Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities
Identifieur interne : 000A75 ( Pmc/Corpus ); précédent : 000A74; suivant : 000A76Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities
Auteurs : Ahmad Omar Noor ; Diena Mohammedallam Almasri ; Alaa Abdullah Bagalagel ; Hossam Mohamed Abdallah ; Shaimaa Gamal Abdallah Mohamed ; Gamal Abdallah Mohamed ; Sabrin Ragab Mohamed IbrahimSource :
- Molecules [ 1420-3049 ] ; 2020.
Abstract
Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.
Url:
DOI: 10.3390/molecules25020395
PubMed: 31963586
PubMed Central: 7024277
Links to Exploration step
PMC:7024277Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities</title><author><name sortKey="Noor, Ahmad Omar" sort="Noor, Ahmad Omar" uniqKey="Noor A" first="Ahmad Omar" last="Noor">Ahmad Omar Noor</name><affiliation><nlm:aff id="af1-molecules-25-00395">Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</nlm:aff></affiliation></author><author><name sortKey="Almasri, Diena Mohammedallam" sort="Almasri, Diena Mohammedallam" uniqKey="Almasri D" first="Diena Mohammedallam" last="Almasri">Diena Mohammedallam Almasri</name><affiliation><nlm:aff id="af1-molecules-25-00395">Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</nlm:aff></affiliation></author><author><name sortKey="Bagalagel, Alaa Abdullah" sort="Bagalagel, Alaa Abdullah" uniqKey="Bagalagel A" first="Alaa Abdullah" last="Bagalagel">Alaa Abdullah Bagalagel</name><affiliation><nlm:aff id="af1-molecules-25-00395">Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</nlm:aff></affiliation></author><author><name sortKey="Abdallah, Hossam Mohamed" sort="Abdallah, Hossam Mohamed" uniqKey="Abdallah H" first="Hossam Mohamed" last="Abdallah">Hossam Mohamed Abdallah</name><affiliation><nlm:aff id="af2-molecules-25-00395">Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>hmafifi2013@gmail.com</email> (H.M.A.);<email>gamals2001@yahoo.com</email> (G.A.M.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-molecules-25-00395">Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt</nlm:aff></affiliation></author><author><name sortKey="Mohamed, Shaimaa Gamal Abdallah" sort="Mohamed, Shaimaa Gamal Abdallah" uniqKey="Mohamed S" first="Shaimaa Gamal Abdallah" last="Mohamed">Shaimaa Gamal Abdallah Mohamed</name><affiliation><nlm:aff id="af4-molecules-25-00395">Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo 11837, Egypt;<email>shaimaag1973@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Mohamed, Gamal Abdallah" sort="Mohamed, Gamal Abdallah" uniqKey="Mohamed G" first="Gamal Abdallah" last="Mohamed">Gamal Abdallah Mohamed</name><affiliation><nlm:aff id="af2-molecules-25-00395">Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>hmafifi2013@gmail.com</email> (H.M.A.);<email>gamals2001@yahoo.com</email> (G.A.M.)</nlm:aff></affiliation><affiliation><nlm:aff id="af5-molecules-25-00395">Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt</nlm:aff></affiliation></author><author><name sortKey="Ibrahim, Sabrin Ragab Mohamed" sort="Ibrahim, Sabrin Ragab Mohamed" uniqKey="Ibrahim S" first="Sabrin Ragab Mohamed" last="Ibrahim">Sabrin Ragab Mohamed Ibrahim</name><affiliation><nlm:aff id="af6-molecules-25-00395">Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al-Munawwarah 30078, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="af7-molecules-25-00395">Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31963586</idno><idno type="pmc">7024277</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024277</idno><idno type="RBID">PMC:7024277</idno><idno type="doi">10.3390/molecules25020395</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000A75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities</title><author><name sortKey="Noor, Ahmad Omar" sort="Noor, Ahmad Omar" uniqKey="Noor A" first="Ahmad Omar" last="Noor">Ahmad Omar Noor</name><affiliation><nlm:aff id="af1-molecules-25-00395">Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</nlm:aff></affiliation></author><author><name sortKey="Almasri, Diena Mohammedallam" sort="Almasri, Diena Mohammedallam" uniqKey="Almasri D" first="Diena Mohammedallam" last="Almasri">Diena Mohammedallam Almasri</name><affiliation><nlm:aff id="af1-molecules-25-00395">Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</nlm:aff></affiliation></author><author><name sortKey="Bagalagel, Alaa Abdullah" sort="Bagalagel, Alaa Abdullah" uniqKey="Bagalagel A" first="Alaa Abdullah" last="Bagalagel">Alaa Abdullah Bagalagel</name><affiliation><nlm:aff id="af1-molecules-25-00395">Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</nlm:aff></affiliation></author><author><name sortKey="Abdallah, Hossam Mohamed" sort="Abdallah, Hossam Mohamed" uniqKey="Abdallah H" first="Hossam Mohamed" last="Abdallah">Hossam Mohamed Abdallah</name><affiliation><nlm:aff id="af2-molecules-25-00395">Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>hmafifi2013@gmail.com</email> (H.M.A.);<email>gamals2001@yahoo.com</email> (G.A.M.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-molecules-25-00395">Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt</nlm:aff></affiliation></author><author><name sortKey="Mohamed, Shaimaa Gamal Abdallah" sort="Mohamed, Shaimaa Gamal Abdallah" uniqKey="Mohamed S" first="Shaimaa Gamal Abdallah" last="Mohamed">Shaimaa Gamal Abdallah Mohamed</name><affiliation><nlm:aff id="af4-molecules-25-00395">Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo 11837, Egypt;<email>shaimaag1973@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Mohamed, Gamal Abdallah" sort="Mohamed, Gamal Abdallah" uniqKey="Mohamed G" first="Gamal Abdallah" last="Mohamed">Gamal Abdallah Mohamed</name><affiliation><nlm:aff id="af2-molecules-25-00395">Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>hmafifi2013@gmail.com</email> (H.M.A.);<email>gamals2001@yahoo.com</email> (G.A.M.)</nlm:aff></affiliation><affiliation><nlm:aff id="af5-molecules-25-00395">Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt</nlm:aff></affiliation></author><author><name sortKey="Ibrahim, Sabrin Ragab Mohamed" sort="Ibrahim, Sabrin Ragab Mohamed" uniqKey="Ibrahim S" first="Sabrin Ragab Mohamed" last="Ibrahim">Sabrin Ragab Mohamed Ibrahim</name><affiliation><nlm:aff id="af6-molecules-25-00395">Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al-Munawwarah 30078, Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="af7-molecules-25-00395">Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt</nlm:aff></affiliation></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ibrahim, S R" uniqKey="Ibrahim S">S.R. Ibrahim</name></author><author><name sortKey="Abdallah, H M" uniqKey="Abdallah H">H.M. Abdallah</name></author><author><name sortKey="Mohamed, G A" uniqKey="Mohamed G">G.A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Molecules</journal-id><journal-id journal-id-type="iso-abbrev">Molecules</journal-id><journal-id journal-id-type="publisher-id">molecules</journal-id><journal-title-group><journal-title>Molecules</journal-title></journal-title-group><issn pub-type="epub">1420-3049</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31963586</article-id><article-id pub-id-type="pmc">7024277</article-id><article-id pub-id-type="doi">10.3390/molecules25020395</article-id><article-id pub-id-type="publisher-id">molecules-25-00395</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Noor</surname><given-names>Ahmad Omar</given-names></name><xref ref-type="aff" rid="af1-molecules-25-00395">1</xref></contrib><contrib contrib-type="author"><name><surname>Almasri</surname><given-names>Diena Mohammedallam</given-names></name><xref ref-type="aff" rid="af1-molecules-25-00395">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-9909-4881</contrib-id><name><surname>Bagalagel</surname><given-names>Alaa Abdullah</given-names></name><xref ref-type="aff" rid="af1-molecules-25-00395">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-0234-7492</contrib-id><name><surname>Abdallah</surname><given-names>Hossam Mohamed</given-names></name><xref ref-type="aff" rid="af2-molecules-25-00395">2</xref><xref ref-type="aff" rid="af3-molecules-25-00395">3</xref></contrib><contrib contrib-type="author"><name><surname>Mohamed</surname><given-names>Shaimaa Gamal Abdallah</given-names></name><xref ref-type="aff" rid="af4-molecules-25-00395">4</xref></contrib><contrib contrib-type="author"><name><surname>Mohamed</surname><given-names>Gamal Abdallah</given-names></name><xref ref-type="aff" rid="af2-molecules-25-00395">2</xref><xref ref-type="aff" rid="af5-molecules-25-00395">5</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-6858-7560</contrib-id><name><surname>Ibrahim</surname><given-names>Sabrin Ragab Mohamed</given-names></name><xref ref-type="aff" rid="af6-molecules-25-00395">6</xref><xref ref-type="aff" rid="af7-molecules-25-00395">7</xref><xref rid="c1-molecules-25-00395" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-molecules-25-00395"><label>1</label>Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>Aonoor@kau.edu.sa</email> (A.O.N.);<email>dalmasri@kau.edu.sa</email> (D.M.A.);<email>abagalagel@kau.edu.sa</email> (A.A.B.)</aff><aff id="af2-molecules-25-00395"><label>2</label>Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;<email>hmafifi2013@gmail.com</email> (H.M.A.);<email>gamals2001@yahoo.com</email> (G.A.M.)</aff><aff id="af3-molecules-25-00395"><label>3</label>Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt</aff><aff id="af4-molecules-25-00395"><label>4</label>Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo 11837, Egypt;<email>shaimaag1973@gmail.com</email></aff><aff id="af5-molecules-25-00395"><label>5</label>Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt</aff><aff id="af6-molecules-25-00395"><label>6</label>Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al-Munawwarah 30078, Saudi Arabia</aff><aff id="af7-molecules-25-00395"><label>7</label>Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt</aff><author-notes><corresp id="c1-molecules-25-00395"><label>*</label>Correspondence: <email>sribrahim@taibahu.edu.sa</email>; Tel.: +966-581183034</corresp></author-notes><pub-date pub-type="epub"><day>17</day><month>1</month><year>2020</year></pub-date><pub-date pub-type="collection"><month>1</month><year>2020</year></pub-date><volume>25</volume><issue>2</issue><elocation-id>395</elocation-id><history><date date-type="received"><day>09</day><month>12</month><year>2019</year></date><date date-type="accepted"><day>13</day><month>1</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 by the authors.</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.</p></abstract><kwd-group><kwd>endophytes</kwd><kwd>isocoumarins</kwd><kwd>dihydroisocoumarins</kwd><kwd>biosynthesis</kwd><kwd>biological activities</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-molecules-25-00395"><title>1. Introduction</title><p>The search for new metabolites for the agrochemical and pharmaceutical industries is an on-going work that needs continual optimization. Fungi are eukaryotic microorganisms that reside in almost all environmental types in nature where they have key roles in preserving the ecological balance [<xref rid="B1-molecules-25-00395" ref-type="bibr">1</xref>,<xref rid="B2-molecules-25-00395" ref-type="bibr">2</xref>]. Endophytes primarily inhabit their hosts without causing any harm to the hosts [<xref rid="B3-molecules-25-00395" ref-type="bibr">3</xref>,<xref rid="B4-molecules-25-00395" ref-type="bibr">4</xref>,<xref rid="B5-molecules-25-00395" ref-type="bibr">5</xref>,<xref rid="B6-molecules-25-00395" ref-type="bibr">6</xref>]. These endophytic fungi have played pivotal roles in their host’s survival through supplying nutrients and producing plenty of bioactive metabolites to prevent the danger of phytopathogenic bacteria on the host [<xref rid="B7-molecules-25-00395" ref-type="bibr">7</xref>,<xref rid="B8-molecules-25-00395" ref-type="bibr">8</xref>]. Endophytic fungi have gained loads of attention in natural products chemistry field due to their sustainability to biosynthesize structurally diverse and bioactive molecules, some of which are important agrochemicals and pharmaceuticals [<xref rid="B9-molecules-25-00395" ref-type="bibr">9</xref>,<xref rid="B10-molecules-25-00395" ref-type="bibr">10</xref>]. Isocoumarins (1<italic>H</italic>-2-benzopyran-1-ones or isochromene derivatives) are a class of biosynthetically, structurally, and pharmacologically intriguing natural products, which are coumarins isomers with a reversed lactone moiety that could possess 6,8-dioxygenated pattern, 3-(un)substituted phenyl ring or 3-alkyl chain (C<sub>1</sub>-C<sub>17</sub>) [<xref rid="B11-molecules-25-00395" ref-type="bibr">11</xref>,<xref rid="B12-molecules-25-00395" ref-type="bibr">12</xref>]. The oxygenation could exist at one or more of the six free positions of the isocoumarin skeleton. The oxygen atoms may be in the form of ethereal, phenolic, or glycosidic functionalities. Additionally, C-3 substituents are found more commonly on both natural and synthetic isocoumarins derivatives. Substituents that exist on the isocoumarin ring may involve alkyl, halogen, heterocyclic, aryl, or other groups [<xref rid="B13-molecules-25-00395" ref-type="bibr">13</xref>]. Furthermore, the saturation of C-3/C-4 in isocoumarins will give 3,4-dihydroisocoumarins (DHICs) analogs (<xref ref-type="fig" rid="molecules-25-00395-f001">Figure 1</xref>).</p><p>Moreover, isocoumarins and DHICs possess a close relation with isochromans, they are known as isochromen-1-one and isochroman-1-ones, respectively, since the C-1 active methylene in isochromans can be easily oxidized to the related isocoumarins derivatives. Most of the natural isocoumarins and DHICs are given trivial names, which are derived mainly from the name of the species or genus of the host organisms. They have been reported from a broad scope of natural sources, including plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi (e.g., soil, endophytic, and marine fungi) [<xref rid="B14-molecules-25-00395" ref-type="bibr">14</xref>,<xref rid="B15-molecules-25-00395" ref-type="bibr">15</xref>]. Isocoumarins are considered as important intermediates in the synthesis of a wide range of carbo- and heterocyclic compounds such as isoquinolines, isochromenes, and different aromatic compounds [<xref rid="B16-molecules-25-00395" ref-type="bibr">16</xref>]. Thus, isocoumarin framework has been explored in various areas, including drug discovery, pharmaceutical and medicinal chemistry, and organic synthesis [<xref rid="B13-molecules-25-00395" ref-type="bibr">13</xref>]. It has been reported that these metabolites possess various bioactivities: antimicrobial, cytotoxic, algicidal, antiallergic, immunomodulatory, antimalarial, plant growth regulatory, and acetylcholinesterase and protease inhibitors [<xref rid="B11-molecules-25-00395" ref-type="bibr">11</xref>,<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>,<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>,<xref rid="B19-molecules-25-00395" ref-type="bibr">19</xref>,<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>]. This review aims to give a highlight on the naturally occurring isocoumarins derivatives reported from endophytic fungi, focusing on the period from 2000 to July 2019. Herein, 307 naturally occurring isocoumarins derivatives have been listed most of them are reported from <italic>Aspergillus</italic> and <italic>Penicillium</italic> genera (<xref ref-type="fig" rid="molecules-25-00395-f002">Figure 2</xref>). </p><p>The reported fungal isocoumarin derivatives are drawn according to their similarity in the isocoumarin skeleton, as well as nomenclature (<xref ref-type="fig" rid="molecules-25-00395-f003">Figure 3</xref>, <xref ref-type="fig" rid="molecules-25-00395-f004">Figure 4</xref>, <xref ref-type="fig" rid="molecules-25-00395-f005">Figure 5</xref>, <xref ref-type="fig" rid="molecules-25-00395-f006">Figure 6</xref>, <xref ref-type="fig" rid="molecules-25-00395-f007">Figure 7</xref>, <xref ref-type="fig" rid="molecules-25-00395-f008">Figure 8</xref>, <xref ref-type="fig" rid="molecules-25-00395-f009">Figure 9</xref>, <xref ref-type="fig" rid="molecules-25-00395-f010">Figure 10</xref>, <xref ref-type="fig" rid="molecules-25-00395-f011">Figure 11</xref>, <xref ref-type="fig" rid="molecules-25-00395-f012">Figure 12</xref>, <xref ref-type="fig" rid="molecules-25-00395-f013">Figure 13</xref>, <xref ref-type="fig" rid="molecules-25-00395-f014">Figure 14</xref>, <xref ref-type="fig" rid="molecules-25-00395-f015">Figure 15</xref>, <xref ref-type="fig" rid="molecules-25-00395-f016">Figure 16</xref>, <xref ref-type="fig" rid="molecules-25-00395-f017">Figure 17</xref>, <xref ref-type="fig" rid="molecules-25-00395-f018">Figure 18</xref>, <xref ref-type="fig" rid="molecules-25-00395-f019">Figure 19</xref>, <xref ref-type="fig" rid="molecules-25-00395-f020">Figure 20</xref>, <xref ref-type="fig" rid="molecules-25-00395-f021">Figure 21</xref>, <xref ref-type="fig" rid="molecules-25-00395-f022">Figure 22</xref>, <xref ref-type="fig" rid="molecules-25-00395-f023">Figure 23</xref>, <xref ref-type="fig" rid="molecules-25-00395-f024">Figure 24</xref>, <xref ref-type="fig" rid="molecules-25-00395-f025">Figure 25</xref>, <xref ref-type="fig" rid="molecules-25-00395-f026">Figure 26</xref>, <xref ref-type="fig" rid="molecules-25-00395-f027">Figure 27</xref>, <xref ref-type="fig" rid="molecules-25-00395-f028">Figure 28</xref>, <xref ref-type="fig" rid="molecules-25-00395-f029">Figure 29</xref> and <xref ref-type="fig" rid="molecules-25-00395-f030">Figure 30</xref>). </p><p>It is hoped that by using these figures in conjunction with the trivial name, fungal source, host, and place (<xref rid="molecules-25-00395-t001" ref-type="table">Table 1</xref>) the readers will be able to locate key references in the literature and gain much understanding of the fascinating chemistry of these metabolites. Many of these derivatives have substituents at C-3, which could be one carbon or more. The majority of them have an oxygen atom at C-8 and some have the C-6 oxygen. Further alkylation or oxygenation may occur at the remaining positions of the isocoumarin skeleton. Isocoumarins with 3,4-, 4,5-, 5,6-, 6,7-, and 7,8-fused carbocyclic rings are reported. Some of the reported derivatives have chlorine (e.g., <bold>9</bold>, <bold>12</bold>, <bold>22</bold>, and <bold>28</bold>–<bold>31</bold>) or bromine (e.g., <bold>23</bold>, <bold>27</bold>, <bold>32</bold>, and <bold>33</bold>) atom at C-5 and/or C-7. Some show sugar moieties such as glucose (e.g., <bold>15</bold>, <bold>77</bold>–<bold>79</bold>, and <bold>151</bold>) and ribose moiety (e.g., <bold>78</bold> and <bold>79</bold>). In addition, some isocoumarins dimers are reported (e.g., <bold>259</bold>, <bold>260</bold>, and <bold>266</bold>–<bold>268</bold>). Moreover, some linked to other moieties such as anthraquinone and indole diketopiperazine (e.g., <bold>285</bold> and <bold>296</bold>) or contain sulphur (e.g., <bold>278</bold> and <bold>279</bold>) or nitrogen (e.g., <bold>269</bold>–<bold>271</bold>) substituents. This review also mentions briefly their isolation, structural characterization, biosynthesis, and bioactivities (<xref ref-type="fig" rid="molecules-25-00395-f031">Figure 31</xref>, <xref ref-type="fig" rid="molecules-25-00395-f032">Figure 32</xref>, <xref ref-type="fig" rid="molecules-25-00395-f033">Figure 33</xref>, <xref ref-type="fig" rid="molecules-25-00395-f034">Figure 34</xref> and <xref ref-type="fig" rid="molecules-25-00395-f035">Figure 35</xref>, <xref rid="molecules-25-00395-t002" ref-type="table">Table 2</xref> and <xref rid="molecules-25-00395-t003" ref-type="table">Table 3</xref>). Strengthening of their bioactivities may draw the attention of medicinal and synthetic chemists for designing new agents using the known isocoumarins derivatives as raw materials and the discovery of new therapeutic properties not yet attributed to known compounds. The published literature search was conducted over various databases: Web of Science, PubMed, Google Scholar, Scopus, SpringerLink, ACS Publications, Wiley, Taylor and Francis, and Sci-Finder using the keywords (isocoumarin, endophytes, and biological activities). </p></sec><sec id="sec2-molecules-25-00395"><title>2. Biosynthesis</title><p>Isocoumarin was originated of the acetate-malonate or the polyketide synthase (PKS) pathway [<xref rid="B21-molecules-25-00395" ref-type="bibr">21</xref>,<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]. Kurosaki et al. stated that <bold>11</bold> is biosynthesized from malonyl-CoA and acetyl-CoA through a pentaketide [<xref rid="B23-molecules-25-00395" ref-type="bibr">23</xref>]. 3,4-Dihydro-6-hydroxymellein (<bold>III</bold>) is considered as an intermediate which would be transformed to <bold>11</bold> by <italic>O</italic>-methyltransferase which methylates the 6-OH group of the isocoumarin [<xref rid="B23-molecules-25-00395" ref-type="bibr">23</xref>]. The loss of the OH group at C-6 gives rise to mellein [<xref rid="B24-molecules-25-00395" ref-type="bibr">24</xref>]. A heptaketide <bold>II</bold>, a longer polyketone chain is implicated in <bold>165</bold> biosynthesis [<xref rid="B25-molecules-25-00395" ref-type="bibr">25</xref>] (<xref ref-type="fig" rid="molecules-25-00395-f031">Figure 31</xref>). </p><p>Krohn et al. reported that the existence of a biosynthetic relationship between <bold>56</bold> and <bold>125</bold> [<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>]. They assumed that the open-chain precursor <bold>A</bold> can be directly closed to a six-membered lactone (pathway <bold>I</bold>) or cyclized after the side chain rotation through the acetyl enol tautomer to produce <bold>56</bold> (pathway <bold>II</bold>) [<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>] (<xref ref-type="fig" rid="molecules-25-00395-f032">Figure 32</xref>). </p><p>It was postulated that <bold>273</bold> is also derived from the malonate-acetate pathway [<xref rid="B28-molecules-25-00395" ref-type="bibr">28</xref>]. The pentaketide (<bold>I</bold>) cyclization and enolization produce <bold>88</bold>. A Claisen condensation occurs between <bold>88</bold> and tetraketide (<bold>II</bold>) to yield <bold>III</bold>. The side chain enolization, along with the hemiketal formation by the side chain ketone carbonyl and C-6 phenolic OH of the isocoumarin nucleus, forms a hemiketal <bold>IV</bold>. Then, the ketal formation and methylation in the side chain by S-adenosyl methionine (SAM) yield <bold>V</bold> and finally <bold>273</bold> [<xref rid="B28-molecules-25-00395" ref-type="bibr">28</xref>] (<xref ref-type="fig" rid="molecules-25-00395-f033">Figure 33</xref>). </p><p>Moreover, Song et al. reported that an intramolecular cyclization occurs of a polyketide chain (Path A, <xref ref-type="fig" rid="molecules-25-00395-f006">Figure 6</xref>) [<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]. The C-4 substituted derivatives have been resulted from the participation of an additional carbon unit in the cyclization (Path B, <xref ref-type="fig" rid="molecules-25-00395-f034">Figure 34</xref>). </p><p>Therefore, the rare isocoumarin derivatives, <bold>179</bold> and <bold>180</bold> biosynthesis differs from those of <bold>70</bold>, <bold>71</bold>, and <bold>138</bold>, in which a carbon moiety (CH<sub>2</sub>OH) from formate or serine took part in the cyclization. Additionally, the 3-unsubstituted derivatives couldn’t be yielded in the biosynthesis of compounds <bold>138</bold> and <bold>70</bold>; due to the C-11 oxidation is usually taking place after the polyketide chain cyclization [<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]. Chen et al. postulated the biosynthetic origin of <bold>296</bold>, an isocoumarin-indole diketopiperazine alkaloid (<xref ref-type="fig" rid="molecules-25-00395-f035">Figure 35</xref>) [<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]. </p><p>6,8-Dihydroxy-3-(2-oxopropyl)-1H-isochromen-1-one (<bold>I</bold>) was originated from the PKS pathway. It was then chlorinated and <italic>O</italic>-methylated to produce 3-(3-chloro-2-oxopropyl)-6,8-dimethoxy-1H-isochromen-1-one (<bold>II</bold>) by the catalytic effect of a bifunctional hybrid enzyme (BFHEnz). The methyl-carbonyl group of <bold>II</bold> undergoes chlorination and reduction leading to the formation of <bold>235</bold> and <bold>236</bold>, respectively. Then, the hybridization of the diketopiperazine and isocoumarin units by a free radical mechanism, which could be catalyzed by cytochrome P450 giving <bold>296</bold> [<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]. </p></sec><sec id="sec3-molecules-25-00395"><title>3. Structural Characterization of Isocoumarins Derivatives</title><p>Isocoumarins can be characterized by different spectral techniques such as 1D (<sup>1</sup>H, <sup>13</sup>C, and NOE) and 2D NMR techniques (COSY, HSQC, HMBC, ROESY, and NOESY) combined with other usual methods (chemical synthesis, UV, IR, MS, etc.). However, their spectral data cannot be generalized as the data differ to a wide range relying on the type, position, number, and nature of substituents connected to the core skeleton. Furthermore, these data vary basically due to the variation of the core ring. In the compounds having isocoumarins framework, the lactone carbonyl frequency generally appears in the region 1745–1700 cm<sup>−1</sup> in the IR. In <sup>1</sup>H NMR, the C-3 vinylic proton appears at 6.2–7.0 ppm as a singlet or doublet for C<sub>3</sub>-substituted and unsubstituted derivatives, respectively. In <sup>13</sup>C NMR, the lactone C=O appears in the range from 164 ppm to 168 ppm. In the 3-substituted derivatives, C-4 vinylic proton appears at 6.11–6.7 ppm as a singlet. 3,4-Dihydroisocoumarins derivatives have relatively more complicated <sup>1</sup>H NMR spectra than isocoumarins due to C-4 and C-3 vicinal coupling and/or C-4 diastereotopic protons geminal coupling. In both derivatives, the 8-OH group appears at 10.0–12.0 ppm due to the hydrogen bonding to the C-1 carbonyl.</p><p>Mass spectroscopy is a helpful tool for the identification of these metabolites. The existence of sulfur was evident by the intensity of [M + 2]<sup>+</sup> ion peak (∼4.5% of the molecular ion peak) [<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]. Moreover, the chlorine atom in the structure was characterized by two ion peaks [M + H]<sup>+</sup> and [M+2H]<sup>+</sup> in a ratio 3:1 [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>,<xref rid="B32-molecules-25-00395" ref-type="bibr">32</xref>]. The relative configuration was determined by NOE, NOESY, and ROESY. The circular dichroism (CD) is usually utilized to assess the absolute configuration by comparison of the theoretical and experimental CD spectra [<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>,<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>,<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>]. Besides, the total synthesis provides important information and an additional confirmation for characterization of these metabolites structures. Furthermore, it allows the synthesis of analogs with improved biological efficiencies [<xref rid="B11-molecules-25-00395" ref-type="bibr">11</xref>,<xref rid="B34-molecules-25-00395" ref-type="bibr">34</xref>,<xref rid="B35-molecules-25-00395" ref-type="bibr">35</xref>]. The X-ray structure crystallographic analysis of the crystalline derivatives is another tool for the absolute configuration determination. This technique could not be applied in many cases since the crystals with the required qualifications are not available because most of these metabolites do not crystallize conveniently [<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>,<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>,<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]. Finally, the assignment of the absolute configuration could be done using Mosher’s method and the differences in chemical shift between the (<italic>R</italic>)- and (<italic>S</italic>)-MTPA were analyzed [<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>,<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>].</p></sec><sec sec-type="methods" id="sec4-molecules-25-00395"><title>4. Methods of Extraction and Purification of Isocoumarins Derivatives</title><p>For the extraction and isolation of isocoumarins, the fungal material was extracted with CH<sub>2</sub>Cl<sub>2</sub>, acetone or EtOAc. The total extracts were partitioned between n-hexane, CHCl<sub>3</sub>, EtOAc, and MeOH or fractionated on SiO<sub>2</sub> 60 VLC using mixtures of <italic>n</italic>-hexane, EtOAc, and MeOH, or using petroleum ether, CH<sub>2</sub>Cl<sub>2</sub>, and MeOH, respectively [<xref rid="B38-molecules-25-00395" ref-type="bibr">38</xref>,<xref rid="B39-molecules-25-00395" ref-type="bibr">39</xref>,<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]. The fractions were chromatographed over Sephadex LH-20 (CHCl<sub>3</sub>:MeOH 1:1), SiO<sub>2</sub> CC using gradient elution of CH<sub>2</sub>Cl<sub>2</sub>:MeOH; PE:EtOAc; <italic>n</italic>-hexane:EtOAc [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>,<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>,<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>,<xref rid="B41-molecules-25-00395" ref-type="bibr">41</xref>,<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>,<xref rid="B43-molecules-25-00395" ref-type="bibr">43</xref>] or RP-18 CC using MeOH-H<sub>2</sub>O (8:2, <italic>v</italic>/<italic>v</italic>) [<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>]. Purifications of compounds were achieved by preparative HPLC using gradient of MeOH:H<sub>2</sub>O or MeCN:H<sub>2</sub>O [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>,<xref rid="B39-molecules-25-00395" ref-type="bibr">39</xref>,<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]; SiO<sub>2</sub> CC (<italic>n</italic>-hexane:acetone:MeOH, <italic>n</italic>-hexane:acetone gradient or benzene:EtOAc) [<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>,<xref rid="B45-molecules-25-00395" ref-type="bibr">45</xref>,<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]; RP-18 CC (H<sub>2</sub>O:MeOH gradient) [<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]. Preparative TLC could be used for compounds purification using acetone:petroleum ether (3:7) [<xref rid="B41-molecules-25-00395" ref-type="bibr">41</xref>]; CHCl<sub>3</sub>:Me<sub>2</sub>CO:HCO<sub>2</sub>H (97:3:0.01); petrol:CHCl<sub>3</sub> and CHCl<sub>3</sub>:Me<sub>2</sub>CO [<xref rid="B48-molecules-25-00395" ref-type="bibr">48</xref>]; CH<sub>2</sub>Cl<sub>2</sub>:2-propanol (50:1) [<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]; PE:EtOAc (1:1) [<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]. Isocoumarins derivatives can be purified by recrystallization from CH<sub>2</sub>C1<sub>2</sub>:CH<sub>3</sub>OH or PE:EtOAc until they showed constant melting points. These compounds can be detected on TLC by UV light or spraying reagents (vanillin-sulfuric acid or cerium-molybdenum) [<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>].