. Sáez</name>
</author>
<author><name sortKey="Pierobon, P" uniqKey="Pierobon P">P. Pierobon</name>
</author>
<author><name sortKey="Maurin, M" uniqKey="Maurin M">M. Maurin</name>
</author>
<author><name sortKey="Chabaud, M" uniqKey="Chabaud M">M. Chabaud</name>
</author>
<author><name sortKey="Lankar, D" uniqKey="Lankar D">D. Lankar</name>
</author>
<author><name sortKey="Obino, D" uniqKey="Obino D">D. Obino</name>
</author>
<author><name sortKey="Terriac, E" uniqKey="Terriac E">E. Terriac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dalod, M" uniqKey="Dalod M">M. Dalod</name>
</author>
<author><name sortKey="Chelbi, R" uniqKey="Chelbi R">R. Chelbi</name>
</author>
<author><name sortKey="Malissen, B" uniqKey="Malissen B">B. Malissen</name>
</author>
<author><name sortKey="Lawrence, T" uniqKey="Lawrence T">T. Lawrence</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name>
</author>
<author><name sortKey="Senovilla, L" uniqKey="Senovilla L">L. Senovilla</name>
</author>
<author><name sortKey="Vacchelli, E" uniqKey="Vacchelli E">E. Vacchelli</name>
</author>
<author><name sortKey="Eggermont, A" uniqKey="Eggermont A">A. Eggermont</name>
</author>
<author><name sortKey="Fridman, W H" uniqKey="Fridman W">W.H. Fridman</name>
</author>
<author><name sortKey="Galon, J" uniqKey="Galon J">J. Galon</name>
</author>
<author><name sortKey="Sautes Fridman, C" uniqKey="Sautes Fridman C">C. Sautès-Fridman</name>
</author>
<author><name sortKey="Tartour, E" uniqKey="Tartour E">E. Tartour</name>
</author>
<author><name sortKey="Zitvogel, L" uniqKey="Zitvogel L">L. Zitvogel</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Pharmaceutics</journal-id>
<journal-id journal-id-type="iso-abbrev">Pharmaceutics</journal-id>
<journal-id journal-id-type="publisher-id">pharmaceutics</journal-id>
<journal-title-group><journal-title>Pharmaceutics</journal-title>
</journal-title-group>
<issn pub-type="epub">1999-4923</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32070016</article-id>
<article-id pub-id-type="pmc">7076524</article-id>
<article-id pub-id-type="doi">10.3390/pharmaceutics12020153</article-id>
<article-id pub-id-type="publisher-id">pharmaceutics-12-00153</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Endoplasmic Reticulum-Associated Degradation-Dependent Processing in Cross-Presentation and Its Potential for Dendritic Cell Vaccinations: A Review</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Imai</surname>
<given-names>Jun</given-names>
</name>
<xref rid="c1-pharmaceutics-12-00153" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ohashi</surname>
<given-names>Sayaka</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sakai</surname>
<given-names>Takahiro</given-names>
</name>
</contrib>
</contrib-group>
<aff id="af1-pharmaceutics-12-00153">Laboratory of Physiological Chemistry, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma 370-0033, Japan;<email>0621021@takasaki-u.ac.jp</email>
(S.O.);<email>sakai@takasaki-u.ac.jp</email>
(T.S.)</aff>
<author-notes><corresp id="c1-pharmaceutics-12-00153"><label>*</label>
Correspondence: <email>jimai@takasaki-u.ac.jp</email>
; Tel.: +81-27-352-1180</corresp>
</author-notes>
<pub-date pub-type="epub"><day>13</day>
<month>2</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><month>2</month>
<year>2020</year>
</pub-date>
<volume>12</volume>
<issue>2</issue>
<elocation-id>153</elocation-id>
<history><date date-type="received"><day>15</day>
<month>1</month>
<year>2020</year>
</date>
<date date-type="accepted"><day>12</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© 2020 by the authors.</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>While the success of dendritic cell (DC) vaccination largely depends on cross-presentation (CP) efficiency, the precise molecular mechanism of CP is not yet characterized. Recent research revealed that endoplasmic reticulum (ER)-associated degradation (ERAD), which was first identified as part of the protein quality control system in the ER, plays a pivotal role in the processing of extracellular proteins in CP. The discovery of ERAD-dependent processing strongly suggests that the properties of extracellular antigens are one of the keys to effective DC vaccination, in addition to DC subsets and the maturation of these cells. In this review, we address recent advances in CP, focusing on the molecular mechanisms of the ERAD-dependent processing of extracellular proteins. As ERAD itself and the ERAD-dependent processing in CP share cellular machinery, enhancing the recognition of extracellular proteins, such as the ERAD substrate, by ex vivo methods may serve to improve the efficacy of DC vaccination.</p>
</abstract>
<kwd-group><kwd>dendritic cell</kwd>
<kwd>cross-presentation</kwd>
<kwd>major histocompatibility class I</kwd>
<kwd>endoplasmic reticulum-associated degradation</kwd>
<kwd>molecular chaperone</kwd>
<kwd>DC vaccination</kwd>
</kwd-group>
</article-meta>
</front>
<body><sec sec-type="intro" id="sec1-pharmaceutics-12-00153"><title>1. Introduction</title>
<p>Cancer vaccination is the most well-studied immunotherapeutic strategy among cancer immunotherapies [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. Like virus vaccines and toxoid vaccines, cancer vaccines immunize patients with proteins from cancer cells with the hope of activating the immune system to destroy the cancer cells. Cancer vaccines are intended to activate the response of cancer-specific cytotoxic T lymphocytes (CTLs), resulting in the rejection of cancer cells by long-lasting anti-cancer immunity. While anti-virus vaccines, such as the human papilloma virus (HPV) vaccine and the hepatitis B virus (HBV) vaccine, successfully prevent specific cancers caused by viruses [<xref rid="B2-pharmaceutics-12-00153" ref-type="bibr">2</xref>
], most cancer vaccines have failed or had a limited effect in clinical trials [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. This limited effect is partially due to malignant cancer cells exhibiting weak immunogenicity, allowing for efficient immune escape [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. Additionally, although cancer vaccines can activate cancer-specific CTLs, malignant cancer cells are equipped with several methods to evade the immune system [<xref rid="B3-pharmaceutics-12-00153" ref-type="bibr">3</xref>
].</p>
<p>To stimulate the cancer-specific immune response more effectively, dendritic cell (DC) vaccines were developed with high expectations, since DCs exhibit a strong ability to activate a cytotoxic response toward specific antigens [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. DCs are isolated from the patient for immunotherapy, immunized with a cancer antigen or cancer lysate, and transfused back to the patient [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. DCs internalize immunized proteins and present processed antigenic peptides to the major histocompatibility complex (MHC) class I (MHC I) and MHC class II (MHC II) molecules, which are presented via MHC II in other antigen-presenting cells (APCs) [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. These specific activities of DCs are referred to as cross-presentation (CP), and play a definitive role in initiating CD8<sup>+</sup>
T cell-induced immune responses against cancer and/or viruses (cross-priming) or to induce peripheral tolerance (cross-tolerance) [<xref rid="B4-pharmaceutics-12-00153" ref-type="bibr">4</xref>
,<xref rid="B5-pharmaceutics-12-00153" ref-type="bibr">5</xref>
,<xref rid="B6-pharmaceutics-12-00153" ref-type="bibr">6</xref>
,<xref rid="B7-pharmaceutics-12-00153" ref-type="bibr">7</xref>
,<xref rid="B8-pharmaceutics-12-00153" ref-type="bibr">8</xref>
]. Since effective activation of cancer-specific CTLs results in the successful inhibition of malignant cancer progression [<xref rid="B9-pharmaceutics-12-00153" ref-type="bibr">9</xref>
,<xref rid="B10-pharmaceutics-12-00153" ref-type="bibr">10</xref>
], the effective CP of cancer-associated antigens is one of the essential requirements for an effective immune response in cancer immunotherapy [<xref rid="B11-pharmaceutics-12-00153" ref-type="bibr">11</xref>
,<xref rid="B12-pharmaceutics-12-00153" ref-type="bibr">12</xref>
,<xref rid="B13-pharmaceutics-12-00153" ref-type="bibr">13</xref>
]. However, in the absence of CP, the immune system theoretically produces predominantly T helper 2 (Th2) responses rather than T helper 1 (Th1) responses associated with antigen-specific CTLs, resulting in no tolerance to cancer. However, the results of DC vaccination have been disappointing, and limited CP activity may have resulted in insufficient numbers of CTLs [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
].</p>
<p>In the last couple of decades, numerous efforts have been made to elucidate the molecular mechanism of CP, which revealed that immunized proteins are processed by the endoplasmic reticulum-associated degradation (ERAD) pathway [<xref rid="B14-pharmaceutics-12-00153" ref-type="bibr">14</xref>
]. ERAD was first described as a part of the cellular pathway for protein quality control in the ER: The unfolded protein response (UPR) [<xref rid="B15-pharmaceutics-12-00153" ref-type="bibr">15</xref>
]. Though the substrates of ERAD are unfolded proteins in the ER, these proteins are not degraded in the ER lumen, but rather retro-transported out of the ER lumen into the cytosol and degraded by the ubiquitin-proteasome system (UPS) [<xref rid="B16-pharmaceutics-12-00153" ref-type="bibr">16</xref>
]. While one of the aims of these investigations was the improvement of CP efficiency, which was partially accomplished in a mouse model [<xref rid="B17-pharmaceutics-12-00153" ref-type="bibr">17</xref>
,<xref rid="B18-pharmaceutics-12-00153" ref-type="bibr">18</xref>
,<xref rid="B19-pharmaceutics-12-00153" ref-type="bibr">19</xref>
], this has not contributed to the improvement of DC vaccination in clinical trials [<xref rid="B20-pharmaceutics-12-00153" ref-type="bibr">20</xref>
].</p>
<p>In contrast to investigations on the molecular mechanism of CP, deciphering the immune escape mechanism of malignant cancers has led to the establishment of new immunotherapeutic methods: Namely, immune checkpoint inhibition therapies [<xref rid="B21-pharmaceutics-12-00153" ref-type="bibr">21</xref>
,<xref rid="B22-pharmaceutics-12-00153" ref-type="bibr">22</xref>
,<xref rid="B23-pharmaceutics-12-00153" ref-type="bibr">23</xref>
,<xref rid="B24-pharmaceutics-12-00153" ref-type="bibr">24</xref>
]. However, CP by DCs is essential for the successful outcome of these methods [<xref rid="B25-pharmaceutics-12-00153" ref-type="bibr">25</xref>
]. In that sense, the DC vaccine appears to be an attractive cancer immunotherapy approach in combination with immune checkpoint inhibition therapy [<xref rid="B26-pharmaceutics-12-00153" ref-type="bibr">26</xref>
]. Additionally, recent research revealed that even in cancer chemotherapy or cancer radiation therapy, CP by DCs is essential in eliminating cancers [<xref rid="B27-pharmaceutics-12-00153" ref-type="bibr">27</xref>
,<xref rid="B28-pharmaceutics-12-00153" ref-type="bibr">28</xref>
]. However, insufficient CP efficiency persists through the rate-determining steps, not only in DC vaccination, but also for other cancer therapies. Therefore, CP efficiency has been described as the rate-determining step for these therapies, since poor CP efficiency results in the poor activation of cancer-specific CTLs. Several rate-limiting steps have been shown to critically contribute to CP efficiency: <list list-type="simple"><list-item><label>(i)</label>
<p>Restricted lysosomal degradation of extracellular proteins</p>
</list-item>
<list-item><label>(ii)</label>
<p>Recruitment of ERAD-related molecules into endocytotic compartments</p>
</list-item>
<list-item><label>(iii)</label>
<p>Retro-transport of extracellular proteins into the cytosol</p>
</list-item>
</list>
</p>
<p>In this article, we discuss the current concepts of CP, focusing on the improvements of CP efficiency, and more specifically, on the cellular transport route employed by immunized proteins and the molecular mechanism of their recognition as the ERAD substrate.</p>
</sec>
<sec id="sec2-pharmaceutics-12-00153"><title>2. Dendritic Cell (DC) Vaccination</title>
<sec id="sec2dot1-pharmaceutics-12-00153"><title>2.1. DC Subsets</title>
<p>DCs are a diverse group of specialized APCs with key roles in the initiation and regulation of antigen-specific immunity and tolerance [<xref rid="B29-pharmaceutics-12-00153" ref-type="bibr">29</xref>
]. In the peripheral tissue, DCs incorporate extracellular antigens and sense their environments by cytokine receptors or pattern recognition receptors (PRRs), which specifically detect pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) [<xref rid="B30-pharmaceutics-12-00153" ref-type="bibr">30</xref>
]. After detecting immunological stimulants and processing antigens, DCs undergo maturation and migrate into the draining lymph nodes where they demonstrate substantial morphological alternations, and initiate immune responses by presenting antigens to T cells and by providing immuno-modulatory molecules and cytokines according to the situation [<xref rid="B31-pharmaceutics-12-00153" ref-type="bibr">31</xref>
,<xref rid="B32-pharmaceutics-12-00153" ref-type="bibr">32</xref>
]. </p>
<p>Both mouse and human DCs are divided into four main populations: conventional DCs (cDCs) [<xref rid="B33-pharmaceutics-12-00153" ref-type="bibr">33</xref>
], plasmacytoid DCs (pDCs) [<xref rid="B34-pharmaceutics-12-00153" ref-type="bibr">34</xref>
], monocyte-derived DCs (moDCs) [<xref rid="B35-pharmaceutics-12-00153" ref-type="bibr">35</xref>
,<xref rid="B36-pharmaceutics-12-00153" ref-type="bibr">36</xref>
], and Langerhans cells (LCs), all of which differ in ontology, phenotype, and functions. cDCs are further divided into two subpopulations called Th1-activating cDCs (cDC1s) and Th2-activating cDCs (cDC2s) in mice [<xref rid="B31-pharmaceutics-12-00153" ref-type="bibr">31</xref>
]. Closely related counterparts are found in humans; however, surface molecules and cytokine profiles do not precisely correspond to each other [<xref rid="B37-pharmaceutics-12-00153" ref-type="bibr">37</xref>
] (<xref rid="pharmaceutics-12-00153-t001" ref-type="table">Table 1</xref>
). cDC1s play indispensable roles in cancer immune therapy and have demonstrated the most substantial CP efficiency, irrespective of the protein uptake route [<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
]. In addition to their ability to activate CD8<sup>+</sup>
T cells via CP, cDC1s also initiate CD4<sup>+</sup>
helper T-cells for full activation of CTLs [<xref rid="B39-pharmaceutics-12-00153" ref-type="bibr">39</xref>
,<xref rid="B40-pharmaceutics-12-00153" ref-type="bibr">40</xref>
] and expansion of memory T cells [<xref rid="B41-pharmaceutics-12-00153" ref-type="bibr">41</xref>
]. Additionally, human (to a lesser degree) and mouse cDC1s produce IL-12, which is critical for the differentiation of naïve T cells into Th1 cells [<xref rid="B42-pharmaceutics-12-00153" ref-type="bibr">42</xref>
,<xref rid="B43-pharmaceutics-12-00153" ref-type="bibr">43</xref>
]. Indeed, expression of CP-related molecules was found to be higher in splenic cDC1s than in splenic cDC2s [<xref rid="B44-pharmaceutics-12-00153" ref-type="bibr">44</xref>
]. Cancer graft experiments in mice revealed that immune checkpoint inhibition therapies showed no effects without cDC1s [<xref rid="B11-pharmaceutics-12-00153" ref-type="bibr">11</xref>
,<xref rid="B45-pharmaceutics-12-00153" ref-type="bibr">45</xref>
]. Likewise, in humans, the migration of cDC1s in the cancer microenvironment is essential for immune checkpoint inhibition therapy [<xref rid="B46-pharmaceutics-12-00153" ref-type="bibr">46</xref>
]. These results indicate that cDC1s are the best-suited subset for DC vaccination; however, collecting an adequate number of human cDC1s remains challenging, resulting in too few for administration in a DC vaccination platform. While cDC2s are a potent inducer of Th2 and T helper 17 (Th17) responses, showing restricted CP ability in mice [<xref rid="B35-pharmaceutics-12-00153" ref-type="bibr">35</xref>
,<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
], human cDC2s can induce the polarization of diverse subsets of CD4<sup>+</sup>
T cells and activate CD8<sup>+</sup>
T cells to induce Th1 responses [<xref rid="B47-pharmaceutics-12-00153" ref-type="bibr">47</xref>
,<xref rid="B48-pharmaceutics-12-00153" ref-type="bibr">48</xref>
,<xref rid="B49-pharmaceutics-12-00153" ref-type="bibr">49</xref>
,<xref rid="B50-pharmaceutics-12-00153" ref-type="bibr">50</xref>
]. The CP efficiency of cDC2s was equivalent to that of cDC1s for receptor-mediated endocytosis, but was less efficient for pinocytosis and phagocytosis in mice [<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
]. Thus, cDC2s may be of use in DC vaccination; however, they are principally not recommended.</p>
<p>While pDCs produce large amounts of type I interferon and play central roles in the immune defense against viral infections [<xref rid="B51-pharmaceutics-12-00153" ref-type="bibr">51</xref>
], these cells show generally poor CP ability [<xref rid="B52-pharmaceutics-12-00153" ref-type="bibr">52</xref>
]. In both humans and mice, only myeloid-derived pDCs can activate CD8<sup>+</sup>
T cells, yet they exhibit relatively poor priming capacity for naïve T cells [<xref rid="B47-pharmaceutics-12-00153" ref-type="bibr">47</xref>
,<xref rid="B48-pharmaceutics-12-00153" ref-type="bibr">48</xref>
]. Therefore, pDCs cannot play a decisive role in DC vaccination.</p>
<p>The moDCs, which express CD11c and MHC II [<xref rid="B53-pharmaceutics-12-00153" ref-type="bibr">53</xref>
], differentiate from monocytes, predominantly under inflammatory conditions. Thus, they are also called inflammatory DCs [<xref rid="B54-pharmaceutics-12-00153" ref-type="bibr">54</xref>
,<xref rid="B55-pharmaceutics-12-00153" ref-type="bibr">55</xref>
,<xref rid="B56-pharmaceutics-12-00153" ref-type="bibr">56</xref>
]. Bone marrow-derived DCs (BMDCs) show similar characteristics to moDCs, which differentiate from myeloid cells under the presence of granular colony-stimulating factor (GM-CSF). Both moDCs [<xref rid="B57-pharmaceutics-12-00153" ref-type="bibr">57</xref>
,<xref rid="B58-pharmaceutics-12-00153" ref-type="bibr">58</xref>
] and BMDCs [<xref rid="B59-pharmaceutics-12-00153" ref-type="bibr">59</xref>
,<xref rid="B60-pharmaceutics-12-00153" ref-type="bibr">60</xref>
] show efficient CP capacity to activate naïve CD8<sup>+</sup>
T cells, similar to cDC1s. Further, in mice, they efficiently activate naïve CD8<sup>+</sup>
T cells for pinocytosis [<xref rid="B61-pharmaceutics-12-00153" ref-type="bibr">61</xref>
], less efficiently for receptor-mediated endocytosis, and not at all for phagocytosis [<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
]. Additionally, these cells can differentiate CD4<sup>+</sup>
T cells toward Th2 cells and Th17 cells in addition to Th1 cells in humans [<xref rid="B49-pharmaceutics-12-00153" ref-type="bibr">49</xref>
]. While moDCs and cDC2s are clearly distinguishable in mice, they express notably similar cell surface markers in humans. Currently, the precise ontology and specific roles played by these cells have not yet been elucidated in humans [<xref rid="B31-pharmaceutics-12-00153" ref-type="bibr">31</xref>
,<xref rid="B37-pharmaceutics-12-00153" ref-type="bibr">37</xref>
,<xref rid="B50-pharmaceutics-12-00153" ref-type="bibr">50</xref>
]. However, moDCs can be induced from blood monocytes in vitro using GM-CSF, and thus are not difficult to collect in high numbers in contrast to cDC1s [<xref rid="B62-pharmaceutics-12-00153" ref-type="bibr">62</xref>
]. Monocytes are also able to differentiate into myeloid-derived suppressor cells (MDSCs), or MDSC-like suppressor cells in some cases, which suppress anti-cancer immunity in both humans and mice [<xref rid="B63-pharmaceutics-12-00153" ref-type="bibr">63</xref>
]. These results indicate that further research is required to elucidate the prospects of human moDCs for DC vaccines.</p>
<p>LCs express langerin, a C-type lectin receptor localized in the epidermis, the outermost layer of the skin [<xref rid="B64-pharmaceutics-12-00153" ref-type="bibr">64</xref>
]. Langerin specifically binds with glycoconjugates, such as the high-mannose structure mannan or the β-glucan on the surface of pathogens [<xref rid="B65-pharmaceutics-12-00153" ref-type="bibr">65</xref>
]. LCs show a strong ability to capture, uptake, and process skin pathogens, as well as epidermal self-antigens. Moreover, LCs have the capacity to induce CD4<sup>+</sup>
T cell responses after migrating to secondary lymphoid tissue [<xref rid="B66-pharmaceutics-12-00153" ref-type="bibr">66</xref>
,<xref rid="B67-pharmaceutics-12-00153" ref-type="bibr">67</xref>
]. They also show a limited CP ability to activate CD8<sup>+</sup>
T cells in mice [<xref rid="B68-pharmaceutics-12-00153" ref-type="bibr">68</xref>
] and in humans langerin-dependently [<xref rid="B69-pharmaceutics-12-00153" ref-type="bibr">69</xref>
]. Since the skin is actively used as a vaccination site, LCs may play a role in specific DC vaccination platforms. Most of these DC classifications have been examined in mice, strongly indicating that experimental confirmation is required for DC vaccines [<xref rid="B31-pharmaceutics-12-00153" ref-type="bibr">31</xref>
,<xref rid="B33-pharmaceutics-12-00153" ref-type="bibr">33</xref>
].</p>
</sec>
<sec id="sec2dot2-pharmaceutics-12-00153"><title>2.2. DC Vaccination</title>
<p>As DCs are one of the rarest populations among leukocytes, DC precursors from patients are differentiated into DCs for DC vaccines. moDCs are the most commonly used DC subset in DC vaccination. Peripheral blood mononuclear cells (PBMCs) collected from a patient are differentiated into moDCs in the presence of GM-CSF and IL-4 [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. BMDCs are also used, but not as frequently as moDCs. CD34<sup>+</sup>
precursor cells are harvested from the bone marrow of patients after administration of GM-CSF; cultured in the presence of GM-CSF, Fms-like tyrosine kinase 3 ligand (Flt3L), and TNF-α; and differentiated into a mixture of moDCs, cDCs, and LCs [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. Likewise, the expansion of cDC1s from circulating BDCA-1<sup>+</sup>
DCs by Flt3L [<xref rid="B72-pharmaceutics-12-00153" ref-type="bibr">72</xref>
] or the isolation of primary circulating CD1c<sup>+</sup>
blood DCs [<xref rid="B73-pharmaceutics-12-00153" ref-type="bibr">73</xref>
] is possible, but the populations of circulating DCs represent less than 1% of PBMCs. Since cDC1s show the most potent ability to initiate CTL immunity against tumors in mice [<xref rid="B74-pharmaceutics-12-00153" ref-type="bibr">74</xref>
], cDC1s are highly recommended for DC vaccines [<xref rid="B71-pharmaceutics-12-00153" ref-type="bibr">71</xref>
]. While the availability of DCs shows marked variability with the aforementioned methods, the preparation method for DCs must be selected by considering both the reliability and efficiency of the harvested DCs. Recently, it was reported that cDC1-like cells were differentiated from human induced pluripotent stem cells (ipDCs) [<xref rid="B75-pharmaceutics-12-00153" ref-type="bibr">75</xref>
]. These cells might be applicable in DC vaccination in the near future. </p>
<p>There are several antigen-loading methods for DC vaccines: antigenic peptides, tumor-associated antigens (TAA), DNA of TAA, viral vectors with TAA insertion, tumor lysates, and tumor-derived mRNA [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. Though pulsing DCs with antigenic peptides is the most comprehensive method, information about the patient’s haplotype and tumor-specific antigenic peptides is indispensable [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. This is also the case for TAA, DNA of TAA, and viral vectors with TAA insertion; the presence of antigenic peptides suitable for the patient’s haplotype must be confirmed before loading [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. In early trials of DC vaccination by TAA, tumor-specific CTL responses were detected [<xref rid="B76-pharmaceutics-12-00153" ref-type="bibr">76</xref>
], indicating that successful CP induced tumor-specific CTLs. While the exact mechanism that accelerates CP efficiency is not yet established, Sipuleucel-T, the only Food and Drug Administration (FDA)-approved therapeutic cancer vaccine, provoked tumor-specific CTL responses against prostate cancer and resulted in better survival rates compared with the controls [<xref rid="B77-pharmaceutics-12-00153" ref-type="bibr">77</xref>
]. These results strongly suggest that the improvement of CP plays a significant role in the results of DC vaccination. Nevertheless, most TAA vaccines were able to induce a tumor-specific CTL response; in most cases, they showed some ability to induce tumor regression when administered alone. Thus, tumor cells appear to be equipped with capabilities to evade the immune system and it is difficult to only destroy these tumor cells by CTLs; thus, the successful combinatorial therapies, such as combinatorial therapies with the immune checkpoint inhibition therapies, are necessary. In this regard, total tumor lysates and tumor-derived mRNA are beneficial, as they do not require information about the patient’s haplotype and inevitably maintain unknown novel tumor antigens [<xref rid="B1-pharmaceutics-12-00153" ref-type="bibr">1</xref>
]. Additionally, the loading of total tumor lysates could neutralize immune-suppressive signals by regulatory T cells (Tregs), which is one of the immune avoiding systems of malignant tumor cells, through activating self-reactive, pro-inflammatory T cells (anti-Tregs) in humans [<xref rid="B78-pharmaceutics-12-00153" ref-type="bibr">78</xref>
]. From a practical standpoint, the purification of mRNA is not convenient compared to the preparation of tumor lysates. Furthermore, electroporation, which is the most efficient method to introduce mRNA into DCs, significantly reduces the number of DCs, which is already limited. These results indicate that the loading of total tumor lysates is an acceptable method when CP is efficient.</p>
<p>CP abilities vary among different subsets and uptake routes of extracellular antigens. Additionally, the particle size of the antigen-loaded beads also affects the CP efficiency of the same antigen in mice [<xref rid="B79-pharmaceutics-12-00153" ref-type="bibr">79</xref>
]. cDC1s showed the most extensive CP efficiencies for all protein uptake routes, such as receptor-mediated endocytosis, pinocytosis, and phagocytosis [<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
]. Murine cDC2s exhibit an effective CP ability similar to that of cDC1s for receptor-mediated endocytosis, but CP is less efficient for the other two uptake routes [<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
]. The CP efficiencies of murine moDCs were equivalent to those of cDC1s for pinocytosis, less efficient for receptor-mediated endocytosis, and not detectable for phagocytosis [<xref rid="B38-pharmaceutics-12-00153" ref-type="bibr">38</xref>
]. As mentioned above, LCs only show CP for receptor-mediated endocytosis. These differences indicate that the loading methods of tumor lysates must be optimized according to the DC subsets in DC vaccination.</p>
</sec>
</sec>
<sec id="sec3-pharmaceutics-12-00153"><title>3. ERAD-Dependent Processing in CP</title>
<sec id="sec3dot1-pharmaceutics-12-00153"><title>3.1. Two Pathways for Cross-Presentation (CP)</title>
<p>Two major pathways involved in the molecular mechanisms of CP are described: the transporter associated with antigen processing (TAP)-dependent pathway and the TAP-independent pathway [<xref rid="B80-pharmaceutics-12-00153" ref-type="bibr">80</xref>
,<xref rid="B81-pharmaceutics-12-00153" ref-type="bibr">81</xref>
,<xref rid="B82-pharmaceutics-12-00153" ref-type="bibr">82</xref>
,<xref rid="B83-pharmaceutics-12-00153" ref-type="bibr">83</xref>
,<xref rid="B84-pharmaceutics-12-00153" ref-type="bibr">84</xref>
]. In the TAP-dependent pathway, extracellular proteins are retro-transported into the cytosol through the cellular membrane and processed by the UPS [<xref rid="B83-pharmaceutics-12-00153" ref-type="bibr">83</xref>
,<xref rid="B84-pharmaceutics-12-00153" ref-type="bibr">84</xref>
] (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). The derived antigenic peptides are transported through the cellular membrane, trimmed, and loaded on MHC I with the aid of the peptide-loading complex (PLC) [<xref rid="B85-pharmaceutics-12-00153" ref-type="bibr">85</xref>
,<xref rid="B86-pharmaceutics-12-00153" ref-type="bibr">86</xref>
,<xref rid="B87-pharmaceutics-12-00153" ref-type="bibr">87</xref>
]. In contrast, in the TAP-independent pathway, extracellular proteins are processed by the lysosomal protease, cathepsin S, and loaded upon MHC I within the endo/lysosomal compartment by a peptide exchange reaction independent of TAP [<xref rid="B88-pharmaceutics-12-00153" ref-type="bibr">88</xref>
] (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). While the TAP-independent pathway has some functions in CP, recent investigations have shown that the TAP-dependent pathway is a major pathway required for CP to regulate cell-mediated immunity. Consequently, immunoproteasome-deficient BMDCs showed impaired CP ability in vitro, as well as in vivo, in a mouse model [<xref rid="B82-pharmaceutics-12-00153" ref-type="bibr">82</xref>
]. The cytoplasmic delivery of exogenous proteins enhanced CP efficiency in a murine model [<xref rid="B89-pharmaceutics-12-00153" ref-type="bibr">89</xref>
]. Expression of PLC was higher in splenic cDC1s than in splenic cDC2s [<xref rid="B44-pharmaceutics-12-00153" ref-type="bibr">44</xref>
], and cDC1s were responsible for both cross-priming [<xref rid="B44-pharmaceutics-12-00153" ref-type="bibr">44</xref>
] and for cross-tolerance [<xref rid="B90-pharmaceutics-12-00153" ref-type="bibr">90</xref>
]. In addition to these two pathways, several other CP-related pathways were found in DCs [<xref rid="B91-pharmaceutics-12-00153" ref-type="bibr">91</xref>
,<xref rid="B92-pharmaceutics-12-00153" ref-type="bibr">92</xref>
]. However, these pathways do not contribute significantly to the ability of CP to initiate naïve CD8<sup>+</sup>
T cells and thus will not be discussed further in this review.</p>
</sec>
<sec id="sec3dot2-pharmaceutics-12-00153"><title>3.2. Molecular Mechanism of the TAP-Dependent Pathway</title>
