Non-Analgesic Symptomatic or Disease—Modifying Potential of TRPA1
Identifieur interne : 000A61 ( Pmc/Corpus ); précédent : 000A60; suivant : 000A62Non-Analgesic Symptomatic or Disease—Modifying Potential of TRPA1
Auteurs : Stefan Heber ; Michael J. M. FischerSource :
- Medical Sciences [ 2076-3271 ] ; 2019.
Abstract
TRPA1, a versatile ion channel of the Transient Receptor Potential (TRP) channel family, detects a large variety of chemicals and can contribute to signal processing of other stimuli, e.g., due to its sensitivity to cytosolic calcium elevation or phosphoinositolphosphate modulation. At first, TRPA1 was found on sensory neurons, where it can act as a sensor for potential or actual tissue damage that ultimately may elicit pain or itch as warning symptoms. This review provides an update regarding the analgesic and antipruritic potential of TRPA1 modulation and the respective clinical trials. Furthermore, TRPA1 has been found in an increasing amount of other cell types. Therefore, the main focus of the review is to discuss the non-analgesic and particularly the disease-modifying potential of TRPA1. This includes diseases of the respiratory system, cancer, ischemia, allergy, diabetes, and the gastrointestinal system. The involvement of TRPA1 in the respective pathophysiological cascades is so far mainly based on pre-clinical data.
Url:
DOI: 10.3390/medsci7100099
PubMed: 31547502
PubMed Central: 6836032
Links to Exploration step
PMC:6836032Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>TRPA1, a versatile ion channel of the Transient Receptor Potential (TRP) channel family, detects a large variety of chemicals and can contribute to signal processing of other stimuli, e.g., due to its sensitivity to cytosolic calcium elevation or phosphoinositolphosphate modulation. At first, TRPA1 was found on sensory neurons, where it can act as a sensor for potential or actual tissue damage that ultimately may elicit pain or itch as warning symptoms. This review provides an update regarding the analgesic and antipruritic potential of TRPA1 modulation and the respective clinical trials. Furthermore, TRPA1 has been found in an increasing amount of other cell types. Therefore, the main focus of the review is to discuss the non-analgesic and particularly the disease-modifying potential of TRPA1. This includes diseases of the respiratory system, cancer, ischemia, allergy, diabetes, and the gastrointestinal system. The involvement of TRPA1 in the respective pathophysiological cascades is so far mainly based on pre-clinical data.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jaquemar, D" uniqKey="Jaquemar D">D. Jaquemar</name>
</author>
<author><name sortKey="Schenker, T" uniqKey="Schenker T">T. Schenker</name>
</author>
<author><name sortKey="Trueb, B" uniqKey="Trueb B">B. Trueb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jordt, S E" uniqKey="Jordt S">S.-E. Jordt</name>
</author>
<author><name sortKey="Bautista, D M" uniqKey="Bautista D">D.M. Bautista</name>
</author>
<author><name sortKey="Chuang, H H" uniqKey="Chuang H">H.-H. Chuang</name>
</author>
<author><name sortKey="Mckemy, D D" uniqKey="Mckemy D">D.D. McKemy</name>
</author>
<author><name sortKey="Zygmunt, P M" uniqKey="Zygmunt P">P.M. Zygmunt</name>
</author>
<author><name sortKey="Hogest Tt, E D" uniqKey="Hogest Tt E">E.D. Högestätt</name>
</author>
<author><name sortKey="Meng, I D" uniqKey="Meng I">I.D. Meng</name>
</author>
<author><name sortKey="Julius, D" uniqKey="Julius D">D. Julius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kwan, K Y" uniqKey="Kwan K">K.Y. Kwan</name>
</author>
<author><name sortKey="Allchorne, A J" uniqKey="Allchorne A">A.J. Allchorne</name>
</author>
<author><name sortKey="Vollrath, M A" uniqKey="Vollrath M">M.A. Vollrath</name>
</author>
<author><name sortKey="Christensen, A P" uniqKey="Christensen A">A.P. Christensen</name>
</author>
<author><name sortKey="Zhang, D S" uniqKey="Zhang D">D.-S. Zhang</name>
</author>
<author><name sortKey="Woolf, C J" uniqKey="Woolf C">C.J. Woolf</name>
</author>
<author><name sortKey="Corey, D P" uniqKey="Corey D">D.P. Corey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paulsen, C E" uniqKey="Paulsen C">C.E. Paulsen</name>
</author>
<author><name sortKey="Armache, J P" uniqKey="Armache J">J.-P. Armache</name>
</author>
<author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name>
</author>
<author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y. Cheng</name>
</author>
<author><name sortKey="Julius, D" uniqKey="Julius D">D. Julius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Viana, F" uniqKey="Viana F">F. Viana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meents, J E" uniqKey="Meents J">J.E. Meents</name>
</author>
<author><name sortKey="Ciotu, C I" uniqKey="Ciotu C">C.I. Ciotu</name>
</author>
<author><name sortKey="Fischer, M J M" uniqKey="Fischer M">M.J.M. Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Hackos, D H" uniqKey="Hackos D">D.H. Hackos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koivisto, A" uniqKey="Koivisto A">A. Koivisto</name>
</author>
<author><name sortKey="Jalava, N" uniqKey="Jalava N">N. Jalava</name>
</author>
<author><name sortKey="Bratty, R" uniqKey="Bratty R">R. Bratty</name>
</author>
<author><name sortKey="Pertovaara, A" uniqKey="Pertovaara A">A. Pertovaara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weyer Menkhoff, I" uniqKey="Weyer Menkhoff I">I. Weyer-Menkhoff</name>
</author>
<author><name sortKey="Lotsch, J" uniqKey="Lotsch J">J. Lötsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcnamara, C R" uniqKey="Mcnamara C">C.R. McNamara</name>
</author>
<author><name sortKey="Mandel Brehm, J" uniqKey="Mandel Brehm J">J. Mandel-Brehm</name>
</author>
<author><name sortKey="Bautista, D M" uniqKey="Bautista D">D.M. Bautista</name>
</author>
<author><name sortKey="Siemens, J" uniqKey="Siemens J">J. Siemens</name>
</author>
<author><name sortKey="Deranian, K L" uniqKey="Deranian K">K.L. Deranian</name>
</author>
<author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name>
</author>
<author><name sortKey="Hayward, N J" uniqKey="Hayward N">N.J. Hayward</name>
</author>
<author><name sortKey="Chong, J A" uniqKey="Chong J">J.A. Chong</name>
</author>
<author><name sortKey="Julius, D" uniqKey="Julius D">D. Julius</name>
</author>
<author><name sortKey="Moran, M M" uniqKey="Moran M">M.M. Moran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klionsky, L" uniqKey="Klionsky L">L. Klionsky</name>
</author>
<author><name sortKey="Tamir, R" uniqKey="Tamir R">R. Tamir</name>
</author>
<author><name sortKey="Gao, B" uniqKey="Gao B">B. Gao</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
<author><name sortKey="Immke, D C" uniqKey="Immke D">D.C. Immke</name>
</author>
<author><name sortKey="Nishimura, N" uniqKey="Nishimura N">N. Nishimura</name>
</author>
<author><name sortKey="Gavva, N R" uniqKey="Gavva N">N.R. Gavva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiao, B" uniqKey="Xiao B">B. Xiao</name>
</author>
<author><name sortKey="Dubin, A E" uniqKey="Dubin A">A.E. Dubin</name>
</author>
<author><name sortKey="Bursulaya, B" uniqKey="Bursulaya B">B. Bursulaya</name>
</author>
<author><name sortKey="Viswanath, V" uniqKey="Viswanath V">V. Viswanath</name>
</author>
<author><name sortKey="Jegla, T J" uniqKey="Jegla T">T.J. Jegla</name>
</author>
<author><name sortKey="Patapoutian, A" uniqKey="Patapoutian A">A. Patapoutian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petrus, M" uniqKey="Petrus M">M. Petrus</name>
</author>
<author><name sortKey="Peier, A M" uniqKey="Peier A">A.M. Peier</name>
</author>
<author><name sortKey="Bandell, M" uniqKey="Bandell M">M. Bandell</name>
</author>
<author><name sortKey="Hwang, S W" uniqKey="Hwang S">S.W. Hwang</name>
</author>
<author><name sortKey="Huynh, T" uniqKey="Huynh T">T. Huynh</name>
</author>
<author><name sortKey="Olney, N" uniqKey="Olney N">N. Olney</name>
</author>
<author><name sortKey="Jegla, T" uniqKey="Jegla T">T. Jegla</name>
</author>
<author><name sortKey="Patapoutian, A" uniqKey="Patapoutian A">A. Patapoutian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ryckmans, T" uniqKey="Ryckmans T">T. Ryckmans</name>
</author>
<author><name sortKey="Aubdool, A A" uniqKey="Aubdool A">A.A. Aubdool</name>
</author>
<author><name sortKey="Bodkin, J V" uniqKey="Bodkin J">J.V. Bodkin</name>
</author>
<author><name sortKey="Cox, P" uniqKey="Cox P">P. Cox</name>
</author>
<author><name sortKey="Brain, S D" uniqKey="Brain S">S.D. Brain</name>
</author>
<author><name sortKey="Dupont, T" uniqKey="Dupont T">T. Dupont</name>
</author>
<author><name sortKey="Fairman, E" uniqKey="Fairman E">E. Fairman</name>
</author>
<author><name sortKey="Hashizume, Y" uniqKey="Hashizume Y">Y. Hashizume</name>
</author>
<author><name sortKey="Ishii, N" uniqKey="Ishii N">N. Ishii</name>
</author>
<author><name sortKey="Kato, T" uniqKey="Kato T">T. Kato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takaya, J" uniqKey="Takaya J">J. Takaya</name>
</author>
<author><name sortKey="Mio, K" uniqKey="Mio K">K. Mio</name>
</author>
<author><name sortKey="Shiraishi, T" uniqKey="Shiraishi T">T. Shiraishi</name>
</author>
<author><name sortKey="Kurokawa, T" uniqKey="Kurokawa T">T. Kurokawa</name>
</author>
<author><name sortKey="Otsuka, S" uniqKey="Otsuka S">S. Otsuka</name>
</author>
<author><name sortKey="Mori, Y" uniqKey="Mori Y">Y. Mori</name>
</author>
<author><name sortKey="Uesugi, M" uniqKey="Uesugi M">M. Uesugi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Namer, B" uniqKey="Namer B">B. Namer</name>
</author>
<author><name sortKey="Seifert, F" uniqKey="Seifert F">F. Seifert</name>
</author>
<author><name sortKey="Handwerker, H O" uniqKey="Handwerker H">H.O. Handwerker</name>
</author>
<author><name sortKey="Maihofner, C" uniqKey="Maihofner C">C. Maihöfner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klein, A H" uniqKey="Klein A">A.H. Klein</name>
</author>
<author><name sortKey="Carstens, M I" uniqKey="Carstens M">M.I. Carstens</name>
</author>
<author><name sortKey="Zanotto, K L" uniqKey="Zanotto K">K.L. Zanotto</name>
</author>
<author><name sortKey="Sawyer, C M" uniqKey="Sawyer C">C.M. Sawyer</name>
</author>
<author><name sortKey="Ivanov, M" uniqKey="Ivanov M">M. Ivanov</name>
</author>
<author><name sortKey="Cheung, S" uniqKey="Cheung S">S. Cheung</name>
</author>
<author><name sortKey="Carstens, E" uniqKey="Carstens E">E. Carstens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andersen, H H" uniqKey="Andersen H">H.H. Andersen</name>
</author>
<author><name sortKey="Gazerani, P" uniqKey="Gazerani P">P. Gazerani</name>
</author>
<author><name sortKey="Arendt Nielsen, L" uniqKey="Arendt Nielsen L">L. Arendt-Nielsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwarz, M G" uniqKey="Schwarz M">M.G. Schwarz</name>
</author>
<author><name sortKey="Namer, B" uniqKey="Namer B">B. Namer</name>
</author>
<author><name sortKey="Reeh, P W" uniqKey="Reeh P">P.W. Reeh</name>
</author>
<author><name sortKey="Fischer, M J M" uniqKey="Fischer M">M.J.M. Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heber, S" uniqKey="Heber S">S. Heber</name>
</author>
<author><name sortKey="Gold Binder, M" uniqKey="Gold Binder M">M. Gold-Binder</name>
</author>
<author><name sortKey="Ciotu, C I" uniqKey="Ciotu C">C.I. Ciotu</name>
</author>
<author><name sortKey="Witek, M" uniqKey="Witek M">M. Witek</name>
</author>
<author><name sortKey="Ninidze, N" uniqKey="Ninidze N">N. Ninidze</name>
</author>
<author><name sortKey="Kress, H G" uniqKey="Kress H">H.-G. Kress</name>
</author>
<author><name sortKey="Fischer, M J M" uniqKey="Fischer M">M.J.M. Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bautista, D M" uniqKey="Bautista D">D.M. Bautista</name>
</author>
<author><name sortKey="Jordt, S E" uniqKey="Jordt S">S.-E. Jordt</name>
</author>
<author><name sortKey="Nikai, T" uniqKey="Nikai T">T. Nikai</name>
</author>
<author><name sortKey="Tsuruda, P R" uniqKey="Tsuruda P">P.R. Tsuruda</name>
</author>
<author><name sortKey="Read, A J" uniqKey="Read A">A.J. Read</name>
</author>
<author><name sortKey="Poblete, J" uniqKey="Poblete J">J. Poblete</name>
</author>
<author><name sortKey="Yamoah, E N" uniqKey="Yamoah E">E.N. Yamoah</name>
</author>
<author><name sortKey="Basbaum, A I" uniqKey="Basbaum A">A.I. Basbaum</name>
</author>
<author><name sortKey="Julius, D" uniqKey="Julius D">D. Julius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Kang, D" uniqKey="Kang D">D. Kang</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name>
</author>
<author><name sortKey="Lake, M" uniqKey="Lake M">M. Lake</name>
</author>
<author><name sortKey="Hogan, J O" uniqKey="Hogan J">J.O. Hogan</name>
</author>
<author><name sortKey="Sun, C" uniqKey="Sun C">C. Sun</name>
</author>
<author><name sortKey="Walter, K" uniqKey="Walter K">K. Walter</name>
</author>
<author><name sortKey="Yao, B" uniqKey="Yao B">B. Yao</name>
</author>
<author><name sortKey="Kim, D" uniqKey="Kim D">D. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De La Roche, J" uniqKey="De La Roche J">J. de la Roche</name>
</author>
<author><name sortKey="Eberhardt, M J" uniqKey="Eberhardt M">M.J. Eberhardt</name>
</author>
<author><name sortKey="Klinger, A B" uniqKey="Klinger A">A.B. Klinger</name>
</author>
<author><name sortKey="Stanslowsky, N" uniqKey="Stanslowsky N">N. Stanslowsky</name>
</author>
<author><name sortKey="Wegner, F" uniqKey="Wegner F">F. Wegner</name>
</author>
<author><name sortKey="Koppert, W" uniqKey="Koppert W">W. Koppert</name>
</author>
<author><name sortKey="Reeh, P W" uniqKey="Reeh P">P.W. Reeh</name>
</author>
<author><name sortKey="Lampert, A" uniqKey="Lampert A">A. Lampert</name>
</author>
<author><name sortKey="Fischer, M J M" uniqKey="Fischer M">M.J.M. Fischer</name>
</author>
<author><name sortKey="Leffler, A" uniqKey="Leffler A">A. Leffler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gracheva, E O" uniqKey="Gracheva E">E.O. Gracheva</name>
</author>
<author><name sortKey="Ingolia, N T" uniqKey="Ingolia N">N.T. Ingolia</name>
</author>
<author><name sortKey="Kelly, Y M" uniqKey="Kelly Y">Y.M. Kelly</name>
</author>
<author><name sortKey="Cordero Morales, J F" uniqKey="Cordero Morales J">J.F. Cordero-Morales</name>
</author>
<author><name sortKey="Hollopeter, G" uniqKey="Hollopeter G">G. Hollopeter</name>
</author>
<author><name sortKey="Chesler, A T" uniqKey="Chesler A">A.T. Chesler</name>
</author>
<author><name sortKey="Sanchez, E E" uniqKey="Sanchez E">E.E. Sánchez</name>
</author>
<author><name sortKey="Perez, J C" uniqKey="Perez J">J.C. Perez</name>
</author>
<author><name sortKey="Weissman, J S" uniqKey="Weissman J">J.S. Weissman</name>
</author>
<author><name sortKey="Julius, D" uniqKey="Julius D">D. Julius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakatsuka, K" uniqKey="Nakatsuka K">K. Nakatsuka</name>
</author>
<author><name sortKey="Gupta, R" uniqKey="Gupta R">R. Gupta</name>
</author>
<author><name sortKey="Saito, S" uniqKey="Saito S">S. Saito</name>
</author>
<author><name sortKey="Banzawa, N" uniqKey="Banzawa N">N. Banzawa</name>
</author>
<author><name sortKey="Takahashi, K" uniqKey="Takahashi K">K. Takahashi</name>
</author>
<author><name sortKey="Tominaga, M" uniqKey="Tominaga M">M. Tominaga</name>
</author>
<author><name sortKey="Ohta, T" uniqKey="Ohta T">T. Ohta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saito, S" uniqKey="Saito S">S. Saito</name>
</author>
<author><name sortKey="Tominaga, M" uniqKey="Tominaga M">M. Tominaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bianchi, B R" uniqKey="Bianchi B">B.R. Bianchi</name>
</author>
<author><name sortKey="Zhang, X F" uniqKey="Zhang X">X.-F. Zhang</name>
</author>
<author><name sortKey="Reilly, R M" uniqKey="Reilly R">R.M. Reilly</name>
</author>
<author><name sortKey="Kym, P R" uniqKey="Kym P">P.R. Kym</name>
</author>
<author><name sortKey="Yao, B B" uniqKey="Yao B">B.B. Yao</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borkum, J M" uniqKey="Borkum J">J.M. Borkum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kunkler, P E" uniqKey="Kunkler P">P.E. Kunkler</name>
</author>
<author><name sortKey="Ballard, C J" uniqKey="Ballard C">C.J. Ballard</name>
</author>
<author><name sortKey="Oxford, G S" uniqKey="Oxford G">G.S. Oxford</name>
</author>
<author><name sortKey="Hurley, J H" uniqKey="Hurley J">J.H. Hurley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, P J" uniqKey="Anderson P">P.J. Anderson</name>
</author>
<author><name sortKey="Lau, G S" uniqKey="Lau G">G.S. Lau</name>
</author>
<author><name sortKey="Taylor, W R" uniqKey="Taylor W">W.R. Taylor</name>
</author>
<author><name sortKey="Critchley, J A" uniqKey="Critchley J">J.A. Critchley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lima, A M" uniqKey="Lima A">A.M. Lima</name>
</author>
<author><name sortKey="Sapienza, G B" uniqKey="Sapienza G">G.B. Sapienza</name>
</author>
<author><name sortKey="Giraud, V O" uniqKey="Giraud V">V.O. Giraud</name>
</author>
<author><name sortKey="Fragoso, Y D" uniqKey="Fragoso Y">Y.D. Fragoso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benemei, S" uniqKey="Benemei S">S. Benemei</name>
</author>
<author><name sortKey="Fusi, C" uniqKey="Fusi C">C. Fusi</name>
</author>
<author><name sortKey="Trevisan, G" uniqKey="Trevisan G">G. Trevisan</name>
</author>
<author><name sortKey="Geppetti, P" uniqKey="Geppetti P">P. Geppetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="So, K" uniqKey="So K">K. So</name>
</author>
<author><name sortKey="Tei, Y" uniqKey="Tei Y">Y. Tei</name>
</author>
<author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name>
</author>
<author><name sortKey="Miyake, T" uniqKey="Miyake T">T. Miyake</name>
</author>
<author><name sortKey="Hiyama, H" uniqKey="Hiyama H">H. Hiyama</name>
</author>
<author><name sortKey="Shirakawa, H" uniqKey="Shirakawa H">H. Shirakawa</name>
</author>
<author><name sortKey="Imai, S" uniqKey="Imai S">S. Imai</name>
</author>
<author><name sortKey="Mori, Y" uniqKey="Mori Y">Y. Mori</name>
</author>
<author><name sortKey="Nakagawa, T" uniqKey="Nakagawa T">T. Nakagawa</name>
</author>
<author><name sortKey="Matsubara, K" uniqKey="Matsubara K">K. Matsubara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aubdool, A A" uniqKey="Aubdool A">A.A. Aubdool</name>
</author>
<author><name sortKey="Graepel, R" uniqKey="Graepel R">R. Graepel</name>
</author>
<author><name sortKey="Kodji, X" uniqKey="Kodji X">X. Kodji</name>
</author>
<author><name sortKey="Alawi, K M" uniqKey="Alawi K">K.M. Alawi</name>
</author>
<author><name sortKey="Bodkin, J V" uniqKey="Bodkin J">J.V. Bodkin</name>
</author>
<author><name sortKey="Srivastava, S" uniqKey="Srivastava S">S. Srivastava</name>
</author>
<author><name sortKey="Gentry, C" uniqKey="Gentry C">C. Gentry</name>
</author>
<author><name sortKey="Heads, R" uniqKey="Heads R">R. Heads</name>
</author>
<author><name sortKey="Grant, A D" uniqKey="Grant A">A.D. Grant</name>
</author>
<author><name sortKey="Fernandes, E S" uniqKey="Fernandes E">E.S. Fernandes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, X" uniqKey="Dong X">X. Dong</name>
</author>
<author><name sortKey="Dong, X" uniqKey="Dong X">X. Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z. Xie</name>
</author>
<author><name sortKey="Hu, H" uniqKey="Hu H">H. Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moore, C" uniqKey="Moore C">C. Moore</name>
</author>
<author><name sortKey="Gupta, R" uniqKey="Gupta R">R. Gupta</name>
</author>
<author><name sortKey="Jordt, S E" uniqKey="Jordt S">S.-E. Jordt</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Liedtke, W B" uniqKey="Liedtke W">W.B. Liedtke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, S R" uniqKey="Wilson S">S.R. Wilson</name>
</author>
<author><name sortKey="Nelson, A M" uniqKey="Nelson A">A.M. Nelson</name>
</author>
<author><name sortKey="Batia, L" uniqKey="Batia L">L. Batia</name>
</author>
<author><name sortKey="Morita, T" uniqKey="Morita T">T. Morita</name>
</author>
<author><name sortKey="Estandian, D" uniqKey="Estandian D">D. Estandian</name>
</author>
<author><name sortKey="Owens, D M" uniqKey="Owens D">D.M. Owens</name>
</author>
<author><name sortKey="Lumpkin, E A" uniqKey="Lumpkin E">E.A. Lumpkin</name>
</author>
<author><name sortKey="Bautista, D M" uniqKey="Bautista D">D.M. Bautista</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, Q" uniqKey="Han Q">Q. Han</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D. Liu</name>
</author>
<author><name sortKey="Convertino, M" uniqKey="Convertino M">M. Convertino</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name>
</author>
<author><name sortKey="Jiang, C" uniqKey="Jiang C">C. Jiang</name>
</author>
<author><name sortKey="Kim, Y H" uniqKey="Kim Y">Y.H. Kim</name>
</author>
<author><name sortKey="Luo, X" uniqKey="Luo X">X. Luo</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name>
</author>
<author><name sortKey="Nackley, A" uniqKey="Nackley A">A. Nackley</name>
</author>
<author><name sortKey="Dokholyan, N V" uniqKey="Dokholyan N">N.V. Dokholyan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Esancy, K" uniqKey="Esancy K">K. Esancy</name>