</p></sec><sec id="sec5-molecules-25-00395"><title>5. Biological Activities </title><sec id="sec5dot1-molecules-25-00395"><title>5.1. Antimicrobial Activity</title><p>The isocoumarins <bold>4</bold> and <bold>5</bold> which were produced by an unidentified <italic>Ascomycete</italic>, separated from <italic>Meliotus dentatus</italic> had a potent antibacterial effect towards <italic>B. megaterium</italic> and <italic>E. coli</italic> with equal partial inhibition (PI) 10 and 9 mm, respectively compared to penicillin (PI 18 and 14 mm, respectively) and tetracycline (PI 18 and 18 mm, respectively). Furthermore, <bold>4</bold> and <bold>5</bold> exhibited prominent antifungal activities toward <italic>Botrytis cinerea</italic>, <italic>Microbotryum violaceum</italic>, and <italic>Septoria tritici</italic> and algicidal activities towards <italic>Chlorella fusca</italic> [<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]. Compound <bold>6</bold> was tested against <italic>C. fusca</italic>, <italic>E. coli</italic>, <italic>B. megaterium</italic>, and <italic>M. violaceum</italic> using agar diffusion assay. It showed activity against <italic>C. fusca</italic> (IZD 9 mm), compared to actidione (IZD 35 mm) as well as against <italic>B. megaterium</italic> and <italic>M. violaceum</italic> with IZDs 8 and 6 mm, respectively [<xref rid="B43-molecules-25-00395" ref-type="bibr">43</xref>]. Oliveira et al. indicated that <bold>6</bold> exhibited antifungal potential towards <italic>Cladosporium sphaerospermum</italic> and <italic>C. cladosporioides</italic> with detection limit 10 and 5 μg, respectively, whereas <bold>3</bold> showed moderate activity with detection limit 10 and 25 μg, respectively [<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>]. However, <bold>8</bold> was inactive [<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>]. The new isocoumarins <bold>23</bold>–<bold>29</bold> produced by Lachnum palmae associated with Przewalskia tangutica showed antimicrobial activities against <italic>Penicillium</italic> sp., <italic>C. neoformans</italic>, <italic>C. albicans</italic>, <italic>S. aureus</italic>, and <italic>B. subtilis</italic> (MICs 10–75 µg/mL), compared to kanamycin and amphotericin B using broth microdilution assay. It is noteworthy that <bold>27</bold> had potential antimicrobial potentials towards all the strains tested (MICs 10–55 µg/mL) [<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]. The antifungal effect of <bold>34</bold> separated from <italic>Xylaria</italic> sp. and <bold>36</bold> and <bold>37</bold> separated from <italic>Penicillium</italic> sp. towards <italic>Cladosporium cladosporioides</italic> and <italic>C. sphaerospermum</italic> was assessed using direct bioautography assay [<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]. Compounds <bold>37</bold> and <bold>36</bold> showed a promising effect against <italic>C. sphaerospermum</italic> and <italic>C. cladosporioides</italic> (MICs 10.0 and 5.00 μg, respectively), compared to nystatin (MICs 1.0 and 1.0 μg, respectively), while <bold>34</bold> had moderate effect towards <italic>C. sphaerospermum</italic> and <italic>C. cladosporioides</italic> (MICs 25.0 and 10.0 μg, respectively) [<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]. Furthermore, compound <bold>65</bold> exhibited moderate effect towards <italic>Vibrio parahemolyticus</italic> and <italic>B. cereus</italic> with MICs 6.25 μM [<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]. Furthermore, <bold>35</bold> exhibited only weak potential towards <italic>Botrytis cinerea</italic> (EC<sub>50</sub> 49.2 μg/mL) [<xref rid="B53-molecules-25-00395" ref-type="bibr">53</xref>]. However, <bold>78</bold> and <bold>79</bold> showed no antifungal activity (Conc. 128 μg/mL) toward <italic>C. albicans</italic> (ATCC10231 and ATCC32354) [<xref rid="B54-molecules-25-00395" ref-type="bibr">54</xref>]. Compounds <bold>59</bold>, <bold>116</bold>, <bold>124</bold>, and <bold>125</bold> were tested against three fungal organisms: <italic>Eurotium repens</italic>, <italic>Mycotypha rnicrospora</italic>, and <italic>Ustilago violacae</italic>. Only <bold>59</bold> had a moderate potential towards all tested fungi [<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>]. Compound <bold>132</bold> was evaluated for the antimicrobial effect towards <italic>Cladosporium herbarum</italic>, <italic>Aspergillus niger</italic>, <italic>B. subtilis</italic>, and <italic>Pseudomonas syringae</italic>. The results revealed that <bold>132</bold> exhibited only mild activity towards <italic>B. subtilis</italic> with MIC 25 μg/mL, compared to chloramphenicol (MIC 3.13 μg/mL) [<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]. The dihydroisocoumarins <bold>154</bold> and <bold>155</bold> showed selective antibacterial potential against the five pathogenic bacteria <italic>S. epidermidis</italic>, <italic>B. cereus</italic>, <italic>S. aureus</italic>, <italic>Vibrio alginolyticus</italic>, and <italic>E. coli</italic> (MICs 20, 20, 20, 20, and 20 µM, respectively for <bold>154</bold> and 10, 20, 20, 20, and 20 µM, respectively for <bold>155</bold>), compared to ciprofloxacin (MICs 0.30, 0.30, 1.20, 0.60, and 1.25 µM, respectively) [<xref rid="B56-molecules-25-00395" ref-type="bibr">56</xref>]. The antibacterial activities of <bold>188</bold>, <bold>189</bold>, and <bold>193</bold> were tested against <italic>B. megaterium</italic>, <italic>B. subtilis</italic>, <italic>E. coli</italic>, <italic>Micrococcus tetragenus</italic>, <italic>Clostridium perfringens</italic>, and MRSA <italic>S. aureus</italic>. Compound <bold>189</bold> had a stronger antibacterial potential (MIC 12.5 μg/mL) against <italic>B. megaterium</italic> than ampicillin (MIC 50 μg/mL). However, the other compounds did not exhibit any activity [<xref rid="B57-molecules-25-00395" ref-type="bibr">57</xref>]. Compounds <bold>70</bold>, <bold>71</bold>, <bold>138</bold>, <bold>179</bold>, and <bold>180</bold> which were isolated from <italic>Pestalotiopsis</italic> sp. associated with <italic>Photinia frasery</italic> were evaluated for their antimicrobial activities towards <italic>P. aeruginosa</italic> (ATCC 9027), <italic>S. aureus</italic> (ATCC 25923), <italic>E. coli</italic> (ATCC 25922), <italic>B. subtilis</italic> (ATCC 6633)<italic>,</italic> and <italic>C. glabrata</italic> (ATCC 90030). It is noteworthy that only <bold>138</bold> had a promising antifungal capacity against <italic>C. glabrata</italic> (MIC<sub>50</sub> 3.49 μg/mL) in comparison to amphotericin B (MIC<sub>50</sub> 0.25 μg/mL). Whilst, the other metabolites had no activity (Conc. 50 μg/mL) [<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]. The antimicrobial activity of <bold>157</bold>–<bold>159</bold> towards different aquatic and human pathogenic bacteria (<italic>E. coli</italic>, <italic>Aeromonas hydrophilia</italic>, <italic>P. aeruginosa</italic>, <italic>Micrococcus luteus</italic>, <italic>Vibrio alginolyticus</italic>, <italic>V. parahaemolyticus</italic>, and <italic>V. harveyi</italic>) and plant pathogenic fungi (<italic>Colletotrichum gloeosprioides</italic> and <italic>Phytophthora parasitica var. nicotianae</italic>) was evaluated. They had broad-spectrum antifungal and antibacterial capacities with MICs ranging from 4 to >64 µg/mL. Compound <bold>157</bold> possessed the highest activities against <italic>P. aeruginosa, E. coli</italic>, <italic>V. harveyi</italic>, <italic>C. gloeosprioides</italic> and <italic>V. parahaemolyticus</italic> (MICs 4 µg/mL), whereas <bold>158</bold> and <bold>159</bold> displayed moderate activities against these microorganisms [<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]. Compound <bold>165</bold> (Conc. 500–7.8 μg/mL) which was biosynthesized by <italic>Exserohilum rostratum</italic> isolated from <italic>Bauhinia guianensis</italic> possessed a good activity towards <italic>B. subtilis</italic> (MBC 62.5 μg/mL and MIC 15.62 μg/mL), <italic>E. coli</italic> (MBC 250 μg/mL and MIC 15.62 μg/mL), <italic>P. aeruginosa</italic> (MIC 15.62 μg/mL), <italic>S. Typhimurium</italic> (MIC 31.25 μg/mL), and <italic>S. aureus</italic> (MIC 62.5 μg/mL) [<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]. <italic>Microdochium bolleyi</italic> metabolites: <bold>165</bold>, <bold>167</bold>, <bold>169</bold>, and <bold>240</bold> were estimated for their antibacterial, antifungal, and algicidal effects toward <italic>E. coli</italic>, <italic>B. megaterium</italic>, <italic>M. Violaceum</italic>, and <italic>C. fusca</italic> using agar diffusion assay. Compounds <bold>165</bold>, <bold>169</bold>, and <bold>240</bold> inhibited the four tested organisms. It is noteworthy that <bold>167</bold> showed an algicidal potential towards <italic>C. fusca</italic> (IZD 6 mm, actidione IZD 50 mm and nystatin IZD 20 mm) and an antifungal effect against <italic>M. violaceum</italic> (IZD 7 mm, tetracycline IZD 10 mm and actidione IZD 35 mm), but did not have an antibacterial effect [<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]. Hussain et al. stated that <bold>197</bold> showed potential antifungal and antibacterial activities against <italic>M. violaceum</italic> (IZD 10 mm) and <italic>B. megaterium</italic> (IZD 5 mm), respectively [<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]. Compounds <bold>165</bold>, <bold>167</bold>–<bold>171</bold>, <bold>175</bold>–<bold>177</bold>, and <bold>201</bold> were tested for their antimicrobial potential towards <italic>S. aureus</italic> (CGMCC 1.2465), <italic>B. subtilis</italic> (ATCC 6633), <italic>S</italic>. <italic>pneumoniae</italic> (CGMCC 1.1692), <italic>F. oxysporum</italic> (CGMCC 3.2830), and <italic>E. coli</italic> (CGMCC 1.2340) [<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]. Compounds <bold>167</bold> and <bold>177</bold> displayed antifungal potential towards <italic>F. oxysporum</italic> with MICs 20 μg/mL, compared to amphotericin B (MIC 0.63 μg/mL). Furthermore, <bold>201</bold> exhibited significant antibacterial effects against <italic>B. subtilis</italic>, <italic>S. pneumonia</italic>, and <italic>S. aureus</italic> with MICs 20, 10, and 5 μg/mL, respectively in comparison to ampicillin (MICs 1.25, 10, and 0.16 μg/mL, respectively). Furthermore, it had a promising effect towards <italic>E. coli</italic> (MIC 20 μg/mL), compared to gentamicin (MIC 2.5 μg/mL) [<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]. Arunpanichlert et al. reported that <bold>213</bold> had a mild antifungal effect against <italic>Cryptococcus neoformans</italic> and <italic>C. albicans</italic> with equal MICs of 200 μg/mL, while <bold>212</bold> was inactive (Conc. 200 mg/mL) [<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]. Furthermore, <bold>212</bold> and <bold>213</bold> had a weak antibacterial effect against <italic>B. subtilis</italic> and <italic>S. aureus</italic> (Conc. 50 µg/mL) [<xref rid="B61-molecules-25-00395" ref-type="bibr">61</xref>]. Chen et al. reported that the isocoumarins metabolites <bold>54</bold>, <bold>64</bold>–<bold>66</bold>, <bold>84</bold>, <bold>92</bold>–<bold>95</bold>, <bold>150</bold>, <bold>158</bold>, <bold>159</bold>, <bold>212</bold>, <bold>213</bold>, <bold>216</bold>, and <bold>217</bold> which were separated from <italic>Talaromyces amestolkiae</italic>, did not exhibit any antibacterial activity against <italic>Staphylococcus epidermidis, S. aureus, Klebsiella pneumoniae, E. coli,</italic> and <italic>B. subtilis</italic> [<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]. Compounds <bold>98</bold>, <bold>99</bold>, <bold>276</bold>–<bold>285</bold>, and <bold>294</bold> which were biosynthesized by <italic>Aspergillus banksianus</italic>, were tested for in vitro antimicrobial activities against <italic>E. coli</italic> (ATCC 25922), <italic>B. subtilis</italic> (ATCC 6633), <italic>Saccharomyces cerevisiae</italic> (ATCC 9763), and <italic>C. albicans</italic> (ATCC 10231). Compounds <bold>283</bold>–<bold>285</bold> displayed weak to moderate activities, whereas the other metabolites had no activity towards any of the tested strains [<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]. Compound <bold>232</bold> showed a weak activity towards <italic>B. subtilis</italic> ATCC 6633 and <italic>Trichophyton rubrum</italic> ATCC 28,189 with MIC<sub>80</sub> 19.7 and 32.0 μg/mL, respectively, compared to penicillin (MIC<sub>80</sub> 0.9 μg/mL) and fluconazole (MIC<sub>80</sub> 1.0 μg/mL) [<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]. Moreover, compounds <bold>172</bold>, <bold>173</bold>, and <bold>178</bold> isolated from <italic>Setosphaeria</italic> sp. possessed no activity towards <italic>S. aureus, Colletotrichum asianum, C. gloeosporioides, C. acutatum, Pyricularia oryza</italic>, and <italic>F. oxysporum</italic> using broth microdilution technique [<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]. Compounds <bold>72</bold>, <bold>188</bold>, <bold>189</bold>, <bold>202</bold>–<bold>205</bold>, <bold>207</bold>–<bold>211</bold>, <bold>231</bold>, <bold>233</bold>, <bold>234</bold>, <bold>286</bold>, and <bold>287</bold> were evaluated against <italic>Agrobacterium tumefaciens</italic>, <italic>E. coli</italic>, <italic>Ralstonia solanacearum, S. aureus</italic>, <italic>Bacillus thuringensis</italic>, <italic>Xanthomonas vesicatoria</italic>, and <italic>Pseudomonas lachrymans</italic>. The metabolite <bold>188</bold> showed moderate inhibitory effect towards <italic>A</italic>. <italic>tumefaciens, R</italic>. <italic>solanacearum,</italic> and <italic>S</italic>. <italic>aureus</italic> with MICs 16 μM, while <bold>189</bold> and <bold>234</bold> had weak inhibition (MICs 32 μM) against <italic>A. tumefaciens</italic> and <italic>R. solanacearum</italic>, respectively [<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]. The isocoumarins <bold>88</bold>–<bold>90</bold> and <bold>272</bold> exhibited no activities (MIC > 256 μg/mL) towards <italic>P. aeruginosa, B. subtilis, S. aureus, E. coli,</italic> and <italic>C. albicans</italic> [<xref rid="B48-molecules-25-00395" ref-type="bibr">48</xref>]. The antifungal activity of <bold>220</bold> and <bold>290</bold> was assessed using the broth dilution method. Compound <bold>290</bold> showed significant antifungal capacity towards <italic>Rhizoctonia solani</italic> (MIC 6.25 μg/mL), compared to carbendazim (MIC 6.25 μg/mL) and moderate effect against <italic>Colletotrichum musae</italic> (MIC 25 μg/mL), whereas <bold>220</bold> exhibited weak activities toward these two fungi (MICs 150 μg/mL). However, none of these metabolites was active towards <italic>Fusarium graminearum</italic> and <italic>Penicillium italicum</italic> (MICs > 200 μg/mL) [<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]. Compounds <bold>188</bold>, <bold>193</bold>–<bold>196</bold>, <bold>232</bold>, and <bold>299</bold> biosynthesized by <italic>Alternaria alternata</italic> were tested against <italic>B. subtilis</italic> ATCC 6633, <italic>S. aureus</italic> ATCC 25923, <italic>T. rubrum</italic> ATCC 28189, and <italic>C. albicans</italic> ATCC 24433. Compound <bold>194</bold> ([(−)- and (+)] displayed moderate effects against <italic>S. aureus</italic> (MICs 15.4 and 17.1 μg/mL, respectively), compared to penicillin MIC 1.2 μg/mL) whereas <bold>193</bold>, <bold>195</bold> ([(−)- and (+)], and <bold>196</bold> had no prominent effect. These results demonstrated that the 2-OH acetylation could enhance the activity towards <italic>S. aureus</italic>, however, the enantiomeric difference may have a negligible influence. Furthermore, (+)-<bold>194</bold> and (+)-<bold>195</bold> showed promising potential towards <italic>C. albicans</italic>, while (−)-<bold>194</bold> and (−)-<bold>195</bold> had less activities, suggesting the difference in the antifungal potentials among the different enantiomers. Moreover, <bold>188</bold> possessed the highest activity towards <italic>B. subtilis</italic> (MIC 8.6 μg/mL). Whilst <bold>232</bold> had no activity. [<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>] Bai et al. stated that compounds <bold>186</bold>, <bold>187</bold>, <bold>244</bold>, <bold>245</bold>, and <bold>248</bold> had no antibacterial potential towards <italic>E. coli</italic>, MRSA <italic>S. aureus</italic>, <italic>S. aureus</italic>, <italic>B. cereus</italic>, <italic>Vibrio alginolyticus</italic>, and <italic>V. parahaemolyticus</italic> using microplate assay [<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]. Chen et al. reported that <bold>296</bold> had mild activity against <italic>C</italic>. <italic>albicans</italic> (MIC 32.0 μg/mL), compared to caspofungin (MIC 0.03 μg/mL) [<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]. Compounds <bold>1</bold>, <bold>2</bold>, and <bold>16</bold> demonstrated a significant potential against <italic>Trichophyton longifusus</italic> and <italic>Microsporum canis</italic> (% inhibition 45, 70, and 55, respectively and 50, and 50, and 70, respectively), compared to miconazole, (% inhibition 70 and 98.4, respectively), whereas they were inactive towards <italic>C. albicans</italic>, <italic>Fusarium solani</italic>, <italic>C. glabrata</italic>, and <italic>Aspergillus flavus</italic> using agar tube dilution technique [<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]. The antimicrobial potential of <bold>237</bold> and <bold>238</bold> separated <italic>Trichoderma harzianum</italic> was investigated towards <italic>B. subtilis</italic>, <italic>E. coil</italic>, <italic>C. albicans</italic>, <italic>S. aureus</italic>, and <italic>P. aeruginosa</italic> using well diffusion technique. They had a weak inhibitory effect against <italic>E. coli</italic> (MICs 32 μg/mL), compared to chloramphenicol (MIC 4 μg/mL), whereas they were inactive towards the other tested microorganisms [<xref rid="B69-molecules-25-00395" ref-type="bibr">69</xref>]. Compounds <bold>46</bold> and <bold>73</bold> new isocoumarins reported from <italic>Aspergillus</italic> sp. SCSIO 41,501 derived from marine gorgonian <italic>Melitodes squamata</italic> were inactive against <italic>E. coli</italic> and <italic>B. subtilis</italic> using disc diffusion technique [<xref rid="B70-molecules-25-00395" ref-type="bibr">70</xref>]. The new isocoumarins metabolites, <bold>13</bold>, <bold>106</bold>, and <bold>107</bold> isolated <italic>Botryosphaeria ramosa</italic> were assessed for their antifungal potential towards <italic>F. oxysporum</italic>, <italic>P. italicum</italic>, and <italic>F. graminearum</italic>. Compounds <bold>13</bold> and <bold>107</bold> demonstrated a high inhibitory potential against <italic>F. graminearum</italic> and <italic>F. oxysporum</italic> (MICs 223 and 223 μM and 211.7 and 105.8 μM and respectively) in comparison to triadimefon (MICs 510.7 and 340.4 μM, respectively), whereas <bold>106</bold> had a significant activity against <italic>F. oxysporum</italic> (MIC 112.6 μM) and a weak effect towards <italic>F. graminearum</italic> (MIC 900 μM) [<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]. Xu et al. reported that <bold>145</bold> displayed moderate activities against <italic>P. aeruginosa</italic> (MIC 50 μg/mL) and <italic>E. coli</italic> (MIC 12.5 μg/mL), compared to ciprofloxacin (0.078 and 0.625 μg/mL, respectively) [<xref rid="B72-molecules-25-00395" ref-type="bibr">72</xref>]. The anti-bacterial activity of <bold>100</bold>, <bold>220</bold>, <bold>239</bold>, <bold>274</bold>, and <bold>275</bold> towards <italic>K. pneumonia</italic>, <italic>S. epidermidis</italic>, <italic>E. coli</italic>, <italic>S. aureus</italic>, and <italic>B. subtilis</italic> was assessed. Only <bold>220</bold> had activities against <italic>B. subtilis</italic> and <italic>S. aureus</italic> (MICs 25 μg/mL). While <bold>100</bold>, <bold>239</bold>, <bold>274</bold>, and <bold>275</bold> (Conc. 25 μg/mL) did not exhibit any activity against the tested strains [<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]. Compounds <bold>162</bold>–<bold>164</bold>, novel dihydroisocoumarins isolated <italic>Geotrichum</italic> sp., associated with <italic>Crassocephalum crepidioides</italic> had been tested for the antifungal activity towards <italic>C. albicans</italic> using colorimetric technique [<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]. Compounds <bold>162</bold> and <bold>164</bold> had a weak antifungal potential towards <italic>C. albicans</italic> (IC<sub>50</sub>s 13 and 33 μg/mL, respectively), compared to amphotericin B (IC<sub>50</sub> 0.01 μg/mL). Whilst <bold>163</bold> had no activity [<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]. Compounds <bold>51</bold>, <bold>146</bold>, and <bold>147</bold> possessed antibacterial potential towards <italic>B. subtilis</italic> (MICs 100, 50, and 25 μg/mL, respectively) and <italic>S</italic>. <italic>aureus</italic> (MICs 100, 25, and 25 μg/mL, respectively), compared to ciprofloxacin (MICs 0.25 and 0.13 μg/mL, respectively). However, they were inactive against <italic>E. coli</italic>, <italic>C. albicans</italic>, <italic>C. parapsilosis</italic>, and <italic>Cryptococcus neoformans</italic> [<xref rid="B75-molecules-25-00395" ref-type="bibr">75</xref>]. The new isocoumarins <bold>261</bold>–<bold>266</bold> which were produced by <italic>Aspergillus</italic> sp. 085,242 separated from <italic>Acanthus ilicifolius</italic> roots exhibited no antibacterial capacity towards <italic>Staphylococcus epidermidis</italic>, <italic>S. aureus</italic>, <italic>E. coli</italic>, <italic>B. subtilis</italic>, and <italic>Klebsiella pneumoniae</italic> [<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]. Compound <bold>297</bold> had a moderate antifungal capacity towards <italic>Botrytis cinerea</italic>, <italic>S. sclerotiorum</italic>, <italic>Phytophthora capsici</italic>, <italic>Fusarium graminearum</italic>, <italic>and F. moniliforme</italic> (inhibition rates 18.8, 39.0, 13.7, 24.0, and 31.6%, respectively) [<xref rid="B77-molecules-25-00395" ref-type="bibr">77</xref>]. The isocoumarins <bold>151–153</bold>, <bold>214</bold>, <bold>215</bold>, and <bold>295</bold> had no activity against <italic>B. cereus</italic>, <italic>E. coli</italic>, <italic>S. albus</italic>, <italic>S. aureus</italic>, <italic>B. subtilis</italic>, <italic>Kocuria rhizophila</italic>, <italic>Micrococcus tetragenus</italic>, <italic>Vibrio anguillarum</italic>, and <italic>V. parahemolyticus</italic>, whereas <bold>153</bold> possessed weak activity (MIC 12.5 μM) against <italic>S. aureus</italic> compared to ciprofloxacin (MIC 0.160 μM) [<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]. Compounds <bold>42</bold>, <bold>304</bold>, and <bold>306</bold> reported from <italic>Seltsamia galinsogisoli</italic> were assessed for the antimicrobial effect towards <italic>S. aureus</italic>, <italic>P. aeruginosa</italic>, <italic>B. subtilis</italic>, <italic>B. cereus</italic>, and <italic>K. pneumonia</italic> [<xref rid="B78-molecules-25-00395" ref-type="bibr">78</xref>]. Compound <bold>306</bold> had selective activity against <italic>S. aureus</italic> (MIC 32 μg/mL), whereas <bold>42</bold> and <bold>304</bold> exhibited weak effects [<xref rid="B78-molecules-25-00395" ref-type="bibr">78</xref>].</p></sec><sec id="sec5dot2-molecules-25-00395"><title>5.2. Cytotoxic Activity</title><p>The cytotoxic activities of isocoumarins have been assessed towards various cancer cell lines using various assays and the most active compounds have been listed in <xref rid="molecules-25-00395-t003" ref-type="table">Table 3</xref>.</p><p>The cytotoxicity of <bold>203</bold>, <bold>219</bold>, and <bold>221</bold> reported from <italic>Ampelomyces</italic> sp. associated with <italic>Urospermum picroides</italic> was assessed against L5178Y (mouse lymphoma) cells using MTT assay. Interestingly, <bold>203</bold> had a strong cytotoxic activity with EC<sub>50</sub> 7.3 μg/mL [<xref rid="B39-molecules-25-00395" ref-type="bibr">39</xref>]. Compound <bold>289</bold> isolated from <italic>Trichoderma</italic> sp. was moderately active against HepG2 and MCF-7 cell lines (IC<sub>50</sub>s 39.6 and 17.8 μg/mL, respectively) by MTT assay compared with epirubicin (IC<sub>50</sub>s 5.3 and 5.2 μg/mL, respectively) [<xref rid="B79-molecules-25-00395" ref-type="bibr">79</xref>]. The cytotoxicity of <bold>165</bold> and <bold>168</bold> towards CHAGO, BT474, HepG2, SW-620, and KATO-3 carcinomas was estimated using MTT colorimetric assay [<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]. None of these metabolites was cytotoxic (Conc. 20 μg/mL) [<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]. Compounds <bold>160</bold>, <bold>161</bold>, <bold>165</bold>, and <bold>166</bold> were evaluated for the cytotoxic activity towards HuCCA-1, HepG2, MOLT-3, and A549 [<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]. They were weakly cytotoxic (IC<sub>50</sub> 115.3–153.0 μM). Interestingly, <bold>166</bold> possessed selective cytotoxic activity (IC<sub>50</sub> 23.7 μM) toward HepG2 cell line, compared to etoposide (IC<sub>50</sub> 15.8 μM) [<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]. Arunpanichlert et al. stated that <bold>61</bold>, <bold>212</bold>, and <bold>213</bold> which were separated from <italic>Pestalotiopsis</italic> sp., had no activity towards MCF-7, noncancerous Vero cell, and human oral cavity cancer [<xref rid="B41-molecules-25-00395" ref-type="bibr">41</xref>]. Furthermore, the isocoumarin metabolites, <bold>3</bold>, <bold>88</bold>, <bold>131</bold>, <bold>165</bold>, and <bold>293</bold> biosynthesized by <italic>Botryosphaeria</italic> sp. KcF6 did not have cytotoxic capacity towards MCF-7, K562, U937, A549, HeLa, HL-60, DU145, MOLT-4, and BGC823 cancer cell lines [<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]. Compounds <bold>204</bold>, <bold>222</bold>–<bold>230</bold>, <bold>258</bold>, <bold>267</bold>, and <bold>268</bold> did not exhibit cytotoxic potential towards MCF-7, HepG2, A549, HEK293T, and HeLa cell lines [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]. Ebada et al. reported that <bold>259</bold> and <bold>260</bold> (Conc. 10 μg/mL) had cytotoxic potential against L5178Y cell line with % growth inhibition 33 and 13, respectively using MTT assay [<xref rid="B81-molecules-25-00395" ref-type="bibr">81</xref>]. The isocoumarins <bold>98</bold>, <bold>99</bold>, <bold>276</bold>–<bold>285</bold>, and <bold>294</bold> biosynthesized by <italic>Aspergillus banksianus</italic> were tested for in vitro activity against NS-1 cells. Compounds <bold>283</bold>–<bold>285</bold> displayed weak to moderate activity, whereas the other metabolites had no activity [<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]. Compound <bold>100</bold> possessed no cytotoxicity against A2780 cell line [<xref rid="B82-molecules-25-00395" ref-type="bibr">82</xref>]. Compounds <bold>78</bold> and <bold>79</bold>, isocoumarin ribonic glycosides biosynthesized by <italic>Daldinia eschscholzii</italic>, had no obvious activity (IC<sub>50</sub> > 40 μg/mL) towards SMMC-7721, HL-60, A-549, SW-480, and MCF-7 using the MTT assay [<xref rid="B54-molecules-25-00395" ref-type="bibr">54</xref>]. Compounds <bold>183</bold> and <bold>184</bold> were obtained from <italic>Talaromyces</italic> sp. that inhabited <italic>Cedrus deodara</italic>, showed cytotoxic potential towards HEP-1, A-549, THP-1, HCT, and PC-3 cell lines (% inhibition 23, 15, 54, 44, and 23%, respectively for <bold>183</bold> and 3, 35, 40, 35, and 34%, respectively for <bold>184</bold>) [<xref rid="B83-molecules-25-00395" ref-type="bibr">83</xref>]. Phomasatin (<bold>141</bold>) showed no cytotoxicity (IC<sub>50</sub> > 50 µM) against Molm 1, HL-60, and PC-3 cell lines using MTT assay [<xref rid="B84-molecules-25-00395" ref-type="bibr">84</xref>]. Compounds <bold>154</bold> and <bold>155</bold> had no cytotoxic potential against HeLa, MCF-7, and A549 cells (IC<sub>50</sub> > 50 µM) [<xref rid="B56-molecules-25-00395" ref-type="bibr">56</xref>]. Compounds <bold>157</bold>–<bold>159</bold>, dihydroisocoumarin derivatives reported from <italic>Penicillium simplicissimum</italic> were examined against <italic>Artemia salina</italic> (brine shrimp lethality). They showed brine shrimp lethality with LD<sub>50</sub> 7.7, 36.4, and 18.6 µg/mL, respectively compared to colchicine (LD<sub>50</sub> 16.5 µg/mL) [<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]. Alternariol (<bold>188</bold>) was reported to prevent cell proliferation by intervention with the cell cycle. The MTT assay results of the related derivatives from <italic>Alternaria</italic> sp. indicated that all alternariol derivatives demonstrated activity toward the L5178Y, except for <bold>190</bold> and <bold>192</bold>. Compound <bold>188</bold> was the highly active metabolite (EC<sub>50</sub> 1.7 μg/mL), whereas <bold>189</bold> and <bold>191</bold> had activity with EC<sub>50</sub>s 7.8 and 4.5 μg/mL, respectively. However, <bold>193</bold> was inactive [<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]. Compounds <bold>269</bold>–<bold>271</bold> obtained from <italic>Alternaria tenuis</italic> were tested for their in vitro cytotoxicity against A375-S2 and HeLa cells using MTT assay. Compounds <bold>269</bold> and <bold>271</bold> had a potent effect with IC<sub>50</sub>s 0.1 and 0.02 mM and 0.3 and 0.05 mM, respectively. However, <bold>270</bold> displayed only weak activity (IC<sub>50</sub> 0.4 mM) to HeLa cells [<xref rid="B85-molecules-25-00395" ref-type="bibr">85</xref>]. Fusariumin (<bold>298</bold>) a new isocoumarin derivative (Conc. 10 µg/mL) which was isolated from <italic>Fusarium</italic> sp. displayed a significant growth inhibitory potential against <italic>A. salina</italic> with mortality rate 78.2% [<xref rid="B86-molecules-25-00395" ref-type="bibr">86</xref>]. Wang et al. reported that <bold>188</bold>, <bold>193</bold>–<bold>196</bold>, <bold>232</bold>, and <bold>299</bold> were inactive (Conc. 50.0 μM) towards U2OS and HepG2 using the MTT method [<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]. Furthermore, compounds <bold>186</bold>, <bold>187</bold>, <bold>244</bold>, <bold>245</bold>, and <bold>248</bold> had no activity towards HeLa, HepG2, and A549 cell lines [<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]. Furthermore, <bold>46</bold> and <bold>73</bold> possessed no cytotoxicity towards MCF-7, HepG2, and HL60 cell lines using MTT assay [<xref rid="B70-molecules-25-00395" ref-type="bibr">70</xref>]. Compound <bold>296</bold> possessed significant cytotoxicity towards AsPC-1 and MIA-PaCa-2 cell lines with IC<sub>50</sub>s 5.53 and 1.63 μM, respectively, in comparison to gemcitabine (IC<sub>50</sub>s 20.10 and 1.02 μM, respectively) [<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]. Compounds <bold>100</bold>, <bold>220</bold>, <bold>239</bold>, <bold>274</bold>, and <bold>275</bold> were assessed for their cytotoxic effects towards HepG2, MDA-MB-435, HCT116, MCF10A, and H460 cell lines [<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]. It is noteworthy that <bold>274</bold> had a selective cytotoxic potential towards HepG2, MDA-MB-435, MCF10A, and H460 (IC<sub>50</sub>s 43.70, 5.08, 11.34, and 21.53 μM, respectively) comparable to epirubicin (IC<sub>50</sub>s 0.32, 0.26, 0.13, 0.12 μM, respectively), whereas <bold>275</bold> showed a selective effect against MCF10A and MDA-MB-435 (IC<sub>50</sub>s 21.40 and 4.98 μM, respectively). However, other metabolites (Conc. 50 μM) did not affect all tested cell lines [<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]. The new isocoumarin metabolite, <bold>20</bold> isolated from <italic>Bruguiera sexangula</italic> root-associated fungus <italic>Penicillium sp</italic>. 