<sec id="sec3dot2dot1-pharmaceutics-12-00153"><title>3.2.1. Protection of Extracellular Proteins from Lysosomal Degradation</title>
<p>In the TAP-dependent pathway, extracellular proteins are protected from lysosomal proteases and are processed by the UPS [<xref rid="B93-pharmaceutics-12-00153" ref-type="bibr">93</xref>
,<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
,<xref rid="B95-pharmaceutics-12-00153" ref-type="bibr">95</xref>
]. To accommodate this, DCs are equipped with several molecular machineries to protect extracellular proteins from rapid lysosomal degradation. First, DCs express lower amounts of lysosomal proteases (Cathepsin S, L, K, B, D, E, H, and O) with protease inhibitors, compared to macrophages (Mφ), both in vivo (spleen and lymph node) and in vitro (BMDCs and BMMφ) [<xref rid="B96-pharmaceutics-12-00153" ref-type="bibr">96</xref>
]. Additionally, asparagine endopeptidase was also lower in BMDCs, as compared to BMMφ [<xref rid="B96-pharmaceutics-12-00153" ref-type="bibr">96</xref>
].</p>
<p>DCs also delay the maturation of endocytic compartments. In fact, the maturation kinetics of the phagosome occur later in BMDCs than in BMMφ [<xref rid="B97-pharmaceutics-12-00153" ref-type="bibr">97</xref>
], and the phagosomes and endosomes/lysosomes of BMDCs are kept under higher pH (7.5-8) conditions [<xref rid="B98-pharmaceutics-12-00153" ref-type="bibr">98</xref>
,<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
], in comparison to those of Mφ and neutrophils at pH 4.5-7 [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
,<xref rid="B100-pharmaceutics-12-00153" ref-type="bibr">100</xref>
]. The high pH of the endocytic compartments is dependent on both the reduced activity of lysosomal V-ATPase [<xref rid="B101-pharmaceutics-12-00153" ref-type="bibr">101</xref>
] and the enhanced activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). </p>
<p>The V-ATPase is a member of the ATP-dependent family of proton pumps and is ubiquitously localized on the membrane of intracellular compartments and the cell surface [<xref rid="B102-pharmaceutics-12-00153" ref-type="bibr">102</xref>
]. V-ATPase is composed of at least thirteen subunits, consisting of two domains: the V0 domain (a membrane-associated subunit) and the V1 domain (a periphery-associated subunit). The activity of V-ATPase is regulated by the assembly of the V0 and the V1 domains, which is under the control of innate immunity and mammalian targets of rapamycin (mTOR) in BMDCs [<xref rid="B101-pharmaceutics-12-00153" ref-type="bibr">101</xref>
,<xref rid="B103-pharmaceutics-12-00153" ref-type="bibr">103</xref>
]. The incomplete assembly of V-ATPase in DCs results in the protection of extracellular proteins from lysosomal degradation and an increase in CP efficiency [<xref rid="B97-pharmaceutics-12-00153" ref-type="bibr">97</xref>
]. It is well known that mTOR inhibitors, such as rapamycin, convert helper CD4<sup>+</sup>
T cells into regulatory CD4<sup>+</sup>
T cells by attenuating T-cell receptor (TCR) signals [<xref rid="B104-pharmaceutics-12-00153" ref-type="bibr">104</xref>
]. It may also be possible that mTOR inhibitors accelerate CP efficiency without an innate immunity signal, resulting in cross-tolerance by inducing CD8<sup>+</sup>
T cell anergy [<xref rid="B29-pharmaceutics-12-00153" ref-type="bibr">29</xref>
].</p>
<p>Nox2 catalyzes the production of reactive oxygen species (ROS) by transferring one electron to oxygen from NADPH. This occurs at very high rates (mM/s) and typically eliminates pathogens [<xref rid="B105-pharmaceutics-12-00153" ref-type="bibr">105</xref>
]. However, in DCs, ROS reacts with the protons in the luminal space, which causes an active alkalization [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
,<xref rid="B106-pharmaceutics-12-00153" ref-type="bibr">106</xref>
,<xref rid="B107-pharmaceutics-12-00153" ref-type="bibr">107</xref>
]. NOX2 is made up of six subunits: Rac1 or Rac2, gp91phox (containing heme), p22phox, p40phox, p47phox, and p67phox [<xref rid="B107-pharmaceutics-12-00153" ref-type="bibr">107</xref>
]. Active alkalization by NOX2 was shown to be regulated by Rab27a [<xref rid="B106-pharmaceutics-12-00153" ref-type="bibr">106</xref>
], a plasma membrane SNARE protein called VAMP-8 (in both BMDCs and human moDCs) [<xref rid="B108-pharmaceutics-12-00153" ref-type="bibr">108</xref>
], phagosomal SNARE syntaxin-4, and SNAP-23 (in BMDCs) [<xref rid="B109-pharmaceutics-12-00153" ref-type="bibr">109</xref>
]. Rac2 regulated the recruitment and assembly of NOX2 in cDC1s, but not in cDC2s [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
]. Deletion of the Wiskott-Aldrich syndrome protein (WASp) increased Rac2 activity, which resulted in enhanced CP efficiency, both in cDC1s and cDC2s [<xref rid="B110-pharmaceutics-12-00153" ref-type="bibr">110</xref>
]. In contrast, the reduced activity of either gp91phox or p47phox impairs the CP ability of BMDCs [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
]. In cDC1s, sialic acid-binding immunoglobulin-type lectin-G (Siglec-G), a member of the lectin family, recruits Src homology region 2 domain-containing phosphatase-1 (SHP-1) to dephosphorylate p47phox, which inhibits NOX2 activation in phagosomes [<xref rid="B111-pharmaceutics-12-00153" ref-type="bibr">111</xref>
]. NOX2-defective DCs show impaired CP efficiency [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
,<xref rid="B111-pharmaceutics-12-00153" ref-type="bibr">111</xref>
], which strongly suggests the important role of ROS production in CP. </p>
<p>These low acidification states of endocytic compartments are inexpedient for DC homeostasis as they are essential to deactivate and degrade endocytosed pathogens, including many kinds of viruses [<xref rid="B112-pharmaceutics-12-00153" ref-type="bibr">112</xref>
,<xref rid="B113-pharmaceutics-12-00153" ref-type="bibr">113</xref>
,<xref rid="B114-pharmaceutics-12-00153" ref-type="bibr">114</xref>
]. In a normal state, acidification of the endocytic compartments is essential for self-protection of DCs from pathogens. Unaffected endocytic compartments are fused with the lysosome and show acidic conditions in fully mature DCs [<xref rid="B101-pharmaceutics-12-00153" ref-type="bibr">101</xref>
,<xref rid="B111-pharmaceutics-12-00153" ref-type="bibr">111</xref>
], in which the CP efficiency is reduced [<xref rid="B115-pharmaceutics-12-00153" ref-type="bibr">115</xref>
]. Since pathogen infections are avoidable with DC vaccination, pharmacological inhibitors of endocytic acidification (i.e., chloroquine and ammonium chloride) and lysosomal protease inhibitors (i.e., leupeptin) accelerated CP in human moDCs and cDC1s [<xref rid="B116-pharmaceutics-12-00153" ref-type="bibr">116</xref>
,<xref rid="B117-pharmaceutics-12-00153" ref-type="bibr">117</xref>
,<xref rid="B118-pharmaceutics-12-00153" ref-type="bibr">118</xref>
] and murine BMDCs [<xref rid="B119-pharmaceutics-12-00153" ref-type="bibr">119</xref>
], indicating that these pharmacological inhibitors may prove beneficial.</p>
<p>In BMDCs, extracellular proteins are internalized by fluid-phase pinocytosis or scavenger receptor-mediated endocytosis and are rapidly transported into a proteolytic endosome, where they are efficiently degraded by lysosomal proteases, resulting in low CP efficiency [<xref rid="B120-pharmaceutics-12-00153" ref-type="bibr">120</xref>
]. In contrast, the same extracellular proteins, simultaneously internalized by the mannose receptor (MR), are transported into a less-proteolytic endosome, where they are protected from lysosomal proteases, showing higher CP efficiency [<xref rid="B120-pharmaceutics-12-00153" ref-type="bibr">120</xref>
]. Similarly, in human moDCs, a less-proteolytic endosome for higher CP efficiency and a proteolytic endosome for lower CP efficiency operate side-by-side [<xref rid="B118-pharmaceutics-12-00153" ref-type="bibr">118</xref>
,<xref rid="B121-pharmaceutics-12-00153" ref-type="bibr">121</xref>
,<xref rid="B122-pharmaceutics-12-00153" ref-type="bibr">122</xref>
] (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). These two kinds of endosomes are also observed in human LCs; the langerin-bound extracellular proteins, which show effective CP ability, are transported into less-proteolytic endosome. In contrast, the dectin-1-bound extracellular proteins, which show nominal CP ability, are transported into proteolytic endosomes [<xref rid="B69-pharmaceutics-12-00153" ref-type="bibr">69</xref>
]. In addition, the inhibition of lysosomal protease in human moDCs results in effective CP of extracellular proteins once they are transported into the proteolytic endosome [<xref rid="B118-pharmaceutics-12-00153" ref-type="bibr">118</xref>
], indicating that maturation rates differ between these two endosomes. The less-proteolytic endosome may be responsible for preparing the surroundings for extracellular proteins to undergo ERAD-dependent processing (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). In DC vaccination, the accumulation of immunized proteins into this less-proteolytic endosome might accelerate CP efficiency. Since the molecular mechanisms of these distinctions are not clarified yet, further investigations are required to put these compartments to practical use in DC vaccinations. </p>
</sec>
<sec id="sec3dot2dot2-pharmaceutics-12-00153"><title>3.2.2. The Non-Classical Endosome</title>
<p>The cytoplasmic delivery of exogenous proteins largely enhances CP efficiency [<xref rid="B89-pharmaceutics-12-00153" ref-type="bibr">89</xref>
], indicating that the retro-transport of internalized protein from endocytic compartments to the cytosol is one of the rate-limiting processes for an efficient CP. The intracellular transport pathways of extracellular proteins are different among DC subsets, such as cDC1s, moDCs, or BMDCs. The sources of exogenous proteins (e.g., soluble proteins, bead-bound proteins, or proteins expressed by heat-killed microbes) and their uptake routes (e.g., receptor-mediated endocytosis, pinocytosis, or phagocytosis) also vary between these subsets. Additionally, the particle size of the antigen-loaded beads influences the intracellular transport pathways [<xref rid="B79-pharmaceutics-12-00153" ref-type="bibr">79</xref>
]. Regardless of the multiple transport pathways, it is generally assumed that the ERAD machinery contributes to the translocation of extracellular proteins through the cellular membrane to the cytosol, and the ability of this retro-transportation is proportional to the varying CP efficiencies among different DC subsets [<xref rid="B123-pharmaceutics-12-00153" ref-type="bibr">123</xref>
]. While the exact molecular mechanisms of recognition and retro-transport have not been elucidated, extracellular proteins are transported into the cytosol and processed by the UPS [<xref rid="B93-pharmaceutics-12-00153" ref-type="bibr">93</xref>
,<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
,<xref rid="B95-pharmaceutics-12-00153" ref-type="bibr">95</xref>
] (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). ER-resident molecules, including the ERAD machinery, were also found in the phagosome of both Mφ [<xref rid="B124-pharmaceutics-12-00153" ref-type="bibr">124</xref>
,<xref rid="B125-pharmaceutics-12-00153" ref-type="bibr">125</xref>
] and cDCs [<xref rid="B126-pharmaceutics-12-00153" ref-type="bibr">126</xref>
]. The expression level of ERAD-related molecules (i.e., calreticulin, calnexin, SEC61α, SEC61β, SEC61γ, and PDIs) was higher in cDC1s than in cDC2s [<xref rid="B44-pharmaceutics-12-00153" ref-type="bibr">44</xref>
]. While ERAD is carried out in the ER, recent investigations have demonstrated that the ERAD-dependent processing in CP was brought about in the non-classical endocytic compartments, which contained both the ER-resident molecules and the endosome-specific molecules [<xref rid="B93-pharmaceutics-12-00153" ref-type="bibr">93</xref>
,<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
,<xref rid="B95-pharmaceutics-12-00153" ref-type="bibr">95</xref>
] (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). A purified subcellular compartment from moDCs, in which exogenous proteins undergo ERAD-dependent processing in vitro, contained both ER-resident proteins and endosome-specific proteins, as well as the precursor and mature forms of LAMP1 (before and after modification in the Golgi apparatus) [<xref rid="B95-pharmaceutics-12-00153" ref-type="bibr">95</xref>
]. Although the exact mechanisms of transport of ER-resident molecules are not completely understood, recent studies have shown that endosomes directly interact with the ER through the ER-endosome membrane contact site [<xref rid="B127-pharmaceutics-12-00153" ref-type="bibr">127</xref>
] or the ER-Golgi intermediate compartment (ERGIC) [<xref rid="B128-pharmaceutics-12-00153" ref-type="bibr">128</xref>
]. The two organelles exchange a wide variety of molecules during their maturation step. While the precise molecular mechanism of these transport pathways is not clarified yet, it is known that the SNARE proteins Sec22b (in the ERGIC) and syntaxin 4 (in the phagosome) regulate membrane fusion between the ERGIC and the phagosome [<xref rid="B125-pharmaceutics-12-00153" ref-type="bibr">125</xref>
,<xref rid="B129-pharmaceutics-12-00153" ref-type="bibr">129</xref>
]. However, later investigations into the role of Sec22b in CP showed contradictory results [<xref rid="B130-pharmaceutics-12-00153" ref-type="bibr">130</xref>
,<xref rid="B131-pharmaceutics-12-00153" ref-type="bibr">131</xref>
,<xref rid="B132-pharmaceutics-12-00153" ref-type="bibr">132</xref>
]; hence, the exact role of Sec22b in CP requires further examination.</p>
<p>It is not determined yet whether these non-classical endocytic compartments correspond to the less-proteolytic endosome. It might be possible that incorporated proteins are kept in the less-proteolytic endosome, and transport of ERAD-related molecules into these compartments enables ERAD-dependent processing of extracellular proteins before degradation in the lysosome. This non-classical endocytic compartment would play a critical role in DC vaccination. Further investigation is required to clarify the molecular mechanism that shapes this membranous compartment.</p>
</sec>
<sec id="sec3dot2dot3-pharmaceutics-12-00153"><title>3.2.3. Recognition of Extracellular Proteins as ERAD Substrates</title>
<p>As some extracellular proteins in ERAD-dependent processing are derived from infectious pathogens, infected cells, apoptotic cells, or cancers, their activities must be suspended after incorporation into DCs. Furthermore, extracellular proteins are clearly distinguished from endogenous proteins, because the processing of endogenous proteins not only consumes cellular resources, but also results in direct presentation (DP), which competes with CP. However, it is reported that extracellular proteins, such as gelonin (a membrane-impermeable ribosomal inhibitor) or cytochrome C, exhibit their function after retro-transport into the cytosol and inhibit the cellular functions in DCs or Mφ [<xref rid="B69-pharmaceutics-12-00153" ref-type="bibr">69</xref>
]. In general, since retro-transport of cytochrome C from incorporated cells does not induce the apoptosis of DCs, we can infer that retro-transport and degradation of extracellular proteins are tightly linked to each other.</p>
<p>Interestingly, extracellular proteins unfold [<xref rid="B133-pharmaceutics-12-00153" ref-type="bibr">133</xref>
] and specifically associate with ER-resident molecular chaperones in moDCs [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
]. While the precise transport pathways of exogenous proteins in CP are unknown, the abovementioned results support the idea that extracellular proteins are unfolded on the transport pathway to the non-classical endosome [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
]. This unfolding, which is also observed in the substrates of ERAD, distinguishes extracellular proteins from intracellular proteins (<xref ref-type="fig" rid="pharmaceutics-12-00153-f002">Figure 2</xref>
) [<xref rid="B59-pharmaceutics-12-00153" ref-type="bibr">59</xref>
]. Additionally, unfolded proteins lose their activity. Since DCs maintain endocytic compartments under an alkaline pH (7.5–8) [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
], exogenous proteins would not unfold under these conditions. As a means of inducing unfolding, DCs produce ROS to reduce the protons in endocytic compartments. ROS are oxidizing reagents that promote the formation of nonspecific disulfide bonds, resulting in the unfolding of extracellular proteins. In this context, extracellular proteins are specifically associated with PDI in mouse moDCs [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
] and gamma-interferon-inducible lysosomal thiol reductase (GILT)—the only known thiol reductase localized in the lysosomes and phagosomes—which is essential for CP in mouse BMDCs (<xref ref-type="fig" rid="pharmaceutics-12-00153-f002">Figure 2</xref>
) [<xref rid="B135-pharmaceutics-12-00153" ref-type="bibr">135</xref>
]. This suggests a critical role of disulfide bond formation in the unfolding, inactivation, and identification of extracellular proteins in CP. It is also possible that artificial disulfide bond formation in extracellular proteins increases CP efficiency. Recent research has shown that PDI inhibitors induce cancer-specific apoptosis in addition to the activation of cancer-specific T cells and the expansion of memory T cells in a mouse model [<xref rid="B136-pharmaceutics-12-00153" ref-type="bibr">136</xref>
]. In this experiment, cancer-specific T cells were activated by the addition of cancer-specific peptides; therefore, this is not the result of the progression of CP efficiency. Since PDI inhibition increases the recognition of extracellular proteins as substrates of ERAD-like processing, the additive effects seem encouraging.</p>
<p>In addition to PDI, extracellular proteins are also associated with ER-resident molecular chaperones in mouse moDCs, such as BiP, calreticulin [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
], GP96, and ER-degradation enhancing α-mannosidase-like proteins (EDEMs) (our unpublished data). BiP and GP96 recognize unfolded proteins in the ER and play an important role in the retro-transport of these proteins in ERAD (<xref ref-type="fig" rid="pharmaceutics-12-00153-f002">Figure 2</xref>
) [<xref rid="B137-pharmaceutics-12-00153" ref-type="bibr">137</xref>
]. The enhanced CP efficiency of BiP-bound antigens suggests that BiP plays an important role in CP [<xref rid="B17-pharmaceutics-12-00153" ref-type="bibr">17</xref>
]. Moreover, Hsp-complex proteins show high CP efficiency, supporting the hypothesis regarding the critical role of unfolding in CP [<xref rid="B18-pharmaceutics-12-00153" ref-type="bibr">18</xref>
,<xref rid="B19-pharmaceutics-12-00153" ref-type="bibr">19</xref>
]. The results from these mouse models suggest that unfolded extracellular proteins, associated with Hsp, are beneficial to the effects of DC vaccination. Additionally, Hsps are recognized as danger signals, which accelerate the maturation of DCs [<xref rid="B18-pharmaceutics-12-00153" ref-type="bibr">18</xref>
,<xref rid="B19-pharmaceutics-12-00153" ref-type="bibr">19</xref>
].</p>
<p>Exogenous proteins, which bind to the mannose receptor (MR, CD206, or MRC1) [<xref rid="B120-pharmaceutics-12-00153" ref-type="bibr">120</xref>
,<xref rid="B138-pharmaceutics-12-00153" ref-type="bibr">138</xref>
], langerin (CD207) [<xref rid="B69-pharmaceutics-12-00153" ref-type="bibr">69</xref>
], CD205 [<xref rid="B5-pharmaceutics-12-00153" ref-type="bibr">5</xref>
], or CLEC9A [<xref rid="B139-pharmaceutics-12-00153" ref-type="bibr">139</xref>
,<xref rid="B140-pharmaceutics-12-00153" ref-type="bibr">140</xref>
], showed high CP efficiency. Since all these receptors recognize sugar chain structures [<xref rid="B65-pharmaceutics-12-00153" ref-type="bibr">65</xref>
,<xref rid="B141-pharmaceutics-12-00153" ref-type="bibr">141</xref>
], it is possible that these lectin-bound proteins are also recognized as glycosylated ERAD substrates by ER-resident lectins, increasing CP efficiency. Conversely, MR-deficient BMDCs from mice showed poor CP ability for glycosylated proteins, which also supports this hypothesis [<xref rid="B138-pharmaceutics-12-00153" ref-type="bibr">138</xref>
]. In CP, large amounts of exogenous proteins are mature glycoproteins with high numbers of mannose-type oligosaccharide chains, which are preferentially recognized by ER-resident lectins as substrates for ERAD (<xref ref-type="fig" rid="pharmaceutics-12-00153-f002">Figure 2</xref>
) [<xref rid="B142-pharmaceutics-12-00153" ref-type="bibr">142</xref>
]. Thus, it is possible that mannose-type oligosaccharide chains function as signals for exogenous proteins. While sugar chains play an important role in ERAD, the role of sugar chains in CP is not understood well. A recent investigation suggested that optimal glycosylation of antigenic proteins in vitro might serve as a useful adjuvant for DC vaccination [<xref rid="B143-pharmaceutics-12-00153" ref-type="bibr">143</xref>
].</p>
</sec>
<sec id="sec3dot2dot4-pharmaceutics-12-00153"><title>3.2.4. The Translocon in CP</title>
<p>Following recognition in the non-classical endocytic compartment, extracellular proteins are retro-transported through the cellular membrane into the cytosol. Together with retro-translocation, the extracellular proteins are ubiquitinated and processed by the UPS. Two retro-translocons are described in the ERAD: the HRD1 complex [<xref rid="B144-pharmaceutics-12-00153" ref-type="bibr">144</xref>
] and the Sec61 complex [<xref rid="B145-pharmaceutics-12-00153" ref-type="bibr">145</xref>
,<xref rid="B146-pharmaceutics-12-00153" ref-type="bibr">146</xref>
]. During retro-transport of CP, accumulating evidence suggests that the Sec61 complex plays a significant role. SEC61 α and β are associated with exogenous proteins in moDCs and BMDCs [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
]. Inhibition of SEC61 by siRNA impairs CP ability in BMDCs [<xref rid="B125-pharmaceutics-12-00153" ref-type="bibr">125</xref>
], moDCs [<xref rid="B126-pharmaceutics-12-00153" ref-type="bibr">126</xref>
,<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
], cDC1s, and cDC2s [<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
]. Additionally, transport of the SEC61 complex into the endosome strongly inhibits CP in cDC1s, but not in cDC2s, indicating that extracellular proteins are retro-transported into the cytosol through the SEC61 complex and that the ERAD-dependent processing in CP was not carried out in the ER or the classical endosome, but in a non-classical endosome with ER-resident molecules [<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
]. Noticeably, exotoxin A, which binds the cytosolic N-terminal domain of Sec61 α and a nearby channel pore [<xref rid="B147-pharmaceutics-12-00153" ref-type="bibr">147</xref>
,<xref rid="B148-pharmaceutics-12-00153" ref-type="bibr">148</xref>
,<xref rid="B149-pharmaceutics-12-00153" ref-type="bibr">149</xref>
], inhibits the retro-transport of extracellular proteins to the cytosol both in vivo and in vitro [<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
,<xref rid="B150-pharmaceutics-12-00153" ref-type="bibr">150</xref>
], strongly indicating that the Sec61 complex plays a major role in the retro-transport of extracellular proteins in CP. It is possible that the substrates of the ERAD-dependent processing in CP are preferentially exported through the SEC61 complex, since they are simple, unstructured proteins without a transmembrane domain [<xref rid="B151-pharmaceutics-12-00153" ref-type="bibr">151</xref>
]. Pharmacological inhibition of the valosin-containing protein (VCP) and SEC61 recruitment by PYR-41 or thalidomide-mediated NF-κB inactivation decreased CP efficiency in BMDCs [<xref rid="B152-pharmaceutics-12-00153" ref-type="bibr">152</xref>
]. In contrast, in both BMDCs and moDCs, the retro-transport of extracellular proteins is independent of Derlin-1 [<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
,<xref rid="B95-pharmaceutics-12-00153" ref-type="bibr">95</xref>
], which is a component of the HRD1 complex [<xref rid="B144-pharmaceutics-12-00153" ref-type="bibr">144</xref>
]. Additionally, siRNA-mediated depletion of HRD1 in BMDCs impaired CP efficiency slightly, together with a robust impairment of MHC II presentation, suggesting that these results are nonspecific effects related to the downregulation of Hrd1 [<xref rid="B94-pharmaceutics-12-00153" ref-type="bibr">94</xref>
]. Nevertheless, the role of the HRD1 complex in CP has not been characterized as precisely as that of the SEC61 complex. It is reasonable to speculate, however, that the HRD1 complex may exert an effect on CP. In fact, our group also detected components of the HRD1 complex in a purified microsome for CP (personal unpublished data). This suggests that DCs may utilize different retro-translocon machinery for CP, such as the SEC61 complex and the HRD1 complex, depending on the condition of the exogenous proteins. However, further investigation is required to confirm this assumption. </p>
<p>Only a small number of molecules have been shown to play a role in CP, compared to the retro-transport machinery. VCP was specifically associated with exogenous proteins in moDCs and BMDCs [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
], and its inhibition abrogated CP ability in these DC subsets [<xref rid="B95-pharmaceutics-12-00153" ref-type="bibr">95</xref>
,<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
,<xref rid="B138-pharmaceutics-12-00153" ref-type="bibr">138</xref>
,<xref rid="B150-pharmaceutics-12-00153" ref-type="bibr">150</xref>
], indicating that p97 provides the energy to pull lumenal proteins into the cytosol. Similarly, carboxyl terminus Hsp70/90 interacting protein (CHIP), an E3 ubiquitin ligase, associated with CP substrates and played an essential role in CP in moDCs [<xref rid="B134-pharmaceutics-12-00153" ref-type="bibr">134</xref>
]. Tumor susceptibility gene 101 (TSG101), which is a dominant-negative regulator of polyubiquitination [<xref rid="B153-pharmaceutics-12-00153" ref-type="bibr">153</xref>
], colocalized with CP substrates and negatively regulated CP efficiency in BMDCs [<xref rid="B138-pharmaceutics-12-00153" ref-type="bibr">138</xref>
]. Cytosolic molecular chaperones, such as Hsp70 and Hsp90, were associated with CP substrates after retro-transport and were required for effective CP [<xref rid="B133-pharmaceutics-12-00153" ref-type="bibr">133</xref>
,<xref rid="B154-pharmaceutics-12-00153" ref-type="bibr">154</xref>
,<xref rid="B155-pharmaceutics-12-00153" ref-type="bibr">155</xref>
]. Altogether, these results indicate that ERAD-related molecules also play an important role in CP, suggesting that other ERAD-related molecules are also shared in CP. However, excessive ER stress results in inflammation or an immunosuppressive phenotype, which promotes cancer escape from the immune system. Further investigation is necessary to apply ERAD-dependent processing to antigen-loading methods. </p>
</sec>
</sec>
</sec>
<sec id="sec4-pharmaceutics-12-00153"><title>4. Peptide Loading onto MHC I</title>
<p>After processing, precursor peptides are trimmed to a suitable length of approximately 10 amino acids by cytosolic aminopeptidase (tripeptidyl peptidase 2; TPP2) [<xref rid="B156-pharmaceutics-12-00153" ref-type="bibr">156</xref>
] and are transported through the TAP complex into the ER or the non-classical endosome [<xref rid="B80-pharmaceutics-12-00153" ref-type="bibr">80</xref>
,<xref rid="B81-pharmaceutics-12-00153" ref-type="bibr">81</xref>
,<xref rid="B125-pharmaceutics-12-00153" ref-type="bibr">125</xref>
,<xref rid="B127-pharmaceutics-12-00153" ref-type="bibr">127</xref>
,<xref rid="B154-pharmaceutics-12-00153" ref-type="bibr">154</xref>
,<xref rid="B157-pharmaceutics-12-00153" ref-type="bibr">157</xref>
]. After transport into lumenal compartments, precursor peptides are further trimmed to a fitting length for MHC I presentation by ER-resident amino-peptidases (ERAP1 and ERAP2) [<xref rid="B158-pharmaceutics-12-00153" ref-type="bibr">158</xref>
,<xref rid="B159-pharmaceutics-12-00153" ref-type="bibr">159</xref>
] or insulin-responsive aminopeptidase (IRAP) [<xref rid="B158-pharmaceutics-12-00153" ref-type="bibr">158</xref>
,<xref rid="B159-pharmaceutics-12-00153" ref-type="bibr">159</xref>
,<xref rid="B160-pharmaceutics-12-00153" ref-type="bibr">160</xref>
]. This indicates that precursor peptides are transported into the ER and the endosomes and are then loaded onto MHC I [<xref rid="B159-pharmaceutics-12-00153" ref-type="bibr">159</xref>
]. Moreover, IRAP is localized in the Rab14-positive endocytic compartments, which further suggests that peptide loading may occur in the non-classical endocytic compartments [<xref rid="B159-pharmaceutics-12-00153" ref-type="bibr">159</xref>
,<xref rid="B161-pharmaceutics-12-00153" ref-type="bibr">161</xref>
]. </p>
<p>The endocytic compartment is equipped with two kinds of MHC I molecules; one is a newly synthesized MHC I molecule without an antigenic peptide [<xref rid="B80-pharmaceutics-12-00153" ref-type="bibr">80</xref>
,<xref rid="B81-pharmaceutics-12-00153" ref-type="bibr">81</xref>
,<xref rid="B108-pharmaceutics-12-00153" ref-type="bibr">108</xref>
,<xref rid="B111-pharmaceutics-12-00153" ref-type="bibr">111</xref>
,<xref rid="B125-pharmaceutics-12-00153" ref-type="bibr">125</xref>
,<xref rid="B135-pharmaceutics-12-00153" ref-type="bibr">135</xref>
,<xref rid="B149-pharmaceutics-12-00153" ref-type="bibr">149</xref>
,<xref rid="B162-pharmaceutics-12-00153" ref-type="bibr">162</xref>
], and the other is recycled MHC I from the cell surface with antigenic peptides [<xref rid="B130-pharmaceutics-12-00153" ref-type="bibr">130</xref>
,<xref rid="B163-pharmaceutics-12-00153" ref-type="bibr">163</xref>
]. Newly synthesized MHC I are loaded with an antigenic peptide with the aid of PLC as DP, which ensures the variation of antigenic peptides. Alternatively, recycled MHC I are loaded with antigenic peptide by the peptide exchange reaction, in which old antigenic peptides are released upon recycled MHC I in the acidic compartments of the endosome/lysosome and are substituted by antigenic peptides [<xref rid="B83-pharmaceutics-12-00153" ref-type="bibr">83</xref>
,<xref rid="B84-pharmaceutics-12-00153" ref-type="bibr">84</xref>