</author>
<author><name sortKey="Condon, L" uniqKey="Condon L">L. Condon</name>
</author>
<author><name sortKey="Feng, J" uniqKey="Feng J">J. Feng</name>
</author>
<author><name sortKey="Kimball, C" uniqKey="Kimball C">C. Kimball</name>
</author>
<author><name sortKey="Curtright, A" uniqKey="Curtright A">A. Curtright</name>
</author>
<author><name sortKey="Dhaka, A" uniqKey="Dhaka A">A. Dhaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsagareli, M G" uniqKey="Tsagareli M">M.G. Tsagareli</name>
</author>
<author><name sortKey="Nozadze, I" uniqKey="Nozadze I">I. Nozadze</name>
</author>
<author><name sortKey="Tsiklauri, N" uniqKey="Tsiklauri N">N. Tsiklauri</name>
</author>
<author><name sortKey="Gurtskaia, G" uniqKey="Gurtskaia G">G. Gurtskaia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ajayi, A A L" uniqKey="Ajayi A">A.A.L. Ajayi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morita, T" uniqKey="Morita T">T. Morita</name>
</author>
<author><name sortKey="Mcclain, S P" uniqKey="Mcclain S">S.P. McClain</name>
</author>
<author><name sortKey="Batia, L M" uniqKey="Batia L">L.M. Batia</name>
</author>
<author><name sortKey="Pellegrino, M" uniqKey="Pellegrino M">M. Pellegrino</name>
</author>
<author><name sortKey="Wilson, S R" uniqKey="Wilson S">S.R. Wilson</name>
</author>
<author><name sortKey="Kienzler, M A" uniqKey="Kienzler M">M.A. Kienzler</name>
</author>
<author><name sortKey="Lyman, K" uniqKey="Lyman K">K. Lyman</name>
</author>
<author><name sortKey="Olsen, A S B" uniqKey="Olsen A">A.S.B. Olsen</name>
</author>
<author><name sortKey="Wong, J F" uniqKey="Wong J">J.F. Wong</name>
</author>
<author><name sortKey="Stucky, C L" uniqKey="Stucky C">C.L. Stucky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, S R" uniqKey="Wilson S">S.R. Wilson</name>
</author>
<author><name sortKey="The, L" uniqKey="The L">L. Thé</name>
</author>
<author><name sortKey="Batia, L M" uniqKey="Batia L">L.M. Batia</name>
</author>
<author><name sortKey="Beattie, K" uniqKey="Beattie K">K. Beattie</name>
</author>
<author><name sortKey="Katibah, G E" uniqKey="Katibah G">G.E. Katibah</name>
</author>
<author><name sortKey="Mcclain, S P" uniqKey="Mcclain S">S.P. McClain</name>
</author>
<author><name sortKey="Pellegrino, M" uniqKey="Pellegrino M">M. Pellegrino</name>
</author>
<author><name sortKey="Estandian, D M" uniqKey="Estandian D">D.M. Estandian</name>
</author>
<author><name sortKey="Bautista, D M" uniqKey="Bautista D">D.M. Bautista</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cevikbas, F" uniqKey="Cevikbas F">F. Cevikbas</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Akiyama, T" uniqKey="Akiyama T">T. Akiyama</name>
</author>
<author><name sortKey="Kempkes, C" uniqKey="Kempkes C">C. Kempkes</name>
</author>
<author><name sortKey="Savinko, T" uniqKey="Savinko T">T. Savinko</name>
</author>
<author><name sortKey="Antal, A" uniqKey="Antal A">A. Antal</name>
</author>
<author><name sortKey="Kukova, G" uniqKey="Kukova G">G. Kukova</name>
</author>
<author><name sortKey="Buhl, T" uniqKey="Buhl T">T. Buhl</name>
</author>
<author><name sortKey="Ikoma, A" uniqKey="Ikoma A">A. Ikoma</name>
</author>
<author><name sortKey="Buddenkotte, J" uniqKey="Buddenkotte J">J. Buddenkotte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, L F" uniqKey="Cao L">L.-F. Cao</name>
</author>
<author><name sortKey="Si, M" uniqKey="Si M">M. Si</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name>
</author>
<author><name sortKey="Chen, L H" uniqKey="Chen L">L.-H. Chen</name>
</author>
<author><name sortKey="Peng, X Y" uniqKey="Peng X">X.-Y. Peng</name>
</author>
<author><name sortKey="Qin, Y Q" uniqKey="Qin Y">Y.-Q. Qin</name>
</author>
<author><name sortKey="Liu, T T" uniqKey="Liu T">T.-T. Liu</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name>
</author>
<author><name sortKey="Luo, W F" uniqKey="Luo W">W.-F. Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, L S" uniqKey="Wong L">L.S. Wong</name>
</author>
<author><name sortKey="Otsuka, A" uniqKey="Otsuka A">A. Otsuka</name>
</author>
<author><name sortKey="Yamamoto, Y" uniqKey="Yamamoto Y">Y. Yamamoto</name>
</author>
<author><name sortKey="Nonomura, Y" uniqKey="Nonomura Y">Y. Nonomura</name>
</author>
<author><name sortKey="Nakashima, C" uniqKey="Nakashima C">C. Nakashima</name>
</author>
<author><name sortKey="Kitayama, N" uniqKey="Kitayama N">N. Kitayama</name>
</author>
<author><name sortKey="Usui, K" uniqKey="Usui K">K. Usui</name>
</author>
<author><name sortKey="Honda, T" uniqKey="Honda T">T. Honda</name>
</author>
<author><name sortKey="Kabashima, K" uniqKey="Kabashima K">K. Kabashima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nozadze, I" uniqKey="Nozadze I">I. Nozadze</name>
</author>
<author><name sortKey="Tsiklauri, N" uniqKey="Tsiklauri N">N. Tsiklauri</name>
</author>
<author><name sortKey="Gurtskaia, G" uniqKey="Gurtskaia G">G. Gurtskaia</name>
</author>
<author><name sortKey="Tsagareli, M" uniqKey="Tsagareli M">M. Tsagareli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lieu, T" uniqKey="Lieu T">T. Lieu</name>
</author>
<author><name sortKey="Jayaweera, G" uniqKey="Jayaweera G">G. Jayaweera</name>
</author>
<author><name sortKey="Zhao, P" uniqKey="Zhao P">P. Zhao</name>
</author>
<author><name sortKey="Poole, D P" uniqKey="Poole D">D.P. Poole</name>
</author>
<author><name sortKey="Jensen, D" uniqKey="Jensen D">D. Jensen</name>
</author>
<author><name sortKey="Grace, M" uniqKey="Grace M">M. Grace</name>
</author>
<author><name sortKey="Mcintyre, P" uniqKey="Mcintyre P">P. McIntyre</name>
</author>
<author><name sortKey="Bron, R" uniqKey="Bron R">R. Bron</name>
</author>
<author><name sortKey="Wilson, Y M" uniqKey="Wilson Y">Y.M. Wilson</name>
</author>
<author><name sortKey="Krappitz, M" uniqKey="Krappitz M">M. Krappitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oh, M H" uniqKey="Oh M">M.-H. Oh</name>
</author>
<author><name sortKey="Oh, S Y" uniqKey="Oh S">S.Y. Oh</name>
</author>
<author><name sortKey="Lu, J" uniqKey="Lu J">J. Lu</name>
</author>
<author><name sortKey="Lou, H" uniqKey="Lou H">H. Lou</name>
</author>
<author><name sortKey="Myers, A C" uniqKey="Myers A">A.C. Myers</name>
</author>
<author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z. Zhu</name>
</author>
<author><name sortKey="Zheng, T" uniqKey="Zheng T">T. Zheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name>
</author>
<author><name sortKey="Escalera, J" uniqKey="Escalera J">J. Escalera</name>
</author>
<author><name sortKey="Balakrishna, S" uniqKey="Balakrishna S">S. Balakrishna</name>
</author>
<author><name sortKey="Fan, L" uniqKey="Fan L">L. Fan</name>
</author>
<author><name sortKey="Caceres, A I" uniqKey="Caceres A">A.I. Caceres</name>
</author>
<author><name sortKey="Robinson, E" uniqKey="Robinson E">E. Robinson</name>
</author>
<author><name sortKey="Sui, A" uniqKey="Sui A">A. Sui</name>
</author>
<author><name sortKey="Mckay, M C" uniqKey="Mckay M">M.C. McKay</name>
</author>
<author><name sortKey="Mcalexander, M A" uniqKey="Mcalexander M">M.A. McAlexander</name>
</author>
<author><name sortKey="Herrick, C A" uniqKey="Herrick C">C.A. Herrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mori, Y" uniqKey="Mori Y">Y. Mori</name>
</author>
<author><name sortKey="Takahashi, N" uniqKey="Takahashi N">N. Takahashi</name>
</author>
<author><name sortKey="Polat, O K" uniqKey="Polat O">O.K. Polat</name>
</author>
<author><name sortKey="Kurokawa, T" uniqKey="Kurokawa T">T. Kurokawa</name>
</author>
<author><name sortKey="Takeda, N" uniqKey="Takeda N">N. Takeda</name>
</author>
<author><name sortKey="Inoue, M" uniqKey="Inoue M">M. Inoue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bahia, P K" uniqKey="Bahia P">P.K. Bahia</name>
</author>
<author><name sortKey="Parks, T A" uniqKey="Parks T">T.A. Parks</name>
</author>
<author><name sortKey="Stanford, K R" uniqKey="Stanford K">K.R. Stanford</name>
</author>
<author><name sortKey="Mitchell, D A" uniqKey="Mitchell D">D.A. Mitchell</name>
</author>
<author><name sortKey="Varma, S" uniqKey="Varma S">S. Varma</name>
</author>
<author><name sortKey="Stevens, S M" uniqKey="Stevens S">S.M. Stevens</name>
</author>
<author><name sortKey="Taylor Clark, T E" uniqKey="Taylor Clark T">T.E. Taylor-Clark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De David Antoniazzi, C T" uniqKey="De David Antoniazzi C">C.T. de David Antoniazzi</name>
</author>
<author><name sortKey="De Pra, S D T" uniqKey="De Pra S">S.D.-T. De Prá</name>
</author>
<author><name sortKey="Ferro, P R" uniqKey="Ferro P">P.R. Ferro</name>
</author>
<author><name sortKey="Silva, M A" uniqKey="Silva M">M.A. Silva</name>
</author>
<author><name sortKey="Adamante, G" uniqKey="Adamante G">G. Adamante</name>
</author>
<author><name sortKey="De Almeida, A S" uniqKey="De Almeida A">A.S. de Almeida</name>
</author>
<author><name sortKey="Camponogara, C" uniqKey="Camponogara C">C. Camponogara</name>
</author>
<author><name sortKey="Da Silva, C R" uniqKey="Da Silva C">C.R. da Silva</name>
</author>
<author><name sortKey="De Bem Silveira, G" uniqKey="De Bem Silveira G">G. de Bem Silveira</name>
</author>
<author><name sortKey="Silveira, P C L" uniqKey="Silveira P">P.C.L. Silveira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nassini, R" uniqKey="Nassini R">R. Nassini</name>
</author>
<author><name sortKey="Pedretti, P" uniqKey="Pedretti P">P. Pedretti</name>
</author>
<author><name sortKey="Moretto, N" uniqKey="Moretto N">N. Moretto</name>
</author>
<author><name sortKey="Fusi, C" uniqKey="Fusi C">C. Fusi</name>
</author>
<author><name sortKey="Carnini, C" uniqKey="Carnini C">C. Carnini</name>
</author>
<author><name sortKey="Facchinetti, F" uniqKey="Facchinetti F">F. Facchinetti</name>
</author>
<author><name sortKey="Viscomi, A R" uniqKey="Viscomi A">A.R. Viscomi</name>
</author>
<author><name sortKey="Pisano, A R" uniqKey="Pisano A">A.R. Pisano</name>
</author>
<author><name sortKey="Stokesberry, S" uniqKey="Stokesberry S">S. Stokesberry</name>
</author>
<author><name sortKey="Brunmark, C" uniqKey="Brunmark C">C. Brunmark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Buch, T R H" uniqKey="Buch T">T.R.H. Büch</name>
</author>
<author><name sortKey="Sch Fer, E A M" uniqKey="Sch Fer E">E.A.M. Schäfer</name>
</author>
<author><name sortKey="Demmel, M T" uniqKey="Demmel M">M.-T. Demmel</name>
</author>
<author><name sortKey="Boekhoff, I" uniqKey="Boekhoff I">I. Boekhoff</name>
</author>
<author><name sortKey="Thiermann, H" uniqKey="Thiermann H">H. Thiermann</name>
</author>
<author><name sortKey="Gudermann, T" uniqKey="Gudermann T">T. Gudermann</name>
</author>
<author><name sortKey="Steinritz, D" uniqKey="Steinritz D">D. Steinritz</name>
</author>
<author><name sortKey="Schmidt, A" uniqKey="Schmidt A">A. Schmidt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andre, E" uniqKey="Andre E">E. Andrè</name>
</author>
<author><name sortKey="Gatti, R" uniqKey="Gatti R">R. Gatti</name>
</author>
<author><name sortKey="Trevisani, M" uniqKey="Trevisani M">M. Trevisani</name>
</author>
<author><name sortKey="Preti, D" uniqKey="Preti D">D. Preti</name>
</author>
<author><name sortKey="Baraldi, P G" uniqKey="Baraldi P">P.G. Baraldi</name>
</author>
<author><name sortKey="Patacchini, R" uniqKey="Patacchini R">R. Patacchini</name>
</author>
<author><name sortKey="Geppetti, P" uniqKey="Geppetti P">P. Geppetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Birrell, M A" uniqKey="Birrell M">M.A. Birrell</name>
</author>
<author><name sortKey="Belvisi, M G" uniqKey="Belvisi M">M.G. Belvisi</name>
</author>
<author><name sortKey="Grace, M" uniqKey="Grace M">M. Grace</name>
</author>
<author><name sortKey="Sadofsky, L" uniqKey="Sadofsky L">L. Sadofsky</name>
</author>
<author><name sortKey="Faruqi, S" uniqKey="Faruqi S">S. Faruqi</name>
</author>
<author><name sortKey="Hele, D J" uniqKey="Hele D">D.J. Hele</name>
</author>
<author><name sortKey="Maher, S A" uniqKey="Maher S">S.A. Maher</name>
</author>
<author><name sortKey="Freund Michel, V" uniqKey="Freund Michel V">V. Freund-Michel</name>
</author>
<author><name sortKey="Morice, A H" uniqKey="Morice A">A.H. Morice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taylor Clark, T E" uniqKey="Taylor Clark T">T.E. Taylor-Clark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wallace, H" uniqKey="Wallace H">H. Wallace</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caceres, A I" uniqKey="Caceres A">A.I. Caceres</name>
</author>
<author><name sortKey="Brackmann, M" uniqKey="Brackmann M">M. Brackmann</name>
</author>
<author><name sortKey="Elia, M D" uniqKey="Elia M">M.D. Elia</name>
</author>
<author><name sortKey="Bessac, B F" uniqKey="Bessac B">B.F. Bessac</name>
</author>
<author><name sortKey="Del Camino, D" uniqKey="Del Camino D">D. del Camino</name>
</author>
<author><name sortKey="D Mours, M" uniqKey="D Mours M">M. D’Amours</name>
</author>
<author><name sortKey="Witek, J S" uniqKey="Witek J">J.S. Witek</name>
</author>
<author><name sortKey="Fanger, C M" uniqKey="Fanger C">C.M. Fanger</name>
</author>
<author><name sortKey="Chong, J A" uniqKey="Chong J">J.A. Chong</name>
</author>
<author><name sortKey="Hayward, N J" uniqKey="Hayward N">N.J. Hayward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nassini, R" uniqKey="Nassini R">R. Nassini</name>
</author>
<author><name sortKey="Materazzi, S" uniqKey="Materazzi S">S. Materazzi</name>
</author>
<author><name sortKey="Andre, E" uniqKey="Andre E">E. Andrè</name>
</author>
<author><name sortKey="Sartiani, L" uniqKey="Sartiani L">L. Sartiani</name>
</author>
<author><name sortKey="Aldini, G" uniqKey="Aldini G">G. Aldini</name>
</author>
<author><name sortKey="Trevisani, M" uniqKey="Trevisani M">M. Trevisani</name>
</author>
<author><name sortKey="Carnini, C" uniqKey="Carnini C">C. Carnini</name>
</author>
<author><name sortKey="Massi, D" uniqKey="Massi D">D. Massi</name>
</author>
<author><name sortKey="Pedretti, P" uniqKey="Pedretti P">P. Pedretti</name>
</author>
<author><name sortKey="Carini, M" uniqKey="Carini M">M. Carini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gallo, V" uniqKey="Gallo V">V. Gallo</name>
</author>
<author><name sortKey="Dijk, F N" uniqKey="Dijk F">F.N. Dijk</name>
</author>
<author><name sortKey="Holloway, J W" uniqKey="Holloway J">J.W. Holloway</name>
</author>
<author><name sortKey="Ring, S M" uniqKey="Ring S">S.M. Ring</name>
</author>
<author><name sortKey="Koppelman, G H" uniqKey="Koppelman G">G.H. Koppelman</name>
</author>
<author><name sortKey="Postma, D S" uniqKey="Postma D">D.S. Postma</name>
</author>
<author><name sortKey="Strachan, D P" uniqKey="Strachan D">D.P. Strachan</name>
</author>
<author><name sortKey="Granell, R" uniqKey="Granell R">R. Granell</name>
</author>
<author><name sortKey="De Jongste, J C" uniqKey="De Jongste J">J.C. de Jongste</name>
</author>
<author><name sortKey="Jaddoe, V W V" uniqKey="Jaddoe V">V.W.V. Jaddoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grace, M" uniqKey="Grace M">M. Grace</name>
</author>
<author><name sortKey="Birrell, M A" uniqKey="Birrell M">M.A. Birrell</name>
</author>
<author><name sortKey="Dubuis, E" uniqKey="Dubuis E">E. Dubuis</name>
</author>
<author><name sortKey="Maher, S A" uniqKey="Maher S">S.A. Maher</name>
</author>
<author><name sortKey="Belvisi, M G" uniqKey="Belvisi M">M.G. Belvisi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andre, E" uniqKey="Andre E">E. Andrè</name>
</author>
<author><name sortKey="Campi, B" uniqKey="Campi B">B. Campi</name>
</author>
<author><name sortKey="Materazzi, S" uniqKey="Materazzi S">S. Materazzi</name>
</author>
<author><name sortKey="Trevisani, M" uniqKey="Trevisani M">M. Trevisani</name>
</author>
<author><name sortKey="Amadesi, S" uniqKey="Amadesi S">S. Amadesi</name>
</author>
<author><name sortKey="Massi, D" uniqKey="Massi D">D. Massi</name>
</author>
<author><name sortKey="Creminon, C" uniqKey="Creminon C">C. Creminon</name>
</author>
<author><name sortKey="Vaksman, N" uniqKey="Vaksman N">N. Vaksman</name>
</author>
<author><name sortKey="Nassini, R" uniqKey="Nassini R">R. Nassini</name>
</author>
<author><name sortKey="Civelli, M" uniqKey="Civelli M">M. Civelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheah, E Y" uniqKey="Cheah E">E.Y. Cheah</name>
</author>
<author><name sortKey="Burcham, P C" uniqKey="Burcham P">P.C. Burcham</name>
</author>
<author><name sortKey="Mann, T S" uniqKey="Mann T">T.S. Mann</name>
</author>
<author><name sortKey="Henry, P J" uniqKey="Henry P">P.J. Henry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shapiro, D" uniqKey="Shapiro D">D. Shapiro</name>
</author>
<author><name sortKey="Deering Rice, C E" uniqKey="Deering Rice C">C.E. Deering-Rice</name>
</author>
<author><name sortKey="Romero, E G" uniqKey="Romero E">E.G. Romero</name>
</author>
<author><name sortKey="Hughen, R W" uniqKey="Hughen R">R.W. Hughen</name>
</author>
<author><name sortKey="Light, A R" uniqKey="Light A">A.R. Light</name>
</author>
<author><name sortKey="Veranth, J M" uniqKey="Veranth J">J.M. Veranth</name>
</author>
<author><name sortKey="Reilly, C A" uniqKey="Reilly C">C.A. Reilly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mukhopadhyay, I" uniqKey="Mukhopadhyay I">I. Mukhopadhyay</name>
</author>
<author><name sortKey="Kulkarni, A" uniqKey="Kulkarni A">A. Kulkarni</name>
</author>
<author><name sortKey="Khairatkar Joshi, N" uniqKey="Khairatkar Joshi N">N. Khairatkar-Joshi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schaefer, E A M" uniqKey="Schaefer E">E.A.M. Schaefer</name>
</author>
<author><name sortKey="Stohr, S" uniqKey="Stohr S">S. Stohr</name>
</author>
<author><name sortKey="Meister, M" uniqKey="Meister M">M. Meister</name>
</author>
<author><name sortKey="Aigner, A" uniqKey="Aigner A">A. Aigner</name>
</author>
<author><name sortKey="Gudermann, T" uniqKey="Gudermann T">T. Gudermann</name>
</author>
<author><name sortKey="Buech, T R H" uniqKey="Buech T">T.R.H. Buech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takahashi, N" uniqKey="Takahashi N">N. Takahashi</name>
</author>
<author><name sortKey="Chen, H Y" uniqKey="Chen H">H.-Y. Chen</name>
</author>
<author><name sortKey="Harris, I S" uniqKey="Harris I">I.S. Harris</name>
</author>
<author><name sortKey="Stover, D G" uniqKey="Stover D">D.G. Stover</name>
</author>
<author><name sortKey="Selfors, L M" uniqKey="Selfors L">L.M. Selfors</name>
</author>
<author><name sortKey="Bronson, R T" uniqKey="Bronson R">R.T. Bronson</name>
</author>
<author><name sortKey="Deraedt, T" uniqKey="Deraedt T">T. Deraedt</name>
</author>
<author><name sortKey="Cichowski, K" uniqKey="Cichowski K">K. Cichowski</name>
</author>
<author><name sortKey="Welm, A L" uniqKey="Welm A">A.L. Welm</name>
</author>
<author><name sortKey="Mori, Y" uniqKey="Mori Y">Y. Mori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conklin, D J" uniqKey="Conklin D">D.J. Conklin</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name>
</author>
<author><name sortKey="Nystoriak, M A" uniqKey="Nystoriak M">M.A. Nystoriak</name>
</author>
<author><name sortKey="Jagatheesan, G" uniqKey="Jagatheesan G">G. Jagatheesan</name>
</author>
<author><name sortKey="Obal, D" uniqKey="Obal D">D. Obal</name>
</author>
<author><name sortKey="Kilfoil, P J" uniqKey="Kilfoil P">P.J. Kilfoil</name>
</author>
<author><name sortKey="Hoetker, J D" uniqKey="Hoetker J">J.D. Hoetker</name>
</author>
<author><name sortKey="Guo, L" uniqKey="Guo L">L. Guo</name>
</author>
<author><name sortKey="Bolli, R" uniqKey="Bolli R">R. Bolli</name>
</author>
<author><name sortKey="Bhatnagar, A" uniqKey="Bhatnagar A">A. Bhatnagar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamilton, N B" uniqKey="Hamilton N">N.B. Hamilton</name>
</author>
<author><name sortKey="Kolodziejczyk, K" uniqKey="Kolodziejczyk K">K. Kolodziejczyk</name>
</author>
<author><name sortKey="Kougioumtzidou, E" uniqKey="Kougioumtzidou E">E. Kougioumtzidou</name>
</author>
<author><name sortKey="Attwell, D" uniqKey="Attwell D">D. Attwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Earley, S" uniqKey="Earley S">S. Earley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pires, P W" uniqKey="Pires P">P.W. Pires</name>
</author>
<author><name sortKey="Earley, S" uniqKey="Earley S">S. Earley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuruvilla, M" uniqKey="Kuruvilla M">M. Kuruvilla</name>
</author>
<author><name sortKey="Kalangara, J" uniqKey="Kalangara J">J. Kalangara</name>
</author>
<author><name sortKey="Lee, F E H" uniqKey="Lee F">F.E.-H. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C C" uniqKey="Huang C">C.-C. Huang</name>
</author>
<author><name sortKey="Kim, Y S" uniqKey="Kim Y">Y.S. Kim</name>
</author>
<author><name sortKey="Olson, W P" uniqKey="Olson W">W.P. Olson</name>
</author>
<author><name sortKey="Li, F" uniqKey="Li F">F. Li</name>
</author>
<author><name sortKey="Guo, C" uniqKey="Guo C">C. Guo</name>
</author>
<author><name sortKey="Luo, W" uniqKey="Luo W">W. Luo</name>
</author>
<author><name sortKey="Huang, A J W" uniqKey="Huang A">A.J.W. Huang</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schmidt, M" uniqKey="Schmidt M">M. Schmidt</name>
</author>