091,402 exhibited moderate cytotoxicity potential towards K562 (IC<sub>50</sub>18.9 μg/mL) [<xref rid="B87-molecules-25-00395" ref-type="bibr">87</xref>]. Huang et al. reported that <bold>142</bold> prohibited HepG2 and Hep-2 cells growth (IC<sub>50</sub>s 55 and 52 μg/mL, respectively) using MTT method [<xref rid="B88-molecules-25-00395" ref-type="bibr">88</xref>]. The cytotoxic potential of <bold>252</bold> isolated <italic>Aspergillus versicolor</italic> was estimated towards A549, NB4, PC3, SHSY5Y, and MCF7. Interestingly, it had a higher activity towards MCF7 and A549 with IC<sub>50</sub>s 8.0 and 5.8 μM, respectively [<xref rid="B89-molecules-25-00395" ref-type="bibr">89</xref>]. The new isocoumarin, <bold>108</bold> isolated from <italic>Arthrinium sacchari</italic> displayed a weak cytotoxic effect towards HUVECs and HUAECs (IC<sub>50</sub> 70.8 and 277.1 μM, respectively), compared to Ki8751 (IC<sub>50</sub>s 1.0–2.0 μM) using MTT assay [<xref rid="B90-molecules-25-00395" ref-type="bibr">90</xref>]. Compound <bold>35</bold> did not have a cytotoxic effect against MRC-5 and AGS cell lines [<xref rid="B91-molecules-25-00395" ref-type="bibr">91</xref>]. Moreover, <bold>6</bold> possessed no cytotoxic capacity against NCIH460, MCF-7, and A375-C5 cell lines using the protein binding dye SRB method [<xref rid="B92-molecules-25-00395" ref-type="bibr">92</xref>]. The cytotoxic abilities against A549, NB4, MCF7, SHSY5Y, and PC3 tumor cell lines of <bold>38</bold>, <bold>52, 53</bold>, <bold>127</bold>, <bold>137</bold>, <bold>251</bold>, and <bold>301</bold> were tested [<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]. Compound <bold>251</bold> exhibited a high cytotoxic effect towards MCF7 and A549 cells (IC<sub>50</sub> 3.8 and 4.0 μM, respectively), in comparison to taxol (IC<sub>50</sub> 0.1 and 0.02 μM, respectively), while the other compounds had moderate cytotoxic capacities towards some of the tested cell lines with IC<sub>50</sub>s less than 10 [<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]. Compounds <bold>23</bold>–<bold>29</bold> were assessed for their cytotoxic capacities towards HepG2, HL-60, and SGC-7901 using MTT method. Only <bold>27</bold> had weak cytotoxicity towards HepG2 (IC<sub>50</sub> 42.8 µM) [<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]. The cytotoxic effect of <bold>111</bold> and <bold>112</bold> towards NB4, SHSY5Y, A549, MCF7, and PC3 using MTT assay was evaluated [<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]. They had moderate to weak inhibitory capacities against some tested human tumor cell lines (IC<sub>50</sub>s 2.8–8.8 µM) [<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]. Penicimarins <bold>151</bold>–<bold>153</bold>, <bold>214</bold>, <bold>215</bold>, and <bold>259</bold> had no cytotoxic activity towards HL-60, HeLa cell, A-549, and K562 cell lines [<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]. </p></sec><sec id="sec5dot3-molecules-25-00395"><title>5.3. Antioxidant Activity </title><p>Choudhary et al. reported that <bold>16</bold> had a scavenging potential against DPPH (IC<sub>50</sub> 159 μM) in comparison to PG (IC<sub>50</sub> 30 μM) and BHA, also had a powerful XO inhibitory potential (IC<sub>50</sub> 243 μM), in comparison to BHA (IC<sub>50</sub> 591 μM) and PG (IC<sub>50</sub> 628 μM), while <bold>2</bold> showed a weak XO inhibitory potential (IC<sub>50</sub> 707 μM) [<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]. Compounds <bold>47</bold>, <bold>50</bold>, and <bold>134</bold> exhibited no antioxidant capacities in the DPPH assay [<xref rid="B95-molecules-25-00395" ref-type="bibr">95</xref>]. However, <bold>90</bold> showed a moderate DPPH scavenging activity with an IC<sub>50</sub> 58 μg/mL, compared to BHA (IC<sub>50</sub> 5.5 μg/mL) [<xref rid="B96-molecules-25-00395" ref-type="bibr">96</xref>]. Compounds <bold>161</bold> and <bold>166</bold> scavenged DPPH with IC<sub>50</sub>s 23.4 and 16.4 μM, respectively in comparison to ascorbic acid (IC<sub>50</sub> 21.2 μM) [<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]. Furthermore, they prohibited the formation of superoxide anion radical with IC<sub>50</sub> values of 4.3 and 52.6 μM, respectively in the XXO assay in relation to allopurinol (IC<sub>50</sub> 3.0 μM), whereas <bold>165</bold> showed no radical scavenging activities [<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]. Moreover, they did not suppress the generation of superoxide anions induced by TPA in the differentiated HL-60 cells. Compounds <bold>160</bold>, <bold>165</bold>, and <bold>166</bold> showed excellent ORAC antioxidant activity (14.4, 10.8, and 11.5 ORAC units, respectively) [<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]. Pang et al. reported that <bold>172</bold>, <bold>173</bold>, and <bold>178</bold> possessed no radical scavenging activity against DPPH [<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]. The radical scavenging capacities of <bold>261</bold>–<bold>266</bold> were tested using DPPH. Only compounds <bold>261</bold> and <bold>263</bold> exhibited weak activity with EC<sub>50</sub>s 125.0 and 130.0 μM, respectively compared to vitamin C (EC<sub>50</sub> 35.0 μM) [<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]. The ability of compounds <bold>72</bold>, <bold>188</bold>, <bold>189</bold>, <bold>202</bold>–<bold>205</bold>, <bold>207</bold>–<bold>211</bold>, <bold>231</bold>, <bold>233</bold>, <bold>234</bold>, <bold>286</bold>, and <bold>287</bold> to regulate Nrf2, that complies to the oxidative stress by binding to ARE in the gene’s coding promoter for antioxidant enzymes and protein for the synthesis of glutathione using ARE-driven luciferase reporters in HepG2C8 cells was evaluated. Compounds <bold>209</bold>, <bold>210</bold>, and <bold>233</bold> (a dose 10 μM) produced a significant induction of luciferase 1.93–2.95 folds more than DMSO (blank control), whereas tBHQ (positive control) invigorated the luciferase activation with 4 folds more than DMSO at a dose (50 μM) [<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]. Compounds <bold>80</bold>, <bold>88</bold>, <bold>118</bold>, <bold>119</bold>, <bold>303</bold>, and <bold>307</bold> isolated from <italic>Penicillium coffeae</italic> were tested for their DPPH scavenging activities. Only <bold>302</bold> had a moderate effect (IC<sub>50</sub> 656 μM), compared to BHT (IC<sub>50</sub> 59 μM), whereas the rest compounds had no activities (IC<sub>50</sub> > 900 μM) [<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>].</p></sec><sec id="sec5dot4-molecules-25-00395"><title>5.4. α-Glucosidase, Acetylcholinesterase (AChE), and Protein Kinase Inhibitory Activities</title><p>α-Glucosidase is a carbohydrase, which is secreted from the epithelium of the small intestine [<xref rid="B97-molecules-25-00395" ref-type="bibr">97</xref>,<xref rid="B98-molecules-25-00395" ref-type="bibr">98</xref>]. It catalyzes the degradation of carbohydrates into α-glucose thus elevating the blood glucose level [<xref rid="B99-molecules-25-00395" ref-type="bibr">99</xref>,<xref rid="B100-molecules-25-00395" ref-type="bibr">100</xref>]. One of the therapeutic approaches for treating diabetes is to retard glucose absorption via inhibiting this enzyme. <italic>α</italic>-Glucosidase inhibitors slow down the digestion and absorption of carbohydrates by competitive blocking of the <italic>α</italic>-glucosidase activity [<xref rid="B101-molecules-25-00395" ref-type="bibr">101</xref>]. Consequently, the postprandial blood glucose concentration is reduced [<xref rid="B99-molecules-25-00395" ref-type="bibr">99</xref>,<xref rid="B100-molecules-25-00395" ref-type="bibr">100</xref>,<xref rid="B101-molecules-25-00395" ref-type="bibr">101</xref>]. Therefore, many efforts have been made to identify α-glucosidase inhibitors from natural sources.</p><p>Compounds <bold>54</bold>, <bold>64</bold>–<bold>66</bold>, <bold>84</bold>, <bold>92</bold>–<bold>95</bold>, <bold>150</bold>, <bold>158</bold>, <bold>159</bold>, <bold>212</bold>, <bold>213</bold>, <bold>216</bold>, and <bold>217</bold> were tested for the α-glucosidase inhibitory capacity [<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]. Compounds <bold>84</bold>, <bold>95</bold>, <bold>93</bold>, and <bold>212</bold> exhibited promising inhibitory activities (IC<sub>50</sub>s 89.4, 17.2, 36.4, and 38.1 μM, respectively), better than acarbose (IC<sub>50</sub> 958.3 μM). The activity of <bold>150</bold>, <bold>213</bold>, <bold>216</bold>, and <bold>217</bold> was five-fold more than that of acarbose. Compounds <bold>65</bold>, <bold>94</bold>, <bold>66</bold>, <bold>159</bold>, and <bold>158</bold> displayed moderate inhibitory activity with IC<sub>50s</sub> 315.3, 302.6, 417.8, 266.3, and 431.4 μM, respectively. Moreover, <bold>54</bold>, <bold>65</bold>, and <bold>66</bold> had weak activity, whereas the other isocoumarins had activities similar to that of acarbose [<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]. Compounds <bold>114</bold> and <bold>115</bold> biosynthesized by <italic>Aspergillus</italic> sp. were assessed for their in vitro α-glucosidase inhibitory capacities. Compound <bold>114</bold> exhibited more efficacy than that of acarbose (IC<sub>50</sub> 553.7 μM) with IC<sub>50</sub> 90.4 μM, whereas <bold>115</bold> was moderately active [<xref rid="B38-molecules-25-00395" ref-type="bibr">38</xref>]. The new isocoumarins, <bold>261</bold>–<bold>266</bold> were assessed for the α-glucosidase inhibitory potential in comparison to acarbose (IC<sub>50</sub> of 628.3 μM) [<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]. Compounds <bold>262</bold>, <bold>265</bold>, and <bold>266</bold> showed moderate inhibitory effects with IC<sub>50</sub>s 87.8, 52.3, and 95.6 μM, respectively [<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]. Cui et al. reported that <bold>203</bold>, <bold>205</bold>, and <bold>206</bold> had a moderate inhibitory activity with IC<sub>50</sub>s 343.7, 392.5, and 538.7 μM, respectively, compared to acarbose (IC<sub>50</sub> 815.3 μM) [<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>]. The α-glucosidase inhibitory capacities of <bold>204</bold>, <bold>222</bold>–<bold>230</bold>, <bold>258</bold>, <bold>267</bold>, and <bold>268</bold> which were biosynthesized by <italic>Penicillium commune</italic> were evaluated. Compounds <bold>224</bold>, <bold>225</bold>, <bold>227</bold>, and <bold>228</bold> possessed powerful activity (IC<sub>50</sub> 38.1–78.1 μM) than acarbose (IC<sub>50</sub> 478.4 μM). However, compounds <bold>204</bold>, <bold>223</bold>, and <bold>224</bold> were moderately active (IC<sub>50</sub>s 102.4–158.4 μM) [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]. Compound <bold>103</bold> which was separated from <italic>Xylariaceae</italic> sp. isolated from <italic>Quercus gilva</italic> stem, possessed α-glucosidase inhibitory potential with IC<sub>50</sub> 41.75 μg/mL, compared to quercetin (IC<sub>50</sub> 4.80 μg/mL) [<xref rid="B102-molecules-25-00395" ref-type="bibr">102</xref>]. The in vitro glucose consumption assay of <bold>78</bold> and <bold>79</bold> (Conc. 20 μg/mL) showed no activity with DMEM-induced 3T3 fibroblasts in the anti-diabetic model [<xref rid="B54-molecules-25-00395" ref-type="bibr">54</xref>]. The α-glucosidase inhibitory activity of <bold>76</bold>, <bold>81, 82, 85</bold>–<bold>88</bold>, <bold>93</bold>, and <bold>95</bold> which are reported from <italic>Myrothecium</italic> sp. was investigated. Compounds <bold>76</bold>, <bold>81</bold>, <bold>85</bold>, and <bold>87</bold> exhibited inhibitory potential towards the <italic>Saccharomyces cerevisiae</italic> expressed human-sourced α-glucosidase recombinant with IC<sub>50</sub>s 0.37, 0.32, 0.036, and 0.026 mM, respectively compared to acarbose (IC<sub>50</sub> 0.47 mM) [<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]. Compounds <bold>165</bold>, <bold>167</bold>, <bold>174</bold>, and <bold>218</bold> biosynthesized by <italic>Leptosphaena maculans</italic> did not show any inhibitory effects against α-glucosidase [<xref rid="B104-molecules-25-00395" ref-type="bibr">104</xref>]. </p><p>Acetylcholinesterase (AChE), an enzyme that catalyzes acetylcholine (ACh) hydrolysis leading to a decrease in the levels of ACh in the brain [<xref rid="B105-molecules-25-00395" ref-type="bibr">105</xref>]. Thus, appears to be a critical element in the development of neurodegenerative diseases such as Alzheimer’s disease (AD) and dementia. The most suitable therapeutic approach for treating AD and other forms of dementia is to restore ACh levels by inhibiting AChE [<xref rid="B106-molecules-25-00395" ref-type="bibr">106</xref>]. Compounds <bold>3</bold>, <bold>6</bold>, and <bold>8</bold> were evaluated for their AChE inhibitory activities. Compound <bold>6</bold> had a moderate AChE inhibitory potential with a limit of detection 30.0 μg, whereas <bold>3</bold> and <bold>8</bold> were inactive (limit of detection over 100 μg) [<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>]. Compounds <bold>34</bold>, <bold>36</bold>, and <bold>37</bold> showed weak inhibition of AChE with a limit of detection 10 μg in a TLC-based AChE inhibition assay [<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]. Only <bold>34</bold> displayed moderate AChE inhibitory activity (limit of detection 3.0 μg) compared to galantamine (MICs 1.0 μg) [<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]. </p><p>Protein kinases are enzymes that catalyze the transfer of a phosphate group from a high energy molecule such as adenine triphosphate (ATP) to a specific amino acid. They play important roles in regulating many cellular functions, including survival, proliferation, motility, apoptosis, as well as DNA damage repair and metabolism [<xref rid="B107-molecules-25-00395" ref-type="bibr">107</xref>]. Some of them are commonly activated in cancer cells and known to play roles in tumorigenesis [<xref rid="B108-molecules-25-00395" ref-type="bibr">108</xref>]. Protein kinases inhibitors are anticipated to be a source of potential therapeutic targets for treating various human disorders such as neoplastic and neuroinflammatory diseases [<xref rid="B107-molecules-25-00395" ref-type="bibr">107</xref>,<xref rid="B108-molecules-25-00395" ref-type="bibr">108</xref>]. The isolated alternariol derivatives from <italic>Alternaria</italic> sp. were assessed for their inhibitory activities against 24 protein kinases. Interestingly, alternariol (<bold>188</bold>) and its derivatives <bold>189</bold>–<bold>191</bold> prohibited protein kinases: Aurora A, ARK5, Aurora B, IGF1-R, b-RAF, VEGF-R2, FLT3, VEGF-R3, SAK, and PDGF-Rbeta with IC<sub>50</sub> below 1 × 10<sup>−6</sup> g/mL. Moreover, <bold>193</bold> exhibited activity with an IC<sub>50</sub> 1 × 10<sup>−5</sup> g/mL or less towards the various tested kinases [<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>].</p></sec><sec id="sec5dot5-molecules-25-00395"><title>5.5. Anti-Inflammatory Activity</title><p>Compounds <bold>3</bold>, <bold>88</bold>, <bold>131</bold>, <bold>165</bold>, and <bold>293</bold> were assessed for their COX-2 inhibitory activities. Only 293 exhibited significant inhibitory activity with an IC<sub>50</sub> 6.51 μM [<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]. The anti-inflammatory activities of <bold>203</bold>, <bold>208</bold>, <bold>220</bold>, <bold>221</bold>, <bold>231</bold>, <bold>288</bold>, <bold>289</bold>, <bold>291</bold>, and <bold>292</bold> were assessed against NO production in the LPS-stimulated mouse macrophage RAW 264.7 [<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]. Compound <bold>292</bold> had a potent inhibitory capacity (IC<sub>50</sub> 15.8 µM), whereas <bold>220</bold>, <bold>221</bold>, and <bold>291</bold> were weakly active compared to indomethacin (IC<sub>50</sub> 37.5 µM), while the other compounds had no inhibitory potential (IC<sub>50</sub> > 100 µM) [<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]. Annulohypoxylomarin A (7) derived from the endophytic fungus <italic>A. truncatum</italic> did not affect (IC<sub>50</sub> > 100 μM) the production of TNF-α, IL-12 p40, and IL-6 in LPS-stimulated bone marrow-derived dendritic cells [<xref rid="B45-molecules-25-00395" ref-type="bibr">45</xref>]. Compounds <bold>186</bold>, <bold>187</bold>, <bold>244</bold>, <bold>245</bold>, and <bold>248</bold> did not affect the NO production in LPS-induced RAW 246.7 mouse macrophages [<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]. Compounds <bold>19</bold> and <bold>36</bold> biosynthesized by <italic>Xylaria cubensis</italic> associated with <italic>Litsea akoensis</italic> leaves were assessed for their capacities to prohibit IL-6 and NO production in LPS-activated RAW 264.7 cells. It is noteworthy that <bold>36</bold> had IL-6 inhibitory potential with IC<sub>50</sub> 9.4 μM [<xref rid="B109-molecules-25-00395" ref-type="bibr">109</xref>]. Compounds <bold>23</bold> and <bold>27</bold> had moderate inhibitory effects on the production NO in LPS-induced RAW 264.7 cells (IC<sub>50</sub> 26.3 and 38.7 µM, respectively) with no observed toxicities at 50 µM [<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]. </p></sec><sec id="sec5dot6-molecules-25-00395"><title>5.6. Anti-Mycobacterial, Antiplasmodial, Antiviral, and Insecticidal Activities</title><p>Compounds <bold>204</bold>, <bold>222</bold>–<bold>230</bold>, <bold>258</bold>, <bold>267</bold>, and <bold>268</bold> (Conc. 50 μM) were tested for their <italic>Mycobacterium</italic> protein tyrosine phosphatase B (MptpB) inhibitory activity [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]. Compound <bold>225</bold> had MptpB inhibitory effect (IC<sub>50</sub> 20.7 μM), compared to oleanolic acid (IC<sub>50</sub> 22.1 μM), however, the other compounds possessed weak or no inhibitory effects at the same concentration [<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]. Arunpanichlert et al. reported that compounds <bold>61</bold>, <bold>212</bold>, and <bold>213</bold> showed no activity against <italic>Mycobacterium tuberculosis</italic> [<xref rid="B41-molecules-25-00395" ref-type="bibr">41</xref>]. Compounds <bold>162</bold> and <bold>163</bold> showed weak antituberculous potential against <italic>M. tuberculosis</italic> H27Ra (IC<sub>50</sub>s 25 and 50 μg/mL, respectively), in comparison to kanamycin sulfate and isoniazid (IC<sub>50</sub>s 0.050 and 2.5 μg/mL, respectively) using MABA, whereas <bold>164</bold> had no activity [<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]. The antiplasmodial activity against the multidrug-resistant K1 strain of <italic>Plasmodium falciparum</italic> of <bold>165</bold> and <bold>168</bold> was estimated using microculture radioisotope technique [<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]. Compound <bold>165</bold> showed antiplasmodial activity (IC<sub>50</sub> 0.68 μM). However, its 11-hydroxy analog (<bold>168</bold>) had a 10-fold lower activity, suggesting that the existence of the OH group in the <italic>n</italic>-propyl chain decreases the activity [<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]. Compounds <bold>61</bold>, <bold>212</bold>, and <bold>213</bold> had no antimalarial activity towards <italic>P. falciparum</italic> [<xref rid="B41-molecules-25-00395" ref-type="bibr">41</xref>]. Furthermore, <bold>6</bold> and <bold>35</bold> had no antimalarial potential against K1 strain of <italic>P. falciparum</italic> [<xref rid="B110-molecules-25-00395" ref-type="bibr">110</xref>,<xref rid="B111-molecules-25-00395" ref-type="bibr">111</xref>]. Compounds <bold>98</bold>, <bold>99</bold>, <bold>276</bold>–<bold>285</bold>, and <bold>294</bold> were tested for in vitro activity against <italic>Tritrichomonas fetus</italic> (KV-1). The results revealed that <bold>283</bold>–<bold>285</bold> displayed weak to moderate activity, whereas the other metabolites had no activity [<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]. Compounds <bold>162</bold> and <bold>163</bold> showed significant antimalarial potential with IC<sub>50</sub>s 4.7 and 2.6 μg/mL, respectively, compared to chloroquine diphosphate (IC<sub>50</sub> 0.16 μg/mL) towards <italic>P. falciparum</italic> (K1, multi-drug resistant strain) using microculture radioisotope technique [<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]. However, <bold>163</bold> was inactive [<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]. Compound <bold>11</bold> separated from the endophytic fungus <italic>Phoma</italic> sp. exhibited antiviral activity against influenza A virus (A/Puerto Rico/8/34, H1N1) with IC<sub>50</sub> 20.98 µg/mL, compared to arbidol (IC<sub>50</sub> 0.15 µg/mL) [<xref rid="B26-molecules-25-00395" ref-type="bibr">26</xref>]. The anti-tobacco mosaic virus (anti-TMV) activities <bold>39</bold>, <bold>67</bold>–<bold>69</bold>, <bold>96</bold>, <bold>97</bold>, and <bold>137</bold> (Conc. 20 μM) produced by <italic>P. oxalicum</italic>, isolated from <italic>Nicotiana sanderae</italic> leaves was screened using the half-leaf method [<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]. The results showed that <bold>67</bold> had the highest activity (% inhibition 25.4). While other compounds possessed weak activity with an inhibition rate ranging from 11.3 to 18.9% [<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]. Duan et al. mentioned that <bold>40</bold> and <bold>41</bold> (Conc. 20 μM) had anti-TMV capacities (inhibition rates 18.6 and 21.8%, respectively) using the half-leaf technique [<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]. The anti-TMV activities of <bold>38</bold>, <bold>52, 53</bold>, <bold>127</bold>, <bold>137</bold>, <bold>251</bold>, and <bold>301</bold> were evaluated using the half-leaf method at a concentration 20 μM. Interestingly, <bold>251</bold> showed a high anti-TMV potential (inhibition rate 28.6%), compared to ningnanmycin (inhibition rate 31.5%), whereas the other metabolites had a moderate activity (inhibition rates 15.6–22.0%) [<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]. Oryzaeins A (<bold>111</bold>) and B (<bold>112</bold>), new isocoumarin derivatives isolated from Aspergillus oryzae were tested for their anti-TMV utilizing the half-leaf assay at Conc. 20 µM. The results revealed that <bold>111</bold> and <bold>112</bold> had moderate anti-TMV potential (inhibition rates 28.4 and 30.6%, respectively) [<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]. Antifeedant activities of <bold>134</bold> and <bold>135</bold> were evaluated against larvae of <italic>Spodoptera littoralis</italic> using glass-fiber discs. Compound <bold>135</bold> possessed activity at 100 ppm with feeding index 42.1, whereas <bold>134</bold> did not affect the feeding (feeding index 30.1) [<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]. The new isocoumarins, <bold>186</bold>, <bold>187</bold>, <bold>244</bold>, <bold>245</bold>, and <bold>248</bold> displayed a growth inhibitory activity toward <italic>Helicoverpa armigera Hubner</italic> (IC<sub>50</sub>s 200, 200, 200, 100, and 100, μg/mL, respectively), compared to azadirachtin (IC<sub>50</sub> 25 μg/mL) [<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>].</p></sec><sec id="sec5dot7-molecules-25-00395"><title>5.7. Other Biological Activities</title><p>The antischistosomal activity of <bold>6</bold> and <bold>35</bold> was estimated against <italic>Schistosoma mansoni</italic> adult worms. It is noteworthy that <bold>6</bold> and <bold>35</bold> (Conc. 50 and 200 μg/mL, respectively) caused 100% death of the parasites, compared to praziquantel (Conc. 12.5 μg/mL) [<xref rid="B113-molecules-25-00395" ref-type="bibr">113</xref>]. Compounds <bold>6</bold> and <bold>131</bold> produced by <italic>Neofusicoccum parvum,</italic> showed phytotoxic activity on tomato plants with symptoms ranging from slight to drastic wilting of leaves [<xref rid="B114-molecules-25-00395" ref-type="bibr">114</xref>]. Nakashima et al. reported that <bold>87</bold>, <bold>109</bold>, <bold>148</bold>, and <bold>149</bold> isolated from <italic>Houttuynia cordata</italic> leaves associated fungus <italic>Tubakia</italic> sp. ECN-111 had no agonistic activity for a liver X-receptor and peroxisome proliferator-activated receptor-C in a luciferase reporter gene assay [<xref rid="B115-molecules-25-00395" ref-type="bibr">115</xref>]. Compounds <bold>160</bold>, <bold>161</bold>, <bold>165</bold>, and <bold>166</bold> did not prohibit aromatase (CYP19) enzyme (IC<sub>50</sub> 15.3–16.9 μM) [<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]. Compound <bold>300</bold> produced by <italic>Penicillium</italic> sp. possessed moderate inhibitory activity on the <italic>Arabidopsis thaliana</italic> seeds germination [<xref rid="B116-molecules-25-00395" ref-type="bibr">116</xref>].</p></sec></sec><sec sec-type="conclusions" id="sec6-molecules-25-00395"><title>6. Conclusions </title><p>Endophytic fungi have been emerged as a new area for the discovery of new pharmaceutical candidates and continue to be a prosperous pool of bioactive and structurally unique metabolites. The isocoumarins and 3,4-dihydroisocoumarins ring system is present in nature with an enormous spectrum of bioactivities, extending from antibacterial to anticancer. According to this review, the distinctive pharmacological significance of these metabolites initiates much research to be done and still going on towards the advancement and synthesis of their derivatives. The inactivity reported for some derivatives in former studies could be due to prejudice in the evaluation experiments. Further assessments of these metabolites with wider spectrum screening systems are endorsed, which may lead to the invention of their interesting activities.</p></sec></body><back><notes><title>Author Contributions</title><p>S.R.M.I., G.A.M., S.G.A.M., H.M.A.: developed the concept for the review, wrote manuscript, and original draft preparation; A.O.N., D.M.A., A.A.B.: contributed literature search and data curation and funding acquisition: S.R.M.I., G.A.M., S.G.A.M., H.M.A.: read and approved the final manuscript. All authors have read and agreed to the published version of the manuscript.</p></notes><notes><title>Funding</title><p>This research received no external funding.</p></notes><notes notes-type="COI-statement"><title>Conflicts of Interest</title><p>The authors declare no conflict of interest.</p></notes><glossary><title>Abbreviations</title><p>1D: One Dimensional; 2D: Two Dimensional; A2780: Human Ovarian Cancer Cell Line; A375-S2: Human Malignant Melanoma Cell Line; A375-C5: Human Malignant Melanoma IL-1 Insensitive; A549: Human Lung Carcinoma Cell Line; AChE; Acetylcholinesterase; AGS; Gastric Adenocarcinoma Cell Line; ARE: Antioxidant Response Element; ARK5: NUAK Family SNF1-Like Kinase 1; ASPC-1: Pancreatic Adenocarcinoma Cell Line; Aurora A: Aurora A Kinase: Aurora B: Aurora B Kinase; BFHEnz: Bifunctional Hybrid Enzyme; BGC823: Kind of Human Gastric Carcinoma Cell Line; BHA: 3-<italic>t</italic>-Butyl-4-Hydroxyanisole; BHT: Butylated Hydroxytoluene; b-RAF: Proto-oncogene, Serine/Threonine Kinase; BT474: Breast Cancer Cell Line; CCK: Cholecystokinin; CD: Circular Dichroism; DPPH: 2,2-Diphenyl-1-picrylhydrazyl; CHCl<sub>3</sub>: Chloroform; CH<sub>2</sub>Cl<sub>2</sub>: Dichloromethane; CHAGO: Human Lung Bronchus Carcinoma Cell Line; COSY: Correlation Spectroscopy: COX-2: Cyclooxygenase-2; CPE: Cytopathic Effect; CYP19: Aromatase; DHICs: Dihydroisocoumarins; DMEM: Dulbecco’s Modified Eagle Medium; DMSO: Dimethyl Sulfoxide; DU145: Human Prostate Cancer Cell Line; EC<sub>50</sub>: Half Maximal Effective Concentration; EtOAc: Ethyl Acetate; FLT3: fms Related Tyrosine Kinase 3; GI: Growth Inhibition; H460: Human Lung Cancer Cell Line; HCT 116: Human Colon Cancer Cell Line; HeLa: Human Cervix Carcinoma Cell Line; HEK293T: Human embryonic kidney Cell Line; HEP-1: Hepatoma Cancer cell line; HepG2: Liver Hepatocellular Carcinoma Cell Line; HL-60: Human Caucasian Promyelocytic Leukemia Cell Line; HMBC: Heteronuclear Multiple Bond Correlation; HSQC: Heteronuclear Single Quantum Coherence; HuCCA-1: Human Lung Cholangiocarcinoma Cell Line; HUVEC: Human Umbilical Vein Endothelial Cell Line; HUAEC: Human Umbilical Artery Endothelial Cells; IC: Inhibitory Concentration; IC<sub>50</sub>: The Half Maximal Inhibitory Concentration; IGF-1R: Insulin like Growth Factor 1 Receptor; IL-6: Interleukin 6; IL-12 p40: Interleukin-12 Subunit Beta; IR: Infrared Radiation; IZD: Inhibition Zone Diameter; K562: Human Immortalised Myelogenous Leukemia Cell Line; KATO-3: Human Gastric Cancer; L5178Y: Mouse Lymphoma Cell Line; LPS: Lipopolysaccharide; LD: Lethal Dose; MABA; Microplate Alamar Blue Assay; MBC: Minimum Bactericidal Concentration; MCF-7: Human Breast Adenocarcinoma Cell Line; MCF10A: Immortalized Non-Cancer Breast Epithelial Cell Line; MDA-MB-435: Human Breast Cancer Cell Line; MeCN: Acetonitrile; MeOH: Methanol; MIC: Minimum Inhibitory Concentration; MIA-PACA-2: Pancreas Ductal Adenocarcinoma Cell Line; MOLT-3 and MOLT-4: Acute Lymphoblastic Leukemia Cell Line; Molm 13: Human Acute Myeloid Leukemia Cell Line; MptpB: Mycobacterium Protein Tyrosine Phosphatase B; MRC-5: Permanent Lung Fibroblast Cell Line; MRSA: Methicillin-Resistant <italic>Staphylococcus aureus</italic>: MS: Mass spectrometry; MTPA: α-Trifluoromethylphenylacetic Acid: MTS: One Solution Cell Proliferation; MTT: Microculture Tetrazolium Assay; NB4: Human Acute Promyelocytic Leukemia Cell line; NCIH460; Human Lung Cancer Cell Line; NMR: Nuclear Magnetic Resonance; NO: Nitric Oxide; NOE: Nuclear Overhauser Effect; NOESY; Nuclear Overhauser Effect Spectroscopy; Nrf2: Nuclear Factor E2-Related Factor 2; ORAC: Oxygen Radical Absorbance Capacity; PC-12: Adrenal Phaeochromocytoma Cell Line; PC-3: Human Prostate Cancer Cell Line; PDGF-Rbeta: Platelet-Derived Growth Factor Receptor Beta; PE: Petroleum Ether; PG: Propyl Gallate; PI: Partial Inhibition; PKS: Polyketide Synthetase; RAW 264.7: Mouse Macrophage; ROESY: Rotating Frame Nuclear Overhauser Effect Correlation Spectroscopy; RP-18: Reversed Phase C-18; SAK: Staphylokinase; SAM: S-Adenosyl Methionine; SMMC-7721: Hepatocellular Carcinoma Cell line; SGC-7901: Human Gastric Cancer Cell Line; SHSY5Y: Neuroblastoma Cell Line; SiO<sub>2</sub> CC: Silica gel Column Chromatography; SW-620: Human Caucasian Colon Adenocarcinoma Cell Line; SW-480: Colorectal Adenocarcinoma Cell Line; TBHQ: Tertiary Butylhydroquinone; THP-1: Human Monocytic Cancer Cell Line; TMV: Tobacco Mosaic Virus; TNF-α: Tumor Necrosis Factor Alpha; TPA: 12-<italic>O</italic>-Tetradecanoylphorbol-13-Acetate; TLC: Thin Layer Chromatography; U2OS: Human Osteosarcoma Cell Line; U937: Human Macrophage (Mφ) Cancer Cell Line; UV: Ultraviolet; VEGF-R2: Vascular Endothelial Growth Factor A: VEGF-R3: Vascular Endothelial Growth Factor 3; VLC: Vacuum Liquid Chromatography; XO: Xanthine Oxidase; XXO: Xanthine/Xanthine Oxidase.</p></glossary><ref-list><title>References</title><ref id="B1-molecules-25-00395"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ibrahim</surname><given-names>S.R.</given-names></name><name><surname>Abdallah</surname><given-names>H.M.</given-names></name><name><surname>Mohamed</surname><given-names>G.A.</given-names></name><name><surname>Ross</surname><given-names>S.A.</given-names></name></person-group><article-title>Integracides HJ: New tetracyclic triterpenoids from the endophytic fungus <italic>Fusarium</italic> sp.</article-title><source>Fitoterapia</source><year>2016</year><volume>112</volume><fpage>161</fpage><lpage>167</lpage><pub-id pub-id-type="doi">10.1016/j.fitote.2016.06.002</pub-id><pub-id pub-id-type="pmid">27282207</pub-id></element-citation></ref><ref id="B2-molecules-25-00395"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ibrahim</surname><given-names>S.R.