]. In the peptide exchange reaction, the antigenic peptides with higher affinities for MHC I are preferentially selected. As a result, the variety of antigenic peptides decreases. The non-classical endosome is not as acidic as the endo/lysosome, so this compartment is unable to carry out an efficient peptide exchange reaction. Additionally, the non-classical endosome is equipped with MHC I and PLC [<xref rid="B93-pharmaceutics-12-00153" ref-type="bibr">93</xref>
]. Together, these results strongly suggest that peptide loading in CP is carried out by newly synthesized MHC I in the ER or in the non-classical endocytic compartments, which also supports the notion that the effective transport of extracellular proteins into the non-classical endocytic compartments is one of the most important requirements for DC vaccination. While the source of MHC I has not been precisely determined yet, the results of cytoplasmic delivery of exogenous proteins [<xref rid="B89-pharmaceutics-12-00153" ref-type="bibr">89</xref>
] indicate that the amounts of MHC I in DCs are sufficient, and that loading onto MHC I is not a rate-determining step in CP. </p>
</sec>
<sec id="sec5-pharmaceutics-12-00153"><title>5. Improvements in CP Efficiency by ERAD-Dependent Processing </title>
<p>Since ERAD and the ERAD-dependent processing in CP share several cellular machineries, the molecular machinery of ERAD would be useful to improve CP efficiency. Notably, the recognition of extracellular proteins as the ERAD substrate would improve the retro-transport of extracellular proteins, a rate-limiting step of CP, which may contribute to the success of DC vaccinations. As previously mentioned, ex vivo methods, which enhance recognition of extracellular proteins by ER-resident molecular chaperones, would significantly improve the effects of DC vaccinations. It is also possible that the properties of extracellular proteins (unfolded, hyper-disulfated, or glycosylated) are one of the keys for effective DC vaccination (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). </p>
<p>While activation of the non-canonical UPR is essential for CP in cDC1s [<xref rid="B164-pharmaceutics-12-00153" ref-type="bibr">164</xref>
], overactivation of the UPR in DCs sometimes has the opposite effect [<xref rid="B164-pharmaceutics-12-00153" ref-type="bibr">164</xref>
,<xref rid="B165-pharmaceutics-12-00153" ref-type="bibr">165</xref>
]. Although ROS play an essential role in antimicrobial defense [<xref rid="B105-pharmaceutics-12-00153" ref-type="bibr">105</xref>
] and take part in CP by actively alkalizing the luminal space [<xref rid="B99-pharmaceutics-12-00153" ref-type="bibr">99</xref>
,<xref rid="B106-pharmaceutics-12-00153" ref-type="bibr">106</xref>
,<xref rid="B107-pharmaceutics-12-00153" ref-type="bibr">107</xref>
] or by the membrane rupture pathway [<xref rid="B92-pharmaceutics-12-00153" ref-type="bibr">92</xref>
], ROS oxidize the cellular membrane and produce peroxidized lipids. In cDCs, dysregulated activation of UPR is induced by peroxidized lipids, leading to aberrant triglyceride synthesis and blunt anti-cancer immunity [<xref rid="B165-pharmaceutics-12-00153" ref-type="bibr">165</xref>
]. The oxidized lipids also ligate TLR4 and cause inflammation [<xref rid="B166-pharmaceutics-12-00153" ref-type="bibr">166</xref>
,<xref rid="B167-pharmaceutics-12-00153" ref-type="bibr">167</xref>
]. Additionally, in cDC1s, overactivation of the UPR resulted in decreased expression of tapasin and hampered CP [<xref rid="B164-pharmaceutics-12-00153" ref-type="bibr">164</xref>
]. In murine herpes simplex virus (HSV) type 2 infection experiments, viral glycoprotein D increased ER stress and inhibited functions of BMDCs, such as migration and initiation of naïve T cells [<xref rid="B168-pharmaceutics-12-00153" ref-type="bibr">168</xref>
]. This also supports the notion that the overactivation of UPR impairs both the antigen presentation and the immunoregulatory activity of DCs. Cancer UPR can induce UPR in cancer-infiltrating immune cells extrinsically, an action called transmission of ER stress (TES) [<xref rid="B62-pharmaceutics-12-00153" ref-type="bibr">62</xref>
,<xref rid="B169-pharmaceutics-12-00153" ref-type="bibr">169</xref>
]. TES imparts BMDCs with a mixed pro-inflammatory/immunosuppressive phenotype to promote cancer survival and outgrowth, although the precise molecular mechanisms are not clarified yet [<xref rid="B62-pharmaceutics-12-00153" ref-type="bibr">62</xref>
]. Moreover, during TES, monocytes differentiate into MDSCs, which accumulate in cancers and block protective anti-cancer T cell responses in both humans and mice [<xref rid="B63-pharmaceutics-12-00153" ref-type="bibr">63</xref>
]. All of these results indicate that the molecular machinery of ERAD-dependent processing has great potential to increase CP efficiency, and further investigation is essential to make good use of this for DC vaccines.</p>
</sec>
<sec id="sec6-pharmaceutics-12-00153"><title>6. DC Maturation</title>
<p>CP efficiency is one of the most important factors in DC vaccination, as CTLs are not only activated by peptide-loaded MHC I. To induce CTLs fully, costimulatory molecules (CD40, CD80, and CD86) on the DC surface are essential [<xref rid="B4-pharmaceutics-12-00153" ref-type="bibr">4</xref>
,<xref rid="B5-pharmaceutics-12-00153" ref-type="bibr">5</xref>
,<xref rid="B6-pharmaceutics-12-00153" ref-type="bibr">6</xref>
,<xref rid="B7-pharmaceutics-12-00153" ref-type="bibr">7</xref>
]. Additionally, to preserve cancer-specific CD8<sup>+</sup>
T cells, sufficient cytokines from helper T cells are required to expand CTLs into effector-memory CD8<sup>+</sup>
T cells [<xref rid="B41-pharmaceutics-12-00153" ref-type="bibr">41</xref>
]. Effector-memory CD8<sup>+</sup>
T cells play a crucial role in long-lasting cancer immunity and immunosurveillance for cancer redevelopment [<xref rid="B170-pharmaceutics-12-00153" ref-type="bibr">170</xref>
,<xref rid="B171-pharmaceutics-12-00153" ref-type="bibr">171</xref>
]. While cDC1s and moDCs are capable of effective CP in steady state, CP without costimulatory molecules and appropriate cytokines induces T cell cross-tolerance, which plays a significant role in suppression immunotherapy [<xref rid="B7-pharmaceutics-12-00153" ref-type="bibr">7</xref>
]. DCs express these costimulatory molecules and key cytokines only after activation by ligation of PRRs [<xref rid="B172-pharmaceutics-12-00153" ref-type="bibr">172</xref>
,<xref rid="B173-pharmaceutics-12-00153" ref-type="bibr">173</xref>
] or receiving several kinds of cytokines [<xref rid="B174-pharmaceutics-12-00153" ref-type="bibr">174</xref>
,<xref rid="B175-pharmaceutics-12-00153" ref-type="bibr">175</xref>
]. After detecting stimulation, DCs undergo a developmental program called maturation, transitioning from immature antigen-capturing DCs to mature antigen-presenting DCs, accompanied by morphological changes [<xref rid="B176-pharmaceutics-12-00153" ref-type="bibr">176</xref>
]. DCs migrate into draining lymph nodes to shape the fittest adoptive immune response according to stimulation by PRRs or cytokines [<xref rid="B176-pharmaceutics-12-00153" ref-type="bibr">176</xref>
]. Some immune response modifiers, such as imiquimod [<xref rid="B177-pharmaceutics-12-00153" ref-type="bibr">177</xref>
], BCG, or picibanil [<xref rid="B178-pharmaceutics-12-00153" ref-type="bibr">178</xref>
], which are approved as anti-cancer drugs, activate innate immunity and facilitate DC activation and maturation. These results indicate that the activation of innate immunity plays an essential role in activation immunotherapy, including DC vaccination.</p>
<p>Maturation transiently enhances the incorporation of extracellular proteins [<xref rid="B179-pharmaceutics-12-00153" ref-type="bibr">179</xref>
], thereby increasing CP efficiency [<xref rid="B176-pharmaceutics-12-00153" ref-type="bibr">176</xref>
]. The ligation of TLR4 in BMDCs promotes CP by several molecular mechanisms. First, internalization of extracellular proteins is increased [<xref rid="B115-pharmaceutics-12-00153" ref-type="bibr">115</xref>
]. Second, phagosome/endosome maturation is delayed, which protects extracellular proteins from degradation by the lysosome [<xref rid="B180-pharmaceutics-12-00153" ref-type="bibr">180</xref>
]. Additionally, the activation of TLR4 downregulates vacuolar proton ATPase, cathepsin B, D, S, and Rab7 [<xref rid="B97-pharmaceutics-12-00153" ref-type="bibr">97</xref>
,<xref rid="B180-pharmaceutics-12-00153" ref-type="bibr">180</xref>
,<xref rid="B181-pharmaceutics-12-00153" ref-type="bibr">181</xref>
] and upregulates MHC I, PLC, and UPS molecules [<xref rid="B181-pharmaceutics-12-00153" ref-type="bibr">181</xref>
]. The activation of either TLR2 or TLR4 accelerates the fusion between phagosomes and MHC I-containing recycling endosomes [<xref rid="B130-pharmaceutics-12-00153" ref-type="bibr">130</xref>
,<xref rid="B182-pharmaceutics-12-00153" ref-type="bibr">182</xref>
]. In cDC1s, TLR3 stimulation enhances the uptake of apoptotic cells [<xref rid="B183-pharmaceutics-12-00153" ref-type="bibr">183</xref>
], and stimulation of NOD1 and NOD2 accelerates CP by upregulating PLC and ERAD-related molecules [<xref rid="B184-pharmaceutics-12-00153" ref-type="bibr">184</xref>
]. In human moDCs, NODs and TLR2 stimulation enhanced CP by positively regulating MHC I peptide loading and immunoproteasome stability [<xref rid="B185-pharmaceutics-12-00153" ref-type="bibr">185</xref>
]. To the contrary, neither TLR4, Myd88, nor TRIF-deficient BMDCs showed decreased CP efficiencies in mice [<xref rid="B159-pharmaceutics-12-00153" ref-type="bibr">159</xref>
]. Extracellular proteins in endocytic compartments without danger signals are self-proteins; therefore, they are promptly degraded in the lysosome, resulting in lower CP efficiency (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). In contrast, extracellular proteins with danger signals would be non-self-proteins; hence, they undergo ERAD-dependent processing and show higher CP efficiency (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). These results suggest that the activation of innate immunity may cause delayed maturation of endocytic compartments with non-self-proteins [<xref rid="B118-pharmaceutics-12-00153" ref-type="bibr">118</xref>
,<xref rid="B119-pharmaceutics-12-00153" ref-type="bibr">119</xref>
,<xref rid="B120-pharmaceutics-12-00153" ref-type="bibr">120</xref>
,<xref rid="B121-pharmaceutics-12-00153" ref-type="bibr">121</xref>
,<xref rid="B122-pharmaceutics-12-00153" ref-type="bibr">122</xref>
], resulting in improvements to the CP efficiencies of non-self-proteins in addition to the induction of DC maturation.</p>
<p>After the transient augmentation of extracellular protein incorporation, DCs shut the incorporations down, and CP efficiencies are finally depressed [<xref rid="B176-pharmaceutics-12-00153" ref-type="bibr">176</xref>
]. In BMDCs and cDC1s, expression of TFEB, a lysosomal master regulator activated by the innate immunity signal [<xref rid="B186-pharmaceutics-12-00153" ref-type="bibr">186</xref>
], negatively regulates CP ability by upregulating lysosomal proteases and promoting the maturation of lysosomes [<xref rid="B111-pharmaceutics-12-00153" ref-type="bibr">111</xref>
]. TFEB is reportedly activated by NOX2 lysosomal alkalization and, when activated, directly initiates transcription of costimulatory molecules [<xref rid="B187-pharmaceutics-12-00153" ref-type="bibr">187</xref>
]. Additionally, in mice, TFEB controls transcription of several cytokines and chemokines, including IL- 1β, IL-6, TNF-α, and CCL5 [<xref rid="B186-pharmaceutics-12-00153" ref-type="bibr">186</xref>
], indicating that activation of TFEB controls the maturation steps of DCs. After receiving an innate immunity signal, DCs inhibit the maturation of endocytic compartments by several molecular mechanisms including ROS production and retro-transport of extracellular proteins into the cytosol for CP. Then, ROS activate TFEB, and TFEB promotes the maturation of lysosomes that exterminate pathogens [<xref rid="B111-pharmaceutics-12-00153" ref-type="bibr">111</xref>
] and starts the transcription of costimulatory molecules and cytokines for cross-priming [<xref rid="B186-pharmaceutics-12-00153" ref-type="bibr">186</xref>
,<xref rid="B187-pharmaceutics-12-00153" ref-type="bibr">187</xref>
]. The accelerated activation of V-ATPase after the ligation of TLR4 in BMDCs [<xref rid="B101-pharmaceutics-12-00153" ref-type="bibr">101</xref>
] is inconsistent with the results from the previously mentioned effects of innate immunity, and is the result of the time difference in the maturation of the lysosome (<xref ref-type="fig" rid="pharmaceutics-12-00153-f001">Figure 1</xref>
). The role of TFEB in CP indicates that the maturation step of DCs is another rate-limiting step for CP, which strongly suggests the importance of the time sequences of DC maturation for DC vaccination, particularly the time interval between administration of extracellular proteins and maturation signals. </p>
<p>In addition to CP efficiency, the maturation status of DCs influences the selection of the administration route. Under non-artificial conditions, DCs incorporate antigenic proteins in the tumor site, start maturation, and migrate into the T cell-rich zone of draining lymph nodes to induce an immune response by activating tumor specific CTLs [<xref rid="B188-pharmaceutics-12-00153" ref-type="bibr">188</xref>
,<xref rid="B189-pharmaceutics-12-00153" ref-type="bibr">189</xref>
]. The tumor site resident cDC1s secrete CXCL9/10 chemokine to induce these tumor-specific CTLs [<xref rid="B12-pharmaceutics-12-00153" ref-type="bibr">12</xref>
]. These specializations (antigen incorporation, cross-priming, and chemokine secretion) are determined by the localizations and the maturation status of DCs [<xref rid="B190-pharmaceutics-12-00153" ref-type="bibr">190</xref>
]. However, both lymph nodes migrated cDC1s and the tumor site resident cDC1s play significant roles in anti-tumor immune response [<xref rid="B11-pharmaceutics-12-00153" ref-type="bibr">11</xref>
], the maturation status of DCs and administration route (intranodal, intradermal, intravenous, intralymphatic, etc.) were uniformly regulated in DC vaccination. It was recently reported that migration of DCs into tumor nests was under development as a human cancer therapy, but without significant success [<xref rid="B191-pharmaceutics-12-00153" ref-type="bibr">191</xref>
]. These results strongly suggest that selection of the administration route, in consideration of the maturation status of DCs, is one strategy to overcome the obstacles associated with DC vaccination. </p>
<p>All these results indicate that DC maturation is critical to the effect of DC vaccination, since the maturation step has determinative effects on cross-priming efficiency, the expansion of effector-memory CD8<sup>+</sup>
T cells, and the infiltration of activated CTLs, all of which play important roles in tumor immunity.</p>
</sec>
<sec sec-type="conclusions" id="sec7-pharmaceutics-12-00153"><title>7. Conclusions</title>
<p>Antigen presentation, especially by CP, is one of the most important rate-determining steps for DC vaccination and suppression immunotherapies. Despite the essential role of CP in an adaptive immunity, its precise molecular mechanism is not yet characterized. The intracellular transport pathways of extracellular proteins differ among DC subsets, depending on the properties of exogenous proteins and their route of uptake. Despite these differences, recent research has revealed that limited lysosomal degradation and ERAD-dependent processing play pivotal roles in the production of the antigenic peptide from extracellular proteins in CP. The role of ERAD-dependent processing in CP strongly suggests that ex vivo methods, which enhance recognition of extracellular proteins as the ERAD substrate, would significantly improve the effect of DC vaccination. On the contrary, the overactivation of UPR impairs both antigen presentation and the immunoregulatory activity of DCs, and even differentiates monocytes into MDSCs or MDSC-like cells [<xref rid="B62-pharmaceutics-12-00153" ref-type="bibr">62</xref>
,<xref rid="B63-pharmaceutics-12-00153" ref-type="bibr">63</xref>
]. This indicates that the application of ERAD-dependent molecular machinery may have extensive potential to improve CP efficiency. To this end, our laboratory is purifying subcellular compartments in which exogenous antigens undergo ERAD-dependent degradation by DCs in different cell subsets, uptake routes, or maturation statuses, according to our previous methods [<xref rid="B93-pharmaceutics-12-00153" ref-type="bibr">93</xref>
]. These results will clarify the detailed molecular mechanisms of CP and may contribute to the improved design of DC vaccines. Further studies are needed regarding the molecular machinery of non-canonical UPR to optimize it for DC vaccines. Additionally, the time sequences between the administration of extracellular proteins and the maturation signals should be appropriately arranged considering the maturation step of DCs, which regulates ERAD-dependent processing. In conclusion, accumulating evidence suggests that the molecular mechanisms of ERAD-dependent processing can be applied to improve the efficacy of DC vaccination, but not before the precise role of ERAD-dependent processing in CP is determined.</p>
</sec>
</body>
<back><notes><title>Funding</title>
<p>This study was funded by the Takasaki University of Health and Welfare, Gunma, Japan; and Japan Society for the Promotion of Science (JSPS) KAKENHI, grant number 19K02336.</p>
</notes>
<notes notes-type="COI-statement"><title>Conflicts of Interest</title>
<p>The authors declare no conflict of interest.</p>
</notes>
<ref-list><title>References</title>
<ref id="B1-pharmaceutics-12-00153"><label>1.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Finn</surname>
<given-names>O.J.</given-names>
</name>
</person-group>
<article-title>Human tumor antigens yesterday, today, and tomorrow</article-title>
<source>Cancer Immunol. Res.</source>
<year>2017</year>
<volume>5</volume>
<fpage>347</fpage>
<lpage>354</lpage>
<pub-id pub-id-type="doi">10.1158/2326-6066.CIR-17-0112</pub-id>
<pub-id pub-id-type="pmid">28465452</pub-id>
</element-citation>
</ref>
<ref id="B2-pharmaceutics-12-00153"><label>2.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stanley</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Tumour virus vaccines: Hepatitis B virus and human papillomavirus</article-title>
<source>Philos. Trans. R. Soc. B Biol. Sci.</source>
<year>2016</year>
<volume>372</volume>
<fpage>1732</fpage>
<pub-id pub-id-type="doi">10.1098/rstb.2016.0268</pub-id>
</element-citation>
</ref>
<ref id="B3-pharmaceutics-12-00153"><label>3.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>D.S.</given-names>
</name>
<name><surname>Mellman</surname>
<given-names>I.</given-names>
</name>
</person-group>
<article-title>Elements of cancer immunity and the cancer-immune set point</article-title>
<source>Nature</source>
<year>2017</year>
<volume>541</volume>
<fpage>321</fpage>
<lpage>330</lpage>
<pub-id pub-id-type="doi">10.1038/nature21349</pub-id>
<pub-id pub-id-type="pmid">28102259</pub-id>
</element-citation>
</ref>
<ref id="B4-pharmaceutics-12-00153"><label>4.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sigal</surname>
<given-names>L.J.</given-names>
</name>
<name><surname>Crotty</surname>
<given-names>S.</given-names>
</name>
<name><surname>Andino</surname>
<given-names>R.</given-names>
</name>
<name><surname>Rock</surname>
<given-names>K.L.</given-names>
</name>
</person-group>
<article-title>Cytotoxic T cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen</article-title>
<source>Nature</source>
<year>1999</year>
<volume>398</volume>
<fpage>77</fpage>
<lpage>80</lpage>
<pub-id pub-id-type="doi">10.1038/18038</pub-id>
<pub-id pub-id-type="pmid">10078533</pub-id>
</element-citation>
</ref>
<ref id="B5-pharmaceutics-12-00153"><label>5.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bonifaz</surname>
<given-names>L.</given-names>
</name>
<name><surname>Bonnyay</surname>
<given-names>D.</given-names>
</name>
<name><surname>Mahnke</surname>
<given-names>K.</given-names>
</name>
<name><surname>Rivera</surname>
<given-names>M.</given-names>
</name>
<name><surname>Nussenzweig</surname>
<given-names>M.C.</given-names>
</name>
<name><surname>Steinman</surname>
<given-names>R.M.</given-names>
</name>
</person-group>
<article-title>Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance</article-title>
<source>J. Exp. Med.</source>
<year>2002</year>
<volume>196</volume>
<fpage>1627</fpage>
<lpage>1638</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20021598</pub-id>
<pub-id pub-id-type="pmid">12486105</pub-id>
</element-citation>
</ref>
<ref id="B6-pharmaceutics-12-00153"><label>6.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Den Haan</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Bevan</surname>
<given-names>M.J.</given-names>
</name>
</person-group>
<article-title>Antigen presentation to CD8+ T cells: Cross-priming in infectious diseases</article-title>
<source>Curr. Opin. Immunol.</source>
<year>2001</year>
<volume>13</volume>
<fpage>437</fpage>
<lpage>441</lpage>
<pub-id pub-id-type="doi">10.1016/S0952-7915(00)00238-7</pub-id>
<pub-id pub-id-type="pmid">11498299</pub-id>
</element-citation>
</ref>
<ref id="B7-pharmaceutics-12-00153"><label>7.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heath</surname>
<given-names>W.R.</given-names>
</name>
<name><surname>Carbone</surname>
<given-names>F.R.</given-names>
</name>
</person-group>
<article-title>Cross-presentation in viral immunity and self-tolerance</article-title>
<source>Nat. Rev. Immunol.</source>
<year>2001</year>
<volume>1</volume>
<fpage>126</fpage>
<lpage>134</lpage>
<pub-id pub-id-type="doi">10.1038/35100512</pub-id>
<pub-id pub-id-type="pmid">11905820</pub-id>
</element-citation>
</ref>
<ref id="B8-pharmaceutics-12-00153"><label>8.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mittal</surname>
<given-names>D.</given-names>
</name>
<name><surname>Gubin</surname>
<given-names>M.M.</given-names>
</name>
<name><surname>Schreiber</surname>
<given-names>R.D.</given-names>
</name>
<name><surname>Smyth</surname>
<given-names>M.J.</given-names>
</name>
</person-group>
<article-title>New insights into cancer immunoediting and its three components phases-elimination, equilibrium and escape</article-title>
<source>Curr. Opin. Immunol.</source>
<year>2014</year>
<volume>27</volume>
<fpage>16</fpage>
<lpage>25</lpage>
<pub-id pub-id-type="doi">10.1016/j.coi.2014.01.004</pub-id>
<pub-id pub-id-type="pmid">24531241</pub-id>
</element-citation>
</ref>
<ref id="B9-pharmaceutics-12-00153"><label>9.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lennerz</surname>
<given-names>V.</given-names>
</name>
<name><surname>Fatho</surname>
<given-names>M.</given-names>
</name>
<name><surname>Gentilini</surname>
<given-names>C.</given-names>
</name>
<name><surname>Frye</surname>
<given-names>R.A.</given-names>
</name>
<name><surname>Lifke</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ferel</surname>
<given-names>D.</given-names>
</name>
<name><surname>Wölfel</surname>
<given-names>C.</given-names>
</name>
<name><surname>Huber</surname>
<given-names>C.</given-names>
</name>
<name><surname>Wölfel</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>The response of autologous T cells to a human melanoma is dominated by mutated neoantigens</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2005</year>
<volume>102</volume>
<fpage>16013</fpage>
<lpage>16018</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0500090102</pub-id>
<pub-id pub-id-type="pmid">16247014</pub-id>
</element-citation>
</ref>
<ref id="B10-pharmaceutics-12-00153"><label>10.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baurain</surname>
<given-names>J.F.</given-names>
</name>
<name><surname>Colau</surname>
<given-names>D.</given-names>
</name>
<name><surname>van Baren</surname>
<given-names>N.</given-names>
</name>
<name><surname>Landry</surname>
<given-names>C.</given-names>
</name>
<name><surname>Martelange</surname>
<given-names>V.</given-names>
</name>
<name><surname>Vikkula</surname>
<given-names>M.</given-names>
</name>
<name><surname>Boon</surname>
<given-names>T.</given-names>
</name>
<name><surname>Coulie</surname>
<given-names>P.G.</given-names>
</name>
</person-group>
<article-title>High frequency of autologous anti-melanoma CTL directed against an antigen generated by a point mutation in a new helicase gene</article-title>
<source>J. Immunol.</source>
<year>2000</year>
<volume>164</volume>
<fpage>6057</fpage>
<lpage>6066</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.164.11.6057</pub-id>
<pub-id pub-id-type="pmid">10820291</pub-id>
</element-citation>
</ref>
<ref id="B11-pharmaceutics-12-00153"><label>11.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salmon</surname>
<given-names>H.</given-names>
</name>
<name><surname>Idoyaga</surname>
<given-names>J.</given-names>
</name>
<name><surname>Rahman</surname>
<given-names>A.</given-names>
</name>
<name><surname>Leboeuf</surname>
<given-names>M.</given-names>
</name>
<name><surname>Remark</surname>
<given-names>R.</given-names>
</name>
<name><surname>Jordan</surname>
<given-names>S.</given-names>
</name>
<name><surname>Casanova-Acebes</surname>
<given-names>M.</given-names>
</name>
<name><surname>Khudoynazarova</surname>
<given-names>M.</given-names>
</name>
<name><surname>Agudo</surname>
<given-names>J.</given-names>
</name>
<name><surname>Tung</surname>
<given-names>N.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition</article-title>
<source>Immunity</source>
<year>2016</year>
<volume>44</volume>
<fpage>924</fpage>
<lpage>938</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2016.03.012</pub-id>
<pub-id pub-id-type="pmid">27096321</pub-id>
</element-citation>
</ref>
<ref id="B12-pharmaceutics-12-00153"><label>12.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Spranger</surname>
<given-names>S.</given-names>
</name>
<name><surname>Dai</surname>
<given-names>D.</given-names>
</name>
<name><surname>Horton</surname>
<given-names>B.</given-names>
</name>
<name><surname>Gajewski</surname>
<given-names>T.F.</given-names>
</name>
</person-group>
<article-title>Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy</article-title>
<source>Cancer Cell</source>
<year>2017</year>
<volume>31</volume>
<fpage>711</fpage>
<lpage>723</lpage>
<pub-id pub-id-type="doi">10.1016/j.ccell.2017.04.003</pub-id>
<pub-id pub-id-type="pmid">28486109</pub-id>
</element-citation>
</ref>
<ref id="B13-pharmaceutics-12-00153"><label>13.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Broz</surname>
<given-names>M.L.</given-names>
</name>
<name><surname>Binnewies</surname>
<given-names>M.</given-names>
</name>
<name><surname>Boldajipour</surname>
<given-names>B.</given-names>
</name>
<name><surname>Nelson</surname>
<given-names>A.E.</given-names>
</name>
<name><surname>Pollack</surname>
<given-names>J.L.</given-names>
</name>
<name><surname>Erle</surname>
<given-names>D.J.</given-names>
</name>
<name><surname>Barczak</surname>
<given-names>A.</given-names>
</name>
<name><surname>Rosenblum</surname>
<given-names>M.D.</given-names>
</name>
<name><surname>Daud</surname>
<given-names>A.</given-names>
</name>
<name><surname>Barber</surname>
<given-names>D.L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity</article-title>
<source>Cancer Cell</source>
<year>2014</year>
<volume>26</volume>
<fpage>638</fpage>
<lpage>652</lpage>
<pub-id pub-id-type="doi">10.1016/j.ccell.2014.09.007</pub-id>
<pub-id pub-id-type="pmid">25446897</pub-id>
</element-citation>
</ref>
<ref id="B14-pharmaceutics-12-00153"><label>14.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hampton</surname>
<given-names>R.Y.</given-names>
</name>
</person-group>
<article-title>ER-associated degradation in protein quality control and cellular regulation</article-title>
<source>Curr. Opin. Cell Biol.</source>
<year>2002</year>
<volume>14</volume>
<fpage>476</fpage>
<lpage>482</lpage>
<pub-id pub-id-type="doi">10.1016/S0955-0674(02)00358-7</pub-id>
<pub-id pub-id-type="pmid">12383799</pub-id>
</element-citation>
</ref>
<ref id="B15-pharmaceutics-12-00153"><label>15.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsai</surname>
<given-names>B.</given-names>
</name>
<name><surname>Ye</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Rapoport</surname>
<given-names>T.A.</given-names>
</name>
</person-group>
<article-title>Retro-translocation of proteins from the endoplasmic reticulum into the cytosol</article-title>
<source>Nat. Rev. Mol. Cell Biol.</source>
<year>2002</year>
<volume>3</volume>
<fpage>246</fpage>
<lpage>255</lpage>
<pub-id pub-id-type="doi">10.1038/nrm780</pub-id>
<pub-id pub-id-type="pmid">11994744</pub-id>
</element-citation>
</ref>
<ref id="B16-pharmaceutics-12-00153"><label>16.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Preston</surname>
<given-names>G.M.</given-names>
</name>
<name><surname>Brodsky</surname>
<given-names>J.L.</given-names>
</name>
</person-group>
<article-title>The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation</article-title>
<source>Biochem. J.</source>
<year>2017</year>
<volume>474</volume>
<fpage>445</fpage>
<lpage>469</lpage>
<pub-id pub-id-type="doi">10.1042/BCJ20160582</pub-id>
<pub-id pub-id-type="pmid">28159894</pub-id>
</element-citation>
</ref>
<ref id="B17-pharmaceutics-12-00153"><label>17.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tamura</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Hirohashi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Kutomi</surname>
<given-names>G.</given-names>
</name>
<name><surname>Nakanishi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kamiguchi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Torigoe</surname>
<given-names>T.</given-names>
</name>
<name><surname>Sato</surname>
<given-names>N.</given-names>
</name>
</person-group>
<article-title>Tumor-produced secreted form of binding of immunoglobulin protein elicits antigen-specific tumor immunity</article-title>
<source>J. Immunol.</source>
<year>2011</year>
<volume>186</volume>
<fpage>4325</fpage>
<lpage>4330</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.1004048</pub-id>
<pub-id pub-id-type="pmid">21339366</pub-id>
</element-citation>
</ref>
<ref id="B18-pharmaceutics-12-00153"><label>18.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Basu</surname>
<given-names>S.</given-names>
</name>
<name><surname>Srivastava</surname>
<given-names>P.K.</given-names>
</name>
</person-group>
<article-title>Heat shock proteins: The fountainhead of innate and adaptive immune responses</article-title>