<author><name sortKey="Dubin, A E" uniqKey="Dubin A">A.E. Dubin</name>
</author>
<author><name sortKey="Petrus, M J" uniqKey="Petrus M">M.J. Petrus</name>
</author>
<author><name sortKey="Earley, T J" uniqKey="Earley T">T.J. Earley</name>
</author>
<author><name sortKey="Patapoutian, A" uniqKey="Patapoutian A">A. Patapoutian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, D S" uniqKey="Cao D">D.-S. Cao</name>
</author>
<author><name sortKey="Zhong, L" uniqKey="Zhong L">L. Zhong</name>
</author>
<author><name sortKey="Hsieh, T H" uniqKey="Hsieh T">T.-H. Hsieh</name>
</author>
<author><name sortKey="Abooj, M" uniqKey="Abooj M">M. Abooj</name>
</author>
<author><name sortKey="Bishnoi, M" uniqKey="Bishnoi M">M. Bishnoi</name>
</author>
<author><name sortKey="Hughes, L" uniqKey="Hughes L">L. Hughes</name>
</author>
<author><name sortKey="Premkumar, L S" uniqKey="Premkumar L">L.S. Premkumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diaz Garcia, C M" uniqKey="Diaz Garcia C">C.M. Diaz-Garcia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Babes, A" uniqKey="Babes A">A. Babes</name>
</author>
<author><name sortKey="Fischer, M J M" uniqKey="Fischer M">M.J.M. Fischer</name>
</author>
<author><name sortKey="Filipovic, M" uniqKey="Filipovic M">M. Filipovic</name>
</author>
<author><name sortKey="Engel, M A" uniqKey="Engel M">M.A. Engel</name>
</author>
<author><name sortKey="Flonta, M L" uniqKey="Flonta M">M.-L. Flonta</name>
</author>
<author><name sortKey="Reeh, P W" uniqKey="Reeh P">P.W. Reeh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Camacho, S" uniqKey="Camacho S">S. Camacho</name>
</author>
<author><name sortKey="Michlig, S" uniqKey="Michlig S">S. Michlig</name>
</author>
<author><name sortKey="De Senarclens Bezencon, C" uniqKey="De Senarclens Bezencon C">C. de Senarclens-Bezençon</name>
</author>
<author><name sortKey="Meylan, J" uniqKey="Meylan J">J. Meylan</name>
</author>
<author><name sortKey="Meystre, J" uniqKey="Meystre J">J. Meystre</name>
</author>
<author><name sortKey="Pezzoli, M" uniqKey="Pezzoli M">M. Pezzoli</name>
</author>
<author><name sortKey="Markram, H" uniqKey="Markram H">H. Markram</name>
</author>
<author><name sortKey="Le Coutre, J" uniqKey="Le Coutre J">J. le Coutre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Allaman, I" uniqKey="Allaman I">I. Allaman</name>
</author>
<author><name sortKey="Belanger, M" uniqKey="Belanger M">M. Bélanger</name>
</author>
<author><name sortKey="Magistretti, P J" uniqKey="Magistretti P">P.J. Magistretti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kender, Z" uniqKey="Kender Z">Z. Kender</name>
</author>
<author><name sortKey="Fleming, T" uniqKey="Fleming T">T. Fleming</name>
</author>
<author><name sortKey="Kopf, S" uniqKey="Kopf S">S. Kopf</name>
</author>
<author><name sortKey="Torzsa, P" uniqKey="Torzsa P">P. Torzsa</name>
</author>
<author><name sortKey="Grolmusz, V" uniqKey="Grolmusz V">V. Grolmusz</name>
</author>
<author><name sortKey="Herzig, S" uniqKey="Herzig S">S. Herzig</name>
</author>
<author><name sortKey="Schleicher, E" uniqKey="Schleicher E">E. Schleicher</name>
</author>
<author><name sortKey="Racz, K" uniqKey="Racz K">K. Rácz</name>
</author>
<author><name sortKey="Reismann, P" uniqKey="Reismann P">P. Reismann</name>
</author>
<author><name sortKey="Nawroth, P P" uniqKey="Nawroth P">P.P. Nawroth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eberhardt, M J" uniqKey="Eberhardt M">M.J. Eberhardt</name>
</author>
<author><name sortKey="Filipovic, M R" uniqKey="Filipovic M">M.R. Filipovic</name>
</author>
<author><name sortKey="Leffler, A" uniqKey="Leffler A">A. Leffler</name>
</author>
<author><name sortKey="De La Roche, J" uniqKey="De La Roche J">J. de la Roche</name>
</author>
<author><name sortKey="Kistner, K" uniqKey="Kistner K">K. Kistner</name>
</author>
<author><name sortKey="Fischer, M J" uniqKey="Fischer M">M.J. Fischer</name>
</author>
<author><name sortKey="Fleming, T" uniqKey="Fleming T">T. Fleming</name>
</author>
<author><name sortKey="Zimmermann, K" uniqKey="Zimmermann K">K. Zimmermann</name>
</author>
<author><name sortKey="Ivanovic Burmazovic, I" uniqKey="Ivanovic Burmazovic I">I. Ivanovic-Burmazovic</name>
</author>
<author><name sortKey="Nawroth, P P" uniqKey="Nawroth P">P.P. Nawroth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Csek, K" uniqKey="Csek K">K. Csekő</name>
</author>
<author><name sortKey="Beckers, B" uniqKey="Beckers B">B. Beckers</name>
</author>
<author><name sortKey="Keszthelyi, D" uniqKey="Keszthelyi D">D. Keszthelyi</name>
</author>
<author><name sortKey="Helyes, Z" uniqKey="Helyes Z">Z. Helyes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Engel, M A" uniqKey="Engel M">M.A. Engel</name>
</author>
<author><name sortKey="Leffler, A" uniqKey="Leffler A">A. Leffler</name>
</author>
<author><name sortKey="Niedermirtl, F" uniqKey="Niedermirtl F">F. Niedermirtl</name>
</author>
<author><name sortKey="Babes, A" uniqKey="Babes A">A. Babes</name>
</author>
<author><name sortKey="Zimmermann, K" uniqKey="Zimmermann K">K. Zimmermann</name>
</author>
<author><name sortKey="Filipovi, M R" uniqKey="Filipovi M">M.R. Filipović</name>
</author>
<author><name sortKey="Izydorczyk, I" uniqKey="Izydorczyk I">I. Izydorczyk</name>
</author>
<author><name sortKey="Eberhardt, M" uniqKey="Eberhardt M">M. Eberhardt</name>
</author>
<author><name sortKey="Kichko, T I" uniqKey="Kichko T">T.I. Kichko</name>
</author>
<author><name sortKey="Mueller Tribbensee, S M" uniqKey="Mueller Tribbensee S">S.M. Mueller-Tribbensee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, K" uniqKey="Sun K">K. Sun</name>
</author>
<author><name sortKey="Lei, Y" uniqKey="Lei Y">Y. Lei</name>
</author>
<author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name>
</author>
<author><name sortKey="Wu, Z" uniqKey="Wu Z">Z. Wu</name>
</author>
<author><name sortKey="Wu, G" uniqKey="Wu G">G. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Avesaat, M" uniqKey="Van Avesaat M">M. van Avesaat</name>
</author>
<author><name sortKey="Troost, F J" uniqKey="Troost F">F.J. Troost</name>
</author>
<author><name sortKey="Westerterp Plantenga, M S" uniqKey="Westerterp Plantenga M">M.S. Westerterp-Plantenga</name>
</author>
<author><name sortKey="Helyes, Z" uniqKey="Helyes Z">Z. Helyes</name>
</author>
<author><name sortKey="Le Roux, C W" uniqKey="Le Roux C">C.W. Le Roux</name>
</author>
<author><name sortKey="Dekker, J" uniqKey="Dekker J">J. Dekker</name>
</author>
<author><name sortKey="Masclee, A A" uniqKey="Masclee A">A.A. Masclee</name>
</author>
<author><name sortKey="Keszthelyi, D" uniqKey="Keszthelyi D">D. Keszthelyi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwartz, E S" uniqKey="Schwartz E">E.S. Schwartz</name>
</author>
<author><name sortKey="La, J H" uniqKey="La J">J.-H. La</name>
</author>
<author><name sortKey="Scheff, N N" uniqKey="Scheff N">N.N. Scheff</name>
</author>
<author><name sortKey="Davis, B M" uniqKey="Davis B">B.M. Davis</name>
</author>
<author><name sortKey="Albers, K M" uniqKey="Albers K">K.M. Albers</name>
</author>
<author><name sortKey="Gebhart, G F" uniqKey="Gebhart G">G.F. Gebhart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nor Es, M M" uniqKey="Nor Es M">M.M. Norões</name>
</author>
<author><name sortKey="Santos, L G" uniqKey="Santos L">L.G. Santos</name>
</author>
<author><name sortKey="Gavioli, E C" uniqKey="Gavioli E">E.C. Gavioli</name>
</author>
<author><name sortKey="De Paula Soares Rachetti, V" uniqKey="De Paula Soares Rachetti V">V. de Paula Soares Rachetti</name>
</author>
<author><name sortKey="Otuki, M F" uniqKey="Otuki M">M.F. Otuki</name>
</author>
<author><name sortKey="De Almeida Cabrini, D" uniqKey="De Almeida Cabrini D">D. de Almeida Cabrini</name>
</author>
<author><name sortKey="Da Silveira Prudente, A" uniqKey="Da Silveira Prudente A">A. da Silveira Prudente</name>
</author>
<author><name sortKey="Oliveira, J R J M" uniqKey="Oliveira J">J.R.J.M. Oliveira</name>
</author>
<author><name sortKey="De Carvalho Goncalves, M" uniqKey="De Carvalho Goncalves M">M. de Carvalho Gonçalves</name>
</author>
<author><name sortKey="Ferreira, J" uniqKey="Ferreira J">J. Ferreira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kemeny, A" uniqKey="Kemeny A">Á. Kemény</name>
</author>
<author><name sortKey="Kodji, X" uniqKey="Kodji X">X. Kodji</name>
</author>
<author><name sortKey="Horvath, S" uniqKey="Horvath S">S. Horváth</name>
</author>
<author><name sortKey="Koml Di, R" uniqKey="Koml Di R">R. Komlódi</name>
</author>
<author><name sortKey="Sz Ke, E" uniqKey="Sz Ke E">É. Szőke</name>
</author>
<author><name sortKey="Sandor, Z" uniqKey="Sandor Z">Z. Sándor</name>
</author>
<author><name sortKey="Perkecz, A" uniqKey="Perkecz A">A. Perkecz</name>
</author>
<author><name sortKey="Gyomorei, C" uniqKey="Gyomorei C">C. Gyömörei</name>
</author>
<author><name sortKey="Setal, G" uniqKey="Setal G">G. Sétáló</name>
</author>
<author><name sortKey="Kelemen, B" uniqKey="Kelemen B">B. Kelemen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takaishi, M" uniqKey="Takaishi M">M. Takaishi</name>
</author>
<author><name sortKey="Uchida, K" uniqKey="Uchida K">K. Uchida</name>
</author>
<author><name sortKey="Fujita, F" uniqKey="Fujita F">F. Fujita</name>
</author>
<author><name sortKey="Tominaga, M" uniqKey="Tominaga M">M. Tominaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Cassia Da Silveira E Sa, R" uniqKey="De Cassia Da Silveira E Sa R">R. de Cássia da Silveira e Sá</name>
</author>
<author><name sortKey="Andrade, L N" uniqKey="Andrade L">L.N. Andrade</name>
</author>
<author><name sortKey="De Sousa, D P" uniqKey="De Sousa D">D.P. de Sousa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khan, A" uniqKey="Khan A">A. Khan</name>
</author>
<author><name sortKey="Safdar, M" uniqKey="Safdar M">M. Safdar</name>
</author>
<author><name sortKey="Ali Khan, M M" uniqKey="Ali Khan M">M.M. Ali Khan</name>
</author>
<author><name sortKey="Khattak, K N" uniqKey="Khattak K">K.N. Khattak</name>
</author>
<author><name sortKey="Anderson, R A" uniqKey="Anderson R">R.A. Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vanschoonbeek, K" uniqKey="Vanschoonbeek K">K. Vanschoonbeek</name>
</author>
<author><name sortKey="Thomassen, B J W" uniqKey="Thomassen B">B.J.W. Thomassen</name>
</author>
<author><name sortKey="Senden, J M" uniqKey="Senden J">J.M. Senden</name>
</author>
<author><name sortKey="Wodzig, W K W H" uniqKey="Wodzig W">W.K.W.H. Wodzig</name>
</author>
<author><name sortKey="Van Loon, L J C" uniqKey="Van Loon L">L.J.C. van Loon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khare, P" uniqKey="Khare P">P. Khare</name>
</author>
<author><name sortKey="Jagtap, S" uniqKey="Jagtap S">S. Jagtap</name>
</author>
<author><name sortKey="Jain, Y" uniqKey="Jain Y">Y. Jain</name>
</author>
<author><name sortKey="Baboota, R K" uniqKey="Baboota R">R.K. Baboota</name>
</author>
<author><name sortKey="Mangal, P" uniqKey="Mangal P">P. Mangal</name>
</author>
<author><name sortKey="Boparai, R K" uniqKey="Boparai R">R.K. Boparai</name>
</author>
<author><name sortKey="Bhutani, K K" uniqKey="Bhutani K">K.K. Bhutani</name>
</author>
<author><name sortKey="Sharma, S S" uniqKey="Sharma S">S.S. Sharma</name>
</author>
<author><name sortKey="Premkumar, L S" uniqKey="Premkumar L">L.S. Premkumar</name>
</author>
<author><name sortKey="Kondepudi, K K" uniqKey="Kondepudi K">K.K. Kondepudi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahn, J" uniqKey="Ahn J">J. Ahn</name>
</author>
<author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name>
</author>
<author><name sortKey="Im, S W" uniqKey="Im S">S.W. Im</name>
</author>
<author><name sortKey="Jung, C H" uniqKey="Jung C">C.H. Jung</name>
</author>
<author><name sortKey="Ha, T Y" uniqKey="Ha T">T.Y. Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zsombok, A" uniqKey="Zsombok A">A. Zsombok</name>
</author>
<author><name sortKey="Derbenev, A V" uniqKey="Derbenev A">A.V. Derbenev</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Sci (Basel)</journal-id>
<journal-id journal-id-type="iso-abbrev">Med Sci (Basel)</journal-id>
<journal-id journal-id-type="publisher-id">medsci</journal-id>
<journal-title-group><journal-title>Medical Sciences</journal-title>
</journal-title-group>
<issn pub-type="epub">2076-3271</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31547502</article-id>
<article-id pub-id-type="pmc">6836032</article-id>
<article-id pub-id-type="doi">10.3390/medsci7100099</article-id>
<article-id pub-id-type="publisher-id">medsci-07-00099</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Non-Analgesic Symptomatic or Disease—Modifying Potential of TRPA1</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3398-0442</contrib-id>
<name><surname>Heber</surname>
<given-names>Stefan</given-names>
</name>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3811-7066</contrib-id>
<name><surname>Fischer</surname>
<given-names>Michael J.M.</given-names>
</name>
<xref rid="c1-medsci-07-00099" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-medsci-07-00099">Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria;<email>stefan.heber@meduniwien.ac.at</email>
</aff>
<author-notes><corresp id="c1-medsci-07-00099"><label>*</label>
Correspondence: <email>michael.jm.fischer@meduniwien.ac.at</email>
; Tel.: +43-1-40160-31410</corresp>
</author-notes>
<pub-date pub-type="epub"><day>23</day>
<month>9</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><month>10</month>
<year>2019</year>
</pub-date>
<volume>7</volume>
<issue>10</issue>
<elocation-id>99</elocation-id>
<history><date date-type="received"><day>26</day>
<month>7</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>19</day>
<month>9</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 by the authors.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>TRPA1, a versatile ion channel of the Transient Receptor Potential (TRP) channel family, detects a large variety of chemicals and can contribute to signal processing of other stimuli, e.g., due to its sensitivity to cytosolic calcium elevation or phosphoinositolphosphate modulation. At first, TRPA1 was found on sensory neurons, where it can act as a sensor for potential or actual tissue damage that ultimately may elicit pain or itch as warning symptoms. This review provides an update regarding the analgesic and antipruritic potential of TRPA1 modulation and the respective clinical trials. Furthermore, TRPA1 has been found in an increasing amount of other cell types. Therefore, the main focus of the review is to discuss the non-analgesic and particularly the disease-modifying potential of TRPA1. This includes diseases of the respiratory system, cancer, ischemia, allergy, diabetes, and the gastrointestinal system. The involvement of TRPA1 in the respective pathophysiological cascades is so far mainly based on pre-clinical data.</p>
</abstract>
<kwd-group><kwd>therapy</kwd>
<kwd>pharmacology</kwd>
<kwd>pain</kwd>
<kwd>itch</kwd>
<kwd>drug development</kwd>
<kwd>ion channel</kwd>
<kwd>clinical study</kwd>
</kwd-group>
</article-meta>
</front>
<body><sec id="sec1-medsci-07-00099"><title>1. Overview</title>
<p>Since its cloning [<xref rid="B1-medsci-07-00099" ref-type="bibr">1</xref>
], description of its role in the sensory system [<xref rid="B2-medsci-07-00099" ref-type="bibr">2</xref>
], phenotyping of the knockout animals [<xref rid="B3-medsci-07-00099" ref-type="bibr">3</xref>
], and determination of the majority of the structure [<xref rid="B4-medsci-07-00099" ref-type="bibr">4</xref>
], Transient receptor potential cation channel subfamily A member 1 (TRPA1) has been the topic of several reviews. These were more general [<xref rid="B5-medsci-07-00099" ref-type="bibr">5</xref>
] or more topical, e.g., with a molecular perspective [<xref rid="B6-medsci-07-00099" ref-type="bibr">6</xref>
]. In addition, we refer to previous reviews dedicated to druggability [<xref rid="B7-medsci-07-00099" ref-type="bibr">7</xref>
], or focused on analgesic potential [<xref rid="B8-medsci-07-00099" ref-type="bibr">8</xref>
,<xref rid="B9-medsci-07-00099" ref-type="bibr">9</xref>
]. The present review considers targeting TRPA1 in clinical studies for a specific disease and lists evidence for TRPA1 as a potential therapeutic target in diseases not yet addressed in clinical studies, particularly considering non-analgesic potential. An important point is the therapeutic potential of pathways which involve TRPA1 downstream, e.g., due to its calcium- and Phosphatidylinositol-4,5-bisphosphat-dependence. Therefore, other upstream targets activating G<sub>s</sub>
or G<sub>q</sub>
-coupled G protein-coupled receptors might also have a secondary, so far potentially overlooked TRPA1 component in their pathophysiology [<xref rid="B7-medsci-07-00099" ref-type="bibr">7</xref>
]. Finally, the review discusses potential side effects of TRPA1 modulation, which could prevent, or at least largely limit, its therapeutic use.</p>
</sec>
<sec id="sec2-medsci-07-00099"><title>2. TRPA1-Related Substances</title>
<p>A large fraction of the major pharmaceutical players had or have development programs for TRPA1, and the compilation below represents only the visible tip of the iceberg. In 2007, HC–030031 developed by Hydra Biosciences was the first TRPA1 antagonist [<xref rid="B10-medsci-07-00099" ref-type="bibr">10</xref>
]. In the same year, Amgen published trichloro(sulfanyl)ethyl benzamides as potent TRPA1 antagonists, which were more than 10 times more potent in human compared to rat TRPA1 [<xref rid="B11-medsci-07-00099" ref-type="bibr">11</xref>
]. Species selectivity of TRPA1 could be at least partially attributed to amino acids of transmembrane domain 5 and the pore loop [<xref rid="B12-medsci-07-00099" ref-type="bibr">12</xref>
]. AP–18, reported in 2007 [<xref rid="B13-medsci-07-00099" ref-type="bibr">13</xref>
], has a similar potency to HC–030031. In 2009, Abbott disclosed the potent oxime derivative A–967079 (patent WO/2009/089082). The structure of A–967079 is similar to AP–18, but is more species-selective, providing a substantially improved IC50 of 67 nM on human TRPA1 (and 289 nM on rat TRPA1). Soon after becoming commercially available in 2012, A–967079 became the gold standard for experimental TRPA1 inhibition. In 2010, Glenmark Pharmaceuticals reported GRC17536, which has been pursued in clinical trials. Further substances which were advanced to phase I trials include CB–625 and ODM–108; for details, we refer to a recent review [<xref rid="B8-medsci-07-00099" ref-type="bibr">8</xref>
]. The latter three substances are currently not commercially available.</p>
<p>Finally, TRPA1 agonists should be mentioned, as the availability and specificity of the tools also affect the conclusions which can be drawn. The tools to activate TRPA1 have been rather poor for a long time, and substances with a limited range of specificity have been used at concentrations exceeding this range. Compared to e.g., allyl isothiocyanate (AITC), cinnamaldehyde, acrolein, or carvacrol, newer substances like JT010 and PF–4840154 allow potent and selective agonism [<xref rid="B14-medsci-07-00099" ref-type="bibr">14</xref>
,<xref rid="B15-medsci-07-00099" ref-type="bibr">15</xref>
]. TRPA1 activation reliably generates pain in humans, and models include AITC, cinnamaldehyde, carvacrol, and JT010 [<xref rid="B16-medsci-07-00099" ref-type="bibr">16</xref>
,<xref rid="B17-medsci-07-00099" ref-type="bibr">17</xref>
,<xref rid="B18-medsci-07-00099" ref-type="bibr">18</xref>
,<xref rid="B19-medsci-07-00099" ref-type="bibr">19</xref>
]. With a specific TRPA1 stimulation, sensations were not different from those generated by capsaicin, with the subjects reporting a primarily burning pain. Importantly, subjects stated that they did not experience cold sensations [<xref rid="B20-medsci-07-00099" ref-type="bibr">20</xref>
].</p>
<p>So far, no TRPA1 antagonists have been validated for therapeutic use, indicating unforeseen events in the development or limited efficacy in the chosen models, which has probably led to termination of TRPA1-focussed drug development by many pharmaceutical companies. However, the soaring output of TRPA1-related research provided an unexpectedly wide diversification of roles for TRPA1, and investigations for potential applications for pain and non-pain targets are underway. </p>
</sec>
<sec id="sec3-medsci-07-00099"><title>3. Symptomatic Therapy—Analgesic Potential</title>
<p>The potential of TRPA1-related drugs, primarily of TRPA1 antagonists, for the treatment of pain has been discussed in several reviews. Therefore, the aim of this paragraph is not to cover this extensively, but to provide an overview with reference to the respective literature.</p>
<p>It should be mentioned that TRPA1 expression in the nervous system dominated the literature before TRPA1 had stepwise been found in other tissues. The phenotype of TRPA1 knockout mice [<xref rid="B3-medsci-07-00099" ref-type="bibr">3</xref>
,<xref rid="B21-medsci-07-00099" ref-type="bibr">21</xref>