</given-names></name><name><surname>Mohamed</surname><given-names>G.A.</given-names></name><name><surname>Khedr</surname><given-names>A.I.</given-names></name></person-group><article-title>γ-Butyrolactones from <italic>Aspergillus</italic> species: Structures, biosynthesis, and biological activities</article-title><source>Nat. 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8</label><caption><p>Structures of isocoumarin derivatives <bold>67</bold>–<bold>82</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g008"></graphic></fig><fig id="molecules-25-00395-f009" orientation="portrait" position="float"><label>Figure 9</label><caption><p>Structures of isocoumarin derivatives <bold>83</bold>–<bold>96</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g009"></graphic></fig><fig id="molecules-25-00395-f010" orientation="portrait" position="float"><label>Figure 10</label><caption><p>Structures of isocoumarin derivatives <bold>97</bold>–<bold>105</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g010"></graphic></fig><fig id="molecules-25-00395-f011" orientation="portrait" position="float"><label>Figure 11</label><caption><p>Structures of isocoumarin derivatives <bold>106</bold>–<bold>113</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g011"></graphic></fig><fig id="molecules-25-00395-f012" orientation="portrait" position="float"><label>Figure 12</label><caption><p>Structures of isocoumarin derivatives <bold>114</bold>–<bold>123</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g012"></graphic></fig><fig id="molecules-25-00395-f013" orientation="portrait" position="float"><label>Figure 13</label><caption><p>Structures of isocoumarin derivatives <bold>124</bold>–<bold>136</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g013"></graphic></fig><fig id="molecules-25-00395-f014" orientation="portrait" position="float"><label>Figure 14</label><caption><p>Structures of isocoumarin derivatives <bold>137</bold>–<bold>149</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g014"></graphic></fig><fig id="molecules-25-00395-f015" orientation="portrait" position="float"><label>Figure 15</label><caption><p>Structure of isocoumarin derivatives <bold>150</bold>–<bold>159</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g015"></graphic></fig><fig id="molecules-25-00395-f016" orientation="portrait" position="float"><label>Figure 16</label><caption><p>Structures of isocoumarin derivatives <bold>160</bold>–<bold>164</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g016"></graphic></fig><fig id="molecules-25-00395-f017" orientation="portrait" position="float"><label>Figure 17</label><caption><p>Structures of isocoumarin derivatives <bold>165</bold>–<bold>174</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g017"></graphic></fig><fig id="molecules-25-00395-f018" orientation="portrait" position="float"><label>Figure 18</label><caption><p>Structures of isocoumarin derivatives <bold>175</bold>–<bold>182</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g018"></graphic></fig><fig id="molecules-25-00395-f019" orientation="portrait" position="float"><label>Figure 19</label><caption><p>Structures of isocoumarin derivatives <bold>183</bold>–<bold>187</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g019"></graphic></fig><fig id="molecules-25-00395-f020" orientation="portrait" position="float"><label>Figure 20</label><caption><p>Structures of isocoumarin derivatives <bold>188</bold>–<bold>200</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g020"></graphic></fig><fig id="molecules-25-00395-f021" orientation="portrait" position="float"><label>Figure 21</label><caption><p>Structures of isocoumarin derivatives <bold>201</bold>–<bold>211</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g021"></graphic></fig><fig id="molecules-25-00395-f022" orientation="portrait" position="float"><label>Figure 22</label><caption><p>Structures of isocoumarin derivatives <bold>212</bold>–<bold>228</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g022"></graphic></fig><fig id="molecules-25-00395-f023" orientation="portrait" position="float"><label>Figure 23</label><caption><p>Structures of isocoumarin derivatives <bold>229</bold>–<bold>239</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g023"></graphic></fig><fig id="molecules-25-00395-f024" orientation="portrait" position="float"><label>Figure 24</label><caption><p>Structures of isocoumarin derivatives <bold>240</bold>–<bold>250</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g024"></graphic></fig><fig id="molecules-25-00395-f025" orientation="portrait" position="float"><label>Figure 25</label><caption><p>Structures of isocoumarin derivatives <bold>251</bold>–<bold>264</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g025"></graphic></fig><fig id="molecules-25-00395-f026" orientation="portrait" position="float"><label>Figure 26</label><caption><p>Structures of isocoumarin derivatives <bold>265</bold>–<bold>272</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g026"></graphic></fig><fig id="molecules-25-00395-f027" orientation="portrait" position="float"><label>Figure 27</label><caption><p>Structures of isocoumarin derivatives <bold>273</bold>–<bold>279</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g027"></graphic></fig><fig id="molecules-25-00395-f028" orientation="portrait" position="float"><label>Figure 28</label><caption><p>Structures of isocoumarin derivatives <bold>280</bold>–<bold>294</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g028"></graphic></fig><fig id="molecules-25-00395-f029" orientation="portrait" position="float"><label>Figure 29</label><caption><p>Structures of isocoumarin derivatives <bold>295</bold>–<bold>300</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g029"></graphic></fig><fig id="molecules-25-00395-f030" orientation="portrait" position="float"><label>Figure 30</label><caption><p>Structures of isocoumarin derivatives <bold>301</bold>–<bold>307</bold>.</p></caption><graphic xlink:href="molecules-25-00395-g030"></graphic></fig><fig id="molecules-25-00395-f031" orientation="portrait" position="float"><label>Figure 31</label><caption><p>Proposed biosynthetic pathway of <bold>11</bold>, <bold>35</bold>, <bold>88</bold>, <bold>90</bold>, and <bold>165</bold> [<xref rid="B21-molecules-25-00395" ref-type="bibr">21</xref>,<xref rid="B23-molecules-25-00395" ref-type="bibr">23</xref>,<xref rid="B24-molecules-25-00395" ref-type="bibr">24</xref>,<xref rid="B25-molecules-25-00395" ref-type="bibr">25</xref>,<xref rid="B26-molecules-25-00395" ref-type="bibr">26</xref>].</p></caption><graphic xlink:href="molecules-25-00395-g031"></graphic></fig><fig id="molecules-25-00395-f032" orientation="portrait" position="float"><label>Figure 32</label><caption><p>Proposed biosynthetic pathway of <bold>56</bold> and <bold>125</bold> [<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>].</p></caption><graphic xlink:href="molecules-25-00395-g032"></graphic></fig><fig id="molecules-25-00395-f033" orientation="portrait" position="float"><label>Figure 33</label><caption><p>Proposed biosynthetic pathway of <bold>273</bold> [<xref rid="B28-molecules-25-00395" ref-type="bibr">28</xref>].</p></caption><graphic xlink:href="molecules-25-00395-g033"></graphic></fig><fig id="molecules-25-00395-f034" orientation="portrait" position="float"><label>Figure 34</label><caption><p>Proposed biosynthetic pathway of <bold>70</bold>, <bold>71</bold>, <bold>138</bold>, <bold>179</bold>, and <bold>180</bold> [<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>].</p></caption><graphic xlink:href="molecules-25-00395-g034"></graphic></fig><fig id="molecules-25-00395-f035" orientation="portrait" position="float"><label>Figure 35</label><caption><p>Proposed biosynthetic pathway of <bold>235</bold>, <bold>236</bold>, and <bold>296</bold> [<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>].</p></caption><graphic xlink:href="molecules-25-00395-g035"></graphic></fig><table-wrap id="molecules-25-00395-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">molecules-25-00395-t001_Table 1</object-id><label>Table 1</label><caption><p>List of fungal isocoumarins (Fungal source, host, and place).</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Compound Name</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Fungus</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Host (Part, Family)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Source, Place</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">References</th></tr></thead><tbody><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kigelin (<bold>1</bold>)<break></break>(−)-(3R)-6,7-Dimethoxymellein </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus terrus</italic> BDKU 1164</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mubarak village beach, Karachi, Pakistan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R,4R)-6,7-Dimethoxy-4-hydroxymellein (<bold>2</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus terrus</italic> BDKU 1164</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mubarak village beach, Karachi, Pakistan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">8-Methoxymellein (<bold>3</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp.1 and sp.2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alibertia macrophylla</italic> (Leaves, Rubiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mogi-Guaçu, São Paulo, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria</italic> sp. KcF6</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daya Bay, Shenzhen, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria cubensis</italic> BCRC 09F 0035</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Litsea akoensis</italic> Hayata (Leaves, Lauraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kaohsiung, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B109-molecules-25-00395" ref-type="bibr">109</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cis-4-Acetoxyoxymellein (<bold>4</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycete</italic> 6650</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Meliotus dentatus</italic> (Leaves, Fabaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Baltic Sea, Ahrenshoop, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8-Deoxy-6-hydroxy-<italic>cis</italic>-4-acetoxyoxymellein (<bold>5</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycete</italic> 6650</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Meliotus dentatus</italic> (Leaves, Fabaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Baltic Sea, Ahrenshoop, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td rowspan="8" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4R)-(−)-4-Hydroxymellein<break></break>(3R,4R)-Cis-4-Hydroxymellein (<bold>6</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus terrus</italic> (BDKU 1164)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mubarak village beach, Karachi, Pakistan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria</italic> sp. PBR-30</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sandoricum koetjape</italic> (Leaves, Meliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Prachinburi Province, Thailand </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B111-molecules-25-00395" ref-type="bibr">111</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascochyta</italic> sp. </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Meliotus dentatus</italic> (Whole plant, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shores of the Baltic Sea, near Ahrenshoop, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B117-molecules-25-00395" ref-type="bibr">117</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. PSU-N24</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia nigrolineata</italic> (Branches, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ton Nga Chang wildlife sanctuary, Songkhla province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B110-molecules-25-00395" ref-type="bibr">110</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Neofusicoccum parvum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Vitis vinifera</italic> L. (Cankered branchs, Vitaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Catalonia, NE Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B114-molecules-25-00395" ref-type="bibr">114</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Emericellopsis minima</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Hyrtios erecta</italic> (Marine sponge)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Similan islands, Phag Nga Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B92-molecules-25-00395" ref-type="bibr">92</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apiospora montagnei</italic> Sacc.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Smallanthus sonchifolius</italic> (Roots, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ribeirão Preto city, S. P. State, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B113-molecules-25-00395" ref-type="bibr">113</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Annulohypoxylomarin (<bold>7</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Annulohypoxylon truncatum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Zizania caduciflora</italic> (Leaves, Poaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Suncheon, South Korea</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B45-molecules-25-00395" ref-type="bibr">45</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">5-Hydroxymellein (<bold>8</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp.1 and sp.2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alibertia macrophylla</italic> (Leaves, Rubiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mogi-Guaçu, São Paulo, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-6-Methoxy-7-chloromellein (<bold>9</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. 135 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ectyplasia perox</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lauro Club Reef, Dominica </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B32-molecules-25-00395" ref-type="bibr">32</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R,4R)-Cis-4-Hydroxy-5-methylmellein (<bold>10</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified <italic>Ascomycete</italic> 6650</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Meliotus dentatus</italic> (Leaves, Fabaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Baltic Sea, Ahrenshoop, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B43-molecules-25-00395" ref-type="bibr">43</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(−)-6-Methoxymellein (<bold>11</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. YE3135</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aconitum vilmorinianum</italic> (Roots, Ranunculaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yunnan University, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B26-molecules-25-00395" ref-type="bibr">26</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R,4S)-4-Hydroxy-6-methoxy-7-chloromellein (<bold>12</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. 135 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ectyplasia perox</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lauro Club Reef, Dominica </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B32-molecules-25-00395" ref-type="bibr">32</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryospyrone C (<bold>13</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria ramosa</italic> L29</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Leaves, Scrophulariaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryospyrone D (<bold>14</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria ramosa</italic> L29</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Leaves, Scrophulariaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3R-(+)-5-<italic>O</italic>-[6′-<italic>O</italic>-Acetyl]-α-D-glucopyranosyl-5-hydroxymellein (<bold>15</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria</italic> sp. cfcc 87468</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pinus tabuliformis</italic> (Leaves, Pinaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">China Forestry Culture Collection Center, Beijing, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B118-molecules-25-00395" ref-type="bibr">118</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-(4′-Hydroxy-2′-methyl phenoxy)-(−)-(3R)-mellein (<bold>16</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus terrus</italic> BDKU 1164</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mubarak village beach, Karachi, Pakistan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R)-7-Hydroxy-5-methylmellein (<bold>17</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Biscogniauxia capnodes</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Averrhoa carambola</italic> L. (Fruits, Oxalidaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Home garden in Kandy, Central Province, Sri Lanka </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B96-molecules-25-00395" ref-type="bibr">96</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Akolitserin (<bold>18</bold>) <break></break>(+)-(3R,4S)-5-Carbomethoxy-3-hydroxymellein <break></break>Methyl (3R,4S)-3,4-Dihydro-4,8-dihydroxy-3-methyl-1-oxo-1H-isochromene-5-carboxylate</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria cubensis</italic> BCRC 09F 0035</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Litsea akoensis</italic> Hayata (Leaves, Lauraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kaohsiung, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B109-molecules-25-00395" ref-type="bibr">109</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(−)-(R)-5-(Methoxycarbonyl)mellein (<bold>19</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria cubensis</italic> BCRC 09F 0035</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Litsea akoensis</italic> Hayata (Leaves, Lauraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kaohsiung, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B109-molecules-25-00395" ref-type="bibr">109</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R*,4S*)-6,8-Dihydroxy-3,4,7-trimethylisocoumarin (<bold>20</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. 091402</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Qinglan Port, Hainan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B87-molecules-25-00395" ref-type="bibr">87</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4S)-6,8-Dihydroxy-3,4,5,7-tetramethylisochroman (<bold>21</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. 091402</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Qinglan Port, Hainan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B87-molecules-25-00395" ref-type="bibr">87</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R,4R)-5-Cholro-4,6-dihydroxymellein (<bold>22</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone A (<bold>23</bold>)<break></break>(R)-5-Bromo-6-hydroxy-8-methoxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone B (<bold>24</bold>)<break></break>(R)-7-Bromo-6-hydroxy-8-methoxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone C (<bold>25</bold>)<break></break>(R)-7-Bromo-6,8-dimethoxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone D (<bold>26</bold>)<break></break>(R)-7-Bromo-6-hydroxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone E (<bold>27</bold>)<break></break>(R)-5-Bromo-6,7-dihydroxy-8-methoxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone F (<bold>28</bold>)<break></break>(R)-5-Cholro-6-hydroxy-8-methoxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerone G (<bold>29</bold>)<break></break>(R)-7-Cholro-6-hydroxy-8-methoxy-mellein</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(R)-5-Cholro-6-hydroxymellein (<bold>30</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerin A (<bold>31</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerin B (<bold>32</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Palmaerin D (<bold>33</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R,4R)-3,4-Dihydro-4,6-dihydroxy-3-methyl-1-oxo-1H-isochromene-5-carboxylic acid (<bold>34</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xylaria sp. PA-01</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Piper aduncum</italic> (Leaves, Piperaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mogi-Guaçu, Săo Paulo, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td rowspan="8" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R)-Mellein (<bold>35</bold>)<break></break>3,4-Dihydro-(3R)-methyl-8-hydroxyisocoumarin</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Centraalbureau voor</italic> Schimmel 120379</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Picea glauca</italic> (Leaves, Pinaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sussex, New Brunswick, Canada</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-molecules-25-00395" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. PSU-N24</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia nigrolineata</italic> (Branches, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ton Nga Chang wildlife sanctuary, Songkhla province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-molecules-25-00395" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. LLGLM003</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Moringa oleifera</italic> (Roots, Moringaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xiamen municipality, Fujian Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B53-molecules-25-00395" ref-type="bibr">53</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apiospora montagnei</italic> Sacc.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Smallanthus sonchifolius</italic> (Roots, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ribeirão Preto city, S. P. State, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B113-molecules-25-00395" ref-type="bibr">113</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lasiodiplodia</italic> sp. ME4-2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Viscum coloratum</italic> (Flowers, Santalaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hangzhou City, Zhejiang Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B120-molecules-25-00395" ref-type="bibr">120</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sarcosomataceae</italic> sp. NO.49-14-2-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Everniastrum nepalense</italic> (Taylor) Hale ex Sipman (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Panzhihua, Sichuan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B121-molecules-25-00395" ref-type="bibr">121</xref>] </td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium janczewskii</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Prumnopitys andina</italic> (Phloem, Podocarpaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Western Andean slopes near Las Trancas, Chillan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B91-molecules-25-00395" ref-type="bibr">91</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(R)-7-Hydroxymellein (<bold>36</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. 05070032-C </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alibertia macrophylla</italic> (Leaves, Rubiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mogi-Guaçu, Săo Paulo, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria cubensis</italic> BCRC 09F 0035</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Litsea akoensis</italic> Hayata (Leaves, Lauraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kaohsiung, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B109-molecules-25-00395" ref-type="bibr">109</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R,4R)-4,7-Dihydroxymellein (<bold>37</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. 05070032-C</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alibertia macrophylla</italic> (Leaves, Rubiaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mogi-Guaçu, Săo Paulo, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Angelicoin A (<bold>38</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> 0456 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B122-molecules-25-00395" ref-type="bibr">122</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Periplanetin A (<bold>39</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-Methyl-8-hydroxy-6-(hydroxymethyl)-7-methoxydihydroisocoumarin (<bold>40</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana tabacum</italic> (Rhizomes, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chuxiong, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-Methyl-7,8-dimethoxy-6-(hydroxymethyl)<break></break>dihydro-isocoumarin (<bold>41</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana tabacum</italic> (Rhizomes, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chuxiong, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(R)-6-Hydroxymellein (<bold>42</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana tabacum</italic> (Rhizomes, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chuxiong, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Seltsamia galinsogisoli</italic> sp. nov. SYPF 7336</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Galinsoga parviflora</italic> (Whole plant, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Huludao, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B78-molecules-25-00395" ref-type="bibr">78</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dimethoxy-3-methyl-3,4-dihydro-1H-isochromen-1-one (<bold>43</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana tabacum</italic> (Rhizomes, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chuxiong, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Periplanetin B (<bold>44</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana tabacum</italic> (Rhizomes, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chuxiong, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Arundinone A (<bold>45</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Microsphaeropsis arundinis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ulmus macrocarpa</italic> (Stems, Ulmaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B123-molecules-25-00395" ref-type="bibr">123</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergillspin F (<bold>46</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. SCSIO 41501</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Melitodes squamata</italic> (Gorgonian, Plexauridae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, Sanya Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B70-molecules-25-00395" ref-type="bibr">70</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R)-5-Carbomethoxymellein (<bold>47</bold>)<break></break>5-Carbomethyoxy-3,4-dihydro-8-hydroxy-(3R)-methylisocoumarin </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Centra albureau voor</italic> Schimmel cultures 120379 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Picea glauca</italic> (Leaves, Pinaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sussex, New Brunswick, Canada</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-molecules-25-00395" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria</italic> sp. PSU-G12</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia hombroniana</italic> (Branch, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B95-molecules-25-00395" ref-type="bibr">95</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-5-Formylmellein (<bold>48</bold>)<break></break>3,4-Dihydro-5-formyl-8-hydroxy-(3R)-methylisocoumarin</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Centraalbureau voor</italic> Schimmel 120379 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Picea glauca</italic> (Leaves, Pinaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sussex, New Brunswick, Canada</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-molecules-25-00395" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xylarellein (<bold>49</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria</italic> sp. PSU-G12</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia hombroniana</italic> (Branch, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B95-molecules-25-00395" ref-type="bibr">95</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-5-Carboxylmellein (<bold>50</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria</italic> sp. PSU-G12</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia hombroniana</italic> (Branches, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B95-molecules-25-00395" ref-type="bibr">95</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gamahorin (<bold>51</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis heterocornis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phakellia fusca</italic> (Sponge, Axinellidae</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xisha Islands, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B75-molecules-25-00395" ref-type="bibr">75</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin B (<bold>52</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin C (<bold>53</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">S-(−)-6-Hydroxy-8-methoxy-4-(1′-hydroxyethyl)-isocoumarin (<bold>54</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces Amestolkiae</italic> YX1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acetic acid 6,8-dihydroxy-3,5-dimethyl-1-oxo-1H-isochromen-4-ylmethyl ester (<bold>55</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Scytalidium</italic> sp. 5681</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salix</italic> sp. (Leaves, Salicaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Harz Mountains, Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-4-hydroxymethyl-3,5-dimethyl-isochromen-1-one (<bold>56</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Scytalidium</italic> sp. 5681</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salix</italic> sp. (Leaves, Salicaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Harz Mountains, Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Decarboxycitrinone (<bold>57</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Scytalidium</italic> sp. 5681</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salix</italic> sp. (Leaves, Salicaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Harz Mountains, Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4-Acetyl-6,8-dihydroxy-5-methyl-2- benzopyran-1-one (<bold>58</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Scytalidium</italic> sp. 5681</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salix</italic> sp. (Leaves, Salicaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Harz Mountains, Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B27-molecules-25-00395" ref-type="bibr">27</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Diacetoxy-3,5-dimethylisocoumarin (<bold>59</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Mycelia sterile</italic> 4567</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Canadian thistle <italic>Cirsium arvense</italic> (Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicilisorin (<bold>60</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium sclerotiorum</italic> PSUA13</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia atroviridis</italic> (Leaves, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yala Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B124-molecules-25-00395" ref-type="bibr">124</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestalotiorin (<bold>61</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp. PSU-ES194</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Enhalus acoroides</italic> (Leaves, Hydrocharitaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkla Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B41-molecules-25-00395" ref-type="bibr">41</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Tabaisocoumarin A (<bold>62</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> 0456 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B122-molecules-25-00395" ref-type="bibr">122</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus oryzae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. <italic>yunnanensis</italic> (Franch.) Hand.