<source>Cell Stress Chaperones</source>
<year>2000</year>
<volume>5</volume>
<fpage>443</fpage>
<lpage>451</lpage>
<pub-id pub-id-type="doi">10.1379/1466-1268(2000)005<0443:HSPTFO>2.0.CO;2</pub-id>
<pub-id pub-id-type="pmid">11189450</pub-id>
</element-citation>
</ref>
<ref id="B19-pharmaceutics-12-00153"><label>19.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Srivastava</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Roles of heat-shock proteins in innate and adaptive immunity</article-title>
<source>Nat. Rev. Immunol.</source>
<year>2002</year>
<volume>3</volume>
<fpage>185</fpage>
<lpage>194</lpage>
<pub-id pub-id-type="doi">10.1038/nri749</pub-id>
</element-citation>
</ref>
<ref id="B20-pharmaceutics-12-00153"><label>20.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Constantino</surname>
<given-names>J.</given-names>
</name>
<name><surname>Gomes</surname>
<given-names>C.</given-names>
</name>
<name><surname>Falcão</surname>
<given-names>A.</given-names>
</name>
<name><surname>Cruz</surname>
<given-names>M.T.</given-names>
</name>
<name><surname>Neves</surname>
<given-names>B.M.</given-names>
</name>
</person-group>
<article-title>Antitumor dendritic cell-based vaccines: Lessons from 20 years of clinical trials and future perspectives</article-title>
<source>Transl. Res.</source>
<year>2016</year>
<volume>168</volume>
<fpage>74</fpage>
<lpage>95</lpage>
<pub-id pub-id-type="doi">10.1016/j.trsl.2015.07.008</pub-id>
<pub-id pub-id-type="pmid">26297944</pub-id>
</element-citation>
</ref>
<ref id="B21-pharmaceutics-12-00153"><label>21.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hodi</surname>
<given-names>F.S.</given-names>
</name>
<name><surname>O’Day</surname>
<given-names>S.J.</given-names>
</name>
<name><surname>McDermott</surname>
<given-names>D.F.</given-names>
</name>
<name><surname>Weber</surname>
<given-names>R.W.</given-names>
</name>
<name><surname>Sosman</surname>
<given-names>J.A.</given-names>
</name>
<name><surname>Haanen</surname>
<given-names>J.B.</given-names>
</name>
<name><surname>Gonzalez</surname>
<given-names>R.</given-names>
</name>
<name><surname>Robert</surname>
<given-names>C.</given-names>
</name>
<name><surname>Schadendorf</surname>
<given-names>D.</given-names>
</name>
<name><surname>Hassel</surname>
<given-names>J.C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Improved survival with ipilimumab in patients with metastatic melanoma</article-title>
<source>N. Engl. J. Med.</source>
<year>2010</year>
<volume>363</volume>
<fpage>711</fpage>
<lpage>723</lpage>
<pub-id pub-id-type="doi">10.1056/NEJMoa1003466</pub-id>
<pub-id pub-id-type="pmid">20525992</pub-id>
</element-citation>
</ref>
<ref id="B22-pharmaceutics-12-00153"><label>22.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heery</surname>
<given-names>C.R.</given-names>
</name>
<name><surname>O’Sullivan-Coyne</surname>
<given-names>G.</given-names>
</name>
<name><surname>Madan</surname>
<given-names>R.A.</given-names>
</name>
<name><surname>Cordes</surname>
<given-names>L.</given-names>
</name>
<name><surname>Rajan</surname>
<given-names>A.</given-names>
</name>
<name><surname>Rauckhorst</surname>
<given-names>M.</given-names>
</name>
<name><surname>Lamping</surname>
<given-names>E.</given-names>
</name>
<name><surname>Oyelakin</surname>
<given-names>I.</given-names>
</name>
<name><surname>Marté</surname>
<given-names>J.L.</given-names>
</name>
<name><surname>Lepone</surname>
<given-names>L.M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): A phase 1a, multicohort, dose-escalation trial</article-title>
<source>Lancet Oncol.</source>
<year>2017</year>
<volume>18</volume>
<fpage>587</fpage>
<lpage>598</lpage>
<pub-id pub-id-type="doi">10.1016/S1470-2045(17)30239-5</pub-id>
<pub-id pub-id-type="pmid">28373007</pub-id>
</element-citation>
</ref>
<ref id="B23-pharmaceutics-12-00153"><label>23.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Syn</surname>
<given-names>N.L.</given-names>
</name>
<name><surname>Teng</surname>
<given-names>M.W.L.</given-names>
</name>
<name><surname>Mok</surname>
<given-names>T.S.K.</given-names>
</name>
<name><surname>Soo</surname>
<given-names>R.A.</given-names>
</name>
</person-group>
<article-title>De-novo and acquired resistance to immune checkpoint targeting</article-title>
<source>Lancet Oncol.</source>
<year>2017</year>
<volume>18</volume>
<fpage>e731</fpage>
<lpage>e741</lpage>
<pub-id pub-id-type="doi">10.1016/S1470-2045(17)30607-1</pub-id>
<pub-id pub-id-type="pmid">29208439</pub-id>
</element-citation>
</ref>
<ref id="B24-pharmaceutics-12-00153"><label>24.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Topalian</surname>
<given-names>S.L.</given-names>
</name>
<name><surname>Hodi</surname>
<given-names>F.S.</given-names>
</name>
<name><surname>Brahmer</surname>
<given-names>J.R.</given-names>
</name>
<name><surname>Gettinger</surname>
<given-names>S.N.</given-names>
</name>
<name><surname>Smith</surname>
<given-names>D.C.</given-names>
</name>
<name><surname>McDermott</surname>
<given-names>D.F.</given-names>
</name>
<name><surname>Powderly</surname>
<given-names>J.D.</given-names>
</name>
<name><surname>Carvajal</surname>
<given-names>R.D.</given-names>
</name>
<name><surname>Sosman</surname>
<given-names>J.A.</given-names>
</name>
<name><surname>Atkins</surname>
<given-names>M.B.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer</article-title>
<source>N. Engl. J. Med.</source>
<year>2012</year>
<volume>366</volume>
<fpage>2443</fpage>
<lpage>2454</lpage>
<pub-id pub-id-type="doi">10.1056/NEJMoa1200690</pub-id>
<pub-id pub-id-type="pmid">22658127</pub-id>
</element-citation>
</ref>
<ref id="B25-pharmaceutics-12-00153"><label>25.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garris</surname>
<given-names>C.S.</given-names>
</name>
<name><surname>Arlauckas</surname>
<given-names>S.P.</given-names>
</name>
<name><surname>Kohler</surname>
<given-names>R.H.</given-names>
</name>
<name><surname>Trefny</surname>
<given-names>M.P.</given-names>
</name>
<name><surname>Garren</surname>
<given-names>S.</given-names>
</name>
<name><surname>Piot</surname>
<given-names>C.</given-names>
</name>
<name><surname>Engblom</surname>
<given-names>C.</given-names>
</name>
<name><surname>Pfirschke</surname>
<given-names>C.</given-names>
</name>
<name><surname>Siwicki</surname>
<given-names>M.</given-names>
</name>
<name><surname>Gungabeesoon</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-gamma and IL-12</article-title>
<source>Immunity</source>
<year>2018</year>
<volume>49</volume>
<fpage>1148</fpage>
<lpage>1161</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2018.09.024</pub-id>
<pub-id pub-id-type="pmid">30552023</pub-id>
</element-citation>
</ref>
<ref id="B26-pharmaceutics-12-00153"><label>26.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kreutz</surname>
<given-names>M.</given-names>
</name>
<name><surname>Tacken</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>Figdor</surname>
<given-names>C.G.</given-names>
</name>
</person-group>
<article-title>Targeting dendritic cells—Why bother?</article-title>
<source>Blood</source>
<year>2013</year>
<volume>121</volume>
<fpage>2836</fpage>
<lpage>2844</lpage>
<pub-id pub-id-type="doi">10.1182/blood-2012-09-452078</pub-id>
<pub-id pub-id-type="pmid">23390195</pub-id>
</element-citation>
</ref>
<ref id="B27-pharmaceutics-12-00153"><label>27.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ofuji</surname>
<given-names>K.</given-names>
</name>
<name><surname>Tada</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Yoshikawa</surname>
<given-names>T.</given-names>
</name>
<name><surname>Shimomura</surname>
<given-names>M.</given-names>
</name>
<name><surname>Yoshimura</surname>
<given-names>M.</given-names>
</name>
<name><surname>Saito</surname>
<given-names>K.</given-names>
</name>
<name><surname>Nakamoto</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Nakatsura</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>A peptide antigen derived from EGFR T790M is immunogenic in non-small cell lung cancer</article-title>
<source>Int. J. Oncol.</source>
<year>2015</year>
<volume>46</volume>
<fpage>497</fpage>
<lpage>504</lpage>
<pub-id pub-id-type="pmid">25532027</pub-id>
</element-citation>
</ref>
<ref id="B28-pharmaceutics-12-00153"><label>28.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Teitz-Tennenbaum</surname>
<given-names>S.</given-names>
</name>
<name><surname>Li</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Rynkiewicz</surname>
<given-names>S.</given-names>
</name>
<name><surname>Ito</surname>
<given-names>F.</given-names>
</name>
<name><surname>Davis</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Mcginn</surname>
<given-names>C.J.</given-names>
</name>
<name><surname>Chang</surname>
<given-names>A.E.</given-names>
</name>
</person-group>
<article-title>Radiotherapy Potentiates the Therapeutic Efficacy of Intratumoral Dendritic Cell Administration</article-title>
<source>Cancer Res.</source>
<year>2003</year>
<volume>63</volume>
<fpage>8466</fpage>
<lpage>8475</lpage>
<pub-id pub-id-type="pmid">14679011</pub-id>
</element-citation>
</ref>
<ref id="B29-pharmaceutics-12-00153"><label>29.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Steinman</surname>
<given-names>R.M.</given-names>
</name>
</person-group>
<article-title>Decisions about dendritic cells: Past, present, and future</article-title>
<source>Annu. Rev. Immunol.</source>
<year>2011</year>
<volume>30</volume>
<fpage>1</fpage>
<lpage>22</lpage>
<pub-id pub-id-type="doi">10.1146/annurev-immunol-100311-102839</pub-id>
<pub-id pub-id-type="pmid">22136168</pub-id>
</element-citation>
</ref>
<ref id="B30-pharmaceutics-12-00153"><label>30.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schlitzer</surname>
<given-names>A.</given-names>
</name>
<name><surname>McGovern</surname>
<given-names>N.</given-names>
</name>
<name><surname>Ginhoux</surname>
<given-names>F.</given-names>
</name>
</person-group>
<article-title>Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems</article-title>
<source>Semin. Cell Dev. Biol.</source>
<year>2015</year>
<volume>41</volume>
<fpage>9</fpage>
<lpage>22</lpage>
<pub-id pub-id-type="doi">10.1016/j.semcdb.2015.03.011</pub-id>
<pub-id pub-id-type="pmid">25957517</pub-id>
</element-citation>
</ref>
<ref id="B31-pharmaceutics-12-00153"><label>31.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Collin</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bigley</surname>
<given-names>V.</given-names>
</name>
</person-group>
<article-title>Human dendritic cell subsets: An update</article-title>
<source>Immunology</source>
<year>2008</year>
<volume>154</volume>
<fpage>3</fpage>
<lpage>20</lpage>
<pub-id pub-id-type="doi">10.1111/imm.12888</pub-id>
<pub-id pub-id-type="pmid">29313948</pub-id>
</element-citation>
</ref>
<ref id="B32-pharmaceutics-12-00153"><label>32.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Merad</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sathe</surname>
<given-names>P.</given-names>
</name>
<name><surname>Helft</surname>
<given-names>J.</given-names>
</name>
<name><surname>Miller</surname>
<given-names>J.</given-names>
</name>
<name><surname>Mortha</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting</article-title>
<source>Annu. Rev. Immunol.</source>
<year>2013</year>
<volume>31</volume>
<fpage>563</fpage>
<lpage>604</lpage>
<pub-id pub-id-type="doi">10.1146/annurev-immunol-020711-074950</pub-id>
<pub-id pub-id-type="pmid">23516985</pub-id>
</element-citation>
</ref>
<ref id="B33-pharmaceutics-12-00153"><label>33.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Böttcher</surname>
<given-names>J.P.</given-names>
</name>
<name><surname>Reis Sousa</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>The role of type 1 conventional dendritic cells in cancer immunity</article-title>
<source>Trends Cancer</source>
<year>2018</year>
<volume>4</volume>
<fpage>784</fpage>
<lpage>792</lpage>
<pub-id pub-id-type="doi">10.1016/j.trecan.2018.09.001</pub-id>
<pub-id pub-id-type="pmid">30352680</pub-id>
</element-citation>
</ref>
<ref id="B34-pharmaceutics-12-00153"><label>34.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Demoulin</surname>
<given-names>S.</given-names>
</name>
<name><surname>Herfs</surname>
<given-names>M.</given-names>
</name>
<name><surname>Delvenne</surname>
<given-names>P.</given-names>
</name>
<name><surname>Hubert</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: Insight into the molecular mechanisms</article-title>
<source>J. Leukoc. Biol.</source>
<year>2013</year>
<volume>93</volume>
<fpage>343</fpage>
<lpage>352</lpage>
<pub-id pub-id-type="doi">10.1189/jlb.0812397</pub-id>
<pub-id pub-id-type="pmid">23136258</pub-id>
</element-citation>
</ref>
<ref id="B35-pharmaceutics-12-00153"><label>35.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guilliams</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ginhoux</surname>
<given-names>F.</given-names>
</name>
<name><surname>Jakubzick</surname>
<given-names>C.</given-names>
</name>
<name><surname>Naik</surname>
<given-names>S.H.</given-names>
</name>
<name><surname>Onai</surname>
<given-names>N.</given-names>
</name>
<name><surname>Schraml</surname>
<given-names>B.U.</given-names>
</name>
<name><surname>Segura</surname>
<given-names>E.</given-names>
</name>
<name><surname>Tussiwand</surname>
<given-names>R.</given-names>
</name>
<name><surname>Yona</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Dendritic cells, monocytes and macrophages: A unified nomenclature based on ontogeny</article-title>
<source>Nat. Rev. Immunol.</source>
<year>2014</year>
<volume>14</volume>
<fpage>571</fpage>
<lpage>578</lpage>
<pub-id pub-id-type="doi">10.1038/nri3712</pub-id>
<pub-id pub-id-type="pmid">25033907</pub-id>
</element-citation>
</ref>
<ref id="B36-pharmaceutics-12-00153"><label>36.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Segura</surname>
<given-names>E.</given-names>
</name>
<name><surname>Albiston</surname>
<given-names>A.L.</given-names>
</name>
<name><surname>Wicks</surname>
<given-names>I.P.</given-names>
</name>
<name><surname>Chai</surname>
<given-names>S.Y.</given-names>
</name>
<name><surname>Villadangos</surname>
<given-names>J.A.</given-names>
</name>
</person-group>
<article-title>Different cross-presentation pathways in steady-state and inflammatory dendritic cells</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2009</year>
<volume>106</volume>
<fpage>20377</fpage>
<lpage>20381</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0910295106</pub-id>
<pub-id pub-id-type="pmid">19918052</pub-id>
</element-citation>
</ref>
<ref id="B37-pharmaceutics-12-00153"><label>37.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Villani</surname>
<given-names>A.C.</given-names>
</name>
<name><surname>Satija</surname>
<given-names>R.</given-names>
</name>
<name><surname>Reynolds</surname>
<given-names>G.</given-names>
</name>
<name><surname>Sarkizova</surname>
<given-names>S.</given-names>
</name>
<name><surname>Shekhar</surname>
<given-names>K.</given-names>
</name>
<name><surname>Fletcher</surname>
<given-names>J.</given-names>
</name>
<name><surname>Griesbeck</surname>
<given-names>M.</given-names>
</name>
<name><surname>Butler</surname>
<given-names>A.</given-names>
</name>
<name><surname>Zheng</surname>
<given-names>S.</given-names>
</name>
<name><surname>Lazo</surname>
<given-names>S.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors</article-title>
<source>Science</source>
<year>2017</year>
<volume>356</volume>
<fpage>eaah4573</fpage>
<pub-id pub-id-type="doi">10.1126/science.aah4573</pub-id>
<pub-id pub-id-type="pmid">28428369</pub-id>
</element-citation>
</ref>
<ref id="B38-pharmaceutics-12-00153"><label>38.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kamphorst</surname>
<given-names>A.O.</given-names>
</name>
<name><surname>Guermonprez</surname>
<given-names>P.</given-names>
</name>
<name><surname>Dudziak</surname>
<given-names>D.</given-names>
</name>
<name><surname>Nussenzweig</surname>
<given-names>M.C.</given-names>
</name>
</person-group>
<article-title>Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes</article-title>
<source>J. Immunol.</source>
<year>2010</year>
<volume>185</volume>
<fpage>3426</fpage>
<lpage>3435</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.1001205</pub-id>
<pub-id pub-id-type="pmid">20729332</pub-id>
</element-citation>
</ref>
<ref id="B39-pharmaceutics-12-00153"><label>39.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eickhoff</surname>
<given-names>S.</given-names>
</name>
<name><surname>Brewitz</surname>
<given-names>A.</given-names>
</name>
<name><surname>Gerner</surname>
<given-names>M.Y.</given-names>
</name>
<name><surname>Klauschen</surname>
<given-names>F.</given-names>
</name>
<name><surname>Komander</surname>
<given-names>K.</given-names>
</name>
<name><surname>Hemmi</surname>
<given-names>H.</given-names>
</name>
<name><surname>Garbi</surname>
<given-names>N.</given-names>
</name>
<name><surname>Kaisho</surname>
<given-names>T.</given-names>
</name>
<name><surname>Germain</surname>
<given-names>R.N.</given-names>
</name>
<name><surname>Kastenmüller</surname>
<given-names>W.</given-names>
</name>
</person-group>
<article-title>Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions</article-title>
<source>Cell</source>
<year>2015</year>
<volume>162</volume>
<fpage>1322</fpage>
<lpage>1337</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2015.08.004</pub-id>
<pub-id pub-id-type="pmid">26296422</pub-id>
</element-citation>
</ref>
<ref id="B40-pharmaceutics-12-00153"><label>40.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hor</surname>
<given-names>J.L.</given-names>
</name>
<name><surname>Whitney</surname>
<given-names>P.G.</given-names>
</name>
<name><surname>Zaid</surname>
<given-names>A.</given-names>
</name>
<name><surname>Brooks</surname>
<given-names>A.G.</given-names>
</name>
<name><surname>Heath</surname>
<given-names>W.R.</given-names>
</name>
<name><surname>Mueller</surname>
<given-names>S.N.</given-names>
</name>
</person-group>
<article-title>Spatiotemporally distinct interactions with dendritic cell subsets facilitates CD4+ and CD8+ T cell activation to localized viral infection</article-title>
<source>Immunity</source>
<year>2015</year>
<volume>43</volume>
<fpage>554</fpage>
<lpage>565</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2015.07.020</pub-id>
<pub-id pub-id-type="pmid">26297566</pub-id>
</element-citation>
</ref>
<ref id="B41-pharmaceutics-12-00153"><label>41.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sun</surname>
<given-names>J.C.</given-names>
</name>
<name><surname>Williams</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Bevan</surname>
<given-names>M.J.</given-names>
</name>
</person-group>
<article-title>CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection</article-title>
<source>Nat. Immunol.</source>
<year>2004</year>
<volume>5</volume>
<fpage>927</fpage>
<lpage>933</lpage>
<pub-id pub-id-type="doi">10.1038/ni1105</pub-id>
<pub-id pub-id-type="pmid">15300249</pub-id>
</element-citation>
</ref>
<ref id="B42-pharmaceutics-12-00153"><label>42.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hochrein</surname>
<given-names>H.</given-names>
</name>
<name><surname>Shortman</surname>
<given-names>K.</given-names>
</name>
<name><surname>Vremec</surname>
<given-names>D.</given-names>
</name>
<name><surname>Scott</surname>
<given-names>B.</given-names>
</name>
<name><surname>Hertzog</surname>
<given-names>P.</given-names>
</name>
<name><surname>O’Keeffe</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets</article-title>
<source>J. Immunol.</source>
<year>2001</year>
<volume>166</volume>
<fpage>5448</fpage>
<lpage>5455</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.166.9.5448</pub-id>
<pub-id pub-id-type="pmid">11313382</pub-id>
</element-citation>
</ref>
<ref id="B43-pharmaceutics-12-00153"><label>43.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mashayekhi</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sandau</surname>
<given-names>M.M.</given-names>
</name>
<name><surname>Dunay</surname>
<given-names>I.R.</given-names>
</name>
<name><surname>Frickel</surname>
<given-names>E.M.</given-names>
</name>
<name><surname>Khan</surname>
<given-names>A.</given-names>
</name>
<name><surname>Goldszmid</surname>
<given-names>R.S.</given-names>
</name>
<name><surname>Sher</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ploegh</surname>
<given-names>H.L.</given-names>
</name>
<name><surname>Murphy</surname>
<given-names>T.L.</given-names>
</name>
<name><surname>Sibley</surname>
<given-names>L.D.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>CD8alpha(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by <italic>Toxoplasma gondii</italic>
tachyzoites</article-title>
<source>Immunity</source>
<year>2011</year>
<volume>35</volume>
<fpage>249</fpage>
<lpage>259</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2011.08.008</pub-id>
<pub-id pub-id-type="pmid">21867928</pub-id>
</element-citation>
</ref>
<ref id="B44-pharmaceutics-12-00153"><label>44.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dudziak</surname>
<given-names>D.</given-names>
</name>
<name><surname>Kamphorst</surname>
<given-names>A.O.</given-names>
</name>
<name><surname>Heidkamp</surname>
<given-names>G.F.</given-names>
</name>
<name><surname>Buchholz</surname>
<given-names>V.R.</given-names>
</name>
<name><surname>Trumpfheller</surname>
<given-names>C.</given-names>
</name>
<name><surname>Yamazaki</surname>
<given-names>S.</given-names>
</name>
<name><surname>Cheong</surname>
<given-names>C.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>K.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>H.W.</given-names>
</name>
<name><surname>Park</surname>
<given-names>C.G.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Differential antigen processing by dendritic cell subsets in vivo</article-title>
<source>Science</source>
<year>2007</year>
<volume>315</volume>
<fpage>107</fpage>
<lpage>111</lpage>
<pub-id pub-id-type="doi">10.1126/science.1136080</pub-id>
<pub-id pub-id-type="pmid">17204652</pub-id>
</element-citation>
</ref>
<ref id="B45-pharmaceutics-12-00153"><label>45.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sánchez-Paulete</surname>
<given-names>A.R.</given-names>
</name>
<name><surname>Cueto</surname>
<given-names>F.J.</given-names>
</name>
<name><surname>Martínez-López</surname>
<given-names>M.</given-names>
</name>
<name><surname>Labiano</surname>
<given-names>S.</given-names>
</name>
<name><surname>Morales-Kastresana</surname>
<given-names>A.</given-names>
</name>
<name><surname>Rodríguez-Ruiz</surname>
<given-names>M.E.</given-names>
</name>
<name><surname>Jure-Kunkel</surname>
<given-names>M.</given-names>
</name>
<name><surname>Azpilikueta</surname>
<given-names>A.</given-names>
</name>
<name><surname>Aznar</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Quetglas</surname>
<given-names>J.I.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells</article-title>
<source>Cancer Discov.</source>
<year>2016</year>
<volume>6</volume>
<fpage>71</fpage>
<lpage>79</lpage>
<pub-id pub-id-type="doi">10.1158/2159-8290.CD-15-0510</pub-id>
<pub-id pub-id-type="pmid">26493961</pub-id>
</element-citation>
</ref>
<ref id="B46-pharmaceutics-12-00153"><label>46.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barry</surname>
<given-names>K.C.</given-names>
</name>
<name><surname>Hsu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Broz</surname>
<given-names>M.L.</given-names>
</name>
<name><surname>Cueto</surname>
<given-names>F.J.</given-names>
</name>
<name><surname>Binnewies</surname>
<given-names>M.</given-names>
</name>
<name><surname>Combes</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Nelson</surname>
<given-names>A.E.</given-names>
</name>
<name><surname>Loo</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kumar</surname>
<given-names>R.</given-names>
</name>
<name><surname>Rosenblum</surname>
<given-names>M.D.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments</article-title>
<source>Nat. Med.</source>
<year>2018</year>
<volume>24</volume>
<fpage>1</fpage>
<lpage>14</lpage>
<pub-id pub-id-type="doi">10.1038/s41591-018-0085-8</pub-id>
<pub-id pub-id-type="pmid">29315299</pub-id>
</element-citation>
</ref>
<ref id="B47-pharmaceutics-12-00153"><label>47.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chiang</surname>
<given-names>M.C.</given-names>
</name>
<name><surname>Chiang</surname>
<given-names>M.C.</given-names>
</name>
<name><surname>Tullett</surname>
<given-names>K.M.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>Y.S.</given-names>
</name>
<name><surname>Idris</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ding</surname>
<given-names>Y.</given-names>
</name>
<name><surname>McDonald</surname>
<given-names>K.J.</given-names>
</name>
<name><surname>Kassianos</surname>
<given-names>A.</given-names>
</name>
<name><surname>Leal Rojas</surname>
<given-names>I.M.</given-names>
</name>
<name><surname>Jeet</surname>
<given-names>V.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Differential uptake and cross- presentation of soluble and necrotic cell antigen by human DC subsets</article-title>
<source>Eur. J. Immunol.</source>
<year>2016</year>
<volume>46</volume>
<fpage>329</fpage>
<lpage>339</lpage>
<pub-id pub-id-type="doi">10.1002/eji.201546023</pub-id>
<pub-id pub-id-type="pmid">26542182</pub-id>
</element-citation>
</ref>
<ref id="B48-pharmaceutics-12-00153"><label>48.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sittig</surname>
<given-names>S.P.</given-names>
</name>
<name><surname>Bakdash</surname>
<given-names>G.</given-names>
</name>
<name><surname>Weiden</surname>
<given-names>J.</given-names>
</name>
<name><surname>Sköld</surname>
<given-names>A.E.</given-names>
</name>
<name><surname>Tel</surname>
<given-names>J.</given-names>
</name>
<name><surname>Figdor</surname>
<given-names>C.G.</given-names>
</name>
<name><surname>de Vries</surname>
<given-names>I.J.</given-names>
</name>
<name><surname>Schreibelt</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>A comparative study of the T cell stimulatory and polarizing capacity of human primary blood dendritic cell subsets</article-title>
<source>Mediat. Inflamm.</source>
<year>2016</year>
<volume>2016</volume>
<fpage>3605643</fpage>
<pub-id pub-id-type="doi">10.1155/2016/3605643</pub-id>
</element-citation>
</ref>
<ref id="B49-pharmaceutics-12-00153"><label>49.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Segura</surname>
<given-names>E.</given-names>
</name>
<name><surname>Durand</surname>
<given-names>M.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells</article-title>
<source>J. Exp. Med.</source>
<year>2013</year>
<volume>210</volume>
<fpage>1035</fpage>
<lpage>1047</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20121103</pub-id>
<pub-id pub-id-type="pmid">23569327</pub-id>
</element-citation>
</ref>
<ref id="B50-pharmaceutics-12-00153"><label>50.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yin</surname>
<given-names>X.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>H.</given-names>
</name>
<name><surname>Jin</surname>
<given-names>X.</given-names>
</name>
<name><surname>Li</surname>
<given-names>J.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>H.</given-names>
</name>
<name><surname>Shi</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Yin</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>X.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Human blood CD1c+ dendritic cells encompass CD5high and CD5low subsets that differ significantly in phenotype, gene expression, and functions</article-title>
<source>J. Immunol.</source>
<year>2017</year>
<volume>198</volume>
<fpage>1553</fpage>
<lpage>1564</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.1600193</pub-id>
<pub-id pub-id-type="pmid">28087664</pub-id>
</element-citation>
</ref>
<ref id="B51-pharmaceutics-12-00153"><label>51.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mitchell</surname>
<given-names>D.</given-names>
</name>
<name><surname>Chintala</surname>
<given-names>S.</given-names>
</name>
<name><surname>Dey</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Plasmacytoid dendritic cell in immunity and cancer</article-title>
<source>J. Neuroimmunol.</source>
<year>2018</year>
<volume>322</volume>
<fpage>63</fpage>
<lpage>73</lpage>
<pub-id pub-id-type="doi">10.1016/j.jneuroim.2018.06.012</pub-id>
<pub-id pub-id-type="pmid">30049538</pub-id>
</element-citation>
</ref>
<ref id="B52-pharmaceutics-12-00153"><label>52.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Di Pucchio</surname>
<given-names>T.</given-names>
</name>
<name><surname>Chatterjee</surname>
<given-names>B.</given-names>
</name>
<name><surname>Smed-Sörensen</surname>
<given-names>A.</given-names>
</name>
<name><surname>Clayton</surname>
<given-names>S.</given-names>
</name>
<name><surname>Palazzo</surname>
<given-names>A.</given-names>
</name>
<name><surname>Montes</surname>
<given-names>M.</given-names>
</name>
<name><surname>Xue</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Mellman</surname>
<given-names>I.</given-names>
</name>
<name><surname>Banchereau</surname>
<given-names>J.</given-names>
</name>
<name><surname>Connolly</surname>
<given-names>J.E.</given-names>
</name>
</person-group>
<article-title>Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I</article-title>
<source>Nat. Immunol.</source>
<year>2008</year>
<volume>9</volume>
<fpage>551</fpage>
<lpage>557</lpage>
<pub-id pub-id-type="doi">10.1038/ni.1602</pub-id>
<pub-id pub-id-type="pmid">18376401</pub-id>
</element-citation>
</ref>
<ref id="B53-pharmaceutics-12-00153"><label>53.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leon</surname>
<given-names>B.</given-names>
</name>
<name><surname>Martinez del Hoyo</surname>
<given-names>G.</given-names>
</name>
<name><surname>Parrillas</surname>
<given-names>V.</given-names>
</name>
<name><surname>Vargas</surname>
<given-names>H.H.</given-names>
</name>
<name><surname>Sanchez-Mateos</surname>
<given-names>P.</given-names>
</name>
<name><surname>Longo</surname>
<given-names>N.</given-names>
</name>
<name><surname>Lopez-Bravo</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ardavin</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>Dendritic cell differentiation potential of mouse monocytes: Monocytes represent immediate precursors of CD8- and CD8+ splenic dendritic cells</article-title>
<source>Blood</source>
<year>2004</year>
<volume>103</volume>
<fpage>2668</fpage>
<lpage>2676</lpage>
<pub-id pub-id-type="doi">10.1182/blood-2003-01-0286</pub-id>