] showed mixed results regarding mechanical and cold sensitivity, but without doubt, a deficit for irritants and a role in inflammatory conditions. This explains an initial focus on pain, or at least disease processes where the aim of targeting TRPA1 was to control pain. The respective disease areas seem diverse when listed, and include postoperative pain, osteoarthritis, pain due to bacterial inflammation, gastrointestinal inflammatory pain, migraine, and also neuropathic pain, including diabetic neuropathy, peripheral traumatic neuropathy and chemotherapy-induced neuropathy [<xref rid="B8-medsci-07-00099" ref-type="bibr">8</xref>
]. However, this could also be viewed from a more pathophysiological perspective, considering conditions with oxidative stress and inflammatory sensitization, all of which activate or sensitize TRPA1, or lead to its overexpression.</p>
<p>The majority of the work is based on animal experiments. Clinical studies to treat pain with a TRPA1 antagonist are rather limited, which might be the result of a translational barrier. The larger genetic distance between humans and mice compared to other ion channels, e.g., TRPV1, might explain the pronounced species differences, which have been described for TRPA1 [<xref rid="B6-medsci-07-00099" ref-type="bibr">6</xref>
]. This applies not only to evolutionary distant but also to closer species, and has been used to identify molecular determinants as well as for drug development [<xref rid="B22-medsci-07-00099" ref-type="bibr">22</xref>
,<xref rid="B23-medsci-07-00099" ref-type="bibr">23</xref>
,<xref rid="B24-medsci-07-00099" ref-type="bibr">24</xref>
,<xref rid="B25-medsci-07-00099" ref-type="bibr">25</xref>
,<xref rid="B26-medsci-07-00099" ref-type="bibr">26</xref>
,<xref rid="B27-medsci-07-00099" ref-type="bibr">27</xref>
].</p>
<p><uri>ClinicalTrial.gov</uri>
lists 9 entries for TRPA1, of which three are completed. The pain-related trials are discussed here, and the non-pain related trials below. Glenmark Pharmaceuticals tested GRC17536 in a phase 2a clinical trial for diabetic neuropathy (NCT01726413, EudraCT Number 2012-002320-33). The study failed its primary endpoint 24-h average pain intensity. However, a post-hoc exploratory subgroup analysis suggested that GRC17536 might potentially be effective in “an irritable nociceptor subgroup” of patients, in which peripherally driven symptoms can be assumed (patent WO/2016/042501). This hypothesis, however, has never been tested.</p>
<p>In trial NCT02653703, menthol, which is an agonist at TRPM8 and human TRPA1 [<xref rid="B12-medsci-07-00099" ref-type="bibr">12</xref>
], could reduce trans-cinnamaldehyde-induced hyperalgesia and neurogenic inflammation [<xref rid="B18-medsci-07-00099" ref-type="bibr">18</xref>
]. A study regarding the involvement of TRPA1 in the relationship between cold exposure and chemotherapy-induced neuropathy has not been completed yet (NCT03329131), which also applies to a trial which investigates genetic variations in platinum-based chemotherapy-induced neuropathy (NCT03252834). Contribution of TRPA1 to heritable pain syndromes is investigated in NCT02696746 by correlating TRPA1 mutations with symptoms of pain in an observational study. A regulation of TRPA1 expression by intraoperative ketamine application is considered as a potential mechanism in NCT02729805. In addition, there are several drug candidates terminated in Phase 1, for which a favorable preclinical profile can be assumed, but there is obviously little incentive to share insights in a competitive market. This includes e.g., CB–625 by Cubist Pharmaceuticals or ODM–108 by Orion Pharma. Nevertheless, it has to be mentioned that, despite investigation for quite some years, there is astonishingly limited evidence from clinical pain trials for efficacy of TRPA1 inhibition.</p>
<p>Headaches can be differentiated into many subcategories, but many of these share the pathophysiology of pain and inflammation with other areas of the body. The majority of the migraine triggers can generate oxidative stress [<xref rid="B28-medsci-07-00099" ref-type="bibr">28</xref>
]. These triggers include various pathomechanisms, ranging from neuronal overactivation in an excitotoxic manner to downstream or direct targeting of mitochondrial function, or inhibition of scavenging pathways for cellular stress. A common denominator is the generation of reactive molecular species, an umbrella term to summarize many molecular entities, including reactive oxygen, nitrogen, and carbonyl species (ROS, RNS, RCS) and combinations thereof, but also endogenous lipid mediators. TRPA1 activation by these mediators can release further headache-provoking substances [<xref rid="B29-medsci-07-00099" ref-type="bibr">29</xref>
] and there is an epidemiological association between environmental exposure to TRPA1 activators and migraine [<xref rid="B30-medsci-07-00099" ref-type="bibr">30</xref>
,<xref rid="B31-medsci-07-00099" ref-type="bibr">31</xref>
]. Migraine-related involvement of TRPA1 has been addressed in a topical review [<xref rid="B32-medsci-07-00099" ref-type="bibr">32</xref>
].</p>
<p>In hindlimb ischemia as a model for peripheral arterial disease, spontaneous pain-related behaviour during reperfusion was reduced in TRPA1 knockouts and by TRPA1 inhibition [<xref rid="B33-medsci-07-00099" ref-type="bibr">33</xref>
]. TRPA1 inhibition might also help patients to cope with pathological response to cold challenge [<xref rid="B34-medsci-07-00099" ref-type="bibr">34</xref>
], which occurs e.g., in Raynaud syndrome patients. For both diseases with temporary insufficient perfusion, TRPA1 inhibition is assumed to be symptomatic, but not to alter the course of the disease.</p>
</sec>
<sec id="sec4-medsci-07-00099"><title>4. Symptomatic Therapy—Antipruritic Potential</title>
<p>Itch and pain are distinct sensations. However, the predominant view is that there are no neurons exclusively sensing pruritogens. Neuronal activation generates pain and itch with at least partially overlapping neuronal subpopulations [<xref rid="B35-medsci-07-00099" ref-type="bibr">35</xref>
,<xref rid="B36-medsci-07-00099" ref-type="bibr">36</xref>
,<xref rid="B37-medsci-07-00099" ref-type="bibr">37</xref>
]. There is ample evidence that TRPA1 contributes to itch. Acetone–ether–water mixture causes scratching, which is absent in TRPA1 knockouts [<xref rid="B38-medsci-07-00099" ref-type="bibr">38</xref>
]. TRPA1 is involved in neuronal excitation, causing itch by direct TRPA1 activation [<xref rid="B39-medsci-07-00099" ref-type="bibr">39</xref>
]. Similarly, the TLR7 agonist imiquimod can directly activate TRPA1, causing itch in mice [<xref rid="B40-medsci-07-00099" ref-type="bibr">40</xref>
], the latter being investigated in humans in trial NCT03943407. TRPA1 involvement can also occur downstream, particularly in models which have a defined receptor target associated with itch, e.g., using SLIGRL to activate MrgprC11 [<xref rid="B41-medsci-07-00099" ref-type="bibr">41</xref>
], chloroquine to activate Mrgpra3/X1 [<xref rid="B42-medsci-07-00099" ref-type="bibr">42</xref>
], serotonin to activate HTR7 [<xref rid="B43-medsci-07-00099" ref-type="bibr">43</xref>
], TSLP to activate the TSLP receptor [<xref rid="B44-medsci-07-00099" ref-type="bibr">44</xref>
], and IL31 to activate the IL31 receptor [<xref rid="B45-medsci-07-00099" ref-type="bibr">45</xref>
]. These diverse mediators converge on common pathways as modulating G protein-coupled receptors, and TRPA1 has been shown to be essential in these pathways [<xref rid="B46-medsci-07-00099" ref-type="bibr">46</xref>
,<xref rid="B47-medsci-07-00099" ref-type="bibr">47</xref>
,<xref rid="B48-medsci-07-00099" ref-type="bibr">48</xref>
,<xref rid="B49-medsci-07-00099" ref-type="bibr">49</xref>
].</p>
<p>Importantly, TRPA1 contributes to maintaining skin inflammation, and inhibition might therefore be disease-modifying, reducing skin swelling, leukocyte infiltration, and transepidermal water loss. [<xref rid="B38-medsci-07-00099" ref-type="bibr">38</xref>
,<xref rid="B50-medsci-07-00099" ref-type="bibr">50</xref>
,<xref rid="B51-medsci-07-00099" ref-type="bibr">51</xref>
]. Atopic dermatitis is a burdensome allergic disease with therapy-resistant chronic itch as a hallmark. In an oxazolone-based animal model of chronic dermatitis, TRPA1 inhibition could reduce scratching [<xref rid="B47-medsci-07-00099" ref-type="bibr">47</xref>
]. Scratching induced by IL-13 or IL-31 in atopic dermatitis models was reduced in TRPA1-deficient mice or by TRPA1 inhibition [<xref rid="B45-medsci-07-00099" ref-type="bibr">45</xref>
,<xref rid="B50-medsci-07-00099" ref-type="bibr">50</xref>
]. TRPA1 activation in mast cells might add to the disease, but the data do not allow to conclude that TRPA1 inhibition would be disease-modifying, which would qualify for the following chapter.</p>
</sec>
<sec id="sec5-medsci-07-00099"><title>5. Potential Disease—Modification through TRPA1 Modulation</title>
<p>The general role of TRPA1 in non-neuronal tissue is similar to the one in neuronal tissue: it senses reactive molecules [<xref rid="B52-medsci-07-00099" ref-type="bibr">52</xref>
,<xref rid="B53-medsci-07-00099" ref-type="bibr">53</xref>
]. Thus, there are two principal mechanisms by which TRPA1 activation or inhibition could modify diseases. First, TRPA1-expressing cells could be influenced directly. Alternatively, the sensory neurons supplying a tissue could modulate inflammatory processes by the release of neuropeptides, which might act directly on parenchymal cells or by means of chemoattraction or immunomodulation. Both mechanisms might be disease-modifying. Consequently, TRPA1 expression by non-neuronal cells of a tissue or organ should not be considered a prerequisite for the possibility of disease modification via TRPA1, as almost all tissues are innervated.</p>
<p>As example for disease modification might serve a disruption of the inflammatory cascade by prolonged TRPA1 inhibition using HC–030031, with reduced inflammation, shown by neutrophil immigration and oxidative stress [<xref rid="B54-medsci-07-00099" ref-type="bibr">54</xref>
].</p>
<sec id="sec5dot1-medsci-07-00099"><title>5.1. Respiratory Tract and Lung</title>
<p>In the respiratory tract, both supplying sensory neurons and non-neuronal cells express TRPA1, e.g., epithelial cells, smooth muscle cells, and invading immune cells [<xref rid="B55-medsci-07-00099" ref-type="bibr">55</xref>
,<xref rid="B56-medsci-07-00099" ref-type="bibr">56</xref>
]. Exposure to a TRPA1 agonist causes coughing in animals and humans [<xref rid="B57-medsci-07-00099" ref-type="bibr">57</xref>
,<xref rid="B58-medsci-07-00099" ref-type="bibr">58</xref>
,<xref rid="B59-medsci-07-00099" ref-type="bibr">59</xref>
]. Therefore, the normal function might be to protect the airways by evoking cough upon exposure to respiratory irritants. TRPA1 inhibition could be a symptomatic treatment for chronic cough, but on the other hand, might increase the uptake of harmful substances into the airways by reducing an important protective reflex. TRPA1 in the airways has also a major role in the generation of other nocifensive responses, such as mucus production, adjustment of bronchus diameter, and inflammation [<xref rid="B60-medsci-07-00099" ref-type="bibr">60</xref>
]. These responses are not pathological, but rather a physiological response to irritation. However, animal studies with genetic ablation or pharmacological inhibition of TRPA1 suggest that the channel is causally involved in airway inflammation under pathological conditions, such as asthma or chronic obstructive pulmonary disease [<xref rid="B55-medsci-07-00099" ref-type="bibr">55</xref>
,<xref rid="B61-medsci-07-00099" ref-type="bibr">61</xref>
,<xref rid="B62-medsci-07-00099" ref-type="bibr">62</xref>
]. The role of TRPA1 is also supported by single nucleotide polymorphisms in humans, which are associated with an increased risk for diagnosed asthma [<xref rid="B63-medsci-07-00099" ref-type="bibr">63</xref>
].</p>
<p>Furthermore, animal studies suggest that in the case of inflamed airways, TRPA1 might add insult to injury when endogenous inflammatory mediators prostaglandin E2 and bradykinin activate TRPA1 and further amplify the neurogenic contribution to inflammation [<xref rid="B64-medsci-07-00099" ref-type="bibr">64</xref>
]. Interestingly, both constriction and dilation of airways were reported in response to TRPA1 activation. While isolated guinea pig bronchi were found to constrict [<xref rid="B65-medsci-07-00099" ref-type="bibr">65</xref>
], isolated mouse tracheae were reported to dilate [<xref rid="B66-medsci-07-00099" ref-type="bibr">66</xref>
]. These opposing results might be due to different airway sections or the respective species.</p>
<p>Overall, bronchoconstriction and airway hyperreactivity could lead to more mucus retention and inflammation, and therefore might not only aggravate symptoms, but also progress the disease [<xref rid="B67-medsci-07-00099" ref-type="bibr">67</xref>
]. Also, an exaggerated inflammatory response might switch TRPA1 activation from protective to harmful, with all detrimental effects of chronic inflammation, including poorly reversible fibrosis and reduced lung compliance. Therapeutic potential for respiratory disorders has been addressed in a topical review [<xref rid="B68-medsci-07-00099" ref-type="bibr">68</xref>
].</p>
<p>Results from the registered human trials (NCT02591550, NCT02039999) on TRPA1 contribution to coughing have not been reported yet. A combined phase I/IIa study to evaluate inhaled GRC17536 in healthy volunteers and asthma patients has also been registered, but not been published (NHS, IRAS ID 110883). Considering substantial species differences, the role of TRPA1 in human airway inflammation remains unknown. Randomized controlled trials are required to establish whether TRPA1 might serve as a drug target to modify disease progression in humans.</p>
</sec>
<sec id="sec5dot2-medsci-07-00099"><title>5.2. Cancer</title>
<p>The role of TRP channels, particularly in lung cancer, has been discussed [<xref rid="B56-medsci-07-00099" ref-type="bibr">56</xref>
]. Small cell lung cancer cell lines were found to functionally express TRPA1 and activation of TRPA1 prevented apoptosis and led to increased cell survival [<xref rid="B69-medsci-07-00099" ref-type="bibr">69</xref>
], suggesting a potential role in tumour progression and a disease-modifying effect of chronic TRPA1 inhibition. Similarly, in breast cancer cells and spheroids, it was shown that TRPA1 sensing of cellular redox stress can activate anti-apoptotic programs. This led to increased oxidative stress tolerance, and TRPA1 inhibition could reduce tumour growth and enhance chemotherapy sensitivity in xenograft models [<xref rid="B70-medsci-07-00099" ref-type="bibr">70</xref>
]. TRPA1 expression has been shown to be highest in the mentioned tumour types, and it remains to be clarified whether the described mechanisms apply to other tumours.</p>
</sec>
<sec id="sec5dot3-medsci-07-00099"><title>5.3. Ischemia</title>
<p>Temporary ischemia in the heart or in the brain often has detrimental results for the subject. For these major disease entities, but also for peripheral artery disease, pre-clinical studies suggest the role of TRPA1.</p>
<p>In cardiac ischemia, the majority of damage occurs during reperfusion injury, when a high level of oxidative stress destroys cardiac tissue. Additional calcium, admitted through TRPA1 as a sensor for oxidative stress, might aggravate tissue injury [<xref rid="B71-medsci-07-00099" ref-type="bibr">71</xref>
]. In this study, TRPA1 deficient mice had smaller infarctions, with similar tissue at risk. Inhibition of TRPA1 also reduced damage in isolated cardiomyocytes. This suggests that TRPA1 might be involved in myocardial damage in response to ischemia, however, clinical studies have not been performed.</p>
<p>In the brain, TRPA1 is found on oligodendrocytes. Ischemia was found to cause demyelination, and the identified pathway includes acidosis, TRPA1 activation, and increased calcium load [<xref rid="B72-medsci-07-00099" ref-type="bibr">72</xref>
]. Ischemic damage was less pronounced in TRPA1 knockouts and could be inhibited by several TRPA1 antagonists. However, also neuroprotective effects of TRPA1 in cerebral ischemia need to be considered. TRPA1 expressed by endothelial cells of rodent cerebral and cerebellar pial arteries can induce cerebral artery dilation [<xref rid="B73-medsci-07-00099" ref-type="bibr">73</xref>
]. In a model of ischemic stroke, endothelial cell specific TRPA1-knockout animals exhibited larger infarct sizes, supporting the view that TRPA1 activation by endogenous agonists generated during ischemia can have protective effects as well [<xref rid="B74-medsci-07-00099" ref-type="bibr">74</xref>
]. Thus, TRPA1 activation in human ischemia might turn out to be a two-edged sword, where both favourable and unfavourable effects result from TRPA1 modulation. Before clinical trials can reasonably be performed, a more thorough understanding of TRPA1 contribution in cardiac physiology and pathophysiology needs to be established in pre-clinical studies. In summary, the net importance of TRPA1 is unclear, and might even depend on level, extent and duration of ischemia.</p>
</sec>
<sec id="sec5dot4-medsci-07-00099"><title>5.4. Allergic Conjunctivitis</title>
<p>Recently, it was suggested that TRPA1 might also be involved in allergic conjunctivitis [<xref rid="B75-medsci-07-00099" ref-type="bibr">75</xref>
]. Compared to wild-type animals, TRPA1 deficient mice show fewer symptoms in a model of allergic conjunctivitis [<xref rid="B76-medsci-07-00099" ref-type="bibr">76</xref>
]. The TRPA1 receptor levels at the cell surface were shown to be increased by nociceptive stimuli and inflammatory conditions [<xref rid="B77-medsci-07-00099" ref-type="bibr">77</xref>
]. Neuropeptide release in response to TRPA1 activation can stimulate other players in the inflammatory process, generating a vicious cycle which might be interrupted by TRPA1 inhibition. However, the principal causative agent is an antigen binding to IgE on mast cells, causing their degranulation. Therefore, it is unclear whether TRPA1 inhibition is sufficient to modify the disease.</p>
</sec>
<sec id="sec5dot5-medsci-07-00099"><title>5.5. Diabetes</title>
<p>TRPA1 was found to be expressed in rat pancreatic beta-cells, where it seems to act synergistically with K<sub>ATP</sub>
channels leading to insulin secretion [<xref rid="B78-medsci-07-00099" ref-type="bibr">78</xref>
]. This might imply that systemic TRPA1 agonists decrease blood glucose at first, but also contribute to beta-cell dysfunction in the long run based on beta-cell exhaustion [<xref rid="B79-medsci-07-00099" ref-type="bibr">79</xref>
]. What might also be relevant is that glibenclamide, an anti-diabetic drug that increases insulin secretion from beta-cells, activates TRPA1 [<xref rid="B80-medsci-07-00099" ref-type="bibr">80</xref>
]. However, the role of TRPA1 agonism in insulin secretion needs further validation. Cinnamaldehyde improves glucose tolerance, but without change in plasma insulin levels [<xref rid="B81-medsci-07-00099" ref-type="bibr">81</xref>
]. In analogy, a reduced oral glucose tolerance in presence of TRPA1 antagonism should be a major concern, but is not supported by observations in other laboratories (personal communication).</p>
<p>Considering disease progression, it is important to at least retard the sequelae of chronically increased blood glucose. Methylglyoxal, a metabolite that occurs as a side-product of glycolysis [<xref rid="B82-medsci-07-00099" ref-type="bibr">82</xref>
], is increased in diabetic populations [<xref rid="B83-medsci-07-00099" ref-type="bibr">83</xref>
]. This is thought to be detrimental to neuronal function and might contribute to positive symptoms via activation of TRPA1 [<xref rid="B84-medsci-07-00099" ref-type="bibr">84</xref>
] as well as to the negative symptoms due to the loss of nerve fibres. Concerning this, chronic inhibition of TRPA1 might be expected to reduce neuropathy in diabetes. However, effects of human short-term exposure should be explored before this hypothesis is addressed.</p>
</sec>
<sec id="sec5dot6-medsci-07-00099"><title>5.6. Gastrointestinal Tract and Skin</title>
<p>In inflammatory bowel disease, the evidence regarding TRPA1 involvement is far from unequivocal. TRPA1 expression seems to be altered in mucosal tissue, however, whether TRPA1 modulation exacerbates or ameliorates disease activity depends on the used animal model [<xref rid="B85-medsci-07-00099" ref-type="bibr">85</xref>
]. The neuropeptides Substance P and CGRP seem to be involved, which contribute to intestinal inflammation [<xref rid="B86-medsci-07-00099" ref-type="bibr">86</xref>
]. Reducing neuropeptide release by TRPA1 inhibition could reduce inflammation and support intestinal barrier integrity, which is likely to be disease-modifying. A reduction of intestinal permeability by oral cinnamaldehyde has been shown in porcine epithelial cells [<xref rid="B87-medsci-07-00099" ref-type="bibr">87</xref>