-Mazz. (Rhizomes, Liliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3-Acetoxyl-8-hydroxyl-isocoumarin (<bold>63</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sarcosomataceae</italic> sp. NO.49-14-2-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Everniastrum nepalense</italic> (Taylor) Hale ex Sipman (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Panzhihua, Sichuan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B121-molecules-25-00395" ref-type="bibr">121</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-4-(1-hydroxyethyl)-8-methoxy-1H-isochromen-1-one (<bold>64</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">S-(−)-5,6,8-Trihydroxy-4-(1′-hydroxyethyl)isocoumarin (<bold>65</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. MWZ14-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leave, Rhizophoraceae</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Sescandelin (<bold>66</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. MWZ14-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissue)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Terrecoumarin A (<bold>67</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Terrecoumarin B (<bold>68</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Terrecoumarin C (<bold>69</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestapyrone D (<bold>70</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Photinia frasery</italic> (Leaves, Amygdaloideae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestapyrone E (<bold>71</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Photinia frasery</italic> (Leaves, Amygdaloideae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">LL-Z 1640-7 (<bold>72</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergillspin G (<bold>73</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. SCSIO 41501</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Melitodes squamata</italic> (Gorgonian, Plexauridae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, Sanya Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B70-molecules-25-00395" ref-type="bibr">70</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone E (<bold>74</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone F (<bold>75</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Acremonone G (<bold>76</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone H (<bold>77</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daldiniside B (<bold>78</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Daldinia eschscholzii</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Scaevola sericea Vahl (Branches, Goodeniaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B54-molecules-25-00395" ref-type="bibr">54</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daldiniside C (<bold>79</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Daldinia eschscholzii</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Scaevola sericea Vahl (Branches, Goodeniaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B54-molecules-25-00395" ref-type="bibr">54</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">de-<italic>O</italic>-Methyldiaporthin (<bold>80</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Daldinia eschscholzii</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Scaevola sericea</italic> Vahl (Branches, Goodeniaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B54-molecules-25-00395" ref-type="bibr">54</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Myrothelactone A (<bold>81</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Myrothelactone B (<bold>82</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3-Methyl-8-hydroxyisocoumarin (<bold>83</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sarcosomataceae</italic> sp. NO.49-14-2-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Everniastrum nepalense</italic> (Taylor) Hale ex Sipman (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Panzhihua, Sichuan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B121-molecules-25-00395" ref-type="bibr">121</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-5-methoxy-3-methyl-1H-isochromen-1-one (<bold>84</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leave, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Myrothelactone C (<bold>85</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Myrothelactone D (<bold>86</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Tubakialactone B (<bold>87</bold>)<break></break>8-Hydroxyl-3,4-bis(hydroxymethyl)-6-methoxy-4-methyl-1H-2-benzopyran-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Tubakia</italic> sp. ECN-111 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Houttuynia cordata</italic> Thunb (Leaves, Saururaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chikusa-ku Nagoya city, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B115-molecules-25-00395" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td rowspan="5" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Saccharonol A (<bold>88</bold>)<break></break>6,8-Dihydroxy-3-methylisocoumarin </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus similanensis</italic> sp. nov. KUFA 0013</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhabdermia</italic> sp. (Sponge, Rhabderemiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phang Nga Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B48-molecules-25-00395" ref-type="bibr">48</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria</italic> sp. KcF6</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daya Bay, Shenzhen, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> KJ801852</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. <italic>yunnanensis</italic> (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B126-molecules-25-00395" ref-type="bibr">126</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Similanpyrone B (<bold>89</bold>)<break></break>6,8-Dihydroxy-3,7-dimethylisocoumarin </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus similanensis</italic> sp. nov. KUFA 0013</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhabdermia</italic> sp. (Sponge, Rhabderemiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phang Nga Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B48-molecules-25-00395" ref-type="bibr">48</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp. HQD-6</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora mucronata</italic> (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B126-molecules-25-00395" ref-type="bibr">126</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Reticulol (<bold>90</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus similanensis</italic> sp. nov. KUFA 0013</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhabdermia</italic> sp. (Sponge, Rhabderemiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phang Nga Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B48-molecules-25-00395" ref-type="bibr">48</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Biscogniauxia capnodes</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Averrhoa carambola</italic> L. (Fruits, Oxalidaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"> Kandy, Central Province, Sri Lanka </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B96-molecules-25-00395" ref-type="bibr">96</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-4-hydroxymethyl-8-methoxy-3-methylisocoumarin (<bold>91</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Endophytic fungus (No. GX4-1B)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera gymnoihiza</italic> (L.) Savigny (Branch, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea in Guangxi province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B127-molecules-25-00395" ref-type="bibr">127</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-8-methoxy-3,4-dimethylisocoumarin (<bold>92</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leave, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">3,4-Dimethyl-6,8-dihydroxyisocoumarin (<bold>93</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria pseudotrichia</italic> 120-1NP</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Gliricidia sepium</italic> (Stems, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Wanagama forest of Universitas, Yogyakarta, Indonesia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B128-molecules-25-00395" ref-type="bibr">128</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-4-hydroxymethyl-8-methoxy-3-methyl-isocoumarin (<bold>94</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Sescandelin B (<bold>95</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myrothecium</italic> sp. OUCMDZ-2784</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Apocynum venetum</italic> (Leaves, Apocynaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongying, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-3-hydroxymethyl-8-methoxyisocoumarin (<bold>96</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">4,6-Dihydroxy-3,9-dehydromellein (<bold>97</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergillus <italic>versicolor</italic> KJ801852</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B126-molecules-25-00395" ref-type="bibr">126</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksiamarin A (<bold>98</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksiamarin B (<bold>99</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">6,8-Dihydroxyisocoumarin-3-carboxylic acid (<bold>100</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bionectria</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Raphia taedigera</italic> (Seeds, Arecaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Haut Plateaux region, Cameroon</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B82-molecules-25-00395" ref-type="bibr">82</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria pseudotrichia</italic> 120-1NP</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Gliricidia sepium</italic> (Stem, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Wanagama forest of Universitas, Yogyakarta, Indonesia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B128-molecules-25-00395" ref-type="bibr">128</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. HN15-5D</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Leaves, Acanthaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve, Hainan Island, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nectriapyrone A (<bold>101</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria pseudotrichia</italic> 120-1NP</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Gliricidia sepium</italic> (Stems, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Wanagama forest of Universitas, Yogyakarta, Indonesia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B128-molecules-25-00395" ref-type="bibr">128</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nectriapyrone B (<bold>102</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria pseudotrichia</italic> 120-1NP</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Gliricidia sepium</italic> (Stems, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Wanagama forest of Universitas, Yogyakarta, Indonesia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B128-molecules-25-00395" ref-type="bibr">128</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">6-<italic>O</italic>-Methylreticulol (<bold>103</bold>)<break></break>8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylariaceae</italic> sp. QGS 01</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Quercus gilva</italic> Blume (Stems, Fagaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">EhimeUniversity Garden, Ehime Prefecture, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B102-molecules-25-00395" ref-type="bibr">102</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Biscogniauxia capnodes</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Averrhoa carambola</italic> L. (Fruits, Oxalidaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"> Home garden in Kandy, Central Province, Sri Lanka </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B96-molecules-25-00395" ref-type="bibr">96</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7-Hydroxy-3,5-dimethylisochromen-1-one (<bold>104</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. YE3135</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aconitum vilmorinianum</italic> (Roots, Ranunculaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yunnan University, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B26-molecules-25-00395" ref-type="bibr">26</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-3-hydroxymethylisocoumarin (<bold>105</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> KJ801852</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B126-molecules-25-00395" ref-type="bibr">126</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryospyrone A (<bold>106</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria ramosa</italic> L29 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Leaves, Scrophulariaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryospyrone B (<bold>107</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria ramosa</italic> L29 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Leaves, Scrophulariaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Decarboxyhydroxycitrinone (<bold>108</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Arthrinium sacchari</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">The coast of Atami-shi, ShizuokaPrefecture, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B90-molecules-25-00395" ref-type="bibr">90</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tubakialactone A (<bold>109</bold>) <break></break>8-Hydroxyl-3- hydroxymethyl-6-methoxy-4-methyl-1H-2-benzopyran-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Tubakia</italic> sp. ECN-111 (Melanconidaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Houttuynia cordata</italic> Thunb (Leaves, Saururaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chikusa-ku Nagoya city, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B115-molecules-25-00395" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-7-methyl-1-oxo-1H-isochromene-3-carboxylic acid (<bold>110</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis coffeae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Caryota mitis</italic> (Palm, Arecaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B129-molecules-25-00395" ref-type="bibr">129</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Oryzaein A (<bold>111</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus oryzae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Franch.) Hand-Mazz. (Rhizomes, Liliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Oryzaein B (<bold>112</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus oryzae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Franch.) Hand.-Mazz. (Rhizomes, Liliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Caudacoumarin C (<bold>113</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus oryzae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Franch.) Hand.-Mazz. (Rhizomes, Liliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4,5,7-Trihydroxy-3-methoxy-3,6-dimethylisochroman-1-one (<bold>114</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 16-5B</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sonneratia apetala</italic> (Leaves, Lythraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve in Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B38-molecules-25-00395" ref-type="bibr">38</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5,7-Dihydroxy-3-methoxy-3,6-dimethylisochromane-1,4-dione (<bold>115</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 16-5B</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sonneratia apetala</italic> (Leaves, Lythraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve in Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B38-molecules-25-00395" ref-type="bibr">38</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dihydro-3,6,8-trihydroxy-3,5-dimethylisocoumarin (<bold>116</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Mycelia sterile</italic> 4567</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Canadian thistle <italic>Cirsium arvense</italic> (Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tenuissimasatin (<bold>117</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuissima</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Erythrophleum fordii</italic> (Barks, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanning, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B130-molecules-25-00395" ref-type="bibr">130</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"> Penicoffrazin B (<bold>118</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicoffrazin C (<bold>119</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-3-methoxy-3,7-dimethylisochroman-1-one (<bold>120</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis coffeae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Caryota mitis</italic> (Palm, Arecaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B129-molecules-25-00395" ref-type="bibr">129</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone B (<bold>121</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone C (<bold>122</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone D (<bold>123</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acremonium</italic> sp. PSU-MA70</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora apiculata</italic> (Branches, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Satun Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B125-molecules-25-00395" ref-type="bibr">125</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4-Acetyl-3,4-dihydro-6,8,-dihydroxy-3-methoxy-5-methylisocoumarin (<bold>124</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Mycelia sterile</italic> 4567</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Canadian thistle <italic>Cirsium arvense</italic> (Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4-Acetyl-3,4-dihydro-6,8-dihydroxy-5-methylisocoumarin (<bold>125</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Mycelia sterile</italic> 4567</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Canadian thistle <italic>Cirsium arvense</italic> (Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lower Saxony, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B20-molecules-25-00395" ref-type="bibr">20</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Phomolactone A (<bold>126</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Phomolactone B (<bold>127</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phomolactone C (<bold>128</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-3-hydroxymethyl-8-hydroxyl-3,4-dihydroisocoumarin (<bold>129</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sarcosomataceae</italic> sp. NO.49-14-2-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Everniastrum nepalense</italic> (Taylor) Hale ex Sipman (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Panzhihua, Sichuan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B121-molecules-25-00395" ref-type="bibr">121</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">8-Methylmellein (<bold>130</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sarcosomataceae</italic> sp. NO.49-14-2-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Everniastrum nepalense</italic> (Taylor) Hale ex Sipman (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Panzhihua, Sichuan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B121-molecules-25-00395" ref-type="bibr">121</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp. HHL101</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora stylosa</italic> (Branches, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dong Zhai Gang-Mangrove Garden, Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B72-molecules-25-00395" ref-type="bibr">72</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Trans-4-hydroxymellein (<bold>131</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp.1 and sp.2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alibertia macrophylla</italic> (Leaves, Rubiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mogi-Guaçu, São Paulo, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B18-molecules-25-00395" ref-type="bibr">18</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria</italic> sp. KcF6</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae),</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daya Bay, Shenzhen, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sarcosomataceae</italic> sp. NO.49-14-2-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Everniastrum nepalense</italic> (Taylor) Hale ex Sipman (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Panzhihua, Sichuan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B121-molecules-25-00395" ref-type="bibr">121</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Lachnum palmae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Przewalskia tangutica</italic> Maxim. (Leaves, Solanaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Linzhou Country of the Tibet Autonomous Region, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B51-molecules-25-00395" ref-type="bibr">51</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,5-Dimethyl-8-hydroxy-7-methoxy-3,4-dihydroisocoumarin (<bold>132</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cytospora eucalypticola</italic> SS8</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eucalyptus perriniana</italic> (Bark, Myrtaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Royal Botanic Gardens, Kew, United Kingdom</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin (<bold>133</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cytospora eucalypticola</italic> SS8</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eucalyptus perriniana</italic> (Barks, Myrtaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Royal Botanic Gardens, Kew, United Kingdom</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td rowspan="5" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R)-5-Methylmellein (<bold>134</bold>)<break></break>3,4-Dihydro-(3R),5-dimethyl-8-hydroxyisocoumarin </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cytospora eucalypticola</italic> SS8</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eucalyptus perriniana</italic> (Barks, Myrtaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Royal Botanic Gardens, Kew, United Kingdom</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Centraalbureau voor</italic> Schimmel cultures (120379) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Picea glauca</italic> (Leaves, Pinaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sussex, New Brunswick, Canada</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-molecules-25-00395" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria</italic> sp. PSU-G12</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia hombroniana</italic> (Branchs, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B95-molecules-25-00395" ref-type="bibr">95</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Xylaria cubensis</italic> (Xylariaceae) BCRC 09F 0035</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Litsea akoensis</italic> Hayata (Leaves, Lauraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kaohsiung, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B109-molecules-25-00395" ref-type="bibr">109</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Biscogniauxia capnodes</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Averrhoa carambola</italic> L. (Fruits, Oxalidaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Home garden in Kandy, Central Province, Sri Lanka </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B96-molecules-25-00395" ref-type="bibr">96</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5-Hydroxymethylmellein (<bold>135</bold>)<break></break>8-Hydroxy-5-hydroxymethyl-3-methyl-3,4-dihydroisocoumarin</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cytospora eucalypticola</italic> SS8</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eucalyptus perriniana</italic> (Barks, Myrtaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Royal Botanic Gardens, Kew, United Kingdom</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4,8-Dihydroxy-3,5-dimethyl-3,4-dihydroisocoumarin (<bold>136</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cytospora eucalypticola</italic> SS8</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eucalyptus perriniana</italic> (Barks, Myrtaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Royal Botanic Gardens, Kew, United Kingdom</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Periplanetin D (<bold>137</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, People’sRepublic of China,</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium oxalicum</italic> 0403</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nicotiana sanderae</italic> (Leaves, Solanaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shilin, Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis coffeae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Caryota mitis</italic> (Palm, Arecaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B129-molecules-25-00395" ref-type="bibr">129</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestalactone C (<bold>138</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Photinia frasery</italic> (Leaves, Amygdaloideae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(4S) (+)-Ascochin (<bold>139</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascochyta</italic> sp. </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Meliotus dentatus</italic> (Whole plant, Fabaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shores of the Baltic Sea, near Ahrenshoop, Germany</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B117-molecules-25-00395" ref-type="bibr">117</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(4S)-Thielavic acid (<bold>140</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Thielavia</italic> sp. ECN-115</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Crassula ovata</italic> (Stems, Crassulaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chikusa-ku Nagoya city, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B115-molecules-25-00395" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phomasatin (<bold>141</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. YN02-P-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sumbaviopsis albicans</italic> J. J. Smith (Leaves, Euphorbiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B84-molecules-25-00395" ref-type="bibr">84</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dihydro-6-methoxy-8-hydroxy-3,4,5-trimethyl-isocoumarin-7-carboxylic acid methyl ester (<bold>142</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fungus dz17 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mangrove plant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea coast, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B88-molecules-25-00395" ref-type="bibr">88</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dihydro-4,8-dihydroxy-3,5-dimethylisocoumarin (<bold>143</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fungus dz17 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mangrove plant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea coast, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B88-molecules-25-00395" ref-type="bibr">88</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dihydro-8-hydroxy-3-methylisocoumarin-5-carboxylic acid (<bold>144</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fungus dz17 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mangrove plant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea coast, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B88-molecules-25-00395" ref-type="bibr">88</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"> Pestalotiopisorin B (<bold>145</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp. HHL101</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhizophora stylosa</italic> (Branches, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dong Zhai Gang-Mangrove Garden, Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B72-molecules-25-00395" ref-type="bibr">72</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestaloisocoumarin A (<bold>146</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis heterocornis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phakellia fusca</italic> (Sponge, Axinellidae</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xisha Islands, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B75-molecules-25-00395" ref-type="bibr">75</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestaloisocoumarin B (<bold>147</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis heterocornis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phakellia fusca</italic> (Sponge, Axinellidae</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xisha Islands, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B75-molecules-25-00395" ref-type="bibr">75</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tubakialactone C (<bold>148</bold>)<break></break>(R)-3,4-Dihydro-4,8-dihydroxy-6-methoxy-4-methyl-3-methylene-1H-2-benzopyran-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Tubakia</italic> sp. ECN-111 (Melanconidaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Houttuynia cordata</italic> Thunb (Leaves, Saururaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chikusa-ku Nagoya city, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B115-molecules-25-00395" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(R)-3,4-dihydro-4-hydroxyl-6,8-dimethoxy-4-methyl-3-methylene-1H-2-benzopyran-1-one (<bold>149</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Tubakia</italic> sp. ECN-111 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Houttuynia cordata</italic> Thunb (Leaves, Saururaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chikusa-ku Nagoya city, Japan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B115-molecules-25-00395" ref-type="bibr">115</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(6,8-dihydroxy-3-methyl-1-oxo-1H-isochromen-4-yl)methyl-3-methylbutanoate (<bold>150</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin D (<bold>151</bold>)</td><td align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. MWZ14-4</td><td align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin E (<bold>152</bold>)