<pub-id pub-id-type="pmid">14630812</pub-id>
</element-citation>
</ref>
<ref id="B54-pharmaceutics-12-00153"><label>54.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Auffray</surname>
<given-names>C.</given-names>
</name>
<name><surname>Fogg</surname>
<given-names>D.K.</given-names>
</name>
<name><surname>Narni-Mancinelli</surname>
<given-names>E.</given-names>
</name>
<name><surname>Senechal</surname>
<given-names>B.</given-names>
</name>
<name><surname>Trouillet</surname>
<given-names>C.</given-names>
</name>
<name><surname>Saederup</surname>
<given-names>N.</given-names>
</name>
<name><surname>Leemput</surname>
<given-names>J.</given-names>
</name>
<name><surname>Bigot</surname>
<given-names>K.</given-names>
</name>
<name><surname>Campisi</surname>
<given-names>L.</given-names>
</name>
<name><surname>Abitbol</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation</article-title>
<source>J. Exp. Med.</source>
<year>2009</year>
<volume>206</volume>
<fpage>595</fpage>
<lpage>606</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20081385</pub-id>
<pub-id pub-id-type="pmid">19273628</pub-id>
</element-citation>
</ref>
<ref id="B55-pharmaceutics-12-00153"><label>55.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Segura</surname>
<given-names>E.</given-names>
</name>
<name><surname>Touzot</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bohineust</surname>
<given-names>A.</given-names>
</name>
<name><surname>Cappuccio</surname>
<given-names>A.</given-names>
</name>
<name><surname>Chiocchia</surname>
<given-names>G.</given-names>
</name>
<name><surname>Hosmalin</surname>
<given-names>A.</given-names>
</name>
<name><surname>Dalod</surname>
<given-names>M.</given-names>
</name>
<name><surname>Soumelis</surname>
<given-names>V.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Human inflammatory dendritic cells induce Th17 cell differentiation</article-title>
<source>Immunity</source>
<year>2013</year>
<volume>38</volume>
<fpage>336</fpage>
<lpage>348</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2012.10.018</pub-id>
<pub-id pub-id-type="pmid">23352235</pub-id>
</element-citation>
</ref>
<ref id="B56-pharmaceutics-12-00153"><label>56.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shortman</surname>
<given-names>K.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.J.</given-names>
</name>
</person-group>
<article-title>Mouse and human dendritic cell subtypes</article-title>
<source>Nat. Rev. Immunol.</source>
<year>2002</year>
<volume>2</volume>
<fpage>151</fpage>
<lpage>161</lpage>
<pub-id pub-id-type="doi">10.1038/nri746</pub-id>
<pub-id pub-id-type="pmid">11913066</pub-id>
</element-citation>
</ref>
<ref id="B57-pharmaceutics-12-00153"><label>57.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheong</surname>
<given-names>C.</given-names>
</name>
<name><surname>Matos</surname>
<given-names>I.</given-names>
</name>
<name><surname>Choi</surname>
<given-names>J.H.</given-names>
</name>
<name><surname>Dandamudi</surname>
<given-names>D.B.</given-names>
</name>
<name><surname>Shrestha</surname>
<given-names>E.</given-names>
</name>
<name><surname>Longhi</surname>
<given-names>M.P.</given-names>
</name>
<name><surname>Jeffrey</surname>
<given-names>K.L.</given-names>
</name>
<name><surname>Anthony</surname>
<given-names>R.M.</given-names>
</name>
<name><surname>Kluger</surname>
<given-names>C.</given-names>
</name>
<name><surname>Nchinda</surname>
<given-names>G.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas</article-title>
<source>Cell</source>
<year>2010</year>
<volume>143</volume>
<fpage>416</fpage>
<lpage>429</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2010.09.039</pub-id>
<pub-id pub-id-type="pmid">21029863</pub-id>
</element-citation>
</ref>
<ref id="B58-pharmaceutics-12-00153"><label>58.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Markov</surname>
<given-names>O.V.</given-names>
</name>
<name><surname>Mironova</surname>
<given-names>N.L.</given-names>
</name>
<name><surname>Vlasov</surname>
<given-names>V.V.</given-names>
</name>
<name><surname>Zenkova</surname>
<given-names>M.A.</given-names>
</name>
</person-group>
<article-title>Molecular and Cellular Mechanisms of Antitumor Immune Response Activation by Dendritic Cells</article-title>
<source>Acta Nat.</source>
<year>2016</year>
<volume>8</volume>
<fpage>17</fpage>
<lpage>30</lpage>
<pub-id pub-id-type="doi">10.32607/20758251-2016-8-3-17-30</pub-id>
</element-citation>
</ref>
<ref id="B59-pharmaceutics-12-00153"><label>59.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Medel</surname>
<given-names>B.</given-names>
</name>
<name><surname>Costoya</surname>
<given-names>C.</given-names>
</name>
<name><surname>Fernandez</surname>
<given-names>D.</given-names>
</name>
<name><surname>Pereda</surname>
<given-names>C.</given-names>
</name>
<name><surname>Lladser</surname>
<given-names>A.</given-names>
</name>
<name><surname>Sauma</surname>
<given-names>D.</given-names>
</name>
<name><surname>Pacheco</surname>
<given-names>R.</given-names>
</name>
<name><surname>Iwawaki</surname>
<given-names>T.</given-names>
</name>
<name><surname>Salazar-Onfray</surname>
<given-names>F.</given-names>
</name>
<name><surname>Osorio</surname>
<given-names>F.</given-names>
</name>
</person-group>
<article-title>IRE1alpha Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming</article-title>
<source>Front. Immunol.</source>
<year>2018</year>
<volume>9</volume>
<fpage>3050</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2018.03050</pub-id>
<pub-id pub-id-type="pmid">30687308</pub-id>
</element-citation>
</ref>
<ref id="B60-pharmaceutics-12-00153"><label>60.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Plantinga</surname>
<given-names>M.</given-names>
</name>
<name><surname>Guilliams</surname>
<given-names>M.</given-names>
</name>
<name><surname>Vanheerswynghels</surname>
<given-names>M.</given-names>
</name>
<name><surname>Deswarte</surname>
<given-names>K.</given-names>
</name>
<name><surname>Branco-Madeira</surname>
<given-names>F.</given-names>
</name>
<name><surname>Toussaint</surname>
<given-names>W.</given-names>
</name>
<name><surname>Vanhoutte</surname>
<given-names>L.</given-names>
</name>
<name><surname>Neyt</surname>
<given-names>K.</given-names>
</name>
<name><surname>Killeen</surname>
<given-names>N.</given-names>
</name>
<name><surname>Malissen</surname>
<given-names>B.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen</article-title>
<source>Immunity</source>
<year>2013</year>
<volume>38</volume>
<fpage>322</fpage>
<lpage>335</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2012.10.016</pub-id>
<pub-id pub-id-type="pmid">23352232</pub-id>
</element-citation>
</ref>
<ref id="B61-pharmaceutics-12-00153"><label>61.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Briseno</surname>
<given-names>C.G.</given-names>
</name>
<name><surname>Haldar</surname>
<given-names>M.</given-names>
</name>
<name><surname>Kretzer</surname>
<given-names>N.M.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>X.</given-names>
</name>
<name><surname>Theisen</surname>
<given-names>D.J.</given-names>
</name>
<name><surname>Kc</surname>
<given-names>W.</given-names>
</name>
<name><surname>Durai</surname>
<given-names>V.</given-names>
</name>
<name><surname>Grajales-Reyes</surname>
<given-names>G.E.</given-names>
</name>
<name><surname>Iwata</surname>
<given-names>A.</given-names>
</name>
<name><surname>Bagadia</surname>
<given-names>P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells</article-title>
<source>Cell Rep.</source>
<year>2016</year>
<volume>15</volume>
<fpage>2462</fpage>
<lpage>2474</lpage>
<pub-id pub-id-type="doi">10.1016/j.celrep.2016.05.025</pub-id>
<pub-id pub-id-type="pmid">27264183</pub-id>
</element-citation>
</ref>
<ref id="B62-pharmaceutics-12-00153"><label>62.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mahadevan</surname>
<given-names>N.R.</given-names>
</name>
<name><surname>Anufreichik</surname>
<given-names>V.</given-names>
</name>
<name><surname>Rodvold</surname>
<given-names>J.J.</given-names>
</name>
<name><surname>Chiu</surname>
<given-names>K.T.</given-names>
</name>
<name><surname>Sepulveda</surname>
<given-names>H.</given-names>
</name>
<name><surname>Zanetti</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8(+) T cell priming</article-title>
<source>PLoS ONE</source>
<year>2012</year>
<volume>7</volume>
<elocation-id>e51845</elocation-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0051845</pub-id>
<pub-id pub-id-type="pmid">23272178</pub-id>
</element-citation>
</ref>
<ref id="B63-pharmaceutics-12-00153"><label>63.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mohamed</surname>
<given-names>E.</given-names>
</name>
<name><surname>Cao</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Rodriguez</surname>
<given-names>P.C.</given-names>
</name>
</person-group>
<article-title>Endoplasmic reticulum stress regulates tumor growth and anti-tumor immunity: A promising opportunity for cancer immunotherapy</article-title>
<source>Cancer Immunol. Immunother.</source>
<year>2017</year>
<volume>66</volume>
<fpage>1069</fpage>
<lpage>1078</lpage>
<pub-id pub-id-type="doi">10.1007/s00262-017-2019-6</pub-id>
<pub-id pub-id-type="pmid">28577085</pub-id>
</element-citation>
</ref>
<ref id="B64-pharmaceutics-12-00153"><label>64.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Valladeau</surname>
<given-names>J.</given-names>
</name>
<name><surname>Dezutter-Dambuyant</surname>
<given-names>C.</given-names>
</name>
<name><surname>Saeland</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells</article-title>
<source>Immunol. Res.</source>
<year>2008</year>
<volume>28</volume>
<fpage>93</fpage>
<lpage>107</lpage>
<pub-id pub-id-type="doi">10.1385/IR:28:2:93</pub-id>
</element-citation>
</ref>
<ref id="B65-pharmaceutics-12-00153"><label>65.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Feinberg</surname>
<given-names>H.</given-names>
</name>
<name><surname>Taylor</surname>
<given-names>M.E.</given-names>
</name>
<name><surname>Razi</surname>
<given-names>N.</given-names>
</name>
<name><surname>McBride</surname>
<given-names>R.</given-names>
</name>
<name><surname>Knirel</surname>
<given-names>Y.A.</given-names>
</name>
<name><surname>Graham</surname>
<given-names>S.A.</given-names>
</name>
<name><surname>Drickamer</surname>
<given-names>K.</given-names>
</name>
<name><surname>Weis</surname>
<given-names>W.I.</given-names>
</name>
</person-group>
<article-title>Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site</article-title>
<source>J. Mol. Biol.</source>
<year>2011</year>
<volume>405</volume>
<fpage>1027</fpage>
<lpage>1039</lpage>
<pub-id pub-id-type="doi">10.1016/j.jmb.2010.11.039</pub-id>
<pub-id pub-id-type="pmid">21112338</pub-id>
</element-citation>
</ref>
<ref id="B66-pharmaceutics-12-00153"><label>66.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Furio</surname>
<given-names>L.</given-names>
</name>
<name><surname>Briotet</surname>
<given-names>I.</given-names>
</name>
<name><surname>Journeaux</surname>
<given-names>A.</given-names>
</name>
<name><surname>Billard</surname>
<given-names>H.</given-names>
</name>
<name><surname>Peguet-Navarro</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Human Langerhans cells are more efficient than CD14(-)CD1c(1) dermal dendritic cells at priming naive CD4(1) T cells</article-title>
<source>J. Investig. Dermatol.</source>
<year>2010</year>
<volume>130</volume>
<fpage>1345</fpage>
<lpage>1354</lpage>
<pub-id pub-id-type="doi">10.1038/jid.2009.424</pub-id>
<pub-id pub-id-type="pmid">20107482</pub-id>
</element-citation>
</ref>
<ref id="B67-pharmaceutics-12-00153"><label>67.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Furio</surname>
<given-names>L.</given-names>
</name>
<name><surname>Billard</surname>
<given-names>H.</given-names>
</name>
<name><surname>Valladeau</surname>
<given-names>J.</given-names>
</name>
<name><surname>Peguet-Navarro</surname>
<given-names>J.</given-names>
</name>
<name><surname>Berthier-Vergnes</surname>
<given-names>O.</given-names>
</name>
</person-group>
<article-title>Poly(I:C)-Treated human Langerhans cells promote the differentiation of CD41 T cells producing IFN-gamma and IL-10</article-title>
<source>J. Investig. Dermatol.</source>
<year>2009</year>
<volume>129</volume>
<fpage>1963</fpage>
<lpage>1971</lpage>
<pub-id pub-id-type="doi">10.1038/jid.2009.21</pub-id>
<pub-id pub-id-type="pmid">19242516</pub-id>
</element-citation>
</ref>
<ref id="B68-pharmaceutics-12-00153"><label>68.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Igyártó</surname>
<given-names>B.Z.</given-names>
</name>
<name><surname>Haley</surname>
<given-names>K.</given-names>
</name>
<name><surname>Ortner</surname>
<given-names>D.</given-names>
</name>
<name><surname>Bobr</surname>
<given-names>A.</given-names>
</name>
<name><surname>Gerami-Nejad</surname>
<given-names>M.</given-names>
</name>
<name><surname>Edelson</surname>
<given-names>B.T.</given-names>
</name>
<name><surname>Zurawski</surname>
<given-names>S.M.</given-names>
</name>
<name><surname>Malissen</surname>
<given-names>B.</given-names>
</name>
<name><surname>Zurawski</surname>
<given-names>G.</given-names>
</name>
<name><surname>Berman</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses</article-title>
<source>Immunity</source>
<year>2011</year>
<volume>35</volume>
<fpage>260</fpage>
<lpage>272</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2011.06.005</pub-id>
<pub-id pub-id-type="pmid">21782478</pub-id>
</element-citation>
</ref>
<ref id="B69-pharmaceutics-12-00153"><label>69.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fehres</surname>
<given-names>C.M.</given-names>
</name>
<name><surname>Duinkerken</surname>
<given-names>S.</given-names>
</name>
<name><surname>Bruijns</surname>
<given-names>S.C.</given-names>
</name>
<name><surname>Kalay</surname>
<given-names>H.</given-names>
</name>
<name><surname>van Vliet</surname>
<given-names>S.J.</given-names>
</name>
<name><surname>Ambrosini</surname>
<given-names>M.</given-names>
</name>
<name><surname>de Gruijl</surname>
<given-names>T.D.</given-names>
</name>
<name><surname>Unger</surname>
<given-names>W.W.</given-names>
</name>
<name><surname>Garcia-Vallejo</surname>
<given-names>J.J.</given-names>
</name>
<name><surname>van Kooyk</surname>
<given-names>Y.</given-names>
</name>
</person-group>
<article-title>Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells</article-title>
<source>Cell. Mol. Immunol.</source>
<year>2017</year>
<volume>14</volume>
<fpage>360</fpage>
<lpage>370</lpage>
<pub-id pub-id-type="doi">10.1038/cmi.2015.87</pub-id>
<pub-id pub-id-type="pmid">26456691</pub-id>
</element-citation>
</ref>
<ref id="B70-pharmaceutics-12-00153"><label>70.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>O’Keeffe</surname>
<given-names>M.</given-names>
</name>
<name><surname>Mok</surname>
<given-names>W.H.</given-names>
</name>
<name><surname>Radford</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>Human dendritic cell subsets and function in health and disease</article-title>
<source>Cell. Mol. Life Sci.</source>
<year>2015</year>
<volume>72</volume>
<fpage>4309</fpage>
<lpage>4325</lpage>
<pub-id pub-id-type="doi">10.1007/s00018-015-2005-0</pub-id>
<pub-id pub-id-type="pmid">26243730</pub-id>
</element-citation>
</ref>
<ref id="B71-pharmaceutics-12-00153"><label>71.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wculek</surname>
<given-names>S.K.</given-names>
</name>
<name><surname>Cueto</surname>
<given-names>F.J.</given-names>
</name>
<name><surname>Mujal</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Melero</surname>
<given-names>I.</given-names>
</name>
<name><surname>Krummel</surname>
<given-names>M.F.</given-names>
</name>
<name><surname>Sancho</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Dendritic cells in cancer immunology and immunotherapy</article-title>
<source>Nat. Rev. Immunol.</source>
<year>2020</year>
<volume>20</volume>
<fpage>7</fpage>
<lpage>24</lpage>
<pub-id pub-id-type="doi">10.1038/s41577-019-0210-z</pub-id>
<pub-id pub-id-type="pmid">31467405</pub-id>
</element-citation>
</ref>
<ref id="B72-pharmaceutics-12-00153"><label>72.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Constantino</surname>
<given-names>J.</given-names>
</name>
<name><surname>Gomes</surname>
<given-names>C.</given-names>
</name>
<name><surname>Falcão</surname>
<given-names>A.</given-names>
</name>
<name><surname>Neves</surname>
<given-names>B.M.</given-names>
</name>
<name><surname>Cruz</surname>
<given-names>M.T.</given-names>
</name>
</person-group>
<article-title>Dendritic cell-based immunotherapy: A basic review and recent advances</article-title>
<source>Immunol. Res.</source>
<year>2017</year>
<volume>65</volume>
<fpage>798</fpage>
<lpage>810</lpage>
<pub-id pub-id-type="doi">10.1007/s12026-017-8931-1</pub-id>
<pub-id pub-id-type="pmid">28660480</pub-id>
</element-citation>
</ref>
<ref id="B73-pharmaceutics-12-00153"><label>73.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schreibelt</surname>
<given-names>G.</given-names>
</name>
<name><surname>Bol</surname>
<given-names>K.F.</given-names>
</name>
<name><surname>Westdorp</surname>
<given-names>H.</given-names>
</name>
<name><surname>Wimmers</surname>
<given-names>F.</given-names>
</name>
<name><surname>Aarntzen</surname>
<given-names>E.H.</given-names>
</name>
<name><surname>Duiveman-de Boer</surname>
<given-names>T.</given-names>
</name>
<name><surname>van de Rakt</surname>
<given-names>M.W.</given-names>
</name>
<name><surname>Scharenborg</surname>
<given-names>N.M.</given-names>
</name>
<name><surname>de Boer</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Pots</surname>
<given-names>J.M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells</article-title>
<source>Clin. Cancer Res.</source>
<year>2016</year>
<volume>22</volume>
<fpage>2155</fpage>
<lpage>2166</lpage>
<pub-id pub-id-type="doi">10.1158/1078-0432.CCR-15-2205</pub-id>
<pub-id pub-id-type="pmid">26712687</pub-id>
</element-citation>
</ref>
<ref id="B74-pharmaceutics-12-00153"><label>74.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hildner</surname>
<given-names>K.</given-names>
</name>
<name><surname>Edelson</surname>
<given-names>B.T.</given-names>
</name>
<name><surname>Purtha</surname>
<given-names>W.E.</given-names>
</name>
<name><surname>Diamond</surname>
<given-names>M.</given-names>
</name>
<name><surname>Matsushita</surname>
<given-names>H.</given-names>
</name>
<name><surname>Kohyama</surname>
<given-names>M.</given-names>
</name>
<name><surname>Calderon</surname>
<given-names>B.</given-names>
</name>
<name><surname>Schraml</surname>
<given-names>B.U.</given-names>
</name>
<name><surname>Unanue</surname>
<given-names>E.R.</given-names>
</name>
<name><surname>Diamond</surname>
<given-names>M.S.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Batf3 Deficiency Reveals a Critical Role for CD8+ Dendritic Cells in Cytotoxic T Cell Immunity</article-title>
<source>Science</source>
<year>2008</year>
<volume>322</volume>
<fpage>1097</fpage>
<lpage>1100</lpage>
<pub-id pub-id-type="doi">10.1126/science.1164206</pub-id>
<pub-id pub-id-type="pmid">19008445</pub-id>
</element-citation>
</ref>
<ref id="B75-pharmaceutics-12-00153"><label>75.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sachamitr</surname>
<given-names>P.</given-names>
</name>
<name><surname>Leishman</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Davies</surname>
<given-names>T.J.</given-names>
</name>
<name><surname>Fairchild</surname>
<given-names>P.J.</given-names>
</name>
</person-group>
<article-title>Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset</article-title>
<source>Front. Immunol.</source>
<year>2018</year>
<volume>8</volume>
<fpage>1935</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2017.01935</pub-id>
<pub-id pub-id-type="pmid">29358940</pub-id>
</element-citation>
</ref>
<ref id="B76-pharmaceutics-12-00153"><label>76.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Apter</surname>
<given-names>D.</given-names>
</name>
<name><surname>Wheeler</surname>
<given-names>C.M.</given-names>
</name>
<name><surname>Paavonen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Naud</surname>
<given-names>P.</given-names>
</name>
<name><surname>Salmerón</surname>
<given-names>J.</given-names>
</name>
<name><surname>Wheeler</surname>
<given-names>C.M.</given-names>
</name>
<name><surname>Chow</surname>
<given-names>S.N.</given-names>
</name>
<name><surname>Apter</surname>
<given-names>D.</given-names>
</name>
<name><surname>Kitchener</surname>
<given-names>H.</given-names>
</name>
<name><surname>Castellsague</surname>
<given-names>X.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): Final analysis of a double-blind, randomised study in young women</article-title>
<source>Lancet</source>
<year>2009</year>
<volume>374</volume>
<fpage>301</fpage>
<lpage>314</lpage>
<pub-id pub-id-type="pmid">19586656</pub-id>
</element-citation>
</ref>
<ref id="B77-pharmaceutics-12-00153"><label>77.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kantoff</surname>
<given-names>P.W.</given-names>
</name>
<name><surname>Higano</surname>
<given-names>C.S.</given-names>
</name>
<name><surname>Shore</surname>
<given-names>N.D.</given-names>
</name>
<name><surname>Berger</surname>
<given-names>E.R.</given-names>
</name>
<name><surname>Small</surname>
<given-names>E.J.</given-names>
</name>
<name><surname>Penson</surname>
<given-names>D.F.</given-names>
</name>
<name><surname>Redfern</surname>
<given-names>C.H.</given-names>
</name>
<name><surname>Ferrari</surname>
<given-names>A.C.</given-names>
</name>
<name><surname>Dreicer</surname>
<given-names>R.</given-names>
</name>
<name><surname>Sims</surname>
<given-names>R.B.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer</article-title>
<source>N. Engl. J. Med.</source>
<year>2010</year>
<volume>363</volume>
<fpage>411</fpage>
<lpage>422</lpage>
<pub-id pub-id-type="doi">10.1056/NEJMoa1001294</pub-id>
<pub-id pub-id-type="pmid">20818862</pub-id>
</element-citation>
</ref>
<ref id="B78-pharmaceutics-12-00153"><label>78.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Andersen</surname>
<given-names>M.H.</given-names>
</name>
</person-group>
<article-title>Immune Regulation by Self-Recognition: Novel Possibilities for Anticancer Immunotherapy</article-title>
<source>JNCI J. Natl. Cancer Inst.</source>
<year>2015</year>
<volume>107</volume>
<fpage>154</fpage>
<pub-id pub-id-type="doi">10.1093/jnci/djv154</pub-id>
</element-citation>
</ref>
<ref id="B79-pharmaceutics-12-00153"><label>79.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mant</surname>
<given-names>A.</given-names>
</name>
<name><surname>Chinnery</surname>
<given-names>F.</given-names>
</name>
<name><surname>Elliott</surname>
<given-names>T.</given-names>
</name>
<name><surname>Williams</surname>
<given-names>A.P.</given-names>
</name>
</person-group>
<article-title>The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen</article-title>
<source>Immunology</source>
<year>2012</year>
<volume>136</volume>
<fpage>163</fpage>
<lpage>175</lpage>
<pub-id pub-id-type="doi">10.1111/j.1365-2567.2012.03558.x</pub-id>
<pub-id pub-id-type="pmid">22260486</pub-id>
</element-citation>
</ref>
<ref id="B80-pharmaceutics-12-00153"><label>80.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kovacsovics-Bankowski</surname>
<given-names>M.</given-names>
</name>
<name><surname>Rock</surname>
<given-names>K.L.</given-names>
</name>
</person-group>
<article-title>A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules</article-title>
<source>Science</source>
<year>1995</year>
<volume>267</volume>
<fpage>243</fpage>
<lpage>246</lpage>
<pub-id pub-id-type="doi">10.1126/science.7809629</pub-id>
<pub-id pub-id-type="pmid">7809629</pub-id>
</element-citation>
</ref>
<ref id="B81-pharmaceutics-12-00153"><label>81.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ackerman</surname>
<given-names>A.L.</given-names>
</name>
<name><surname>Kyritsis</surname>
<given-names>C.</given-names>
</name>
<name><surname>Tampé</surname>
<given-names>R.</given-names>
</name>
<name><surname>Cresswell</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2003</year>
<volume>100</volume>
<fpage>12889</fpage>
<lpage>12894</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.1735556100</pub-id>
<pub-id pub-id-type="pmid">14561893</pub-id>
</element-citation>
</ref>
<ref id="B82-pharmaceutics-12-00153"><label>82.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Palmowski</surname>
<given-names>M.J.</given-names>
</name>
<name><surname>Gileadi</surname>
<given-names>U.</given-names>
</name>
<name><surname>Salio</surname>
<given-names>M.</given-names>
</name>
<name><surname>Gallimore</surname>
<given-names>A.</given-names>
</name>
<name><surname>Millrain</surname>
<given-names>M.</given-names>
</name>
<name><surname>James</surname>
<given-names>E.</given-names>
</name>
<name><surname>Addey</surname>
<given-names>C.</given-names>
</name>
<name><surname>Scott</surname>
<given-names>D.</given-names>
</name>
<name><surname>Dyson</surname>
<given-names>J.</given-names>
</name>
<name><surname>Simpson</surname>
<given-names>E.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Role of immunoproteasomes in cross-presentation</article-title>
<source>J. Immunol.</source>
<year>2006</year>
<volume>177</volume>
<fpage>983</fpage>
<lpage>990</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.177.2.983</pub-id>
<pub-id pub-id-type="pmid">16818754</pub-id>
</element-citation>
</ref>
<ref id="B83-pharmaceutics-12-00153"><label>83.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Embgenbroich</surname>
<given-names>M.</given-names>
</name>
<name><surname>Burgdorf</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Current Concepts of Antigen Cross-Presentation</article-title>
<source>Front. Immunol.</source>
<year>2018</year>
<volume>9</volume>
<fpage>1643</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2018.01643</pub-id>
<pub-id pub-id-type="pmid">30061897</pub-id>
</element-citation>
</ref>
<ref id="B84-pharmaceutics-12-00153"><label>84.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gros</surname>
<given-names>M.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Regulation of Antigen Export to the Cytosol During Cross-Presentation</article-title>
<source>Front. Immunol.</source>
<year>2019</year>
<volume>10</volume>
<fpage>41</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2019.00041</pub-id>
<pub-id pub-id-type="pmid">30745902</pub-id>
</element-citation>
</ref>
<ref id="B85-pharmaceutics-12-00153"><label>85.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname>
<given-names>A.Y.</given-names>
</name>
<name><surname>Bruce</surname>
<given-names>A.T.</given-names>
</name>
<name><surname>Pardoll</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Levitsky</surname>
<given-names>H.I.</given-names>
</name>
</person-group>
<article-title>In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter</article-title>
<source>Immunity</source>
<year>1996</year>
<volume>4</volume>
<fpage>349</fpage>
<lpage>355</lpage>
<pub-id pub-id-type="doi">10.1016/S1074-7613(00)80248-4</pub-id>
<pub-id pub-id-type="pmid">8612129</pub-id>
</element-citation>
</ref>
<ref id="B86-pharmaceutics-12-00153"><label>86.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kloetzel</surname>
<given-names>P.M.</given-names>
</name>
</person-group>
<article-title>Antigen processing by the proteasome</article-title>
<source>Nat. Rev. Mol. Cell Biol.</source>
<year>2001</year>
<volume>2</volume>
<fpage>179</fpage>
<lpage>187</lpage>
<pub-id pub-id-type="doi">10.1038/35056572</pub-id>
<pub-id pub-id-type="pmid">11265247</pub-id>
</element-citation>
</ref>
<ref id="B87-pharmaceutics-12-00153"><label>87.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rodriguez</surname>
<given-names>A.</given-names>
</name>
<name><surname>Regnault</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kleijmeer</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ricciardi-Castagnoli</surname>
<given-names>P.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells</article-title>
<source>Nat. Cell Biol.</source>
<year>1999</year>
<volume>1</volume>
<fpage>362</fpage>
<lpage>368</lpage>
<pub-id pub-id-type="doi">10.1038/14058</pub-id>
<pub-id pub-id-type="pmid">10559964</pub-id>
</element-citation>
</ref>
<ref id="B88-pharmaceutics-12-00153"><label>88.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shen</surname>
<given-names>L.</given-names>
</name>
<name><surname>Sigal</surname>
<given-names>L.J.</given-names>
</name>
<name><surname>Boes</surname>
<given-names>M.</given-names>
</name>
<name><surname>Rock</surname>
<given-names>K.L.</given-names>
</name>
</person-group>
<article-title>Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo</article-title>
<source>Immunity</source>
<year>2004</year>
<volume>21</volume>
<fpage>155</fpage>
<lpage>165</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2004.07.004</pub-id>
<pub-id pub-id-type="pmid">15308097</pub-id>
</element-citation>
</ref>
<ref id="B89-pharmaceutics-12-00153"><label>89.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jia</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Omri</surname>
<given-names>A.</given-names>
</name>
<name><surname>Krishnan</surname>
<given-names>L.</given-names>
</name>
<name><surname>McCluskie</surname>
<given-names>M.J.</given-names>
</name>
</person-group>
<article-title>Potential applications of nanoparticles in cancer immunotherapy</article-title>
<source>Hum. Vaccines Immunother.</source>
<year>2017</year>
<volume>13</volume>
<fpage>63</fpage>
<lpage>741</lpage>
<pub-id pub-id-type="doi">10.1080/21645515.2016.1245251</pub-id>
</element-citation>
</ref>
<ref id="B90-pharmaceutics-12-00153"><label>90.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Belz</surname>
<given-names>G.T.</given-names>
</name>
<name><surname>Behrens</surname>
<given-names>G.M.</given-names>
</name>
<name><surname>Smith</surname>
<given-names>C.M.</given-names>
</name>
<name><surname>Miller</surname>
<given-names>J.F.</given-names>
</name>
<name><surname>Jones</surname>
<given-names>C.</given-names>
</name>
<name><surname>Lejon</surname>
<given-names>K.</given-names>
</name>
<name><surname>Fathman</surname>
<given-names>C.G.</given-names>
</name>
<name><surname>Mueller</surname>
<given-names>S.N.</given-names>
</name>
<name><surname>Shortman</surname>
<given-names>K.</given-names>
</name>
<name><surname>Carbone</surname>
<given-names>F.R.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens</article-title>
<source>J. Exp. Med.</source>
<year>2002</year>
<volume>196</volume>
<fpage>1099</fpage>
