Bioactive Products From Plant-Endophytic Gram-Positive Bacteria
Identifieur interne : 000552 ( Pmc/Corpus ); précédent : 000551; suivant : 000553Bioactive Products From Plant-Endophytic Gram-Positive Bacteria
Auteurs : María J. Ek-Ramos ; Ricardo Gomez-Flores ; Alonso A. Orozco-Flores ; Cristina Rodríguez-Padilla ; Guadalupe González-Ochoa ; Patricia Tamez-GuerraSource :
- Frontiers in Microbiology [ 1664-302X ] ; 2019.
Abstract
Endophytes constitute plant-colonizing microorganisms in a mutualistic symbiosis relationship. They are found in most ecosystems reducing plant crops’ biotic and abiotic stressors by stimulating immune responses, excluding plant pathogens by niche competition, and participating in antioxidant activities and phenylpropanoid metabolism, whose activation produces plant defense, structural support, and survival molecules. In fact, metabolomic studies have demonstrated that endophyte genes associated to specific metabolites are involved in plant growth promotion (PGP) by stimulating plant hormones production such as auxins and gibberellins or as plant protective agents against microbial pathogens, cancer, and insect pests, but eco-friendly and eco-safe. A number of metabolites of Gram-positive endophytes isolated from agriculture, forest, mangrove, and medicinal plants, mainly related to the Firmicutes phyla, possess distinctive biocontrol and plant growth-promoting activities. In general, Actinobacteria and
Url:
DOI: 10.3389/fmicb.2019.00463
PubMed: 30984118
PubMed Central: 6449470
Links to Exploration step
PMC:6449470Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bioactive Products From Plant-Endophytic Gram-Positive Bacteria</title>
<author><name sortKey="Ek Ramos, Maria J" sort="Ek Ramos, Maria J" uniqKey="Ek Ramos M" first="María J." last="Ek-Ramos">María J. Ek-Ramos</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gomez Flores, Ricardo" sort="Gomez Flores, Ricardo" uniqKey="Gomez Flores R" first="Ricardo" last="Gomez-Flores">Ricardo Gomez-Flores</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Orozco Flores, Alonso A" sort="Orozco Flores, Alonso A" uniqKey="Orozco Flores A" first="Alonso A." last="Orozco-Flores">Alonso A. Orozco-Flores</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rodriguez Padilla, Cristina" sort="Rodriguez Padilla, Cristina" uniqKey="Rodriguez Padilla C" first="Cristina" last="Rodríguez-Padilla">Cristina Rodríguez-Padilla</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez Ochoa, Guadalupe" sort="Gonzalez Ochoa, Guadalupe" uniqKey="Gonzalez Ochoa G" first="Guadalupe" last="González-Ochoa">Guadalupe González-Ochoa</name>
<affiliation><nlm:aff id="aff2"><institution>Departamento de Ciencias Químico Biológicas, División de Ciencias e Ingeniería, Universidad de Sonora</institution>
,<addr-line>Navojoa</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tamez Guerra, Patricia" sort="Tamez Guerra, Patricia" uniqKey="Tamez Guerra P" first="Patricia" last="Tamez-Guerra">Patricia Tamez-Guerra</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30984118</idno>
<idno type="pmc">6449470</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449470</idno>
<idno type="RBID">PMC:6449470</idno>
<idno type="doi">10.3389/fmicb.2019.00463</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000552</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000552</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bioactive Products From Plant-Endophytic Gram-Positive Bacteria</title>
<author><name sortKey="Ek Ramos, Maria J" sort="Ek Ramos, Maria J" uniqKey="Ek Ramos M" first="María J." last="Ek-Ramos">María J. Ek-Ramos</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gomez Flores, Ricardo" sort="Gomez Flores, Ricardo" uniqKey="Gomez Flores R" first="Ricardo" last="Gomez-Flores">Ricardo Gomez-Flores</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Orozco Flores, Alonso A" sort="Orozco Flores, Alonso A" uniqKey="Orozco Flores A" first="Alonso A." last="Orozco-Flores">Alonso A. Orozco-Flores</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rodriguez Padilla, Cristina" sort="Rodriguez Padilla, Cristina" uniqKey="Rodriguez Padilla C" first="Cristina" last="Rodríguez-Padilla">Cristina Rodríguez-Padilla</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gonzalez Ochoa, Guadalupe" sort="Gonzalez Ochoa, Guadalupe" uniqKey="Gonzalez Ochoa G" first="Guadalupe" last="González-Ochoa">Guadalupe González-Ochoa</name>
<affiliation><nlm:aff id="aff2"><institution>Departamento de Ciencias Químico Biológicas, División de Ciencias e Ingeniería, Universidad de Sonora</institution>
,<addr-line>Navojoa</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tamez Guerra, Patricia" sort="Tamez Guerra, Patricia" uniqKey="Tamez Guerra P" first="Patricia" last="Tamez-Guerra">Patricia Tamez-Guerra</name>
<affiliation><nlm:aff id="aff1"><institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in Microbiology</title>
<idno type="eISSN">1664-302X</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Endophytes constitute plant-colonizing microorganisms in a mutualistic symbiosis relationship. They are found in most ecosystems reducing plant crops’ biotic and abiotic stressors by stimulating immune responses, excluding plant pathogens by niche competition, and participating in antioxidant activities and phenylpropanoid metabolism, whose activation produces plant defense, structural support, and survival molecules. In fact, metabolomic studies have demonstrated that endophyte genes associated to specific metabolites are involved in plant growth promotion (PGP) by stimulating plant hormones production such as auxins and gibberellins or as plant protective agents against microbial pathogens, cancer, and insect pests, but eco-friendly and eco-safe. A number of metabolites of Gram-positive endophytes isolated from agriculture, forest, mangrove, and medicinal plants, mainly related to the Firmicutes phyla, possess distinctive biocontrol and plant growth-promoting activities. In general, Actinobacteria and <italic>Bacillus</italic>
endophytes produce aromatic compounds, lipopeptides, plant hormones, polysaccharides, and several enzymes linked to phenylpropanoid metabolism, thus representing high potential for PGP and crop management strategies. Furthermore, Actinobacteria have been shown to produce metabolites with antimicrobial and antitumor activities, useful in agriculture, medicine, and veterinary areas. The great endophytes diversity, their metabolites production, and their adaptation to stress conditions make them a suitable and unlimited source of novel metabolites, whose application could reduce agrochemicals usage in food and drugs production.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aitken, G" uniqKey="Aitken G">G. Aitken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akinsanya, M A" uniqKey="Akinsanya M">M. A. Akinsanya</name>
</author>
<author><name sortKey="Goh, J K" uniqKey="Goh J">J. K. Goh</name>
</author>
<author><name sortKey="Lim, S P" uniqKey="Lim S">S. P. Lim</name>
</author>
<author><name sortKey="Ting, A S Y" uniqKey="Ting A">A. S. Y. Ting</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alaimo, S" uniqKey="Alaimo S">S. Alaimo</name>
</author>
<author><name sortKey="Marceca, G P" uniqKey="Marceca G">G. P. Marceca</name>
</author>
<author><name sortKey="Giugno, R" uniqKey="Giugno R">R. Giugno</name>
</author>
<author><name sortKey="Ferro, A" uniqKey="Ferro A">A. Ferro</name>
</author>
<author><name sortKey="Pulvirenti, A" uniqKey="Pulvirenti A">A. Pulvirenti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aloo, B N" uniqKey="Aloo B">B. N. Aloo</name>
</author>
<author><name sortKey="Makumba, B A" uniqKey="Makumba B">B. A. Makumba</name>
</author>
<author><name sortKey="Mbega, E R" uniqKey="Mbega E">E. R. Mbega</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Armada, E" uniqKey="Armada E">E. Armada</name>
</author>
<author><name sortKey="Probanza, A" uniqKey="Probanza A">A. Probanza</name>
</author>
<author><name sortKey="Roldan, A" uniqKey="Roldan A">A. Roldán</name>
</author>
<author><name sortKey="Azc N, R" uniqKey="Azc N R">R. Azcón</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baldan, E" uniqKey="Baldan E">E. Baldan</name>
</author>
<author><name sortKey="Nigris, S" uniqKey="Nigris S">S. Nigris</name>
</author>
<author><name sortKey="Populin, F" uniqKey="Populin F">F. Populin</name>
</author>
<author><name sortKey="Zottini, M" uniqKey="Zottini M">M. Zottini</name>
</author>
<author><name sortKey="Squartini, A" uniqKey="Squartini A">A. Squartini</name>
</author>
<author><name sortKey="Baldan, B" uniqKey="Baldan B">B. Baldan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beck, H C" uniqKey="Beck H">H. C. Beck</name>
</author>
<author><name sortKey="Hansen, A M" uniqKey="Hansen A">A. M. Hansen</name>
</author>
<author><name sortKey="Lauritsen, F R" uniqKey="Lauritsen F">F. R. Lauritsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beiranvand, M" uniqKey="Beiranvand M">M. Beiranvand</name>
</author>
<author><name sortKey="Amin, M" uniqKey="Amin M">M. Amin</name>
</author>
<author><name sortKey="Hashemi Shahraki, A" uniqKey="Hashemi Shahraki A">A. Hashemi-Shahraki</name>
</author>
<author><name sortKey="Romani, B" uniqKey="Romani B">B. Romani</name>
</author>
<author><name sortKey="Yaghoubi, S" uniqKey="Yaghoubi S">S. Yaghoubi</name>
</author>
<author><name sortKey="Sadeghi, P" uniqKey="Sadeghi P">P. Sadeghi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berg, G" uniqKey="Berg G">G. Berg</name>
</author>
<author><name sortKey="Krechel, A" uniqKey="Krechel A">A. Krechel</name>
</author>
<author><name sortKey="Ditz, M" uniqKey="Ditz M">M. Ditz</name>
</author>
<author><name sortKey="Sikora, R A" uniqKey="Sikora R">R. A. Sikora</name>
</author>
<author><name sortKey="Ulrich, A" uniqKey="Ulrich A">A. Ulrich</name>
</author>
<author><name sortKey="Hallmann, J" uniqKey="Hallmann J">J. Hallmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bieber, B" uniqKey="Bieber B">B. Bieber</name>
</author>
<author><name sortKey="Nuske, J" uniqKey="Nuske J">J. Nüske</name>
</author>
<author><name sortKey="Ritzau, M" uniqKey="Ritzau M">M. Ritzau</name>
</author>
<author><name sortKey="Gr Fe, U" uniqKey="Gr Fe U">U. Gräfe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brader, G" uniqKey="Brader G">G. Brader</name>
</author>
<author><name sortKey="Compant, S" uniqKey="Compant S">S. Compant</name>
</author>
<author><name sortKey="Mitter, B" uniqKey="Mitter B">B. Mitter</name>
</author>
<author><name sortKey="Trognitz, F" uniqKey="Trognitz F">F. Trognitz</name>
</author>
<author><name sortKey="Sessitsch, A" uniqKey="Sessitsch A">A. Sessitsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cai, X C" uniqKey="Cai X">X. C. Cai</name>
</author>
<author><name sortKey="Liu, C H" uniqKey="Liu C">C. H. Liu</name>
</author>
<author><name sortKey="Wang, B T" uniqKey="Wang B">B. T. Wang</name>
</author>
<author><name sortKey="Xue, Y R" uniqKey="Xue Y">Y. R. Xue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cankar, K" uniqKey="Cankar K">K. Cankar</name>
</author>
<author><name sortKey="Kraigher, H" uniqKey="Kraigher H">H. Kraigher</name>
</author>
<author><name sortKey="Ravnikar, M" uniqKey="Ravnikar M">M. Ravnikar</name>
</author>
<author><name sortKey="Rupnik, M" uniqKey="Rupnik M">M. Rupnik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cardoso Filho, J A" uniqKey="Cardoso Filho J">J. A. Cardoso-Filho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castillo, U" uniqKey="Castillo U">U. Castillo</name>
</author>
<author><name sortKey="Harper, J K" uniqKey="Harper J">J. K. Harper</name>
</author>
<author><name sortKey="Strobel, G A" uniqKey="Strobel G">G. A. Strobel</name>
</author>
<author><name sortKey="Sears, J" uniqKey="Sears J">J. Sears</name>
</author>
<author><name sortKey="Alesi, K" uniqKey="Alesi K">K. Alesi</name>
</author>
<author><name sortKey="Ford, E" uniqKey="Ford E">E. Ford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castillo, U F" uniqKey="Castillo U">U. F. Castillo</name>
</author>
<author><name sortKey="Browne, L" uniqKey="Browne L">L. Browne</name>
</author>
<author><name sortKey="Strobel, G A" uniqKey="Strobel G">G. A. Strobel</name>
</author>
<author><name sortKey="Hess, W M" uniqKey="Hess W">W. M. Hess</name>
</author>
<author><name sortKey="Ezra, S" uniqKey="Ezra S">S. Ezra</name>
</author>
<author><name sortKey="Pacheco, G" uniqKey="Pacheco G">G. Pacheco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castillo, U F" uniqKey="Castillo U">U. F. Castillo</name>
</author>
<author><name sortKey="Strobel, G A" uniqKey="Strobel G">G. A. Strobel</name>
</author>
<author><name sortKey="Ford, E J" uniqKey="Ford E">E. J. Ford</name>
</author>
<author><name sortKey="Hess, W M" uniqKey="Hess W">W. M. Hess</name>
</author>
<author><name sortKey="Porter, H" uniqKey="Porter H">H. Porter</name>
</author>
<author><name sortKey="Jensen, J B" uniqKey="Jensen J">J. B. Jensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castillo, U F" uniqKey="Castillo U">U. F. Castillo</name>
</author>
<author><name sortKey="Strobel, G A" uniqKey="Strobel G">G. A. Strobel</name>
</author>
<author><name sortKey="Mullenberg, K" uniqKey="Mullenberg K">K. Mullenberg</name>
</author>
<author><name sortKey="Condron, M M" uniqKey="Condron M">M. M. Condron</name>
</author>
<author><name sortKey="Teplow, D B" uniqKey="Teplow D">D. B. Teplow</name>
</author>
<author><name sortKey="Folgiano, V" uniqKey="Folgiano V">V. Folgiano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castro, R A" uniqKey="Castro R">R. A. Castro</name>
</author>
<author><name sortKey="Quecine, M C" uniqKey="Quecine M">M. C. Quecine</name>
</author>
<author><name sortKey="Lacava, P T" uniqKey="Lacava P">P. T. Lacava</name>
</author>
<author><name sortKey="Batista, B D" uniqKey="Batista B">B. D. Batista</name>
</author>
<author><name sortKey="Luvizotto, D M" uniqKey="Luvizotto D">D. M. Luvizotto</name>
</author>
<author><name sortKey="Marcon, J" uniqKey="Marcon J">J. Marcon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cazorla, F M" uniqKey="Cazorla F">F. M. Cazorla</name>
</author>
<author><name sortKey="Romero, D" uniqKey="Romero D">D. Romero</name>
</author>
<author><name sortKey="Perez Garcia, A" uniqKey="Perez Garcia A">A. Pérez-García</name>
</author>
<author><name sortKey="Lugtenberg, B J J" uniqKey="Lugtenberg B">B. J. J. Lugtenberg</name>
</author>
<author><name sortKey="Vicente, A D" uniqKey="Vicente A">A. D. Vicente</name>
</author>
<author><name sortKey="Bloemberg, G" uniqKey="Bloemberg G">G. Bloemberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chandrakar, S" uniqKey="Chandrakar S">S. Chandrakar</name>
</author>
<author><name sortKey="Gupta, A K" uniqKey="Gupta A">A. K. Gupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chandrakar, S" uniqKey="Chandrakar S">S. Chandrakar</name>
</author>
<author><name sortKey="Gupta, A K" uniqKey="Gupta A">A. K. Gupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chatterjee, P" uniqKey="Chatterjee P">P. Chatterjee</name>
</author>
<author><name sortKey="Samaddar, S" uniqKey="Samaddar S">S. Samaddar</name>
</author>
<author><name sortKey="Niinemets, U" uniqKey="Niinemets U">Ü. Niinemets</name>
</author>
<author><name sortKey="Sa, T M" uniqKey="Sa T">T. M. Sa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Y T" uniqKey="Chen Y">Y. T. Chen</name>
</author>
<author><name sortKey="Yuan, Q" uniqKey="Yuan Q">Q. Yuan</name>
</author>
<author><name sortKey="Shan, L T" uniqKey="Shan L">L. T. Shan</name>
</author>
<author><name sortKey="Lin, M A" uniqKey="Lin M">M. A. Lin</name>
</author>
<author><name sortKey="Cheng, D Q" uniqKey="Cheng D">D. Q. Cheng</name>
</author>
<author><name sortKey="Li, C Y" uniqKey="Li C">C. Y. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chinedum, I E" uniqKey="Chinedum I">I. E. Chinedum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christina, A" uniqKey="Christina A">A. Christina</name>
</author>
<author><name sortKey="Christapher, V" uniqKey="Christapher V">V. Christapher</name>
</author>
<author><name sortKey="Bhore, S J" uniqKey="Bhore S">S. J. Bhore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Compant, S" uniqKey="Compant S">S. Compant</name>
</author>
<author><name sortKey="Mitter, B" uniqKey="Mitter B">B. Mitter</name>
</author>
<author><name sortKey="Colli Mull, J G" uniqKey="Colli Mull J">J. G. Colli-Mull</name>
</author>
<author><name sortKey="Gangl, H" uniqKey="Gangl H">H. Gangl</name>
</author>
<author><name sortKey="Sessitsch, A" uniqKey="Sessitsch A">A. Sessitsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Damodaran, T" uniqKey="Damodaran T">T. Damodaran</name>
</author>
<author><name sortKey="Rai, R B" uniqKey="Rai R">R. B. Rai</name>
</author>
<author><name sortKey="Jha, S K" uniqKey="Jha S">S. K. Jha</name>
</author>
<author><name sortKey="Kannan, R" uniqKey="Kannan R">R. Kannan</name>
</author>
<author><name sortKey="Pandey, B K" uniqKey="Pandey B">B. K. Pandey</name>
</author>
<author><name sortKey="Sah, V" uniqKey="Sah V">V. Sah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Lima Proc Pio, R E" uniqKey="De Lima Proc Pio R">R. E. de Lima Procópio</name>
</author>
<author><name sortKey="Da Silva, I R" uniqKey="Da Silva I">I. R. da Silva</name>
</author>
<author><name sortKey="Martins, M K" uniqKey="Martins M">M. K. Martins</name>
</author>
<author><name sortKey="De Azevedo, J L" uniqKey="De Azevedo J">J. L. de Azevedo</name>
</author>
<author><name sortKey="De Araujo, J M" uniqKey="De Araujo J">J. M. de Araújo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Melo Pereira, G V" uniqKey="De Melo Pereira G">G. V. de Melo-Pereira</name>
</author>
<author><name sortKey="Magalhaes, K T" uniqKey="Magalhaes K">K. T. Magalhães</name>
</author>
<author><name sortKey="Lorenzetii, E R" uniqKey="Lorenzetii E">E. R. Lorenzetii</name>
</author>
<author><name sortKey="Souza, T P" uniqKey="Souza T">T. P. Souza</name>
</author>
<author><name sortKey="Schwan, R F" uniqKey="Schwan R">R. F. Schwan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Demain, A L" uniqKey="Demain A">A. L. Demain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y. Deng</name>
</author>
<author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y. Zhu</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name>
</author>
<author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name>
</author>
<author><name sortKey="Zheng, J" uniqKey="Zheng J">J. Zheng</name>
</author>
<author><name sortKey="Li, R" uniqKey="Li R">R. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diale, M O" uniqKey="Diale M">M. O. Diale</name>
</author>
<author><name sortKey="Ubomba Jaswa, E" uniqKey="Ubomba Jaswa E">E. Ubomba-Jaswa</name>
</author>
<author><name sortKey="Serepa Dlamini, M H" uniqKey="Serepa Dlamini M">M. H. Serepa-Dlamini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, L" uniqKey="Ding L">L. Ding</name>
</author>
<author><name sortKey="Maier, A" uniqKey="Maier A">A. Maier</name>
</author>
<author><name sortKey="Fiebig, H H" uniqKey="Fiebig H">H. H. Fiebig</name>
</author>
<author><name sortKey="Lin, W H" uniqKey="Lin W">W. H. Lin</name>
</author>
<author><name sortKey="Hertweck, C" uniqKey="Hertweck C">C. Hertweck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, L" uniqKey="Ding L">L. Ding</name>
</author>
<author><name sortKey="Munch, J" uniqKey="Munch J">J. Münch</name>
</author>
<author><name sortKey="Goerls, H" uniqKey="Goerls H">H. Goerls</name>
</author>
<author><name sortKey="Maier, A" uniqKey="Maier A">A. Maier</name>
</author>
<author><name sortKey="Fiebig, H H" uniqKey="Fiebig H">H. H. Fiebig</name>
</author>
<author><name sortKey="Lin, W H" uniqKey="Lin W">W. H. Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Deeb, B" uniqKey="El Deeb B">B. El-Deeb</name>
</author>
<author><name sortKey="Fayez, K" uniqKey="Fayez K">K. Fayez</name>
</author>
<author><name sortKey="Gherbawy, Y" uniqKey="Gherbawy Y">Y. Gherbawy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eljounaidi, K" uniqKey="Eljounaidi K">K. Eljounaidi</name>
</author>
<author><name sortKey="Lee, S K" uniqKey="Lee S">S. K. Lee</name>
</author>
<author><name sortKey="Bae, H" uniqKey="Bae H">H. Bae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Etesami, H" uniqKey="Etesami H">H. Etesami</name>
</author>
<author><name sortKey="Alikhani, H A" uniqKey="Alikhani H">H. A. Alikhani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ezra, D" uniqKey="Ezra D">D. Ezra</name>
</author>
<author><name sortKey="Castillo, U F" uniqKey="Castillo U">U. F. Castillo</name>
</author>
<author><name sortKey="Strobel, G A" uniqKey="Strobel G">G. A. Strobel</name>
</author>
<author><name sortKey="Hess, W M" uniqKey="Hess W">W. M. Hess</name>
</author>
<author><name sortKey="Porter, H" uniqKey="Porter H">H. Porter</name>
</author>
<author><name sortKey="Jensen, J B" uniqKey="Jensen J">J. B. Jensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrigo, D" uniqKey="Ferrigo D">D. Ferrigo</name>
</author>
<author><name sortKey="Causin, R" uniqKey="Causin R">R. Causin</name>
</author>
<author><name sortKey="Raiola, A" uniqKey="Raiola A">A. Raiola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fikri, A S I" uniqKey="Fikri A">A. S. I. Fikri</name>
</author>
<author><name sortKey="Rahman, I A" uniqKey="Rahman I">I. A. Rahman</name>
</author>
<author><name sortKey="Nor, N S M" uniqKey="Nor N">N. S. M. Nor</name>
</author>
<author><name sortKey="Hamzah, A" uniqKey="Hamzah A">A. Hamzah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frank, A" uniqKey="Frank A">A. Frank</name>
</author>
<author><name sortKey="Saldierna Guzman, J" uniqKey="Saldierna Guzman J">J. Saldierna-Guzmán</name>
</author>
<author><name sortKey="Shay, J" uniqKey="Shay J">J. Shay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gagne Bourque, F" uniqKey="Gagne Bourque F">F. Gagné-Bourque</name>
</author>
<author><name sortKey="Mayer, B B F" uniqKey="Mayer B">B. B. F. Mayer</name>
</author>
<author><name sortKey="Charron, J B B" uniqKey="Charron J">J.-B. B. Charron</name>
</author>
<author><name sortKey="Vali, H" uniqKey="Vali H">H. Vali</name>
</author>
<author><name sortKey="Bertrand, A" uniqKey="Bertrand A">A. Bertrand</name>
</author>
<author><name sortKey="Jabaji, S" uniqKey="Jabaji S">S. Jabaji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gamez, R" uniqKey="Gamez R">R. Gamez</name>
</author>
<author><name sortKey="Cardinale, M" uniqKey="Cardinale M">M. Cardinale</name>
</author>
<author><name sortKey="Montes, M" uniqKey="Montes M">M. Montes</name>
</author>
<author><name sortKey="Ramirez, S" uniqKey="Ramirez S">S. Ramirez</name>
</author>
<author><name sortKey="Schnell, S" uniqKey="Schnell S">S. Schnell</name>
</author>
<author><name sortKey="Rodriguez, F" uniqKey="Rodriguez F">F. Rodriguez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gayathri, P" uniqKey="Gayathri P">P. Gayathri</name>
</author>
<author><name sortKey="Muralikrishnan, V" uniqKey="Muralikrishnan V">V. Muralikrishnan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghadin, N" uniqKey="Ghadin N">N. Ghadin</name>
</author>
<author><name sortKey="Zin, N M" uniqKey="Zin N">N. M. Zin</name>
</author>
<author><name sortKey="Sabaratnam, V" uniqKey="Sabaratnam V">V. Sabaratnam</name>
</author>
<author><name sortKey="Badya, N" uniqKey="Badya N">N. Badya</name>
</author>
<author><name sortKey="Basri, D F" uniqKey="Basri D">D. F. Basri</name>
</author>
<author><name sortKey="Lian, H H" uniqKey="Lian H">H. H. Lian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giassi, V" uniqKey="Giassi V">V. Giassi</name>
</author>
<author><name sortKey="Kiritani, C" uniqKey="Kiritani C">C. Kiritani</name>
</author>
<author><name sortKey="Kupper, K C" uniqKey="Kupper K">K. C. Kupper</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Gond, S K" uniqKey="Gond S">S. K. Gond</name>
</author>
<author><name sortKey="Bergen, M S" uniqKey="Bergen M">M. S. Bergen</name>
</author>
<author><name sortKey="Torres, M S" uniqKey="Torres M">M. S. Torres</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gowtham, H G" uniqKey="Gowtham H">H. G. Gowtham</name>
</author>
<author><name sortKey="Murali, M" uniqKey="Murali M">M. Murali</name>
</author>
<author><name sortKey="Singh, S B" uniqKey="Singh S">S. B. Singh</name>
</author>
<author><name sortKey="Lakshmeesha, T R" uniqKey="Lakshmeesha T">T. R. Lakshmeesha</name>
</author>
<author><name sortKey="Murthy, K N" uniqKey="Murthy K">K. N. Murthy</name>
</author>
<author><name sortKey="Amruthesh, K N" uniqKey="Amruthesh K">K. N. Amruthesh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grady, E N" uniqKey="Grady E">E. N. Grady</name>
</author>
<author><name sortKey="Macdonald, J" uniqKey="Macdonald J">J. MacDonald</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name>
</author>
<author><name sortKey="Richman, A" uniqKey="Richman A">A. Richman</name>
</author>
<author><name sortKey="Yuan, Z C" uniqKey="Yuan Z">Z. C. Yuan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guan, S H" uniqKey="Guan S">S. H. Guan</name>
</author>
<author><name sortKey="Sattler, I" uniqKey="Sattler I">I. Sattler</name>
</author>
<author><name sortKey="Lin, W H" uniqKey="Lin W">W. H. Lin</name>
</author>
<author><name sortKey="Guo, D A" uniqKey="Guo D">D. A. Guo</name>
</author>
<author><name sortKey="Grabley, S" uniqKey="Grabley S">S. Grabley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gutierrez, R M" uniqKey="Gutierrez R">R. M. Gutierrez</name>