]. The only clinical study was performed in healthy volunteers and included cinnamaldehyde as a TRPA1 agonist and capsaicin as a TRPV1 agonist according to registration (NCT01667523). The primary endpoint was intestinal permeability as measured by plasma concentrations of GLP–1 and PYY, but in contrast to trial registration, only data regarding capsaicin were published [<xref rid="B88-medsci-07-00099" ref-type="bibr">88</xref>
]. Thus, the sample size calculation was not performed based on the provided primary outcome variable, which weakens the results. Taken together, a TRPA1-based modulation of inflammatory bowel disease could be therapeutic, but clinical trials are still missing. In experimental pancreatitis, early inhibition of TRPA1 reduced progression to chronic inflammation [<xref rid="B89-medsci-07-00099" ref-type="bibr">89</xref>
]. Regarding pharmacological exposure of a surface, the skin should also be considered. TRPA1 can facilitate [<xref rid="B51-medsci-07-00099" ref-type="bibr">51</xref>
,<xref rid="B90-medsci-07-00099" ref-type="bibr">90</xref>
] but also counteract skin inflammation [<xref rid="B91-medsci-07-00099" ref-type="bibr">91</xref>
], depending on the type and pathophysiology of the inflammation. Topical targeting of TRPA1 appears as an option. Systematic investigation of e.g., monoterpenoids, which have a high toxicity in many insects but a low toxicity in humans, has shown several TRPA1 inhibitors [<xref rid="B92-medsci-07-00099" ref-type="bibr">92</xref>
]. Within these, several have anti-inflammatory potential [<xref rid="B93-medsci-07-00099" ref-type="bibr">93</xref>
].</p>
</sec>
</sec>
<sec id="sec6-medsci-07-00099"><title>6. Adverse Effects</title>
<p>Currently, there are few undesired adverse effects known, and in particular, no class effects. While dietary supplementation with cinnamon left ambiguous results [<xref rid="B94-medsci-07-00099" ref-type="bibr">94</xref>
,<xref rid="B95-medsci-07-00099" ref-type="bibr">95</xref>
], administration of cinnamaldehyde or AITC was shown to prevent weight gain and hepatic steatosis caused by high fat diet [<xref rid="B96-medsci-07-00099" ref-type="bibr">96</xref>
,<xref rid="B97-medsci-07-00099" ref-type="bibr">97</xref>
]. Further improvements included regulation of anorexigenic markers, blood glucose and HbA1c levels, and insulin resistance. Such benefits of TRPA1 agonism might be considered as indirect evidence of the adverse effects of chronic TRPA1 antagonism [<xref rid="B98-medsci-07-00099" ref-type="bibr">98</xref>
]. However, it seems too speculative to draw any conclusion whether this could restrict or preclude TRPA1 antagonists from therapeutic use.</p>
</sec>
<sec id="sec7-medsci-07-00099"><title>7. Conclusions</title>
<p>After years of development by many companies, sufficiently developed substances can be assumed. The initial focus was on pain-related targets, and these remain promising. However, other diseases should also be considered. So far, these have only marginally been explored in clinical studies.</p>
</sec>
</body>
<back><ack><title>Acknowledgments</title>
<p>The author acknowledge comments and suggestions by Cosmin I. Ciotu.</p>
</ack>
<notes><title>Author Contributions</title>
<p>S.H. and M.J.M.F. did literature research and wrote the manuscript.</p>
</notes>
<notes><title>Funding</title>
<p>This work received no external funding.</p>
</notes>
<notes notes-type="COI-statement"><title>Conflicts of Interest</title>
<p>The authors declare no conflict of interest.</p>
</notes>
<ref-list><title>References</title>
<ref id="B1-medsci-07-00099"><label>1.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jaquemar</surname>
<given-names>D.</given-names>
</name>
<name><surname>Schenker</surname>
<given-names>T.</given-names>
</name>
<name><surname>Trueb</surname>
<given-names>B.</given-names>
</name>
</person-group>
<article-title>An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts</article-title>
<source>J. Biol. Chem.</source>
<year>1999</year>
<volume>274</volume>
<fpage>7325</fpage>
<lpage>7333</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.274.11.7325</pub-id>
<pub-id pub-id-type="pmid">10066796</pub-id>
</element-citation>
</ref>
<ref id="B2-medsci-07-00099"><label>2.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jordt</surname>
<given-names>S.-E.</given-names>
</name>
<name><surname>Bautista</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Chuang</surname>
<given-names>H.-H.</given-names>
</name>
<name><surname>McKemy</surname>
<given-names>D.D.</given-names>
</name>
<name><surname>Zygmunt</surname>
<given-names>P.M.</given-names>
</name>
<name><surname>Högestätt</surname>
<given-names>E.D.</given-names>
</name>
<name><surname>Meng</surname>
<given-names>I.D.</given-names>
</name>
<name><surname>Julius</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1</article-title>
<source>Nature</source>
<year>2004</year>
<volume>427</volume>
<fpage>260</fpage>
<lpage>265</lpage>
<pub-id pub-id-type="doi">10.1038/nature02282</pub-id>
<pub-id pub-id-type="pmid">14712238</pub-id>
</element-citation>
</ref>
<ref id="B3-medsci-07-00099"><label>3.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kwan</surname>
<given-names>K.Y.</given-names>
</name>
<name><surname>Allchorne</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Vollrath</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Christensen</surname>
<given-names>A.P.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>D.-S.</given-names>
</name>
<name><surname>Woolf</surname>
<given-names>C.J.</given-names>
</name>
<name><surname>Corey</surname>
<given-names>D.P.</given-names>
</name>
</person-group>
<article-title>TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction</article-title>
<source>Neuron</source>
<year>2006</year>
<volume>50</volume>
<fpage>277</fpage>
<lpage>289</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuron.2006.03.042</pub-id>
<pub-id pub-id-type="pmid">16630838</pub-id>
</element-citation>
</ref>
<ref id="B4-medsci-07-00099"><label>4.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paulsen</surname>
<given-names>C.E.</given-names>
</name>
<name><surname>Armache</surname>
<given-names>J.-P.</given-names>
</name>
<name><surname>Gao</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Cheng</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Julius</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Structure of the TRPA1 ion channel suggests regulatory mechanisms</article-title>
<source>Nature</source>
<year>2015</year>
<volume>520</volume>
<fpage>511</fpage>
<lpage>517</lpage>
<pub-id pub-id-type="doi">10.1038/nature14367</pub-id>
<pub-id pub-id-type="pmid">25855297</pub-id>
</element-citation>
</ref>
<ref id="B5-medsci-07-00099"><label>5.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Viana</surname>
<given-names>F.</given-names>
</name>
</person-group>
<article-title>TRPA1 channels: Molecular sentinels of cellular stress and tissue damage</article-title>
<source>J. Physiol. (Lond.)</source>
<year>2016</year>
<volume>594</volume>
<fpage>4151</fpage>
<lpage>4169</lpage>
<pub-id pub-id-type="doi">10.1113/JP270935</pub-id>
<pub-id pub-id-type="pmid">27079970</pub-id>
</element-citation>
</ref>
<ref id="B6-medsci-07-00099"><label>6.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meents</surname>
<given-names>J.E.</given-names>
</name>
<name><surname>Ciotu</surname>
<given-names>C.I.</given-names>
</name>
<name><surname>Fischer</surname>
<given-names>M.J.M.</given-names>
</name>
</person-group>
<article-title>TRPA1: A molecular view</article-title>
<source>J. Neurophysiol.</source>
<year>2019</year>
<volume>121</volume>
<fpage>427</fpage>
<lpage>443</lpage>
<pub-id pub-id-type="doi">10.1152/jn.00524.2018</pub-id>
<pub-id pub-id-type="pmid">30485151</pub-id>
</element-citation>
</ref>
<ref id="B7-medsci-07-00099"><label>7.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Hackos</surname>
<given-names>D.H.</given-names>
</name>
</person-group>
<article-title>TRPA1 as a drug target--promise and challenges</article-title>
<source>Naunyn Schmiedebergs Arch. Pharmacol.</source>
<year>2015</year>
<volume>388</volume>
<fpage>451</fpage>
<lpage>463</lpage>
<pub-id pub-id-type="doi">10.1007/s00210-015-1088-3</pub-id>
<pub-id pub-id-type="pmid">25640188</pub-id>
</element-citation>
</ref>
<ref id="B8-medsci-07-00099"><label>8.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Koivisto</surname>
<given-names>A.</given-names>
</name>
<name><surname>Jalava</surname>
<given-names>N.</given-names>
</name>
<name><surname>Bratty</surname>
<given-names>R.</given-names>
</name>
<name><surname>Pertovaara</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>TRPA1 Antagonists for Pain Relief</article-title>
<source>Pharmaceuticals (Basel)</source>
<year>2018</year>
<volume>11</volume>
<pub-id pub-id-type="doi">10.3390/ph11040117</pub-id>
</element-citation>
</ref>
<ref id="B9-medsci-07-00099"><label>9.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weyer-Menkhoff</surname>
<given-names>I.</given-names>
</name>
<name><surname>Lötsch</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Human pharmacological approaches to TRP-ion-channel-based analgesic drug development</article-title>
<source>Drug Discov. Today</source>
<year>2018</year>
<volume>23</volume>
<fpage>2003</fpage>
<lpage>2012</lpage>
<pub-id pub-id-type="doi">10.1016/j.drudis.2018.06.020</pub-id>
<pub-id pub-id-type="pmid">29969684</pub-id>
</element-citation>
</ref>
<ref id="B10-medsci-07-00099"><label>10.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>McNamara</surname>
<given-names>C.R.</given-names>
</name>
<name><surname>Mandel-Brehm</surname>
<given-names>J.</given-names>
</name>
<name><surname>Bautista</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Siemens</surname>
<given-names>J.</given-names>
</name>
<name><surname>Deranian</surname>
<given-names>K.L.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>M.</given-names>
</name>
<name><surname>Hayward</surname>
<given-names>N.J.</given-names>
</name>
<name><surname>Chong</surname>
<given-names>J.A.</given-names>
</name>
<name><surname>Julius</surname>
<given-names>D.</given-names>
</name>
<name><surname>Moran</surname>
<given-names>M.M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TRPA1 mediates formalin-induced pain</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2007</year>
<volume>104</volume>
<fpage>13525</fpage>
<lpage>13530</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0705924104</pub-id>
<pub-id pub-id-type="pmid">17686976</pub-id>
</element-citation>
</ref>
<ref id="B11-medsci-07-00099"><label>11.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Klionsky</surname>
<given-names>L.</given-names>
</name>
<name><surname>Tamir</surname>
<given-names>R.</given-names>
</name>
<name><surname>Gao</surname>
<given-names>B.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>W.</given-names>
</name>
<name><surname>Immke</surname>
<given-names>D.C.</given-names>
</name>
<name><surname>Nishimura</surname>
<given-names>N.</given-names>
</name>
<name><surname>Gavva</surname>
<given-names>N.R.</given-names>
</name>
</person-group>
<article-title>Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists</article-title>
<source>Mol. Pain</source>
<year>2007</year>
<volume>3</volume>
<fpage>39</fpage>
<pub-id pub-id-type="doi">10.1186/1744-8069-3-39</pub-id>
<pub-id pub-id-type="pmid">18086308</pub-id>
</element-citation>
</ref>
<ref id="B12-medsci-07-00099"><label>12.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xiao</surname>
<given-names>B.</given-names>
</name>
<name><surname>Dubin</surname>
<given-names>A.E.</given-names>
</name>
<name><surname>Bursulaya</surname>
<given-names>B.</given-names>
</name>
<name><surname>Viswanath</surname>
<given-names>V.</given-names>
</name>
<name><surname>Jegla</surname>
<given-names>T.J.</given-names>
</name>
<name><surname>Patapoutian</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels</article-title>
<source>J. Neurosci.</source>
<year>2008</year>
<volume>28</volume>
<fpage>9640</fpage>
<lpage>9651</lpage>
<pub-id pub-id-type="doi">10.1523/JNEUROSCI.2772-08.2008</pub-id>
<pub-id pub-id-type="pmid">18815250</pub-id>
</element-citation>
</ref>
<ref id="B13-medsci-07-00099"><label>13.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Petrus</surname>
<given-names>M.</given-names>
</name>
<name><surname>Peier</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Bandell</surname>
<given-names>M.</given-names>
</name>
<name><surname>Hwang</surname>
<given-names>S.W.</given-names>
</name>
<name><surname>Huynh</surname>
<given-names>T.</given-names>
</name>
<name><surname>Olney</surname>
<given-names>N.</given-names>
</name>
<name><surname>Jegla</surname>
<given-names>T.</given-names>
</name>
<name><surname>Patapoutian</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition</article-title>
<source>Mol. Pain</source>
<year>2007</year>
<volume>3</volume>
<fpage>40</fpage>
<pub-id pub-id-type="doi">10.1186/1744-8069-3-40</pub-id>
<pub-id pub-id-type="pmid">18086313</pub-id>
</element-citation>
</ref>
<ref id="B14-medsci-07-00099"><label>14.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ryckmans</surname>
<given-names>T.</given-names>
</name>
<name><surname>Aubdool</surname>
<given-names>A.A.</given-names>
</name>
<name><surname>Bodkin</surname>
<given-names>J.V.</given-names>
</name>
<name><surname>Cox</surname>
<given-names>P.</given-names>
</name>
<name><surname>Brain</surname>
<given-names>S.D.</given-names>
</name>
<name><surname>Dupont</surname>
<given-names>T.</given-names>
</name>
<name><surname>Fairman</surname>
<given-names>E.</given-names>
</name>
<name><surname>Hashizume</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Ishii</surname>
<given-names>N.</given-names>
</name>
<name><surname>Kato</surname>
<given-names>T.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel</article-title>
<source>Bioorg. Med. Chem. Lett.</source>
<year>2011</year>
<volume>21</volume>
<fpage>4857</fpage>
<lpage>4859</lpage>
<pub-id pub-id-type="doi">10.1016/j.bmcl.2011.06.035</pub-id>
<pub-id pub-id-type="pmid">21741838</pub-id>
</element-citation>
</ref>
<ref id="B15-medsci-07-00099"><label>15.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takaya</surname>
<given-names>J.</given-names>
</name>
<name><surname>Mio</surname>
<given-names>K.</given-names>
</name>
<name><surname>Shiraishi</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kurokawa</surname>
<given-names>T.</given-names>
</name>
<name><surname>Otsuka</surname>
<given-names>S.</given-names>
</name>
<name><surname>Mori</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Uesugi</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>A Potent and Site-Selective Agonist of TRPA1</article-title>
<source>J. Am. Chem. Soc.</source>
<year>2015</year>
<volume>137</volume>
<fpage>15859</fpage>
<lpage>15864</lpage>
<pub-id pub-id-type="doi">10.1021/jacs.5b10162</pub-id>
<pub-id pub-id-type="pmid">26630251</pub-id>
</element-citation>
</ref>
<ref id="B16-medsci-07-00099"><label>16.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Namer</surname>
<given-names>B.</given-names>
</name>
<name><surname>Seifert</surname>
<given-names>F.</given-names>
</name>
<name><surname>Handwerker</surname>
<given-names>H.O.</given-names>
</name>
<name><surname>Maihöfner</surname>
<given-names>C.</given-names>
</name>
</person-group>
<article-title>TRPA1 and TRPM8 activation in humans: Effects of cinnamaldehyde and menthol</article-title>
<source>Neuroreport</source>
<year>2005</year>
<volume>16</volume>
<fpage>955</fpage>
<lpage>959</lpage>
<pub-id pub-id-type="doi">10.1097/00001756-200506210-00015</pub-id>
<pub-id pub-id-type="pmid">15931068</pub-id>
</element-citation>
</ref>
<ref id="B17-medsci-07-00099"><label>17.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Klein</surname>
<given-names>A.H.</given-names>
</name>
<name><surname>Carstens</surname>
<given-names>M.I.</given-names>
</name>
<name><surname>Zanotto</surname>
<given-names>K.L.</given-names>
</name>
<name><surname>Sawyer</surname>
<given-names>C.M.</given-names>
</name>
<name><surname>Ivanov</surname>
<given-names>M.</given-names>
</name>
<name><surname>Cheung</surname>
<given-names>S.</given-names>
</name>
<name><surname>Carstens</surname>
<given-names>E.</given-names>
</name>
</person-group>
<article-title>Self- and cross-desensitization of oral irritation by menthol and cinnamaldehyde (CA) via peripheral interactions at trigeminal sensory neurons</article-title>
<source>Chem. Senses</source>
<year>2011</year>
<volume>36</volume>
<fpage>199</fpage>
<lpage>208</lpage>
<pub-id pub-id-type="doi">10.1093/chemse/bjq115</pub-id>
<pub-id pub-id-type="pmid">21059698</pub-id>
</element-citation>
</ref>
<ref id="B18-medsci-07-00099"><label>18.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Andersen</surname>
<given-names>H.H.</given-names>
</name>
<name><surname>Gazerani</surname>
<given-names>P.</given-names>
</name>
<name><surname>Arendt-Nielsen</surname>
<given-names>L.</given-names>
</name>
</person-group>
<article-title>High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde</article-title>
<source>J. Pain</source>
<year>2016</year>
<volume>17</volume>
<fpage>919</fpage>
<lpage>929</lpage>
<pub-id pub-id-type="doi">10.1016/j.jpain.2016.05.004</pub-id>
<pub-id pub-id-type="pmid">27260636</pub-id>
</element-citation>
</ref>
<ref id="B19-medsci-07-00099"><label>19.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname>
<given-names>M.G.</given-names>
</name>
<name><surname>Namer</surname>
<given-names>B.</given-names>
</name>
<name><surname>Reeh</surname>
<given-names>P.W.</given-names>
</name>
<name><surname>Fischer</surname>
<given-names>M.J.M.</given-names>
</name>
</person-group>
<article-title>TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain</article-title>
<source>J. Pain</source>
<year>2017</year>
<volume>18</volume>
<fpage>526</fpage>
<lpage>534</lpage>
<pub-id pub-id-type="doi">10.1016/j.jpain.2016.12.011</pub-id>
<pub-id pub-id-type="pmid">28062311</pub-id>
</element-citation>
</ref>
<ref id="B20-medsci-07-00099"><label>20.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heber</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gold-Binder</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ciotu</surname>
<given-names>C.I.</given-names>
</name>
<name><surname>Witek</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ninidze</surname>
<given-names>N.</given-names>
</name>
<name><surname>Kress</surname>
<given-names>H.-G.</given-names>
</name>
<name><surname>Fischer</surname>
<given-names>M.J.M.</given-names>
</name>
</person-group>
<article-title>A Human TRPA1-Specific Pain Model</article-title>
<source>J. Neurosci.</source>
<year>2019</year>
<volume>39</volume>
<fpage>3845</fpage>
<lpage>3855</lpage>
<pub-id pub-id-type="doi">10.1523/JNEUROSCI.3048-18.2019</pub-id>
<pub-id pub-id-type="pmid">30862667</pub-id>
</element-citation>
</ref>
<ref id="B21-medsci-07-00099"><label>21.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bautista</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Jordt</surname>
<given-names>S.-E.</given-names>
</name>
<name><surname>Nikai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Tsuruda</surname>
<given-names>P.R.</given-names>
</name>
<name><surname>Read</surname>
<given-names>A.J.</given-names>
</name>
<name><surname>Poblete</surname>
<given-names>J.</given-names>
</name>
<name><surname>Yamoah</surname>
<given-names>E.N.</given-names>
</name>
<name><surname>Basbaum</surname>
<given-names>A.I.</given-names>
</name>
<name><surname>Julius</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents</article-title>
<source>Cell</source>
<year>2006</year>
<volume>124</volume>
<fpage>1269</fpage>
<lpage>1282</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2006.02.023</pub-id>
<pub-id pub-id-type="pmid">16564016</pub-id>
</element-citation>
</ref>
<ref id="B22-medsci-07-00099"><label>22.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kang</surname>
<given-names>D.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lake</surname>
<given-names>M.</given-names>
</name>
<name><surname>Hogan</surname>
<given-names>J.O.</given-names>
</name>
<name><surname>Sun</surname>
<given-names>C.</given-names>
</name>
<name><surname>Walter</surname>
<given-names>K.</given-names>
</name>
<name><surname>Yao</surname>
<given-names>B.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Species differences and molecular determinant of TRPA1 cold sensitivity</article-title>
<source>Nat. Commun.</source>
<year>2013</year>
<volume>4</volume>
<fpage>2501</fpage>
<pub-id pub-id-type="doi">10.1038/ncomms3501</pub-id>
<pub-id pub-id-type="pmid">24071625</pub-id>
</element-citation>
</ref>
<ref id="B23-medsci-07-00099"><label>23.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de la Roche</surname>
<given-names>J.</given-names>
</name>
<name><surname>Eberhardt</surname>
<given-names>M.J.</given-names>
</name>
<name><surname>Klinger</surname>
<given-names>A.B.</given-names>
</name>
<name><surname>Stanslowsky</surname>
<given-names>N.</given-names>
</name>
<name><surname>Wegner</surname>
<given-names>F.</given-names>
</name>
<name><surname>Koppert</surname>
<given-names>W.</given-names>
</name>
<name><surname>Reeh</surname>