<lpage>1104</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20020861</pub-id>
<pub-id pub-id-type="pmid">12391021</pub-id>
</element-citation>
</ref>
<ref id="B91-pharmaceutics-12-00153"><label>91.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sengupta</surname>
<given-names>D.</given-names>
</name>
<name><surname>Graham</surname>
<given-names>M.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>X.</given-names>
</name>
<name><surname>Cresswell</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Proteasomal degradation within endocytic organelles mediates antigen cross-presentation</article-title>
<source>EMBO J.</source>
<year>2019</year>
<volume>38</volume>
<fpage>e99266</fpage>
<pub-id pub-id-type="doi">10.15252/embj.201899266</pub-id>
<pub-id pub-id-type="pmid">31271236</pub-id>
</element-citation>
</ref>
<ref id="B92-pharmaceutics-12-00153"><label>92.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dingjan</surname>
<given-names>I.</given-names>
</name>
<name><surname>Verboogen</surname>
<given-names>D.R.</given-names>
</name>
<name><surname>Paardekooper</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Revelo</surname>
<given-names>N.H.</given-names>
</name>
<name><surname>Sittig</surname>
<given-names>S.P.</given-names>
</name>
<name><surname>Visser</surname>
<given-names>L.J.</given-names>
</name>
<name><surname>Mollard</surname>
<given-names>G.F.</given-names>
</name>
<name><surname>Henriet</surname>
<given-names>S.S.</given-names>
</name>
<name><surname>Figdor</surname>
<given-names>C.G.</given-names>
</name>
<name><surname>Ter Beest</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Lipid peroxidation causes endosomal antigen release for cross-presentation</article-title>
<source>Sci. Rep.</source>
<year>2016</year>
<volume>6</volume>
<fpage>22064</fpage>
<pub-id pub-id-type="doi">10.1038/srep22064</pub-id>
<pub-id pub-id-type="pmid">26907999</pub-id>
</element-citation>
</ref>
<ref id="B93-pharmaceutics-12-00153"><label>93.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Imai</surname>
<given-names>J.</given-names>
</name>
<name><surname>Otani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sakai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Hatta</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Purification of the subcellular compartment in which exogenous antigens undergo endoplasmic reticulum-associated degradation from dendritic cells</article-title>
<source>Heliyon</source>
<year>2016</year>
<volume>2</volume>
<fpage>e00151</fpage>
<pub-id pub-id-type="doi">10.1016/j.heliyon.2016.e00151</pub-id>
<pub-id pub-id-type="pmid">27656684</pub-id>
</element-citation>
</ref>
<ref id="B94-pharmaceutics-12-00153"><label>94.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zehner</surname>
<given-names>M.</given-names>
</name>
<name><surname>Marschall</surname>
<given-names>A.L.</given-names>
</name>
<name><surname>Bos</surname>
<given-names>E.</given-names>
</name>
<name><surname>Schloetel</surname>
<given-names>J.G.</given-names>
</name>
<name><surname>Kreer</surname>
<given-names>C.</given-names>
</name>
<name><surname>Fehrenschild</surname>
<given-names>D.</given-names>
</name>
<name><surname>Limmer</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ossendorp</surname>
<given-names>F.</given-names>
</name>
<name><surname>Lang</surname>
<given-names>T.</given-names>
</name>
<name><surname>Koster</surname>
<given-names>A.J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells</article-title>
<source>Immunity</source>
<year>2015</year>
<volume>42</volume>
<fpage>850</fpage>
<lpage>863</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2015.04.008</pub-id>
<pub-id pub-id-type="pmid">25979419</pub-id>
</element-citation>
</ref>
<ref id="B95-pharmaceutics-12-00153"><label>95.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Menager</surname>
<given-names>J.</given-names>
</name>
<name><surname>Ebstein</surname>
<given-names>F.</given-names>
</name>
<name><surname>Oger</surname>
<given-names>R.</given-names>
</name>
<name><surname>Hulin</surname>
<given-names>P.</given-names>
</name>
<name><surname>Nedellec</surname>
<given-names>S.</given-names>
</name>
<name><surname>Duverger</surname>
<given-names>E.</given-names>
</name>
<name><surname>Lehmann</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kloetzel</surname>
<given-names>P.M.</given-names>
</name>
<name><surname>Jotereau</surname>
<given-names>F.</given-names>
</name>
<name><surname>Guilloux</surname>
<given-names>Y.</given-names>
</name>
</person-group>
<article-title>Cross-presentation of synthetic long peptides by human dendritic cells: A process dependent on ERAD component p97/VCP but not sec61 and/or Derlin-1</article-title>
<source>PLoS ONE</source>
<year>2014</year>
<volume>9</volume>
<elocation-id>e89897</elocation-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0089897</pub-id>
<pub-id pub-id-type="pmid">24587108</pub-id>
</element-citation>
</ref>
<ref id="B96-pharmaceutics-12-00153"><label>96.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Delamarre</surname>
<given-names>L.</given-names>
</name>
<name><surname>Pack</surname>
<given-names>M.</given-names>
</name>
<name><surname>Chang</surname>
<given-names>H.</given-names>
</name>
<name><surname>Mellman</surname>
<given-names>I.</given-names>
</name>
<name><surname>Trombetta</surname>
<given-names>E.S.</given-names>
</name>
</person-group>
<article-title>Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate</article-title>
<source>Science</source>
<year>2005</year>
<volume>307</volume>
<fpage>1630</fpage>
<lpage>1634</lpage>
<pub-id pub-id-type="doi">10.1126/science.1108003</pub-id>
<pub-id pub-id-type="pmid">15761154</pub-id>
</element-citation>
</ref>
<ref id="B97-pharmaceutics-12-00153"><label>97.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lennon-Dumenil</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Bakker</surname>
<given-names>A.H.</given-names>
</name>
<name><surname>Wolf-Bryant</surname>
<given-names>P.</given-names>
</name>
<name><surname>Ploegh</surname>
<given-names>H.L.</given-names>
</name>
<name><surname>Lagaudriere-Gesbert</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>A closer look at proteolysis and MHC-class-II-restricted antigen presentation</article-title>
<source>Curr. Opin. Immunol.</source>
<year>2002</year>
<volume>14</volume>
<fpage>15</fpage>
<lpage>21</lpage>
<pub-id pub-id-type="doi">10.1016/S0952-7915(01)00293-X</pub-id>
<pub-id pub-id-type="pmid">11790528</pub-id>
</element-citation>
</ref>
<ref id="B98-pharmaceutics-12-00153"><label>98.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Savina</surname>
<given-names>A.</given-names>
</name>
<name><surname>Jancic</surname>
<given-names>C.</given-names>
</name>
<name><surname>Hugues</surname>
<given-names>S.</given-names>
</name>
<name><surname>Guermonprez</surname>
<given-names>P.</given-names>
</name>
<name><surname>Vargas</surname>
<given-names>P.</given-names>
</name>
<name><surname>Moura</surname>
<given-names>I.C.</given-names>
</name>
<name><surname>Lennon-Duménil</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Seabra</surname>
<given-names>M.C.</given-names>
</name>
<name><surname>Raposo</surname>
<given-names>G.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>NOX<sub>2</sub>
controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells</article-title>
<source>Cell</source>
<year>2006</year>
<volume>126</volume>
<fpage>205</fpage>
<lpage>218</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2006.05.035</pub-id>
<pub-id pub-id-type="pmid">16839887</pub-id>
</element-citation>
</ref>
<ref id="B99-pharmaceutics-12-00153"><label>99.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Savina</surname>
<given-names>A.</given-names>
</name>
<name><surname>Peres</surname>
<given-names>A.</given-names>
</name>
<name><surname>Cebrian</surname>
<given-names>I.</given-names>
</name>
<name><surname>Carmo</surname>
<given-names>N.</given-names>
</name>
<name><surname>Moita</surname>
<given-names>C.</given-names>
</name>
<name><surname>Hacohen</surname>
<given-names>N.</given-names>
</name>
<name><surname>Moita</surname>
<given-names>L.F.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells</article-title>
<source>Immunity</source>
<year>2009</year>
<volume>30</volume>
<fpage>544</fpage>
<lpage>555</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2009.01.013</pub-id>
<pub-id pub-id-type="pmid">19328020</pub-id>
</element-citation>
</ref>
<ref id="B100-pharmaceutics-12-00153"><label>100.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Claus</surname>
<given-names>V.</given-names>
</name>
<name><surname>Jahraus</surname>
<given-names>A.</given-names>
</name>
<name><surname>Tjelle</surname>
<given-names>T.</given-names>
</name>
<name><surname>Berg</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kirschke</surname>
<given-names>H.</given-names>
</name>
<name><surname>Faulstich</surname>
<given-names>H.</given-names>
</name>
<name><surname>Griffiths</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes</article-title>
<source>J. Biol. Chem.</source>
<year>1998</year>
<volume>273</volume>
<fpage>9842</fpage>
<lpage>9851</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.273.16.9842</pub-id>
<pub-id pub-id-type="pmid">9545324</pub-id>
</element-citation>
</ref>
<ref id="B101-pharmaceutics-12-00153"><label>101.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Trombetta</surname>
<given-names>E.S.</given-names>
</name>
<name><surname>Ebersold</surname>
<given-names>M.</given-names>
</name>
<name><surname>Garrett</surname>
<given-names>W.</given-names>
</name>
<name><surname>Pypaert</surname>
<given-names>M.</given-names>
</name>
<name><surname>Mellman</surname>
<given-names>I.</given-names>
</name>
</person-group>
<article-title>Activation of lysosomal function during dendritic cell maturation</article-title>
<source>Science</source>
<year>2003</year>
<volume>299</volume>
<fpage>1400</fpage>
<lpage>1403</lpage>
<pub-id pub-id-type="doi">10.1126/science.1080106</pub-id>
<pub-id pub-id-type="pmid">12610307</pub-id>
</element-citation>
</ref>
<ref id="B102-pharmaceutics-12-00153"><label>102.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Forgac</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Vacuolar ATPases: Rotary proton pumps in physiology and pathophysiology</article-title>
<source>Nat. Rev. Mol. Cell Biol.</source>
<year>2007</year>
<volume>8</volume>
<fpage>917</fpage>
<lpage>929</lpage>
<pub-id pub-id-type="doi">10.1038/nrm2272</pub-id>
<pub-id pub-id-type="pmid">17912264</pub-id>
</element-citation>
</ref>
<ref id="B103-pharmaceutics-12-00153"><label>103.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liberman</surname>
<given-names>R.</given-names>
</name>
<name><surname>Bond</surname>
<given-names>S.</given-names>
</name>
<name><surname>Shainheit</surname>
<given-names>M.G.</given-names>
</name>
<name><surname>Stadecker</surname>
<given-names>M.J.</given-names>
</name>
<name><surname>Forgac</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase/mTOR-dependent pathway</article-title>
<source>J. Biol. Chem.</source>
<year>2014</year>
<volume>289</volume>
<fpage>1355</fpage>
<lpage>1363</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.M113.524561</pub-id>
<pub-id pub-id-type="pmid">24273170</pub-id>
</element-citation>
</ref>
<ref id="B104-pharmaceutics-12-00153"><label>104.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gerriets</surname>
<given-names>V.A.</given-names>
</name>
<name><surname>Kishton</surname>
<given-names>R.J.</given-names>
</name>
<name><surname>Johnson</surname>
<given-names>M.O.</given-names>
</name>
<name><surname>Cohen</surname>
<given-names>S.</given-names>
</name>
<name><surname>Siska</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>Nichols</surname>
<given-names>A.G.</given-names>
</name>
<name><surname>Warmoes</surname>
<given-names>M.O.</given-names>
</name>
<name><surname>de Cubas</surname>
<given-names>A.A.</given-names>
</name>
<name><surname>MacIver</surname>
<given-names>N.J.</given-names>
</name>
<name><surname>Locasale</surname>
<given-names>J.W.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression</article-title>
<source>Nat. Immunol.</source>
<year>2016</year>
<volume>12</volume>
<fpage>1459</fpage>
<lpage>1466</lpage>
<pub-id pub-id-type="doi">10.1038/ni.3577</pub-id>
<pub-id pub-id-type="pmid">27695003</pub-id>
</element-citation>
</ref>
<ref id="B105-pharmaceutics-12-00153"><label>105.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nguyen</surname>
<given-names>G.T.</given-names>
</name>
<name><surname>Green</surname>
<given-names>E.R.</given-names>
</name>
<name><surname>Mecsas</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance</article-title>
<source>Front. Cell. Infect. Microbiol.</source>
<year>2017</year>
<volume>7</volume>
<fpage>373</fpage>
<pub-id pub-id-type="doi">10.3389/fcimb.2017.00373</pub-id>
<pub-id pub-id-type="pmid">28890882</pub-id>
</element-citation>
</ref>
<ref id="B106-pharmaceutics-12-00153"><label>106.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jancic</surname>
<given-names>C.</given-names>
</name>
<name><surname>Savina</surname>
<given-names>A.</given-names>
</name>
<name><surname>Wasmeier</surname>
<given-names>C.</given-names>
</name>
<name><surname>Tolmachova</surname>
<given-names>T.</given-names>
</name>
<name><surname>El-Benna</surname>
<given-names>J.</given-names>
</name>
<name><surname>Dang</surname>
<given-names>P.M.</given-names>
</name>
<name><surname>Pascolo</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gougerot-Pocdalo</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Raposo</surname>
<given-names>G.</given-names>
</name>
<name><surname>Seabra</surname>
<given-names>M.C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes</article-title>
<source>Nat. Cell Biol.</source>
<year>2007</year>
<volume>9</volume>
<fpage>367</fpage>
<lpage>378</lpage>
<pub-id pub-id-type="doi">10.1038/ncb1552</pub-id>
<pub-id pub-id-type="pmid">17351642</pub-id>
</element-citation>
</ref>
<ref id="B107-pharmaceutics-12-00153"><label>107.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paardekooper</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Dingjan</surname>
<given-names>I.</given-names>
</name>
<name><surname>Linders</surname>
<given-names>P.T.A.</given-names>
</name>
<name><surname>Staal</surname>
<given-names>A.H.J.</given-names>
</name>
<name><surname>Cristescu</surname>
<given-names>S.M.</given-names>
</name>
<name><surname>Verberk</surname>
<given-names>W.</given-names>
</name>
<name><surname>van den Bogaart</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second</article-title>
<source>Front. Immunol.</source>
<year>2019</year>
<volume>10</volume>
<fpage>1216</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2019.01216</pub-id>
<pub-id pub-id-type="pmid">31191556</pub-id>
</element-citation>
</ref>
<ref id="B108-pharmaceutics-12-00153"><label>108.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dingjan</surname>
<given-names>I.</given-names>
</name>
<name><surname>Paardekooper</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Verboogen</surname>
<given-names>D.R.J.</given-names>
</name>
<name><surname>von Mollard</surname>
<given-names>G.F.</given-names>
</name>
<name><surname>Ter Beest</surname>
<given-names>M.</given-names>
</name>
<name><surname>van den Bogaart</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release</article-title>
<source>Eur. J. Cell Biol.</source>
<year>2017</year>
<volume>96</volume>
<fpage>705</fpage>
<lpage>714</lpage>
<pub-id pub-id-type="doi">10.1016/j.ejcb.2017.06.007</pub-id>
<pub-id pub-id-type="pmid">28688576</pub-id>
</element-citation>
</ref>
<ref id="B109-pharmaceutics-12-00153"><label>109.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matheoud</surname>
<given-names>D.</given-names>
</name>
<name><surname>Moradin</surname>
<given-names>N.</given-names>
</name>
<name><surname>Bellemare-Pelletier</surname>
<given-names>A.</given-names>
</name>
<name><surname>Shio</surname>
<given-names>M.T.</given-names>
</name>
<name><surname>Hong</surname>
<given-names>W.J.</given-names>
</name>
<name><surname>Olivier</surname>
<given-names>M.</given-names>
</name>
<name><surname>Gagnon</surname>
<given-names>E.</given-names>
</name>
<name><surname>Desjardins</surname>
<given-names>M.</given-names>
</name>
<name><surname>Descoteaux</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title><italic>Leishmania</italic>
evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8</article-title>
<source>Cell Host Microbe</source>
<year>2013</year>
<volume>14</volume>
<fpage>15</fpage>
<lpage>25</lpage>
<pub-id pub-id-type="doi">10.1016/j.chom.2013.06.003</pub-id>
<pub-id pub-id-type="pmid">23870310</pub-id>
</element-citation>
</ref>
<ref id="B110-pharmaceutics-12-00153"><label>110.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baptista</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Keszei</surname>
<given-names>M.</given-names>
</name>
<name><surname>Oliveira</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sunahara</surname>
<given-names>K.K.</given-names>
</name>
<name><surname>Andersson</surname>
<given-names>J.</given-names>
</name>
<name><surname>Dahlberg</surname>
<given-names>C.I.</given-names>
</name>
<name><surname>Worth</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Lieden</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kuo</surname>
<given-names>I.C.</given-names>
</name>
<name><surname>Wallin</surname>
<given-names>R.P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells</article-title>
<source>Nat. Commun.</source>
<year>2016</year>
<volume>7</volume>
<fpage>12175</fpage>
<pub-id pub-id-type="doi">10.1038/ncomms12175</pub-id>
<pub-id pub-id-type="pmid">27425374</pub-id>
</element-citation>
</ref>
<ref id="B111-pharmaceutics-12-00153"><label>111.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ding</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Li</surname>
<given-names>X.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>X.</given-names>
</name>
<name><surname>Gu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>D.</given-names>
</name>
<name><surname>Cao</surname>
<given-names>X.</given-names>
</name>
</person-group>
<article-title>The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation</article-title>
<source>Nat. Immunol.</source>
<year>2016</year>
<volume>17</volume>
<fpage>1167</fpage>
<lpage>1175</lpage>
<pub-id pub-id-type="doi">10.1038/ni.3535</pub-id>
<pub-id pub-id-type="pmid">27548433</pub-id>
</element-citation>
</ref>
<ref id="B112-pharmaceutics-12-00153"><label>112.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stegmann</surname>
<given-names>T.</given-names>
</name>
<name><surname>Booy</surname>
<given-names>F.P.</given-names>
</name>
<name><surname>Wilschut</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Effects of low pH on influenza virus. Activation and inactivation of the membrane fusion capacity of the hemagglutinin</article-title>
<source>J. Biol. Chem.</source>
<year>1987</year>
<volume>262</volume>
<fpage>17744</fpage>
<lpage>17749</lpage>
<pub-id pub-id-type="pmid">3693369</pub-id>
</element-citation>
</ref>
<ref id="B113-pharmaceutics-12-00153"><label>113.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roche</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gaudin</surname>
<given-names>Y.</given-names>
</name>
</person-group>
<article-title>Characterization of the equilibrium between the native and fusion-inactive conformation of rabies virus glycoprotein indicates that the fusion complex is made of several trimers</article-title>
<source>Virology</source>
<year>2002</year>
<volume>297</volume>
<fpage>128</fpage>
<lpage>135</lpage>
<pub-id pub-id-type="doi">10.1006/viro.2002.1429</pub-id>
<pub-id pub-id-type="pmid">12083843</pub-id>
</element-citation>
</ref>
<ref id="B114-pharmaceutics-12-00153"><label>114.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Komala Sari</surname>
<given-names>T.</given-names>
</name>
<name><surname>Pritchard</surname>
<given-names>S.M.</given-names>
</name>
<name><surname>Cunha</surname>
<given-names>C.W.</given-names>
</name>
<name><surname>Wudiri</surname>
<given-names>G.A.</given-names>
</name>
<name><surname>Laws</surname>
<given-names>E.I.</given-names>
</name>
<name><surname>Aguilar</surname>
<given-names>H.C.</given-names>
</name>
<name><surname>Taus</surname>
<given-names>N.S.</given-names>
</name>
<name><surname>Nicola</surname>
<given-names>A.V.</given-names>
</name>
</person-group>
<article-title>Contributions of herpes simplex virus 1 envelope proteins to entry by endocytosis</article-title>
<source>J. Virol.</source>
<year>2013</year>
<volume>87</volume>
<fpage>13922</fpage>
<lpage>13926</lpage>
<pub-id pub-id-type="doi">10.1128/JVI.02500-13</pub-id>
<pub-id pub-id-type="pmid">24109213</pub-id>
</element-citation>
</ref>
<ref id="B115-pharmaceutics-12-00153"><label>115.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gil-Torregrosa</surname>
<given-names>B.C.</given-names>
</name>
<name><surname>Lennon-Duménil</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Kessler</surname>
<given-names>B.</given-names>
</name>
<name><surname>Guermonprez</surname>
<given-names>P.</given-names>
</name>
<name><surname>Ploegh</surname>
<given-names>H.L.</given-names>
</name>
<name><surname>Fruci</surname>
<given-names>D.</given-names>
</name>
<name><surname>van Endert</surname>
<given-names>P.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Control of cross-presentation during dendritic cell maturation</article-title>
<source>Eur. J. Immunol.</source>
<year>2004</year>
<volume>2</volume>
<fpage>398</fpage>
<lpage>407</lpage>
<pub-id pub-id-type="doi">10.1002/eji.200324508</pub-id>
</element-citation>
</ref>
<ref id="B116-pharmaceutics-12-00153"><label>116.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Belizaire</surname>
<given-names>R.</given-names>
</name>
<name><surname>Unanue</surname>
<given-names>E.R.</given-names>
</name>
</person-group>
<article-title>Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2009</year>
<volume>106</volume>
<fpage>17463</fpage>
<lpage>17468</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0908583106</pub-id>
<pub-id pub-id-type="pmid">19805168</pub-id>
</element-citation>
</ref>
<ref id="B117-pharmaceutics-12-00153"><label>117.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Accapezzato</surname>
<given-names>D.</given-names>
</name>
<name><surname>Visco</surname>
<given-names>V.</given-names>
</name>
<name><surname>Francavilla</surname>
<given-names>V.</given-names>
</name>
<name><surname>Molette</surname>
<given-names>C.</given-names>
</name>
<name><surname>Donato</surname>
<given-names>T.</given-names>
</name>
<name><surname>Paroli</surname>
<given-names>M.</given-names>
</name>
<name><surname>Mondelli</surname>
<given-names>M.U.</given-names>
</name>
<name><surname>Doria</surname>
<given-names>M.</given-names>
</name>
<name><surname>Torrisi</surname>
<given-names>M.R.</given-names>
</name>
<name><surname>Barnaba</surname>
<given-names>V.</given-names>
</name>
</person-group>
<article-title>Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo</article-title>
<source>J. Exp. Med.</source>
<year>2005</year>
<volume>202</volume>
<fpage>817</fpage>
<lpage>828</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20051106</pub-id>
<pub-id pub-id-type="pmid">16157687</pub-id>
</element-citation>
</ref>
<ref id="B118-pharmaceutics-12-00153"><label>118.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chatterjee</surname>
<given-names>B.</given-names>
</name>
<name><surname>Smed-Sörensen</surname>
<given-names>A.</given-names>
</name>
<name><surname>Cohn</surname>
<given-names>L.</given-names>
</name>
<name><surname>Chalouni</surname>
<given-names>C.</given-names>
</name>
<name><surname>Vandlen</surname>
<given-names>R.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>B.C.</given-names>
</name>
<name><surname>Widger</surname>
<given-names>J.</given-names>
</name>
<name><surname>Keler</surname>
<given-names>T.</given-names>
</name>
<name><surname>Delamarre</surname>
<given-names>L.</given-names>
</name>
<name><surname>Mellman</surname>
<given-names>I.</given-names>
</name>
</person-group>
<article-title>Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells</article-title>
<source>Blood</source>
<year>2012</year>
<volume>120</volume>
<fpage>2011</fpage>
<lpage>2020</lpage>
<pub-id pub-id-type="doi">10.1182/blood-2012-01-402370</pub-id>
<pub-id pub-id-type="pmid">22791285</pub-id>
</element-citation>
</ref>
<ref id="B119-pharmaceutics-12-00153"><label>119.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>X.</given-names>
</name>
<name><surname>Han</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>J.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>D.</given-names>
</name>
<name><surname>Ma</surname>
<given-names>G.</given-names>
</name>
<name><surname>Li</surname>
<given-names>C.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Kong</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Nanovaccine Incorporated with Hydroxychloroquine Enhances Antigen Cross-Presentation and Promotes Antitumor Immune Responses</article-title>
<source>ACS Appl. Mater. Interfaces</source>
<year>2018</year>
<volume>10</volume>
<fpage>30983</fpage>
<lpage>30993</lpage>
<pub-id pub-id-type="doi">10.1021/acsami.8b09348</pub-id>
<pub-id pub-id-type="pmid">30136844</pub-id>
</element-citation>
</ref>
<ref id="B120-pharmaceutics-12-00153"><label>120.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burgdorf</surname>
<given-names>S.</given-names>
</name>
<name><surname>Kautz</surname>
<given-names>A.</given-names>
</name>
<name><surname>Böhnert</surname>
<given-names>V.</given-names>
</name>
<name><surname>Knolle</surname>
<given-names>P.A.</given-names>
</name>
<name><surname>Kurts</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation</article-title>
<source>Science</source>
<year>2007</year>
<volume>316</volume>
<fpage>612</fpage>
<lpage>616</lpage>
<pub-id pub-id-type="doi">10.1126/science.1137971</pub-id>
<pub-id pub-id-type="pmid">17463291</pub-id>
</element-citation>
</ref>
<ref id="B121-pharmaceutics-12-00153"><label>121.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tacken</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>de Vries</surname>
<given-names>I.J.</given-names>
</name>
<name><surname>Gijzen</surname>
<given-names>K.</given-names>
</name>
<name><surname>Joosten</surname>
<given-names>B.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>D.</given-names>
</name>
<name><surname>Rother</surname>
<given-names>R.P.</given-names>
</name>
<name><surname>Faas</surname>
<given-names>S.J.</given-names>
</name>
<name><surname>Punt</surname>
<given-names>C.J.</given-names>
</name>
<name><surname>Torensma</surname>
<given-names>R.</given-names>
</name>
<name><surname>Adema</surname>
<given-names>G.J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody</article-title>
<source>Blood</source>
<year>2005</year>
<volume>106</volume>
<fpage>1278</fpage>
<lpage>1285</lpage>
<pub-id pub-id-type="doi">10.1182/blood-2005-01-0318</pub-id>
<pub-id pub-id-type="pmid">15878980</pub-id>
</element-citation>
</ref>
<ref id="B122-pharmaceutics-12-00153"><label>122.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tacken</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>Ginter</surname>
<given-names>W.</given-names>
</name>
<name><surname>Berod</surname>
<given-names>L.</given-names>
</name>
<name><surname>Cruz</surname>
<given-names>L.J.</given-names>
</name>
<name><surname>Joosten</surname>
<given-names>B.</given-names>
</name>
<name><surname>Sparwasser</surname>
<given-names>T.</given-names>
</name>
<name><surname>Figdor</surname>
<given-names>C.G.</given-names>
</name>
<name><surname>Cambi</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation</article-title>
<source>Blood</source>
<year>2011</year>
<volume>118</volume>
<fpage>4111</fpage>
<lpage>4119</lpage>
<pub-id pub-id-type="doi">10.1182/blood-2011-04-346957</pub-id>
<pub-id pub-id-type="pmid">21860028</pub-id>
</element-citation>
</ref>
<ref id="B123-pharmaceutics-12-00153"><label>123.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cohn</surname>
<given-names>L.</given-names>
</name>
<name><surname>Chatterjee</surname>
<given-names>B.</given-names>
</name>
<name><surname>Esselborn</surname>
<given-names>F.</given-names>
</name>
<name><surname>Smed-Sörensen</surname>
<given-names>A.</given-names>
</name>
<name><surname>Nakamura</surname>
<given-names>N.</given-names>
</name>
<name><surname>Chalouni</surname>
<given-names>C.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>B.C.</given-names>
</name>
<name><surname>Vandlen</surname>
<given-names>R.</given-names>
</name>
<name><surname>Keler</surname>
<given-names>T.</given-names>
</name>
<name><surname>Lauer</surname>
<given-names>P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation</article-title>
<source>J. Exp. Med.</source>
<year>2013</year>
<volume>210</volume>
<fpage>1049</fpage>
<lpage>1063</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20121251</pub-id>
<pub-id pub-id-type="pmid">23569326</pub-id>
</element-citation>
</ref>
<ref id="B124-pharmaceutics-12-00153"><label>124.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gagnon</surname>
<given-names>E.</given-names>
</name>
<name><surname>Duclos</surname>
<given-names>S.</given-names>
</name>
<name><surname>Rondeau</surname>
<given-names>C.</given-names>
</name>
<name><surname>Chevet</surname>
<given-names>E.</given-names>
</name>
<name><surname>Cameron</surname>
<given-names>P.H.</given-names>
</name>
<name><surname>Steele-Mortimer</surname>
<given-names>O.</given-names>
</name>
<name><surname>Paiement</surname>
<given-names>J.</given-names>
</name>
<name><surname>Bergeron</surname>
<given-names>J.J.</given-names>
</name>
<name><surname>Desjardins</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages</article-title>
<source>Cell</source>
<year>2002</year>
<volume>110</volume>
<fpage>119</fpage>
<lpage>131</lpage>
<pub-id pub-id-type="doi">10.1016/S0092-8674(02)00797-3</pub-id>
<pub-id pub-id-type="pmid">12151002</pub-id>
</element-citation>
</ref>
<ref id="B125-pharmaceutics-12-00153"><label>125.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Houde</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bertholet</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gagnon</surname>
<given-names>E.</given-names>
</name>
<name><surname>Brunet</surname>
<given-names>S.</given-names>
</name>
<name><surname>Goyette</surname>
<given-names>G.</given-names>
</name>
<name><surname>Laplante</surname>
<given-names>A.</given-names>
</name>