</author>
<author><name sortKey="Gonzalez, A M" uniqKey="Gonzalez A">A. M. Gonzalez</name>
</author>
<author><name sortKey="Ramirez, A M" uniqKey="Ramirez A">A. M. Ramirez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haidar, R" uniqKey="Haidar R">R. Haidar</name>
</author>
<author><name sortKey="Roudet, J" uniqKey="Roudet J">J. Roudet</name>
</author>
<author><name sortKey="Bonnard, O" uniqKey="Bonnard O">O. Bonnard</name>
</author>
<author><name sortKey="Dufour, M C" uniqKey="Dufour M">M. C. Dufour</name>
</author>
<author><name sortKey="Corio Costet, M F" uniqKey="Corio Costet M">M. F. Corio-Costet</name>
</author>
<author><name sortKey="Fert, M" uniqKey="Fert M">M. Fert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Housman, G" uniqKey="Housman G">G. Housman</name>
</author>
<author><name sortKey="Byler, S" uniqKey="Byler S">S. Byler</name>
</author>
<author><name sortKey="Heerboth, S" uniqKey="Heerboth S">S. Heerboth</name>
</author>
<author><name sortKey="Lapinska, K" uniqKey="Lapinska K">K. Lapinska</name>
</author>
<author><name sortKey="Longacre, M" uniqKey="Longacre M">M. Longacre</name>
</author>
<author><name sortKey="Snyder, N" uniqKey="Snyder N">N. Snyder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, H Q" uniqKey="Hu H">H. Q. Hu</name>
</author>
<author><name sortKey="Li, X S" uniqKey="Li X">X. S. Li</name>
</author>
<author><name sortKey="He, H" uniqKey="He H">H. He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Igarashi, Y" uniqKey="Igarashi Y">Y. Igarashi</name>
</author>
<author><name sortKey="Miura, S S" uniqKey="Miura S">S. S. Miura</name>
</author>
<author><name sortKey="Fujita, T" uniqKey="Fujita T">T. Fujita</name>
</author>
<author><name sortKey="Furumai, T" uniqKey="Furumai T">T. Furumai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Igarashi, Y" uniqKey="Igarashi Y">Y. Igarashi</name>
</author>
<author><name sortKey="Trujillo, M E" uniqKey="Trujillo M">M. E. Trujillo</name>
</author>
<author><name sortKey="Martinez Molina, E" uniqKey="Martinez Molina E">E. Martínez-Molina</name>
</author>
<author><name sortKey="Yanase, S" uniqKey="Yanase S">S. Yanase</name>
</author>
<author><name sortKey="Miyanaga, S" uniqKey="Miyanaga S">S. Miyanaga</name>
</author>
<author><name sortKey="Obata, T" uniqKey="Obata T">T. Obata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inahashi, Y" uniqKey="Inahashi Y">Y. Inahashi</name>
</author>
<author><name sortKey="Iwatsuki, M" uniqKey="Iwatsuki M">M. Iwatsuki</name>
</author>
<author><name sortKey="Ishiyama, A" uniqKey="Ishiyama A">A. Ishiyama</name>
</author>
<author><name sortKey="Namatame, M" uniqKey="Namatame M">M. Namatame</name>
</author>
<author><name sortKey="Nishihara Tsukashima, A" uniqKey="Nishihara Tsukashima A">A. Nishihara-Tsukashima</name>
</author>
<author><name sortKey="Matsumoto, A" uniqKey="Matsumoto A">A. Matsumoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inahashi, Y" uniqKey="Inahashi Y">Y. Inahashi</name>
</author>
<author><name sortKey="Matsumoto, A" uniqKey="Matsumoto A">A. Matsumoto</name>
</author>
<author><name sortKey="Mura, S" uniqKey="Mura S">S. Mura</name>
</author>
<author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y. Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Indrawati, I" uniqKey="Indrawati I">I. Indrawati</name>
</author>
<author><name sortKey="Rossiana, N" uniqKey="Rossiana N">N. Rossiana</name>
</author>
<author><name sortKey="Hidayat, T R" uniqKey="Hidayat T">T. R. Hidayat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jakubiec Krzesniak, K" uniqKey="Jakubiec Krzesniak K">K. Jakubiec-Krzesniak</name>
</author>
<author><name sortKey="Rajnisz Mateusiak, A" uniqKey="Rajnisz Mateusiak A">A. Rajnisz-Mateusiak</name>
</author>
<author><name sortKey="Guspiel, A" uniqKey="Guspiel A">A. Guspiel</name>
</author>
<author><name sortKey="Ziemska, J" uniqKey="Ziemska J">J. Ziemska</name>
</author>
<author><name sortKey="Solecka, J" uniqKey="Solecka J">J. Solecka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, Z" uniqKey="Jiang Z">Z. Jiang</name>
</author>
<author><name sortKey="Tuo, L" uniqKey="Tuo L">L. Tuo</name>
</author>
<author><name sortKey="Huang, D" uniqKey="Huang D">D. Huang</name>
</author>
<author><name sortKey="Osterman, I A" uniqKey="Osterman I">I. A. Osterman</name>
</author>
<author><name sortKey="Tyurin, A" uniqKey="Tyurin A">A. Tyurin</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnston Monje, D" uniqKey="Johnston Monje D">D. Johnston-Monje</name>
</author>
<author><name sortKey="Raizada, M N" uniqKey="Raizada M">M. N. Raizada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlidag, H" uniqKey="Karlidag H">H. Karlidag</name>
</author>
<author><name sortKey="Esitken, A" uniqKey="Esitken A">A. Esitken</name>
</author>
<author><name sortKey="Yildirim, E" uniqKey="Yildirim E">E. Yildirim</name>
</author>
<author><name sortKey="Donmez, M F" uniqKey="Donmez M">M. F. Donmez</name>
</author>
<author><name sortKey="Turan, M" uniqKey="Turan M">M. Turan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katagiri, K" uniqKey="Katagiri K">K. Katagiri</name>
</author>
<author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T. Yoshida</name>
</author>
<author><name sortKey="Sato, K" uniqKey="Sato K">K. Sato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kekuda, T P" uniqKey="Kekuda T">T. P. Kekuda</name>
</author>
<author><name sortKey="Shobha, K S" uniqKey="Shobha K">K. S. Shobha</name>
</author>
<author><name sortKey="Onkarappa, R" uniqKey="Onkarappa R">R. Onkarappa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khianngam, S" uniqKey="Khianngam S">S. Khianngam</name>
</author>
<author><name sortKey="Techakriengkrai, T" uniqKey="Techakriengkrai T">T. Techakriengkrai</name>
</author>
<author><name sortKey="Raksasiri, B V" uniqKey="Raksasiri B">B. V. Raksasiri</name>
</author>
<author><name sortKey="Kanjanamaneesathian, M" uniqKey="Kanjanamaneesathian M">M. Kanjanamaneesathian</name>
</author>
<author><name sortKey="Tanasupawat, S" uniqKey="Tanasupawat S">S. Tanasupawat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, N" uniqKey="Kim N">N. Kim</name>
</author>
<author><name sortKey="Shin, J C" uniqKey="Shin J">J. C. Shin</name>
</author>
<author><name sortKey="Kim, W" uniqKey="Kim W">W. Kim</name>
</author>
<author><name sortKey="Hwang, B Y" uniqKey="Hwang B">B. Y. Hwang</name>
</author>
<author><name sortKey="Kim, B S" uniqKey="Kim B">B. S. Kim</name>
</author>
<author><name sortKey="Hong, Y S" uniqKey="Hong Y">Y. S. Hong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koskim Ki, J J" uniqKey="Koskim Ki J">J. J. Koskimäki</name>
</author>
<author><name sortKey="Pirttil, A M" uniqKey="Pirttil A">A. M. Pirttilä</name>
</author>
<author><name sortKey="Ihantola, E L" uniqKey="Ihantola E">E. L. Ihantola</name>
</author>
<author><name sortKey="Halonen, O" uniqKey="Halonen O">O. Halonen</name>
</author>
<author><name sortKey="Frank, A C" uniqKey="Frank A">A. C. Frank</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name>
</author>
<author><name sortKey="Soares, M A" uniqKey="Soares M">M. A. Soares</name>
</author>
<author><name sortKey="Torres, M S" uniqKey="Torres M">M. S. Torres</name>
</author>
<author><name sortKey="Bergen, M" uniqKey="Bergen M">M. Bergen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name>
</author>
<author><name sortKey="Huang, L" uniqKey="Huang L">L. Huang</name>
</author>
<author><name sortKey="Buchenauer, H" uniqKey="Buchenauer H">H. Buchenauer</name>
</author>
<author><name sortKey="Kang, Z" uniqKey="Kang Z">Z. Kang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Jia, X" uniqKey="Jia X">X. Jia</name>
</author>
<author><name sortKey="Lu, W" uniqKey="Lu W">W. Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lodewyckx, C" uniqKey="Lodewyckx C">C. Lodewyckx</name>
</author>
<author><name sortKey="Vangronsveld, J" uniqKey="Vangronsveld J">J. Vangronsveld</name>
</author>
<author><name sortKey="Porteous, F" uniqKey="Porteous F">F. Porteous</name>
</author>
<author><name sortKey="Moore, E R B" uniqKey="Moore E">E. R. B. Moore</name>
</author>
<author><name sortKey="Taghavi, S" uniqKey="Taghavi S">S. Taghavi</name>
</author>
<author><name sortKey="Mezgeay, M" uniqKey="Mezgeay M">M. Mezgeay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="L Pez Fernandez, S" uniqKey="L Pez Fernandez S">S. Lòpez-Fernàndez</name>
</author>
<author><name sortKey="Compant, S" uniqKey="Compant S">S. Compant</name>
</author>
<author><name sortKey="Vrhovsek, U" uniqKey="Vrhovsek U">U. Vrhovsek</name>
</author>
<author><name sortKey="Bianchedi, P L" uniqKey="Bianchedi P">P. L. Bianchedi</name>
</author>
<author><name sortKey="Sessitsch, A" uniqKey="Sessitsch A">A. Sessitsch</name>
</author>
<author><name sortKey="Pertot, I" uniqKey="Pertot I">I. Pertot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, C" uniqKey="Lu C">C. Lu</name>
</author>
<author><name sortKey="Shen, Y" uniqKey="Shen Y">Y. Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, S" uniqKey="Luo S">S. Luo</name>
</author>
<author><name sortKey="Xu, T" uniqKey="Xu T">T. Xu</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
<author><name sortKey="Rao, C" uniqKey="Rao C">C. Rao</name>
</author>
<author><name sortKey="Xiao, X" uniqKey="Xiao X">X. Xiao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manikprabhu, D" uniqKey="Manikprabhu D">D. Manikprabhu</name>
</author>
<author><name sortKey="Li, W J" uniqKey="Li W">W. J. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsumoto, A" uniqKey="Matsumoto A">A. Matsumoto</name>
</author>
<author><name sortKey="Takahashi, Y" uniqKey="Takahashi Y">Y. Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mingma, R" uniqKey="Mingma R">R. Mingma</name>
</author>
<author><name sortKey="Pathom Aree, W" uniqKey="Pathom Aree W">W. Pathom-aree</name>
</author>
<author><name sortKey="Trakulnaleamsai, S" uniqKey="Trakulnaleamsai S">S. Trakulnaleamsai</name>
</author>
<author><name sortKey="Thamchaipenet, A" uniqKey="Thamchaipenet A">A. Thamchaipenet</name>
</author>
<author><name sortKey="Duangmal, K" uniqKey="Duangmal K">K. Duangmal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohamad, O A" uniqKey="Mohamad O">O. A. Mohamad</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L. Li</name>
</author>
<author><name sortKey="Ma, J B" uniqKey="Ma J">J. B. Ma</name>
</author>
<author><name sortKey="Hatab, S" uniqKey="Hatab S">S. Hatab</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L. Xu</name>
</author>
<author><name sortKey="Guo, J W" uniqKey="Guo J">J. W. Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nautiyal, C S" uniqKey="Nautiyal C">C. S. Nautiyal</name>
</author>
<author><name sortKey="Srivastava, S" uniqKey="Srivastava S">S. Srivastava</name>
</author>
<author><name sortKey="Chauhan, P S" uniqKey="Chauhan P">P. S. Chauhan</name>
</author>
<author><name sortKey="Seem, K" uniqKey="Seem K">K. Seem</name>
</author>
<author><name sortKey="Mishra, A" uniqKey="Mishra A">A. Mishra</name>
</author>
<author><name sortKey="Sopory, S K" uniqKey="Sopory S">S. K. Sopory</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nehra, V" uniqKey="Nehra V">V. Nehra</name>
</author>
<author><name sortKey="Saharan, B S" uniqKey="Saharan B">B. S. Saharan</name>
</author>
<author><name sortKey="Choudhary, M" uniqKey="Choudhary M">M. Choudhary</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ongena, M" uniqKey="Ongena M">M. Ongena</name>
</author>
<author><name sortKey="Jacques, P" uniqKey="Jacques P">P. Jacques</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pandey, P K" uniqKey="Pandey P">P. K. Pandey</name>
</author>
<author><name sortKey="Singh, S" uniqKey="Singh S">S. Singh</name>
</author>
<author><name sortKey="Singh, M C" uniqKey="Singh M">M. C. Singh</name>
</author>
<author><name sortKey="Singh, A K" uniqKey="Singh A">A. K. Singh</name>
</author>
<author><name sortKey="Yadav, S K" uniqKey="Yadav S">S. K. Yadav</name>
</author>
<author><name sortKey="Pandey, A K" uniqKey="Pandey A">A. K. Pandey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paungfoo Lonhienne, C" uniqKey="Paungfoo Lonhienne C">C. Paungfoo-Lonhienne</name>
</author>
<author><name sortKey="Rentsch, D" uniqKey="Rentsch D">D. Rentsch</name>
</author>
<author><name sortKey="Robatzek, S" uniqKey="Robatzek S">S. Robatzek</name>
</author>
<author><name sortKey="Webb, R I" uniqKey="Webb R">R. I. Webb</name>
</author>
<author><name sortKey="Sagulenko, E" uniqKey="Sagulenko E">E. Sagulenko</name>
</author>
<author><name sortKey="N Sholm, T" uniqKey="N Sholm T">T. Näsholm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pe A Yam, L P" uniqKey="Pe A Yam L">L. P. Peña-Yam</name>
</author>
<author><name sortKey="Ruiz Sanchez, E" uniqKey="Ruiz Sanchez E">E. Ruíz-Sánchez</name>
</author>
<author><name sortKey="Barboza Corona, J E" uniqKey="Barboza Corona J">J. E. Barboza-Corona</name>
</author>
<author><name sortKey="Reyes Ramirez, A" uniqKey="Reyes Ramirez A">A. Reyes-Ramírez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pieterse, C M J" uniqKey="Pieterse C">C. M. J. Pieterse</name>
</author>
<author><name sortKey="Zamioudis, C" uniqKey="Zamioudis C">C. Zamioudis</name>
</author>
<author><name sortKey="Berendsen, R L" uniqKey="Berendsen R">R. L. Berendsen</name>
</author>
<author><name sortKey="Weller, D M" uniqKey="Weller D">D. M. Weller</name>
</author>
<author><name sortKey="Van Wees, S C M" uniqKey="Van Wees S">S. C. M. Van Wees</name>
</author>
<author><name sortKey="Bakker, P A H M" uniqKey="Bakker P">P. A. H. M. Bakker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Posada, L F" uniqKey="Posada L">L. F. Posada</name>
</author>
<author><name sortKey="Alvarez, J C" uniqKey="Alvarez J">J. C. Álvarez</name>
</author>
<author><name sortKey="Romero Tabarez, M" uniqKey="Romero Tabarez M">M. Romero-Tabarez</name>
</author>
<author><name sortKey="De Bashan, L" uniqKey="De Bashan L">L. de-Bashan</name>
</author>
<author><name sortKey="Villegas Escobar, V" uniqKey="Villegas Escobar V">V. Villegas-Escobar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pratiwi, R H" uniqKey="Pratiwi R">R. H. Pratiwi</name>
</author>
<author><name sortKey="Hanafi, M" uniqKey="Hanafi M">M. Hanafi</name>
</author>
<author><name sortKey="Artanti, N" uniqKey="Artanti N">N. Artanti</name>
</author>
<author><name sortKey="Pratiwi, R D" uniqKey="Pratiwi R">R. D. Pratiwi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qin, S" uniqKey="Qin S">S. Qin</name>
</author>
<author><name sortKey="Xing, K" uniqKey="Xing K">K. Xing</name>
</author>
<author><name sortKey="Jiang, J H" uniqKey="Jiang J">J. H. Jiang</name>
</author>
<author><name sortKey="Xu, L H" uniqKey="Xu L">L. H. Xu</name>
</author>
<author><name sortKey="Li, W J" uniqKey="Li W">W. J. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raaijmakers, J M" uniqKey="Raaijmakers J">J. M. Raaijmakers</name>
</author>
<author><name sortKey="De Bruijn, I" uniqKey="De Bruijn I">I. de Bruijn</name>
</author>
<author><name sortKey="Nybroe, O" uniqKey="Nybroe O">O. Nybroe</name>
</author>
<author><name sortKey="Ongena, M" uniqKey="Ongena M">M. Ongena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rado, R" uniqKey="Rado R">R. Rado</name>
</author>
<author><name sortKey="Andrianarisoa, B" uniqKey="Andrianarisoa B">B. Andrianarisoa</name>
</author>
<author><name sortKey="Ravelomanantsoa, S" uniqKey="Ravelomanantsoa S">S. Ravelomanantsoa</name>
</author>
<author><name sortKey="Rakotoarimanga, N" uniqKey="Rakotoarimanga N">N. Rakotoarimanga</name>
</author>
<author><name sortKey="Rahetlah, V" uniqKey="Rahetlah V">V. Rahetlah</name>
</author>
<author><name sortKey="Fienena, F R" uniqKey="Fienena F">F. R. Fienena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramamoorthy, S" uniqKey="Ramamoorthy S">S. Ramamoorthy</name>
</author>
<author><name sortKey="Gnanakan, A" uniqKey="Gnanakan A">A. Gnanakan</name>
</author>
<author><name sortKey="Lakshmana, S S" uniqKey="Lakshmana S">S. S. Lakshmana</name>
</author>
<author><name sortKey="Meivelu, M" uniqKey="Meivelu M">M. Meivelu</name>
</author>
<author><name sortKey="Jeganathan, A" uniqKey="Jeganathan A">A. Jeganathan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reinhold Hurek, B" uniqKey="Reinhold Hurek B">B. Reinhold-Hurek</name>
</author>
<author><name sortKey="Hurek, T" uniqKey="Hurek T">T. Hurek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renu, S" uniqKey="Renu S">S. Renu</name>
</author>
<author><name sortKey="Monisha, K" uniqKey="Monisha K">K. Monisha</name>
</author>
<author><name sortKey="Lal, R" uniqKey="Lal R">R. Lal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenblueth, M" uniqKey="Rosenblueth M">M. Rosenblueth</name>
</author>
<author><name sortKey="Martinez Romero, E" uniqKey="Martinez Romero E">E. Martínez-Romero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ryan, R P" uniqKey="Ryan R">R. P. Ryan</name>
</author>
<author><name sortKey="Germaine, K" uniqKey="Germaine K">K. Germaine</name>
</author>
<author><name sortKey="Franks, A" uniqKey="Franks A">A. Franks</name>
</author>
<author><name sortKey="Ryan, D J" uniqKey="Ryan D">D. J. Ryan</name>
</author>
<author><name sortKey="Dowling, D N" uniqKey="Dowling D">D. N. Dowling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sabate, D C" uniqKey="Sabate D">D. C. Sabaté</name>
</author>
<author><name sortKey="Brandan, C P" uniqKey="Brandan C">C. P. Brandan</name>
</author>
<author><name sortKey="Petroselli, G" uniqKey="Petroselli G">G. Petroselli</name>
</author>
<author><name sortKey="Erra Balsells, R" uniqKey="Erra Balsells R">R. Erra-Balsells</name>
</author>
<author><name sortKey="Audisio, M C" uniqKey="Audisio M">M. C. Audisio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Safiyazov, J S" uniqKey="Safiyazov J">J. S. Safiyazov</name>
</author>
<author><name sortKey="Mannanov, R N" uniqKey="Mannanov R">R. N. Mannanov</name>
</author>
<author><name sortKey="Sattarova, R K" uniqKey="Sattarova R">R. K. Sattarova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santoyo, G" uniqKey="Santoyo G">G. Santoyo</name>
</author>
<author><name sortKey="Moreno Hagelsieb, G" uniqKey="Moreno Hagelsieb G">G. Moreno-Hagelsieb</name>
</author>
<author><name sortKey="Del Orozco Mosqueda, M C" uniqKey="Del Orozco Mosqueda M">M. C. del Orozco-Mosqueda</name>
</author>
<author><name sortKey="Glick, B R" uniqKey="Glick B">B. R. Glick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schulz, B" uniqKey="Schulz B">B. Schulz</name>
</author>
<author><name sortKey="Boyle, C" uniqKey="Boyle C">C. Boyle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Selvakumar, G" uniqKey="Selvakumar G">G. Selvakumar</name>
</author>
<author><name sortKey="Kundu, S" uniqKey="Kundu S">S. Kundu</name>
</author>
<author><name sortKey="Joshi, P" uniqKey="Joshi P">P. Joshi</name>
</author>
<author><name sortKey="Nazim, S" uniqKey="Nazim S">S. Nazim</name>
</author>
<author><name sortKey="Gupta, A D" uniqKey="Gupta A">A. D. Gupta</name>
</author>
<author><name sortKey="Gupta, H S" uniqKey="Gupta H">H. S. Gupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seo, W T" uniqKey="Seo W">W. T. Seo</name>
</author>
<author><name sortKey="Lim, W J" uniqKey="Lim W">W. J. Lim</name>
</author>
<author><name sortKey="Kim, E J" uniqKey="Kim E">E. J. Kim</name>
</author>
<author><name sortKey="Yun, H D" uniqKey="Yun H">H. D. Yun</name>
</author>
<author><name sortKey="Lee, Y H" uniqKey="Lee Y">Y. H. Lee</name>
</author>
<author><name sortKey="Cho, K M" uniqKey="Cho K">K. M. Cho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shahzad, R" uniqKey="Shahzad R">R. Shahzad</name>
</author>
<author><name sortKey="Waqas, M" uniqKey="Waqas M">M. Waqas</name>
</author>
<author><name sortKey="Khan, A L" uniqKey="Khan A">A. L. Khan</name>
</author>
<author><name sortKey="Asaf, S" uniqKey="Asaf S">S. Asaf</name>
</author>
<author><name sortKey="Khan, M A" uniqKey="Khan M">M. A. Khan</name>
</author>
<author><name sortKey="Kang, S M" uniqKey="Kang S">S. M. Kang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shimizu, M" uniqKey="Shimizu M">M. Shimizu</name>
</author>
<author><name sortKey="Nakagawa, Y" uniqKey="Nakagawa Y">Y. Nakagawa</name>
</author>
<author><name sortKey="Yukio, S A T O" uniqKey="Yukio S">S. A. T. O. Yukio</name>
</author>
<author><name sortKey="Furumai, T" uniqKey="Furumai T">T. Furumai</name>
</author>
<author><name sortKey="Igarashi, Y" uniqKey="Igarashi Y">Y. Igarashi</name>
</author>
<author><name sortKey="Onaka, H" uniqKey="Onaka H">H. Onaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stein, T" uniqKey="Stein T">T. Stein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Strobel, G A" uniqKey="Strobel G">G. A. Strobel</name>
</author>
<author><name sortKey="Daisy, B" uniqKey="Daisy B">B. Daisy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sziderics, A H" uniqKey="Sziderics A">A. H. Sziderics</name>
</author>
<author><name sortKey="Rasche, F" uniqKey="Rasche F">F. Rasche</name>
</author>
<author><name sortKey="Trognitz, F" uniqKey="Trognitz F">F. Trognitz</name>
</author>
<author><name sortKey="Sessitsch, A" uniqKey="Sessitsch A">A. Sessitsch</name>
</author>
<author><name sortKey="Wilhelm, E" uniqKey="Wilhelm E">E. Wilhelm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taechowisan, T" uniqKey="Taechowisan T">T. Taechowisan</name>
</author>
<author><name sortKey="Chaisaeng, S" uniqKey="Chaisaeng S">S. Chaisaeng</name>
</author>
<author><name sortKey="Phutdhawong, W S" uniqKey="Phutdhawong W">W. S. Phutdhawong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taechowisan, T" uniqKey="Taechowisan T">T. Taechowisan</name>
</author>
<author><name sortKey="Chanaphat, S" uniqKey="Chanaphat S">S. Chanaphat</name>
</author>
<author><name sortKey="Ruensamran, W" uniqKey="Ruensamran W">W. Ruensamran</name>
</author>
<author><name sortKey="Phutdhawong, W S" uniqKey="Phutdhawong W">W. S. Phutdhawong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taechowisan, T C" uniqKey="Taechowisan T">T. C. Taechowisan</name>
</author>
<author><name sortKey="Lu, C H" uniqKey="Lu C">C. H. Lu</name>
</author>
<author><name sortKey="Shen, Y M" uniqKey="Shen Y">Y. M. Shen</name>
</author>
<author><name sortKey="Lumyong, S" uniqKey="Lumyong S">S. Lumyong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamosiune, I" uniqKey="Tamosiune I">I. Tamosiune</name>
</author>
<author><name sortKey="Baniulis, D" uniqKey="Baniulis D">D. Baniulis</name>
</author>
<author><name sortKey="Stanys, V" uniqKey="Stanys V">V. Stanys</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tian, B" uniqKey="Tian B">B. Tian</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name>
</author>
<author><name sortKey="Ye, Y" uniqKey="Ye Y">Y. Ye</name>
</author>
<author><name sortKey="Wen, J" uniqKey="Wen J">J. Wen</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tripathi, V C" uniqKey="Tripathi V">V. C. Tripathi</name>
</author>
<author><name sortKey="Satish, S" uniqKey="Satish S">S. Satish</name>
</author>
<author><name sortKey="Horam, S" uniqKey="Horam S">S. Horam</name>
</author>
<author><name sortKey="Raj, S" uniqKey="Raj S">S. Raj</name>
</author>
<author><name sortKey="Arockiaraj, J" uniqKey="Arockiaraj J">J. Arockiaraj</name>
</author>
<author><name sortKey="Pasupuleti, M" uniqKey="Pasupuleti M">M. Pasupuleti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsurumaru, H" uniqKey="Tsurumaru H">H. Tsurumaru</name>
</author>
<author><name sortKey="Okubo, T" uniqKey="Okubo T">T. Okubo</name>
</author>
<author><name sortKey="Okazaki, K" uniqKey="Okazaki K">K. Okazaki</name>
</author>
<author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M. Hashimoto</name>
</author>
<author><name sortKey="Kakizaki, K" uniqKey="Kakizaki K">K. Kakizaki</name>
</author>
<author><name sortKey="Hanzawa, E" uniqKey="Hanzawa E">E. Hanzawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verma, P" uniqKey="Verma P">P. Verma</name>
</author>
<author><name sortKey="Yadav, A N" uniqKey="Yadav A">A. N. Yadav</name>
</author>
<author><name sortKey="Khannam, K S" uniqKey="Khannam K">K. S. Khannam</name>
</author>
<author><name sortKey="Panjiar, N" uniqKey="Panjiar N">N. Panjiar</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name>
</author>
<author><name sortKey="Saxena, A K" uniqKey="Saxena A">A. K. Saxena</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verma, V C" uniqKey="Verma V">V. C. Verma</name>
</author>
<author><name sortKey="Gond, S K" uniqKey="Gond S">S. K. Gond</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name>
</author>
<author><name sortKey="Mishra, A" uniqKey="Mishra A">A. Mishra</name>
</author>
<author><name sortKey="Kharwar, R N" uniqKey="Kharwar R">R. N. Kharwar</name>
</author>
<author><name sortKey="Gange, A C" uniqKey="Gange A">A. C. Gange</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Villarreal Delgado, M F" uniqKey="Villarreal Delgado M">M. F. Villarreal-Delgado</name>
</author>
<author><name sortKey="Villa Rodriguez, E D" uniqKey="Villa Rodriguez E">E. D. Villa-Rodríguez</name>
</author>
<author><name sortKey="Cira Chavez, L A" uniqKey="Cira Chavez L">L. A. Cira-Chávez</name>
</author>
<author><name sortKey="Estrada Alvarado, M I" uniqKey="Estrada Alvarado M">M. I Estrada-Alvarado</name>
</author>
<author><name sortKey="Parra Cota, F I" uniqKey="Parra Cota F">F. I. Parra-Cota</name>
</author>
<author><name sortKey="De Los Santos Villalobos, S" uniqKey="De Los Santos Villalobos S">S. de los Santos-Villalobos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vu, H N T" uniqKey="Vu H">H. N. T. Vu</name>