<given-names>P.W.</given-names>
</name>
<name><surname>Lampert</surname>
<given-names>A.</given-names>
</name>
<name><surname>Fischer</surname>
<given-names>M.J.M.</given-names>
</name>
<name><surname>Leffler</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6</article-title>
<source>J. Biol. Chem.</source>
<year>2013</year>
<volume>288</volume>
<fpage>20280</fpage>
<lpage>20292</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.M113.479337</pub-id>
<pub-id pub-id-type="pmid">23709225</pub-id>
</element-citation>
</ref>
<ref id="B24-medsci-07-00099"><label>24.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gracheva</surname>
<given-names>E.O.</given-names>
</name>
<name><surname>Ingolia</surname>
<given-names>N.T.</given-names>
</name>
<name><surname>Kelly</surname>
<given-names>Y.M.</given-names>
</name>
<name><surname>Cordero-Morales</surname>
<given-names>J.F.</given-names>
</name>
<name><surname>Hollopeter</surname>
<given-names>G.</given-names>
</name>
<name><surname>Chesler</surname>
<given-names>A.T.</given-names>
</name>
<name><surname>Sánchez</surname>
<given-names>E.E.</given-names>
</name>
<name><surname>Perez</surname>
<given-names>J.C.</given-names>
</name>
<name><surname>Weissman</surname>
<given-names>J.S.</given-names>
</name>
<name><surname>Julius</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Molecular basis of infrared detection by snakes</article-title>
<source>Nature</source>
<year>2010</year>
<volume>464</volume>
<fpage>1006</fpage>
<lpage>1011</lpage>
<pub-id pub-id-type="doi">10.1038/nature08943</pub-id>
<pub-id pub-id-type="pmid">20228791</pub-id>
</element-citation>
</ref>
<ref id="B25-medsci-07-00099"><label>25.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nakatsuka</surname>
<given-names>K.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>R.</given-names>
</name>
<name><surname>Saito</surname>
<given-names>S.</given-names>
</name>
<name><surname>Banzawa</surname>
<given-names>N.</given-names>
</name>
<name><surname>Takahashi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Tominaga</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ohta</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences</article-title>
<source>J. Mol. Neurosci.</source>
<year>2013</year>
<volume>51</volume>
<fpage>754</fpage>
<lpage>762</lpage>
<pub-id pub-id-type="doi">10.1007/s12031-013-0060-2</pub-id>
<pub-id pub-id-type="pmid">23872983</pub-id>
</element-citation>
</ref>
<ref id="B26-medsci-07-00099"><label>26.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saito</surname>
<given-names>S.</given-names>
</name>
<name><surname>Tominaga</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates</article-title>
<source>Temperature (Austin)</source>
<year>2017</year>
<volume>4</volume>
<fpage>141</fpage>
<lpage>152</lpage>
<pub-id pub-id-type="doi">10.1080/23328940.2017.1315478</pub-id>
<pub-id pub-id-type="pmid">28680930</pub-id>
</element-citation>
</ref>
<ref id="B27-medsci-07-00099"><label>27.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bianchi</surname>
<given-names>B.R.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>X.-F.</given-names>
</name>
<name><surname>Reilly</surname>
<given-names>R.M.</given-names>
</name>
<name><surname>Kym</surname>
<given-names>P.R.</given-names>
</name>
<name><surname>Yao</surname>
<given-names>B.B.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels</article-title>
<source>J. Pharmacol. Exp. Ther.</source>
<year>2012</year>
<volume>341</volume>
<fpage>360</fpage>
<lpage>368</lpage>
<pub-id pub-id-type="doi">10.1124/jpet.111.189902</pub-id>
<pub-id pub-id-type="pmid">22319196</pub-id>
</element-citation>
</ref>
<ref id="B28-medsci-07-00099"><label>28.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Borkum</surname>
<given-names>J.M.</given-names>
</name>
</person-group>
<article-title>Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis</article-title>
<source>Headache</source>
<year>2016</year>
<volume>56</volume>
<fpage>12</fpage>
<lpage>35</lpage>
<pub-id pub-id-type="doi">10.1111/head.12725</pub-id>
<pub-id pub-id-type="pmid">26639834</pub-id>
</element-citation>
</ref>
<ref id="B29-medsci-07-00099"><label>29.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kunkler</surname>
<given-names>P.E.</given-names>
</name>
<name><surname>Ballard</surname>
<given-names>C.J.</given-names>
</name>
<name><surname>Oxford</surname>
<given-names>G.S.</given-names>
</name>
<name><surname>Hurley</surname>
<given-names>J.H.</given-names>
</name>
</person-group>
<article-title>TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation</article-title>
<source>Pain</source>
<year>2011</year>
<volume>152</volume>
<fpage>38</fpage>
<lpage>44</lpage>
<pub-id pub-id-type="doi">10.1016/j.pain.2010.08.021</pub-id>
<pub-id pub-id-type="pmid">21075522</pub-id>
</element-citation>
</ref>
<ref id="B30-medsci-07-00099"><label>30.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Anderson</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>Lau</surname>
<given-names>G.S.</given-names>
</name>
<name><surname>Taylor</surname>
<given-names>W.R.</given-names>
</name>
<name><surname>Critchley</surname>
<given-names>J.A.</given-names>
</name>
</person-group>
<article-title>Acute effects of the potent lacrimator o-chlorobenzylidene malononitrile (CS) tear gas</article-title>
<source>Hum. Exp. Toxicol.</source>
<year>1996</year>
<volume>15</volume>
<fpage>461</fpage>
<lpage>465</lpage>
<pub-id pub-id-type="doi">10.1177/096032719601500601</pub-id>
<pub-id pub-id-type="pmid">8793527</pub-id>
</element-citation>
</ref>
<ref id="B31-medsci-07-00099"><label>31.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lima</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Sapienza</surname>
<given-names>G.B.</given-names>
</name>
<name><surname>Giraud</surname>
<given-names>V.O.</given-names>
</name>
<name><surname>Fragoso</surname>
<given-names>Y.D.</given-names>
</name>
</person-group>
<article-title>Odors as triggering and worsening factors for migraine in men</article-title>
<source>Arq. de Neuro-Psiquiatr.</source>
<year>2011</year>
<volume>69</volume>
<fpage>324</fpage>
<lpage>327</lpage>
<pub-id pub-id-type="doi">10.1590/S0004-282X2011000300011</pub-id>
<pub-id pub-id-type="pmid">21625759</pub-id>
</element-citation>
</ref>
<ref id="B32-medsci-07-00099"><label>32.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benemei</surname>
<given-names>S.</given-names>
</name>
<name><surname>Fusi</surname>
<given-names>C.</given-names>
</name>
<name><surname>Trevisan</surname>
<given-names>G.</given-names>
</name>
<name><surname>Geppetti</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>The TRPA1 channel in migraine mechanism and treatment</article-title>
<source>Br. J. Pharmacol.</source>
<year>2014</year>
<volume>171</volume>
<fpage>2552</fpage>
<lpage>2567</lpage>
<pub-id pub-id-type="doi">10.1111/bph.12512</pub-id>
<pub-id pub-id-type="pmid">24206166</pub-id>
</element-citation>
</ref>
<ref id="B33-medsci-07-00099"><label>33.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>So</surname>
<given-names>K.</given-names>
</name>
<name><surname>Tei</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>M.</given-names>
</name>
<name><surname>Miyake</surname>
<given-names>T.</given-names>
</name>
<name><surname>Hiyama</surname>
<given-names>H.</given-names>
</name>
<name><surname>Shirakawa</surname>
<given-names>H.</given-names>
</name>
<name><surname>Imai</surname>
<given-names>S.</given-names>
</name>
<name><surname>Mori</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Nakagawa</surname>
<given-names>T.</given-names>
</name>
<name><surname>Matsubara</surname>
<given-names>K.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice</article-title>
<source>Sci. Rep.</source>
<year>2016</year>
<volume>6</volume>
<fpage>23261</fpage>
<pub-id pub-id-type="doi">10.1038/srep23261</pub-id>
<pub-id pub-id-type="pmid">26983498</pub-id>
</element-citation>
</ref>
<ref id="B34-medsci-07-00099"><label>34.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aubdool</surname>
<given-names>A.A.</given-names>
</name>
<name><surname>Graepel</surname>
<given-names>R.</given-names>
</name>
<name><surname>Kodji</surname>
<given-names>X.</given-names>
</name>
<name><surname>Alawi</surname>
<given-names>K.M.</given-names>
</name>
<name><surname>Bodkin</surname>
<given-names>J.V.</given-names>
</name>
<name><surname>Srivastava</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gentry</surname>
<given-names>C.</given-names>
</name>
<name><surname>Heads</surname>
<given-names>R.</given-names>
</name>
<name><surname>Grant</surname>
<given-names>A.D.</given-names>
</name>
<name><surname>Fernandes</surname>
<given-names>E.S.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TRPA1 is essential for the vascular response to environmental cold exposure</article-title>
<source>Nat. Commun.</source>
<year>2014</year>
<volume>5</volume>
<fpage>5732</fpage>
<pub-id pub-id-type="doi">10.1038/ncomms6732</pub-id>
<pub-id pub-id-type="pmid">25501034</pub-id>
</element-citation>
</ref>
<ref id="B35-medsci-07-00099"><label>35.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dong</surname>
<given-names>X.</given-names>
</name>
<name><surname>Dong</surname>
<given-names>X.</given-names>
</name>
</person-group>
<article-title>Peripheral and Central Mechanisms of Itch</article-title>
<source>Neuron</source>
<year>2018</year>
<volume>98</volume>
<fpage>482</fpage>
<lpage>494</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuron.2018.03.023</pub-id>
<pub-id pub-id-type="pmid">29723501</pub-id>
</element-citation>
</ref>
<ref id="B36-medsci-07-00099"><label>36.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xie</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Hu</surname>
<given-names>H.</given-names>
</name>
</person-group>
<article-title>TRP Channels as Drug Targets to Relieve Itch</article-title>
<source>Pharmaceuticals (Basel)</source>
<year>2018</year>
<volume>11</volume>
<pub-id pub-id-type="doi">10.3390/ph11040100</pub-id>
</element-citation>
</ref>
<ref id="B37-medsci-07-00099"><label>37.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moore</surname>
<given-names>C.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>R.</given-names>
</name>
<name><surname>Jordt</surname>
<given-names>S.-E.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Liedtke</surname>
<given-names>W.B.</given-names>
</name>
</person-group>
<article-title>Regulation of Pain and Itch by TRP Channels</article-title>
<source>Neurosci. Bull</source>
<year>2018</year>
<volume>34</volume>
<fpage>120</fpage>
<lpage>142</lpage>
<pub-id pub-id-type="doi">10.1007/s12264-017-0200-8</pub-id>
<pub-id pub-id-type="pmid">29282613</pub-id>
</element-citation>
</ref>
<ref id="B38-medsci-07-00099"><label>38.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wilson</surname>
<given-names>S.R.</given-names>
</name>
<name><surname>Nelson</surname>
<given-names>A.M.</given-names>
</name>
<name><surname>Batia</surname>
<given-names>L.</given-names>
</name>
<name><surname>Morita</surname>
<given-names>T.</given-names>
</name>
<name><surname>Estandian</surname>
<given-names>D.</given-names>
</name>
<name><surname>Owens</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Lumpkin</surname>
<given-names>E.A.</given-names>
</name>
<name><surname>Bautista</surname>
<given-names>D.M.</given-names>
</name>
</person-group>
<article-title>The ion channel TRPA1 is required for chronic itch</article-title>
<source>J. Neurosci.</source>
<year>2013</year>
<volume>33</volume>
<fpage>9283</fpage>
<lpage>9294</lpage>
<pub-id pub-id-type="doi">10.1523/JNEUROSCI.5318-12.2013</pub-id>
<pub-id pub-id-type="pmid">23719797</pub-id>
</element-citation>
</ref>
<ref id="B39-medsci-07-00099"><label>39.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Han</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>D.</given-names>
</name>
<name><surname>Convertino</surname>
<given-names>M.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>C.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>Y.H.</given-names>
</name>
<name><surname>Luo</surname>
<given-names>X.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>X.</given-names>
</name>
<name><surname>Nackley</surname>
<given-names>A.</given-names>
</name>
<name><surname>Dokholyan</surname>
<given-names>N.V.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus</article-title>
<source>Neuron</source>
<year>2018</year>
<volume>99</volume>
<fpage>449</fpage>
<lpage>463</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuron.2018.06.039</pub-id>
<pub-id pub-id-type="pmid">30033153</pub-id>
</element-citation>
</ref>
<ref id="B40-medsci-07-00099"><label>40.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Esancy</surname>
<given-names>K.</given-names>
</name>
<name><surname>Condon</surname>
<given-names>L.</given-names>
</name>
<name><surname>Feng</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kimball</surname>
<given-names>C.</given-names>
</name>
<name><surname>Curtright</surname>
<given-names>A.</given-names>
</name>
<name><surname>Dhaka</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>A zebrafish and mouse model for selective pruritus via direct activation of TRPA1</article-title>
<source>Elife</source>
<year>2018</year>
<volume>7</volume>
<pub-id pub-id-type="doi">10.7554/eLife.32036</pub-id>
</element-citation>
</ref>
<ref id="B41-medsci-07-00099"><label>41.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsagareli</surname>
<given-names>M.G.</given-names>
</name>
<name><surname>Nozadze</surname>
<given-names>I.</given-names>
</name>
<name><surname>Tsiklauri</surname>
<given-names>N.</given-names>
</name>
<name><surname>Gurtskaia</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice</article-title>
<source>Med. Sci. (Basel)</source>
<year>2019</year>
<volume>7</volume>
<pub-id pub-id-type="doi">10.3390/medsci7040062</pub-id>
<pub-id pub-id-type="pmid">31003539</pub-id>
</element-citation>
</ref>
<ref id="B42-medsci-07-00099"><label>42.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ajayi</surname>
<given-names>A.A.L.</given-names>
</name>
</person-group>
<article-title>Itching, chloroquine, and malaria: A review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non-histaminergic pruritus</article-title>
<source>Int. J. Dermatol.</source>
<year>2018</year>
<pub-id pub-id-type="doi">10.1111/ijd.14252</pub-id>
<pub-id pub-id-type="pmid">30362504</pub-id>
</element-citation>
</ref>
<ref id="B43-medsci-07-00099"><label>43.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morita</surname>
<given-names>T.</given-names>
</name>
<name><surname>McClain</surname>
<given-names>S.P.</given-names>
</name>
<name><surname>Batia</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Pellegrino</surname>
<given-names>M.</given-names>
</name>
<name><surname>Wilson</surname>
<given-names>S.R.</given-names>
</name>
<name><surname>Kienzler</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Lyman</surname>
<given-names>K.</given-names>
</name>
<name><surname>Olsen</surname>
<given-names>A.S.B.</given-names>
</name>
<name><surname>Wong</surname>
<given-names>J.F.</given-names>
</name>
<name><surname>Stucky</surname>
<given-names>C.L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>HTR7 Mediates Serotonergic Acute and Chronic Itch</article-title>
<source>Neuron</source>
<year>2015</year>
<volume>87</volume>
<fpage>124</fpage>
<lpage>138</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuron.2015.05.044</pub-id>
<pub-id pub-id-type="pmid">26074006</pub-id>
</element-citation>
</ref>
<ref id="B44-medsci-07-00099"><label>44.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wilson</surname>
<given-names>S.R.</given-names>
</name>
<name><surname>Thé</surname>
<given-names>L.</given-names>
</name>
<name><surname>Batia</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Beattie</surname>
<given-names>K.</given-names>
</name>
<name><surname>Katibah</surname>
<given-names>G.E.</given-names>
</name>
<name><surname>McClain</surname>
<given-names>S.P.</given-names>
</name>
<name><surname>Pellegrino</surname>
<given-names>M.</given-names>
</name>
<name><surname>Estandian</surname>
<given-names>D.M.</given-names>
</name>
<name><surname>Bautista</surname>
<given-names>D.M.</given-names>
</name>
</person-group>
<article-title>The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch</article-title>
<source>Cell</source>
<year>2013</year>
<volume>155</volume>
<fpage>285</fpage>
<lpage>295</lpage>
<pub-id pub-id-type="doi">10.1016/j.cell.2013.08.057</pub-id>
<pub-id pub-id-type="pmid">24094650</pub-id>
</element-citation>
</ref>
<ref id="B45-medsci-07-00099"><label>45.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cevikbas</surname>
<given-names>F.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>X.</given-names>
</name>
<name><surname>Akiyama</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kempkes</surname>
<given-names>C.</given-names>
</name>
<name><surname>Savinko</surname>
<given-names>T.</given-names>
</name>
<name><surname>Antal</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kukova</surname>
<given-names>G.</given-names>
</name>
<name><surname>Buhl</surname>
<given-names>T.</given-names>
</name>
<name><surname>Ikoma</surname>
<given-names>A.</given-names>
</name>
<name><surname>Buddenkotte</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1</article-title>
<source>J. Allergy Clin. Immunol.</source>
<year>2014</year>
<volume>133</volume>
<fpage>448</fpage>
<lpage>460</lpage>
<pub-id pub-id-type="doi">10.1016/j.jaci.2013.10.048</pub-id>
<pub-id pub-id-type="pmid">24373353</pub-id>
</element-citation>
</ref>
<ref id="B46-medsci-07-00099"><label>46.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cao</surname>
<given-names>L.-F.</given-names>
</name>
<name><surname>Si</surname>
<given-names>M.</given-names>
</name>
<name><surname>Huang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>L.-H.</given-names>
</name>
<name><surname>Peng</surname>
<given-names>X.-Y.</given-names>
</name>
<name><surname>Qin</surname>
<given-names>Y.-Q.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>T.-T.</given-names>
</name>
<name><surname>Zhou</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>T.</given-names>
</name>
<name><surname>Luo</surname>
<given-names>W.-F.</given-names>
</name>
</person-group>
<article-title>Long-term anti-itch effect of botulinum neurotoxin A is associated with downregulation of TRPV1 and TRPA1 in the dorsal root ganglia in mice</article-title>
<source>Neuroreport</source>
<year>2017</year>
<volume>28</volume>
<fpage>518</fpage>
<lpage>526</lpage>
<pub-id pub-id-type="doi">10.1097/WNR.0000000000000779</pub-id>
<pub-id pub-id-type="pmid">28410268</pub-id>
</element-citation>
</ref>
<ref id="B47-medsci-07-00099"><label>47.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wong</surname>
<given-names>L.S.</given-names>
</name>
<name><surname>Otsuka</surname>
<given-names>A.</given-names>
</name>
<name><surname>Yamamoto</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Nonomura</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Nakashima</surname>
<given-names>C.</given-names>
</name>
<name><surname>Kitayama</surname>
<given-names>N.</given-names>
</name>
<name><surname>Usui</surname>
<given-names>K.</given-names>
</name>
<name><surname>Honda</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kabashima</surname>
<given-names>K.</given-names>
</name>
</person-group>
<article-title>TRPA1 channel participates in tacrolimus-induced pruritus in a chronic contact hypersensitivity murine model</article-title>
<source>J. Dermatol. Sci.</source>
<year>2018</year>
<volume>89</volume>
<fpage>207</fpage>
<lpage>209</lpage>
<pub-id pub-id-type="doi">10.1016/j.jdermsci.2017.10.012</pub-id>
<pub-id pub-id-type="pmid">29128286</pub-id>
</element-citation>
</ref>
<ref id="B48-medsci-07-00099"><label>48.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nozadze</surname>
<given-names>I.</given-names>
</name>
<name><surname>Tsiklauri</surname>
<given-names>N.</given-names>
</name>
<name><surname>Gurtskaia</surname>
<given-names>G.</given-names>
</name>
<name><surname>Tsagareli</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>The Role of Transient Receptor Potential (Trpa1) Channel in Pruritus</article-title>
<source>Georgian Med. News</source>
<year>2018</year>
<fpage>134</fpage>
<lpage>137</lpage>
</element-citation>
</ref>
<ref id="B49-medsci-07-00099"><label>49.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lieu</surname>
<given-names>T.</given-names>
</name>
<name><surname>Jayaweera</surname>
<given-names>G.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>P.</given-names>
</name>
<name><surname>Poole</surname>
<given-names>D.P.</given-names>
</name>
<name><surname>Jensen</surname>
<given-names>D.</given-names>
</name>
<name><surname>Grace</surname>
<given-names>M.</given-names>
</name>
<name><surname>McIntyre</surname>
<given-names>P.</given-names>
</name>
<name><surname>Bron</surname>
<given-names>R.</given-names>
</name>
<name><surname>Wilson</surname>
<given-names>Y.M.</given-names>
</name>