<name><surname>Princiotta</surname>
<given-names>M.F.</given-names>
</name>
<name><surname>Thibault</surname>
<given-names>P.</given-names>
</name>
<name><surname>Sacks</surname>
<given-names>D.</given-names>
</name>
<name><surname>Desjardins</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Phagosomes are competent organelles for antigen cross-presentation</article-title>
<source>Nature</source>
<year>2003</year>
<volume>425</volume>
<fpage>402</fpage>
<lpage>406</lpage>
<pub-id pub-id-type="doi">10.1038/nature01912</pub-id>
<pub-id pub-id-type="pmid">14508490</pub-id>
</element-citation>
</ref>
<ref id="B126-pharmaceutics-12-00153"><label>126.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guermonprez</surname>
<given-names>P.</given-names>
</name>
<name><surname>Saveanu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Kleijmeer</surname>
<given-names>M.</given-names>
</name>
<name><surname>Davoust</surname>
<given-names>J.</given-names>
</name>
<name><surname>Van Endert</surname>
<given-names>P.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells</article-title>
<source>Nature</source>
<year>2003</year>
<volume>425</volume>
<fpage>397</fpage>
<lpage>402</lpage>
<pub-id pub-id-type="doi">10.1038/nature01911</pub-id>
<pub-id pub-id-type="pmid">14508489</pub-id>
</element-citation>
</ref>
<ref id="B127-pharmaceutics-12-00153"><label>127.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eden</surname>
<given-names>E.R.</given-names>
</name>
</person-group>
<article-title>The formation and function of ER-endosome membrane contact sites</article-title>
<source>Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids</source>
<year>2016</year>
<volume>1861</volume>
<fpage>874</fpage>
<lpage>879</lpage>
<pub-id pub-id-type="doi">10.1016/j.bbalip.2016.01.020</pub-id>
</element-citation>
</ref>
<ref id="B128-pharmaceutics-12-00153"><label>128.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cebrian</surname>
<given-names>I.</given-names>
</name>
<name><surname>Visentin</surname>
<given-names>G.</given-names>
</name>
<name><surname>Blanchard</surname>
<given-names>N.</given-names>
</name>
<name><surname>Jouve</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bobard</surname>
<given-names>A.</given-names>
</name>
<name><surname>Moita</surname>
<given-names>C.</given-names>
</name>
<name><surname>Enninga</surname>
<given-names>J.</given-names>
</name>
<name><surname>Moita</surname>
<given-names>L.F.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
<name><surname>Savina</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells</article-title>
<source>Cell</source>
<year>2011</year>
<volume>147</volume>
<fpage>1355</fpage>
<lpage>1368</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2011.11.021</pub-id>
<pub-id pub-id-type="pmid">22153078</pub-id>
</element-citation>
</ref>
<ref id="B129-pharmaceutics-12-00153"><label>129.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nair-Gupta</surname>
<given-names>P.</given-names>
</name>
<name><surname>Baccarini</surname>
<given-names>A.</given-names>
</name>
<name><surname>Tung</surname>
<given-names>N.</given-names>
</name>
<name><surname>Seyffer</surname>
<given-names>F.</given-names>
</name>
<name><surname>Florey</surname>
<given-names>O.</given-names>
</name>
<name><surname>Huang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Banerjee</surname>
<given-names>M.</given-names>
</name>
<name><surname>Overholtzer</surname>
<given-names>M.</given-names>
</name>
<name><surname>Roche</surname>
<given-names>P.A.</given-names>
</name>
<name><surname>Tampe</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation</article-title>
<source>Cell</source>
<year>2014</year>
<volume>158</volume>
<fpage>506</fpage>
<lpage>521</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2014.04.054</pub-id>
<pub-id pub-id-type="pmid">25083866</pub-id>
</element-citation>
</ref>
<ref id="B130-pharmaceutics-12-00153"><label>130.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alloatti</surname>
<given-names>A.</given-names>
</name>
<name><surname>Rookhuizen</surname>
<given-names>D.C.</given-names>
</name>
<name><surname>Joannas</surname>
<given-names>L.</given-names>
</name>
<name><surname>Carpier</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Iborra</surname>
<given-names>S.</given-names>
</name>
<name><surname>Magalhaes</surname>
<given-names>J.G.</given-names>
</name>
<name><surname>Yatim</surname>
<given-names>N.</given-names>
</name>
<name><surname>Kozik</surname>
<given-names>P.</given-names>
</name>
<name><surname>Sancho</surname>
<given-names>D.</given-names>
</name>
<name><surname>Albert</surname>
<given-names>M.L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity</article-title>
<source>J. Exp. Med.</source>
<year>2017</year>
<volume>214</volume>
<fpage>2231</fpage>
<lpage>2241</lpage>
<pub-id pub-id-type="doi">10.1084/jem.20170229</pub-id>
<pub-id pub-id-type="pmid">28663435</pub-id>
</element-citation>
</ref>
<ref id="B131-pharmaceutics-12-00153"><label>131.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname>
<given-names>S.J.</given-names>
</name>
<name><surname>Niknafs</surname>
<given-names>Y.S.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>S.H.</given-names>
</name>
<name><surname>Oravecz-Wilson</surname>
<given-names>K.</given-names>
</name>
<name><surname>Zajac</surname>
<given-names>C.</given-names>
</name>
<name><surname>Toubai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Sun</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Prasad</surname>
<given-names>J.</given-names>
</name>
<name><surname>Peltier</surname>
<given-names>D.</given-names>
</name>
<name><surname>Fujiwara</surname>
<given-names>H.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A critical analysis of the role of SNARE protein SEC22B in antigen cross-presentation</article-title>
<source>Cell Rep.</source>
<year>2017</year>
<volume>19</volume>
<fpage>2645</fpage>
<lpage>2656</lpage>
<pub-id pub-id-type="doi">10.1016/j.celrep.2017.06.013</pub-id>
<pub-id pub-id-type="pmid">28658614</pub-id>
</element-citation>
</ref>
<ref id="B132-pharmaceutics-12-00153"><label>132.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Montealegre</surname>
<given-names>S.</given-names>
</name>
<name><surname>van Endert</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>MHC class I cross-presentation: Stage lights on Sec22b</article-title>
<source>Trends Immunol.</source>
<year>2017</year>
<volume>38</volume>
<fpage>618</fpage>
<lpage>662</lpage>
<pub-id pub-id-type="doi">10.1016/j.it.2017.07.002</pub-id>
<pub-id pub-id-type="pmid">28743621</pub-id>
</element-citation>
</ref>
<ref id="B133-pharmaceutics-12-00153"><label>133.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Giodini</surname>
<given-names>A.</given-names>
</name>
<name><surname>Cresswell</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Hsp90-mediated cytosolic refolding of exogenous proteins internalized by dendritic cells</article-title>
<source>EMBO J.</source>
<year>2008</year>
<volume>27</volume>
<fpage>201</fpage>
<lpage>211</lpage>
<pub-id pub-id-type="doi">10.1038/sj.emboj.7601941</pub-id>
<pub-id pub-id-type="pmid">18046456</pub-id>
</element-citation>
</ref>
<ref id="B134-pharmaceutics-12-00153"><label>134.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Imai</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hasegawa</surname>
<given-names>H.</given-names>
</name>
<name><surname>Maruya</surname>
<given-names>M.</given-names>
</name>
<name><surname>Koyasu</surname>
<given-names>S.</given-names>
</name>
<name><surname>Yahara</surname>
<given-names>I.</given-names>
</name>
</person-group>
<article-title>Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells</article-title>
<source>Int. Immunol.</source>
<year>2005</year>
<volume>17</volume>
<fpage>45</fpage>
<lpage>53</lpage>
<pub-id pub-id-type="doi">10.1093/intimm/dxh184</pub-id>
<pub-id pub-id-type="pmid">15546887</pub-id>
</element-citation>
</ref>
<ref id="B135-pharmaceutics-12-00153"><label>135.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Singh</surname>
<given-names>R.</given-names>
</name>
<name><surname>Cresswell</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Defective cross-presentation of viral antigens in GILT-free mice</article-title>
<source>Science</source>
<year>2010</year>
<volume>328</volume>
<fpage>1394</fpage>
<lpage>1398</lpage>
<pub-id pub-id-type="doi">10.1126/science.1189176</pub-id>
<pub-id pub-id-type="pmid">20538950</pub-id>
</element-citation>
</ref>
<ref id="B136-pharmaceutics-12-00153"><label>136.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hurst</surname>
<given-names>K.E.</given-names>
</name>
<name><surname>Lawrence</surname>
<given-names>K.A.</given-names>
</name>
<name><surname>Reyes Angeles</surname>
<given-names>L.</given-names>
</name>
<name><surname>Ye</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>J.</given-names>
</name>
<name><surname>Townsend</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Dolloff</surname>
<given-names>N.</given-names>
</name>
<name><surname>Thaxton</surname>
<given-names>J.E.</given-names>
</name>
</person-group>
<article-title>Endoplasmic Reticulum protein disulfide isomerase shapes T cell efficacy for adoptive cellular therapy of tumors</article-title>
<source>Cells</source>
<year>2019</year>
<volume>8</volume>
<elocation-id>1514</elocation-id>
<pub-id pub-id-type="doi">10.3390/cells8121514</pub-id>
</element-citation>
</ref>
<ref id="B137-pharmaceutics-12-00153"><label>137.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morito</surname>
<given-names>D.</given-names>
</name>
<name><surname>Nagata</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>ER Stress Proteins in Autoimmune and Inflammatory Diseases</article-title>
<source>Front. Immunol.</source>
<year>2012</year>
<volume>3</volume>
<fpage>48</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2012.00048</pub-id>
<pub-id pub-id-type="pmid">22566930</pub-id>
</element-citation>
</ref>
<ref id="B138-pharmaceutics-12-00153"><label>138.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zehner</surname>
<given-names>M.</given-names>
</name>
<name><surname>Chasan</surname>
<given-names>A.I.</given-names>
</name>
<name><surname>Schuette</surname>
<given-names>V.</given-names>
</name>
<name><surname>Embgenbroich</surname>
<given-names>M.</given-names>
</name>
<name><surname>Quast</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kolanus</surname>
<given-names>W.</given-names>
</name>
<name><surname>Burgdorf</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2011</year>
<volume>108</volume>
<fpage>9933</fpage>
<lpage>9938</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.1102397108</pub-id>
<pub-id pub-id-type="pmid">21628571</pub-id>
</element-citation>
</ref>
<ref id="B139-pharmaceutics-12-00153"><label>139.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sancho</surname>
<given-names>D.</given-names>
</name>
<name><surname>Mourão-Sá</surname>
<given-names>D.</given-names>
</name>
<name><surname>Joffre</surname>
<given-names>O.P.</given-names>
</name>
<name><surname>Schulz</surname>
<given-names>O.</given-names>
</name>
<name><surname>Rogers</surname>
<given-names>N.C.</given-names>
</name>
<name><surname>Pennington</surname>
<given-names>D.J.</given-names>
</name>
<name><surname>Carlyle</surname>
<given-names>J.R.</given-names>
</name>
<name><surname>Reis Sousa</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin</article-title>
<source>J. Clin. Investig.</source>
<year>2008</year>
<volume>118</volume>
<fpage>2098</fpage>
<lpage>2110</lpage>
<pub-id pub-id-type="doi">10.1172/JCI34584</pub-id>
<pub-id pub-id-type="pmid">18497879</pub-id>
</element-citation>
</ref>
<ref id="B140-pharmaceutics-12-00153"><label>140.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Caminschi</surname>
<given-names>I.</given-names>
</name>
<name><surname>Proietto</surname>
<given-names>A.I.</given-names>
</name>
<name><surname>Ahmet</surname>
<given-names>F.</given-names>
</name>
<name><surname>Kitsoulis</surname>
<given-names>S.</given-names>
</name>
<name><surname>Shin The</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lo</surname>
<given-names>J.C.</given-names>
</name>
<name><surname>Rizzitelli</surname>
<given-names>A.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Vremec</surname>
<given-names>D.</given-names>
</name>
<name><surname>van Dommelen</surname>
<given-names>S.L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The dendritic cell subtype- restricted C-type lectin Clec9A is a target for vaccine enhancement</article-title>
<source>Blood</source>
<year>2008</year>
<volume>112</volume>
<fpage>3264</fpage>
<lpage>3273</lpage>
<pub-id pub-id-type="doi">10.1182/blood-2008-05-155176</pub-id>
<pub-id pub-id-type="pmid">18669894</pub-id>
</element-citation>
</ref>
<ref id="B141-pharmaceutics-12-00153"><label>141.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Martinez-Pomares</surname>
<given-names>L.</given-names>
</name>
</person-group>
<article-title>The mannose receptor</article-title>
<source>J. Leukoc. Biol.</source>
<year>2012</year>
<volume>92</volume>
<fpage>1177</fpage>
<lpage>1186</lpage>
<pub-id pub-id-type="doi">10.1189/jlb.0512231</pub-id>
<pub-id pub-id-type="pmid">22966131</pub-id>
</element-citation>
</ref>
<ref id="B142-pharmaceutics-12-00153"><label>142.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hosokawa</surname>
<given-names>N.</given-names>
</name>
<name><surname>Kamiya</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Kamiya</surname>
<given-names>D.</given-names>
</name>
<name><surname>Kato</surname>
<given-names>K.</given-names>
</name>
<name><surname>Nagata</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans</article-title>
<source>J. Biol. Chem.</source>
<year>2009</year>
<volume>284</volume>
<fpage>17061</fpage>
<lpage>17068</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.M809725200</pub-id>
<pub-id pub-id-type="pmid">19346256</pub-id>
</element-citation>
</ref>
<ref id="B143-pharmaceutics-12-00153"><label>143.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kreer</surname>
<given-names>C.</given-names>
</name>
<name><surname>Kuepper</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Zehner</surname>
<given-names>M.</given-names>
</name>
<name><surname>Quast</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kolanus</surname>
<given-names>W.</given-names>
</name>
<name><surname>Schumak</surname>
<given-names>B.</given-names>
</name>
<name><surname>Burgdorf</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>N-glycosylation converts non-glycoproteins into mannose receptor ligands and reveals antigen-specific T cell responses in vivo</article-title>
<source>Oncotarget</source>
<year>2017</year>
<volume>8</volume>
<fpage>6857</fpage>
<lpage>6872</lpage>
<pub-id pub-id-type="doi">10.18632/oncotarget.14314</pub-id>
<pub-id pub-id-type="pmid">28036287</pub-id>
</element-citation>
</ref>
<ref id="B144-pharmaceutics-12-00153"><label>144.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Friedlander</surname>
<given-names>R.</given-names>
</name>
<name><surname>Jarosch</surname>
<given-names>E.</given-names>
</name>
<name><surname>Urban</surname>
<given-names>J.</given-names>
</name>
<name><surname>Volkwein</surname>
<given-names>C.</given-names>
</name>
<name><surname>Sommer</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>A regulatory link between ER-associated protein degradation and the unfolded-protein response</article-title>
<source>Nat. Cell Biol.</source>
<year>2000</year>
<volume>2</volume>
<fpage>379</fpage>
<lpage>384</lpage>
<pub-id pub-id-type="doi">10.1038/35017001</pub-id>
<pub-id pub-id-type="pmid">10878801</pub-id>
</element-citation>
</ref>
<ref id="B145-pharmaceutics-12-00153"><label>145.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Greenfield</surname>
<given-names>J.J.</given-names>
</name>
<name><surname>High</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment</article-title>
<source>J. Cell Sci.</source>
<year>1999</year>
<volume>112</volume>
<fpage>1477</fpage>
<lpage>1486</lpage>
<pub-id pub-id-type="pmid">10212142</pub-id>
</element-citation>
</ref>
<ref id="B146-pharmaceutics-12-00153"><label>146.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kalies</surname>
<given-names>K.U.</given-names>
</name>
<name><surname>Rapoport</surname>
<given-names>T.A.</given-names>
</name>
<name><surname>Hartmann</surname>
<given-names>E.</given-names>
</name>
</person-group>
<article-title>The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation</article-title>
<source>J. Cell Biol.</source>
<year>1998</year>
<volume>141</volume>
<fpage>887</fpage>
<lpage>894</lpage>
<pub-id pub-id-type="doi">10.1083/jcb.141.4.887</pub-id>
<pub-id pub-id-type="pmid">9585408</pub-id>
</element-citation>
</ref>
<ref id="B147-pharmaceutics-12-00153"><label>147.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Koopmann</surname>
<given-names>J.O.</given-names>
</name>
<name><surname>Albring</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hüter</surname>
<given-names>E.</given-names>
</name>
<name><surname>Bulbuc</surname>
<given-names>N.</given-names>
</name>
<name><surname>Spee</surname>
<given-names>P.</given-names>
</name>
<name><surname>Neefjes</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hämmerling</surname>
<given-names>G.J.</given-names>
</name>
<name><surname>Momburg</surname>
<given-names>F.</given-names>
</name>
</person-group>
<article-title>Export of antigenic peptides from the endoplasmic reticulum intersects with retro-grade protein translocation through the Sec61p channel</article-title>
<source>Immunity</source>
<year>2000</year>
<volume>13</volume>
<fpage>117</fpage>
<lpage>127</lpage>
<pub-id pub-id-type="doi">10.1016/S1074-7613(00)00013-3</pub-id>
<pub-id pub-id-type="pmid">10933400</pub-id>
</element-citation>
</ref>
<ref id="B148-pharmaceutics-12-00153"><label>148.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wirth</surname>
<given-names>A.</given-names>
</name>
<name><surname>Jung</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bies</surname>
<given-names>C.</given-names>
</name>
<name><surname>Frien</surname>
<given-names>M.</given-names>
</name>
<name><surname>Tyedmers</surname>
<given-names>J.</given-names>
</name>
<name><surname>Zimmermann</surname>
<given-names>R.</given-names>
</name>
<name><surname>Wagner</surname>
<given-names>R.</given-names>
</name>
</person-group>
<article-title>The Sec61p complex is a dynamic precursor activated channel</article-title>
<source>Mol. Cell</source>
<year>2003</year>
<volume>12</volume>
<fpage>261</fpage>
<lpage>268</lpage>
<pub-id pub-id-type="doi">10.1016/S1097-2765(03)00283-1</pub-id>
<pub-id pub-id-type="pmid">12887911</pub-id>
</element-citation>
</ref>
<ref id="B149-pharmaceutics-12-00153"><label>149.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schäuble</surname>
<given-names>N.</given-names>
</name>
<name><surname>Cavalié</surname>
<given-names>A.</given-names>
</name>
<name><surname>Zimmermann</surname>
<given-names>R.</given-names>
</name>
<name><surname>Jung</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Interaction of <italic>Pseudomonas aeruginosa</italic>
Exotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmic reticulum</article-title>
<source>Channels</source>
<year>2014</year>
<volume>8</volume>
<fpage>76</fpage>
<lpage>83</lpage>
<pub-id pub-id-type="doi">10.4161/chan.26526</pub-id>
<pub-id pub-id-type="pmid">24088629</pub-id>
</element-citation>
</ref>
<ref id="B150-pharmaceutics-12-00153"><label>150.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ackerman</surname>
<given-names>A.L.</given-names>
</name>
<name><surname>Giodini</surname>
<given-names>A.</given-names>
</name>
<name><surname>Cresswell</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells</article-title>
<source>Immunity</source>
<year>2006</year>
<volume>25</volume>
<fpage>607</fpage>
<lpage>617</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2006.08.017</pub-id>
<pub-id pub-id-type="pmid">17027300</pub-id>
</element-citation>
</ref>
<ref id="B151-pharmaceutics-12-00153"><label>151.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Romisch</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>A Case for Sec61 Channel Involvement in ERAD</article-title>
<source>Trends Biochem. Sci.</source>
<year>2017</year>
<volume>42</volume>
<fpage>171</fpage>
<lpage>179</lpage>
<pub-id pub-id-type="doi">10.1016/j.tibs.2016.10.005</pub-id>
<pub-id pub-id-type="pmid">27932072</pub-id>
</element-citation>
</ref>
<ref id="B152-pharmaceutics-12-00153"><label>152.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>You</surname>
<given-names>X.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>D.D.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>D.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Gao</surname>
<given-names>F.G.</given-names>
</name>
</person-group>
<article-title>PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-kappaB Inactivation</article-title>
<source>J. Immunol. Res.</source>
<year>2018</year>
<volume>2018</volume>
<fpage>5070573</fpage>
<pub-id pub-id-type="doi">10.1155/2018/5070573</pub-id>
<pub-id pub-id-type="pmid">30069488</pub-id>
</element-citation>
</ref>
<ref id="B153-pharmaceutics-12-00153"><label>153.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burgdorf</surname>
<given-names>S.</given-names>
</name>
<name><surname>Leister</surname>
<given-names>P.</given-names>
</name>
<name><surname>Scheidtmann</surname>
<given-names>K.H.</given-names>
</name>
</person-group>
<article-title>TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination</article-title>
<source>J. Biol. Chem.</source>
<year>2004</year>
<volume>279</volume>
<fpage>17524</fpage>
<lpage>17534</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.M313703200</pub-id>
<pub-id pub-id-type="pmid">14761944</pub-id>
</element-citation>
</ref>
<ref id="B154-pharmaceutics-12-00153"><label>154.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Imai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kato</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Kajiwara</surname>
<given-names>C.</given-names>
</name>
<name><surname>Mizukami</surname>
<given-names>S.</given-names>
</name>
<name><surname>Ishige</surname>
<given-names>I.</given-names>
</name>
<name><surname>Ichiyanagi</surname>
<given-names>T.</given-names>
</name>
<name><surname>Hikida</surname>
<given-names>M.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>J.Y.</given-names>
</name>
<name><surname>Udono</surname>
<given-names>H.</given-names>
</name>
</person-group>
<article-title>Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2011</year>
<volume>108</volume>
<fpage>16363</fpage>
<lpage>16368</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.1108372108</pub-id>
<pub-id pub-id-type="pmid">21930907</pub-id>
</element-citation>
</ref>
<ref id="B155-pharmaceutics-12-00153"><label>155.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Li</surname>
<given-names>L.</given-names>
</name>
<name><surname>Ye</surname>
<given-names>Y.</given-names>
</name>
</person-group>
<article-title>Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3</article-title>
<source>J. Cell Biol.</source>
<year>2006</year>
<volume>174</volume>
<fpage>963</fpage>
<lpage>971</lpage>
<pub-id pub-id-type="doi">10.1083/jcb.200605100</pub-id>
<pub-id pub-id-type="pmid">17000876</pub-id>
</element-citation>
</ref>
<ref id="B156-pharmaceutics-12-00153"><label>156.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reits</surname>
<given-names>E.</given-names>
</name>
<name><surname>Neijssen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Herberts</surname>
<given-names>C.</given-names>
</name>
<name><surname>Benckhuijsen</surname>
<given-names>W.</given-names>
</name>
<name><surname>Janssen</surname>
<given-names>L.</given-names>
</name>
<name><surname>Drijfhout</surname>
<given-names>J.W.</given-names>
</name>
<name><surname>Neefjes</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation</article-title>
<source>Immunity</source>
<year>2004</year>
<volume>20</volume>
<fpage>495</fpage>
<lpage>506</lpage>
<pub-id pub-id-type="doi">10.1016/S1074-7613(04)00074-3</pub-id>
<pub-id pub-id-type="pmid">15084277</pub-id>
</element-citation>
</ref>
<ref id="B157-pharmaceutics-12-00153"><label>157.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Burgdorf</surname>
<given-names>S.</given-names>
</name>
<name><surname>Schölz</surname>
<given-names>C.</given-names>
</name>
<name><surname>Kautz</surname>
<given-names>A.</given-names>
</name>
<name><surname>Tampé</surname>
<given-names>R.</given-names>
</name>
<name><surname>Kurts</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation</article-title>
<source>Nat. Immunol.</source>
<year>2008</year>
<volume>9</volume>
<fpage>558</fpage>
<lpage>566</lpage>
<pub-id pub-id-type="doi">10.1038/ni.1601</pub-id>
<pub-id pub-id-type="pmid">18376402</pub-id>
</element-citation>
</ref>
<ref id="B158-pharmaceutics-12-00153"><label>158.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saveanu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Carroll</surname>
<given-names>O.</given-names>
</name>
<name><surname>Hassainya</surname>
<given-names>Y.</given-names>
</name>
<name><surname>van Endert</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Complexity, contradictions, and conundrums: Studying post-proteasomal proteolysis in HLA class I antigen presentation</article-title>
<source>Immunol. Rev.</source>
<year>2005</year>
<volume>207</volume>
<fpage>42</fpage>
<lpage>59</lpage>
<pub-id pub-id-type="doi">10.1111/j.0105-2896.2005.00313.x</pub-id>
<pub-id pub-id-type="pmid">16181326</pub-id>
</element-citation>
</ref>
<ref id="B159-pharmaceutics-12-00153"><label>159.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saveanu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Carroll</surname>
<given-names>O.</given-names>
</name>
<name><surname>Weimershaus</surname>
<given-names>M.</given-names>
</name>
<name><surname>Guermonprez</surname>
<given-names>P.</given-names>
</name>
<name><surname>Firat</surname>
<given-names>E.</given-names>
</name>
<name><surname>Lindo</surname>
<given-names>V.</given-names>
</name>
<name><surname>Greer</surname>
<given-names>F.</given-names>
</name>
<name><surname>Davoust</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kratzer</surname>
<given-names>R.</given-names>
</name>
<name><surname>Keller</surname>
<given-names>S.R.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>IRAP identifies an endosomal compartment required for MHC class I cross-presentation</article-title>
<source>Science</source>
<year>2009</year>
<volume>325</volume>
<fpage>213</fpage>
<lpage>217</lpage>
<pub-id pub-id-type="doi">10.1126/science.1172845</pub-id>
<pub-id pub-id-type="pmid">19498108</pub-id>
</element-citation>
</ref>
<ref id="B160-pharmaceutics-12-00153"><label>160.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Subtil</surname>
<given-names>A.</given-names>
</name>
<name><surname>Lampson</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Keller</surname>
<given-names>S.R.</given-names>
</name>
<name><surname>McGraw</surname>
<given-names>T.E.</given-names>
</name>
</person-group>
<article-title>Characterization of the insulin-regulated endocytic recycling mechanism in 3T3-L1 adipocytes using a novel reporter molecule</article-title>
<source>J. Biol. Chem.</source>
<year>2000</year>
<volume>275</volume>
<fpage>4787</fpage>
<lpage>4795</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.275.7.4787</pub-id>
<pub-id pub-id-type="pmid">10671512</pub-id>
</element-citation>
</ref>
<ref id="B161-pharmaceutics-12-00153"><label>161.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Firat</surname>
<given-names>E.</given-names>
</name>
<name><surname>Saveanu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Aichele</surname>
<given-names>P.</given-names>
</name>
<name><surname>Staeheli</surname>
<given-names>P.</given-names>
</name>
<name><surname>Huai</surname>
<given-names>J.</given-names>
</name>
<name><surname>Gaedicke</surname>
<given-names>S.</given-names>
</name>
<name><surname>Nil</surname>
<given-names>A.</given-names>
</name>
<name><surname>Besin</surname>
<given-names>G.</given-names>
</name>
<name><surname>Kanzler</surname>
<given-names>B.</given-names>
</name>
<name><surname>van Endert</surname>
<given-names>P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation</article-title>
<source>J. Immunol.</source>
<year>2007</year>
<volume>178</volume>
<fpage>2241</fpage>
<lpage>2248</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.178.4.2241</pub-id>
<pub-id pub-id-type="pmid">17277129</pub-id>
</element-citation>
</ref>
<ref id="B162-pharmaceutics-12-00153"><label>162.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zagorac</surname>
<given-names>G.B.</given-names>
</name>
<name><surname>Mahmutefendić</surname>
<given-names>H.</given-names>
</name>
<name><surname>Tomaš</surname>
<given-names>M.I.</given-names>
</name>
<name><surname>Kučić</surname>
<given-names>N.</given-names>
</name>
<name><surname>Le Bouteiller</surname>
<given-names>P.</given-names>
</name>
<name><surname>Lučin</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Early endosomal rerouting of major histocompatibility class I conformers</article-title>
<source>J. Cell Physiol.</source>
<year>2012</year>
<volume>227</volume>
<fpage>2953</fpage>
<lpage>2964</lpage>
<pub-id pub-id-type="doi">10.1002/jcp.23042</pub-id>
<pub-id pub-id-type="pmid">21959869</pub-id>
</element-citation>
</ref>
<ref id="B163-pharmaceutics-12-00153"><label>163.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ma</surname>
<given-names>W.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Vigneron</surname>
<given-names>N.</given-names>
</name>
<name><surname>Stroobant</surname>
<given-names>V.</given-names>
</name>
<name><surname>Thielemans</surname>
<given-names>K.</given-names>
</name>
<name><surname>van der Bruggen</surname>
<given-names>P.</given-names>
</name>
<name><surname>Van den Eynde</surname>
<given-names>B.J.</given-names>
</name>
</person-group>
<article-title>Long-peptide cross-presentation by human dendritic cells occurs in vacuoles by peptide exchange on nascent MHC class I molecules</article-title>
<source>J. Immunol.</source>
<year>2016</year>
<volume>196</volume>
<fpage>1711</fpage>
<lpage>1720</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.1501574</pub-id>
<pub-id pub-id-type="pmid">26792804</pub-id>
</element-citation>
</ref>
<ref id="B164-pharmaceutics-12-00153"><label>164.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Osorio</surname>
<given-names>F.</given-names>
</name>
<name><surname>Tavernier</surname>