</author>
<author><name sortKey="Nguyen, D T" uniqKey="Nguyen D">D. T. Nguyen</name>
</author>
<author><name sortKey="Nguyen, H Q" uniqKey="Nguyen H">H. Q. Nguyen</name>
</author>
<author><name sortKey="Chu, H H" uniqKey="Chu H">H. H. Chu</name>
</author>
<author><name sortKey="Chu, S K" uniqKey="Chu S">S. K. Chu</name>
</author>
<author><name sortKey="Van Chau, M" uniqKey="Van Chau M">M. Van Chau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waring, M J" uniqKey="Waring M">M. J. Waring</name>
</author>
<author><name sortKey="Wakelin, L P" uniqKey="Wakelin L">L. P. Wakelin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, W" uniqKey="Wei W">W. Wei</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name>
</author>
<author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name>
</author>
<author><name sortKey="Yan, X" uniqKey="Yan X">X. Yan</name>
</author>
<author><name sortKey="Lai, Y" uniqKey="Lai Y">Y. Lai</name>
</author>
<author><name sortKey="Wei, C" uniqKey="Wei C">C. Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xia, Y" uniqKey="Xia Y">Y. Xia</name>
</author>
<author><name sortKey="Debolt, S" uniqKey="Debolt S">S. DeBolt</name>
</author>
<author><name sortKey="Dreyer, J" uniqKey="Dreyer J">J. Dreyer</name>
</author>
<author><name sortKey="Scott, D" uniqKey="Scott D">D. Scott</name>
</author>
<author><name sortKey="Williams, M A" uniqKey="Williams M">M. A. Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yuan, J" uniqKey="Yuan J">J. Yuan</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name>
</author>
<author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name>
</author>
<author><name sortKey="Wen, T" uniqKey="Wen T">T. Wen</name>
</author>
<author><name sortKey="Huang, Q" uniqKey="Huang Q">Q. Huang</name>
</author>
<author><name sortKey="Shen, Q" uniqKey="Shen Q">Q. Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeiller, M" uniqKey="Zeiller M">M. Zeiller</name>
</author>
<author><name sortKey="Rothballer, M" uniqKey="Rothballer M">M. Rothballer</name>
</author>
<author><name sortKey="Iwobi, A N" uniqKey="Iwobi A">A. N. Iwobi</name>
</author>
<author><name sortKey="Bohnel, H" uniqKey="Bohnel H">H. Böhnel</name>
</author>
<author><name sortKey="Gessler, F" uniqKey="Gessler F">F. Gessler</name>
</author>
<author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A. Hartmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, K" uniqKey="Zhao K">K. Zhao</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name>
</author>
<author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name>
</author>
<author><name sortKey="Ao, X" uniqKey="Ao X">X. Ao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, K" uniqKey="Zhao K">K. Zhao</name>
</author>
<author><name sortKey="Penttinen, P" uniqKey="Penttinen P">P. Penttinen</name>
</author>
<author><name sortKey="Guan, T" uniqKey="Guan T">T. Guan</name>
</author>
<author><name sortKey="Xiao, J" uniqKey="Xiao J">J. Xiao</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, P J" uniqKey="Zhao P">P. J. Zhao</name>
</author>
<author><name sortKey="Fan, L M" uniqKey="Fan L">L. M. Fan</name>
</author>
<author><name sortKey="Li, G H" uniqKey="Li G">G. H. Li</name>
</author>
<author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name>
</author>
<author><name sortKey="Shen, Y M" uniqKey="Shen Y">Y. M. Shen</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Microbiol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Microbiol.</journal-id>
<journal-title-group><journal-title>Frontiers in Microbiology</journal-title>
</journal-title-group>
<issn pub-type="epub">1664-302X</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30984118</article-id>
<article-id pub-id-type="pmc">6449470</article-id>
<article-id pub-id-type="doi">10.3389/fmicb.2019.00463</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject>
<subj-group><subject>Mini Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Bioactive Products From Plant-Endophytic Gram-Positive Bacteria</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ek-Ramos</surname>
<given-names>María J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/359805/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Gomez-Flores</surname>
<given-names>Ricardo</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Orozco-Flores</surname>
<given-names>Alonso A.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/695806/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Rodríguez-Padilla</surname>
<given-names>Cristina</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>González-Ochoa</surname>
<given-names>Guadalupe</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/695794/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Tamez-Guerra</surname>
<given-names>Patricia</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/534040/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León</institution>
,<addr-line>San Nicolás de los Garza</addr-line>
,<country>Mexico</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Departamento de Ciencias Químico Biológicas, División de Ciencias e Ingeniería, Universidad de Sonora</institution>
,<addr-line>Navojoa</addr-line>
,<country>Mexico</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: José E. Barboza-Corona, Universidad de Guanajuato, Mexico</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Ashutosh Sharma, Tecnologico de Monterrey, Mexico; Tapan Kumar Adhya, KIIT University, India</p>
</fn>
<corresp id="c001">*Correspondence: Patricia Tamez-Guerra, <email>patamez@hotmail.com</email>
; <email>patricia.tamezgr@uanl.edu.mx</email>
</corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Microbiotechnology, Ecotoxicology and Bioremediation, a section of the journal Frontiers in Microbiology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>29</day>
<month>3</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>10</volume>
<elocation-id>463</elocation-id>
<history><date date-type="received"><day>29</day>
<month>10</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>21</day>
<month>2</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2019 Ek-Ramos, Gomez-Flores, Orozco-Flores, Rodríguez-Padilla, González-Ochoa and Tamez-Guerra.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Ek-Ramos, Gomez-Flores, Orozco-Flores, Rodríguez-Padilla, González-Ochoa and Tamez-Guerra</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Endophytes constitute plant-colonizing microorganisms in a mutualistic symbiosis relationship. They are found in most ecosystems reducing plant crops’ biotic and abiotic stressors by stimulating immune responses, excluding plant pathogens by niche competition, and participating in antioxidant activities and phenylpropanoid metabolism, whose activation produces plant defense, structural support, and survival molecules. In fact, metabolomic studies have demonstrated that endophyte genes associated to specific metabolites are involved in plant growth promotion (PGP) by stimulating plant hormones production such as auxins and gibberellins or as plant protective agents against microbial pathogens, cancer, and insect pests, but eco-friendly and eco-safe. A number of metabolites of Gram-positive endophytes isolated from agriculture, forest, mangrove, and medicinal plants, mainly related to the Firmicutes phyla, possess distinctive biocontrol and plant growth-promoting activities. In general, Actinobacteria and <italic>Bacillus</italic>
endophytes produce aromatic compounds, lipopeptides, plant hormones, polysaccharides, and several enzymes linked to phenylpropanoid metabolism, thus representing high potential for PGP and crop management strategies. Furthermore, Actinobacteria have been shown to produce metabolites with antimicrobial and antitumor activities, useful in agriculture, medicine, and veterinary areas. The great endophytes diversity, their metabolites production, and their adaptation to stress conditions make them a suitable and unlimited source of novel metabolites, whose application could reduce agrochemicals usage in food and drugs production.</p>
</abstract>
<kwd-group><kwd>metabolites</kwd>
<kwd>amylases</kwd>
<kwd>chitinases</kwd>
<kwd>endoglucanases</kwd>
<kwd>esterases</kwd>
<kwd>proteases</kwd>
<kwd>plant hormones</kwd>
<kwd>toxins</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">Consejo Nacional de Ciencia y Tecnología<named-content content-type="fundref-id">10.13039/501100007350</named-content>
</funding-source>
</award-group>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="0"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="128"></ref-count>
<page-count count="12"></page-count>
<word-count count="0"></word-count>
</counts>
</article-meta>
</front>
<body><sec><title>Introduction to Endophytes</title>
<p>Endophytes are facultative or obligate symbiotic microorganisms, mainly bacterial and fungal species, that live in apparently healthy internal plant tissues, without causing disease (<xref rid="B102" ref-type="bibr">Schulz and Boyle</xref>
, <xref rid="B102" ref-type="bibr">2006</xref>
). The most studied ones are bacterial and fungal species.</p>
<p>The purpose of this minireview is to highlight the importance of previously reported endophytic Gram-positive bacteria bioactive products. The International Union for Conservation of Nature and Natural Resources estimates that there are about 297,326 species of plants (Monocotyledons, Dicotyledons, Gymnosperms, Ferns and allies and Mosses), but only a few of them have been studied for their endophyte microbiota (<xref rid="B108" ref-type="bibr">Strobel and Daisy, 2003</xref>
; <xref rid="B1" ref-type="bibr">Aitken, 2004</xref>
). Endophytic microorganisms are known to influence plant physiology and development, among which, Gram-positive bacteria are important in such activities as bioremediation, biocontrol, plant growth, symbiotic-mutualistic, commensalistic, trophobiotic interactions, control of soil-borne pathogens, and support of host plant defense against environmental stress (<xref rid="B98" ref-type="bibr">Ryan et al., 2008</xref>
). An endophytic community is complex and several factors may affect its structure, such as plant-microbe and microbe-microbe interactions and environmental conditions (<xref rid="B98" ref-type="bibr">Ryan et al., 2008</xref>
). For bacterial endophytes diversity analysis, cultivation-based and culture-independent methods are used. In regard to cultivation studies, a great number of bacteria, mostly Proteobacteria, have been reported as endophytes, being the most frequent from Actinobacteria, Bacteroidetes, and Firmicutes phyla (<xref rid="B97" ref-type="bibr">Rosenblueth and Martínez-Romero, 2006</xref>
).</p>
<p>The most abundant metabolite producing Gram-positive bacteria endophytes found within diverse environments are <italic>Bacillus</italic>
and <italic>Streptomyces</italic>
species (<xref rid="B95" ref-type="bibr">Reinhold-Hurek and Hurek, 2011</xref>
; <xref rid="B42" ref-type="bibr">Frank et al., 2017</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
–<xref ref-type="fig" rid="F3">3</xref>
).</p>
<fig id="F1" position="float"><label>FIGURE 1</label>
<caption><p>Production of metabolites by endophytes among plant tissues. <sup>1</sup>
The “ESKAPE” bacterial pathogens (<italic>Acinetobacter baumannii, Enterobacter</italic>
spp., <italic>Enterococcus faecium, Klebsiella pneumoniae, Pseudomonas aeruginosa</italic>
, and <italic>Staphylococcus aureus</italic>
) are the leading nosocomial infectious agents throughout the world. <sup>2</sup>
Metabolites synthesized by non-ribosomal peptide synthetases (NRPS) or polyketide synthase (PKS). Detailed information on antimicrobial metabolites against animal/human pathogens are in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
, against plant pathogens and insect pests in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S2</xref>
, as plant growth stimulant in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S3</xref>
and as anti-cancer agent in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
.</p>
</caption>
<graphic xlink:href="fmicb-10-00463-g001"></graphic>
</fig>
<fig id="F2" position="float"><label>FIGURE 2</label>
<caption><p>Production of metabolites by <italic>Bacillus</italic>
spp. and strains as plant endophytes. (a) <italic>Bacillus amyloliquefaciens</italic>
; (b) <italic>Bacillus subtilis</italic>
. <sup>1</sup>
PGP, plant growth promoting. <sup>2</sup>
Metabolites synthesized by NRPS or PKS. <sup>3</sup>
IAA, indol acetic acid. Detailed information on antimicrobial metabolites against animal/human pathogens are in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
, against plant pathogens and insect pests in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S2</xref>
, as plant growth stimulant in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S3</xref>
and as anti-cancer agent in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
.</p>
</caption>
<graphic xlink:href="fmicb-10-00463-g002"></graphic>
</fig>
<fig id="F3" position="float"><label>FIGURE 3</label>
<caption><p>Production of metabolites by <italic>Streptomyces</italic>
spp. and strains as plant endophytes. (a) Antimicrobial metabolites against human pathogens; (b) metabolites showing antimicrobial and cytotoxic activity; (c) cytotoxic metabolites against several tumor cell lines. <sup>1</sup>
PGP, plant growth promote. Detailed information on antimicrobial metabolites against animal/human pathogens are in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
, against plant pathogens and insect pests in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S2</xref>
, as plant growth stimulant in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S3</xref>
and as anti-cancer agent in <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
.</p>
</caption>
<graphic xlink:href="fmicb-10-00463-g003"></graphic>
</fig>
<p>Endophytes are found in plants of most ecosystems and are of agricultural importance since they help to improve crops yields, by stimulating plants growth and immune response, excluding plant pathogens by niche competition, as well as actively participating in phenylpropanoid metabolism and antioxidant activities (<xref rid="B85" ref-type="bibr">Pandey et al., 2018</xref>
). Among plant microbiota, endophytic bacteria can be found in most plant species and be recovered from roots, leaves, stems, and a few from flowers, fruits, and seeds (<xref rid="B74" ref-type="bibr">Lodewyckx et al., 2002</xref>
); they have the potential to produce a variety of secondary metabolites with application in agriculture and pharmaceutical and industrial biotechnology (<xref rid="B74" ref-type="bibr">Lodewyckx et al., 2002</xref>
; <xref rid="B108" ref-type="bibr">Strobel and Daisy, 2003</xref>
; <xref rid="B98" ref-type="bibr">Ryan et al., 2008</xref>
). Bacterial endophytes live within cell walls and xylem vessels intercellular regions and they may colonize seeds (<xref rid="B13" ref-type="bibr">Cankar et al., 2005</xref>
; <xref rid="B64" ref-type="bibr">Johnston-Monje and Raizada, 2011</xref>
), fruits (<xref rid="B30" ref-type="bibr">de Melo-Pereira et al., 2012</xref>
), and flowers (<xref rid="B27" ref-type="bibr">Compant et al., 2011</xref>
), among other tissues. It is known that endophytic bacteria are located in the apoplast (<xref rid="B70" ref-type="bibr">Koskimäki et al., 2015</xref>
), and plant roots are proposed to be the entry point (<xref rid="B86" ref-type="bibr">Paungfoo-Lonhienne et al., 2010</xref>
). It is also suggested that they are transmitted using an alternative vertical strategy due to their presence in flowers and seeds (<xref rid="B113" ref-type="bibr">Tamosiune et al., 2017</xref>
). The potential explanation for their ubiquitous presence into plant tissues is the diversity of positive effects on plant growth and fitness they have shown, by stimulating the host phenylpropanoid pathway or by producing several linked-metabolites to the plants’ metabolism (<xref rid="B11" ref-type="bibr">Brader et al., 2014</xref>
; <xref rid="B54" ref-type="bibr">Haidar et al., 2016</xref>
; <xref rid="B75" ref-type="bibr">Lòpez-Fernàndez et al., 2016</xref>
; <xref rid="B3" ref-type="bibr">Alaimo et al., 2018</xref>
). Many reports indicate that bacterial endophytes help to provide nutrients as plant growth-promoters, and induce tolerance/resistance against biotic and abiotic stress conditions (<xref rid="B98" ref-type="bibr">Ryan et al., 2008</xref>
).</p>
<p>In addition, several metabolites produced by microbial endophytes act as antimicrobial agents against human, animal, and plant pathogens. Whereas the antimicrobial effect against phytopathogens will have the positive effect on the host plant, the efficacies of endophyte metabolites may show a great clinical potential for medical and veterinary treatments. Indeed, nature-occurring antibiotics are low-molecular-weight products made by microbes that inhibit the growth or kill phytopathogens, bacteria, fungi, viruses, and protozoans, that cause human and animal diseases (<xref rid="B31" ref-type="bibr">Demain, 1981</xref>
; <xref rid="B62" ref-type="bibr">Jakubiec-Krzesniak et al., 2018</xref>
; <xref rid="B115" ref-type="bibr">Tripathi et al., 2018</xref>
). Some important antibiotics producers have been recently found as endophytes in different plant species (<xref rid="B37" ref-type="bibr">Eljounaidi et al., 2016</xref>
).</p>
<p>It is known that immunocompromised individuals (AIDS, cancer, and organ transplant patients) are at high risk for developing opportunistic microbial infections by <italic>Aspergillus</italic>
sp., <italic>Candida albicans, Clostridium difficile, Coccidioides immitis, Cryptococcus neoformans, Cryptosporidium, Mycobacterium avium</italic>
complex, <italic>M. tuberculosis, Pneumocystis jirovecii, Pseudomonas aeruginosa, Salmonella</italic>
sp., <italic>Staphylococcus aureus, Streptococcus pneumoniae</italic>
, and <italic>S. pyogenes</italic>
, as well as parasitic infections caused by <italic>Cryptosporidium</italic>
spp., <italic>Encephalitozoon</italic>
spp., <italic>Isospora belli, Leishmania</italic>
spp., <italic>Plasmodium falciparum, Toxoplasma gondii</italic>
, and <italic>Trypanosoma cruzi</italic>
. The urgent need for human diseases prevention and treatment, has promoted the discovery and development of novel and efficient therapeutic agents to which resistance has not been produced (<xref rid="B108" ref-type="bibr">Strobel and Daisy, 2003</xref>
; <xref rid="B25" ref-type="bibr">Chinedum, 2005</xref>
). For instance, drug resistance is a recognized phenomenon that disease-causing microbial agents develop against pharmaceutical therapy. Infectious diseases and cancer share similarities in the mechanisms of resistance to drugs, such as drug efflux, which is evolutionarily conserved (<xref rid="B55" ref-type="bibr">Housman et al., 2014</xref>
). Therefore, in this review, the antibacterial, antifungal, antiviral, and antitumor activities of metabolites produced by specific Gram-positive bacteria endophytes are highlighted, as well as their potential use as plant growth promoters (PGP).</p>
</sec>
<sec><title>Gram-Positive Endophytes Against Human/Animal Pathogens</title>
<p>Among Actinobacteria, Actinomycetes are Gram-positive, filamentous bacteria with great potential as biocontrol agents, which produce approximately two-thirds of natural antibiotics, where 75% derived from <italic>Streptomyces</italic>
species (<xref rid="B29" ref-type="bibr">de Lima Procópio et al., 2012</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3</xref>
). Actinomycetes, including the <italic>Actinomyces, Actinoplanes, Amycolatopsis, Micromonospora, Saccharopolyspora</italic>
, and <italic>Streptomyces</italic>
genera, are recognized as bioactive secondary metabolites producers, not only showing antimicrobial, but also insecticidal and antitumoral activities (<xref rid="B96" ref-type="bibr">Renu et al., 2008</xref>
; <xref rid="B67" ref-type="bibr">Kekuda et al., 2010</xref>
).</p>
<p>Lipopeptides are among the most important classes of secondary metabolites produced by endophytic bacteria, which are formed by cyclic or short linear peptides linked to a lipid tail or lipophilic molecules. Lipopeptides may show antimicrobial, cytotoxic and surfactant activities; they are synthesized by non-ribosomal peptide synthetases (NRPS), or polyketide synthase (PKS) and have great structural diversity based on a hydrophobic fatty acid acyl chain of 13 to 17 carbons, linked to a hydrophilic peptide of 7–25 aminoacids. Lipopeptides are important for both, their antibiotic activity and for inducing plant defense mechanisms (<xref rid="B107" ref-type="bibr">Stein, 2005</xref>
; <xref rid="B92" ref-type="bibr">Raaijmakers et al., 2010</xref>
). One bacterial strain may synthesize several polypeptide isoforms. <italic>Bacillus</italic>
and <italic>Paenibacillus</italic>
-related lipopeptides are the most studied ones (<xref rid="B119" ref-type="bibr">Villarreal-Delgado et al., 2018</xref>
), whereas several <italic>Bacillus amyloliquefaciens</italic>
strains have been recognized as higher lipopeptides producers (<xref ref-type="fig" rid="F2">Figure 2A</xref>
; <xref rid="B84" ref-type="bibr">Ongena and Jacques, 2008</xref>
). In addition to lipopeptides, <italic>B. subtilis</italic>
produces NRPS lantibiotics (lanthionine-containing antibiotics) (<xref rid="B107" ref-type="bibr">Stein, 2005</xref>
); lipopeptides are responsible for biofilm and swarming development, whereas lantibiotics play as pheromones in quorum-sensing (<xref rid="B107" ref-type="bibr">Stein, 2005</xref>
). <italic>B. subtilis</italic>
also produces compounds such as polyketides, an aminosugar, and a phospholipid; polyketides include bacillomycin, fengycin, iturin, lichenysin, mycosubtilin, plipastatin, pumilacidin, and surfactin (<xref ref-type="fig" rid="F2">Figure 2B</xref>
); whereas <italic>Paenibacillus polymyxa</italic>
synthesizes polymyxins (cyclic cationic lipopeptides) (<xref rid="B107" ref-type="bibr">Stein, 2005</xref>
; <xref rid="B51" ref-type="bibr">Grady et al., 2016</xref>
; <xref ref-type="supplementary-material" rid="SM1">Supplementary Tables S1</xref>
–<xref ref-type="supplementary-material" rid="SM1">S4</xref>
).</p>
<p>In addition to biologically active secondary metabolites, bacterial endophytes also produce important antimicrobial enzymes, mainly by Bacilli class members (<xref ref-type="fig" rid="F2">Figure 2</xref>
). In a study looking for highly producing enzymes endophytes, in the mangrove in Thailand, <xref rid="B68" ref-type="bibr">Khianngam et al. (2013)</xref>
found that Gram-positive bacteria showed more hydrolytic activity compared with that of Gram-negative ones. Testing endophytes in hosts from the Rhizophoraceae family, results showed amylase, cellulase, and lipase activity by <italic>B. infantis</italic>
and <italic>B. granadenis</italic>
; and amylase, cellulase, lipase, lipolytic and proteinase activity by <italic>B. safensis</italic>
. Similarly, cellulase, lipase, and proteinase activities by <italic>Paenibacillus</italic>
sp. and <italic>S. warneri</italic>
were detected in Acanthaceae family endophytes. Endophytes isolated from Brazilian mangrove plants showed high enzymatic activity; among these isolates, <italic>Bacillus</italic>
sp. (MCR2.56) was reported to show particularly high amylase and esterasic activities; six <italic>Bacillus</italic>
isolates (MCR2.51, MCA2.42, MCA2.51, MBR2.4, MBA2.33, and MBA2.4) high endocellulolytic activity, whereas the actinobacteria <italic>Microbacterium</italic>
sp. (MCA2.54) and <italic>Curtobacterium</italic>
sp. (MBR2.20) showed high endoglucanase and protease activity, respectively (<xref rid="B19" ref-type="bibr">Castro et al., 2014</xref>
; <xref ref-type="fig" rid="F2">Figure 2</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Tables S1</xref>
–<xref ref-type="supplementary-material" rid="SM1">S3</xref>
).</p>
<p>Bioactive endophytic Streptomycetes can be isolated from plants worldwide (<xref rid="B16" ref-type="bibr">Castillo et al., 2007</xref>
; <xref ref-type="fig" rid="F3">Figure 3</xref>
). Medicinal plants have been used for centuries as an alternative therapy for disease treatment. Interestingly, Chinese medicinal plants-endophytic actinomycetes were reported to have antibacterial activity against <italic>E. coli</italic>
and <italic>S. aureus</italic>
(<xref rid="B127" ref-type="bibr">Zhao et al., 2011</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
). Recently, endophytic actinomycetes were reported in several Chinese mangrove plants to exhibit antibacterial activity against <italic>Acinetobacter baumannii, Enterococcus faecali</italic>
s, <italic>E. coli, Klebsiella pneumoniae, P. aeruginosa</italic>
, and <italic>S. aureus</italic>
, some of which are resistant to the vancomycin, methicillin, and carbapenem antibiotics (<xref rid="B63" ref-type="bibr">Jiang et al., 2018</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3</xref>
). Several metabolites from endophytic <italic>Streptomyces</italic>
species have been characterized and associated with antibiotic activity, including kakadumycins, munumbicins, <italic>p</italic>
-aminoacetophenonic acids, and xiamycins (<xref rid="B17" ref-type="bibr">Castillo et al., 2002</xref>
, <xref rid="B15" ref-type="bibr">2003</xref>