</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. MWZ14-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Penicimarin F (<bold>153</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. MWZ14-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> KJ801852</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B126-molecules-25-00395" ref-type="bibr">126</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin G (<bold>154</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium citrinum</italic> HL-5126</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, P.R. China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B56-molecules-25-00395" ref-type="bibr">56</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin H (<bold>155</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium citrinum</italic> HL-5126</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B56-molecules-25-00395" ref-type="bibr">56</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin I (<bold>156</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium citrinum</italic> HL-5126</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B56-molecules-25-00395" ref-type="bibr">56</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicisimpin A (<bold>157</bold>)<break></break>3-(R)-6,8-Dihydroxy-7-methyl-3-pentylisochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium simplicissimum</italic> MA-332</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicisimpin B (<bold>158</bold>)<break></break>3-(R)-6,8-Dihydroxy-3-pentylisochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium simplicissimum</italic> MA-332</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicisimpin C (<bold>159</bold>)<break></break>3-(S)-6,8-Dihydroxy-7-methyl-3-(pent-1-enyl)isochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium simplicissimum</italic> MA-332</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fusarentin 6-methyl ether (<bold>160</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum</italic> sp. CRI535-02</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Piper ornatum</italic> (Leaves, Piperaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tai Rom Yen National Park, Surat Thani Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fusarentin 6,7-dimethyl ether (<bold>161</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum</italic> sp. CRI535-02</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Piper ornatum</italic> (Leaves, Piperaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tai Rom Yen National Park, Surat Thani Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7-Butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (<bold>162</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Geotrichum</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Crassocephalum crepidioides</italic> S. Moore (Stems, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla Province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7-But-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (<bold>163</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Geotrichum</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Crassocephalum crepidioides</italic> S. Moore (Stems, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla Province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7-Butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (<bold>164</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Geotrichum</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Crassocephalum crepidioides</italic> S. Moore (Stems, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Songkhla Province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B74-molecules-25-00395" ref-type="bibr">74</xref>]</td></tr><tr><td rowspan="6" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Monocerin (<bold>165</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Microdochium bolleyi</italic> 8880</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Fagonia cretica</italic> (Leaves, Zygophyllaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum rostratum</italic> EU571210</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Stemona</italic> sp. (Leaves and roots, Stemonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphur Bangban, Ayutthaya Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum</italic> sp. CRI535-02</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Piper ornatum</italic> (Leaves, Piperaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tai Rom Yen National Park, Surat Thani Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria</italic> sp. KcF6</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daya Bay, Shenzhen, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum rostratum</italic> ER1.1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bauhinia guianensis</italic> (Fabaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Embrapa Amazônia Oriental Belém, Brazil</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Leptosphaena maculans</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Osmanthus fragrans</italic> (Leaves, Oleaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B104-molecules-25-00395" ref-type="bibr">104</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">7-<italic>O</italic>-Demethylmonocerin (<bold>166</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum</italic> sp. CRI535-02</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Piper ornatum</italic> (Leaves, Piperaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tai Rom Yen National Park, Surat Thani Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xuwen, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(12R)-Hydroxymonocerin (<bold>167</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Microdochium bolleyi</italic> 8880</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Fagonia cretica</italic> (Leaves, Zygophyllaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Leptosphaena maculans</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Osmanthus fragrans</italic> (Leaves, Oleaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B104-molecules-25-00395" ref-type="bibr">104</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(11R)-Hydroxymonocerin (<bold>168</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum rostratum</italic> EU571210</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Stemona</italic> sp. (Leaves and roots, Stemonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphur Bangban, Ayutthaya Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(12S)-Hydroxymonocerin (<bold>169</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Microdochium<break></break>bolleyi 8880</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Fagonia cretica</italic> (Leaves, Zygophyllaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Exserolide D (<bold>170</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus oryzae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Franch.) Hand.-Mazz. (Rhizomes, Liliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Exserolide E (<bold>171</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Exserolide I (<bold>172</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Exserolide J (<bold>173</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Maculansline D (<bold>174</bold>)<break></break>Isomer of (12R)-12-hydroxymonocerin</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Leptosphaena maculans</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Osmanthus fragrans</italic> (Leaves, Oleaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B104-molecules-25-00395" ref-type="bibr">104</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Exserolide A (<bold>175</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Exserolide B (<bold>176</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Exserolide C (<bold>177</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Exserolide K (<bold>178</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Setosphaeria</italic> sp. SCSIO41009</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Callyspongia</italic> sp. (Sponge, Callyspongiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestalactone A (<bold>179</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Photinia frasery</italic> (Leaves, Amygdaloideae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestalactone B (<bold>180</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pestalotiopsis</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Photinia frasery</italic> (Leaves, Amygdaloideae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">8-Dihydroramulosin (<bold>181</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. PSU-N24</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia nigrolineata</italic> (Branches, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ton Nga Chang wildlife sanctuary, Songkhla province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B110-molecules-25-00395" ref-type="bibr">110</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. LLGLM003</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Moringa oleifera</italic> (Roots, Moringaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Xiamen municipality, Fujian Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B53-molecules-25-00395" ref-type="bibr">53</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6β-Hydroxy-8-dihydroramulosin (<bold>182</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. PSU-N24</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia nigrolineata</italic> (Branches, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ton Nga Chang wildlife sanctuary, Songkhla province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B110-molecules-25-00395" ref-type="bibr">110</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(−) Ramulosin (<bold>183</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces</italic> sp. JQ769262</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cedrus deodara</italic> (Twigs, Pinaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lolab Valley in the Western Himalayas, Kashmir, India</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B83-molecules-25-00395" ref-type="bibr">83</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3S,4aR,7S)-7,8-Dihydroxy-3-methyl-3,4,10,5,6,7-hexahydro-1H-isochromen-1-one (<bold>184</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces</italic> sp. JQ769262</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cedrus deodara</italic> (Twigs, Pinaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Lolab Valley in the Western Himalayas, Kashmir, India</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B83-molecules-25-00395" ref-type="bibr">83</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxyramulosin (<bold>185</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nigrospora</italic> sp. PSU-N24</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Garcinia nigrolineata</italic> (Branches, Clusiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ton Nga Chang wildlife sanctuary, Songkhla province, Southern Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B110-molecules-25-00395" ref-type="bibr">110</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin A (<bold>186</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin B (<bold>187</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Alternariol (<bold>188</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria</italic> sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Polygonum senegalense</italic> Meisn. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuissima</italic> SP-07</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salvia przewalskii</italic> (Roots, Lamiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Longxi County, Gansu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B57-molecules-25-00395" ref-type="bibr">57</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Alternariol-5-<italic>O</italic>-methyl ether (<bold>189</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alternaria sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Polygonum <italic>senegalense Meisn</italic>. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuissima</italic> SP-07</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salvia przewalskii</italic> (Roots, Lamiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Longxi County, Gansu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B57-molecules-25-00395" ref-type="bibr">57</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3′-Hydroxyalternariol 5-<italic>O</italic>-methyl ether (<bold>190</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria</italic> sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Polygonum senegalense</italic> Meisn. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alternariol 5-<italic>O</italic>-sulfate (<bold>191</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria</italic> sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Polygonum senegalense</italic> Meisn. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alternariol 5-<italic>O</italic>-methyl ether-4′-<italic>O</italic>-sulfate (<bold>192</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria</italic> sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Polygonum senegalense</italic> Meisn. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Altenuene (<bold>193</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria</italic> sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Polygonum senegalense</italic> Meisn. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuissima</italic> SP-07</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salvia przewalskii</italic> (Roots, Lamiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Longxi County, Gansu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B57-molecules-25-00395" ref-type="bibr">57</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(−)-(2R,3R,4aR)-Altenuene-2-acetoxy ester (+)-(2S,3S,4aS)-Altenuene-2-acetoxy ester (<bold>194</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(−)-(2R,3R,4aR)-Altenuene-3-acetoxy ester (+)-(2S,3S,4aS)-Altenuene-3-acetoxy ester (<bold>195</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">5′-Epialtenuene (<bold>196</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria</italic> sp. II2L4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Polygonum senegalense</italic> Meisn. (Leaves, Polygonaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cycloepoxylactone (<bold>197</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">EI-1941-2 (<bold>198</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cycloepoxytriol A (<bold>199</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cycloepoxytriol B (<bold>200</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Exserolide F (<bold>201</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Exserohilum</italic> sp. KJ156361 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acer truncatum</italic> (Leaves, Sapindaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongling Mountain, Beijing, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus oryzae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Franch.) Hand.-Mazz. (Rhizomes, Liliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B94-molecules-25-00395" ref-type="bibr">94</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Isocitreoisocoumarinol (<bold>202</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="5" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(+)-Citreoisocoumarin (<bold>203</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ampelomyces</italic> sp. EU143251.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Urospermum picroides</italic> (Flowers, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B39-molecules-25-00395" ref-type="bibr">39</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria</italic> sp. HN001</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sonneratia ovata</italic> (Branches, Lythraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea in Hainan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. TA07-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Dichotella gemmacea</italic> GX-WZ-2008003-4 (Gorgonian, Plexauridae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou coral reef, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B131-molecules-25-00395" ref-type="bibr">131</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(+)-6-Methylcitreoisocoumarin (<bold>204</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. sponge (Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Citreoisocoumarinol (<bold>205</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria</italic> sp. HN001</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sonneratia ovata</italic> (Branches, Lythraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, Hainan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. (TA07-1)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Dichotella gemmacea</italic> GX-WZ-2008003-4 (Gorgonian, Plexauridae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou coral reef, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B131-molecules-25-00395" ref-type="bibr">131</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12-epicitreoisocoumarinol (<bold>206</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Nectria</italic> sp. HN001</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Sonneratia ovata</italic> (Branches, Lythraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, Hainan province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B33-molecules-25-00395" ref-type="bibr">33</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mucorisocoumarin A (<bold>207</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Mucorisocoumarin B (<bold>208</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin A (<bold>209</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin B (<bold>210</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin C (<bold>211</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="5" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Aspergillumarin A (<bold>212</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera gymnorrhiza</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea coast, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B61-molecules-25-00395" ref-type="bibr">61</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. (MWZ14-4)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium citrinum</italic> HL-5126</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Roots, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B56-molecules-25-00395" ref-type="bibr">56</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Aspergillumarin B (<bold>213</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera gymnorrhiza</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea coast, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B61-molecules-25-00395" ref-type="bibr">61</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. (MWZ14-4)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Penicimarin B (<bold>214</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. (MWZ14-4)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Penicimarin C (<bold>215</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. (MWZ14-4)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(R)-3-((R)-4,5-Dihydroxypentyl)-8-hydroxyisochroman-1-one (<bold>216</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5,6-Dihydroxy-3-(4-hydroxypentyl)isochroman-1-one (<bold>217</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Talaromyces amestolkiae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia obovata</italic> (Leaves, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhanjiang, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Maculansline C (<bold>218</bold>)<break></break>3S, 10S-Dihydroisocoumarin, (Epimer)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Leptosphaena maculans</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Osmanthus fragrans</italic> (Leaves, Oleaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B104-molecules-25-00395" ref-type="bibr">104</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Desmethyldiaportinol (<bold>219</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ampelomyces</italic> sp. EU143251.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Urospermum picroides</italic> (Flowers, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B39-molecules-25-00395" ref-type="bibr">39</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. (TA07-1)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Dichotella gemmacea</italic> GX-WZ-2008003-4 (Gorgonian, Plexauridae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou coral reef, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B131-molecules-25-00395" ref-type="bibr">131</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Dichlorodiaportin (<bold>220</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Trichoderma</italic> sp. 09</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Roots, Scrophulariaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Trichoderma</italic> sp. 09</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Roots, Scrophulariaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. HN15-5D</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Leaves, Acanthaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve, Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Desmethyldichlorodiaportin (<bold>221</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ampelomyces</italic> sp. EU143251.</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Urospermum picroides</italic> (Flowers, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alexandria, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B39-molecules-25-00395" ref-type="bibr">39</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin D (<bold>222</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruit, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin E (<bold>223</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin F (<bold>224</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Peniisocoumarin G (<bold>225</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin H (<bold>226</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin I (<bold>227</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin J (<bold>228</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3-[(R)-3,3-Dichloro-2-hydroxypropyl]-8-hydroxy-6-methoxy-1H-isochromen-1-one (<bold>229</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(+)-Diaporthin (<bold>230</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Diaportinol (<bold>231</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Trichoderma</italic> sp. 09</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Roots, Scrophulariaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phoma</italic> sp. (TA07-1)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Dichotella gemmacea</italic> GX-WZ-2008003-4 (Gorgonian, Plexauridae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou coral reef, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B131-molecules-25-00395" ref-type="bibr">131</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(+)-(10R)-7-Hydroxy-3-(2-hydroxy-propyl)-5,6-dimethylisochromen-1-one (<bold>232</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin D (<bold>233</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Orthosporin (<bold>234</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8-Methyl-11-chlorodiaporthin (<bold>235</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. CPCC 400810</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cetrelia</italic> sp. (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Laojun Mount in Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8-Methyl-11,11-dichlorodiaporthin (<bold>236</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. CPCC 400810</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cetrelia</italic> sp. (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Laojun Mount in Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8-Hydroxy-6-methoxy-3-(2,3,3-trihydroxypropyl)-1H-isochromen-1-one (<bold>237</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium funiculosum</italic> Fes1711</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ficus elastica</italic> (Leaves, Moraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Liaocheng University Arboretum, Liaocheng, Shandong, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B69-molecules-25-00395" ref-type="bibr">69</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8-Hydroxy-6-methoxy-3-(1,2,3-trihydroxypropyl)-1H-isochromen-1-one (<bold>238</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium funiculosum</italic> Fes1711</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ficus elastica</italic> (Leaves, Moraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Liaocheng University Arboretum, Liaocheng, Shandong, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B69-molecules-25-00395" ref-type="bibr">69</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin C (<bold>239</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. HN15-5D</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Leaves, Acanthaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve, Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4R,10R)-Fusarentin 4-hydroxy-6,7-dimethyl ether (<bold>240</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Microdochium bolleyi</italic> 8880</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Fagonia cretica</italic> (Leaves, Zygophyllaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum</italic> sp. CRI535-02</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Piper ornatum</italic> (Leaves, Piperaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tai Rom Yen National Park, Surat Thani Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colletomellein A (<bold>241</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum aotearoa</italic> BCRC 09F0161 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bredia oldhamii</italic> Hook. f. (Leaves, Melastomataceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mutan, Pingtung County, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B132-molecules-25-00395" ref-type="bibr">132</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colletomellein B (<bold>242</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Colletotrichum aotearoa</italic> BCRC 09F0161 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bredia oldhamii</italic> Hook. f. (Leaves, Melastomataceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mutan, Pingtung County, Taiwan</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B132-molecules-25-00395" ref-type="bibr">132</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin D (<bold>243</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin F (<bold>244</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin H (<bold>245</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dihydro-8-hydroxy-6-methoxy-(3R)-propylisocoumarin (<bold>246</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Centraalbureau voor</italic> Schimmel cultures (120379) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Picea glauca</italic> (Leaves, Pinaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sussex, New Brunswick, Canada</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B119-molecules-25-00395" ref-type="bibr">119</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin C (<bold>247</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin E (<bold>248</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniciisocoumarin G (<bold>249</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(R)-3-(3-Hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin (<bold>250</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. TGM112</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera sexangula</italic> var. rhynchopetala (Leaves, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B67-molecules-25-00395" ref-type="bibr">67</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin A (<bold>251</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Stearn (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin D (<bold>252</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris marmorata</italic> Steam (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B89-molecules-25-00395" ref-type="bibr">89</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Paraphaeosphaerin A (<bold>253</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paraphaeosphaeria quadriseptata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Opuntia leptocaulis</italic> (Rhizosphere, Cactaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tucson, Arizon</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B133-molecules-25-00395" ref-type="bibr">133</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Paraphaeosphaerin B (<bold>254</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paraphaeosphaeria quadriseptata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Opuntia leptocaulis</italic> (Rhizosphere, Cactaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tucson, Arizon, America</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B133-molecules-25-00395" ref-type="bibr">133</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chaetochiversin A (<bold>255</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Chaetomium chiversii</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ephedra fasciculata</italic> (Stems, Ephedraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South mountain park, Phoenix, Arizona, America</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B133-molecules-25-00395" ref-type="bibr">133</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chaetochiversin B (<bold>256</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Chaetomium chiversii</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ephedra fasciculata</italic> (Stems, Ephedraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South mountain park, Phoenix, Arizona, America</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B133-molecules-25-00395" ref-type="bibr">133</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Paraphaeosphaerin C (<bold>257</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paraphaeosphaeria quadriseptata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Opuntia leptocaulis</italic> (Rhizosphere, Cactaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tucson, Arizon, America</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B133-molecules-25-00395" ref-type="bibr">133</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin C (<bold>258</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,6′-Dinor-bipenicilisorin (<bold>259</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> KU258497</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eichhornia crassipes</italic> (Leaves, Pontederiaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mansoura, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B81-molecules-25-00395" ref-type="bibr">81</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,6′,9′-Trinor-bipenicilisorin (<bold>260</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> KU258497</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Eichhornia crassipes</italic> (Leaves, Pontederiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mansoura, Egypt</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B81-molecules-25-00395" ref-type="bibr">81</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin A (<bold>261</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 085242</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Roots, Acanthaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove National Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin B (<bold>262</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 085242</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Roots, Acanthaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove National Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin C (<bold>263</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 085242</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Roots, Acanthaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove National Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin D (<bold>264</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 085242</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Roots, Acanthaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove National Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin E (<bold>265</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 085242</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Roots, Acanthaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove National Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin F (<bold>266</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. 085242</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Roots, Acanthaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove National Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin A (<bold>267</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruit, Rhizophoraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin B (<bold>268</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium commune</italic> QQF-3</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sg17-1-4 (<bold>269</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuis</italic> Sg17-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhoushan Island, Zhejiang Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B85-molecules-25-00395" ref-type="bibr">85</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AI-77-B (<bold>270</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuis</italic> Sg17-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhoushan Island, Zhejiang Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B85-molecules-25-00395" ref-type="bibr">85</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AI-77-F (<bold>271</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria tenuis</italic> Sg17-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Marine alga</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Zhoushan Island, Zhejiang Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B85-molecules-25-00395" ref-type="bibr">85</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Similanpyrone A (<bold>272</bold>)<break></break>5-Hydroxy-8-methyl-2H,6H-pyrano [3,4-g]chromen-2,6-dione </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus similanensis</italic> sp. nov. KUFA 0013</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhabdermia</italic> sp. (Sponge, Rhabderemiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phang Nga Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B48-molecules-25-00395" ref-type="bibr">48</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Similanpyrone C (<bold>273</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus similanensis</italic> KUFA 0013</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Rhabdermia</italic> sp. (Sponge, Rhabderemiidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phang Nga Province, Thailand</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B28-molecules-25-00395" ref-type="bibr">28</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin A (<bold>274</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. HN15-5D</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Leaves, Acanthaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve, Hainan Island, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin B (<bold>275</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. HN15-5D</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Acanthus ilicifolius</italic> (Leaves, Acanthaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dongzhaigang Mangrove National Nature Reserve, Hainan Island, China.</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dothideomynone A (<bold>276</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone A (<bold>277</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone F (<bold>278</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone E (<bold>279</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone B (<bold>280</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone C (<bold>281</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone D (<bold>282</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone G (<bold>283</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone H (<bold>284</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Banksialactone I (<bold>285</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Demethylcitreoviranol (<bold>286</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Citreoviranol (<bold>287</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Peyronellaea glomerata</italic> XSB-01-15 </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Amphimedon</italic> sp. (Sponge, Niphatidae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Yongxin Island, Hainan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Desmethyldichlorodiaportinol (<bold>288</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dichlorodiaportinol A (<bold>289</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Trichoderma</italic> sp., 09</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Roots, Scrophulariaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B79-molecules-25-00395" ref-type="bibr">79</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dichlorodiaportinolide (<bold>290</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Trichoderma</italic> sp. 09</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Myoporum bontioides</italic> (Roots, Scrophulariaceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Leizhou Peninsula, Guangdong Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dichlorodiaportintone (<bold>291</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Desmethyldichlorodiaportintone (<bold>292</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ascomycota</italic> sp. CYSK-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pluchea indica</italic> (Branches, Asteraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Shankou Mangrove Nature Reserve, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryoisocoumarin A (<bold>293</bold>)<break></break>3S-5,8-dihydroxy-3-hydroxymethyldihydroisocoumarin</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Botryosphaeria</italic> sp. KcF6</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Kandelia candel</italic> (Fruits, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Daya Bay, Shenzhen, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Clearanol I (<bold>294</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus banksianus</italic> sp. nov</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Banksia integrifolia</italic> (Leaves, Proteaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Collaroy, New South Wales, Australia</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B30-molecules-25-00395" ref-type="bibr">30</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin A (<bold>295</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. MWZ14-4</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Unidentified sponge GX-WZ-2008001 (Inner fresh tissues)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Weizhou, South China Sea, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Isocoumarindole A (<bold>296</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus</italic> sp. CPCC400810</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Cetrelia</italic> sp. (Lichen, Parmeliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Laojun Mount in Yunnan Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Prochaetoviridin A (<bold>297</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Chaetomium globosum</italic> CDW7 (Chaetomiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Ginkgo biloba</italic> (Ginkgoaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Jiangsu province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B77-molecules-25-00395" ref-type="bibr">77</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Fusariumin (<bold>298</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Fusarium</italic> sp. LN-10</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Melia azedarach</italic> (Leaves, Meliaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Campus of Northwest A&F University, Yangling, Shaanxi province, China,</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B86-molecules-25-00395" ref-type="bibr">86</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Aspergillus versicolor</italic> KJ801852</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Paris polyphylla</italic> var. yunnanensis (Rhizomes, Melanthiaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dali, Yunnan, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B126-molecules-25-00395" ref-type="bibr">126</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Phialophoriol (<bold>299</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Alternaria alternata</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Camellia sinensis</italic> (Branches, Theaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nanjing, Jiangsu Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3aR,9bR)-6,9b-Dihydroxy-8-methoxy-1-methylcyclopentene[c]isochromen-3,5-dione (<bold>300</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium</italic> sp. </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Riccardia multifida</italic> (L.) S. Gray (Liverwort, Aneuraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Maoer Mountain, Guangxi Province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B116-molecules-25-00395" ref-type="bibr">116</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3S,4S)-Dihydroascochin (<bold>301</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Phomopsis</italic> sp. 7233</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laurus azorica</italic> (Leaves, Lauraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gomera, Spain</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3-Methoxy-6,8-dihydroxy-3-methyl-3,4-dihydroisocoumarin (<bold>302</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Cis-4,6-Dihydroxymellein (<bold>303</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dihydro-8-hydroxyisocoumarin-3-carboxylic methyl ether (<bold>304</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Seltsamia galinsogisoli</italic> sp. nov. SYPF 7336</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Galinsoga parviflora</italic> (Whole plant, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Huludao, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B78-molecules-25-00395" ref-type="bibr">78</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3-Hydroxymethyl-6,8-dimethoxycoumarin (<bold>305</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Endophytic fungus No. GX4-1B</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Bruguiera gymnoihiza</italic> (L.) Savigny (Branches, Rhizophoraceae) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">South China Sea, Guangxi province, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B127-molecules-25-00395" ref-type="bibr">127</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1H-2-Benzopyran-1-one,6,8-dihydroxy-3-(2-hydroxypropyl) (<bold>306</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Seltsamia galinsogisoli</italic> sp. nov. SYPF 7336</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Galinsoga parviflora</italic> (Whole plant, Asteraceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Huludao, China</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B78-molecules-25-00395" ref-type="bibr">78</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-3-hydroxymethyl-1H-2-benzopyran-1-one (<bold>307</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Penicillium coffeae</italic> MA-314</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Laguncularia racemose</italic> (Leaves, Combretaceae)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Hainan island, China </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B47-molecules-25-00395" ref-type="bibr">47</xref>]</td></tr></tbody></table></table-wrap><table-wrap id="molecules-25-00395-t002" orientation="portrait" position="float"><object-id pub-id-type="pii">molecules-25-00395-t002_Table 2</object-id><label>Table 2</label><caption><p>Biological activities of the most active fungal isocoumarins.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Compound Name</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Biological Activity</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Assay, Organism, or Cell Line</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Biological Results</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Positive Control</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">References</th></tr></thead><tbody><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Kigelin (<bold>1</bold>)<break></break>(−)-(3R)-6,7-Dimethoxymellein </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Trichophyton longifusus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">45 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 70 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>A. flavus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ampicillin 20 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Microsporum canis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 98.4 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4R)-6,7-Dimethoxy-4-hydroxymellein (<bold>2</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Trichophyton longifusus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">70 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 70 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Microsporum canis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 98.4 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Fusarium solani</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 73.2 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">XO Inhibition </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">707 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">PG 628 μM (IC<sub>50</sub>)<break></break>BHA 591 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td rowspan="5" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Cis-4-Acetoxyoxymellein (<bold>4</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 14 mm (GI)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Bacillus megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 18 mm (GI)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Septoria tritici</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Algicidal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Chlorella fusca</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Actidione 35 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td rowspan="6" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">8-Deoxy-6-hydroxy-cis-4-acetoxyoxymellein (<bold>5</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>E</italic>. <italic>coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 14 mm (GI)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Bacillus megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 18 mm (GI)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Botrytis cinerea</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 0 mm (IZD)<break></break>Actidione 0 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Septoria tritici</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Algicidal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Chlorella fusca</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Actidione 35 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B50-molecules-25-00395" ref-type="bibr">50</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4R)-(−)-4-Hydroxymellein<break></break>(3R,4R)-Cis-4-Hydroxymellein (<bold>6</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Bacillus megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 14 mm (GI)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B43-molecules-25-00395" ref-type="bibr">43</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B43-molecules-25-00395" ref-type="bibr">43</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Algicidal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Chlorella fusca</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Actidione 35 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B43-molecules-25-00395" ref-type="bibr">43</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(−)-6-Methoxymellein (<bold>11</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antiviral </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CPE inhibition/H1N1 virus</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20.98 µg/mL (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Arbidol 0.15 µg/mL (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B26-molecules-25-00395" ref-type="bibr">26</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Botryospyrone C (<bold>13</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2-Fold broth dilution method/<italic>F. oxysporum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">223 μM (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Triadimefon 340 μM (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2-Fold broth dilution method/<italic>F. graminearum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">223 μM (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Triadimefon 510.7 μM (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td rowspan="5" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">6-(4′-Hydroxy-2′-methyl phenoxy)-(−)-(3R)-mellein (<bold>16</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Trichophyton longifusus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">55 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 70 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Microsporum canis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">70 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 98.4 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar tube dilution/<italic>Fusarium solani</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">30 (% Inhibition)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Miconazole 73.2 (% Inhibition)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DPPH </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">159 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">PG 30 159 μM (IC<sub>50</sub>)<break></break>BHA 44 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">XO Inhibition </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">243 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">PG 628 μM (IC<sub>50</sub>)<break></break>BHA 591 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B68-molecules-25-00395" ref-type="bibr">68</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4R)-3,4-Dihydro-4,6-dihydroxy-3-methyl-1-oxo-1H-isochromene-5-carboxylic acid (<bold>34</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Direct Bioautography Overaly/<italic>Cladosporium cladosporioides</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 1µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Direct Bioautography Overlay/<italic>Cladosporium sphaerospermum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 1 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acetylcholinesterase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TLC-based AChE inhibition </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3 µg (IC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Galantamine 1µg (IC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-Mellein (<bold>35</bold>)<break></break>3,4-Dihydro-(3R)-methyl-8-hydroxyisocoumarin</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Botrytis cinerea</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">49.2 µg/mL (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B53-molecules-25-00395" ref-type="bibr">53</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(R)-7-Hydroxymellein (<bold>36</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Direct Bioautography Overlay/<italic>Cladosporium cladosporioides</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 1µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Direct Bioautography Overlay/<italic>Cladosporium sphaerospermum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 1µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acetylcholinesterase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TLC-based AChE inhibition </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µg (IC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Galantamine 1µg (IC) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(3R,4R)-4,7-Dihydroxymellein (<bold>37</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Direct Bioautography Overlay/<italic>Cladosporium cladosporioides</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 1 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Direct Bioautography Overlay/<italic>Cladosporium sphaerospermum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 1 µg (Minimum amount required for inhibition of fungi growth on TLC plates)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acetylcholinesterase inhibitory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TLC-based AChE inhibition </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µg (IC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Galantamine 1µg (IC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B17-molecules-25-00395" ref-type="bibr">17</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Periplanetin A (<bold>39</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">14.6% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-Methyl-8-hydroxy-6-(hydroxymethyl)-7-methoxydihydroisocoumarin (<bold>40</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antiviral </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">21.8% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 32.8% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(3R)-Methyl-7,8-dimethoxy-6-(hydroxymethyl)<break></break>dihydroisocoumarin (<bold>41</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antiviral</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">18.6% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 32.8% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B112-molecules-25-00395" ref-type="bibr">112</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">S-(-)-5-Hydroxy-8-methoxy-4-(1′-hydroxyethyl)-isocoumarin (<bold>54</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">537.3 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">S-(-)-5,6,8-Trihydroxy-4-(1′-hydroxyethyl)isocoumarin (<bold>65</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">315.3 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>S. aureus</italic> (ATCC 27154)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12.5 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.160 μM (MIC<sub>50</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>B. cereus</italic> (ACCC 11077)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6.25 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.625 μM (MIC<sub>50</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Vibrio parahemolyticus</italic> (ATCC17802)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6.25 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.160 μM (MIC<sub>50</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sescandelin (<bold>66</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">417.8 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Terrecoumarin A (<bold>67</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25.4% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Terrecoumarin B (<bold>68</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">14.5% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Terrecoumarin C (<bold>69</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16.3% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">LL-Z 1640-7 (<bold>72</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.87 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acremonone G (<bold>76</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.37 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 0.47 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Myrothelactone A (<bold>81</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.32 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 0.47 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,8-Dihydroxy-5-methoxy-3-methyl-1H-isochromen-1-one (<bold>84</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">89.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Myrothelactone C (<bold>85</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.036 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 0.47 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Tubakialactone B (<bold>87</bold>)<break></break>8-Hydroxyl-3,4-bis(hydroxymethyl)-6-methoxy-4-methyl-1H-2-benzopyran-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.026 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 0.47 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B103-molecules-25-00395" ref-type="bibr">103</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-8-methoxy-3,4-dimethylisocoumarin (<bold>92</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">585.7 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3,4-Dimethyl-6,8-dihydroxyisocoumarin (<bold>93</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">36.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-4-hydroxymethyl-8-methoxy-3-methyl-isocoumarin (<bold>94</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">302.6 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Sescandelin B (<bold>95</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17.2 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6-Hydroxy-3-hydroxymethyl-8-methoxyisocoumarin (<bold>96</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">18.7% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4,6-Dihydroxy-3,9-dehydromellein (<bold>97</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13.8% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryospyrone A (<bold>106</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2-Fold broth dilution method/<italic>F. oxysporum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">112.6 μM (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Triadimefon 340 μM (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Botryospyrone B (<bold>107</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2-Fold broth dilution method/<italic>F. oxysporum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">105.8 μM (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Triadimefon 340 μM (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2-Fold broth dilution method/<italic>F. graminearum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">211.7 μM (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Triadimefon 510.7 μM (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B71-molecules-25-00395" ref-type="bibr">71</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4,5,7-Trihydroxy-3-methoxy-3,6-dimethylisochroman-1-one (<bold>114</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">IC<sub>50</sub> 90.4 μM</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose (IC<sub>50</sub> 553.7 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B38-molecules-25-00395" ref-type="bibr">38</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">3,5-Dimethyl-8-hydroxy-7-methoxy-3,4-dihydroisocoumarin (<bold>132</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TLC-autobiography/<italic>Aspergillus niger</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 12.5 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TLC-autobiography/<italic>Cladosporium herbarum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 12.5 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Bacillus subtilis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 3.13 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Pseudomonas syringae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">100 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 3.13 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B55-molecules-25-00395" ref-type="bibr">55</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Periplanetin D (<bold>137</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antivirus </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Spectrophotometer/Anti-TMV</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15.5% GI (20 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 28.6% GI (20 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B44-molecules-25-00395" ref-type="bibr">44</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Pestalactone C (<bold>138</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Candida glabrata</italic> (ATCC 90030)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3.49 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 0.25 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B22-molecules-25-00395" ref-type="bibr">22</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(6,8-Dihydroxy-3-methyl-1-oxo-1H-isochromen-4-yl)methyl 3-methylbutanoate (<bold>150</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">140.8 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin F (<bold>153</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution//<break></break><italic>S</italic>. <italic>aureus</italic> (ATCC 27154)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12.5 μM (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.160 μM (MIC) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td rowspan="8" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Penicisimpin A (<bold>157</bold>)<break></break>3-(R)-6,8-Dihydroxy-7-methyl-3-pentylisochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Micrococcus luteus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 1 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Pseudomonas aeruginosa</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 4 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio alginolyticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 0.5 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio harveyi</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio parahaemolyticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Colletotrichum gloeosprioides</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 8 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Phytophthora parasitica</italic> var. nicotianae</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 16 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td rowspan="9" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Penicisimpin B (<bold>158</bold>)<break></break>3-(R)-6,8-Dihydroxy-3-pentylisochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Aeromonas hydrophilia</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 32 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Micrococcus luteus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">64 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 1 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Pseudomonas aeruginos</italic>a</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 4 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio alginolyticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 0.5 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio harveyi</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio parahaemolyticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Colletotrichum gloeosprioides</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 8 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Phytophthora parasitica</italic> var. nicotianae</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 16 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td rowspan="8" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Penicisimpin C (<bold>159</bold>)<break></break>3-(S)-6,8-Dihydroxy-7-methyl-3-(pent-1-enyl)isochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Aeromonas hydrophilia</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 32 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Micrococcus luteus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 1 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Pseudomonas aeruginosa</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 4 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio alginolyticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 0.5 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio harveyi</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Vibrio parahaemolyticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chloramphenicol 2 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Well diffusion method/<italic>Colletotrichum gloeosprioides</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 8 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fusarentin<break></break>6,7-dimethyl ether (<bold>160</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ORAC</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">14.4 µM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Trolox 1 µM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Fusarentin 6-methyl ether (<bold>161</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DPPH</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">16.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ascorbic acid 21.2 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ORAC</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.4 µM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Trolox 1 µM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td rowspan="11" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Monocerin (<bold>165</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 18 mm (IZD)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Bacillus megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 14 mm (IZD)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">23 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Actidione 35 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antialgal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Chlorella fusca</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Microbroth dilution/<italic>E. coli</italic> (ATCC 25922)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15.62 μg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Pseudomonas aeruginosa</italic> (ATCC 27853)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15.62 μg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>S. aureus</italic> (ATCC 25923)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15.62 μg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>B. subtilis</italic> (ATCC 6633)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15.62 μg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>Salmonella Typhimurium</italic> (ATCC14028)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">31.25 μg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B59-molecules-25-00395" ref-type="bibr">59</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ORAC</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10.8 µM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Trolox 1 µM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antimalarial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Microculture radioisotope/<italic>P. falciparum</italic> (K1)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.68 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dihydroartemisinin 0.0004 µM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">7-<italic>O</italic>-Demethylmonocerin (<bold>166</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">XXO </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">52.6 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DPPH</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">23.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ascorbic acid 21.2 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">ORAC</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">11.5 µM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Trolox 1 µM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DPPH</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">38 μM (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ascorbic acid 39 μM (EC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B64-molecules-25-00395" ref-type="bibr">64</xref>]</td></tr><tr><td rowspan="3" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(12R)-12-Hydroxymonocerin (<bold>167</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Actidione 35 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antialgal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Chlorella fusca</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>F. oxysporum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 0.63 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(11R)-Hydroxymonocerin (<bold>168</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antimalarial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Microculture radioisotope/<italic>P. falciparum</italic> (K1) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7.7 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dihydroartemisinin 0.004 µM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B46-molecules-25-00395" ref-type="bibr">46</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(12S)-Hydroxymonocerin (<bold>169</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 18 mm (IZD)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>B. megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 14 mm (IZD)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Actidione 35 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antialgal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Chlorella</italic><italic>fusca</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B49-molecules-25-00395" ref-type="bibr">49</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Exserolide C (<bold>177</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>F. oxysporum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Amphotericin B 0.63 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alternariol (<bold>188</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antimicrobial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>M. tetragenus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Streptomycin 3.125 µg/mL (MIC)<break></break>Acheomycin 3.125 µg/mL (MIC)<break></break>Ampicillin 3.125 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B57-molecules-25-00395" ref-type="bibr">57</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Alternariol 5-<italic>O</italic>-methyl ether (<bold>189</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antimicrobial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>B. megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12.5 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Streptomycin 3.125 µg/mL (MIC)<break></break>Acheomycin 3.125 µg/mL (MIC)<break></break>Ampicillin 3.125 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B57-molecules-25-00395" ref-type="bibr">57</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Cycloepoxylactone (<bold>197</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Bacillus megaterium</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5 mm (GI)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 14 mm (GI)<break></break>Tetracycline 18 mm (GI)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Agar diffusion/<italic>Microbotryum violaceum</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 mm (IZD)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Nystatin 20 mm (IZD)<break></break>Actidione 50 mm (IZD)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B42-molecules-25-00395" ref-type="bibr">42</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Exserolide F (<bold>201</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>B. subtilis</italic> (ATCC 6633</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ampicillin 1.25 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>S. aureus</italic> (CGMCC 1.2465)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ampicillin 0.16 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>S. pneumoniae</italic> (CGMCC 1.1692)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">10 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ampicillin 10 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>E. coli</italic> (CGMCC 1.2340)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20 µg/mL (MIC)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gentamicin 2.5 µg/mL (MIC)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B60-molecules-25-00395" ref-type="bibr">60</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Isocitreoisocoumarinol (<bold>202</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.98 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"> tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(+) Citreoisocoumarin (<bold>203</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.03 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(+)-6-Methylcitreoisocoumarin (<bold>204</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">38% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.98 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Citreoisocoumarinol (<bold>205</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.91 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mucorisocoumarin A (<bold>207</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.88 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Mucorisocoumarin B (<bold>208</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.03 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin A (<bold>209</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.93 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin B (<bold>210</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2.95 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin C (<bold>211</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.46 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Aspergillumarin A (<bold>212</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">38.1 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>S. albus</italic> (ATCC 8799)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12.5 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.312 μM (MIC<sub>50</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Aspergillumarin B (<bold>213</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">193.1 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/S. albus (ATCC 8799)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12.5 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.312 μM (MIC<sub>50</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B52-molecules-25-00395" ref-type="bibr">52</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin B (<bold>214</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">431.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicimarin C (<bold>215</bold>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">266.3 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(R)-3-(R)-4,5-Dihydroxypentyl)-8-hydroxyisochroman-1-one (<bold>216</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">162.5 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5,6-Dihydroxy-3-(4-ydroxypentyl)isochroman-1-one (<bold>217</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">142.1 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B62-molecules-25-00395" ref-type="bibr">62</xref>]</td></tr><tr><td rowspan="8" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Dichlorodiaportin (<bold>220</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colourmetric/NO </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">67.2 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Indomethacin 37.5 μM (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Staphylococcus aureus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>B. subtilis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Klebsiella</italic><italic>pneumoniae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Acinetobacter calcoaceticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Broth dilution/<italic>Colletotrichum musae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">150 μg/mL (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Carbendazim 6.25 μg/mL (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Broth dilution/<italic>Rhizoctonia solani</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">150 μg/mL (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Carbendazim 6.25 μg/mL (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td rowspan="6" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Desmethyldichlorodiaportin (<bold>221</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colourmetric/NO </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">33.6 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Indomethacin 37.5 μM (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>S. aureus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>B. subtilis</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Klebsiella pneumoniae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Acinetobacter calcoaceticus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin D (<bold>222</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">41% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin E (<bold>223</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">158.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin F (<bold>224</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">110.3 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin G (<bold>225</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">40.5 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin H (<bold>226</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">43% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin I (<bold>227</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">78.1 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin J (<bold>228</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">45.1 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3-[(R)-3,3-Dichloro-2-hydroxypropyl]-8-hydroxy-<break></break>6-methoxy-1H-isochromen-1-one (<bold>229</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">102.4 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 958.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(+)-Diaporthin (<bold>230</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">33% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Diaportinol (<bold>231</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.85 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">(+)-(10R)-7-Hydroxy-3-(2-hydroxy-propyl)-5,6-dimethylisochromen-1-one (<bold>232</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>B. subtilis</italic> (ATCC 6633)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">19.2 μg/mL (MIC<sub>80</sub>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicillin 0.9 μg/mL (MIC<sub>80</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Trichophyton rubrum</italic> (ATCC 28189)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">32 μg/mL (MIC<sub>80</sub>) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Fluconazole 1 μg/mL (MIC<sub>80</sub>) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B63-molecules-25-00395" ref-type="bibr">63</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peyroisocoumarin D (<bold>233</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">2.28 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Orthosporin (<bold>234</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.58 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin A (<bold>251</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Anti-TMV </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Half-leaf method</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">28.6% (Inhibition rate) </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ningnanmycin 31.5% (Inhibition rate) </td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin C (<bold>258</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">95% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin A (<bold>261</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DPPH</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">125 μM (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ascorbic acid 35 μM (EC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin B (<bold>262</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">87.8 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose628.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin C (<bold>263</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DPPH</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">138 μM (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ascorbic acid 35 μM (EC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin E (<bold>265</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">52.3 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 628.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Asperisocoumarin F (<bold>266</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">95.6 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 628.3 μM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B76-molecules-25-00395" ref-type="bibr">76</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin A (<bold>267</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">18% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin B (<bold>268</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">α-Glucosidase inhibitory </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Chromogenic </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">23% Inhibition (200 μM)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Acarbose 19% Inhibition (200 μM)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Demethylcitreoviranol (<bold>286</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.06 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Citreoviranol (<bold>287</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antioxidant </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Luciferase</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.44 mM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">tBHQ 4.29 mM (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B65-molecules-25-00395" ref-type="bibr">65</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Dichlorodiaportinolide (<bold>290</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Broth dilution/<italic>Colletotrichum musae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">25 μg/mL (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Carbendazim 6.25 μg/mL (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antifungal</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Broth dilution/<italic>Rhizoctonia solani</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6.25 μg/mL (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Carbendazim 6.25 μg/mL (IC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B66-molecules-25-00395" ref-type="bibr">66</xref>]</td></tr><tr><td rowspan="4" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Dichlorodiaportintone (<bold>291</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colourmetric/NO </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">41.5 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Indomethacin 37.5 μM (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>S. aureus</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>E. coli</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Antibacterial </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colorimetric broth microdilution/<italic>Klebsiella pneumoniae</italic></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">50 μg/mL (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Ciprofloxacin 0.25 μg/mL (MIC<sub>50</sub>)<break></break>Gentamicin 0.1 μg/mL (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Desmethyldichlorodiaportintone (<bold>292</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colourmetric/NO </td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">15.8 μM (MIC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Indomethacin 37.5 μM (MIC<sub>50</sub>)</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B37-molecules-25-00395" ref-type="bibr">37</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Botryoisocoumarin A (<bold>293</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Anti-inflammatory</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colourmetric/COX-2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6.51 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">-</td><td colspan="2" align="center" valign="middle" style="border-bottom:solid thin" rowspan="1">[<xref rid="B36-molecules-25-00395" ref-type="bibr">36</xref>]</td></tr></tbody></table></table-wrap><table-wrap id="molecules-25-00395-t003" orientation="portrait" position="float"><object-id pub-id-type="pii">molecules-25-00395-t003_Table 3</object-id><label>Table 3</label><caption><p>Cytotoxic activity of the most active fungal isocoumarins.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Compound Name</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Assay, Cell Line</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Cytotoxicity Results</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Positive Control</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Referencs</th></tr></thead><tbody><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicisimpin A (<bold>157</bold>)<break></break>3-(<italic>R</italic>)-6,8-Dihydroxy-7-methyl-3-pentylisochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Brine shrimp (<italic>Artemia salina</italic>) lethality</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7.7 µg/mL (LD<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colchicine 16.5 µg/mL (LD<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicisimpin B (<bold>158</bold>)<break></break>3-(<italic>R</italic>)-6,8-Dihydroxy-3-pentylisochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">36.4 µg/mL (LD<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colchicine 16.5 µg/mL (LD<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Penicisimpin C (<bold>159</bold>)<break></break>3-(<italic>S</italic>)-6,8-Dihydroxy-7-methyl-3-(pent-1-enyl)isochroman-1-one</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">18.6 µg/mL (LD<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Colchicine 16.5 µg/mL (LD<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B58-molecules-25-00395" ref-type="bibr">58</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7-<italic>O</italic>-Demethylmonocerin (<bold>166</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTT/HepG2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">23.7 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Etoposide 15.8 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B80-molecules-25-00395" ref-type="bibr">80</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin A (<bold>274</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">43.70 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 0.32 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dichlorodiaportinol A (<bold>289</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">39.6 μg/mL (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 5.2 μg/mL(IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B79-molecules-25-00395" ref-type="bibr">79</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">(+) Citreoisocoumarin (<bold>203</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTT/L5178Y</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">99.5% GI (10 μg/mL)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.1% EGMME/DMSO</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Desmethyldiaportinol (<bold>219</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">7.3 μg/mL (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Kahalalide F 6.4 μg/mL (EC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Desmethyldichlorodiaportin (<bold>221</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">41.4% GI (10 μg/mL)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.1% EGMME/DMSO</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B40-molecules-25-00395" ref-type="bibr">40</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,6′-Dinor-bipenicilisorin (<bold>259</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">13% GI (10 μg/mL)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gerfelin 85% GI (10 μg/mL)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B81-molecules-25-00395" ref-type="bibr">81</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">6,6′,9′-Trinor-bipenicilisorin (<bold>260</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">33% GI (10 μg/mL)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gerfelin 85% GI (10 μg/mL)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B81-molecules-25-00395" ref-type="bibr">81</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin A (<bold>251</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTT/MCF7</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">3.8 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Taxol 0.1 μM (IC<sub>50</sub>) </td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin D (<bold>252</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8.0 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Taxol</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B89-molecules-25-00395" ref-type="bibr">89</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Dichlorodiaportinol A (<bold>289</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">17.8 μg/mL (EC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 5.3 μg/mL (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B79-molecules-25-00395" ref-type="bibr">79</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Peniisocoumarin G (<bold>225</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTT/MptpB</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">20.1 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Oleanolic acid 22.1 µM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B31-molecules-25-00395" ref-type="bibr">31</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin A (<bold>251</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTT/A549</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4.0 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Taxol 0.02 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B93-molecules-25-00395" ref-type="bibr">93</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Versicoumarin D (<bold>252</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTT/A549</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5.8 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Taxol</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B89-molecules-25-00395" ref-type="bibr">89</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin A (<bold>274</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTS/MDA-MB-435</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5.08 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 0.26 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin B (<bold>275</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">4.98 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 0.26 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin A (<bold>274</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTS/MCF10A</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">11.34 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 0.13 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin B (<bold>275</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">21.40 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 0.13 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Aspergisocoumrin A (<bold>274</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">MTS/H460</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">21.53 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Epirubicin 0.12 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B73-molecules-25-00395" ref-type="bibr">73</xref>]</td></tr><tr><td rowspan="2" align="left" valign="middle" style="border-bottom:solid thin" colspan="1">Isocoumarindole A (<bold>296</bold>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CCK colorimetric/MIA-PACA-2</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.63 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gemcitabine 1.02 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]</td></tr><tr><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CCK colorimetric/ASPC-1</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5.53 μM (IC<sub>50</sub>)</td><td align="left" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Gemcitabine 20.10 μM (IC<sub>50</sub>)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">[<xref rid="B29-molecules-25-00395" ref-type="bibr">29</xref>]</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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