<given-names>S.J.</given-names>
</name>
<name><surname>Hoffmann</surname>
<given-names>E.</given-names>
</name>
<name><surname>Saeys</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Martens</surname>
<given-names>L.</given-names>
</name>
<name><surname>Vetters</surname>
<given-names>J.</given-names>
</name>
<name><surname>Delrue</surname>
<given-names>I.</given-names>
</name>
<name><surname>De Rycke</surname>
<given-names>R.</given-names>
</name>
<name><surname>Parthoens</surname>
<given-names>E.</given-names>
</name>
<name><surname>Pouliot</surname>
<given-names>P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The unfolded-protein-response sensor IRE-1alpha regulates the function of CD8alpha+ dendritic cells</article-title>
<source>Nat. Immunol.</source>
<year>2014</year>
<volume>15</volume>
<fpage>248</fpage>
<lpage>257</lpage>
<pub-id pub-id-type="doi">10.1038/ni.2808</pub-id>
<pub-id pub-id-type="pmid">24441789</pub-id>
</element-citation>
</ref>
<ref id="B165-pharmaceutics-12-00153"><label>165.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cubillos-Ruiz</surname>
<given-names>J.R.</given-names>
</name>
<name><surname>Silberman</surname>
<given-names>P.C.</given-names>
</name>
<name><surname>Rutkowski</surname>
<given-names>M.R.</given-names>
</name>
<name><surname>Chopra</surname>
<given-names>S.</given-names>
</name>
<name><surname>Perales-Puchalt</surname>
<given-names>A.</given-names>
</name>
<name><surname>Song</surname>
<given-names>M.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>S.</given-names>
</name>
<name><surname>Bettigole</surname>
<given-names>S.E.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>D.</given-names>
</name>
<name><surname>Holcomb</surname>
<given-names>K.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis</article-title>
<source>Cell</source>
<year>2015</year>
<volume>161</volume>
<fpage>1527</fpage>
<lpage>1538</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2015.05.025</pub-id>
<pub-id pub-id-type="pmid">26073941</pub-id>
</element-citation>
</ref>
<ref id="B166-pharmaceutics-12-00153"><label>166.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Imai</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Kuba</surname>
<given-names>K.</given-names>
</name>
<name><surname>Neely</surname>
<given-names>G.G.</given-names>
</name>
<name><surname>Yaghubian-Malhami</surname>
<given-names>R.</given-names>
</name>
<name><surname>Perkmann</surname>
<given-names>T.</given-names>
</name>
<name><surname>van Loo</surname>
<given-names>G.</given-names>
</name>
<name><surname>Ermolaeva</surname>
<given-names>M.</given-names>
</name>
<name><surname>Veldhuizen</surname>
<given-names>R.</given-names>
</name>
<name><surname>Leung</surname>
<given-names>Y.H.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>H.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury</article-title>
<source>Cell</source>
<year>2008</year>
<volume>133</volume>
<fpage>235</fpage>
<lpage>249</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2008.02.043</pub-id>
<pub-id pub-id-type="pmid">18423196</pub-id>
</element-citation>
</ref>
<ref id="B167-pharmaceutics-12-00153"><label>167.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mutoh</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ueda</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Peroxidized unsaturated fatty acids stimulate Toll-like receptor 4 signaling in endothelial cells</article-title>
<source>Life Sci.</source>
<year>2013</year>
<volume>92</volume>
<fpage>984</fpage>
<lpage>992</lpage>
<pub-id pub-id-type="doi">10.1016/j.lfs.2013.03.019</pub-id>
<pub-id pub-id-type="pmid">23583568</pub-id>
</element-citation>
</ref>
<ref id="B168-pharmaceutics-12-00153"><label>168.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Retamal-Diaz</surname>
<given-names>A.</given-names>
</name>
<name><surname>Weiss</surname>
<given-names>K.A.</given-names>
</name>
<name><surname>Tognarelli</surname>
<given-names>E.I.</given-names>
</name>
<name><surname>Freire</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bueno</surname>
<given-names>S.M.</given-names>
</name>
<name><surname>Herold</surname>
<given-names>B.C.</given-names>
</name>
<name><surname>Jacobs</surname>
<given-names>W.R.</given-names>
<suffix>Jr.</suffix>
</name>
<name><surname>Gonzalez</surname>
<given-names>P.A.</given-names>
</name>
</person-group>
<article-title>US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation</article-title>
<source>Front. Immunol.</source>
<year>2017</year>
<volume>8</volume>
<fpage>1523</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2017.01523</pub-id>
<pub-id pub-id-type="pmid">29176979</pub-id>
</element-citation>
</ref>
<ref id="B169-pharmaceutics-12-00153"><label>169.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rodvold</surname>
<given-names>J.J.</given-names>
</name>
<name><surname>Mahadevan</surname>
<given-names>N.R.</given-names>
</name>
<name><surname>Zanetti</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Immune modulation by ER stress and inflammation in the tumor microenvironment</article-title>
<source>Cancer Lett.</source>
<year>2015</year>
<volume>380</volume>
<fpage>227</fpage>
<lpage>236</lpage>
<pub-id pub-id-type="doi">10.1016/j.canlet.2015.09.009</pub-id>
<pub-id pub-id-type="pmid">26525580</pub-id>
</element-citation>
</ref>
<ref id="B170-pharmaceutics-12-00153"><label>170.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reading</surname>
<given-names>J.L.</given-names>
</name>
<name><surname>Gálvez-Cancino</surname>
<given-names>F.</given-names>
</name>
<name><surname>Swanton</surname>
<given-names>C.</given-names>
</name>
<name><surname>Lladser</surname>
<given-names>A.</given-names>
</name>
<name><surname>Peggs</surname>
<given-names>K.S.</given-names>
</name>
<name><surname>Quezada</surname>
<given-names>S.A.</given-names>
</name>
</person-group>
<article-title>The function and dysfunction of memory CD8(+) T cells in tumor immunity</article-title>
<source>Immunol. Rev.</source>
<year>2018</year>
<volume>283</volume>
<fpage>194</fpage>
<lpage>212</lpage>
<pub-id pub-id-type="doi">10.1111/imr.12657</pub-id>
<pub-id pub-id-type="pmid">29664561</pub-id>
</element-citation>
</ref>
<ref id="B171-pharmaceutics-12-00153"><label>171.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gebhardt</surname>
<given-names>T.</given-names>
</name>
<name><surname>Palendira</surname>
<given-names>U.</given-names>
</name>
<name><surname>Tscharke</surname>
<given-names>D.C.</given-names>
</name>
<name><surname>Bedoui</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance</article-title>
<source>Immunol. Rev.</source>
<year>2018</year>
<volume>283</volume>
<fpage>54</fpage>
<lpage>76</lpage>
<pub-id pub-id-type="doi">10.1111/imr.12650</pub-id>
<pub-id pub-id-type="pmid">29664571</pub-id>
</element-citation>
</ref>
<ref id="B172-pharmaceutics-12-00153"><label>172.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Akira</surname>
<given-names>S.</given-names>
</name>
<name><surname>Uematsu</surname>
<given-names>S.</given-names>
</name>
<name><surname>Takeuchi</surname>
<given-names>O.</given-names>
</name>
</person-group>
<article-title>Pathogen recognition and innate immunity</article-title>
<source>Cell</source>
<year>2006</year>
<volume>124</volume>
<fpage>783</fpage>
<lpage>801</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2006.02.015</pub-id>
<pub-id pub-id-type="pmid">16497588</pub-id>
</element-citation>
</ref>
<ref id="B173-pharmaceutics-12-00153"><label>173.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Medzhitov</surname>
<given-names>R.</given-names>
</name>
</person-group>
<article-title>Toll-like receptors and innate immunity</article-title>
<source>Nat. Rev. Immunol.</source>
<year>2001</year>
<volume>1</volume>
<fpage>135</fpage>
<lpage>145</lpage>
<pub-id pub-id-type="doi">10.1038/35100529</pub-id>
<pub-id pub-id-type="pmid">11905821</pub-id>
</element-citation>
</ref>
<ref id="B174-pharmaceutics-12-00153"><label>174.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reverendo</surname>
<given-names>M.</given-names>
</name>
<name><surname>Mendes</surname>
<given-names>A.</given-names>
</name>
<name><surname>Arguello</surname>
<given-names>R.J.</given-names>
</name>
<name><surname>Gatti</surname>
<given-names>E.</given-names>
</name>
<name><surname>Pierre</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>At the crossway of ER-stress and proinflammatory responses</article-title>
<source>FEBS J.</source>
<year>2019</year>
<volume>286</volume>
<fpage>297</fpage>
<lpage>310</lpage>
<pub-id pub-id-type="doi">10.1111/febs.14391</pub-id>
<pub-id pub-id-type="pmid">29360216</pub-id>
</element-citation>
</ref>
<ref id="B175-pharmaceutics-12-00153"><label>175.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pizzurro</surname>
<given-names>G.A.</given-names>
</name>
<name><surname>Tapia</surname>
<given-names>I.J.</given-names>
</name>
<name><surname>Sganga</surname>
<given-names>L.</given-names>
</name>
<name><surname>Podhajcer</surname>
<given-names>O.L.</given-names>
</name>
<name><surname>Mordoh</surname>
<given-names>J.</given-names>
</name>
<name><surname>Barrio</surname>
<given-names>M.M.</given-names>
</name>
</person-group>
<article-title>Cytokine-enhanced maturation and migration to the lymph nodes of a human dying melanoma cell-loaded dendritic cell vaccine</article-title>
<source>Cancer Immunol. Immunother.</source>
<year>2015</year>
<volume>64</volume>
<fpage>1393</fpage>
<lpage>1406</lpage>
<pub-id pub-id-type="doi">10.1007/s00262-015-1743-z</pub-id>
<pub-id pub-id-type="pmid">26197849</pub-id>
</element-citation>
</ref>
<ref id="B176-pharmaceutics-12-00153"><label>176.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alloatti</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kotsias</surname>
<given-names>F.</given-names>
</name>
<name><surname>Magalhaes</surname>
<given-names>J.G.</given-names>
</name>
<name><surname>Amigorena</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Dendritic cell maturation and cross-presentation: Timing matters!</article-title>
<source>Immunol. Rev.</source>
<year>2016</year>
<volume>272</volume>
<fpage>97</fpage>
<lpage>108</lpage>
<pub-id pub-id-type="doi">10.1111/imr.12432</pub-id>
<pub-id pub-id-type="pmid">27319345</pub-id>
</element-citation>
</ref>
<ref id="B177-pharmaceutics-12-00153"><label>177.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chi</surname>
<given-names>H.</given-names>
</name>
<name><surname>Li</surname>
<given-names>C.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>F.S.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>L.</given-names>
</name>
<name><surname>Ng</surname>
<given-names>T.B.</given-names>
</name>
<name><surname>Jin</surname>
<given-names>G.</given-names>
</name>
<name><surname>Sha</surname>
<given-names>O.</given-names>
</name>
</person-group>
<article-title>Anti-tumor Activity of Toll-Like Receptor 7 Agonists</article-title>
<source>Front. Pharmacol.</source>
<year>2017</year>
<volume>8</volume>
<fpage>304</fpage>
<pub-id pub-id-type="doi">10.3389/fphar.2017.00304</pub-id>
<pub-id pub-id-type="pmid">28620298</pub-id>
</element-citation>
</ref>
<ref id="B178-pharmaceutics-12-00153"><label>178.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vacchelli</surname>
<given-names>E.</given-names>
</name>
<name><surname>Eggermont</surname>
<given-names>A.</given-names>
</name>
<name><surname>Sautès-Fridman</surname>
<given-names>C.</given-names>
</name>
<name><surname>Galon</surname>
<given-names>J.</given-names>
</name>
<name><surname>Zitvogel</surname>
<given-names>L.</given-names>
</name>
<name><surname>Kroemer</surname>
<given-names>G.</given-names>
</name>
<name><surname>Galluzzi</surname>
<given-names>L.</given-names>
</name>
</person-group>
<article-title>Trial Watch: Toll-like receptor agonists for cancer therapy</article-title>
<source>Oncoimmunology</source>
<year>2013</year>
<volume>8</volume>
<fpage>e25238</fpage>
<pub-id pub-id-type="doi">10.4161/onci.25238</pub-id>
</element-citation>
</ref>
<ref id="B179-pharmaceutics-12-00153"><label>179.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bourque</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hawiger</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells</article-title>
<source>Crit. Rev. Immunol.</source>
<year>2018</year>
<volume>38</volume>
<fpage>379</fpage>
<lpage>401</lpage>
<pub-id pub-id-type="doi">10.1615/CritRevImmunol.2018026790</pub-id>
<pub-id pub-id-type="pmid">30792568</pub-id>
</element-citation>
</ref>
<ref id="B180-pharmaceutics-12-00153"><label>180.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weimershaus</surname>
<given-names>M.</given-names>
</name>
<name><surname>Mauvais</surname>
<given-names>F.X.</given-names>
</name>
<name><surname>Saveanu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Adiko</surname>
<given-names>C.</given-names>
</name>
<name><surname>Babdor</surname>
<given-names>J.</given-names>
</name>
<name><surname>Abramova</surname>
<given-names>A.</given-names>
</name>
<name><surname>Montealegre</surname>
<given-names>S.</given-names>
</name>
<name><surname>Lawand</surname>
<given-names>M.</given-names>
</name>
<name><surname>Evnouchidou</surname>
<given-names>I.</given-names>
</name>
<name><surname>Huber</surname>
<given-names>K.J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation</article-title>
<source>Cell Rep.</source>
<year>2018</year>
<volume>24</volume>
<fpage>3568</fpage>
<lpage>3581</lpage>
<pub-id pub-id-type="doi">10.1016/j.celrep.2018.08.041</pub-id>
<pub-id pub-id-type="pmid">30257216</pub-id>
</element-citation>
</ref>
<ref id="B181-pharmaceutics-12-00153"><label>181.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pauwels</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Hartlova</surname>
<given-names>A.</given-names>
</name>
<name><surname>Peltier</surname>
<given-names>J.</given-names>
</name>
<name><surname>Driege</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Baudelet</surname>
<given-names>G.</given-names>
</name>
<name><surname>Brodin</surname>
<given-names>P.</given-names>
</name>
<name><surname>Trost</surname>
<given-names>M.</given-names>
</name>
<name><surname>Beyaert</surname>
<given-names>R.</given-names>
</name>
<name><surname>Hoffmann</surname>
<given-names>E.</given-names>
</name>
</person-group>
<article-title>Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation</article-title>
<source>Mol. Cell. Proteom.</source>
<year>2019</year>
<volume>18</volume>
<fpage>909</fpage>
<lpage>922</lpage>
<pub-id pub-id-type="doi">10.1074/mcp.RA119.001316</pub-id>
<pub-id pub-id-type="pmid">30808727</pub-id>
</element-citation>
</ref>
<ref id="B182-pharmaceutics-12-00153"><label>182.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Blander</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Medzhitov</surname>
<given-names>R.</given-names>
</name>
</person-group>
<article-title>Toll-dependent selection of microbial antigens for presentation by dendritic cells</article-title>
<source>Nature</source>
<year>2006</year>
<volume>440</volume>
<fpage>808</fpage>
<lpage>812</lpage>
<pub-id pub-id-type="doi">10.1038/nature04596</pub-id>
<pub-id pub-id-type="pmid">16489357</pub-id>
</element-citation>
</ref>
<ref id="B183-pharmaceutics-12-00153"><label>183.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Corridoni</surname>
<given-names>D.</given-names>
</name>
<name><surname>Shiraishi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Chapman</surname>
<given-names>T.</given-names>
</name>
<name><surname>Steevels</surname>
<given-names>T.</given-names>
</name>
<name><surname>Muraro</surname>
<given-names>D.</given-names>
</name>
<name><surname>Thezenas</surname>
<given-names>M.L.</given-names>
</name>
<name><surname>Prota</surname>
<given-names>G.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>J.L.</given-names>
</name>
<name><surname>Gileadi</surname>
<given-names>U.</given-names>
</name>
<name><surname>Ternette</surname>
<given-names>N.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses</article-title>
<source>Front. Immunol.</source>
<year>2019</year>
<volume>10</volume>
<fpage>958</fpage>
<pub-id pub-id-type="doi">10.3389/fimmu.2019.00958</pub-id>
<pub-id pub-id-type="pmid">31114588</pub-id>
</element-citation>
</ref>
<ref id="B184-pharmaceutics-12-00153"><label>184.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jelinek</surname>
<given-names>I.</given-names>
</name>
<name><surname>Leonard</surname>
<given-names>J.N.</given-names>
</name>
<name><surname>Price</surname>
<given-names>G.E.</given-names>
</name>
<name><surname>Brown</surname>
<given-names>K.N.</given-names>
</name>
<name><surname>Meyer-Manlapat</surname>
<given-names>A.</given-names>
</name>
<name><surname>Goldsmith</surname>
<given-names>P.K.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Venzon</surname>
<given-names>D.</given-names>
</name>
<name><surname>Epstein</surname>
<given-names>S.L.</given-names>
</name>
<name><surname>Segal</surname>
<given-names>D.M.</given-names>
</name>
</person-group>
<article-title>TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection</article-title>
<source>J. Immunol.</source>
<year>2011</year>
<volume>186</volume>
<fpage>2422</fpage>
<lpage>2429</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.1002845</pub-id>
<pub-id pub-id-type="pmid">21242525</pub-id>
</element-citation>
</ref>
<ref id="B185-pharmaceutics-12-00153"><label>185.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Asano</surname>
<given-names>J.</given-names>
</name>
<name><surname>Tada</surname>
<given-names>H.</given-names>
</name>
<name><surname>Onai</surname>
<given-names>N.</given-names>
</name>
<name><surname>Sato</surname>
<given-names>T.</given-names>
</name>
<name><surname>Horie</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Fujimoto</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Fukase</surname>
<given-names>K.</given-names>
</name>
<name><surname>Suzuki</surname>
<given-names>A.</given-names>
</name>
<name><surname>Mak</surname>
<given-names>T.W.</given-names>
</name>
<name><surname>Ohteki</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo</article-title>
<source>J. Immunol.</source>
<year>2010</year>
<volume>184</volume>
<fpage>736</fpage>
<lpage>745</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.0900726</pub-id>
<pub-id pub-id-type="pmid">20008287</pub-id>
</element-citation>
</ref>
<ref id="B186-pharmaceutics-12-00153"><label>186.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Visvikis</surname>
<given-names>O.</given-names>
</name>
<name><surname>Ihuegbu</surname>
<given-names>N.</given-names>
</name>
<name><surname>Labed</surname>
<given-names>S.A.</given-names>
</name>
<name><surname>Luhachack</surname>
<given-names>L.G.</given-names>
</name>
<name><surname>Alves</surname>
<given-names>A.F.</given-names>
</name>
<name><surname>Wollenberg</surname>
<given-names>A.C.</given-names>
</name>
<name><surname>Stuart</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Stormo</surname>
<given-names>G.D.</given-names>
</name>
<name><surname>Irazoqui</surname>
<given-names>J.E.</given-names>
</name>
</person-group>
<article-title>Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes</article-title>
<source>Immunity</source>
<year>2014</year>
<volume>40</volume>
<fpage>896</fpage>
<lpage>909</lpage>
<pub-id pub-id-type="doi">10.1016/j.immuni.2014.05.002</pub-id>
<pub-id pub-id-type="pmid">24882217</pub-id>
</element-citation>
</ref>
<ref id="B187-pharmaceutics-12-00153"><label>187.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ma</surname>
<given-names>J.</given-names>
</name>
<name><surname>Wei</surname>
<given-names>K.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>H.</given-names>
</name>
<name><surname>Tang</surname>
<given-names>K.</given-names>
</name>
<name><surname>Li</surname>
<given-names>F.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>T.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>P.</given-names>
</name>
<name><surname>Yu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Sun</surname>
<given-names>W.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Mechanisms by which dendritic cells present tumor microparticle antigens to CD8+ T cells</article-title>
<source>Cancer Immunol. Res.</source>
<year>2018</year>
<volume>9</volume>
<fpage>1057</fpage>
<lpage>1068</lpage>
<pub-id pub-id-type="doi">10.1158/2326-6066.CIR-17-0716</pub-id>
</element-citation>
</ref>
<ref id="B188-pharmaceutics-12-00153"><label>188.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Faure-André</surname>
<given-names>G.</given-names>
</name>
<name><surname>Vargas</surname>
<given-names>P.</given-names>
</name>
<name><surname>Yuseff</surname>
<given-names>M.</given-names>
</name>
<name><surname>Heuzé</surname>
<given-names>M.</given-names>
</name>
<name><surname>Diaz</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lankar</surname>
<given-names>D.</given-names>
</name>
<name><surname>Steri</surname>
<given-names>V.</given-names>
</name>
<name><surname>Manry</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hugues</surname>
<given-names>S.</given-names>
</name>
<name><surname>Vascotto</surname>
<given-names>F.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain</article-title>
<source>Science</source>
<year>2008</year>
<volume>322</volume>
<fpage>1705</fpage>
<lpage>1710</lpage>
<pub-id pub-id-type="doi">10.1126/science.1159894</pub-id>
<pub-id pub-id-type="pmid">19074353</pub-id>
</element-citation>
</ref>
<ref id="B189-pharmaceutics-12-00153"><label>189.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vargas</surname>
<given-names>P.</given-names>
</name>
<name><surname>Maiuri</surname>
<given-names>P.</given-names>
</name>
<name><surname>Bretou</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sáez</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>Pierobon</surname>
<given-names>P.</given-names>
</name>
<name><surname>Maurin</surname>
<given-names>M.</given-names>
</name>
<name><surname>Chabaud</surname>
<given-names>M.</given-names>
</name>
<name><surname>Lankar</surname>
<given-names>D.</given-names>
</name>
<name><surname>Obino</surname>
<given-names>D.</given-names>
</name>
<name><surname>Terriac</surname>
<given-names>E.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells</article-title>
<source>Nat. Cell Biol.</source>
<year>2015</year>
<volume>18</volume>
<fpage>43</fpage>
<lpage>53</lpage>
<pub-id pub-id-type="doi">10.1038/ncb3284</pub-id>
<pub-id pub-id-type="pmid">26641718</pub-id>
</element-citation>
</ref>
<ref id="B190-pharmaceutics-12-00153"><label>190.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dalod</surname>
<given-names>M.</given-names>
</name>
<name><surname>Chelbi</surname>
<given-names>R.</given-names>
</name>
<name><surname>Malissen</surname>
<given-names>B.</given-names>
</name>
<name><surname>Lawrence</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>Dendritic cell maturation: Functional specialization through signaling specificity and transcriptional programming</article-title>
<source>EMBO J.</source>
<year>2014</year>
<volume>33</volume>
<fpage>1104</fpage>
<lpage>1116</lpage>
<pub-id pub-id-type="doi">10.1002/embj.201488027</pub-id>
<pub-id pub-id-type="pmid">24737868</pub-id>
</element-citation>
</ref>
<ref id="B191-pharmaceutics-12-00153"><label>191.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Galluzzi</surname>
<given-names>L.</given-names>
</name>
<name><surname>Senovilla</surname>
<given-names>L.</given-names>
</name>
<name><surname>Vacchelli</surname>
<given-names>E.</given-names>
</name>
<name><surname>Eggermont</surname>
<given-names>A.</given-names>
</name>
<name><surname>Fridman</surname>
<given-names>W.H.</given-names>
</name>
<name><surname>Galon</surname>
<given-names>J.</given-names>
</name>
<name><surname>Sautès-Fridman</surname>
<given-names>C.</given-names>
</name>
<name><surname>Tartour</surname>
<given-names>E.</given-names>
</name>
<name><surname>Zitvogel</surname>
<given-names>L.</given-names>
</name>
<name><surname>Kroemer</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>Trial watch: Dendritic cell-based interventions for cancer therapy</article-title>
<source>Oncoimmunology</source>
<year>2012</year>
<volume>1</volume>
<fpage>1111</fpage>
<lpage>1134</lpage>
<pub-id pub-id-type="doi">10.4161/onci.21494</pub-id>
<pub-id pub-id-type="pmid">23170259</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
<floats-group><fig id="pharmaceutics-12-00153-f001" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Maturation of endosomes and cross-presentation (CP). After internalization, exogenous proteins are transported into the endosome. Endocytic compartments without danger signals are acidified, fused with the lysosome, and designated as the proteolytic endosome. Since extracellular proteins without danger signals are self-proteins, those proteins are quickly degraded by the lysosomal proteases, which results in lower CP efficiency. When danger signals are detected by pattern recognition receptors (PRRs) (TLR2, TLR4, Nod1, Nod2), the acidification of endocytic compartments is delayed by the incomplete assembly of V-ATPase and the activation of Nox2, and resulted in the less-proteolytic endosome. The activated Nox2 produces reactive oxygen species (ROS), and ROS promote nonspecific disulfide bond formation to unfold extracellular proteins. As extracellular proteins with danger signals are non-self-proteins, these proteins are recognized by the endoplasmic reticulum (ER)-resident molecular chaperones in the non-classical endosome. Recognition by the ER-resident molecular chaperones accelerates ER-associated degradation (ERAD)-dependent processing of exogenous proteins and results in higher CP efficiency. ROS also activate TFEB, and activated TFEB promotes the maturation of the less-proteolytic endosome with a time difference. The activated TFEB also induces maturation of DCs by initiating the transcription of costimulatory molecules, several cytokines, and chemokines, including IL-1β, IL-6, TNF-α, and CCL5. In contrast to the major histocompatibility complex (MHC) I, MHC II presents antigenic peptides processed by lysosomal protease. MHC II associates with antigenic peptides under acidic conditions in the lysosome.</p>
</caption>
<graphic xlink:href="pharmaceutics-12-00153-g001"></graphic>
</fig>
<fig id="pharmaceutics-12-00153-f002" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Recognition of extracellular proteins in CP. In ERAD-dependent processing, extracellular proteins are unfolded by ROS, resulting in nonspecific disulfide bonds in endocytic compartments. These unfolded extracellular proteins lose their activity and are preferentially recognized as ERAD substrates by ER-resident molecular chaperones, such as BiP, PDI, or ER-degradation enhancing α-mannosidase-like proteins (EDEMs). After recognition, these proteins are retro-transported into the cytosol. In contrast, self-proteins, which are properly folded in these cellular compartments, are not recognized as ERAD substrates and remain in endocytic compartments. After retro-transportation into the cytosol, extracellular proteins are recognized by cytosolic molecular chaperones, such as Hsp70 or Hsp90. After recognition, extracellular proteins are processed by the ubiquitin-proteasome system (UPS) into antigenic peptides and transported into membranous compartments in a transporter associated with antigen processing (TAP)-dependent manner. These two recognition steps indicate that unfolding and recognition of extracellular proteins are critical for CP.</p>
</caption>
<graphic xlink:href="pharmaceutics-12-00153-g002"></graphic>
</fig>
<table-wrap id="pharmaceutics-12-00153-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">pharmaceutics-12-00153-t001_Table 1</object-id>
<label>Table 1</label>
<caption><p>Major dendritic cell (DC) subsets and surface markers [<xref rid="B70-pharmaceutics-12-00153" ref-type="bibr">70</xref>
,<xref rid="B71-pharmaceutics-12-00153" ref-type="bibr">71</xref>
].</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">DC subsets</th>
<th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">Mouse</th>
<th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">Human</th>
</tr>
<tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Surface Marker</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cytokine Profile</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Surface Marker</th>
<th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cytokine Profile</th>
</tr>
</thead>
<tbody><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cDC1</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, MHC II, CD8α, CD103, CD24, XCR1, CLEC9A, CD205</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IL-12 (high), IFN-III, IFN- λ</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c (low), HLA-DR, CD141, CD205, CLEC9A, XCR1, Nec12</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IL-12 (low), IFN-III, IFN-λ</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">cDC2</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, MHC II, CD11b, CD172a (Sirpα), ESAM</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IL-6, TNF</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, HLA-DR, CD1c, CD11b, CD172a (Sirpα), CD1a, CD14, CD5</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IL-12, IL-1β, TNF, IL-6, IL-10, IL-23, IFN-γ</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">pDC</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, MHC II, B220, CD317, SIGLEC-H, CD172a, CD209, CCR2, CCR9, CXCR3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Type I and III IFN</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c (low), HLA-DR (low), CD123, CD303, CD304, CCR2, CXCR3</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Type I and III IFN</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">moDC</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, MHC II, CD11b, CD172, F4/80, Ly6C, CD64 (FcεRI)</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IL-12, IL-23, IL-6, IL-10</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, HLA-DR, CD1c, CD1a, CD11b, CD172a, CD64 (FcεRI), CD14, CD5, CD206</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IL-12, IL-23, IL-6, IL-10</td>
</tr>
<tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">LC</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, CD1d, CD207 (langerin), E-cadherin, MHC II, CD205</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CD11c, CD1a, CD1b, CD1c, CD207 (langerin), E-cadherin, HLA-DR, CD205</td>
<td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>
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