; <xref rid="B52" ref-type="bibr">Guan et al., 2005</xref>
); antimalarial (coronamycin, munumbicin D) (<xref rid="B17" ref-type="bibr">Castillo et al., 2002</xref>
; <xref rid="B39" ref-type="bibr">Ezra et al., 2004</xref>
); and antifungal (munumbicin D) (<xref rid="B106" ref-type="bibr">Shimizu et al., 2000</xref>
; <xref rid="B39" ref-type="bibr">Ezra et al., 2004</xref>
) activities (<xref ref-type="fig" rid="F3">Figure 3</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
). Similarly, Iranian medicinal plants-endophytic actinomyctes exhibited antimicrobial activity against the pathogenic bacteria <italic>B. cereus, B. subtilis, E. coli, Citrobacter freundii, K</italic>
. <italic>pneumoniae, Proteus mirabilis, Shigella flexneri</italic>
, and <italic>S. aureus</italic>
(<xref rid="B8" ref-type="bibr">Beiranvand et al., 2017</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3</xref>
), whereas Malaysian plants-endophytic <italic>B. subtilis</italic>
possessed antibacterial activity against <italic>S. aureus</italic>
, methicillin resistant <italic>S. aureus</italic>
, and <italic>P. aeruginosa</italic>
(<xref rid="B41" ref-type="bibr">Fikri et al., 2018</xref>
; <xref ref-type="fig" rid="F2">Figure 2B</xref>
). The African <italic>Combretum molle</italic>
-endophytic <italic>Bacillus</italic>
and <italic>Lysinibacillus</italic>
species exhibited antibacterial activity against <italic>B. cereus, E. coli, P. aeruginosa</italic>
, and <italic>S. aureus</italic>
(<xref rid="B33" ref-type="bibr">Diale et al., 2018</xref>
; <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
).</p>
<p><italic>Kennedia nigriscans</italic>
-endophytic <italic>Streptomyces</italic>
sp. strain NRRL 30562 produces munumbicins A, B, C, and D, active against growth of <italic>B. anthracis, E. faecalis</italic>
, vancomycin-resistant <italic>E. faecalis</italic>
, multiple-drug-resistant (MDR) <italic>M. tuberculosis, S. pneumoniae, S. aureus</italic>
, and methicillin-resistant <italic>S. aureus</italic>
; furthermore, munumbicins have been shown to be more effective than chloroquine to kill the malaria-causing agent <italic>P. falciparum</italic>
(<xref rid="B17" ref-type="bibr">Castillo et al., 2002</xref>
, <xref rid="B18" ref-type="bibr">2006</xref>
; <xref rid="B26" ref-type="bibr">Christina et al., 2013</xref>
; <xref ref-type="fig" rid="F3">Figure 3A</xref>
). Similarly, kakadumycins have antibacterial and antimalarial activities comparable with those of munumbicins (<xref rid="B121" ref-type="bibr">Waring and Wakelin, 1974</xref>
; <xref rid="B66" ref-type="bibr">Katagiri et al., 1975</xref>
; <xref rid="B15" ref-type="bibr">Castillo et al., 2003</xref>
; <xref ref-type="fig" rid="F3">Figure 3A</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
).</p>
<p><italic>Streptomyces</italic>
sp. strain SUK06, isolated from the Malasian medicinal plant <italic>Thottea grandiflora</italic>
, commonly used as an alternative mean to heal wounds and treat skin infections and fever, produces secondary antimicrobial metabolites against <italic>B. cereus, B. subtilis, Plesiomonas shigelloides, P. aeruginosa</italic>
, and methicillin-resistant <italic>S. aureus</italic>
(<xref rid="B46" ref-type="bibr">Ghadin et al., 2008</xref>
). Similarly, metabolites and cell wall-degrading enzymes from <italic>Panax ginseng</italic>
- and <italic>Plectranthus tenuiflorus</italic>
-endophytic <italic>Bacillus</italic>
sp., <italic>Micrococcus</italic>
sp., and <italic>P. polymyxa</italic>
, were reported to possess antibacterial activity against <italic>E. coli, K. pneumoniae, P. mirabilis, Salmonella enterica</italic>
subsp. <italic>enterica</italic>
serovar Typhi, <italic>S. aureus</italic>
, and <italic>S. agalactiae</italic>
(<xref rid="B36" ref-type="bibr">El-Deeb et al., 2013</xref>
; <xref ref-type="fig" rid="F2">Figure 2</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
).</p>
<p>Secondary metabolites spinosyn A and D, are produced by the soil actinomycete <italic>Saccharopolyspora spinosa</italic>
, highly effective against lepidopteran and dipteran pests, among others, which commercial product named spinosad, has been commercialized for ∼250 countries and adopted in integrated pest management programs worldwide. Furthermore, there are reports of endophytic <italic>Saccharopolyspora</italic>
species, although their potential as bioinsecticide has not yet been elucidated (<xref rid="B91" ref-type="bibr">Qin et al., 2011</xref>
).</p>
<p>There are many medical and agricultural applications for the <italic>Azadirachta indica</italic>
(known as neem) produced compounds (<xref ref-type="fig" rid="F1">Figure 1</xref>
). <italic>Macrococcus caseolyticus</italic>
(ALS-1), a member of the Firmicutes, has been reported to produce free radical scavenging compounds. This strain was isolated from <italic>Aloe vera</italic>
in an effort to cultivate bacterial endophytes that could be related to this plant curative and therapeutic uses (<xref rid="B2" ref-type="bibr">Akinsanya et al., 2015</xref>
). In fact, 80% of the <italic>A. vera</italic>
bacterial endophytes produced 1,1-diphenyl-2-picrylhydrazyl, showing over 75% scavenging properties. The <italic>Raphanus sativus</italic>
(young radish) leaf and root endophytic <italic>B. subtilis, Sphingobacterium siyangensis</italic>
, and <italic>P. polymyxa</italic>
were shown to inhibit the growth of <italic>B. cereus, E. coli, P. aeruginosa</italic>
, and <italic>S. aureus</italic>
, in addition to <italic>Salmonella, Shigella</italic>
, and <italic>Listeria</italic>
species (<xref rid="B72" ref-type="bibr">Liu et al., 2010</xref>
). <italic>Zingiber officinale</italic>
roots-endophytic <italic>Streptomyces</italic>
sp. was shown to possess antimicrobial activity against <italic>B. cereus, B. subtilis</italic>
, and <italic>S. aureus</italic>
(<xref rid="B111" ref-type="bibr">Taechowisan et al., 2013</xref>
; <xref ref-type="fig" rid="F3">Figure 3B</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S1</xref>
).</p>
</sec>
<sec><title>Gram-Positive Endophytes Against Plant Pathogens</title>
<p>Endophytes found in grapevine (<italic>Vitis vinifera</italic>
) may represent one interesting example of a widely studied crop system. Metatranscriptoma analysis of vineyards prokaryotic microbiome confirmed that two out of three main bacterial phyla detected (Actinobacteria and Firmicutes) belonged to the Gram-positive group, thus reflecting bacterial metabolic assessments to become symbionts (either epiphytes or endophytes) and be distributed along plant tissues. This study demonstrated that the abundance and richness balance between beneficial microorganisms was critical for phytopathogens biocontrol and grapevine management, where the microbiota stability relied on environmental physicochemical conditions; being the soil type, geography and climate crucial factors to favor this crop. Moreover, detection of a specific strain reflected its ability to be established under the host microclimatic conditions, where <italic>Bacillus</italic>
spp. were widely spread in flowers, leaves and grapes (<xref rid="B3" ref-type="bibr">Alaimo et al., 2018</xref>
). In addition, <xref rid="B54" ref-type="bibr">Haidar et al. (2016)</xref>
found that <italic>B. pumilus</italic>
conferred systemic resistance against this pathogen, after studying the antagonistic bacteria modes of action for the phytopathogen <italic>Phaeomoniella chlamydospora</italic>
biocontrol in grapevine.</p>
<p>The biological control of plant phytopathogens by endophytes was reported in late 50s where, a <italic>Micromonospora</italic>
isolate from tomato showed antagonistic activity against <italic>Fusarium oxysporum</italic>
f.sp. <italic>lycopersici</italic>
(<xref rid="B78" ref-type="bibr">Manikprabhu and Li, 2016</xref>
). As previously stated, the most abundant Gram-positive bacterial endophytes found within diverse environments are <italic>Bacillus</italic>
and <italic>Streptomyces</italic>
species (<xref rid="B95" ref-type="bibr">Reinhold-Hurek and Hurek, 2011</xref>
; <xref rid="B42" ref-type="bibr">Frank et al., 2017</xref>
), both exhibiting secondary metabolites showing antimicrobial activity also against plant pathogens. In fact, there have been proposed <italic>Bacillus</italic>
spp. endophytes for crop management (<xref rid="B4" ref-type="bibr">Aloo et al., 2018</xref>
; <xref ref-type="fig" rid="F2">Figure 2</xref>
). Similarly, <italic>Streptomyces</italic>
spp. endophytes are widely reported as phytopathogens biocontrol agents (<xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3</xref>
). For example, <italic>K. nigriscans</italic>
-endophytic <italic>Streptomyces</italic>
sp. strain NRRL 30562 were recently reported to produce antibiotics as munumbicins A, B, C, and D, active against plant pathogenic bacteria and fungi (<xref rid="B17" ref-type="bibr">Castillo et al., 2002</xref>
). Leguminose plants-endophytic <italic>Streptomyces caeruleatus</italic>
was reported to be effective against the soybean pathogen <italic>X. campestris</italic>
pv. <italic>glycine</italic>
(<xref rid="B80" ref-type="bibr">Mingma et al., 2014</xref>
; <xref ref-type="fig" rid="F3">Figure 3B</xref>
); whereas metabolites from <italic>A. indica</italic>
- and <italic>Nothofagus</italic>
spp.-endophytic actinomyctes inhibited the plant pathogenic fungi <italic>Mycosphaerella fijiensis, Sclerotinia sclerotiorum</italic>
, and <italic>Rhizoctonia solani</italic>
, and <italic>Pythium</italic>
and <italic>Phytophthora</italic>
species (<xref rid="B16" ref-type="bibr">Castillo et al., 2007</xref>
; <xref rid="B118" ref-type="bibr">Verma et al., 2009</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3B</xref>
). Indeed, <xref rid="B16" ref-type="bibr">Castillo et al. (2007)</xref>
reported <italic>Streptomyces</italic>
spp. endophytic of <italic>Nothofagus</italic>
spp. in southern Patagonia, where the same strain characterized as <italic>Streptomyces seoulensis</italic>
(based on molecular sequenciation and biological activity) was isolated from two different plants (strains coded C2 and C4, respectively); their antifungal activity was then proposed to elucidate the native plants survival mechanisms against plant pathogens within that area (<xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3B</xref>
). Similarly, metabolites produced by roots’ endophytic actinomycetes previously described (<xref rid="B79" ref-type="bibr">Matsumoto and Takahashi, 2017</xref>
), inhibited <italic>Kocuria rhizophila</italic>
strain KB-212, <italic>Mucor racemosus</italic>
strain KF-223, and <italic>Xanthomonas campestris</italic>
pv. <italic>oryzae</italic>
strain KB-88 growth (<xref ref-type="fig" rid="F1">Figure 1</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S2</xref>
).</p>
<p><italic>Zea mays</italic>
seeds-endophytic <italic>B. amyloliquefaciens</italic>
and <italic>B. subtilis</italic>
were observed to inhibit <italic>F. moniliforme</italic>
fungus growth by producing lipopeptides (<xref rid="B49" ref-type="bibr">Gond et al., 2015</xref>
); similarly, <italic>Bruguiera gymnorrhiza</italic>
(L.) Lam-endophytic <italic>B. amyloliquefaciens</italic>
was shown to be antagonistic to various bacterial (<italic>Ralstonia solanacearum, P. syringae</italic>
, and <italic>X. campestris</italic>
), and fungal (<italic>Colletotrichum musae, F. oxysporum, Phytophthora capsici</italic>
, and <italic>R. solani</italic>
) pathogens of plants and to be effective in the biocontrol of <italic>Capsicum</italic>
bacterial wilt in pot and field trials (<xref rid="B56" ref-type="bibr">Hu et al., 2010</xref>
).</p>
<p><italic>Oryza sativa</italic>
-endophytic <italic>B. cereus</italic>
and <italic>B. mojavensis</italic>
were observed to exhibit antimicrobial activity against the fungal rice pathogens <italic>F. fujikuroi, F. proliferum, F. verticillioides, Magnaporthe grisea</italic>
, and <italic>M. salvinii</italic>
(<xref rid="B38" ref-type="bibr">Etesami and Alikhani, 2017</xref>
; <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S2</xref>
).</p>
<p>Young radish-endophytic <italic>B. subtilis, Brachybacterium</italic>
, and <italic>P. polymyxa</italic>
were reported to possess antifungal activity against <italic>F. oxysporum, Pythium ultimum, Phytophthora capsici</italic>
, and <italic>R. solani</italic>
(<xref rid="B104" ref-type="bibr">Seo et al., 2010</xref>
). An antifungal protein from the wheat-endophytic <italic>B. subtilis</italic>
strain EDR4 inhibited <italic>B. cinerea, F. graminearum, F. oxysporum</italic>
f.sp. <italic>vasinfectum, G. graminis</italic>
var. <italic>tritici, Macrophoma kuwatsukai</italic>
, and <italic>R. cerealis</italic>
growth (<xref rid="B72" ref-type="bibr">Liu et al., 2010</xref>
; <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S2</xref>
).</p>
</sec>
<sec><title>Metabolites From Gram-Positive Endophytes as Plant Growth-Promoters</title>
<p>Endophytic bacteria use to protect crops from microbial diseases is relevant, for their potential to promote host growth and antimicrobial activity (<xref rid="B100" ref-type="bibr">Safiyazov et al., 1995</xref>
; <xref rid="B9" ref-type="bibr">Berg et al., 2005</xref>
). Plant growth promotion (PGP) and, in most cases, abiotic stress tolerance and disease protection properties induction, are associated with endophytic bacteria potential to produce different compounds. Plants acclimate to environmental stresses by altering their physiology to be able to overcome stress factors such as dehydration, mechanical injury, nutrient deficiency, high solar radiation, or biotic/abiotic factors. It has been observed that plant inoculation with endophytic bacteria leads to accumulation of “protective” compounds, such as proline, carbohydrates, and antioxidants, in addition to antibiotics and fungal cell-wall lytic enzymes, which can inhibit growth of plant pathogens (<xref rid="B11" ref-type="bibr">Brader et al., 2014</xref>
) or prime plant response to pathogens by induced systemic resistance (ISR) mechanisms (<xref rid="B88" ref-type="bibr">Pieterse et al., 2014</xref>
).</p>
<p>Bacterial endophytes PGP potential is explained through several proposed mechanisms. Several of which help to increase accessibility to nutrients, e.g., nitrogen and phosphorus or metals, or produce metabolites that could regulate plant growth, development and defense responses, such as the well-known phytohormones abscisic acid, auxins, brassinosteroids, cytokinins, ethylene, gibberellins, jasmonates, and strigolactones (<xref rid="B95" ref-type="bibr">Reinhold-Hurek and Hurek, 2011</xref>
; <xref rid="B11" ref-type="bibr">Brader et al., 2014</xref>
; <xref rid="B101" ref-type="bibr">Santoyo et al., 2016</xref>
; <xref rid="B105" ref-type="bibr">Shahzad et al., 2016</xref>
; <xref ref-type="fig" rid="F1">Figure 1</xref>
–<xref ref-type="fig" rid="F3">3</xref>
).</p>
<p>Some examples of Gram-positive PGP bacterial endophytes are <italic>B. pumilus</italic>
strain E2S2, whose treatment increased roots and shoots length and fresh and dry biomass, as compared with untreated sorghum plants, and helped to augment cadmium uptake (<xref rid="B77" ref-type="bibr">Luo et al., 2012</xref>
). <italic>B. amyloliquefaciens</italic>
strain NBRI-SN13 (SN13) isolated from an alkaline soil of Banthara, Lucknow, India, showed several PGP attributes and to induce solubilization of tricalcium phosphate more efficiently, when inoculated as endophyte (<xref rid="B82" ref-type="bibr">Nautiyal et al., 2013</xref>
; <xref ref-type="fig" rid="F2">Figure 2A</xref>
). Plants treated with <italic>B. atrophaeus</italic>
strain EY6, <italic>B. sphaericus</italic>
GC subgroup B EY30, <italic>B. subtilis</italic>
strain EY2, <italic>S. kloosii</italic>
strain EY37 and <italic>K. erythromyxa</italic>
strain EY43 as endophytes, have been shown to increase strawberry fruit growth and yield (<xref rid="B65" ref-type="bibr">Karlidag et al., 2011</xref>
; <xref ref-type="fig" rid="F2">Figure 2</xref>
).</p>
<p>Interestingly, <italic>C. botulinum</italic>
strain 2301 has been shown to have a significant PGP effect on clover in field experiments (<xref rid="B125" ref-type="bibr">Zeiller et al., 2015</xref>
); whereas <italic>Exiguobacterium acetylicum</italic>
1P strain MTCC 8707, a cold tolerant bacterial strain from the Uttarakhand Himalayas, promotes wheat seedlings growth (<xref rid="B103" ref-type="bibr">Selvakumar et al., 2010</xref>
; <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S3</xref>
).</p>
<p><italic>Brevibacillus</italic>
brevis strain SVC(II)14 exerted beneficial PGP on cotton crop (<xref rid="B83" ref-type="bibr">Nehra et al., 2016</xref>
). <italic>Bacillus</italic>
spp. strains CPMO6 and BM17, actinobacteria isolates ACT01 and ACT07, and lactic acid bacteria strain BL06 induce phosphate solubilization more efficiently when present as endophytes in citrus (<xref rid="B47" ref-type="bibr">Giassi et al., 2016</xref>
).</p>
<p>In recent years, it has also been demonstrated that the entomopathogenic bacteria <italic>B. thuringiensis</italic>
can have PGP attributes. <xref rid="B5" ref-type="bibr">Armada et al. (2016)</xref>
tested an autochthonous isolate in interaction with native arbuscular mycorrhizal fungi (single or mixture) and found stimulating plant growth, nutrition and drought tolerance responses.</p>
<p>Siderophores production by endophytes improves plant growth by binding to available iron, competing for this element with phytopathogens and protecting the host plant from their infection (<xref ref-type="fig" rid="F2">Figure 2</xref>
, <xref ref-type="fig" rid="F3">3</xref>
; <xref rid="B99" ref-type="bibr">Sabaté et al., 2018</xref>
). <italic>B. subtilis</italic>
strain B26 has been shown to induce drought tolerance in <italic>Brachypodium distachyon</italic>
grass. This was correlated to augmentation of starch, fructose, glucose and total soluble carbohydrates content. However, increase of raffinose-related family carbohydrates (well-known stress response metabolites) was not observed in control and treated plants (<xref rid="B43" ref-type="bibr">Gagné-Bourque et al., 2015</xref>
). A proline accumulation stimulating effect by endophytic strains of the actinobacteria <italic>Arthrobacter</italic>
sp. and the Firmicutes <italic>Bacillus</italic>
spp. were reported in pepper (<italic>Capsicum annuum</italic>
L., Solanales: Solanaceae) plants <italic>in vitro</italic>
, where their synthesis was related to osmotic stress responses (<xref rid="B109" ref-type="bibr">Sziderics et al., 2007</xref>
). In addition, plants inoculated with bacterial endophytes, could tolerate abiotic stresses by increasing enzymatic activity. <italic>B. cereus</italic>
strain CSR-B-1, <italic>B. marisflavi</italic>
strain CSR-G-4, <italic>B. pumilus</italic>
strain CSR-B-2, <italic>B. saffensis</italic>
strain CSR-G-5, <italic>B. subtilis</italic>
strain CSR-G-1, and <italic>B. thuringiensis</italic>
strain CSRB-3, induced increment of superoxide dismutase, phenylalanine lyase, catalase, and peroxidase enzymes activity in gladiolus plants under sodium high concentration conditions (<xref rid="B28" ref-type="bibr">Damodaran et al., 2014</xref>
; <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S3</xref>
).</p>
<p>Tolerance to low temperatures and growth promotion by endophytic activity has been reported as well. <xref rid="B117" ref-type="bibr">Verma et al. (2015)</xref>
, found <italic>Bacillus</italic>
and <italic>Bacillus</italic>
derived genera as wheat (<italic>Triticum aestivum</italic>
) endophytes from the northern hills zone of India, among others. Phosphate and potassium are major essential macronutrients, but soluble phosphate and potassium concentrations in soil for plant intake are usually very low. Plants need zinc at low concentration since it is toxic at high concentration, thus zinc solubilization by endophytes dosifies the plant intake amount in response to plant and microbial nutritional requests. The most efficient phosphate solubilizing Gram-positive bacteria (PSB) belong to the genera <italic>Bacillus</italic>
. Besides, it has been reported that <italic>B. amyloliquefasciens, B. megaterium</italic>
, and <italic>Bacillus</italic>
sp., exhibit phosphorus, potassium, and zinc solubilization (<xref ref-type="fig" rid="F2">Figure 2</xref>
; <xref rid="B117" ref-type="bibr">Verma et al., 2015</xref>
).</p>
</sec>
<sec><title>Anticancer Activity of Gram-Positive Endophytic Bacteria</title>
<p>Cancer prevails as one of the leading causes of death worldwide, in spite of therapy advances (<xref rid="B48" ref-type="bibr">Global Cancer Observatory [GLOBOCAN], 2008</xref>
; <xref rid="B24" ref-type="bibr">Chen et al., 2013</xref>
). Conventional chemotherapy and radiotherapy have important disadvantages including drug resistance and serious side effects, which has prompted the search for new antitumor agents with high therapeutic efficacy and marginal or null detrimental effects.</p>
<p>Many endophytic actinomycete compounds were isolated and have found application not only as antimicrobial agents but also as cytotoxic agents against tumor cells (<xref ref-type="fig" rid="F1">Figure 1</xref>
, <xref ref-type="fig" rid="F3">3</xref>
). Some members of the Gram-positive bacteria group have been recently found as endophytes in different plant species (<xref rid="B37" ref-type="bibr">Eljounaidi et al., 2016</xref>
). Endophyte extracts have demonstrated to be a better choice versus chemotherapy agents due to their antitumor activity efficacy and lower side-effects, since they are less toxic to normal cells and more effective against several drug resistant microorganisms. As a consequence, the natural endophyte-derived metabolites have attracted peculiar attention with the purpose of being human cancer-chemopreventive compounds and anticancer chemotherapeutic drugs (<xref rid="B14" ref-type="bibr">Cardoso-Filho, 2018</xref>
; <xref ref-type="fig" rid="F3">Figure 3B,C</xref>
). Endophytic Gram-positive bacterial natural products have emerged as one of the most reliable alternative treatment sources (<xref rid="B53" ref-type="bibr">Gutierrez et al., 2012</xref>
; <xref rid="B24" ref-type="bibr">Chen et al., 2013</xref>
), including antitumor agents such as anthracyclines, anthraquinones, aureolic acids, β-glucans, carzinophilin, coumarins, enediynes, flavonoids, glycopeptides, macrotetrolides, mitomycins, naphthoquinones, polysaccharides, and quinoxalines (<xref rid="B121" ref-type="bibr">Waring and Wakelin, 1974</xref>
; <xref rid="B58" ref-type="bibr">Igarashi et al., 2007</xref>
; <xref rid="B112" ref-type="bibr">Taechowisan et al., 2007</xref>
; <xref rid="B24" ref-type="bibr">Chen et al., 2013</xref>
; <xref rid="B14" ref-type="bibr">Cardoso-Filho, 2018</xref>
; <xref ref-type="fig" rid="F3">Figure 3B,C</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
).</p>
<p>Actinomycetes, including the genera <italic>Actinomyces, Actinoplanes, Amycolatopsis, Micromonospora, Saccharopo-lyspora</italic>
, and <italic>Streptomyces</italic>
are recognized as producers of bioactive metabolites with not only antimicrobial, but also antitumor potential (<xref rid="B96" ref-type="bibr">Renu et al., 2008</xref>
; <xref rid="B67" ref-type="bibr">Kekuda et al., 2010</xref>
; <xref ref-type="fig" rid="F3">Figure 3C</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
). In this concern, <italic>Ophiopogon japonicus</italic>
-endophytic <italic>B. amyloliquefaciens</italic>
sp. exopolysaccharides were reported to possess antitumor activity against the human gastric carcinoma cell lines MC-4 and SGC-7901 (<xref rid="B24" ref-type="bibr">Chen et al., 2013</xref>
; <xref ref-type="fig" rid="F2">Figure 2A</xref>
). Furthermore, <italic>Maytenus hookeri</italic>
-maytansine-producing endophytic <italic>Streptomyces</italic>
sp. strain Is9131 inhibited human SGC7901 gastric, HL60 leukemia, BEL7402 liver, and A-549 lung tumor cell lines growth (<xref rid="B76" ref-type="bibr">Lu and Shen, 2003</xref>
; <xref rid="B128" ref-type="bibr">Zhao et al., 2005</xref>
; <xref ref-type="fig" rid="F3">Figure 3B</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
). <italic>Alnus glutinosa</italic>
-endophytic <italic>Streptomyces</italic>
alnumycin was reported to inhibit the growth of K562 human leukemia cells (<xref rid="B10" ref-type="bibr">Bieber et al., 1998</xref>
; <xref ref-type="fig" rid="F3">Figure 3C</xref>
), whereas <italic>Ricinus communis</italic>
-endophytic salaceyins-producing <italic>Streptomyces laceyi</italic>
strain MS53 was observed to be cytotoxic against the human breast cancer cell line SKBR3 (<xref rid="B69" ref-type="bibr">Kim et al., 2006</xref>
; <xref ref-type="fig" rid="F3">Figure 3B</xref>
). In addition, herbaceous and arbor plants-pterocidin-producing endophytic <italic>Streptomyces hygroscopicus</italic>
strain TP-A0451 was reported to inhibit human cancer cell lines NCI-H522, OVCAR-3, SF539, and LOX-IMVI growth (<xref rid="B57" ref-type="bibr">Igarashi et al., 2006</xref>
; <xref rid="B91" ref-type="bibr">Qin et al., 2011</xref>
), and <italic>Z. officinale</italic>
4-arylcoumarins-producing-endophytic <italic>Streptomyces aureofaciens</italic>
strain CMUAc130 was shown to be cytotoxic against murine Lewis lung carcinoma (<xref rid="B112" ref-type="bibr">Taechowisan et al., 2007</xref>
; <xref rid="B91" ref-type="bibr">Qin et al., 2011</xref>
; <xref ref-type="fig" rid="F3">Figure 3C</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