<name><surname>Krappitz</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice</article-title>
<source>Gastroenterology</source>
<year>2014</year>
<volume>147</volume>
<fpage>1417</fpage>
<lpage>1428</lpage>
<pub-id pub-id-type="doi">10.1053/j.gastro.2014.08.042</pub-id>
<pub-id pub-id-type="pmid">25194674</pub-id>
</element-citation>
</ref>
<ref id="B50-medsci-07-00099"><label>50.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oh</surname>
<given-names>M.-H.</given-names>
</name>
<name><surname>Oh</surname>
<given-names>S.Y.</given-names>
</name>
<name><surname>Lu</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lou</surname>
<given-names>H.</given-names>
</name>
<name><surname>Myers</surname>
<given-names>A.C.</given-names>
</name>
<name><surname>Zhu</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Zheng</surname>
<given-names>T.</given-names>
</name>
</person-group>
<article-title>TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis</article-title>
<source>J. Immunol.</source>
<year>2013</year>
<volume>191</volume>
<fpage>5371</fpage>
<lpage>5382</lpage>
<pub-id pub-id-type="doi">10.4049/jimmunol.1300300</pub-id>
<pub-id pub-id-type="pmid">24140646</pub-id>
</element-citation>
</ref>
<ref id="B51-medsci-07-00099"><label>51.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>B.</given-names>
</name>
<name><surname>Escalera</surname>
<given-names>J.</given-names>
</name>
<name><surname>Balakrishna</surname>
<given-names>S.</given-names>
</name>
<name><surname>Fan</surname>
<given-names>L.</given-names>
</name>
<name><surname>Caceres</surname>
<given-names>A.I.</given-names>
</name>
<name><surname>Robinson</surname>
<given-names>E.</given-names>
</name>
<name><surname>Sui</surname>
<given-names>A.</given-names>
</name>
<name><surname>McKay</surname>
<given-names>M.C.</given-names>
</name>
<name><surname>McAlexander</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Herrick</surname>
<given-names>C.A.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis</article-title>
<source>FASEB J.</source>
<year>2013</year>
<volume>27</volume>
<fpage>3549</fpage>
<lpage>3563</lpage>
<pub-id pub-id-type="doi">10.1096/fj.13-229948</pub-id>
<pub-id pub-id-type="pmid">23722916</pub-id>
</element-citation>
</ref>
<ref id="B52-medsci-07-00099"><label>52.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mori</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Takahashi</surname>
<given-names>N.</given-names>
</name>
<name><surname>Polat</surname>
<given-names>O.K.</given-names>
</name>
<name><surname>Kurokawa</surname>
<given-names>T.</given-names>
</name>
<name><surname>Takeda</surname>
<given-names>N.</given-names>
</name>
<name><surname>Inoue</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation</article-title>
<source>Pflugers Arch.</source>
<year>2016</year>
<volume>468</volume>
<fpage>85</fpage>
<lpage>97</lpage>
<pub-id pub-id-type="doi">10.1007/s00424-015-1716-2</pub-id>
<pub-id pub-id-type="pmid">26149285</pub-id>
</element-citation>
</ref>
<ref id="B53-medsci-07-00099"><label>53.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bahia</surname>
<given-names>P.K.</given-names>
</name>
<name><surname>Parks</surname>
<given-names>T.A.</given-names>
</name>
<name><surname>Stanford</surname>
<given-names>K.R.</given-names>
</name>
<name><surname>Mitchell</surname>
<given-names>D.A.</given-names>
</name>
<name><surname>Varma</surname>
<given-names>S.</given-names>
</name>
<name><surname>Stevens</surname>
<given-names>S.M.</given-names>
</name>
<name><surname>Taylor-Clark</surname>
<given-names>T.E.</given-names>
</name>
</person-group>
<article-title>The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1</article-title>
<source>J. Gen. Physiol.</source>
<year>2016</year>
<volume>147</volume>
<fpage>451</fpage>
<lpage>465</lpage>
<pub-id pub-id-type="doi">10.1085/jgp.201611581</pub-id>
<pub-id pub-id-type="pmid">27241698</pub-id>
</element-citation>
</ref>
<ref id="B54-medsci-07-00099"><label>54.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de David Antoniazzi</surname>
<given-names>C.T.</given-names>
</name>
<name><surname>De Prá</surname>
<given-names>S.D.-T.</given-names>
</name>
<name><surname>Ferro</surname>
<given-names>P.R.</given-names>
</name>
<name><surname>Silva</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Adamante</surname>
<given-names>G.</given-names>
</name>
<name><surname>de Almeida</surname>
<given-names>A.S.</given-names>
</name>
<name><surname>Camponogara</surname>
<given-names>C.</given-names>
</name>
<name><surname>da Silva</surname>
<given-names>C.R.</given-names>
</name>
<name><surname>de Bem Silveira</surname>
<given-names>G.</given-names>
</name>
<name><surname>Silveira</surname>
<given-names>P.C.L.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Topical treatment with a transient receptor potential ankyrin 1 (TRPA1) antagonist reduced nociception and inflammation in a thermal lesion model in rats</article-title>
<source>Eur. J. Pharm. Sci.</source>
<year>2018</year>
<volume>125</volume>
<fpage>28</fpage>
<lpage>38</lpage>
<pub-id pub-id-type="doi">10.1016/j.ejps.2018.09.012</pub-id>
<pub-id pub-id-type="pmid">30236550</pub-id>
</element-citation>
</ref>
<ref id="B55-medsci-07-00099"><label>55.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nassini</surname>
<given-names>R.</given-names>
</name>
<name><surname>Pedretti</surname>
<given-names>P.</given-names>
</name>
<name><surname>Moretto</surname>
<given-names>N.</given-names>
</name>
<name><surname>Fusi</surname>
<given-names>C.</given-names>
</name>
<name><surname>Carnini</surname>
<given-names>C.</given-names>
</name>
<name><surname>Facchinetti</surname>
<given-names>F.</given-names>
</name>
<name><surname>Viscomi</surname>
<given-names>A.R.</given-names>
</name>
<name><surname>Pisano</surname>
<given-names>A.R.</given-names>
</name>
<name><surname>Stokesberry</surname>
<given-names>S.</given-names>
</name>
<name><surname>Brunmark</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation</article-title>
<source>PLoS ONE</source>
<year>2012</year>
<volume>7</volume>
<elocation-id>e42454</elocation-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0042454</pub-id>
<pub-id pub-id-type="pmid">22905134</pub-id>
</element-citation>
</ref>
<ref id="B56-medsci-07-00099"><label>56.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Büch</surname>
<given-names>T.R.H.</given-names>
</name>
<name><surname>Schäfer</surname>
<given-names>E.A.M.</given-names>
</name>
<name><surname>Demmel</surname>
<given-names>M.-T.</given-names>
</name>
<name><surname>Boekhoff</surname>
<given-names>I.</given-names>
</name>
<name><surname>Thiermann</surname>
<given-names>H.</given-names>
</name>
<name><surname>Gudermann</surname>
<given-names>T.</given-names>
</name>
<name><surname>Steinritz</surname>
<given-names>D.</given-names>
</name>
<name><surname>Schmidt</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells</article-title>
<source>Chem. Biol. Interact.</source>
<year>2013</year>
<volume>206</volume>
<fpage>462</fpage>
<lpage>471</lpage>
<pub-id pub-id-type="doi">10.1016/j.cbi.2013.08.012</pub-id>
<pub-id pub-id-type="pmid">23994502</pub-id>
</element-citation>
</ref>
<ref id="B57-medsci-07-00099"><label>57.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Andrè</surname>
<given-names>E.</given-names>
</name>
<name><surname>Gatti</surname>
<given-names>R.</given-names>
</name>
<name><surname>Trevisani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Preti</surname>
<given-names>D.</given-names>
</name>
<name><surname>Baraldi</surname>
<given-names>P.G.</given-names>
</name>
<name><surname>Patacchini</surname>
<given-names>R.</given-names>
</name>
<name><surname>Geppetti</surname>
<given-names>P.</given-names>
</name>
</person-group>
<article-title>Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents</article-title>
<source>Br. J. Pharmacol.</source>
<year>2009</year>
<volume>158</volume>
<fpage>1621</fpage>
<lpage>1628</lpage>
<pub-id pub-id-type="doi">10.1111/j.1476-5381.2009.00438.x</pub-id>
<pub-id pub-id-type="pmid">19845671</pub-id>
</element-citation>
</ref>
<ref id="B58-medsci-07-00099"><label>58.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Birrell</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Belvisi</surname>
<given-names>M.G.</given-names>
</name>
<name><surname>Grace</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sadofsky</surname>
<given-names>L.</given-names>
</name>
<name><surname>Faruqi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Hele</surname>
<given-names>D.J.</given-names>
</name>
<name><surname>Maher</surname>
<given-names>S.A.</given-names>
</name>
<name><surname>Freund-Michel</surname>
<given-names>V.</given-names>
</name>
<name><surname>Morice</surname>
<given-names>A.H.</given-names>
</name>
</person-group>
<article-title>TRPA1 agonists evoke coughing in guinea pig and human volunteers</article-title>
<source>Am. J. Respir. Crit. Care Med.</source>
<year>2009</year>
<volume>180</volume>
<fpage>1042</fpage>
<lpage>1047</lpage>
<pub-id pub-id-type="doi">10.1164/rccm.200905-0665OC</pub-id>
<pub-id pub-id-type="pmid">19729665</pub-id>
</element-citation>
</ref>
<ref id="B59-medsci-07-00099"><label>59.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Taylor-Clark</surname>
<given-names>T.E.</given-names>
</name>
</person-group>
<article-title>Role of reactive oxygen species and TRP channels in the cough reflex</article-title>
<source>Cell Calcium</source>
<year>2016</year>
<volume>60</volume>
<fpage>155</fpage>
<lpage>162</lpage>
<pub-id pub-id-type="doi">10.1016/j.ceca.2016.03.007</pub-id>
<pub-id pub-id-type="pmid">27016063</pub-id>
</element-citation>
</ref>
<ref id="B60-medsci-07-00099"><label>60.</label>
<element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Wallace</surname>
<given-names>H.</given-names>
</name>
</person-group>
<article-title>Airway Pathogenesis Is Linked to TRP Channels</article-title>
<source>Neurobiology of TRP Channels</source>
<person-group person-group-type="editor"><name><surname>Emir</surname>
<given-names>T.L.R.</given-names>
</name>
</person-group>
<comment>Frontiers in Neuroscience</comment>
<publisher-name>CRC Press/Taylor & Francis</publisher-name>
<publisher-loc>Boca Raton, FL, USA</publisher-loc>
<year>2017</year>
<isbn>978-1-315-15283-7</isbn>
</element-citation>
</ref>
<ref id="B61-medsci-07-00099"><label>61.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Caceres</surname>
<given-names>A.I.</given-names>
</name>
<name><surname>Brackmann</surname>
<given-names>M.</given-names>
</name>
<name><surname>Elia</surname>
<given-names>M.D.</given-names>
</name>
<name><surname>Bessac</surname>
<given-names>B.F.</given-names>
</name>
<name><surname>del Camino</surname>
<given-names>D.</given-names>
</name>
<name><surname>D’Amours</surname>
<given-names>M.</given-names>
</name>
<name><surname>Witek</surname>
<given-names>J.S.</given-names>
</name>
<name><surname>Fanger</surname>
<given-names>C.M.</given-names>
</name>
<name><surname>Chong</surname>
<given-names>J.A.</given-names>
</name>
<name><surname>Hayward</surname>
<given-names>N.J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma</article-title>
<source>Proc. Natl. Acad. Sci. USA</source>
<year>2009</year>
<volume>106</volume>
<fpage>9099</fpage>
<lpage>9104</lpage>
<pub-id pub-id-type="doi">10.1073/pnas.0900591106</pub-id>
<pub-id pub-id-type="pmid">19458046</pub-id>
</element-citation>
</ref>
<ref id="B62-medsci-07-00099"><label>62.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nassini</surname>
<given-names>R.</given-names>
</name>
<name><surname>Materazzi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Andrè</surname>
<given-names>E.</given-names>
</name>
<name><surname>Sartiani</surname>
<given-names>L.</given-names>
</name>
<name><surname>Aldini</surname>
<given-names>G.</given-names>
</name>
<name><surname>Trevisani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Carnini</surname>
<given-names>C.</given-names>
</name>
<name><surname>Massi</surname>
<given-names>D.</given-names>
</name>
<name><surname>Pedretti</surname>
<given-names>P.</given-names>
</name>
<name><surname>Carini</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents</article-title>
<source>FASEB J.</source>
<year>2010</year>
<volume>24</volume>
<fpage>4904</fpage>
<lpage>4916</lpage>
<pub-id pub-id-type="doi">10.1096/fj.10-162438</pub-id>
<pub-id pub-id-type="pmid">20720158</pub-id>
</element-citation>
</ref>
<ref id="B63-medsci-07-00099"><label>63.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gallo</surname>
<given-names>V.</given-names>
</name>
<name><surname>Dijk</surname>
<given-names>F.N.</given-names>
</name>
<name><surname>Holloway</surname>
<given-names>J.W.</given-names>
</name>
<name><surname>Ring</surname>
<given-names>S.M.</given-names>
</name>
<name><surname>Koppelman</surname>
<given-names>G.H.</given-names>
</name>
<name><surname>Postma</surname>
<given-names>D.S.</given-names>
</name>
<name><surname>Strachan</surname>
<given-names>D.P.</given-names>
</name>
<name><surname>Granell</surname>
<given-names>R.</given-names>
</name>
<name><surname>de Jongste</surname>
<given-names>J.C.</given-names>
</name>
<name><surname>Jaddoe</surname>
<given-names>V.W.V.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TRPA1 gene polymorphisms and childhood asthma</article-title>
<source>Pediatr. Allergy Immunol.</source>
<year>2017</year>
<volume>28</volume>
<fpage>191</fpage>
<lpage>198</lpage>
<pub-id pub-id-type="doi">10.1111/pai.12673</pub-id>
<pub-id pub-id-type="pmid">27779810</pub-id>
</element-citation>
</ref>
<ref id="B64-medsci-07-00099"><label>64.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grace</surname>
<given-names>M.</given-names>
</name>
<name><surname>Birrell</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Dubuis</surname>
<given-names>E.</given-names>
</name>
<name><surname>Maher</surname>
<given-names>S.A.</given-names>
</name>
<name><surname>Belvisi</surname>
<given-names>M.G.</given-names>
</name>
</person-group>
<article-title>Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin</article-title>
<source>Thorax</source>
<year>2012</year>
<volume>67</volume>
<fpage>891</fpage>
<lpage>900</lpage>
<pub-id pub-id-type="doi">10.1136/thoraxjnl-2011-201443</pub-id>
<pub-id pub-id-type="pmid">22693178</pub-id>
</element-citation>
</ref>
<ref id="B65-medsci-07-00099"><label>65.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Andrè</surname>
<given-names>E.</given-names>
</name>
<name><surname>Campi</surname>
<given-names>B.</given-names>
</name>
<name><surname>Materazzi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Trevisani</surname>
<given-names>M.</given-names>
</name>
<name><surname>Amadesi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Massi</surname>
<given-names>D.</given-names>
</name>
<name><surname>Creminon</surname>
<given-names>C.</given-names>
</name>
<name><surname>Vaksman</surname>
<given-names>N.</given-names>
</name>
<name><surname>Nassini</surname>
<given-names>R.</given-names>
</name>
<name><surname>Civelli</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents</article-title>
<source>J. Clin. Invest.</source>
<year>2008</year>
<volume>118</volume>
<fpage>2574</fpage>
<lpage>2582</lpage>
<pub-id pub-id-type="pmid">18568077</pub-id>
</element-citation>
</ref>
<ref id="B66-medsci-07-00099"><label>66.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheah</surname>
<given-names>E.Y.</given-names>
</name>
<name><surname>Burcham</surname>
<given-names>P.C.</given-names>
</name>
<name><surname>Mann</surname>
<given-names>T.S.</given-names>
</name>
<name><surname>Henry</surname>
<given-names>P.J.</given-names>
</name>
</person-group>
<article-title>Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism</article-title>
<source>Biochem. Pharmacol.</source>
<year>2014</year>
<volume>89</volume>
<fpage>148</fpage>
<lpage>156</lpage>
<pub-id pub-id-type="doi">10.1016/j.bcp.2014.02.009</pub-id>
<pub-id pub-id-type="pmid">24561178</pub-id>
</element-citation>
</ref>
<ref id="B67-medsci-07-00099"><label>67.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shapiro</surname>
<given-names>D.</given-names>
</name>
<name><surname>Deering-Rice</surname>
<given-names>C.E.</given-names>
</name>
<name><surname>Romero</surname>
<given-names>E.G.</given-names>
</name>
<name><surname>Hughen</surname>
<given-names>R.W.</given-names>
</name>
<name><surname>Light</surname>
<given-names>A.R.</given-names>
</name>
<name><surname>Veranth</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Reilly</surname>
<given-names>C.A.</given-names>
</name>
</person-group>
<article-title>Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material</article-title>
<source>Chem. Res. Toxicol.</source>
<year>2013</year>
<volume>26</volume>
<fpage>750</fpage>
<lpage>758</lpage>
<pub-id pub-id-type="doi">10.1021/tx400024h</pub-id>
<pub-id pub-id-type="pmid">23541125</pub-id>
</element-citation>
</ref>
<ref id="B68-medsci-07-00099"><label>68.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mukhopadhyay</surname>
<given-names>I.</given-names>
</name>
<name><surname>Kulkarni</surname>
<given-names>A.</given-names>
</name>
<name><surname>Khairatkar-Joshi</surname>
<given-names>N.</given-names>
</name>
</person-group>
<article-title>Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?</article-title>
<source>Pharmaceuticals (Basel)</source>
<year>2016</year>
<volume>9</volume>
<pub-id pub-id-type="doi">10.3390/ph9040070</pub-id>
</element-citation>
</ref>
<ref id="B69-medsci-07-00099"><label>69.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schaefer</surname>
<given-names>E.A.M.</given-names>
</name>
<name><surname>Stohr</surname>
<given-names>S.</given-names>
</name>
<name><surname>Meister</surname>
<given-names>M.</given-names>
</name>
<name><surname>Aigner</surname>
<given-names>A.</given-names>
</name>
<name><surname>Gudermann</surname>
<given-names>T.</given-names>
</name>
<name><surname>Buech</surname>
<given-names>T.R.H.</given-names>
</name>
</person-group>
<article-title>Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells</article-title>
<source>Biochem. Pharmacol.</source>
<year>2013</year>
<volume>85</volume>
<fpage>426</fpage>
<lpage>438</lpage>
<pub-id pub-id-type="doi">10.1016/j.bcp.2012.11.019</pub-id>
<pub-id pub-id-type="pmid">23219522</pub-id>
</element-citation>
</ref>
<ref id="B70-medsci-07-00099"><label>70.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takahashi</surname>
<given-names>N.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>H.-Y.</given-names>
</name>
<name><surname>Harris</surname>
<given-names>I.S.</given-names>
</name>
<name><surname>Stover</surname>
<given-names>D.G.</given-names>
</name>
<name><surname>Selfors</surname>
<given-names>L.M.</given-names>
</name>
<name><surname>Bronson</surname>
<given-names>R.T.</given-names>
</name>
<name><surname>Deraedt</surname>
<given-names>T.</given-names>
</name>
<name><surname>Cichowski</surname>
<given-names>K.</given-names>
</name>
<name><surname>Welm</surname>
<given-names>A.L.</given-names>
</name>
<name><surname>Mori</surname>
<given-names>Y.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance</article-title>
<source>Cancer Cell</source>
<year>2018</year>
<volume>33</volume>
<fpage>985</fpage>
<lpage>1003</lpage>
<pub-id pub-id-type="doi">10.1016/j.ccell.2018.05.001</pub-id>
<pub-id pub-id-type="pmid">29805077</pub-id>
</element-citation>
</ref>
<ref id="B71-medsci-07-00099"><label>71.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Conklin</surname>
<given-names>D.J.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Nystoriak</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Jagatheesan</surname>
<given-names>G.</given-names>
</name>
<name><surname>Obal</surname>
<given-names>D.</given-names>
</name>
<name><surname>Kilfoil</surname>
<given-names>P.J.</given-names>
</name>
<name><surname>Hoetker</surname>
<given-names>J.D.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>L.</given-names>
</name>
<name><surname>Bolli</surname>
<given-names>R.</given-names>
</name>
<name><surname>Bhatnagar</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>TRPA1 channel contributes to myocardial ischemia-reperfusion injury</article-title>
<source>Am. J. Physiol. Heart Circ. Physiol.</source>
<year>2019</year>
<volume>316</volume>
<fpage>H889</fpage>
<lpage>H899</lpage>
<pub-id pub-id-type="doi">10.1152/ajpheart.00106.2018</pub-id>
<pub-id pub-id-type="pmid">30735434</pub-id>
</element-citation>
</ref>
<ref id="B72-medsci-07-00099"><label>72.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hamilton</surname>
<given-names>N.B.</given-names>
</name>
<name><surname>Kolodziejczyk</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kougioumtzidou</surname>
<given-names>E.</given-names>
</name>
<name><surname>Attwell</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia</article-title>
<source>Nature</source>
<year>2016</year>
<volume>529</volume>
<fpage>523</fpage>
<lpage>527</lpage>
<pub-id pub-id-type="doi">10.1038/nature16519</pub-id>
<pub-id pub-id-type="pmid">26760212</pub-id>
</element-citation>
</ref>
<ref id="B73-medsci-07-00099"><label>73.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Earley</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>TRPA1 channels in the vasculature</article-title>
<source>Br. J. Pharmacol.</source>
<year>2012</year>
<volume>167</volume>
<fpage>13</fpage>
<lpage>22</lpage>
<pub-id pub-id-type="doi">10.1111/j.1476-5381.2012.02018.x</pub-id>
<pub-id pub-id-type="pmid">22563804</pub-id>
</element-citation>
</ref>
<ref id="B74-medsci-07-00099"><label>74.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pires</surname>
<given-names>P.W.</given-names>
</name>
<name><surname>Earley</surname>
<given-names>S.</given-names>
</name>
</person-group>
<article-title>Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke</article-title>
<source>Elife</source>
<year>2018</year>
<volume>7</volume>
<pub-id pub-id-type="doi">10.7554/eLife.35316</pub-id>
</element-citation>
</ref>
<ref id="B75-medsci-07-00099"><label>75.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuruvilla</surname>
<given-names>M.</given-names>
</name>
<name><surname>Kalangara</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>F.E.-H.</given-names>
</name>
</person-group>
<article-title>Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis</article-title>
<source>J. Investig. Allergol. Clin. Immunol.</source>
<year>2019</year>
<fpage>29</fpage>
<pub-id pub-id-type="doi">10.18176/jiaci.0320</pub-id>
</element-citation>
</ref>
<ref id="B76-medsci-07-00099"><label>76.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname>
<given-names>C.-C.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>Y.S.</given-names>
</name>
<name><surname>Olson</surname>
<given-names>W.P.</given-names>
</name>
<name><surname>Li</surname>
<given-names>F.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>C.</given-names>
</name>
<name><surname>Luo</surname>
<given-names>W.</given-names>
</name>
<name><surname>Huang</surname>
<given-names>A.J.W.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>Q.</given-names>
</name>
</person-group>
<article-title>A histamine-independent itch pathway is required for allergic ocular itch</article-title>
<source>J. Allergy Clin. Immunol.</source>
<year>2016</year>
<volume>137</volume>
<fpage>1267</fpage>
<lpage>1270</lpage>
<pub-id pub-id-type="doi">10.1016/j.jaci.2015.08.047</pub-id>
<pub-id pub-id-type="pmid">26521042</pub-id>
</element-citation>
</ref>
<ref id="B77-medsci-07-00099"><label>77.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schmidt</surname>
<given-names>M.</given-names>
</name>
<name><surname>Dubin</surname>
<given-names>A.E.</given-names>
</name>
<name><surname>Petrus</surname>
<given-names>M.J.</given-names>
</name>
<name><surname>Earley</surname>
<given-names>T.J.</given-names>
</name>
<name><surname>Patapoutian</surname>
<given-names>A.</given-names>
</name>
</person-group>
<article-title>Nociceptive signals induce trafficking of TRPA1 to the plasma membrane</article-title>
<source>Neuron</source>
<year>2009</year>
<volume>64</volume>
<fpage>498</fpage>
<lpage>509</lpage>
<pub-id pub-id-type="doi">10.1016/j.neuron.2009.09.030</pub-id>
<pub-id pub-id-type="pmid">19945392</pub-id>
</element-citation>
</ref>
<ref id="B78-medsci-07-00099"><label>78.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cao</surname>
<given-names>D.-S.</given-names>
</name>
<name><surname>Zhong</surname>
<given-names>L.</given-names>
</name>
<name><surname>Hsieh</surname>
<given-names>T.-H.</given-names>
</name>
<name><surname>Abooj</surname>
<given-names>M.</given-names>
</name>
<name><surname>Bishnoi</surname>
<given-names>M.</given-names>
</name>
<name><surname>Hughes</surname>
<given-names>L.</given-names>
</name>
<name><surname>Premkumar</surname>
<given-names>L.S.</given-names>
</name>
</person-group>
<article-title>Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells</article-title>
<source>PLoS ONE</source>
<year>2012</year>
<volume>7</volume>
<elocation-id>e38005</elocation-id>
<pub-id pub-id-type="doi">10.1371/journal.pone.0038005</pub-id>
<pub-id pub-id-type="pmid">22701540</pub-id>
</element-citation>
</ref>
<ref id="B79-medsci-07-00099"><label>79.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Diaz-Garcia</surname>
<given-names>C.M.</given-names>
</name>
</person-group>
<article-title>The TRPA1 channel and oral hypoglycemic agents: Is there complicity in β-cell exhaustion?</article-title>
<source>Channels (Austin)</source>
<year>2013</year>
<volume>7</volume>
<fpage>420</fpage>
<lpage>422</lpage>
<pub-id pub-id-type="doi">10.4161/chan.26024</pub-id>
<pub-id pub-id-type="pmid">23921548</pub-id>
</element-citation>
</ref>
<ref id="B80-medsci-07-00099"><label>80.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Babes</surname>
<given-names>A.</given-names>
</name>
<name><surname>Fischer</surname>
<given-names>M.J.M.</given-names>
</name>
<name><surname>Filipovic</surname>
<given-names>M.</given-names>
</name>
<name><surname>Engel</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Flonta</surname>
<given-names>M.-L.</given-names>
</name>
<name><surname>Reeh</surname>
<given-names>P.W.</given-names>
</name>
</person-group>
<article-title>The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel</article-title>
<source>Eur. J. Pharmacol.</source>
<year>2013</year>
<volume>704</volume>
<fpage>15</fpage>
<lpage>22</lpage>
<pub-id pub-id-type="doi">10.1016/j.ejphar.2013.02.018</pub-id>
<pub-id pub-id-type="pmid">23461853</pub-id>
</element-citation>
</ref>
<ref id="B81-medsci-07-00099"><label>81.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Camacho</surname>
<given-names>S.</given-names>
</name>
<name><surname>Michlig</surname>
<given-names>S.</given-names>
</name>
<name><surname>de Senarclens-Bezençon</surname>
<given-names>C.</given-names>
</name>
<name><surname>Meylan</surname>
<given-names>J.</given-names>
</name>
<name><surname>Meystre</surname>
<given-names>J.</given-names>
</name>
<name><surname>Pezzoli</surname>
<given-names>M.</given-names>
</name>
<name><surname>Markram</surname>
<given-names>H.</given-names>
</name>
<name><surname>le Coutre</surname>
<given-names>J.</given-names>
</name>
</person-group>
<article-title>Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying</article-title>
<source>Sci. Rep.</source>
<year>2015</year>
<volume>5</volume>
<fpage>7919</fpage>
<pub-id pub-id-type="doi">10.1038/srep07919</pub-id>
<pub-id pub-id-type="pmid">25605129</pub-id>
</element-citation>
</ref>
<ref id="B82-medsci-07-00099"><label>82.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Allaman</surname>
<given-names>I.</given-names>
</name>
<name><surname>Bélanger</surname>
<given-names>M.</given-names>
</name>
<name><surname>Magistretti</surname>
<given-names>P.J.</given-names>
</name>
</person-group>
<article-title>Methylglyoxal, the dark side of glycolysis</article-title>
<source>Front Neurosci.</source>
<year>2015</year>
<volume>9</volume>
<fpage>23</fpage>
<pub-id pub-id-type="doi">10.3389/fnins.2015.00023</pub-id>
<pub-id pub-id-type="pmid">25709564</pub-id>
</element-citation>
</ref>
<ref id="B83-medsci-07-00099"><label>83.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kender</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Fleming</surname>
<given-names>T.</given-names>
</name>
<name><surname>Kopf</surname>
<given-names>S.</given-names>
</name>
<name><surname>Torzsa</surname>
<given-names>P.</given-names>
</name>
<name><surname>Grolmusz</surname>
<given-names>V.</given-names>
</name>
<name><surname>Herzig</surname>
<given-names>S.</given-names>
</name>
<name><surname>Schleicher</surname>
<given-names>E.</given-names>
</name>
<name><surname>Rácz</surname>
<given-names>K.</given-names>
</name>
<name><surname>Reismann</surname>
<given-names>P.</given-names>
</name>
<name><surname>Nawroth</surname>
<given-names>P.P.</given-names>
</name>
</person-group>
<article-title>Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes</article-title>
<source>Exp. Clin. Endocrinol. Diabetes</source>
<year>2014</year>
<volume>122</volume>
<fpage>316</fpage>
<lpage>319</lpage>
<pub-id pub-id-type="doi">10.1055/s-0034-1371818</pub-id>
<pub-id pub-id-type="pmid">24710646</pub-id>
</element-citation>
</ref>
<ref id="B84-medsci-07-00099"><label>84.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eberhardt</surname>
<given-names>M.J.</given-names>
</name>
<name><surname>Filipovic</surname>
<given-names>M.R.</given-names>
</name>
<name><surname>Leffler</surname>
<given-names>A.</given-names>
</name>
<name><surname>de la Roche</surname>
<given-names>J.</given-names>
</name>
<name><surname>Kistner</surname>
<given-names>K.</given-names>
</name>
<name><surname>Fischer</surname>
<given-names>M.J.</given-names>
</name>
<name><surname>Fleming</surname>
<given-names>T.</given-names>
</name>
<name><surname>Zimmermann</surname>
<given-names>K.</given-names>
</name>
<name><surname>Ivanovic-Burmazovic</surname>
<given-names>I.</given-names>
</name>
<name><surname>Nawroth</surname>
<given-names>P.P.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): A possible mechanism of metabolic neuropathies</article-title>
<source>J. Biol. Chem.</source>
<year>2012</year>
<volume>287</volume>
<fpage>28291</fpage>
<lpage>28306</lpage>
<pub-id pub-id-type="doi">10.1074/jbc.M111.328674</pub-id>
<pub-id pub-id-type="pmid">22740698</pub-id>
</element-citation>
</ref>
<ref id="B85-medsci-07-00099"><label>85.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Csekő</surname>
<given-names>K.</given-names>
</name>
<name><surname>Beckers</surname>
<given-names>B.</given-names>
</name>
<name><surname>Keszthelyi</surname>
<given-names>D.</given-names>
</name>
<name><surname>Helyes</surname>
<given-names>Z.</given-names>
</name>
</person-group>
<article-title>Role of TRPV1 and TRPA1 Ion Channels in Inflammatory Bowel Diseases: Potential Therapeutic Targets?</article-title>
<source>Pharmaceuticals (Basel)</source>
<year>2019</year>
<volume>12</volume>
<pub-id pub-id-type="doi">10.3390/ph12020048</pub-id>
</element-citation>
</ref>
<ref id="B86-medsci-07-00099"><label>86.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Engel</surname>
<given-names>M.A.</given-names>
</name>
<name><surname>Leffler</surname>
<given-names>A.</given-names>
</name>
<name><surname>Niedermirtl</surname>
<given-names>F.</given-names>
</name>
<name><surname>Babes</surname>
<given-names>A.</given-names>
</name>
<name><surname>Zimmermann</surname>
<given-names>K.</given-names>
</name>
<name><surname>Filipović</surname>
<given-names>M.R.</given-names>
</name>
<name><surname>Izydorczyk</surname>
<given-names>I.</given-names>
</name>
<name><surname>Eberhardt</surname>
<given-names>M.</given-names>
</name>
<name><surname>Kichko</surname>
<given-names>T.I.</given-names>
</name>
<name><surname>Mueller-Tribbensee</surname>
<given-names>S.M.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TRPA1 and substance P mediate colitis in mice</article-title>
<source>Gastroenterology</source>
<year>2011</year>
<volume>141</volume>
<fpage>1346</fpage>
<lpage>1358</lpage>
<pub-id pub-id-type="doi">10.1053/j.gastro.2011.07.002</pub-id>
<pub-id pub-id-type="pmid">21763243</pub-id>
</element-citation>
</ref>
<ref id="B87-medsci-07-00099"><label>87.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sun</surname>
<given-names>K.</given-names>
</name>
<name><surname>Lei</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>R.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>G.</given-names>
</name>
</person-group>
<article-title>Cinnamicaldehyde regulates the expression of tight junction proteins and amino acid transporters in intestinal porcine epithelial cells</article-title>
<source>J. Anim. Sci. Biotechnol.</source>
<year>2017</year>
<volume>8</volume>
<fpage>66</fpage>
<pub-id pub-id-type="doi">10.1186/s40104-017-0186-0</pub-id>
<pub-id pub-id-type="pmid">28824802</pub-id>
</element-citation>
</ref>
<ref id="B88-medsci-07-00099"><label>88.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Avesaat</surname>
<given-names>M.</given-names>
</name>
<name><surname>Troost</surname>
<given-names>F.J.</given-names>
</name>
<name><surname>Westerterp-Plantenga</surname>
<given-names>M.S.</given-names>
</name>
<name><surname>Helyes</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Le Roux</surname>
<given-names>C.W.</given-names>
</name>
<name><surname>Dekker</surname>
<given-names>J.</given-names>
</name>
<name><surname>Masclee</surname>
<given-names>A.A.</given-names>
</name>
<name><surname>Keszthelyi</surname>
<given-names>D.</given-names>
</name>
</person-group>
<article-title>Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones</article-title>
<source>Am. J. Clin. Nutr.</source>
<year>2016</year>
<volume>103</volume>
<fpage>305</fpage>
<lpage>313</lpage>
<pub-id pub-id-type="doi">10.3945/ajcn.115.123414</pub-id>
<pub-id pub-id-type="pmid">26718419</pub-id>
</element-citation>
</ref>
<ref id="B89-medsci-07-00099"><label>89.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwartz</surname>
<given-names>E.S.</given-names>
</name>
<name><surname>La</surname>
<given-names>J.-H.</given-names>
</name>
<name><surname>Scheff</surname>
<given-names>N.N.</given-names>
</name>
<name><surname>Davis</surname>
<given-names>B.M.</given-names>
</name>
<name><surname>Albers</surname>
<given-names>K.M.</given-names>
</name>
<name><surname>Gebhart</surname>
<given-names>G.F.</given-names>
</name>
</person-group>
<article-title>TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis</article-title>
<source>J. Neurosci.</source>
<year>2013</year>
<volume>33</volume>
<fpage>5603</fpage>
<lpage>5611</lpage>
<pub-id pub-id-type="doi">10.1523/JNEUROSCI.1806-12.2013</pub-id>
<pub-id pub-id-type="pmid">23536075</pub-id>
</element-citation>
</ref>
<ref id="B90-medsci-07-00099"><label>90.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Norões</surname>
<given-names>M.M.</given-names>
</name>
<name><surname>Santos</surname>
<given-names>L.G.</given-names>
</name>
<name><surname>Gavioli</surname>
<given-names>E.C.</given-names>
</name>
<name><surname>de Paula Soares Rachetti</surname>
<given-names>V.</given-names>
</name>
<name><surname>Otuki</surname>
<given-names>M.F.</given-names>
</name>
<name><surname>de Almeida Cabrini</surname>
<given-names>D.</given-names>
</name>
<name><surname>da Silveira Prudente</surname>
<given-names>A.</given-names>
</name>
<name><surname>Oliveira</surname>
<given-names>J.R.J.M.</given-names>
</name>
<name><surname>de Carvalho Gonçalves</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ferreira</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice</article-title>
<source>Eur. J. Pharmacol.</source>
<year>2019</year>
<volume>858</volume>
<fpage>172460</fpage>
<pub-id pub-id-type="doi">10.1016/j.ejphar.2019.172460</pub-id>
<pub-id pub-id-type="pmid">31228448</pub-id>
</element-citation>
</ref>
<ref id="B91-medsci-07-00099"><label>91.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kemény</surname>
<given-names>Á.</given-names>
</name>
<name><surname>Kodji</surname>
<given-names>X.</given-names>
</name>
<name><surname>Horváth</surname>
<given-names>S.</given-names>
</name>
<name><surname>Komlódi</surname>
<given-names>R.</given-names>
</name>
<name><surname>Szőke</surname>
<given-names>É.</given-names>
</name>
<name><surname>Sándor</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Perkecz</surname>
<given-names>A.</given-names>
</name>
<name><surname>Gyömörei</surname>
<given-names>C.</given-names>
</name>
<name><surname>Sétáló</surname>
<given-names>G.</given-names>
</name>
<name><surname>Kelemen</surname>
<given-names>B.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice</article-title>
<source>J. Invest. Dermatol.</source>
<year>2018</year>
<volume>138</volume>
<fpage>1774</fpage>
<lpage>1784</lpage>
<pub-id pub-id-type="doi">10.1016/j.jid.2018.02.040</pub-id>
<pub-id pub-id-type="pmid">29550417</pub-id>
</element-citation>
</ref>
<ref id="B92-medsci-07-00099"><label>92.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takaishi</surname>
<given-names>M.</given-names>
</name>
<name><surname>Uchida</surname>
<given-names>K.</given-names>
</name>
<name><surname>Fujita</surname>
<given-names>F.</given-names>
</name>
<name><surname>Tominaga</surname>
<given-names>M.</given-names>
</name>
</person-group>
<article-title>Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity</article-title>
<source>J. Physiol. Sci.</source>
<year>2014</year>
<volume>64</volume>
<fpage>47</fpage>
<lpage>57</lpage>
<pub-id pub-id-type="doi">10.1007/s12576-013-0289-0</pub-id>
<pub-id pub-id-type="pmid">24122170</pub-id>
</element-citation>
</ref>
<ref id="B93-medsci-07-00099"><label>93.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Cássia da Silveira e Sá</surname>
<given-names>R.</given-names>
</name>
<name><surname>Andrade</surname>
<given-names>L.N.</given-names>
</name>
<name><surname>de Sousa</surname>
<given-names>D.P.</given-names>
</name>
</person-group>
<article-title>A review on anti-inflammatory activity of monoterpenes</article-title>
<source>Molecules</source>
<year>2013</year>
<volume>18</volume>
<fpage>1227</fpage>
<lpage>1254</lpage>
<pub-id pub-id-type="doi">10.3390/molecules18011227</pub-id>
<pub-id pub-id-type="pmid">23334570</pub-id>
</element-citation>
</ref>
<ref id="B94-medsci-07-00099"><label>94.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khan</surname>
<given-names>A.</given-names>
</name>
<name><surname>Safdar</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ali Khan</surname>
<given-names>M.M.</given-names>
</name>
<name><surname>Khattak</surname>
<given-names>K.N.</given-names>
</name>
<name><surname>Anderson</surname>
<given-names>R.A.</given-names>
</name>
</person-group>
<article-title>Cinnamon improves glucose and lipids of people with type 2 diabetes</article-title>
<source>Diabetes Care</source>
<year>2003</year>
<volume>26</volume>
<fpage>3215</fpage>
<lpage>3218</lpage>
<pub-id pub-id-type="doi">10.2337/diacare.26.12.3215</pub-id>
<pub-id pub-id-type="pmid">14633804</pub-id>
</element-citation>
</ref>
<ref id="B95-medsci-07-00099"><label>95.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vanschoonbeek</surname>
<given-names>K.</given-names>
</name>
<name><surname>Thomassen</surname>
<given-names>B.J.W.</given-names>
</name>
<name><surname>Senden</surname>
<given-names>J.M.</given-names>
</name>
<name><surname>Wodzig</surname>
<given-names>W.K.W.H.</given-names>
</name>
<name><surname>van Loon</surname>
<given-names>L.J.C.</given-names>
</name>
</person-group>
<article-title>Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients</article-title>
<source>J. Nutr.</source>
<year>2006</year>
<volume>136</volume>
<fpage>977</fpage>
<lpage>980</lpage>
<pub-id pub-id-type="doi">10.1093/jn/136.4.977</pub-id>
<pub-id pub-id-type="pmid">16549460</pub-id>
</element-citation>
</ref>
<ref id="B96-medsci-07-00099"><label>96.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khare</surname>
<given-names>P.</given-names>
</name>
<name><surname>Jagtap</surname>
<given-names>S.</given-names>
</name>
<name><surname>Jain</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Baboota</surname>
<given-names>R.K.</given-names>
</name>
<name><surname>Mangal</surname>
<given-names>P.</given-names>
</name>
<name><surname>Boparai</surname>
<given-names>R.K.</given-names>
</name>
<name><surname>Bhutani</surname>
<given-names>K.K.</given-names>
</name>
<name><surname>Sharma</surname>
<given-names>S.S.</given-names>
</name>
<name><surname>Premkumar</surname>
<given-names>L.S.</given-names>
</name>
<name><surname>Kondepudi</surname>
<given-names>K.K.</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice</article-title>
<source>Biofactors</source>
<year>2016</year>
<volume>42</volume>
<fpage>201</fpage>
<lpage>211</lpage>
<pub-id pub-id-type="pmid">26893251</pub-id>
</element-citation>
</ref>
<ref id="B97-medsci-07-00099"><label>97.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ahn</surname>
<given-names>J.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>H.</given-names>
</name>
<name><surname>Im</surname>
<given-names>S.W.</given-names>
</name>
<name><surname>Jung</surname>
<given-names>C.H.</given-names>
</name>
<name><surname>Ha</surname>
<given-names>T.Y.</given-names>
</name>
</person-group>
<article-title>Allyl isothiocyanate ameliorates insulin resistance through the regulation of mitochondrial function</article-title>
<source>J. Nutr. Biochem.</source>
<year>2014</year>
<volume>25</volume>
<fpage>1026</fpage>
<lpage>1034</lpage>
<pub-id pub-id-type="doi">10.1016/j.jnutbio.2014.05.006</pub-id>
<pub-id pub-id-type="pmid">25034503</pub-id>
</element-citation>
</ref>
<ref id="B98-medsci-07-00099"><label>98.</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zsombok</surname>
<given-names>A.</given-names>
</name>
<name><surname>Derbenev</surname>
<given-names>A.V.</given-names>
</name>
</person-group>
<article-title>TRP Channels as Therapeutic Targets in Diabetes and Obesity</article-title>
<source>Pharmaceuticals (Basel)</source>
<year>2016</year>
<volume>9</volume>
<pub-id pub-id-type="doi">10.3390/ph9030050</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
</pmc>
</record>
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