).</p>
<p>Many plant growth promoter compounds have shown cytotoxicity against tumor cells. Nodules of <italic>Lupinus angustifolius</italic>
-endophytic anthraquinones-producing <italic>Micromo-nospora</italic>
sp. actinomycete significantly inhibited invasion of murine colon 26-L5 carcinoma cells (<xref rid="B58" ref-type="bibr">Igarashi et al., 2007</xref>
; <xref rid="B91" ref-type="bibr">Qin et al., 2011</xref>
). Recently, <xref rid="B110" ref-type="bibr">Taechowisan et al. (2017)</xref>
reported anticancer activity of <italic>Boesenbergia rotunda</italic>
-endophytic biphenyls-producing <italic>Streptomyces</italic>
sp. strain BO-07 against human HepG2 and Huh7 liver, and HeLa cervical tumor cell lines (<xref ref-type="fig" rid="F3">Figure 3B</xref>
). Furthermore, <italic>Cinnamomum cassia</italic>
-endophytic <italic>Streptomyces cavourensis</italic>
strain YBQ59 was shown to inhibit human lung adenocarcinoma EGFR-TKI-resistant cells A549 and H1299 growth (<xref rid="B120" ref-type="bibr">Vu et al., 2018</xref>
; <xref ref-type="fig" rid="F3">Figure 3C</xref>
and <xref ref-type="supplementary-material" rid="SM1">Supplementary Table S4</xref>
).</p>
</sec>
<sec><title>Conclusion and Perspectives</title>
<p>Since the first reports of the industrial potential use of secondary metabolites produced by endophytes, there is more evidence that endophytic Gram-positive bacteria are one of the most important sources of novel compounds that have proven potential for either agriculture, medical and/or pharmaceutical application, thanks to their PGP, antimicrobial and anticancer activities. Indeed, endophytic Gram-positive bacteria help plants to better survive under biotic and abiotic stress conditions. It is not random that many endophytic Gram-positive have been isolated from medicinal plants from all over the world. In fact, many reports of endophytic Gram-positive bacteria showing such activities have been isolated from mangrove and under extreme environment conditions growing plants, like crops from salty soils and crops and trees from cold areas, where phylogenic analysis of native strains demonstrate they contain genes to produce different metabolites that, all together, are helping the host plant, not just to survive, but also to improve the plant adaptation to these extreme environmental conditions. In general, <italic>Bacillus</italic>
class endophytes have been reported to produce aromatic compounds, lipopeptides, plant hormones, polysaccharides, and several enzymes, thus representing higher potential in agriculture for PGP and crop management strategies (<xref rid="B119" ref-type="bibr">Villarreal-Delgado et al., 2018</xref>
). Similarly, Actinobacteria class endophytes are being found to produce antimicrobial- and antitumor-like activity metabolites, thus representing high potential for agriculture, medical, and veterinary application. In this minireview, we presented sources and specific isolated strains information, with the aim to provide current research highlights and perspectives for their future applications. These fascinating microorganisms are diverse and greatly adaptable to extreme stress conditions, making them excellent novel metabolites sources, whose application would be important for environmentally friendly and sustainable food and drugs production.</p>
</sec>
<sec><title>Author Contributions</title>
<p>All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.</p>
</sec>
<sec><title>Conflict of Interest Statement</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
</body>
<back><fn-group><fn fn-type="financial-disclosure"><p><bold>Funding.</bold>
This work was supported by Consejo Nacional de Ciencia y Tecnología, Grant No. 5109 to PTG and by Laboratorio de Inmunología y Virología del Departamento de Microbiología e Inmunologia (LIV-DEMI) de la FCB-UANL.</p>
</fn>
</fn-group>
<sec sec-type="supplementary material"><title>Supplementary Material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fmicb.2019.00463/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fmicb.2019.00463/full#supplementary-material</ext-link>
</p>
<supplementary-material content-type="local-data" id="SM1"><media xlink:href="Data_Sheet_1.pdf"><caption><p>Click here for additional data file.</p>
</caption>
</media>
</supplementary-material>
</sec>
<ref-list><title>References</title>
<ref id="B1"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Aitken</surname>
<given-names>G.</given-names>
</name>
</person-group>
(<year>2004</year>
). <source><italic>A New Approach to Conservation: The Importance of the Individual through Wildlife Rehabilitation.</italic>
</source>
<publisher-loc>London</publisher-loc>
: <publisher-name>Routledge</publisher-name>
.</mixed-citation>
</ref>
<ref id="B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Akinsanya</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Goh</surname>
<given-names>J. K.</given-names>
</name>
<name><surname>Lim</surname>
<given-names>S. P.</given-names>
</name>
<name><surname>Ting</surname>
<given-names>A. S. Y.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera.</article-title>
<source><italic>FEMS Microbiol. Lett.</italic>
</source>
<volume>362</volume>
:<issue>fnv184</issue>
. <pub-id pub-id-type="doi">10.1093/femsle/fnv184</pub-id>
<pub-id pub-id-type="pmid">26454221</pub-id>
</mixed-citation>
</ref>
<ref id="B3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alaimo</surname>
<given-names>S.</given-names>
</name>
<name><surname>Marceca</surname>
<given-names>G. P.</given-names>
</name>
<name><surname>Giugno</surname>
<given-names>R.</given-names>
</name>
<name><surname>Ferro</surname>
<given-names>A.</given-names>
</name>
<name><surname>Pulvirenti</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Current knowledge and computational techniques for grapevine meta-omics analysis.</article-title>
<source><italic>Front. Plant Sci.</italic>
</source>
<volume>8</volume>
:<issue>2241</issue>
. <pub-id pub-id-type="doi">10.3389/fpls.2017.02241</pub-id>
<pub-id pub-id-type="pmid">29375610</pub-id>
</mixed-citation>
</ref>
<ref id="B4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aloo</surname>
<given-names>B. N.</given-names>
</name>
<name><surname>Makumba</surname>
<given-names>B. A.</given-names>
</name>
<name><surname>Mbega</surname>
<given-names>E. R.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>The potential of bacilli rhizobacteria for sustainable crop production and environmental sustainability.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>219</volume>
<fpage>26</fpage>
–<lpage>39</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2018.10.011</pub-id>
<pub-id pub-id-type="pmid">30642464</pub-id>
</mixed-citation>
</ref>
<ref id="B5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Armada</surname>
<given-names>E.</given-names>
</name>
<name><surname>Probanza</surname>
<given-names>A.</given-names>
</name>
<name><surname>Roldán</surname>
<given-names>A.</given-names>
</name>
<name><surname>Azcón</surname>
<given-names>R.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Native plant growth promoting bacteria <italic>Bacillus thuringiensis</italic>
and mixed or individual mycorrhizal species improved drought tolerance and oxidative metabolism in <italic>Lavandula dentata</italic>
plants.</article-title>
<source><italic>J. Plant Physiol.</italic>
</source>
<volume>192</volume>
<fpage>1</fpage>
–<lpage>12</lpage>
. <pub-id pub-id-type="doi">10.1016/j.jplph.2015.11.007</pub-id>
<pub-id pub-id-type="pmid">26796423</pub-id>
</mixed-citation>
</ref>
<ref id="B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baldan</surname>
<given-names>E.</given-names>
</name>
<name><surname>Nigris</surname>
<given-names>S.</given-names>
</name>
<name><surname>Populin</surname>
<given-names>F.</given-names>
</name>
<name><surname>Zottini</surname>
<given-names>M.</given-names>
</name>
<name><surname>Squartini</surname>
<given-names>A.</given-names>
</name>
<name><surname>Baldan</surname>
<given-names>B.</given-names>
</name>
</person-group>
(<year>2014</year>
). <article-title>Identification of culturable bacterial endophyte community isolated from tissues of Vitis vinifera “Glera”.</article-title>
<source><italic>Plant Biosys.</italic>
</source>
<volume>148</volume>
<fpage>508</fpage>
–<lpage>516</lpage>
. <pub-id pub-id-type="doi">10.1080/11263504.2014.916364</pub-id>
</mixed-citation>
</ref>
<ref id="B7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beck</surname>
<given-names>H. C.</given-names>
</name>
<name><surname>Hansen</surname>
<given-names>A. M.</given-names>
</name>
<name><surname>Lauritsen</surname>
<given-names>F. R.</given-names>
</name>
</person-group>
(<year>2003</year>
). <article-title>Novel pyrazine metabolites found in polymyxin biosynthesis by <italic>Paenibacillus polymyxa</italic>
.</article-title>
<source><italic>FEMS Microbiol. Lett.</italic>
</source>
<volume>220</volume>
<fpage>67</fpage>
–<lpage>73</lpage>
. <pub-id pub-id-type="doi">10.1016/S0378-1097(03)00054-5</pub-id>
<pub-id pub-id-type="pmid">12644229</pub-id>
</mixed-citation>
</ref>
<ref id="B8"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beiranvand</surname>
<given-names>M.</given-names>
</name>
<name><surname>Amin</surname>
<given-names>M.</given-names>
</name>
<name><surname>Hashemi-Shahraki</surname>
<given-names>A.</given-names>
</name>
<name><surname>Romani</surname>
<given-names>B.</given-names>
</name>
<name><surname>Yaghoubi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Sadeghi</surname>
<given-names>P.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Antimicrobial activity of endophytic bacterial populations isolated from medical plants of Iran.</article-title>
<source><italic>Iran. J. Microbiol.</italic>
</source>
<volume>9</volume>
<fpage>11</fpage>
–<lpage>18</lpage>
. <pub-id pub-id-type="pmid">28775818</pub-id>
</mixed-citation>
</ref>
<ref id="B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Berg</surname>
<given-names>G.</given-names>
</name>
<name><surname>Krechel</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ditz</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sikora</surname>
<given-names>R. A.</given-names>
</name>
<name><surname>Ulrich</surname>
<given-names>A.</given-names>
</name>
<name><surname>Hallmann</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Endophytic and ectophytic potato-associated bacterial communities differ in structure and antagonistic function against plant pathogenic fungi.</article-title>
<source><italic>FEMS Microbiol. Ecol.</italic>
</source>
<volume>51</volume>
<fpage>215</fpage>
–<lpage>229</lpage>
. <pub-id pub-id-type="doi">10.1016/j.femsec.2004.08.006</pub-id>
<pub-id pub-id-type="pmid">16329870</pub-id>
</mixed-citation>
</ref>
<ref id="B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bieber</surname>
<given-names>B.</given-names>
</name>
<name><surname>Nüske</surname>
<given-names>J.</given-names>
</name>
<name><surname>Ritzau</surname>
<given-names>M.</given-names>
</name>
<name><surname>Gräfe</surname>
<given-names>U.</given-names>
</name>
</person-group>
(<year>1998</year>
). <article-title>Alnumycin a new naphthoquinone antibiotic produced by an endophytic <italic>Streptomyces</italic>
sp.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>51</volume>
<fpage>381</fpage>
–<lpage>382</lpage>
. <pub-id pub-id-type="doi">10.7164/antibiotics.51.381</pub-id>
<pub-id pub-id-type="pmid">9589078</pub-id>
</mixed-citation>
</ref>
<ref id="B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brader</surname>
<given-names>G.</given-names>
</name>
<name><surname>Compant</surname>
<given-names>S.</given-names>
</name>
<name><surname>Mitter</surname>
<given-names>B.</given-names>
</name>
<name><surname>Trognitz</surname>
<given-names>F.</given-names>
</name>
<name><surname>Sessitsch</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2014</year>
). <article-title>Metabolic potential of endophytic bacteria.</article-title>
<source><italic>Curr. Opin. Biotechnol.</italic>
</source>
<volume>27</volume>
<fpage>30</fpage>
–<lpage>37</lpage>
. <pub-id pub-id-type="doi">10.1016/j.copbio.2013.09.012</pub-id>
<pub-id pub-id-type="pmid">24863894</pub-id>
</mixed-citation>
</ref>
<ref id="B12"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cai</surname>
<given-names>X. C.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>C. H.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>B. T.</given-names>
</name>
<name><surname>Xue</surname>
<given-names>Y. R.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Genomic and metabolic traits endow bacillus velezensis CC09 with a potential biocontrol agent in control of wheat powdery mildew disease.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>196</volume>
<fpage>89</fpage>
–<lpage>94</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2016.12.007</pub-id>
<pub-id pub-id-type="pmid">28164794</pub-id>
</mixed-citation>
</ref>
<ref id="B13"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cankar</surname>
<given-names>K.</given-names>
</name>
<name><surname>Kraigher</surname>
<given-names>H.</given-names>
</name>
<name><surname>Ravnikar</surname>
<given-names>M.</given-names>
</name>
<name><surname>Rupnik</surname>
<given-names>M.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Bacterial endophytes from seeds of Norway spruce (<italic>Picea abies</italic>
L. Karst).</article-title>
<source><italic>FEMS Microbiol. Lett.</italic>
</source>
<volume>244</volume>
<fpage>341</fpage>
–<lpage>345</lpage>
. <pub-id pub-id-type="doi">10.1016/j.femsle.2005.02.008</pub-id>
<pub-id pub-id-type="pmid">15766788</pub-id>
</mixed-citation>
</ref>
<ref id="B14"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Cardoso-Filho</surname>
<given-names>J. A.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>“Endophytic microbes as a novel source for producing anticancer compounds as multidrug resistance modulators,” in</article-title>
<source><italic>Anticancer Plants: Natural Products and Biotechnological Implements</italic>
</source>
, <role>eds</role>
<person-group person-group-type="editor"><name><surname>Akhtar</surname>
<given-names>M.</given-names>
</name>
<name><surname>Swamy</surname>
<given-names>M.</given-names>
</name>
</person-group>
(<publisher-loc>Singapore</publisher-loc>
: <publisher-name>Springer</publisher-name>
), <fpage>343</fpage>
–<lpage>381</lpage>
.</mixed-citation>
</ref>
<ref id="B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Castillo</surname>
<given-names>U.</given-names>
</name>
<name><surname>Harper</surname>
<given-names>J. K.</given-names>
</name>
<name><surname>Strobel</surname>
<given-names>G. A.</given-names>
</name>
<name><surname>Sears</surname>
<given-names>J.</given-names>
</name>
<name><surname>Alesi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Ford</surname>
<given-names>E.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2003</year>
). <article-title>Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte of <italic>Grevillea pteridifolia</italic>
.</article-title>
<source><italic>FEMS Microbiol. Lett.</italic>
</source>
<volume>224</volume>
<fpage>183</fpage>
–<lpage>190</lpage>
. <pub-id pub-id-type="doi">10.1016/S0378-1097(03)00426-9</pub-id>
<pub-id pub-id-type="pmid">12892881</pub-id>
</mixed-citation>
</ref>
<ref id="B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Castillo</surname>
<given-names>U. F.</given-names>
</name>
<name><surname>Browne</surname>
<given-names>L.</given-names>
</name>
<name><surname>Strobel</surname>
<given-names>G. A.</given-names>
</name>
<name><surname>Hess</surname>
<given-names>W. M.</given-names>
</name>
<name><surname>Ezra</surname>
<given-names>S.</given-names>
</name>
<name><surname>Pacheco</surname>
<given-names>G.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2007</year>
). <article-title>Biologically active endophytic streptomycetes from <italic>Nothofagus</italic>
spp. and other plants in Patagonia.</article-title>
<source><italic>Microb. Ecol.</italic>
</source>
<volume>53</volume>
<fpage>12</fpage>
–<lpage>19</lpage>
. <pub-id pub-id-type="doi">10.1007/s00248-006-9129-6</pub-id>
<pub-id pub-id-type="pmid">16944339</pub-id>
</mixed-citation>
</ref>
<ref id="B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Castillo</surname>
<given-names>U. F.</given-names>
</name>
<name><surname>Strobel</surname>
<given-names>G. A.</given-names>
</name>
<name><surname>Ford</surname>
<given-names>E. J.</given-names>
</name>
<name><surname>Hess</surname>
<given-names>W. M.</given-names>
</name>
<name><surname>Porter</surname>
<given-names>H.</given-names>
</name>
<name><surname>Jensen</surname>
<given-names>J. B.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2002</year>
). <article-title>Munumbicins, wide-spectrum antibiotics produced by <italic>Streptomyces</italic>
NRRL30562, endophytic on <italic>Kennedia nigriscans</italic>
.</article-title>
<source><italic>Microbiology</italic>
</source>
<volume>148</volume>
<fpage>2675</fpage>
–<lpage>2685</lpage>
. <pub-id pub-id-type="doi">10.1099/00221287-148-9-2675</pub-id>
<pub-id pub-id-type="pmid">12213914</pub-id>
</mixed-citation>
</ref>
<ref id="B18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Castillo</surname>
<given-names>U. F.</given-names>
</name>
<name><surname>Strobel</surname>
<given-names>G. A.</given-names>
</name>
<name><surname>Mullenberg</surname>
<given-names>K.</given-names>
</name>
<name><surname>Condron</surname>
<given-names>M. M.</given-names>
</name>
<name><surname>Teplow</surname>
<given-names>D. B.</given-names>
</name>
<name><surname>Folgiano</surname>
<given-names>V.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2006</year>
). <article-title>Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from <italic>Streptomyces</italic>
NRRL 3052.</article-title>
<source><italic>FEMS Microbiol. Lett.</italic>
</source>
<volume>255</volume>
<fpage>296</fpage>
–<lpage>300</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1574-6968.2005.00080.x</pub-id>
<pub-id pub-id-type="pmid">16448509</pub-id>
</mixed-citation>
</ref>
<ref id="B19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Castro</surname>
<given-names>R. A.</given-names>
</name>
<name><surname>Quecine</surname>
<given-names>M. C.</given-names>
</name>
<name><surname>Lacava</surname>
<given-names>P. T.</given-names>
</name>
<name><surname>Batista</surname>
<given-names>B. D.</given-names>
</name>
<name><surname>Luvizotto</surname>
<given-names>D. M.</given-names>
</name>
<name><surname>Marcon</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Isolation and enzyme bioprospection of endophytic bacteria associated with plants of Brazilian mangrove ecosystem.</article-title>
<source><italic>SpringerPlus</italic>
</source>
<volume>3</volume>
:<issue>382</issue>
. <pub-id pub-id-type="doi">10.1186/2193-1801-3-382</pub-id>
<pub-id pub-id-type="pmid">25110630</pub-id>
</mixed-citation>
</ref>
<ref id="B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cazorla</surname>
<given-names>F. M.</given-names>
</name>
<name><surname>Romero</surname>
<given-names>D.</given-names>
</name>
<name><surname>Pérez-García</surname>
<given-names>A.</given-names>
</name>
<name><surname>Lugtenberg</surname>
<given-names>B. J. J.</given-names>
</name>
<name><surname>Vicente</surname>
<given-names>A. D.</given-names>
</name>
<name><surname>Bloemberg</surname>
<given-names>G.</given-names>
</name>
</person-group>
(<year>2007</year>
). <article-title>Isolation and characterization of antagonistic Bacillus subtilis strains from the avocado rhizoplane displaying biocontrol activity.</article-title>
<source><italic>J. Appl. Microbiol.</italic>
</source>
<volume>103</volume>
<fpage>1950</fpage>
–<lpage>1959</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1365-2672.2007.03433.x</pub-id>
<pub-id pub-id-type="pmid">17953605</pub-id>
</mixed-citation>
</ref>
<ref id="B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chandrakar</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>A. K.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Antibiotic potential of endophytic actinomycetes of medicinal herbs against human pathogenic bacteria.</article-title>
<source><italic>Proc. Natl. Acad. Sci. India Biol. Sci.</italic>
</source>
<volume>87</volume>
<fpage>905</fpage>
–<lpage>915</lpage>
. <pub-id pub-id-type="pmid">18062256</pub-id>
</mixed-citation>
</ref>
<ref id="B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chandrakar</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>A. K.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Actinomycin-producing endophytic <italic>Streptomyces parvulus</italic>
associated with root of aloe vera and optimization of conditions for antibiotic production.</article-title>
<source><italic>Probiotics Antimicrob. Prot.</italic>
</source>
<pub-id pub-id-type="doi">10.1007/s12602-018-9451-6</pub-id>
[Epub ahead of print]. <pub-id pub-id-type="pmid">30058033</pub-id>
</mixed-citation>
</ref>
<ref id="B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chatterjee</surname>
<given-names>P.</given-names>
</name>
<name><surname>Samaddar</surname>
<given-names>S.</given-names>
</name>
<name><surname>Niinemets</surname>
<given-names>Ü.</given-names>
</name>
<name><surname>Sa</surname>
<given-names>T. M.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Brevibacterium linens RS16 confers salt tolerance to Oryza sativa genotypes by regulating antioxidant defense and H+ ATPase activity.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>215</volume>
<fpage>89</fpage>
–<lpage>101</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2018.06.007</pub-id>
<pub-id pub-id-type="pmid">30172313</pub-id>
</mixed-citation>
</ref>
<ref id="B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname>
<given-names>Y. T.</given-names>
</name>
<name><surname>Yuan</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Shan</surname>
<given-names>L. T.</given-names>
</name>
<name><surname>Lin</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Cheng</surname>
<given-names>D. Q.</given-names>
</name>
<name><surname>Li</surname>
<given-names>C. Y.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Antitumor activity of bacterial exopolysaccharides from the endophyte Bacillus amyloliquefaciens sp. Isolated from <italic>Ophiopogon japonicus</italic>
.</article-title>
<source><italic>Oncol. Lett.</italic>
</source>
<volume>5</volume>
<fpage>1787</fpage>
–<lpage>1792</lpage>
. <pub-id pub-id-type="doi">10.3892/ol.2013.1284</pub-id>
<pub-id pub-id-type="pmid">23833642</pub-id>
</mixed-citation>
</ref>
<ref id="B25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chinedum</surname>
<given-names>I. E.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Microbial resistance to antibiotics.</article-title>
<source><italic>Afr. J. Biotechnol.</italic>
</source>
<volume>10</volume>
<fpage>1606</fpage>
–<lpage>1611</lpage>
.</mixed-citation>
</ref>
<ref id="B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Christina</surname>
<given-names>A.</given-names>
</name>
<name><surname>Christapher</surname>
<given-names>V.</given-names>
</name>
<name><surname>Bhore</surname>
<given-names>S. J.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Endophytic bacteria as a source of novel antibiotics: an overview.</article-title>
<source><italic>Pharmacog. Rev.</italic>
</source>
<volume>7</volume>
<fpage>11</fpage>
–<lpage>16</lpage>
. <pub-id pub-id-type="doi">10.4103/0973-7847.112833</pub-id>
<pub-id pub-id-type="pmid">23922451</pub-id>
</mixed-citation>
</ref>
<ref id="B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Compant</surname>
<given-names>S.</given-names>
</name>
<name><surname>Mitter</surname>
<given-names>B.</given-names>
</name>
<name><surname>Colli-Mull</surname>
<given-names>J. G.</given-names>
</name>
<name><surname>Gangl</surname>
<given-names>H.</given-names>
</name>
<name><surname>Sessitsch</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Endophytes of grapevine flowers, berries, and seeds: identification of cultivable bacteria, comparison with other plant parts, and visualization of niches of colonization.</article-title>
<source><italic>Microb. Ecol.</italic>
</source>
<volume>62</volume>
<fpage>188</fpage>
–<lpage>197</lpage>
. <pub-id pub-id-type="doi">10.1007/s00248-011-9883-y</pub-id>
<pub-id pub-id-type="pmid">21625971</pub-id>
</mixed-citation>
</ref>
<ref id="B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Damodaran</surname>
<given-names>T.</given-names>
</name>
<name><surname>Rai</surname>
<given-names>R. B.</given-names>
</name>
<name><surname>Jha</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Kannan</surname>
<given-names>R.</given-names>
</name>
<name><surname>Pandey</surname>
<given-names>B. K.</given-names>
</name>
<name><surname>Sah</surname>
<given-names>V.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Rhizosphere and endophytic bacteria for induction of salt tolerance in gladiolus grown in sodic soils.</article-title>
<source><italic>J. Plant Interact.</italic>
</source>
<volume>9</volume>
<fpage>577</fpage>
–<lpage>584</lpage>
. <pub-id pub-id-type="doi">10.1080/17429145.2013.873958</pub-id>
</mixed-citation>
</ref>
<ref id="B29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Lima Procópio</surname>
<given-names>R. E.</given-names>
</name>
<name><surname>da Silva</surname>
<given-names>I. R.</given-names>
</name>
<name><surname>Martins</surname>
<given-names>M. K.</given-names>
</name>
<name><surname>de Azevedo</surname>
<given-names>J. L.</given-names>
</name>
<name><surname>de Araújo</surname>
<given-names>J. M.</given-names>
</name>
</person-group>
(<year>2012</year>
). <article-title>Antibiotics produced by streptomyces.</article-title>
<source><italic>Braz. J. Infect. Dis.</italic>
</source>
<volume>16</volume>
<fpage>466</fpage>
–<lpage>471</lpage>
. <pub-id pub-id-type="doi">10.1016/j.bjid.2012.08.014</pub-id>
<pub-id pub-id-type="pmid">22975171</pub-id>
</mixed-citation>
</ref>
<ref id="B30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Melo-Pereira</surname>
<given-names>G. V.</given-names>
</name>
<name><surname>Magalhães</surname>
<given-names>K. T.</given-names>
</name>
<name><surname>Lorenzetii</surname>
<given-names>E. R.</given-names>
</name>
<name><surname>Souza</surname>
<given-names>T. P.</given-names>
</name>
<name><surname>Schwan</surname>
<given-names>R. F.</given-names>
</name>
</person-group>
(<year>2012</year>
). <article-title>A multiphasic approach for the identification of endophytic bacterial in strawberry fruit and their potential for plant growth promotion.</article-title>
<source><italic>Microb. Ecol.</italic>
</source>
<volume>63</volume>
<fpage>405</fpage>
–<lpage>417</lpage>
. <pub-id pub-id-type="doi">10.1007/s00248-011-9919-3</pub-id>
<pub-id pub-id-type="pmid">21837472</pub-id>
</mixed-citation>
</ref>
<ref id="B31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Demain</surname>
<given-names>A. L.</given-names>
</name>
</person-group>
(<year>1981</year>
). <article-title>Industrial microbiology.</article-title>
<source><italic>Science</italic>
</source>
<volume>214</volume>
<fpage>987</fpage>
–<lpage>994</lpage>
. <pub-id pub-id-type="doi">10.1126/science.6946560</pub-id>
<pub-id pub-id-type="pmid">6946560</pub-id>
</mixed-citation>
</ref>
<ref id="B32"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Deng</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>P.</given-names>
</name>
<name><surname>Zhu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Zheng</surname>
<given-names>J.</given-names>
</name>
<name><surname>Li</surname>
<given-names>R.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2011</year>
). <article-title>Complete genome sequence of Bacillus subtilis BSn5, an endophytic bacterium of <italic>Amorphophallus konjac</italic>
with antimicrobial activity for the plant pathogen <italic>Erwinia carotovora</italic>
subsp. Carotovora.</article-title>
<source><italic>J. Bacteriol.</italic>
</source>
<volume>193</volume>
<fpage>2070</fpage>
–<lpage>2071</lpage>
. <pub-id pub-id-type="doi">10.1128/JB.00129-11</pub-id>
<pub-id pub-id-type="pmid">21317323</pub-id>
</mixed-citation>
</ref>
<ref id="B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Diale</surname>
<given-names>M. O.</given-names>
</name>
<name><surname>Ubomba-Jaswa</surname>
<given-names>E.</given-names>
</name>
<name><surname>Serepa-Dlamini</surname>
<given-names>M. H.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>The antibacterial activity of bacterial endophytes isolated from Combretum molle.</article-title>
<source><italic>Afr. J. Biotechnol.</italic>
</source>
<volume>17</volume>
<fpage>255</fpage>
–<lpage>262</lpage>
. <pub-id pub-id-type="doi">10.5897/AJB2017.16349</pub-id>
</mixed-citation>
</ref>
<ref id="B34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ding</surname>
<given-names>L.</given-names>
</name>
<name><surname>Maier</surname>
<given-names>A.</given-names>
</name>
<name><surname>Fiebig</surname>
<given-names>H. H.</given-names>
</name>
<name><surname>Lin</surname>
<given-names>W. H.</given-names>
</name>
<name><surname>Hertweck</surname>
<given-names>C.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>A family of multicyclic indolosesquiterpenes from a bacterial endophyte.</article-title>
<source><italic>Organ. Biomol. Chem.</italic>
</source>
<volume>9</volume>
<fpage>4029</fpage>
–<lpage>4031</lpage>
. <pub-id pub-id-type="doi">10.1039/c1ob05283g</pub-id>
<pub-id pub-id-type="pmid">21528153</pub-id>
</mixed-citation>
</ref>
<ref id="B35"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ding</surname>
<given-names>L.</given-names>
</name>
<name><surname>Münch</surname>
<given-names>J.</given-names>
</name>
<name><surname>Goerls</surname>
<given-names>H.</given-names>
</name>
<name><surname>Maier</surname>
<given-names>A.</given-names>
</name>
<name><surname>Fiebig</surname>
<given-names>H. H.</given-names>
</name>
<name><surname>Lin</surname>
<given-names>W. H.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2010</year>
). <article-title>Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte.</article-title>
<source><italic>Bioorg. Med. Chem. Lett.</italic>
</source>
<volume>20</volume>
<fpage>6685</fpage>
–<lpage>6687</lpage>
. <pub-id pub-id-type="doi">10.1016/j.bmcl.2010.09.010</pub-id>
<pub-id pub-id-type="pmid">20880706</pub-id>
</mixed-citation>
</ref>
<ref id="B36"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>El-Deeb</surname>
<given-names>B.</given-names>
</name>
<name><surname>Fayez</surname>
<given-names>K.</given-names>
</name>
<name><surname>Gherbawy</surname>
<given-names>Y.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Isolation and characterization of endophytic bacteria from Plectranthus tenuiflorus medicinal plant in Saudi Arabia desert and their antimicrobial activities.</article-title>
<source><italic>J. Plant Interact.</italic>
</source>
<volume>8</volume>
<fpage>56</fpage>
–<lpage>64</lpage>
. <pub-id pub-id-type="doi">10.1080/17429145.2012.680077</pub-id>
</mixed-citation>
</ref>
<ref id="B37"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eljounaidi</surname>
<given-names>K.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Bae</surname>
<given-names>H.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Bacterial endophytes as potential biocontrol agents of vascular wilt diseases – Review and future prospects.</article-title>
<source><italic>Biol. Control</italic>
</source>
<volume>103</volume>
<fpage>62</fpage>
–<lpage>68</lpage>
. <pub-id pub-id-type="doi">10.1016/j.biocontrol.2016.07.013</pub-id>
</mixed-citation>
</ref>
<ref id="B38"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Etesami</surname>
<given-names>H.</given-names>
</name>
<name><surname>Alikhani</surname>
<given-names>H. A.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Evaluation of gram-positive rhizosphere and endophytic bacteria for biological control of fungal rice (<italic>Oryzia sativa</italic>
L.) pathogens.</article-title>
<source><italic>Eur. J. Plant Pathol.</italic>
</source>
<volume>147</volume>
<fpage>7</fpage>
–<lpage>14</lpage>
. <pub-id pub-id-type="doi">10.1007/s10658-016-0981-z</pub-id>
</mixed-citation>
</ref>
<ref id="B39"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ezra</surname>
<given-names>D.</given-names>
</name>
<name><surname>Castillo</surname>
<given-names>U. F.</given-names>
</name>
<name><surname>Strobel</surname>
<given-names>G. A.</given-names>
</name>
<name><surname>Hess</surname>
<given-names>W. M.</given-names>
</name>
<name><surname>Porter</surname>
<given-names>H.</given-names>
</name>
<name><surname>Jensen</surname>
<given-names>J. B.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2004</year>
). <article-title>Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. <italic>(MSU</italic>
-2110) endophytic on Monstera sp.</article-title>
<source><italic>Microbiology</italic>
</source>
<volume>150</volume>
<fpage>785</fpage>
–<lpage>793</lpage>
. <pub-id pub-id-type="doi">10.1099/mic.0.26645-0</pub-id>
<pub-id pub-id-type="pmid">15073289</pub-id>
</mixed-citation>
</ref>
<ref id="B40"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferrigo</surname>
<given-names>D.</given-names>
</name>
<name><surname>Causin</surname>
<given-names>R.</given-names>
</name>
<name><surname>Raiola</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Effect of potential biocontrol agents selected among grapevine endophytes and commercial products on crown gall disease.</article-title>
<source><italic>BioControl</italic>
</source>
<volume>62</volume>
<fpage>821</fpage>
–<lpage>833</lpage>
. <pub-id pub-id-type="doi">10.1007/s10526-017-9847-3</pub-id>
</mixed-citation>
</ref>
<ref id="B41"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Fikri</surname>
<given-names>A. S. I.</given-names>
</name>
<name><surname>Rahman</surname>
<given-names>I. A.</given-names>
</name>
<name><surname>Nor</surname>
<given-names>N. S. M.</given-names>
</name>
<name><surname>Hamzah</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>“Isolation and identification of local bacteria endophyte and screening of its antimicrobial property against pathogenic bacteria and fungi,” in</article-title>
<source><italic>Proceedings of AIP Conference</italic>
</source>
<volume>Vol. 1940</volume>
(<publisher-loc>Melville, NY</publisher-loc>
: <publisher-name>AIP Publishing</publisher-name>
), 020072. <pub-id pub-id-type="doi">10.1063/1.5027987</pub-id>
</mixed-citation>
</ref>
<ref id="B42"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Frank</surname>
<given-names>A.</given-names>
</name>
<name><surname>Saldierna-Guzmán</surname>
<given-names>J.</given-names>
</name>
<name><surname>Shay</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Transmission of bacterial endophytes.</article-title>
<source><italic>Microorganisms</italic>
</source>
<volume>5</volume>
:<issue>E70</issue>
. <pub-id pub-id-type="doi">10.3390/microorganisms5040070</pub-id>
<pub-id pub-id-type="pmid">29125552</pub-id>
</mixed-citation>
</ref>
<ref id="B43"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gagné-Bourque</surname>
<given-names>F.</given-names>
</name>
<name><surname>Mayer</surname>
<given-names>B. B. F.</given-names>
</name>
<name><surname>Charron</surname>
<given-names>J.-B. B.</given-names>
</name>
<name><surname>Vali</surname>
<given-names>H.</given-names>
</name>
<name><surname>Bertrand</surname>
<given-names>A.</given-names>
</name>
<name><surname>Jabaji</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Accelerated growth rate and increased drought stress resilience of the model grass <italic>Brachypodium distachyon</italic>
colonized by Bacillus subtilis B26.</article-title>
<source><italic>PLoS One</italic>
</source>
<volume>10</volume>
:<issue>e130456</issue>
. <pub-id pub-id-type="doi">10.1371/journal.pone.0130456</pub-id>
<pub-id pub-id-type="pmid">26103151</pub-id>
</mixed-citation>
</ref>
<ref id="B44"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gamez</surname>
<given-names>R.</given-names>
</name>
<name><surname>Cardinale</surname>
<given-names>M.</given-names>
</name>
<name><surname>Montes</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ramirez</surname>
<given-names>S.</given-names>
</name>
<name><surname>Schnell</surname>
<given-names>S.</given-names>
</name>
<name><surname>Rodriguez</surname>
<given-names>F.</given-names>
</name>
</person-group>
(<year>2019</year>
). <article-title>Screening, plant growth promotion and root colonization pattern of two rhizobacteria (<italic>Pseudomonas</italic>
fluorescens Ps006 and <italic>Bacillus amyloliquefaciens</italic>
Bs006) on banana cv. Williams (<italic>Musa acuminata Colla</italic>
).</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>220</volume>
<fpage>12</fpage>
–<lpage>20</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2018.11.006</pub-id>
<pub-id pub-id-type="pmid">30744815</pub-id>
</mixed-citation>
</ref>
<ref id="B45"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gayathri</surname>
<given-names>P.</given-names>
</name>
<name><surname>Muralikrishnan</surname>
<given-names>V.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Isolation and characterization of endophytic actinomycetes from mangrove plant for antimicrobial activity.</article-title>
<source><italic>Int. J. Curr. Microbiol. Appl. Sci.</italic>
</source>
<volume>2</volume>
<fpage>78</fpage>
–<lpage>89</lpage>
.</mixed-citation>
</ref>
<ref id="B46"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ghadin</surname>
<given-names>N.</given-names>
</name>
<name><surname>Zin</surname>
<given-names>N. M.</given-names>
</name>
<name><surname>Sabaratnam</surname>
<given-names>V.</given-names>
</name>
<name><surname>Badya</surname>
<given-names>N.</given-names>
</name>
<name><surname>Basri</surname>
<given-names>D. F.</given-names>
</name>
<name><surname>Lian</surname>
<given-names>H. H.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2008</year>
). <article-title>Isolation and characterization of a novel endophytic Streptomyces SUK 06 with antimicrobial activity from Malaysian plant.</article-title>
<source><italic>Asian J. Plant Sci.</italic>
</source>
<volume>7</volume>
<fpage>189</fpage>
–<lpage>194</lpage>
. <pub-id pub-id-type="doi">10.3923/ajps.2008.189.194</pub-id>
</mixed-citation>
</ref>
<ref id="B47"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Giassi</surname>
<given-names>V.</given-names>
</name>
<name><surname>Kiritani</surname>
<given-names>C.</given-names>
</name>
<name><surname>Kupper</surname>
<given-names>K. C.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Bacteria as growth-promoting agents for citrus rootstocks.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>190</volume>
<fpage>46</fpage>
–<lpage>54</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2015.12.006</pub-id>
<pub-id pub-id-type="pmid">27393998</pub-id>
</mixed-citation>
</ref>
<ref id="B48"><mixed-citation publication-type="journal"><collab>Global Cancer Observatory [GLOBOCAN]</collab>
(<year>2008</year>
). <source><italic>Section of Cancer Information WHO.</italic>
</source>
Available at: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/mediacentre/factsheets/fs297/en/">http://www.who.int/mediacentre/factsheets/fs297/en/</ext-link>
[accessed August 05 2018].</mixed-citation>
</ref>
<ref id="B49"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gond</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Bergen</surname>
<given-names>M. S.</given-names>
</name>
<name><surname>Torres</surname>
<given-names>M. S.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Endophytic bacillus spp. Produce antifungal lipopeptides and induce host defence gene expression in maize.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>172</volume>
<fpage>79</fpage>
–<lpage>87</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2014.11.004</pub-id>
<pub-id pub-id-type="pmid">25497916</pub-id>
</mixed-citation>
</ref>
<ref id="B50"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gowtham</surname>
<given-names>H. G.</given-names>
</name>
<name><surname>Murali</surname>
<given-names>M.</given-names>
</name>
<name><surname>Singh</surname>
<given-names>S. B.</given-names>
</name>
<name><surname>Lakshmeesha</surname>
<given-names>T. R.</given-names>
</name>
<name><surname>Murthy</surname>
<given-names>K. N.</given-names>
</name>
<name><surname>Amruthesh</surname>
<given-names>K. N.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Plant growth promoting rhizobacteria <italic>Bacillus amyloliquefaciens</italic>
improves plant growth and induces resistance in chilli against anthracnose disease.</article-title>
<source><italic>Biol. Control</italic>
</source>
<volume>126</volume>
<fpage>209</fpage>
–<lpage>217</lpage>
. <pub-id pub-id-type="doi">10.1016/j.biocontrol.2018.05.022</pub-id>
</mixed-citation>
</ref>
<ref id="B51"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grady</surname>
<given-names>E. N.</given-names>
</name>
<name><surname>MacDonald</surname>
<given-names>J.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Richman</surname>
<given-names>A.</given-names>
</name>
<name><surname>Yuan</surname>
<given-names>Z. C.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Current knowledge and perspectives of paenibacillus: a review. .</article-title>
<source><italic>Microb. Cell Fact</italic>
</source>
<volume>15</volume>
:<issue>203</issue>
. <pub-id pub-id-type="doi">10.1186/s12934-016-0603-7</pub-id>
<pub-id pub-id-type="pmid">27905924</pub-id>
</mixed-citation>
</ref>
<ref id="B52"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guan</surname>
<given-names>S. H.</given-names>
</name>
<name><surname>Sattler</surname>
<given-names>I.</given-names>
</name>
<name><surname>Lin</surname>
<given-names>W. H.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>D. A.</given-names>
</name>
<name><surname>Grabley</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>p-Aminoacetophenonic acids produced by a mangrove endophyte: <italic>Streptomyces griseus</italic>
subspecies.</article-title>
<source><italic>J. Nat. Prod.</italic>
</source>
<volume>68</volume>
<fpage>1198</fpage>
–<lpage>1200</lpage>
. <pub-id pub-id-type="doi">10.1021/np0500777</pub-id>
<pub-id pub-id-type="pmid">16124760</pub-id>
</mixed-citation>
</ref>
<ref id="B53"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gutierrez</surname>
<given-names>R. M.</given-names>
</name>
<name><surname>Gonzalez</surname>
<given-names>A. M.</given-names>
</name>
<name><surname>Ramirez</surname>
<given-names>A. M.</given-names>
</name>
</person-group>
(<year>2012</year>
). <article-title>Compounds derived from endophytes: a review of phytochemistry and pharmacology.</article-title>
<source><italic>Curr. Med. Chem.</italic>
</source>
<volume>19</volume>
<fpage>2992</fpage>
–<lpage>3030</lpage>
. <pub-id pub-id-type="doi">10.2174/092986712800672111</pub-id>
<pub-id pub-id-type="pmid">22489725</pub-id>
</mixed-citation>
</ref>
<ref id="B54"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haidar</surname>
<given-names>R.</given-names>
</name>
<name><surname>Roudet</surname>
<given-names>J.</given-names>
</name>
<name><surname>Bonnard</surname>
<given-names>O.</given-names>
</name>
<name><surname>Dufour</surname>
<given-names>M. C.</given-names>
</name>
<name><surname>Corio-Costet</surname>
<given-names>M. F.</given-names>
</name>
<name><surname>Fert</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2016</year>
). <article-title>Screening and modes of action of antagonistic bacteria to control the fungal pathogen <italic>Phaeomoniella chlamydospora</italic>
involved in grapevine trunk diseases.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>192</volume>
<fpage>172</fpage>
–<lpage>184</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2016.07.003</pub-id>
<pub-id pub-id-type="pmid">27664735</pub-id>
</mixed-citation>
</ref>
<ref id="B55"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Housman</surname>
<given-names>G.</given-names>
</name>
<name><surname>Byler</surname>
<given-names>S.</given-names>
</name>
<name><surname>Heerboth</surname>
<given-names>S.</given-names>
</name>
<name><surname>Lapinska</surname>
<given-names>K.</given-names>
</name>
<name><surname>Longacre</surname>
<given-names>M.</given-names>
</name>
<name><surname>Snyder</surname>
<given-names>N.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2014</year>
). <article-title>Drug resistance in cancer: an overview.</article-title>
<source><italic>Cancers</italic>
</source>
<volume>6</volume>
<fpage>1769</fpage>
–<lpage>1792</lpage>
. <pub-id pub-id-type="doi">10.3390/cancers6031769</pub-id>
<pub-id pub-id-type="pmid">25198391</pub-id>
</mixed-citation>
</ref>
<ref id="B56"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hu</surname>
<given-names>H. Q.</given-names>
</name>
<name><surname>Li</surname>
<given-names>X. S.</given-names>
</name>
<name><surname>He</surname>
<given-names>H.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Characterization of an antimicrobial material from a newly isolated <italic>Bacillus amyloliquefaciens</italic>
from mangrove for biocontrol of Capsicum bacterial wilt.</article-title>
<source><italic>Biol. Control</italic>
</source>
<volume>54</volume>
<fpage>359</fpage>
–<lpage>365</lpage>
. <pub-id pub-id-type="doi">10.1016/j.biocontrol.2010.06.015</pub-id>
</mixed-citation>
</ref>
<ref id="B57"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Igarashi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Miura</surname>
<given-names>S. S.</given-names>
</name>
<name><surname>Fujita</surname>
<given-names>T.</given-names>
</name>
<name><surname>Furumai</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>2006</year>
). <article-title>Pterocidin, a cytotoxic compound from the endophytic <italic>Streptomyces hygroscopicus</italic>
.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>59</volume>
<fpage>193</fpage>
–<lpage>195</lpage>
. <pub-id pub-id-type="doi">10.1038/ja.2006.28</pub-id>
<pub-id pub-id-type="pmid">16724461</pub-id>
</mixed-citation>
</ref>
<ref id="B58"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Igarashi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Trujillo</surname>
<given-names>M. E.</given-names>
</name>
<name><surname>Martínez-Molina</surname>
<given-names>E.</given-names>
</name>
<name><surname>Yanase</surname>
<given-names>S.</given-names>
</name>
<name><surname>Miyanaga</surname>
<given-names>S.</given-names>
</name>
<name><surname>Obata</surname>
<given-names>T.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2007</year>
). <article-title>Antitumor anthraquinones from an endophytic actinomycete <italic>Micromonospora lupine</italic>
sp, nov.</article-title>
<source><italic>Bioorg. Med. Chem. Lett.</italic>
</source>
<volume>17</volume>
<fpage>3702</fpage>
–<lpage>3705</lpage>
. <pub-id pub-id-type="doi">10.1016/j.bmcl.2007.04.039</pub-id>
<pub-id pub-id-type="pmid">17475486</pub-id>
</mixed-citation>
</ref>
<ref id="B59"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Inahashi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Iwatsuki</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ishiyama</surname>
<given-names>A.</given-names>
</name>
<name><surname>Namatame</surname>
<given-names>M.</given-names>
</name>
<name><surname>Nishihara-Tsukashima</surname>
<given-names>A.</given-names>
</name>
<name><surname>Matsumoto</surname>
<given-names>A.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2011a</year>
). <article-title>Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete. Streptosporangium oxazolinicum K07-0460T.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>64</volume>
<fpage>303</fpage>
–<lpage>307</lpage>
. <pub-id pub-id-type="doi">10.1038/ja.2011.16</pub-id>
<pub-id pub-id-type="pmid">21386848</pub-id>
</mixed-citation>
</ref>
<ref id="B60"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Inahashi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Matsumoto</surname>
<given-names>A.</given-names>
</name>
<name><surname>Mura</surname>
<given-names>S.</given-names>
</name>
<name><surname>Takahashi</surname>
<given-names>Y.</given-names>
</name>
</person-group>
(<year>2011b</year>
). <article-title>Streptosporangium oxazolinicum sp. nov., a novel endophytic actinomycete producing new antitrypanosomal antibiotics, spoxazomicins.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>64</volume>
<fpage>297</fpage>
–<lpage>302</lpage>
. <pub-id pub-id-type="doi">10.1038/ja.2011.18</pub-id>
<pub-id pub-id-type="pmid">21386852</pub-id>
</mixed-citation>
</ref>
<ref id="B61"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Indrawati</surname>
<given-names>I.</given-names>
</name>
<name><surname>Rossiana</surname>
<given-names>N.</given-names>
</name>
<name><surname>Hidayat</surname>
<given-names>T. R.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>“Antibacterial activity of bacterial endophytes from Kupa plant (Syzygium polycephalum Miq. (Merr & Perry) against pathogenic bacteria,” in</article-title>
<source><italic>Proceedings of the IOP Conference Series: Earth and Environmental Science</italic>
</source>
<volume>Vol. 166</volume>
(<publisher-loc>Bristol</publisher-loc>
: <publisher-name>IOP Publishing</publisher-name>
), 012013. <pub-id pub-id-type="doi">10.1088/1755-1315/166/1/012013</pub-id>
</mixed-citation>
</ref>
<ref id="B62"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jakubiec-Krzesniak</surname>
<given-names>K.</given-names>
</name>
<name><surname>Rajnisz-Mateusiak</surname>
<given-names>A.</given-names>
</name>
<name><surname>Guspiel</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ziemska</surname>
<given-names>J.</given-names>
</name>
<name><surname>Solecka</surname>
<given-names>J.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Secondary metabolites of actinomycetes and their antibacterial, antifungal and antiviral properties.</article-title>
<source><italic>Pol. J. Microbiol.</italic>
</source>
<volume>67</volume>
<fpage>259</fpage>
–<lpage>272</lpage>
. <pub-id pub-id-type="doi">10.21307/pjm-2018-048</pub-id>
<pub-id pub-id-type="pmid">30451442</pub-id>
</mixed-citation>
</ref>
<ref id="B63"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jiang</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Tuo</surname>
<given-names>L.</given-names>
</name>
<name><surname>Huang</surname>
<given-names>D.</given-names>
</name>
<name><surname>Osterman</surname>
<given-names>I. A.</given-names>
</name>
<name><surname>Tyurin</surname>
<given-names>A.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>S.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Diversity, novelty and antimicrobial activity of endophytic actinobacteria from mangrove plants in Beilun estuary national nature reserve of Guangxi. China.</article-title>
<source><italic>Front. Microbiol.</italic>
</source>
<volume>9</volume>
:<issue>868</issue>
. <pub-id pub-id-type="doi">10.3389/fmicb.2018.00868</pub-id>
<pub-id pub-id-type="pmid">29780376</pub-id>
</mixed-citation>
</ref>
<ref id="B64"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Johnston-Monje</surname>
<given-names>D.</given-names>
</name>
<name><surname>Raizada</surname>
<given-names>M. N.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Conservation and diversity of seed associated endophytes in Zea across boundaries of evolution, ethnography and ecology.</article-title>
<source><italic>PLoS One</italic>
</source>
<volume>6</volume>
:<issue>e20396</issue>
. <pub-id pub-id-type="doi">10.1371/journal.pone.0020396</pub-id>
<pub-id pub-id-type="pmid">21673982</pub-id>
</mixed-citation>
</ref>
<ref id="B65"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Karlidag</surname>
<given-names>H.</given-names>
</name>
<name><surname>Esitken</surname>
<given-names>A.</given-names>
</name>
<name><surname>Yildirim</surname>
<given-names>E.</given-names>
</name>
<name><surname>Donmez</surname>
<given-names>M. F.</given-names>
</name>
<name><surname>Turan</surname>
<given-names>M.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Effects of plant growth promoting bacteria on yield, growth, leaf water content, membrane permeability, and ionic composition of strawberry under saline conditions.</article-title>
<source><italic>J. Plant Nutr.</italic>
</source>
<volume>34</volume>
<fpage>34</fpage>
–<lpage>45</lpage>
. <pub-id pub-id-type="doi">10.1080/01904167.2011.531357</pub-id>
</mixed-citation>
</ref>
<ref id="B66"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Katagiri</surname>
<given-names>K.</given-names>
</name>
<name><surname>Yoshida</surname>
<given-names>T.</given-names>
</name>
<name><surname>Sato</surname>
<given-names>K.</given-names>
</name>
</person-group>
(<year>1975</year>
). <article-title>“Quinoxaline antibiotics,” in</article-title>
<source><italic>Antibiotics Mechanism of Action of Antimicrobial and Antitumour Agents</italic>
</source>
, <role>eds</role>
<person-group person-group-type="editor"><name><surname>Corcoran</surname>
<given-names>J. W.</given-names>
</name>
<name><surname>Hahn</surname>
<given-names>F. E.</given-names>
</name>
</person-group>
(<publisher-loc>Heidelberg</publisher-loc>
: <publisher-name>Springer-Verlag</publisher-name>
), <fpage>234</fpage>
–<lpage>251</lpage>
.</mixed-citation>
</ref>
<ref id="B67"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kekuda</surname>
<given-names>T. P.</given-names>
</name>
<name><surname>Shobha</surname>
<given-names>K. S.</given-names>
</name>
<name><surname>Onkarappa</surname>
<given-names>R.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Fascinating diversity and potent biological activities of actinomycete metabolites.</article-title>
<source><italic>J. Pharm. Res.</italic>
</source>
<volume>3</volume>
<fpage>250</fpage>
–<lpage>256</lpage>
.</mixed-citation>
</ref>
<ref id="B68"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Khianngam</surname>
<given-names>S.</given-names>
</name>
<name><surname>Techakriengkrai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Raksasiri</surname>
<given-names>B. V.</given-names>
</name>
<name><surname>Kanjanamaneesathian</surname>
<given-names>M.</given-names>
</name>
<name><surname>Tanasupawat</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>“Isolation and screening of endophytic bacteria for hydrolytic enzymes from plant in mangrove forest at Pranburi, Prachuap Khiri Khan, Thailand,” in</article-title>
<source><italic>Proceedings of the 5th International Symposium on Plant Protection and Plant Health in Europe: Endophytes for plant protection: the state of the art</italic>
</source>
, (<publisher-loc>Berlin</publisher-loc>
: <publisher-name>Humboldt University Berlin</publisher-name>
).</mixed-citation>
</ref>
<ref id="B69"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname>
<given-names>N.</given-names>
</name>
<name><surname>Shin</surname>
<given-names>J. C.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>W.</given-names>
</name>
<name><surname>Hwang</surname>
<given-names>B. Y.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>B. S.</given-names>
</name>
<name><surname>Hong</surname>
<given-names>Y. S.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2006</year>
). <article-title>Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>59</volume>
<fpage>797</fpage>
–<lpage>800</lpage>
. <pub-id pub-id-type="doi">10.1038/ja.2006.105</pub-id>
<pub-id pub-id-type="pmid">17323647</pub-id>
</mixed-citation>
</ref>
<ref id="B70"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Koskimäki</surname>
<given-names>J. J.</given-names>
</name>
<name><surname>Pirttilä</surname>
<given-names>A. M.</given-names>
</name>
<name><surname>Ihantola</surname>
<given-names>E. L.</given-names>
</name>
<name><surname>Halonen</surname>
<given-names>O.</given-names>
</name>
<name><surname>Frank</surname>
<given-names>A. C.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>The intracellular scots pine shoot symbiont <italic>Methylobacterium extorquens</italic>
DSM13060 aggregates around the host nucleus and encodes eukaryote-like proteins.</article-title>
<source><italic>mBio</italic>
</source>
<volume>6</volume>
:<fpage>e39</fpage>
–<lpage>15</lpage>
. <pub-id pub-id-type="doi">10.1128/mBio.00039-15</pub-id>
<pub-id pub-id-type="pmid">25805725</pub-id>
</mixed-citation>
</ref>
<ref id="B71"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname>
<given-names>H.</given-names>
</name>
<name><surname>Soares</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Torres</surname>
<given-names>M. S.</given-names>
</name>
<name><surname>Bergen</surname>
<given-names>M.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Endophytic bacterium, <italic>Bacillus amyloliquefaciens</italic>
, enhances ornamental hosta resistance to diseases and insect pests.</article-title>
<source><italic>J. Plant Interact.</italic>
</source>
<volume>10</volume>
<fpage>224</fpage>
–<lpage>229</lpage>
. <pub-id pub-id-type="doi">10.1080/17429145.2015.1056261</pub-id>
</mixed-citation>
</ref>
<ref id="B72"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>B.</given-names>
</name>
<name><surname>Huang</surname>
<given-names>L.</given-names>
</name>
<name><surname>Buchenauer</surname>
<given-names>H.</given-names>
</name>
<name><surname>Kang</surname>
<given-names>Z.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Isolation and partial characterization of an antifungal protein from the endophytic Bacillus subtilis strain EDR4.</article-title>
<source><italic>Pesticide Biochem. Physiol.</italic>
</source>
<volume>98</volume>
<fpage>305</fpage>
–<lpage>311</lpage>
. <pub-id pub-id-type="doi">10.1016/j.pestbp.2010.07.001</pub-id>
</mixed-citation>
</ref>
<ref id="B73"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>Z.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Jia</surname>
<given-names>X.</given-names>
</name>
<name><surname>Lu</surname>
<given-names>W.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Isolation of secondary metabolites with antimicrobial activities from <italic>Bacillus amyloliquefaciens</italic>
LWYZ003.</article-title>
<source><italic>Trans. Tianjin Univ.</italic>
</source>
<volume>25</volume>
<fpage>38</fpage>
–<lpage>44</lpage>
. <pub-id pub-id-type="doi">10.1016/j.jgar.2017.08.008</pub-id>
<pub-id pub-id-type="pmid">28844975</pub-id>
</mixed-citation>
</ref>
<ref id="B74"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lodewyckx</surname>
<given-names>C.</given-names>
</name>
<name><surname>Vangronsveld</surname>
<given-names>J.</given-names>
</name>
<name><surname>Porteous</surname>
<given-names>F.</given-names>
</name>
<name><surname>Moore</surname>
<given-names>E. R. B.</given-names>
</name>
<name><surname>Taghavi</surname>
<given-names>S.</given-names>
</name>
<name><surname>Mezgeay</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2002</year>
). <article-title>Endophytic bacteria and their potential applications.</article-title>
<source><italic>Crit. Rev. Plant Sci.</italic>
</source>
<volume>21</volume>
<fpage>583</fpage>
–<lpage>606</lpage>
. <pub-id pub-id-type="doi">10.1080/0735-260291044377</pub-id>
</mixed-citation>
</ref>
<ref id="B75"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lòpez-Fernàndez</surname>
<given-names>S.</given-names>
</name>
<name><surname>Compant</surname>
<given-names>S.</given-names>
</name>
<name><surname>Vrhovsek</surname>
<given-names>U.</given-names>
</name>
<name><surname>Bianchedi</surname>
<given-names>P. L.</given-names>
</name>
<name><surname>Sessitsch</surname>
<given-names>A.</given-names>
</name>
<name><surname>Pertot</surname>
<given-names>I.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2016</year>
). <article-title>Grapevine colonization by endophytic bacteria shifts secondary metabolism and suggests activation of defense pathways.</article-title>
<source><italic>Plant Soil</italic>
</source>
<volume>405</volume>
<fpage>155</fpage>
–<lpage>175</lpage>
. <pub-id pub-id-type="doi">10.1007/s11104-015-2631-1</pub-id>
</mixed-citation>
</ref>
<ref id="B76"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname>
<given-names>C.</given-names>
</name>
<name><surname>Shen</surname>
<given-names>Y.</given-names>
</name>
</person-group>
(<year>2003</year>
). <article-title>A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of <italic>Maytenus hookeri</italic>
.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>56</volume>
<fpage>415</fpage>
–<lpage>418</lpage>
. <pub-id pub-id-type="doi">10.7164/antibiotics.56.415</pub-id>
<pub-id pub-id-type="pmid">12817815</pub-id>
</mixed-citation>
</ref>
<ref id="B77"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Luo</surname>
<given-names>S.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>T.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>L.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Rao</surname>
<given-names>C.</given-names>
</name>
<name><surname>Xiao</surname>
<given-names>X.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2012</year>
). <article-title>Endophyte-assisted promotion of biomass production and metal-uptake of energy crop sweet sorghum by plant-growth-promoting endophyte Bacillus sp. SLS18.</article-title>
<source><italic>Appl. Microbiol. Biotechnol.</italic>
</source>
<volume>93</volume>
<fpage>1745</fpage>
–<lpage>1753</lpage>
. <pub-id pub-id-type="doi">10.1007/s00253-011-3483-0</pub-id>
<pub-id pub-id-type="pmid">21792590</pub-id>
</mixed-citation>
</ref>
<ref id="B78"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Manikprabhu</surname>
<given-names>D.</given-names>
</name>
<name><surname>Li</surname>
<given-names>W. J.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>“Antimicrobial agents from actinomycetes Chemistry and Applications,” in</article-title>
<source><italic>Antimicrobials Synthetic and Natural Compounds</italic>
</source>
, <role>eds</role>
<person-group person-group-type="editor"><name><surname>Dhanasekaran</surname>
<given-names>D.</given-names>
</name>
<name><surname>Thajuddin</surname>
<given-names>N.</given-names>
</name>
<name><surname>Panneerselvam</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<publisher-loc>Milton Park</publisher-loc>
: <publisher-name>Taylor & Francis Group</publisher-name>
), <fpage>99</fpage>
–<lpage>115</lpage>
.</mixed-citation>
</ref>
<ref id="B79"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matsumoto</surname>
<given-names>A.</given-names>
</name>
<name><surname>Takahashi</surname>
<given-names>Y.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Endophytic actinomycetes: promising source of novel bioactive compounds.</article-title>
<source><italic>J. Antibiot.</italic>
</source>
<volume>70</volume>
<fpage>514</fpage>
–<lpage>519</lpage>
. <pub-id pub-id-type="doi">10.1038/ja.2017.20</pub-id>
<pub-id pub-id-type="pmid">28270688</pub-id>
</mixed-citation>
</ref>
<ref id="B80"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mingma</surname>
<given-names>R.</given-names>
</name>
<name><surname>Pathom-aree</surname>
<given-names>W.</given-names>
</name>
<name><surname>Trakulnaleamsai</surname>
<given-names>S.</given-names>
</name>
<name><surname>Thamchaipenet</surname>
<given-names>A.</given-names>
</name>
<name><surname>Duangmal</surname>
<given-names>K.</given-names>
</name>
</person-group>
(<year>2014</year>
). <article-title>Isolation of rhizospheric and roots endophytic actinomycetes from leguminosae plant and their activities to inhibit soybean pathogen. Xanthomonas campestris pv. glycine.</article-title>
<source><italic>World J. Microbiol. Biotechnol.</italic>
</source>
<volume>30</volume>
<fpage>271</fpage>
–<lpage>280</lpage>
. <pub-id pub-id-type="doi">10.1007/s11274-013-1451-9</pub-id>
<pub-id pub-id-type="pmid">23913026</pub-id>
</mixed-citation>
</ref>
<ref id="B81"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mohamad</surname>
<given-names>O. A.</given-names>
</name>
<name><surname>Li</surname>
<given-names>L.</given-names>
</name>
<name><surname>Ma</surname>
<given-names>J. B.</given-names>
</name>
<name><surname>Hatab</surname>
<given-names>S.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>L.</given-names>
</name>
<name><surname>Guo</surname>
<given-names>J. W.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Evaluation of the antimicrobial activity of endophytic bacterial populations from Chinese traditional medicinal plant licorice and characterization of the bioactive secondary metabolites produced by <italic>Bacillus atrophaeus</italic>
against <italic>Verticillium dahliae</italic>
.</article-title>
<source><italic>Front. Microbiol.</italic>
</source>
<volume>9</volume>
:<issue>924</issue>
. <pub-id pub-id-type="doi">10.3389/fmicb.2018.00924</pub-id>
<pub-id pub-id-type="pmid">29867835</pub-id>
</mixed-citation>
</ref>
<ref id="B82"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nautiyal</surname>
<given-names>C. S.</given-names>
</name>
<name><surname>Srivastava</surname>
<given-names>S.</given-names>
</name>
<name><surname>Chauhan</surname>
<given-names>P. S.</given-names>
</name>
<name><surname>Seem</surname>
<given-names>K.</given-names>
</name>
<name><surname>Mishra</surname>
<given-names>A.</given-names>
</name>
<name><surname>Sopory</surname>
<given-names>S. K.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Plant growth-promoting bacteria <italic>Bacillus amyloliquefaciens</italic>
NBRISN13 modulates gene expression profile of leaf and rhizosphere community in rice during salt stress.</article-title>
<source><italic>Plant Physiol. Biochem.</italic>
</source>
<volume>66</volume>
<fpage>1</fpage>
–<lpage>9</lpage>
. <pub-id pub-id-type="doi">10.1016/j.plaphy.2013.01.020</pub-id>
<pub-id pub-id-type="pmid">23454292</pub-id>
</mixed-citation>
</ref>
<ref id="B83"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nehra</surname>
<given-names>V.</given-names>
</name>
<name><surname>Saharan</surname>
<given-names>B. S.</given-names>
</name>
<name><surname>Choudhary</surname>
<given-names>M.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Evaluation of Brevibacillus brevis as a potential plant growth promoting rhizobacteria for cotton (Gossypium hirsutum) crop.</article-title>
<source><italic>SpringerPlus</italic>
</source>
<volume>5</volume>
:<issue>948</issue>
. <pub-id pub-id-type="doi">10.1186/s40064-016-2584-8</pub-id>
<pub-id pub-id-type="pmid">27386392</pub-id>
</mixed-citation>
</ref>
<ref id="B84"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ongena</surname>
<given-names>M.</given-names>
</name>
<name><surname>Jacques</surname>
<given-names>P.</given-names>
</name>
</person-group>
(<year>2008</year>
). <article-title>Bacillus lipopeptides: versatile weapons for plant disease biocontrol.</article-title>
<source><italic>Trends Microbiol.</italic>
</source>
<volume>16</volume>
<fpage>115</fpage>
–<lpage>125</lpage>
. <pub-id pub-id-type="doi">10.1016/j.tim.2007.12.009</pub-id>
<pub-id pub-id-type="pmid">18289856</pub-id>
</mixed-citation>
</ref>
<ref id="B85"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Pandey</surname>
<given-names>P. K.</given-names>
</name>
<name><surname>Singh</surname>
<given-names>S.</given-names>
</name>
<name><surname>Singh</surname>
<given-names>M. C.</given-names>
</name>
<name><surname>Singh</surname>
<given-names>A. K.</given-names>
</name>
<name><surname>Yadav</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Pandey</surname>
<given-names>A. K.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>“Diversity, ecology, and conservation of fungal and bacterial endophytes,” in</article-title>
<source><italic>Microbial Resource Conservation</italic>
</source>
, <role>eds</role>
<person-group person-group-type="editor"><name><surname>Sharma</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Varma</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<publisher-loc>New York, NY</publisher-loc>
: <publisher-name>Springer International Publishing</publisher-name>
), <fpage>393</fpage>
–<lpage>430</lpage>
.</mixed-citation>
</ref>
<ref id="B86"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paungfoo-Lonhienne</surname>
<given-names>C.</given-names>
</name>
<name><surname>Rentsch</surname>
<given-names>D.</given-names>
</name>
<name><surname>Robatzek</surname>
<given-names>S.</given-names>
</name>
<name><surname>Webb</surname>
<given-names>R. I.</given-names>
</name>
<name><surname>Sagulenko</surname>
<given-names>E.</given-names>
</name>
<name><surname>Näsholm</surname>
<given-names>T.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2010</year>
). <article-title>Turning the table: plants consume microbes as a source of nutrients.</article-title>
<source><italic>PLoS One</italic>
</source>
<volume>5</volume>
:<issue>e11915</issue>
. <pub-id pub-id-type="doi">10.1371/journal.pone.0011915</pub-id>
<pub-id pub-id-type="pmid">20689833</pub-id>
</mixed-citation>
</ref>
<ref id="B87"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peña-Yam</surname>
<given-names>L. P.</given-names>
</name>
<name><surname>Ruíz-Sánchez</surname>
<given-names>E.</given-names>
</name>
<name><surname>Barboza-Corona</surname>
<given-names>J. E.</given-names>
</name>
<name><surname>Reyes-Ramírez</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Isolation of mexican bacillus species and their effects in promoting growth of chili pepper (<italic>Capsicum annuum</italic>
L. cv Jalapeño).</article-title>
<source><italic>Indian J. Microbiol.</italic>
</source>
<volume>56</volume>
<fpage>375</fpage>
–<lpage>378</lpage>
. <pub-id pub-id-type="doi">10.1007/s12088-016-0582-8</pub-id>
<pub-id pub-id-type="pmid">27407303</pub-id>
</mixed-citation>
</ref>
<ref id="B88"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pieterse</surname>
<given-names>C. M. J.</given-names>
</name>
<name><surname>Zamioudis</surname>
<given-names>C.</given-names>
</name>
<name><surname>Berendsen</surname>
<given-names>R. L.</given-names>
</name>
<name><surname>Weller</surname>
<given-names>D. M.</given-names>
</name>
<name><surname>Van Wees</surname>
<given-names>S. C. M.</given-names>
</name>
<name><surname>Bakker</surname>
<given-names>P. A. H. M.</given-names>
</name>
</person-group>
(<year>2014</year>
). <article-title>Induced systemic resistance by beneficial microbes.</article-title>
<source><italic>Ann. Rev. Phytopathol.</italic>
</source>
<volume>52</volume>
<fpage>347</fpage>
–<lpage>375</lpage>
. <pub-id pub-id-type="doi">10.1146/annurev-phyto-082712-102340</pub-id>
<pub-id pub-id-type="pmid">24906124</pub-id>
</mixed-citation>
</ref>
<ref id="B89"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Posada</surname>
<given-names>L. F.</given-names>
</name>
<name><surname>Álvarez</surname>
<given-names>J. C.</given-names>
</name>
<name><surname>Romero-Tabarez</surname>
<given-names>M.</given-names>
</name>
<name><surname>de-Bashan</surname>
<given-names>L.</given-names>
</name>
<name><surname>Villegas-Escobar</surname>
<given-names>V.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Enhanced molecular visualization of root colonization and growth promotion by bacillus subtilis EA-CB0575 in different growth systems.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>217</volume>
<fpage>69</fpage>
–<lpage>80</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2018.08.017</pub-id>
<pub-id pub-id-type="pmid">30384910</pub-id>
</mixed-citation>
</ref>
<ref id="B90"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pratiwi</surname>
<given-names>R. H.</given-names>
</name>
<name><surname>Hanafi</surname>
<given-names>M.</given-names>
</name>
<name><surname>Artanti</surname>
<given-names>N.</given-names>
</name>
<name><surname>Pratiwi</surname>
<given-names>R. D.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Bioactivity of antibacterial compounds produced by endophytic actinomycetes from <italic>Neesia altissima</italic>
.</article-title>
<source><italic>J. Trop. Life Sci.</italic>
</source>
<volume>8</volume>
<fpage>37</fpage>
–<lpage>42</lpage>
. <pub-id pub-id-type="doi">10.11594/jtls.08.01.07</pub-id>
</mixed-citation>
</ref>
<ref id="B91"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Qin</surname>
<given-names>S.</given-names>
</name>
<name><surname>Xing</surname>
<given-names>K.</given-names>
</name>
<name><surname>Jiang</surname>
<given-names>J. H.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>L. H.</given-names>
</name>
<name><surname>Li</surname>
<given-names>W. J.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Biodiversity, bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria.</article-title>
<source><italic>Appl. Microbiol. Biotechnol.</italic>
</source>
<volume>89</volume>
<fpage>457</fpage>
–<lpage>473</lpage>
. <pub-id pub-id-type="doi">10.1007/s00253-010-2923-6</pub-id>
<pub-id pub-id-type="pmid">20941490</pub-id>
</mixed-citation>
</ref>
<ref id="B92"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raaijmakers</surname>
<given-names>J. M.</given-names>
</name>
<name><surname>de Bruijn</surname>
<given-names>I.</given-names>
</name>
<name><surname>Nybroe</surname>
<given-names>O.</given-names>
</name>
<name><surname>Ongena</surname>
<given-names>M.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Natural functions of lipopeptides from Bacillus and <italic>Pseudomonas</italic>
: more than surfactants and antibiotics.</article-title>
<source><italic>FEMS Microbiol. Rev.</italic>
</source>
<volume>34</volume>
<fpage>1037</fpage>
–<lpage>1062</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1574-6976.2010.00221.x</pub-id>
<pub-id pub-id-type="pmid">20412310</pub-id>
</mixed-citation>
</ref>
<ref id="B93"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rado</surname>
<given-names>R.</given-names>
</name>
<name><surname>Andrianarisoa</surname>
<given-names>B.</given-names>
</name>
<name><surname>Ravelomanantsoa</surname>
<given-names>S.</given-names>
</name>
<name><surname>Rakotoarimanga</surname>
<given-names>N.</given-names>
</name>
<name><surname>Rahetlah</surname>
<given-names>V.</given-names>
</name>
<name><surname>Fienena</surname>
<given-names>F. R.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>Biocontrol of potato wilt by selective rhizospheric and endophytic bacteria associated with potato plant.</article-title>
<source><italic>Afr. J. Food Agric. Nutr. Dev.</italic>
</source>
<volume>15</volume>
<fpage>9762</fpage>
–<lpage>9776</lpage>
.</mixed-citation>
</ref>
<ref id="B94"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramamoorthy</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gnanakan</surname>
<given-names>A.</given-names>
</name>
<name><surname>Lakshmana</surname>
<given-names>S. S.</given-names>
</name>
<name><surname>Meivelu</surname>
<given-names>M.</given-names>
</name>
<name><surname>Jeganathan</surname>
<given-names>A.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Structural characterization and anticancer activity of extracellular polysaccharides from ascidian symbiotic bacterium <italic>Bacillus thuringiensis</italic>
.</article-title>
<source><italic>Carbohydrate Pol.</italic>
</source>
<volume>190</volume>
<fpage>113</fpage>
–<lpage>120</lpage>
. <pub-id pub-id-type="doi">10.1016/j.carbpol.2018.02.047</pub-id>
<pub-id pub-id-type="pmid">29628227</pub-id>
</mixed-citation>
</ref>
<ref id="B95"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reinhold-Hurek</surname>
<given-names>B.</given-names>
</name>
<name><surname>Hurek</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>2011</year>
). <article-title>Living inside plants: bacterial endophytes.</article-title>
<source><italic>Curr. Opin. Plant Biol.</italic>
</source>
<volume>14</volume>
<fpage>435</fpage>
–<lpage>443</lpage>
. <pub-id pub-id-type="doi">10.1016/j.pbi.2011.04.004</pub-id>
<pub-id pub-id-type="pmid">21536480</pub-id>
</mixed-citation>
</ref>
<ref id="B96"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renu</surname>
<given-names>S.</given-names>
</name>
<name><surname>Monisha</surname>
<given-names>K.</given-names>
</name>
<name><surname>Lal</surname>
<given-names>R.</given-names>
</name>
</person-group>
(<year>2008</year>
). <article-title>Bioactive compounds from marine actinomycetes.</article-title>
<source><italic>Indian J. Microb.</italic>
</source>
<volume>48</volume>
<fpage>410</fpage>
–<lpage>431</lpage>
. <pub-id pub-id-type="doi">10.1007/s12088-008-0052-z</pub-id>
<pub-id pub-id-type="pmid">23100742</pub-id>
</mixed-citation>
</ref>
<ref id="B97"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rosenblueth</surname>
<given-names>M.</given-names>
</name>
<name><surname>Martínez-Romero</surname>
<given-names>E.</given-names>
</name>
</person-group>
(<year>2006</year>
). <article-title>Bacterial endophytes and their interactions with hosts.</article-title>
<source><italic>Mol. Plant Microbe Interact.</italic>
</source>
<volume>19</volume>
<fpage>827</fpage>
–<lpage>837</lpage>
. <pub-id pub-id-type="doi">10.1094/MPMI-19-0827</pub-id>
<pub-id pub-id-type="pmid">16903349</pub-id>
</mixed-citation>
</ref>
<ref id="B98"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ryan</surname>
<given-names>R. P.</given-names>
</name>
<name><surname>Germaine</surname>
<given-names>K.</given-names>
</name>
<name><surname>Franks</surname>
<given-names>A.</given-names>
</name>
<name><surname>Ryan</surname>
<given-names>D. J.</given-names>
</name>
<name><surname>Dowling</surname>
<given-names>D. N.</given-names>
</name>
</person-group>
(<year>2008</year>
). <article-title>Bacterial endophytes: recent developments and applications.</article-title>
<source><italic>FEMS Microbiol. Lett.</italic>
</source>
<volume>278</volume>
<fpage>1</fpage>
–<lpage>9</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1574-6968.2007.00918.x</pub-id>
<pub-id pub-id-type="pmid">18034833</pub-id>
</mixed-citation>
</ref>
<ref id="B99"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sabaté</surname>
<given-names>D. C.</given-names>
</name>
<name><surname>Brandan</surname>
<given-names>C. P.</given-names>
</name>
<name><surname>Petroselli</surname>
<given-names>G.</given-names>
</name>
<name><surname>Erra-Balsells</surname>
<given-names>R.</given-names>
</name>
<name><surname>Audisio</surname>
<given-names>M. C.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Biocontrol of Sclerotinia sclerotiorum (Lib.) de Bary on common bean by native lipopeptide-producer Bacillus strains.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>211</volume>
<fpage>21</fpage>
–<lpage>30</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2018.04.003</pub-id>
<pub-id pub-id-type="pmid">29705203</pub-id>
</mixed-citation>
</ref>
<ref id="B100"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Safiyazov</surname>
<given-names>J. S.</given-names>
</name>
<name><surname>Mannanov</surname>
<given-names>R. N.</given-names>
</name>
<name><surname>Sattarova</surname>
<given-names>R. K.</given-names>
</name>
</person-group>
(<year>1995</year>
). <article-title>The use of bacterial antagonists for the control of cotton disease.</article-title>
<source><italic>Field Crops Res.</italic>
</source>
<volume>43</volume>
<fpage>51</fpage>
–<lpage>54</lpage>
. <pub-id pub-id-type="doi">10.1016/0378-4290(95)00038-R</pub-id>
</mixed-citation>
</ref>
<ref id="B101"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Santoyo</surname>
<given-names>G.</given-names>
</name>
<name><surname>Moreno-Hagelsieb</surname>
<given-names>G.</given-names>
</name>
<name><surname>del Orozco-Mosqueda</surname>
<given-names>M. C.</given-names>
</name>
<name><surname>Glick</surname>
<given-names>B. R.</given-names>
</name>
</person-group>
(<year>2016</year>
). <article-title>Plant growth-promoting bacterial endophytes.</article-title>
<source><italic>Microbiol. Res.</italic>
</source>
<volume>183</volume>
<fpage>92</fpage>
–<lpage>99</lpage>
. <pub-id pub-id-type="doi">10.1016/j.micres.2015.11.008</pub-id>
<pub-id pub-id-type="pmid">26805622</pub-id>
</mixed-citation>
</ref>
<ref id="B102"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schulz</surname>
<given-names>B.</given-names>
</name>
<name><surname>Boyle</surname>
<given-names>C.</given-names>
</name>
</person-group>
(<year>2006</year>
). <article-title>What are endophytes?</article-title>
<source><italic>Soil Biol.</italic>
</source>
<volume>9</volume>
<fpage>1</fpage>
–<lpage>14</lpage>
. <pub-id pub-id-type="doi">10.1007/3-540-33526-9_1</pub-id>
</mixed-citation>
</ref>
<ref id="B103"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Selvakumar</surname>
<given-names>G.</given-names>
</name>
<name><surname>Kundu</surname>
<given-names>S.</given-names>
</name>
<name><surname>Joshi</surname>
<given-names>P.</given-names>
</name>
<name><surname>Nazim</surname>
<given-names>S.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>A. D.</given-names>
</name>
<name><surname>Gupta</surname>
<given-names>H. S.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Growth promotion of wheat seedlings by exiguobacterium acetylicum 1P (MTCC 8707) a cold tolerant bacterial strain from the uttarakhand himalayas.</article-title>
<source><italic>Indian J. Microbiol.</italic>
</source>
<volume>50</volume>
<fpage>50</fpage>
–<lpage>56</lpage>
. <pub-id pub-id-type="doi">10.1007/s12088-009-0024-y</pub-id>
<pub-id pub-id-type="pmid">23100807</pub-id>
</mixed-citation>
</ref>
<ref id="B104"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seo</surname>
<given-names>W. T.</given-names>
</name>
<name><surname>Lim</surname>
<given-names>W. J.</given-names>
</name>
<name><surname>Kim</surname>
<given-names>E. J.</given-names>
</name>
<name><surname>Yun</surname>
<given-names>H. D.</given-names>
</name>
<name><surname>Lee</surname>
<given-names>Y. H.</given-names>
</name>
<name><surname>Cho</surname>
<given-names>K. M.</given-names>
</name>
</person-group>
(<year>2010</year>
). <article-title>Endophytic bacterial diversity in the young radish and their antimicrobial activity against pathogens.</article-title>
<source><italic>J. Korean Soc. Appl. Biol. Chem.</italic>
</source>
<volume>53</volume>
<fpage>493</fpage>
–<lpage>503</lpage>
. <pub-id pub-id-type="doi">10.3839/jksabc.2010.075</pub-id>
</mixed-citation>
</ref>
<ref id="B105"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shahzad</surname>
<given-names>R.</given-names>
</name>
<name><surname>Waqas</surname>
<given-names>M.</given-names>
</name>
<name><surname>Khan</surname>
<given-names>A. L.</given-names>
</name>
<name><surname>Asaf</surname>
<given-names>S.</given-names>
</name>
<name><surname>Khan</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Kang</surname>
<given-names>S. M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2016</year>
). <article-title>Seed-borne endophytic <italic>Bacillus amyloliquefaciens</italic>
RWL-1 produces gibberellins and regulates endogenous phytohormones of <italic>Oryza sativa</italic>
.</article-title>
<source><italic>Plant Physiol. Biochem.</italic>
</source>
<volume>106</volume>
<fpage>236</fpage>
–<lpage>243</lpage>
. <pub-id pub-id-type="doi">10.1016/j.plaphy.2016.05.006</pub-id>
<pub-id pub-id-type="pmid">27182958</pub-id>
</mixed-citation>
</ref>
<ref id="B106"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shimizu</surname>
<given-names>M.</given-names>
</name>
<name><surname>Nakagawa</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Yukio</surname>
<given-names>S. A. T. O.</given-names>
</name>
<name><surname>Furumai</surname>
<given-names>T.</given-names>
</name>
<name><surname>Igarashi</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Onaka</surname>
<given-names>H.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2000</year>
). <article-title>Studies on endophytic actinomycetes (I) Streptomyces sp. Isolated from rhododendron and its antifungal activity.</article-title>
<source><italic>J. Gen. Plant Pathol.</italic>
</source>
<volume>66</volume>
<fpage>360</fpage>
–<lpage>366</lpage>
. <pub-id pub-id-type="doi">10.1007/PL00012978</pub-id>
</mixed-citation>
</ref>
<ref id="B107"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stein</surname>
<given-names>T.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Bacillus subtilis antibiotics: structures, syntheses and specific functions.</article-title>
<source><italic>Mol. Microbiol.</italic>
</source>
<volume>56</volume>
<fpage>845</fpage>
–<lpage>857</lpage>
. <pub-id pub-id-type="doi">10.1111/j.1365-2958.2005.04587.x</pub-id>
<pub-id pub-id-type="pmid">15853875</pub-id>
</mixed-citation>
</ref>
<ref id="B108"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Strobel</surname>
<given-names>G. A.</given-names>
</name>
<name><surname>Daisy</surname>
<given-names>B.</given-names>
</name>
</person-group>
(<year>2003</year>
). <article-title>Bioprospecting for microbial endophytes and their natural products.</article-title>
<source><italic>Microbiol. Mol. Biol. Rev.</italic>
</source>
<volume>67</volume>
<fpage>491</fpage>
–<lpage>502</lpage>
. <pub-id pub-id-type="doi">10.1128/MMBR.67.4.491-502.2003</pub-id>
<pub-id pub-id-type="pmid">14665674</pub-id>
</mixed-citation>
</ref>
<ref id="B109"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sziderics</surname>
<given-names>A. H.</given-names>
</name>
<name><surname>Rasche</surname>
<given-names>F.</given-names>
</name>
<name><surname>Trognitz</surname>
<given-names>F.</given-names>
</name>
<name><surname>Sessitsch</surname>
<given-names>A.</given-names>
</name>
<name><surname>Wilhelm</surname>
<given-names>E.</given-names>
</name>
</person-group>
(<year>2007</year>
). <article-title>Bacterial endophytes contribute to abiotic stress adaptation in pepper plants (<italic>Capsicum annuum</italic>
L.).</article-title>
<source><italic>Can. J. Microbiol.</italic>
</source>
<volume>53</volume>
<fpage>1195</fpage>
–<lpage>1202</lpage>
. <pub-id pub-id-type="doi">10.1139/W07-082</pub-id>
<pub-id pub-id-type="pmid">18026213</pub-id>
</mixed-citation>
</ref>
<ref id="B110"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Taechowisan</surname>
<given-names>T.</given-names>
</name>
<name><surname>Chaisaeng</surname>
<given-names>S.</given-names>
</name>
<name><surname>Phutdhawong</surname>
<given-names>W. S.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>Antibacterial, antioxidant and anticancer activities of biphenyls from Streptomyces sp. BO-07: an endophyte in <italic>Boesenbergia rotunda</italic>
(L.) Mansf A.</article-title>
<source><italic>Food Agric. Immunol.</italic>
</source>
<volume>28</volume>
<fpage>1330</fpage>
–<lpage>1346</lpage>
. <pub-id pub-id-type="doi">10.1080/09540105.2017.1339669</pub-id>
</mixed-citation>
</ref>
<ref id="B111"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Taechowisan</surname>
<given-names>T.</given-names>
</name>
<name><surname>Chanaphat</surname>
<given-names>S.</given-names>
</name>
<name><surname>Ruensamran</surname>
<given-names>W.</given-names>
</name>
<name><surname>Phutdhawong</surname>
<given-names>W. S.</given-names>
</name>
</person-group>
(<year>2013</year>
). <article-title>Antibacterial activity of decursin from streptomyces sp. GMT-8; an endophyte in zingiber officinale rosc.</article-title>
<source><italic>J. Appl. Pharm. Sci.</italic>
</source>
<volume>3</volume>
<fpage>74</fpage>
–<lpage>78</lpage>
.</mixed-citation>
</ref>
<ref id="B112"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Taechowisan</surname>
<given-names>T. C.</given-names>
</name>
<name><surname>Lu</surname>
<given-names>C. H.</given-names>
</name>
<name><surname>Shen</surname>
<given-names>Y. M.</given-names>
</name>
<name><surname>Lumyong</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2007</year>
). <article-title>Antitumor activity of 4-arylcoumarins from endophytic <italic>Streptomyces aureofaciens</italic>
CMUAc130.</article-title>
<source><italic>J. Cancer Res. Ther.</italic>
</source>
<volume>3</volume>
<fpage>86</fpage>
–<lpage>91</lpage>
. <pub-id pub-id-type="doi">10.4103/0973-1482.34685</pub-id>
<pub-id pub-id-type="pmid">17998729</pub-id>
</mixed-citation>
</ref>
<ref id="B113"><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Tamosiune</surname>
<given-names>I.</given-names>
</name>
<name><surname>Baniulis</surname>
<given-names>D.</given-names>
</name>
<name><surname>Stanys</surname>
<given-names>V.</given-names>
</name>
</person-group>
(<year>2017</year>
). <article-title>“Role of endophytic bacteria in stress tolerance of agricultural plants: diversity of microorganisms and molecular mechanisms,” in</article-title>
<source><italic>Probiotics in Agroecosystem</italic>
</source>
, <role>eds</role>
<person-group person-group-type="editor"><name><surname>Kumar</surname>
<given-names>V.</given-names>
</name>
<name><surname>Kumar</surname>
<given-names>M.</given-names>
</name>
<name><surname>Sharma</surname>
<given-names>S.</given-names>
</name>
<name><surname>Prasad</surname>
<given-names>R.</given-names>
</name>
</person-group>
(<publisher-loc>Singapore</publisher-loc>
: <publisher-name>Springer</publisher-name>
).</mixed-citation>
</ref>
<ref id="B114"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tian</surname>
<given-names>B.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>C.</given-names>
</name>
<name><surname>Ye</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Wen</surname>
<given-names>J.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Wang</surname>
<given-names>H.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2017</year>
). <article-title>Beneficial traits of bacterial endophytes belonging to the core communities of the tomato root microbiome.</article-title>
<source><italic>Agric. Ecosys. Environ.</italic>
</source>
<volume>247</volume>
<fpage>149</fpage>
–<lpage>156</lpage>
. <pub-id pub-id-type="doi">10.1016/j.agee.2017.06.041</pub-id>
</mixed-citation>
</ref>
<ref id="B115"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tripathi</surname>
<given-names>V. C.</given-names>
</name>
<name><surname>Satish</surname>
<given-names>S.</given-names>
</name>
<name><surname>Horam</surname>
<given-names>S.</given-names>
</name>
<name><surname>Raj</surname>
<given-names>S.</given-names>
</name>
<name><surname>Arockiaraj</surname>
<given-names>J.</given-names>
</name>
<name><surname>Pasupuleti</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Natural products from polar organisms: structural diversity, bioactivities and potential pharmaceutical applications.</article-title>
<source><italic>Polar Sci.</italic>
</source>
<volume>18</volume>
<fpage>147</fpage>
–<lpage>166</lpage>
. <pub-id pub-id-type="doi">10.1016/j.polar.2018.04.006</pub-id>
</mixed-citation>
</ref>
<ref id="B116"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsurumaru</surname>
<given-names>H.</given-names>
</name>
<name><surname>Okubo</surname>
<given-names>T.</given-names>
</name>
<name><surname>Okazaki</surname>
<given-names>K.</given-names>
</name>
<name><surname>Hashimoto</surname>
<given-names>M.</given-names>
</name>
<name><surname>Kakizaki</surname>
<given-names>K.</given-names>
</name>
<name><surname>Hanzawa</surname>
<given-names>E.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>Metagenomic analysis of the bacterial community associated with the taproot of sugar beet.</article-title>
<source><italic>Microbes Environ.</italic>
</source>
<volume>30</volume>
<fpage>63</fpage>
–<lpage>69</lpage>
. <pub-id pub-id-type="doi">10.1264/jsme2.ME14109</pub-id>
<pub-id pub-id-type="pmid">25740621</pub-id>
</mixed-citation>
</ref>
<ref id="B117"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Verma</surname>
<given-names>P.</given-names>
</name>
<name><surname>Yadav</surname>
<given-names>A. N.</given-names>
</name>
<name><surname>Khannam</surname>
<given-names>K. S.</given-names>
</name>
<name><surname>Panjiar</surname>
<given-names>N.</given-names>
</name>
<name><surname>Kumar</surname>
<given-names>S.</given-names>
</name>
<name><surname>Saxena</surname>
<given-names>A. K.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>Assessment of genetic diversity and plant growth promoting attributes of psychrotolerant bacteria allied with wheat (Triticum aestivum) from the northern hills zone of India.</article-title>
<source><italic>Ann. Microbiol.</italic>
</source>
<volume>65</volume>
<fpage>1885</fpage>
–<lpage>1899</lpage>
. <pub-id pub-id-type="doi">10.1007/s13213-014-1027-4</pub-id>
</mixed-citation>
</ref>
<ref id="B118"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Verma</surname>
<given-names>V. C.</given-names>
</name>
<name><surname>Gond</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Kumar</surname>
<given-names>A.</given-names>
</name>
<name><surname>Mishra</surname>
<given-names>A.</given-names>
</name>
<name><surname>Kharwar</surname>
<given-names>R. N.</given-names>
</name>
<name><surname>Gange</surname>
<given-names>A. C.</given-names>
</name>
</person-group>
(<year>2009</year>
). <article-title>Endophytic actinomycetes from Azadirachta indica A. Juss.: isolation, diversity, and anti-microbial activity.</article-title>
<source><italic>Microb. Ecol.</italic>
</source>
<volume>57</volume>
<fpage>749</fpage>
–<lpage>756</lpage>
. <pub-id pub-id-type="doi">10.1007/s00248-008-9450-3</pub-id>
<pub-id pub-id-type="pmid">18853084</pub-id>
</mixed-citation>
</ref>
<ref id="B119"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Villarreal-Delgado</surname>
<given-names>M. F.</given-names>
</name>
<name><surname>Villa-Rodríguez</surname>
<given-names>E. D.</given-names>
</name>
<name><surname>Cira-Chávez</surname>
<given-names>L. A.</given-names>
</name>
<name><surname>Estrada-Alvarado</surname>
<given-names>M. I</given-names>
</name>
<name><surname>Parra-Cota</surname>
<given-names>F. I.</given-names>
</name>
<name><surname>de los Santos-Villalobos</surname>
<given-names>S.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>The genus bacillus as a biological control agent and its implications in the agricultural biosecurity.</article-title>
<source><italic>Mex. J. Phytopathol.</italic>
</source>
<volume>36</volume>
<fpage>95</fpage>
–<lpage>130</lpage>
.</mixed-citation>
</ref>
<ref id="B120"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vu</surname>
<given-names>H. N. T.</given-names>
</name>
<name><surname>Nguyen</surname>
<given-names>D. T.</given-names>
</name>
<name><surname>Nguyen</surname>
<given-names>H. Q.</given-names>
</name>
<name><surname>Chu</surname>
<given-names>H. H.</given-names>
</name>
<name><surname>Chu</surname>
<given-names>S. K.</given-names>
</name>
<name><surname>Van Chau</surname>
<given-names>M.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Antimicrobial and cytotoxic properties of bioactive metabolites produced by <italic>Streptomyces cavourensis</italic>
YBQ59 isolated from cinnamomum cassia prels in yen bai province of vietnam.</article-title>
<source><italic>Curr. Microbiol.</italic>
</source>
<volume>75</volume>
<fpage>1247</fpage>
–<lpage>1255</lpage>
. <pub-id pub-id-type="doi">10.1007/s00284-018-1517-x</pub-id>
<pub-id pub-id-type="pmid">29869093</pub-id>
</mixed-citation>
</ref>
<ref id="B121"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Waring</surname>
<given-names>M. J.</given-names>
</name>
<name><surname>Wakelin</surname>
<given-names>L. P.</given-names>
</name>
</person-group>
(<year>1974</year>
). <article-title>Echinomycin: abifunctional intercalating antibiotic.</article-title>
<source><italic>Nature</italic>
</source>
<volume>252</volume>
<fpage>653</fpage>
–<lpage>657</lpage>
. <pub-id pub-id-type="doi">10.1038/252653a0</pub-id>
<pub-id pub-id-type="pmid">4437614</pub-id>
</mixed-citation>
</ref>
<ref id="B122"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wei</surname>
<given-names>W.</given-names>
</name>
<name><surname>Zhou</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>F.</given-names>
</name>
<name><surname>Yan</surname>
<given-names>X.</given-names>
</name>
<name><surname>Lai</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Wei</surname>
<given-names>C.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Isolation, diversity, and antimicrobial and immunomodulatory activities of endophytic actinobacteria from tea cultivars Zijuan and Yunkang-10 (Camellia sinensis var. <italic>assamica)</italic>
.</article-title>
<source><italic>Front. Microbiol.</italic>
</source>
<volume>9</volume>
:<issue>1304</issue>
. <pub-id pub-id-type="doi">10.3389/fmicb.2018.01304</pub-id>
<pub-id pub-id-type="pmid">29967601</pub-id>
</mixed-citation>
</ref>
<ref id="B123"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xia</surname>
<given-names>Y.</given-names>
</name>
<name><surname>DeBolt</surname>
<given-names>S.</given-names>
</name>
<name><surname>Dreyer</surname>
<given-names>J.</given-names>
</name>
<name><surname>Scott</surname>
<given-names>D.</given-names>
</name>
<name><surname>Williams</surname>
<given-names>M. A.</given-names>
</name>
</person-group>
(<year>2015</year>
). <article-title>Characterization of culturable bacterial endophytes and their capacity to promote plant growth from plants grown using organic or conventional practices.</article-title>
<source><italic>Front. Plant Sci.</italic>
</source>
<volume>6</volume>
:<issue>490</issue>
. <pub-id pub-id-type="doi">10.3389/fpls.2015.00490</pub-id>
<pub-id pub-id-type="pmid">26217348</pub-id>
</mixed-citation>
</ref>
<ref id="B124"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yuan</surname>
<given-names>J.</given-names>
</name>
<name><surname>Wu</surname>
<given-names>Y.</given-names>
</name>
<name><surname>Zhao</surname>
<given-names>M.</given-names>
</name>
<name><surname>Wen</surname>
<given-names>T.</given-names>
</name>
<name><surname>Huang</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Shen</surname>
<given-names>Q.</given-names>
</name>
</person-group>
(<year>2018</year>
). <article-title>Effect of phenolic acids from banana root exudates on root colonization and pathogen suppressive properties of Bacillus amyloliquefaciens NJN-6.</article-title>
<source><italic>Biol. Control</italic>
</source>
<volume>125</volume>
<fpage>131</fpage>
–<lpage>137</lpage>
. <pub-id pub-id-type="doi">10.1016/j.biocontrol.2018.05.016</pub-id>
</mixed-citation>
</ref>
<ref id="B125"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zeiller</surname>
<given-names>M.</given-names>
</name>
<name><surname>Rothballer</surname>
<given-names>M.</given-names>
</name>
<name><surname>Iwobi</surname>
<given-names>A. N.</given-names>
</name>
<name><surname>Böhnel</surname>
<given-names>H.</given-names>
</name>
<name><surname>Gessler</surname>
<given-names>F.</given-names>
</name>
<name><surname>Hartmann</surname>
<given-names>A.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2015</year>
). <article-title>Systemic colonization of clover (Trifolium repens) by clostridium botulinum strain 2301.</article-title>
<source><italic>Front. Microbiol.</italic>
</source>
<volume>6</volume>
:<issue>1207</issue>
. <pub-id pub-id-type="doi">10.3389/fmicb.2015.01207</pub-id>
<pub-id pub-id-type="pmid">26583010</pub-id>
</mixed-citation>
</ref>
<ref id="B126"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname>
<given-names>K.</given-names>
</name>
<name><surname>Li</surname>
<given-names>J.</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>X.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Liu</surname>
<given-names>M.</given-names>
</name>
<name><surname>Ao</surname>
<given-names>X.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2018</year>
). <article-title>Actinobacteria associated with <italic>Glycyrrhiza inflata</italic>
Bat. Are diverse and have plant growth promoting and antimicrobial activity.</article-title>
<source><italic>Sci. Rep.</italic>
</source>
<volume>8</volume>
:<issue>13661</issue>
. <pub-id pub-id-type="doi">10.1038/s41598-018-32097-8</pub-id>
<pub-id pub-id-type="pmid">30209357</pub-id>
</mixed-citation>
</ref>
<ref id="B127"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname>
<given-names>K.</given-names>
</name>
<name><surname>Penttinen</surname>
<given-names>P.</given-names>
</name>
<name><surname>Guan</surname>
<given-names>T.</given-names>
</name>
<name><surname>Xiao</surname>
<given-names>J.</given-names>
</name>
<name><surname>Chen</surname>
<given-names>Q.</given-names>
</name>
<name><surname>Xu</surname>
<given-names>J.</given-names>
</name>
<etal></etal>
</person-group>
(<year>2011</year>
). <article-title>The diversity and anti-microbial activity of endophytic actinomycetes isolated from medicinal plants in Panxi Plateau.</article-title>
<source><italic>Chin. Curr. Microbiol.</italic>
</source>
<volume>62</volume>
<fpage>182</fpage>
–<lpage>190</lpage>
. <pub-id pub-id-type="doi">10.1007/s00284-010-9685-3</pub-id>
<pub-id pub-id-type="pmid">20567975</pub-id>
</mixed-citation>
</ref>
<ref id="B128"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname>
<given-names>P. J.</given-names>
</name>
<name><surname>Fan</surname>
<given-names>L. M.</given-names>
</name>
<name><surname>Li</surname>
<given-names>G. H.</given-names>
</name>
<name><surname>Zhu</surname>
<given-names>N.</given-names>
</name>
<name><surname>Shen</surname>
<given-names>Y. M.</given-names>
</name>
</person-group>
(<year>2005</year>
). <article-title>Antibacterial and antitumor macrolides from Streptomyces sp. Is9131.</article-title>
<source><italic>Arch. Pharm. Res.</italic>
</source>
<volume>28</volume>
<fpage>1228</fpage>
–<lpage>1232</lpage>
. <pub-id pub-id-type="doi">10.1007/BF029782031</pub-id>
<pub-id pub-id-type="pmid">16350846</pub-id>
</mixed-citation>
</ref>
</ref-list>
</back>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000552 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000552 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:6449470 |texte= Bioactive Products From Plant-Endophytic Gram-Positive Bacteria }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:30984118" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |