Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis</title><author><name sortKey="Wu, Jun" sort="Wu, Jun" uniqKey="Wu J" first="Jun" last="Wu">Jun Wu</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Tian Ping" sort="Zhang, Tian Ping" uniqKey="Zhang T" first="Tian-Ping" last="Zhang">Tian-Ping Zhang</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Yu Lan" sort="Zhao, Yu Lan" uniqKey="Zhao Y" first="Yu-Lan" last="Zhao">Yu-Lan Zhao</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Li, Bao Zhu" sort="Li, Bao Zhu" uniqKey="Li B" first="Bao-Zhu" last="Li">Bao-Zhu Li</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Leng, Rui Xue" sort="Leng, Rui Xue" uniqKey="Leng R" first="Rui-Xue" last="Leng">Rui-Xue Leng</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Pan, Hai Feng" sort="Pan, Hai Feng" uniqKey="Pan H" first="Hai-Feng" last="Pan">Hai-Feng Pan</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Ye, Dong Qing" sort="Ye, Dong Qing" uniqKey="Ye D" first="Dong-Qing" last="Ye">Dong-Qing Ye</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31905737</idno><idno type="pmc">7022387</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022387</idno><idno type="RBID">PMC:7022387</idno><idno type="doi">10.3390/biom10010055</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000430</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis</title><author><name sortKey="Wu, Jun" sort="Wu, Jun" uniqKey="Wu J" first="Jun" last="Wu">Jun Wu</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Tian Ping" sort="Zhang, Tian Ping" uniqKey="Zhang T" first="Tian-Ping" last="Zhang">Tian-Ping Zhang</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Yu Lan" sort="Zhao, Yu Lan" uniqKey="Zhao Y" first="Yu-Lan" last="Zhao">Yu-Lan Zhao</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Li, Bao Zhu" sort="Li, Bao Zhu" uniqKey="Li B" first="Bao-Zhu" last="Li">Bao-Zhu Li</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Leng, Rui Xue" sort="Leng, Rui Xue" uniqKey="Leng R" first="Rui-Xue" last="Leng">Rui-Xue Leng</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Pan, Hai Feng" sort="Pan, Hai Feng" uniqKey="Pan H" first="Hai-Feng" last="Pan">Hai-Feng Pan</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author><author><name sortKey="Ye, Dong Qing" sort="Ye, Dong Qing" uniqKey="Ye D" first="Dong-Qing" last="Ye">Dong-Qing Ye</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff></affiliation></author></analytic><series><title level="j">Biomolecules</title><idno type="eISSN">2218-273X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Long noncoding RNAs (lncRNAs) widely participate in human diseases by regulating gene transcription, modulating protein function, or acting as ceRNAs. Yet, their roles in rheumatoid arthritis (RA) remain obscure. In this study, the expression of three lncRNAs (H19, GAS5, and linc0597) in peripheral blood mononuclear cells (PBMCs) were detected in 77 RA patients and 78 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The association of lncRNAs related gene polymorphisms with RA were evaluated in 828 RA patients and 780 controls using TaqMan single nucleotide polymorphism (SNP) genotyping assays. We observed that the expression levels of H19, GAS5 and linc0597 were down-regulated in PBMCs of RA patients, of which GAS5 level decreased in patients with hypocomplementemia, and negatively correlated with C-reactive protein (CRP) level in RA patients. Moreover, we highlighted two related potential functional SNPs, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. The precise roles of these lncRNAs in mechanism of RA remain to be further explored.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Scott, D L" uniqKey="Scott D">D.L. Scott</name></author><author><name sortKey="Wolfe, F" uniqKey="Wolfe F">F. Wolfe</name></author><author><name sortKey="Huizinga, T W" uniqKey="Huizinga T">T.W. Huizinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, T P" uniqKey="Zhang T">T.P. Zhang</name></author><author><name sortKey="Lv, T T" uniqKey="Lv T">T.T. Lv</name></author><author><name sortKey="Xu, S Z" uniqKey="Xu S">S.Z. Xu</name></author><author><name sortKey="Pan, H F" uniqKey="Pan H">H.F. Pan</name></author><author><name sortKey="Ye, D Q" uniqKey="Ye D">D.Q. Ye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prado, M G" uniqKey="Prado M">M.G. Prado</name></author><author><name sortKey="Iversen, M D" uniqKey="Iversen M">M.D. Iversen</name></author><author><name sortKey="Yu, Z" uniqKey="Yu Z">Z. Yu</name></author><author><name sortKey="Miller, K R" uniqKey="Miller K">K.R. Miller</name></author><author><name sortKey="Triedman, N A" uniqKey="Triedman N">N.A. Triedman</name></author><author><name sortKey="Kalia, S S" uniqKey="Kalia S">S.S. Kalia</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B. Lu</name></author><author><name sortKey="Green, R C" uniqKey="Green R">R.C. Green</name></author><author><name sortKey="Karlson, E W" uniqKey="Karlson E">E.W. Karlson</name></author><author><name sortKey="Sparks, J A" uniqKey="Sparks J">J.A. Sparks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kallberg, H" uniqKey="Kallberg H">H. Kallberg</name></author><author><name sortKey="Padyukov, L" uniqKey="Padyukov L">L. Padyukov</name></author><author><name sortKey="Plenge, R M" uniqKey="Plenge R">R.M. Plenge</name></author><author><name sortKey="Ronnelid, J" uniqKey="Ronnelid J">J. Ronnelid</name></author><author><name sortKey="Gregersen, P K" uniqKey="Gregersen P">P.K. Gregersen</name></author><author><name sortKey="Van Der Helm Van Mil, A H" uniqKey="Van Der Helm Van Mil A">A.H. van der Helm-van Mil</name></author><author><name sortKey="Toes, R E" uniqKey="Toes R">R.E. Toes</name></author><author><name sortKey="Huizinga, T W" uniqKey="Huizinga T">T.W. Huizinga</name></author><author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L. Klareskog</name></author><author><name sortKey="Alfredsson, L" uniqKey="Alfredsson L">L. Alfredsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindstrom, T M" uniqKey="Lindstrom T">T.M. Lindstrom</name></author><author><name sortKey="Robinson, W H" uniqKey="Robinson W">W.H. Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furst, D E" uniqKey="Furst D">D.E. Furst</name></author><author><name sortKey="Emery, P" uniqKey="Emery P">P. Emery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mousavi, M J" uniqKey="Mousavi M">M.J. Mousavi</name></author><author><name sortKey="Jamshidi, A" uniqKey="Jamshidi A">A. Jamshidi</name></author><author><name sortKey="Chopra, A" uniqKey="Chopra A">A. Chopra</name></author><author><name sortKey="Aslani, S" uniqKey="Aslani S">S. Aslani</name></author><author><name sortKey="Akhlaghi, M" uniqKey="Akhlaghi M">M. Akhlaghi</name></author><author><name sortKey="Mahmoudi, M" uniqKey="Mahmoudi M">M. Mahmoudi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consortium, E P" uniqKey="Consortium E">E.P. Consortium</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consortium, E P" uniqKey="Consortium E">E.P. Consortium</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, Q" uniqKey="Luo Q">Q. Luo</name></author><author><name sortKey="Xu, C" uniqKey="Xu C">C. Xu</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Zeng, L" uniqKey="Zeng L">L. Zeng</name></author><author><name sortKey="Ye, J" uniqKey="Ye J">J. Ye</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mercer, T R" uniqKey="Mercer T">T.R. Mercer</name></author><author><name sortKey="Mattick, J S" uniqKey="Mattick J">J.S. Mattick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceppi, M" uniqKey="Ceppi M">M. Ceppi</name></author><author><name sortKey="Pereira, P M" uniqKey="Pereira P">P.M. Pereira</name></author><author><name sortKey="Dunand Sauthier, I" uniqKey="Dunand Sauthier I">I. Dunand-Sauthier</name></author><author><name sortKey="Barras, E" uniqKey="Barras E">E. Barras</name></author><author><name sortKey="Reith, W" uniqKey="Reith W">W. Reith</name></author><author><name sortKey="Santos, M A" uniqKey="Santos M">M.A. Santos</name></author><author><name sortKey="Pierre, P" uniqKey="Pierre P">P. Pierre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filkova, M" uniqKey="Filkova M">M. Filková</name></author><author><name sortKey="Aradi, B" uniqKey="Aradi B">B. Aradi</name></author><author><name sortKey="Senolt, L" uniqKey="Senolt L">L. Senolt</name></author><author><name sortKey="Ospelt, C" uniqKey="Ospelt C">C. Ospelt</name></author><author><name sortKey="Vettori, S" uniqKey="Vettori S">S. Vettori</name></author><author><name sortKey="Mann, H" uniqKey="Mann H">H. Mann</name></author><author><name sortKey="Filer, A" uniqKey="Filer A">A. Filer</name></author><author><name sortKey="Raza, K" uniqKey="Raza K">K. Raza</name></author><author><name sortKey="Buckley, C D" uniqKey="Buckley C">C.D. Buckley</name></author><author><name sortKey="Snow, M" uniqKey="Snow M">M. Snow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamachi, Y" uniqKey="Nakamachi Y">Y. Nakamachi</name></author><author><name sortKey="Kawano, S" uniqKey="Kawano S">S. Kawano</name></author><author><name sortKey="Takenokuchi, M" uniqKey="Takenokuchi M">M. Takenokuchi</name></author><author><name sortKey="Nishimura, K" uniqKey="Nishimura K">K. Nishimura</name></author><author><name sortKey="Sakai, Y" uniqKey="Sakai Y">Y. Sakai</name></author><author><name sortKey="Chin, T" uniqKey="Chin T">T. Chin</name></author><author><name sortKey="Saura, R" uniqKey="Saura R">R. Saura</name></author><author><name sortKey="Kurosaka, M" uniqKey="Kurosaka M">M. Kurosaka</name></author><author><name sortKey="Kumagai, S" uniqKey="Kumagai S">S. Kumagai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, H" uniqKey="Ma H">H. Ma</name></author><author><name sortKey="Hao, Y" uniqKey="Hao Y">Y. Hao</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X. Dong</name></author><author><name sortKey="Gong, Q" uniqKey="Gong Q">Q. Gong</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Tian, W" uniqKey="Tian W">W. Tian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C. Wang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Zhang, G" uniqKey="Zhang G">G. Zhang</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name></author><author><name sortKey="Zheng, H" uniqKey="Zheng H">H. Zheng</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huarte, M" uniqKey="Huarte M">M. Huarte</name></author><author><name sortKey="Guttman, M" uniqKey="Guttman M">M. Guttman</name></author><author><name sortKey="Feldser, D" uniqKey="Feldser D">D. Feldser</name></author><author><name sortKey="Garber, M" uniqKey="Garber M">M. Garber</name></author><author><name sortKey="Koziol, M J" uniqKey="Koziol M">M.J. Koziol</name></author><author><name sortKey="Kenzelmann Broz, D" uniqKey="Kenzelmann Broz D">D. Kenzelmann-Broz</name></author><author><name sortKey="Khalil, A M" uniqKey="Khalil A">A.M. Khalil</name></author><author><name sortKey="Zuk, O" uniqKey="Zuk O">O. Zuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z. Zhu</name></author><author><name sortKey="Watabe, K" uniqKey="Watabe K">K. Watabe</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Bai, C" uniqKey="Bai C">C. Bai</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M. Xu</name></author><author><name sortKey="Wu, F" uniqKey="Wu F">F. Wu</name></author><author><name sortKey="Mo, Y Y" uniqKey="Mo Y">Y.Y. Mo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salmena, L" uniqKey="Salmena L">L. Salmena</name></author><author><name sortKey="Poliseno, L" uniqKey="Poliseno L">L. Poliseno</name></author><author><name sortKey="Tay, Y" uniqKey="Tay Y">Y. Tay</name></author><author><name sortKey="Kats, L" uniqKey="Kats L">L. Kats</name></author><author><name sortKey="Pandolfi, P P" uniqKey="Pandolfi P">P.P. Pandolfi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, R A" uniqKey="Gupta R">R.A. Gupta</name></author><author><name sortKey="Shah, N" uniqKey="Shah N">N. Shah</name></author><author><name sortKey="Wang, K C" uniqKey="Wang K">K.C. Wang</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name></author><author><name sortKey="Horlings, H M" uniqKey="Horlings H">H.M. Horlings</name></author><author><name sortKey="Wong, D J" uniqKey="Wong D">D.J. Wong</name></author><author><name sortKey="Tsai, M C" uniqKey="Tsai M">M.C. Tsai</name></author><author><name sortKey="Hung, T" uniqKey="Hung T">T. Hung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xing, D" uniqKey="Xing D">D. Xing</name></author><author><name sortKey="Liang, J Q" uniqKey="Liang J">J.Q. Liang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J. Lu</name></author><author><name sortKey="Jia, H B" uniqKey="Jia H">H.B. Jia</name></author><author><name sortKey="Xu, L Y" uniqKey="Xu L">L.Y. Xu</name></author><author><name sortKey="Ma, X L" uniqKey="Ma X">X.L. Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stuhlmuller, B" uniqKey="Stuhlmuller B">B. Stuhlmüller</name></author><author><name sortKey="Kunisch, E" uniqKey="Kunisch E">E. Kunisch</name></author><author><name sortKey="Franz, J" uniqKey="Franz J">J. Franz</name></author><author><name sortKey="Martinez Gamboa, L" uniqKey="Martinez Gamboa L">L. Martinez-Gamboa</name></author><author><name sortKey="Hernandez, M M" uniqKey="Hernandez M">M.M. Hernandez</name></author><author><name sortKey="Pruss, A" uniqKey="Pruss A">A. Pruss</name></author><author><name sortKey="Ulbrich, N" uniqKey="Ulbrich N">N. Ulbrich</name></author><author><name sortKey="Erdmann, V A" uniqKey="Erdmann V">V.A. Erdmann</name></author><author><name sortKey="Burmester, G R" uniqKey="Burmester G">G.R. Burmester</name></author><author><name sortKey="Kinne, R W" uniqKey="Kinne R">R.W. Kinne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J. Ma</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Wu, L" uniqKey="Wu L">L. Wu</name></author><author><name sortKey="Qu, B" uniqKey="Qu B">B. Qu</name></author><author><name sortKey="Xia, S" uniqKey="Xia S">S. Xia</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y. Tang</name></author><author><name sortKey="Shen, N" uniqKey="Shen N">N. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, C" uniqKey="Schneider C">C. Schneider</name></author><author><name sortKey="King, R M" uniqKey="King R">R.M. King</name></author><author><name sortKey="Philipson, L" uniqKey="Philipson L">L. Philipson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayama, T" uniqKey="Mayama T">T. Mayama</name></author><author><name sortKey="Marr, A K" uniqKey="Marr A">A.K. Marr</name></author><author><name sortKey="Kino, T" uniqKey="Kino T">T. Kino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moharamoghli, M" uniqKey="Moharamoghli M">M. Moharamoghli</name></author><author><name sortKey="Hassan Zadeh, V" uniqKey="Hassan Zadeh V">V. Hassan-Zadeh</name></author><author><name sortKey="Dolatshahi, E" uniqKey="Dolatshahi E">E. Dolatshahi</name></author><author><name sortKey="Alizadeh, Z" uniqKey="Alizadeh Z">Z. Alizadeh</name></author><author><name sortKey="Farazmand, A" uniqKey="Farazmand A">A. Farazmand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnett, F C" uniqKey="Arnett F">F.C. Arnett</name></author><author><name sortKey="Edworthy, S M" uniqKey="Edworthy S">S.M. Edworthy</name></author><author><name sortKey="Bloch, D A" uniqKey="Bloch D">D.A. Bloch</name></author><author><name sortKey="Mcshane, D J" uniqKey="Mcshane D">D.J. McShane</name></author><author><name sortKey="Fries, J F" uniqKey="Fries J">J.F. Fries</name></author><author><name sortKey="Cooper, N S" uniqKey="Cooper N">N.S. Cooper</name></author><author><name sortKey="Healey, L A" uniqKey="Healey L">L.A. Healey</name></author><author><name sortKey="Kaplan, S R" uniqKey="Kaplan S">S.R. Kaplan</name></author><author><name sortKey="Liang, M H" uniqKey="Liang M">M.H. Liang</name></author><author><name sortKey="Luthra, H S" uniqKey="Luthra H">H.S. Luthra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuriya, B" uniqKey="Kuriya B">B. Kuriya</name></author><author><name sortKey="Schieir, O" uniqKey="Schieir O">O. Schieir</name></author><author><name sortKey="Lin, D" uniqKey="Lin D">D. Lin</name></author><author><name sortKey="Xiong, J" uniqKey="Xiong J">J. Xiong</name></author><author><name sortKey="Pope, J" uniqKey="Pope J">J. Pope</name></author><author><name sortKey="Boire, G" uniqKey="Boire G">G. Boire</name></author><author><name sortKey="Haraoui, B" uniqKey="Haraoui B">B. Haraoui</name></author><author><name sortKey="Thorne, J C" uniqKey="Thorne J">J.C. Thorne</name></author><author><name sortKey="Tin, D" uniqKey="Tin D">D. Tin</name></author><author><name sortKey="Hitchon, C" uniqKey="Hitchon C">C. Hitchon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahu, A" uniqKey="Sahu A">A. Sahu</name></author><author><name sortKey="Singhal, U" uniqKey="Singhal U">U. Singhal</name></author><author><name sortKey="Chinnaiyan, A M" uniqKey="Chinnaiyan A">A.M. Chinnaiyan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steck, E" uniqKey="Steck E">E. Steck</name></author><author><name sortKey="Boeuf, S" uniqKey="Boeuf S">S. Boeuf</name></author><author><name sortKey="Gabler, J" uniqKey="Gabler J">J. Gabler</name></author><author><name sortKey="Werth, N" uniqKey="Werth N">N. Werth</name></author><author><name sortKey="Schnatzer, P" uniqKey="Schnatzer P">P. Schnatzer</name></author><author><name sortKey="Diederichs, S" uniqKey="Diederichs S">S. Diederichs</name></author><author><name sortKey="Richter, W" uniqKey="Richter W">W. Richter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, J" uniqKey="Song J">J. Song</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D. Kim</name></author><author><name sortKey="Han, J" uniqKey="Han J">J. Han</name></author><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Lee, M" uniqKey="Lee M">M. Lee</name></author><author><name sortKey="Jin, E J" uniqKey="Jin E">E.J. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kino, T" uniqKey="Kino T">T. Kino</name></author><author><name sortKey="Hurt, D E" uniqKey="Hurt D">D.E. Hurt</name></author><author><name sortKey="Ichijo, T" uniqKey="Ichijo T">T. Ichijo</name></author><author><name sortKey="Nader, N" uniqKey="Nader N">N. Nader</name></author><author><name sortKey="Chrousos, G P" uniqKey="Chrousos G">G.P. Chrousos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, G C" uniqKey="Wu G">G.C. Wu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Leng, R X" uniqKey="Leng R">R.X. Leng</name></author><author><name sortKey="Li, X P" uniqKey="Li X">X.P. Li</name></author><author><name sortKey="Li, X M" uniqKey="Li X">X.M. Li</name></author><author><name sortKey="Wang, D G" uniqKey="Wang D">D.G. Wang</name></author><author><name sortKey="Pan, H F" uniqKey="Pan H">H.F. Pan</name></author><author><name sortKey="Ye, D Q" uniqKey="Ye D">D.Q. Ye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sigdel, K R" uniqKey="Sigdel K">K.R. Sigdel</name></author><author><name sortKey="Cheng, A" uniqKey="Cheng A">A. Cheng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Duan, L" uniqKey="Duan L">L. Duan</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, K W" uniqKey="Kim K">K.W. Kim</name></author><author><name sortKey="Kim, B M" uniqKey="Kim B">B.M. Kim</name></author><author><name sortKey="Moon, H W" uniqKey="Moon H">H.W. Moon</name></author><author><name sortKey="Lee, S H" uniqKey="Lee S">S.H. Lee</name></author><author><name sortKey="Kim, H R" uniqKey="Kim H">H.R. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holers, V M" uniqKey="Holers V">V.M. Holers</name></author><author><name sortKey="Bana, N K" uniqKey="Bana N">N.K. Bana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choy, E H" uniqKey="Choy E">E.H. Choy</name></author><author><name sortKey="Isenberg, D A" uniqKey="Isenberg D">D.A. Isenberg</name></author><author><name sortKey="Garrood, T" uniqKey="Garrood T">T. Garrood</name></author><author><name sortKey="Farrow, S" uniqKey="Farrow S">S. Farrow</name></author><author><name sortKey="Ioannou, Y" uniqKey="Ioannou Y">Y. Ioannou</name></author><author><name sortKey="Bird, H" uniqKey="Bird H">H. Bird</name></author><author><name sortKey="Cheung, N" uniqKey="Cheung N">N. Cheung</name></author><author><name sortKey="Williams, B" uniqKey="Williams B">B. Williams</name></author><author><name sortKey="Hazleman, B" uniqKey="Hazleman B">B. Hazleman</name></author><author><name sortKey="Price, R" uniqKey="Price R">R. Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishimoto, N" uniqKey="Nishimoto N">N. Nishimoto</name></author><author><name sortKey="Yoshizaki, K" uniqKey="Yoshizaki K">K. Yoshizaki</name></author><author><name sortKey="Miyasaka, N" uniqKey="Miyasaka N">N. Miyasaka</name></author><author><name sortKey="Yamamoto, K" uniqKey="Yamamoto K">K. Yamamoto</name></author><author><name sortKey="Kawai, S" uniqKey="Kawai S">S. Kawai</name></author><author><name sortKey="Takeuchi, T" uniqKey="Takeuchi T">T. Takeuchi</name></author><author><name sortKey="Hashimoto, J" uniqKey="Hashimoto J">J. Hashimoto</name></author><author><name sortKey="Azuma, J" uniqKey="Azuma J">J. Azuma</name></author><author><name sortKey="Kishimoto, T" uniqKey="Kishimoto T">T. Kishimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Chao, T C" uniqKey="Chao T">T.C. Chao</name></author><author><name sortKey="Chang, K Y" uniqKey="Chang K">K.Y. Chang</name></author><author><name sortKey="Lin, N" uniqKey="Lin N">N. Lin</name></author><author><name sortKey="Patil, V S" uniqKey="Patil V">V.S. Patil</name></author><author><name sortKey="Shimizu, C" uniqKey="Shimizu C">C. Shimizu</name></author><author><name sortKey="Head, S R" uniqKey="Head S">S.R. Head</name></author><author><name sortKey="Burns, J C" uniqKey="Burns J">J.C. Burns</name></author><author><name sortKey="Rana, T M" uniqKey="Rana T">T.M. Rana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Ma, G" uniqKey="Ma G">G. Ma</name></author><author><name sortKey="Sun, S H" uniqKey="Sun S">S.H. Sun</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y. Xu</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Jin, Y" uniqKey="Jin Y">Y. Jin</name></author><author><name sortKey="An, L" uniqKey="An L">L. An</name></author><author><name sortKey="Wu, B" uniqKey="Wu B">B. Wu</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H. Zhou</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Huang, K" uniqKey="Huang K">K. Huang</name></author><author><name sortKey="Wen, F" uniqKey="Wen F">F. Wen</name></author><author><name sortKey="Cui, G" uniqKey="Cui G">G. Cui</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H. Guo</name></author><author><name sortKey="Zhao, S" uniqKey="Zhao S">S. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahdi Eftekharian, M" uniqKey="Mahdi Eftekharian M">M. Mahdi Eftekharian</name></author><author><name sortKey="Noroozi, R" uniqKey="Noroozi R">R. Noroozi</name></author><author><name sortKey="Komaki, A" uniqKey="Komaki A">A. Komaki</name></author><author><name sortKey="Mazdeh, M" uniqKey="Mazdeh M">M. Mazdeh</name></author><author><name sortKey="Taheri, M" uniqKey="Taheri M">M. Taheri</name></author><author><name sortKey="Ghafouri Fard, S" uniqKey="Ghafouri Fard S">S. Ghafouri-Fard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, D" uniqKey="Sun D">D. Sun</name></author><author><name sortKey="Yu, Z" uniqKey="Yu Z">Z. Yu</name></author><author><name sortKey="Fang, X" uniqKey="Fang X">X. Fang</name></author><author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name></author><author><name sortKey="Pu, Y" uniqKey="Pu Y">Y. Pu</name></author><author><name sortKey="Shao, Q" uniqKey="Shao Q">Q. Shao</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name></author><author><name sortKey="Huang, A" uniqKey="Huang A">A. Huang</name></author><author><name sortKey="Xiang, Z" uniqKey="Xiang Z">Z. Xiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, P" uniqKey="Gao P">P. Gao</name></author><author><name sortKey="Xia, J H" uniqKey="Xia J">J.H. Xia</name></author><author><name sortKey="Sipeky, C" uniqKey="Sipeky C">C. Sipeky</name></author><author><name sortKey="Dong, X M" uniqKey="Dong X">X.M. Dong</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P. Zhang</name></author><author><name sortKey="Cruz, S P" uniqKey="Cruz S">S.P. Cruz</name></author><author><name sortKey="Zhang, K" uniqKey="Zhang K">K. Zhang</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hua, J T" uniqKey="Hua J">J.T. Hua</name></author><author><name sortKey="Ahmed, M" uniqKey="Ahmed M">M. Ahmed</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H. Guo</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Soares, F" uniqKey="Soares F">F. Soares</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J. Lu</name></author><author><name sortKey="Zhou, S" uniqKey="Zhou S">S. Zhou</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, A F" uniqKey="Huang A">A.F. Huang</name></author><author><name sortKey="Su, L C" uniqKey="Su L">L.C. Su</name></author><author><name sortKey="Jia, H" uniqKey="Jia H">H. Jia</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Xu, W D" uniqKey="Xu W">W.D. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, J Z" uniqKey="Zhou J">J.Z. Zhou</name></author><author><name sortKey="Li, J J" uniqKey="Li J">J.J. Li</name></author><author><name sortKey="Hua, D J" uniqKey="Hua D">D.J. Hua</name></author><author><name sortKey="Huang, S C" uniqKey="Huang S">S.C. Huang</name></author><author><name sortKey="Sun, Q Q" uniqKey="Sun Q">Q.Q. Sun</name></author><author><name sortKey="Huang, H" uniqKey="Huang H">H. Huang</name></author><author><name sortKey="Xin, X F" uniqKey="Xin X">X.F. Xin</name></author><author><name sortKey="Cen, H" uniqKey="Cen H">H. Cen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, M C" uniqKey="Lu M">M.C. Lu</name></author><author><name sortKey="Yu, H C" uniqKey="Yu H">H.C. Yu</name></author><author><name sortKey="Yu, C L" uniqKey="Yu C">C.L. Yu</name></author><author><name sortKey="Huang, H B" uniqKey="Huang H">H.B. Huang</name></author><author><name sortKey="Koo, M" uniqKey="Koo M">M. Koo</name></author><author><name sortKey="Tung, C H" uniqKey="Tung C">C.H. Tung</name></author><author><name sortKey="Lai, N S" uniqKey="Lai N">N.S. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, S" uniqKey="Ye S">S. Ye</name></author><author><name sortKey="Patodi, N" uniqKey="Patodi N">N. Patodi</name></author><author><name sortKey="Walker Bone, K" uniqKey="Walker Bone K">K. Walker-Bone</name></author><author><name sortKey="Reading, I" uniqKey="Reading I">I. Reading</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C. Cooper</name></author><author><name sortKey="Dennison, E" uniqKey="Dennison E">E. Dennison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spurlock, C F" uniqKey="Spurlock C">C.F. Spurlock</name></author><author><name sortKey="Tossberg, J T" uniqKey="Tossberg J">J.T. Tossberg</name></author><author><name sortKey="Matlock, B K" uniqKey="Matlock B">B.K. Matlock</name></author><author><name sortKey="Olsen, N J" uniqKey="Olsen N">N.J. Olsen</name></author><author><name sortKey="Aune, T M" uniqKey="Aune T">T.M. Aune</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messemaker, T C" uniqKey="Messemaker T">T.C. Messemaker</name></author><author><name sortKey="Frank Bertoncelj, M" uniqKey="Frank Bertoncelj M">M. Frank-Bertoncelj</name></author><author><name sortKey="Marques, R B" uniqKey="Marques R">R.B. Marques</name></author><author><name sortKey="Adriaans, A" uniqKey="Adriaans A">A. Adriaans</name></author><author><name sortKey="Bakker, A M" uniqKey="Bakker A">A.M. Bakker</name></author><author><name sortKey="Daha, N" uniqKey="Daha N">N. Daha</name></author><author><name sortKey="Gay, S" uniqKey="Gay S">S. Gay</name></author><author><name sortKey="Huizinga, T W" uniqKey="Huizinga T">T.W. Huizinga</name></author><author><name sortKey="Toes, R E" uniqKey="Toes R">R.E. Toes</name></author><author><name sortKey="Mikkers, H M" uniqKey="Mikkers H">H.M. Mikkers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, N" uniqKey="Muller N">N. Müller</name></author><author><name sortKey="Doring, F" uniqKey="Doring F">F. Doring</name></author><author><name sortKey="Klapper, M" uniqKey="Klapper M">M. Klapper</name></author><author><name sortKey="Neumann, K" uniqKey="Neumann K">K. Neumann</name></author><author><name sortKey="Schulte, D M" uniqKey="Schulte D">D.M. Schulte</name></author><author><name sortKey="Turk, K" uniqKey="Turk K">K. Türk</name></author><author><name sortKey="Schroder, J O" uniqKey="Schroder J">J.O. Schröder</name></author><author><name sortKey="Zeuner, R A" uniqKey="Zeuner R">R.A. Zeuner</name></author><author><name sortKey="Freitag Wolf, S" uniqKey="Freitag Wolf S">S. Freitag-Wolf</name></author><author><name sortKey="Schreiber, S" uniqKey="Schreiber S">S. Schreiber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moran, V A" uniqKey="Moran V">V.A. Moran</name></author><author><name sortKey="Perera, R J" uniqKey="Perera R">R.J. Perera</name></author><author><name sortKey="Khalil, A M" uniqKey="Khalil A">A.M. Khalil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khorkova, O" uniqKey="Khorkova O">O. Khorkova</name></author><author><name sortKey="Hsiao, J" uniqKey="Hsiao J">J. Hsiao</name></author><author><name sortKey="Wahlestedt, C" uniqKey="Wahlestedt C">C. Wahlestedt</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomolecules</journal-id><journal-id journal-id-type="iso-abbrev">Biomolecules</journal-id><journal-id journal-id-type="publisher-id">biomolecules</journal-id><journal-title-group><journal-title>Biomolecules</journal-title></journal-title-group><issn pub-type="epub">2218-273X</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31905737</article-id><article-id pub-id-type="pmc">7022387</article-id><article-id pub-id-type="doi">10.3390/biom10010055</article-id><article-id pub-id-type="publisher-id">biomolecules-10-00055</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Tian-Ping</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Yu-Lan</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Bao-Zhu</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-2453-5865</contrib-id><name><surname>Leng</surname><given-names>Rui-Xue</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Hai-Feng</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref><xref rid="c1-biomolecules-10-00055" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Ye</surname><given-names>Dong-Qing</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref><xref rid="c1-biomolecules-10-00055" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-biomolecules-10-00055"><label>1</label>Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</aff><aff id="af2-biomolecules-10-00055"><label>2</label>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</aff><author-notes><corresp id="c1-biomolecules-10-00055"><label>*</label>Correspondence: <email>panhaifeng@ahmu.edu.cn</email> (H.-F.P.); <email>anhuiydq@126.com</email> (D.-Q.Y.); Tel.: +86-551-65161165 (H.-F.P.); +86-551-65167726 (D.-Q.Y.); Fax: +86-551-65161171 (H.-F.P.); +86-551-65167726 (D.-Q.Y.)</corresp></author-notes><pub-date pub-type="epub"><day>29</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="collection"><month>1</month><year>2020</year></pub-date><volume>10</volume><issue>1</issue><elocation-id>55</elocation-id><history><date date-type="received"><day>15</day><month>10</month><year>2019</year></date><date date-type="accepted"><day>26</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 by the authors.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Long noncoding RNAs (lncRNAs) widely participate in human diseases by regulating gene transcription, modulating protein function, or acting as ceRNAs. Yet, their roles in rheumatoid arthritis (RA) remain obscure. In this study, the expression of three lncRNAs (H19, GAS5, and linc0597) in peripheral blood mononuclear cells (PBMCs) were detected in 77 RA patients and 78 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The association of lncRNAs related gene polymorphisms with RA were evaluated in 828 RA patients and 780 controls using TaqMan single nucleotide polymorphism (SNP) genotyping assays. We observed that the expression levels of H19, GAS5 and linc0597 were down-regulated in PBMCs of RA patients, of which GAS5 level decreased in patients with hypocomplementemia, and negatively correlated with C-reactive protein (CRP) level in RA patients. Moreover, we highlighted two related potential functional SNPs, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. The precise roles of these lncRNAs in mechanism of RA remain to be further explored.</p></abstract><kwd-group><kwd>Rheumatoid arthritis</kwd><kwd>Long noncoding RNAs</kwd><kwd>Single nucleotide polymorphisms</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-biomolecules-10-00055"><title>1. Introduction</title><p>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by autoantibodies, systemic inflammation, persistent synovitis, and irreversible joint cartilage and bone destruction [<xref rid="B1-biomolecules-10-00055" ref-type="bibr">1</xref>]. Some extra-articular symptoms, such as pleuritis and rheumatoid vasculitis, can cause complications and poor prognosis of RA [<xref rid="B1-biomolecules-10-00055" ref-type="bibr">1</xref>]. To date, RA affects approximately 1% of the global population [<xref rid="B2-biomolecules-10-00055" ref-type="bibr">2</xref>]. However, the certain aetiology and the exact pathogenesis of RA remains obscure. Recently, clinical trials and epidemiological data have indicated that the interaction of environmental factors, genetic factors, autoimmunity, endocrine system, and infection contributes to the initiation and progression of RA [<xref rid="B1-biomolecules-10-00055" ref-type="bibr">1</xref>,<xref rid="B3-biomolecules-10-00055" ref-type="bibr">3</xref>,<xref rid="B4-biomolecules-10-00055" ref-type="bibr">4</xref>]. Among them, the dysregulation of innate and adaptive immune response, including aberrant production of immune cells and imbalance of cytokines, were widely demonstrated to participate in RA [<xref rid="B5-biomolecules-10-00055" ref-type="bibr">5</xref>,<xref rid="B6-biomolecules-10-00055" ref-type="bibr">6</xref>]. Abundant genetic variants were broadly confirmed to play major roles in RA [<xref rid="B1-biomolecules-10-00055" ref-type="bibr">1</xref>]. Recently, emerging evidence has revealed that a subset of noncoding RNAs (ncRNAs) also play pivotal roles in RA [<xref rid="B7-biomolecules-10-00055" ref-type="bibr">7</xref>].</p><p>It has been shown that merely 1–2% of human genome encode amino acids and 80% of phenotype-related loci map to noncoding regions across the human genome [<xref rid="B8-biomolecules-10-00055" ref-type="bibr">8</xref>,<xref rid="B9-biomolecules-10-00055" ref-type="bibr">9</xref>]. NcRNAs take up a significant portion of non-coding regions [<xref rid="B10-biomolecules-10-00055" ref-type="bibr">10</xref>]. Currently, the majority of research attention in thousands of ncRNAs coded by mammalian genome has shown that ncRNAs may play pivotal roles in diverse biological functions of RA [<xref rid="B7-biomolecules-10-00055" ref-type="bibr">7</xref>,<xref rid="B11-biomolecules-10-00055" ref-type="bibr">11</xref>]. For instance, miRNAs may promote numerous immune processes, and their dysregulation and implications in RA are well accepted [<xref rid="B7-biomolecules-10-00055" ref-type="bibr">7</xref>], such as miR-155 targeting TAB2 to activation of inflammatory responses [<xref rid="B12-biomolecules-10-00055" ref-type="bibr">12</xref>], miR-16 targeting 3′-untranslated region (UTR) of TNF-α to be a signature of disease activity [<xref rid="B13-biomolecules-10-00055" ref-type="bibr">13</xref>], miR-124a acting as a disease biomarker and a potential target for treatment [<xref rid="B14-biomolecules-10-00055" ref-type="bibr">14</xref>], etc. Importantly, research on another type of ncRNAs named lncRNAs in RA is on the rise. LncRNAs, which were initially considered to be a kind of nonfunctional RNAs, were actually capable of manipulating gene expression, such as gene transcription, RNA splicing, chromosome remodeling and protein transport [<xref rid="B11-biomolecules-10-00055" ref-type="bibr">11</xref>,<xref rid="B15-biomolecules-10-00055" ref-type="bibr">15</xref>]. Besides, lncRNAs have the ability to associate with RNA molecules to regulate their translation such as mRNA, miRNA, and interact with proteins to modulate their functions [<xref rid="B16-biomolecules-10-00055" ref-type="bibr">16</xref>]. For instance, linc-p21 was activated by P53 for cell apoptosis by binding to ribonucleoprotein-K [<xref rid="B17-biomolecules-10-00055" ref-type="bibr">17</xref>]. miR-21 and GAS5 may inhibit each other’s expression due to negative correlation between the two lncRNAs [<xref rid="B18-biomolecules-10-00055" ref-type="bibr">18</xref>]. Moreover, lncRNAs as important ceRNAs to impact the distribution of miRNAs on their targets also have received extensive attention [<xref rid="B19-biomolecules-10-00055" ref-type="bibr">19</xref>].</p><p>Increasing evidence has supported significant regulatory roles of lncRNAs in inflammatory responses, such as regulating the differentiation and activation of immune cells [<xref rid="B15-biomolecules-10-00055" ref-type="bibr">15</xref>]. In this term, several lncRNAs exhibited aberrant expression profiles in inflamed joint tissues of RA. Hotair is one of the earliest identified lncRNAs with abnormal expression in RA patients, it may interact with polycomb repressive complex 2 to regulate chromatin status [<xref rid="B20-biomolecules-10-00055" ref-type="bibr">20</xref>]. Compared with normal tissues, Hotair overexpressed in RA cartilages [<xref rid="B21-biomolecules-10-00055" ref-type="bibr">21</xref>]. Stuhlmüller et al. found that H19 expression was up-regulated in RA synovial tissue and might be induced by cytokines in synovial fibroblasts [<xref rid="B22-biomolecules-10-00055" ref-type="bibr">22</xref>]. Wu et al. showed that linc0597 (BZRAP1-AS1) decreased in peripheral blood mononuclear cells (PBMCs) of patients with RA [<xref rid="B23-biomolecules-10-00055" ref-type="bibr">23</xref>]. GAS5 originally discovered as a highly expressed ncRNA in growth-retarded cells was another aberrantly expressed lncRNA in RA [<xref rid="B24-biomolecules-10-00055" ref-type="bibr">24</xref>]. Mayama et al. demonstrated that GAS5 expression decreased in B cells and CD4 + T-cells of RA patients [<xref rid="B25-biomolecules-10-00055" ref-type="bibr">25</xref>]. Conversely, Moharamoghli et al. reported that GAS5 expression was up-regulated in T-cells of RA patients [<xref rid="B26-biomolecules-10-00055" ref-type="bibr">26</xref>]. Thus, compelling evidence showing the relevance of lncRNAs with RA is emerging, and in-depth research on the role of lncRNAs in RA is an urgent issue.</p><p>To further explore the implications of lncRNAs in RA, this study based on the available evidence hypothesized that H19, linc0597 and GAS5 may be involved in the pathogenesis of RA. A two-stage study of lncRNAs in RA was established. We aimed to investigate the three lncRNAs expression levels in PBMCs of RA patients, as well as explore the associations of lncRNAs expression and their gene single nucleotide polymorphisms (SNPs) with RA susceptibility.</p></sec><sec id="sec2-biomolecules-10-00055"><title>2. Materials and Methods</title><sec id="sec2dot1-biomolecules-10-00055"><title>2.1. Patients and Controls</title><p>During the years 2016–2017, 77 RA patients and 78 controls were enrolled to investigate the expression of H19, GAS5 and linc0597 in PBMCs, 828 RA patients and 780 controls were recruited to explore the association of gene polymorphisms with disease susceptibility. RA patients diagnosed according to 1987 revised American College of Rheumatology (ACR) diagnostic criteria [<xref rid="B27-biomolecules-10-00055" ref-type="bibr">27</xref>] were recruited from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University. Controls were selected from health blood donors, the physical examination center of the First Affiliated Hospital of Anhui Medical University, and the Second Affiliated Hospital of Anhui Medical University. RA disease severity was evaluated with DAS28-ESR [<xref rid="B28-biomolecules-10-00055" ref-type="bibr">28</xref>], available at <uri xlink:href="http://www.das-score.nl">http://www.das-score.nl</uri>. Exclusion criteria of patients were as follows: (1) Patients suspected of alcohol or drug abuse; (2) Patients complicated with other autoimmune diseases, cancers, systemic infectious diseases, severe heart liver and renal failure; (3) Patients with serious acute infections within one month before admission. Inclusion criteria of controls were as follows: (1) The general Han population; (2) With no history of autoimmune diseases or chronic diseases, including their families; (3) Without any other inflammatory rheumatologic conditions or major diseases; (4) Have not taken hormones or immunosuppressant drugs within one month before admission. Demographic, disease activity and laboratory parameter were collected from questionnaires and medical records. Study was approved by the Medical Ethics Committee of Anhui Medical University (Anhui Medical University 20180078), was conducted according to Declaration of Helsinki principles, and informed consent was obtained from each subject.</p></sec><sec id="sec2dot2-biomolecules-10-00055"><title>2.2. Quantitative Real-Time Reverse Transcription Polymerase Chain Reaction</title><p>After obtaining informed consent, we collected 5 mL EDTA-anticoagulated blood sample from study subject. PBMCs were freshly isolated from peripheral blood within 4 h and stored at −80 °C. Total RNAs were extracted from PBMCs using TRIzol reagent. In addition, the concentrations and purity of these total RNA samples were measured by NanoDrop™2000 spectrophotometer (Thermo Scientific, Waltham, MA, USA). All of the qualified total RNAs were reverse-transcribed into cDNA based on instructions of the Prime Script TM RT reagent Kit (Takara Bio Inc, Shiga Prefecture, Japan), and stored at −80 °C for further detection.</p><p>The qRT-PCR was carried out in duplicate in an optical 96-well plate with a MyCyclerTM Thermal Cycler system by using ABI ViiA™ 7 Real-Time PCR System (Applied Biosystems, Foster City, CA, USA). The qRT-PCR primer sequences are listed in <xref rid="biomolecules-10-00055-t001" ref-type="table">Table 1</xref>. Housekeeping gene β-actin was used as internal control. According to specifications of SYBR Green (SYBR<sup>®</sup> Premix Ex Taq™ II, Takara Bio Inc, Shiga Prefecture, Japan), 0.4 μL forward primer and 0.4 μL reverse primer (10 μM) were applied into qRT-PCR reaction system. Thermal cycling conditions were as follows: 95 °C for 1 min, followed by 42 cycles at 95 °C for 10 s, 60 °C for 30 s and 72 °C for 1 min. 2−∆∆Ct method normalized to endogenous control was used for calculating the relative expression levels of lncRNAs.</p></sec><sec id="sec2dot3-biomolecules-10-00055"><title>2.3. Genotyping</title><p>The selection of SNPs was based on the available references, and in combine with expression Quantitative Trait Locus (e-QTLs) data of the three lncRNAs from the Genotype Tissue Expression (GTEx) database (<uri xlink:href="https://gtexportal.org/home/">https://gtexportal.org/home/</uri>). Then, location of genetic information for selected SNPs was verified by data bases of National Center for Biotechnology Information (NCBI) and Ensemble. The minor allele frequencies of all SNPs must be more than 0.05 in a Chinese Han population. In addition, we preferred to select SNPs located in their flanking 2000 bp regions, as well as located in important functional positions, such as 3′UTR, 5′UTR, nonsynonymous mutations. and frameshift mutations. Finally, fourteen SNPs (rs2067051 and rs2075745 for H19; rs6790, rs16847206, and rs6692753 for GAS5; rs2070107, rs2877877, rs2632516, rs2285991, rs8071916, rs12601867, rs13414, rs2680700, and rs4372750 for linc0597) were enrolled into the analysis.</p><p>According to the instructions of the Flexi Gene-DNA Kit (Qiagen, Valencia, CA, USA), genomic DNAs were extracted from peripheral blood leukocytes. All SNPs were genotyped by an EP1 platform (Fluidigm, South San Francisco, CA, USA) using TaqMan SNP genotyping assays in accordance with manufacturer’s instructions.</p></sec><sec id="sec2dot4-biomolecules-10-00055"><title>2.4. Statistical Analysis</title><p>Data were visualized and analyzed with SPSS 23.0 and GraphPad Prism 5.0 (GraphPad Software, La Jolla, CA, USA). Data based on their types were expressed as frequency, percentage, mean ± standard deviation (SD) or median (interquartile range, IQR) respectively. The differences of each lncRNA expression within two groups were analyzed by nonparametric Mann-Whitney U test. Correlation analysis employed the Spearman’s rank correlation coefficient test. The distribution of genotypic and allelic frequencies within each group was evaluated with chi-square test (<italic>χ</italic><sup>2</sup>) or fisher’s exact test, odds ratio (OR) and 95% confidence interval (CI) were determined by logistic regression analysis. Besides, dominant model and recessive model were included in the analysis. A two-tailed <italic>p</italic> value ≤ 0.05 was considered statistically significant.</p></sec></sec><sec sec-type="results" id="sec3-biomolecules-10-00055"><title>3. Results</title><p>This two-stage case-control study was conducted in a Han Chinese population. Seventy-seven RA patients and 78 controls were recruited to investigate expression of H19, GAS5 and linc0597 in PBMCs in stage one. Eight-hundred twenty-eight RA patients and 780 controls were enrolled to detect gene polymorphisms of differentially expressed lncRNAs in stage two. There were no differences in gender and age distribution between patients and controls at both two stages (all <italic>p</italic> > 0.05). All SNPs genotyped successfully were in accordance with Hardy-Weinberg equilibrium (all <italic>p</italic> >0.05) (<xref ref-type="app" rid="app1-biomolecules-10-00055">Tables S1 and S2</xref>).</p><sec id="sec3dot1-biomolecules-10-00055"><title>3.1. LncRNAs Expression in PBMCs of Patients with RA.</title><p>The expression levels of selected lncRNAs (H19, GAS5 and linc0597) were significantly decreased in PBMCs from RA patients compared with controls (GAS5, <italic>Z</italic> = −4.821, <italic>p</italic> < 0.001; linc0597, <italic>Z</italic> = −6.095, <italic>p</italic> < 0.001; H19, <italic>Z</italic> = −2.330, <italic>p</italic> = 0.020) (<xref ref-type="fig" rid="biomolecules-10-00055-f001">Figure 1</xref>).</p><p>The correlations between H19, GAS5 and linc0597 levels and major laboratory parameters or disease activity of RA patients were further analyzed (<xref rid="biomolecules-10-00055-t002" ref-type="table">Table 2</xref> and <xref rid="biomolecules-10-00055-t003" ref-type="table">Table 3</xref>). GAS5 level was down-regulated in RA patients with hypocomplementemia than those with normal levels of complements (<italic>Z</italic> = −2.259, <italic>p</italic> = 0.024). Correlation analysis demonstrated that GAS5 level was negatively associated with C-reactive protein (CRP) level (<italic>r<sub>s</sub></italic>= −0.273, <italic>p</italic> = 0.017). We found no associations of H19 and linc0597 levels with laboratory parameters (all <italic>p</italic> > 0.05). Likewise, these three lncRNAs were not correlated with disease activity of RA patients (all <italic>p</italic> > 0.05).</p><p>When the potential effects of medical therapies on lncRNAs expression were considered, we observed that none of RA patients treated for immunosuppressive therapy. Expression of H19, GAS5 and linc0597 exhibited no statistical differences between RA patients who treated with medium to high doses of prednisone (>7.5 mg/day) and those who treated with low doses of prednisone (≤7.5 mg/day) (all <italic>p</italic> > 0.05). Compared with RA patients treated with any of the following disease modifying antirheumatic drugs (DMARDS): hydroxychloroquine, methotrexate, leflunomide or sulfasalazine, expression of the three lncRNAs showed no differences in RA patients who have not received treatment with DMARDS either (all <italic>p</italic> > 0.05). Similarly, the three lncRNAs showed no differences between RA patients who have received botanical preparation treatment or not, such as total glucosides of paeony (all <italic>p</italic> > 0.05) (<xref rid="biomolecules-10-00055-t004" ref-type="table">Table 4</xref>).</p></sec><sec id="sec3dot2-biomolecules-10-00055"><title>3.2. Association between lncRNAs Gene Single Nucleotide Polymorphisms and RA Susceptibility</title><p>Fourteen SNPs (rs2067051 and rs2075745 for H19; rs6790, rs16847206, and rs6692753 for GAS5; rs2070107, rs2877877, rs2632516, rs2285991, rs8071916, rs12601867, rs13414, rs2680700, and rs4372750 for linc0597) were selected to detect the correlation of lncRNAs related gene polymorphisms with RA susceptibility in 828 RA patients and 780 controls. Our results demonstrated that the genotype frequencies of rs6790 and rs2680700 were associated with RA risk (all <italic>p</italic> < 0.05) (<xref rid="biomolecules-10-00055-t005" ref-type="table">Table 5</xref>). However, we failed to observe the associations of lncRNAs gene variation with RA risk under dominant models and recessive models (all <italic>p</italic> > 0.05).</p><p>We further analyzed the correlations of lncRNAs SNPs with major clinical features in RA patients (<xref ref-type="app" rid="app1-biomolecules-10-00055">Table S3</xref>). There were associations between rs2285991 and anti-cyclic citrullinated peptide (anti -CCP) and rheumatoid factor (RF) (all <italic>p</italic> < 0.05).</p></sec><sec id="sec3dot3-biomolecules-10-00055" sec-type="subjects"><title>3.3. Association of lncRNAs Expression Levels with Their Gene Single Nucleotide Polymorphisms in RA Patients</title><p>The associations between H19, GAS5 and linc0597 expression and genotypes in RA patients were analyzed, and the results showed that rs4372750 was correlated with GAS5 expression level (<xref rid="biomolecules-10-00055-t006" ref-type="table">Table 6</xref>).</p></sec></sec><sec sec-type="discussion" id="sec4-biomolecules-10-00055"><title>4. Discussion</title><p>RA is a complex autoimmune disease resulting from multiple factors, as well as a clinical syndrome spanning several disease subsets [<xref rid="B1-biomolecules-10-00055" ref-type="bibr">1</xref>]. To the best of our knowledge, almost all of RA disease subsets present persistent synovial inflammation, associated bone, and articular cartilage damage [<xref rid="B1-biomolecules-10-00055" ref-type="bibr">1</xref>]. These disorders complicated with extra-articular diseases can damage any part of the body [<xref rid="B3-biomolecules-10-00055" ref-type="bibr">3</xref>]. Recent research has advanced the understanding of RA pathogenesis to the point where lncRNAs biological functions for RA pathogenetic process are underway, and the excavation of novel functions of thousands of lncRNAs promoted us to explore their affects in RA.</p><p>In the present study, we investigated three lncRNAs (H19, GAS5 and linc0597) expression profiles in PBMCs of patients with RA by qT-PCR in the first stage, and further analyzed the correlations between their expression and laboratory parameters of RA patients. The results demonstrated that the expression levels of H19, GAS5 and linc0597 were lower in RA patients. H19 could exert carcinogenesis as precursor of miRNA or ceRNA, such as precursor for miR-675 and modulating let-7 family of miRNAs [<xref rid="B29-biomolecules-10-00055" ref-type="bibr">29</xref>]. Metabolic stress-induced H19 and its encoded miR-675 could regulate inflammatory and hypoxic conditions by directly affecting COL2A1 [<xref rid="B30-biomolecules-10-00055" ref-type="bibr">30</xref>]. The expression of H19 in RA synovial fibroblasts was not only induced by cytokines/serum starvation but also correlated with mRNA expression for TIMP-2 [<xref rid="B22-biomolecules-10-00055" ref-type="bibr">22</xref>]. Taken together, it is fully suggested that H19 may play a pathogenic role in RA. However, Stuhlmüller et al. reported that H19 was overexpressed in RA synovial tissues [<xref rid="B22-biomolecules-10-00055" ref-type="bibr">22</xref>]. Song et al. indicated that H19 antisense expression was higher in PBMCs of patients with RA [<xref rid="B31-biomolecules-10-00055" ref-type="bibr">31</xref>]. However, our study showed that the expression level of H19 decreased in PBMCs of patients with RA. The possible explanation is that different locations in the genome of this lncRNA or lncRNAs expression possess tissue specificity. In addition, we also studied GAS5 in patients with RA. Indeed, related research on several other autoimmune diseases has shown its vital roles in a wide range of biological processes. GAS5 was reported to bind glucocorticoid receptor (GR) DNA-binding domain (DBD) and suppress GR-induced transcriptional activity, thereby inducing apoptosis [<xref rid="B32-biomolecules-10-00055" ref-type="bibr">32</xref>]. Most importantly, GAS5 was demonstrated to promote apoptosis and trigger growth arrest in human T-cells [<xref rid="B33-biomolecules-10-00055" ref-type="bibr">33</xref>]. All of the above are implicated in the pathogenesis of RA [<xref rid="B34-biomolecules-10-00055" ref-type="bibr">34</xref>]. Moreover, negative correlations between GAS5 expression and CRP level and hypocomplementemia in patients with RA were also found in our study. CRP is a product of inflammatory response, playing pro-inflammatory roles in RA by activating complements and inducing osteoclast differentiation, and acts as an indicator of treatment efficacy [<xref rid="B35-biomolecules-10-00055" ref-type="bibr">35</xref>]. Besides, complement system plays central roles in numerous protective immune processes [<xref rid="B36-biomolecules-10-00055" ref-type="bibr">36</xref>]. Complement C3 and C4 are also one of the most important indicators of RA disease activity [<xref rid="B36-biomolecules-10-00055" ref-type="bibr">36</xref>]. Thus, we speculate that GAS5 may play a pivotal role in the pathogenesis of RA, and its underlying mechanism is worth further exploration. Furthermore, it is generally acknowledged that TNF-α and IL-6 are documented in RA pathogenesis [<xref rid="B37-biomolecules-10-00055" ref-type="bibr">37</xref>,<xref rid="B38-biomolecules-10-00055" ref-type="bibr">38</xref>]. Linc0597 expression level was lower in THP1 macrophages and might regulate the induction of pro-inflammatory TNF-α and IL-6 [<xref rid="B39-biomolecules-10-00055" ref-type="bibr">39</xref>]. However, linc0597, which was previously found to be highly expressed in PBMCs of patients with RA [<xref rid="B23-biomolecules-10-00055" ref-type="bibr">23</xref>], showed low expression level in our study. One explanation is that a different internal control was used between two studies. The other explanation is that linc0597 expression may be affected by clinical treatment.</p><p>Then, gene polymorphisms of differentially expressed lncRNAs (rs2067051 and rs2075745 for H19; rs6790, rs16847206, and rs6692753 for GAS5; rs2070107, rs2877877, rs2632516, rs2285991, rs8071916, rs12601867, rs13414, rs2680700, and rs4372750 for linc0597) with RA susceptibility were detected in the second stage. Among these fourteen SNPs, rs12601867, rs13414, rs2680700, rs4372750, rs16847206, rs8071916, and rs6692753 were first reported in this study, and rs6790 genotype (GA) and rs2680700 genotype (GT) were found to be associated with RA risk. Previous studies prompted that certain functional SNPs within the promoter region of GAS5 could regulation its expression, and were related to risk of cancers, among which rs6790 were suggested as a biomarker for chemoradiotherapy induced toxic reactions in nasopharyngeal cancer patients [<xref rid="B40-biomolecules-10-00055" ref-type="bibr">40</xref>,<xref rid="B41-biomolecules-10-00055" ref-type="bibr">41</xref>,<xref rid="B42-biomolecules-10-00055" ref-type="bibr">42</xref>]. CHIP-seq data showed that rs6790 was labeled as an active promoter region or enhancer region position, and silico analysis suggested that this SNP also possessed a significant feature of e-QTL, both of them verified its contribution in the genetic variance of GAS5 expression [<xref rid="B41-biomolecules-10-00055" ref-type="bibr">41</xref>]. Similarly, rs6790 was reported to play inhibitory functions of GAS5 on the transcriptional activity of GR in autoimmune disease [<xref rid="B43-biomolecules-10-00055" ref-type="bibr">43</xref>], GAS5 knock-down could attenuate the progression of experimental autoimmune encephalomyelitis (EAE) and promote remyelination [<xref rid="B44-biomolecules-10-00055" ref-type="bibr">44</xref>]. Since no studies reported on linc0597 rs2680700, we tried to explore its potential functions through bioinformatics databases. rs2680700 is also labeled as an enhancer region according to ChIP-seq data, and it has a strong feature of e-QTL in several tissues (<xref ref-type="app" rid="app1-biomolecules-10-00055">Table S4</xref>), suggesting that rs2680700 might exert their roles through affecting the expression of target genes. Taken together, these data provide evidence for functional contribution of rs2680700 in changing linc0597 expression or stability. However, the exact roles of these two SNPs in RA still need further exploration [<xref rid="B45-biomolecules-10-00055" ref-type="bibr">45</xref>,<xref rid="B46-biomolecules-10-00055" ref-type="bibr">46</xref>]. Additionally, we attempted to discover the correlations of H19 expression with their gene polymorphisms in RA patients, but still no statistically significant results were found. Similarly, Huang et al. and Zhou et al. showed that H19 (rs2839698, rs3741219 and rs217727) gene polymorphisms were not related to RA risk in a Chinese population [<xref rid="B47-biomolecules-10-00055" ref-type="bibr">47</xref>,<xref rid="B48-biomolecules-10-00055" ref-type="bibr">48</xref>], indicating that there might be other mechanisms for H19 in RA pathogenesis.</p><p>Presently, more and more studies reveal the impact of lncRNAs on the pathogenesis of RA. There are evidence that lncRNAs regulate sphingomyelin phosphodiesterase 1 (SMPD1), and SMPD1 can regulate differentiation and apoptosis in T-cells [<xref rid="B49-biomolecules-10-00055" ref-type="bibr">49</xref>]. Additionally, Hotair contributes to RA pathogenesis through activation of matrix metalloproteinases 2 (MMP-2) and MMP-13 in synoviocytes and osteoclasts [<xref rid="B31-biomolecules-10-00055" ref-type="bibr">31</xref>], and MMPs play vital roles in recruitment of inflammatory cells and degradation of cartilage and bone of RA [<xref rid="B50-biomolecules-10-00055" ref-type="bibr">50</xref>]. Linc-p21 was confirmed to be negative regulators of NF-κB activity, and NF-κB is a pro-inflammatory transcription factor of RA patients [<xref rid="B51-biomolecules-10-00055" ref-type="bibr">51</xref>]. At present, emerging evidence proved that lncRNAs might regulate transcript levels of genes in the same genomic region, for instance, lncRNA C5T1 located in TRAF1-C5 influenced C5 mRNA level in RA risk [<xref rid="B52-biomolecules-10-00055" ref-type="bibr">52</xref>]. Last but not least, the regulation of lncRNAs might be specific in cells of innate immune system [<xref rid="B53-biomolecules-10-00055" ref-type="bibr">53</xref>]. For instance, Müller et al. reported that 7419 lncRNAs were detected in CD14+ monocytes isolated before and after IL-6 or TNF-α inhibition in RA, among them, only 85 lncRNAs examined exhibited up-regulation and down-regulation by anti-cytokine treatment initiated, and none of lncRNAs identified showed a similar pattern in response to IL-6 versus TNF-α inhibition [<xref rid="B53-biomolecules-10-00055" ref-type="bibr">53</xref>]. Overall, lncRNAs are emerging as key regulators of activation, differentiation, and expression of immune cells, which may direct or indirect link to cellular and tissue homeostasis of autoimmunity [<xref rid="B54-biomolecules-10-00055" ref-type="bibr">54</xref>,<xref rid="B55-biomolecules-10-00055" ref-type="bibr">55</xref>].</p><p>Several limitations should be acknowledged in our study. Due to the lack of data on non-steroidal anti-inflammatory drug (NSAIDs), the effects of NSAIDs on the expression of lncRNAs in RA patients might not be known. In addition, this is a hospital-based case-control study, so that a causal relationship was difficultly determined between RA risk and lncRNAs expression.</p></sec><sec sec-type="conclusions" id="sec5-biomolecules-10-00055"><title>5. Conclusions</title><p>Our study discovered down-regulated expression of H19, linc0597 and GAS5 in RA patients, GAS5 level is correlated with complement and CRP of RA patients. Moreover, we highlighted two related potential functional locus, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. Future studies are still needed to further explore the exact roles of these lncRNAs in the development and pathogenesis of RA.</p></sec></body><back><app-group><app id="app1-biomolecules-10-00055"><title>Supplementary Materials</title><p>The following are available online at <uri xlink:href="https://www.mdpi.com/2218-273X/10/1/55/s1">https://www.mdpi.com/2218-273X/10/1/55/s1</uri>, Table S1: Characteristics of RA patients and controls in the stage of lncRNAs expression detection, Table S2: Characteristics of RA patients and controls in the stage of genotyping, Table S3: Associations of fourteen SNPs with risk of different serotypes in RA patients, Table S4: e-QTLs effects of rs2680700 and rs6790 in multi-tissues.</p><supplementary-material content-type="local-data" id="biomolecules-10-00055-s001"><media xlink:href="biomolecules-10-00055-s001.pdf"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></app></app-group><notes><title>Author Contributions</title><p>Conceptualization, D.-Q.Y.; methodology, H.-F.P.; software, Y.-L.Z.; validation, J.W. and T.-P.Z.; formal analysis, J.W.; investigation, J.W. and Y.-L.Z.; resources, R.-X.L.; data curation, J.W.; writing-original draft preparation, J.W.; writing-review and editing, J.W. and D.-Q.Y.; visualization, B.-Z.L.; supervision, D.-Q.Y.; project administration, H.-F.P. and D.-Q.Y.; funding acquisition, D.-Q.Y. All authors have read and agreed to the published version of the manuscript.</p></notes><notes><title>Funding</title><p>This work was supported by grants from the National Natural Science Foundation of China, grant number 81872687 and 81872693.</p></notes><notes notes-type="COI-statement"><title>Conflicts of Interest</title><p>The authors declare no conflict of interest.</p></notes><ref-list><title>References</title><ref id="B1-biomolecules-10-00055"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scott</surname><given-names>D.L.</given-names></name><name><surname>Wolfe</surname><given-names>F.</given-names></name><name><surname>Huizinga</surname><given-names>T.W.</given-names></name></person-group><article-title>Rheumatoid arthritis</article-title><source>Lancet</source><year>2010</year><volume>376</volume><fpage>1094</fpage><lpage>1098</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(10)60826-4</pub-id><pub-id pub-id-type="pmid">20870100</pub-id></element-citation></ref><ref id="B2-biomolecules-10-00055"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>T.P.</given-names></name><name><surname>Lv</surname><given-names>T.T.</given-names></name><name><surname>Xu</surname><given-names>S.Z.</given-names></name><name><surname>Pan</surname><given-names>H.F.</given-names></name><name><surname>Ye</surname><given-names>D.Q.</given-names></name></person-group><article-title>Association of interleukin-10 gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population</article-title><source>Postgrad. Med. J.</source><year>2018</year><volume>94</volume><fpage>284</fpage><lpage>288</lpage><pub-id pub-id-type="doi">10.1136/postgradmedj-2017-135441</pub-id><pub-id pub-id-type="pmid">29487192</pub-id></element-citation></ref><ref id="B3-biomolecules-10-00055"><label>3.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prado</surname><given-names>M.G.</given-names></name><name><surname>Iversen</surname><given-names>M.D.</given-names></name><name><surname>Yu</surname><given-names>Z.</given-names></name><name><surname>Miller</surname><given-names>K.R.</given-names></name><name><surname>Triedman</surname><given-names>N.A.</given-names></name><name><surname>Kalia</surname><given-names>S.S.</given-names></name><name><surname>Lu</surname><given-names>B.</given-names></name><name><surname>Green</surname><given-names>R.C.</given-names></name><name><surname>Karlson</surname><given-names>E.W.</given-names></name><name><surname>Sparks</surname><given-names>J.A.</given-names></name></person-group><article-title>Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool With or Without a Health Educator for Knowledge of Rheumatoid Arthritis Risk Factors</article-title><source>Arthritis Care Res. (Hoboken)</source><year>2018</year><volume>70</volume><fpage>1421</fpage><lpage>1430</lpage><pub-id pub-id-type="doi">10.1002/acr.23510</pub-id><pub-id pub-id-type="pmid">29316383</pub-id></element-citation></ref><ref id="B4-biomolecules-10-00055"><label>4.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kallberg</surname><given-names>H.</given-names></name><name><surname>Padyukov</surname><given-names>L.</given-names></name><name><surname>Plenge</surname><given-names>R.M.</given-names></name><name><surname>Ronnelid</surname><given-names>J.</given-names></name><name><surname>Gregersen</surname><given-names>P.K.</given-names></name><name><surname>van der Helm-van Mil</surname><given-names>A.H.</given-names></name><name><surname>Toes</surname><given-names>R.E.</given-names></name><name><surname>Huizinga</surname><given-names>T.W.</given-names></name><name><surname>Klareskog</surname><given-names>L.</given-names></name><name><surname>Alfredsson</surname><given-names>L.</given-names></name><etal></etal></person-group><article-title>Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis</article-title><source>Am. J. Hum. Genet.</source><year>2007</year><volume>80</volume><fpage>867</fpage><lpage>875</lpage><pub-id pub-id-type="doi">10.1086/516736</pub-id><pub-id pub-id-type="pmid">17436241</pub-id></element-citation></ref><ref id="B5-biomolecules-10-00055"><label>5.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lindstrom</surname><given-names>T.M.</given-names></name><name><surname>Robinson</surname><given-names>W.H.</given-names></name></person-group><article-title>Rheumatoid arthritis: A role for immunosenescence?</article-title><source>J. Am. Geriatr. Soc.</source><year>2010</year><volume>58</volume><fpage>1565</fpage><lpage>1575</lpage><pub-id pub-id-type="doi">10.1111/j.1532-5415.2010.02965.x</pub-id><pub-id pub-id-type="pmid">20942872</pub-id></element-citation></ref><ref id="B6-biomolecules-10-00055"><label>6.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Furst</surname><given-names>D.E.</given-names></name><name><surname>Emery</surname><given-names>P.</given-names></name></person-group><article-title>Rheumatoid arthritis pathophysiology: Update on emerging cytokine and cytokine-associated cell targets</article-title><source>Rheumatology (Oxf.)</source><year>2014</year><volume>53</volume><fpage>1560</fpage><lpage>1569</lpage><pub-id pub-id-type="doi">10.1093/rheumatology/ket414</pub-id></element-citation></ref><ref id="B7-biomolecules-10-00055"><label>7.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mousavi</surname><given-names>M.J.</given-names></name><name><surname>Jamshidi</surname><given-names>A.</given-names></name><name><surname>Chopra</surname><given-names>A.</given-names></name><name><surname>Aslani</surname><given-names>S.</given-names></name><name><surname>Akhlaghi</surname><given-names>M.</given-names></name><name><surname>Mahmoudi</surname><given-names>M.</given-names></name></person-group><article-title>Implications of the noncoding RNAs in rheumatoid arthritis pathogenesis</article-title><source>J. Cell. Physiol.</source><year>2018</year><volume>234</volume><fpage>335</fpage><lpage>347</lpage><pub-id pub-id-type="doi">10.1002/jcp.26911</pub-id><pub-id pub-id-type="pmid">30069877</pub-id></element-citation></ref><ref id="B8-biomolecules-10-00055"><label>8.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Consortium</surname><given-names>E.P.</given-names></name></person-group><article-title>Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project</article-title><source>Nature</source><year>2007</year><volume>447</volume><fpage>799</fpage><lpage>816</lpage><pub-id pub-id-type="doi">10.1038/nature05874</pub-id><pub-id pub-id-type="pmid">17571346</pub-id></element-citation></ref><ref id="B9-biomolecules-10-00055"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Consortium</surname><given-names>E.P.</given-names></name></person-group><article-title>An integrated encyclopedia of DNA elements in the human genome</article-title><source>Nature</source><year>2012</year><volume>489</volume><fpage>57</fpage><lpage>74</lpage><pub-id pub-id-type="doi">10.1038/nature11247</pub-id><pub-id pub-id-type="pmid">22955616</pub-id></element-citation></ref><ref id="B10-biomolecules-10-00055"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Luo</surname><given-names>Q.</given-names></name><name><surname>Xu</surname><given-names>C.</given-names></name><name><surname>Li</surname><given-names>X.</given-names></name><name><surname>Zeng</surname><given-names>L.</given-names></name><name><surname>Ye</surname><given-names>J.</given-names></name><name><surname>Guo</surname><given-names>Y.</given-names></name><name><surname>Huang</surname><given-names>Z.</given-names></name><name><surname>Li</surname><given-names>J.</given-names></name></person-group><article-title>Comprehensive analysis of long non-coding RNA and mRNA expression profiles in rheumatoid arthritis</article-title><source>Exp. Ther. Med.</source><year>2017</year><volume>14</volume><fpage>5965</fpage><lpage>5973</lpage><pub-id pub-id-type="doi">10.3892/etm.2017.5284</pub-id><pub-id pub-id-type="pmid">29250139</pub-id></element-citation></ref><ref id="B11-biomolecules-10-00055"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mercer</surname><given-names>T.R.</given-names></name><name><surname>Mattick</surname><given-names>J.S.</given-names></name></person-group><article-title>Structure and function of long noncoding RNAs in epigenetic regulation</article-title><source>Nat. Struct. Mol. Biol.</source><year>2013</year><volume>20</volume><fpage>300</fpage><lpage>307</lpage><pub-id pub-id-type="doi">10.1038/nsmb.2480</pub-id><pub-id pub-id-type="pmid">23463315</pub-id></element-citation></ref><ref id="B12-biomolecules-10-00055"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ceppi</surname><given-names>M.</given-names></name><name><surname>Pereira</surname><given-names>P.M.</given-names></name><name><surname>Dunand-Sauthier</surname><given-names>I.</given-names></name><name><surname>Barras</surname><given-names>E.</given-names></name><name><surname>Reith</surname><given-names>W.</given-names></name><name><surname>Santos</surname><given-names>M.A.</given-names></name><name><surname>Pierre</surname><given-names>P.</given-names></name></person-group><article-title>MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells</article-title><source>Proc. Natl. Acad. Sci. USA</source><year>2009</year><volume>106</volume><fpage>2735</fpage><lpage>2740</lpage><pub-id pub-id-type="doi">10.1073/pnas.0811073106</pub-id><pub-id pub-id-type="pmid">19193853</pub-id></element-citation></ref><ref id="B13-biomolecules-10-00055"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Filková</surname><given-names>M.</given-names></name><name><surname>Aradi</surname><given-names>B.</given-names></name><name><surname>Senolt</surname><given-names>L.</given-names></name><name><surname>Ospelt</surname><given-names>C.</given-names></name><name><surname>Vettori</surname><given-names>S.</given-names></name><name><surname>Mann</surname><given-names>H.</given-names></name><name><surname>Filer</surname><given-names>A.</given-names></name><name><surname>Raza</surname><given-names>K.</given-names></name><name><surname>Buckley</surname><given-names>C.D.</given-names></name><name><surname>Snow</surname><given-names>M.</given-names></name><etal></etal></person-group><article-title>Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis</article-title><source>Ann. Rheum. Dis.</source><year>2014</year><volume>73</volume><fpage>1898</fpage><lpage>1904</lpage><pub-id pub-id-type="doi">10.1136/annrheumdis-2012-202815</pub-id><pub-id pub-id-type="pmid">23897768</pub-id></element-citation></ref><ref id="B14-biomolecules-10-00055"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nakamachi</surname><given-names>Y.</given-names></name><name><surname>Kawano</surname><given-names>S.</given-names></name><name><surname>Takenokuchi</surname><given-names>M.</given-names></name><name><surname>Nishimura</surname><given-names>K.</given-names></name><name><surname>Sakai</surname><given-names>Y.</given-names></name><name><surname>Chin</surname><given-names>T.</given-names></name><name><surname>Saura</surname><given-names>R.</given-names></name><name><surname>Kurosaka</surname><given-names>M.</given-names></name><name><surname>Kumagai</surname><given-names>S.</given-names></name></person-group><article-title>MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis</article-title><source>Arthritis Rheum.</source><year>2009</year><volume>60</volume><fpage>1294</fpage><lpage>12304</lpage><pub-id pub-id-type="doi">10.1002/art.24475</pub-id><pub-id pub-id-type="pmid">19404929</pub-id></element-citation></ref><ref id="B15-biomolecules-10-00055"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ma</surname><given-names>H.</given-names></name><name><surname>Hao</surname><given-names>Y.</given-names></name><name><surname>Dong</surname><given-names>X.</given-names></name><name><surname>Gong</surname><given-names>Q.</given-names></name><name><surname>Chen</surname><given-names>J.</given-names></name><name><surname>Zhang</surname><given-names>J.</given-names></name><name><surname>Tian</surname><given-names>W.</given-names></name></person-group><article-title>Molecular mechanisms and function prediction of long noncoding RNA</article-title><source>Sci. World J.</source><year>2012</year><volume>2012</volume><fpage>541786</fpage><pub-id pub-id-type="doi">10.1100/2012/541786</pub-id><pub-id pub-id-type="pmid">23319885</pub-id></element-citation></ref><ref id="B16-biomolecules-10-00055"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>C.</given-names></name><name><surname>Wang</surname><given-names>L.</given-names></name><name><surname>Ding</surname><given-names>Y.</given-names></name><name><surname>Lu</surname><given-names>X.</given-names></name><name><surname>Zhang</surname><given-names>G.</given-names></name><name><surname>Yang</surname><given-names>J.</given-names></name><name><surname>Zheng</surname><given-names>H.</given-names></name><name><surname>Wang</surname><given-names>H.</given-names></name><name><surname>Jiang</surname><given-names>Y.</given-names></name><name><surname>Xu</surname><given-names>L.</given-names></name></person-group><article-title>LncRNA Structural Characteristics in Epigenetic Regulation</article-title><source>Int. J. Mol. Sci.</source><year>2017</year><volume>18</volume><elocation-id>2659</elocation-id><pub-id pub-id-type="doi">10.3390/ijms18122659</pub-id><pub-id pub-id-type="pmid">29292750</pub-id></element-citation></ref><ref id="B17-biomolecules-10-00055"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huarte</surname><given-names>M.</given-names></name><name><surname>Guttman</surname><given-names>M.</given-names></name><name><surname>Feldser</surname><given-names>D.</given-names></name><name><surname>Garber</surname><given-names>M.</given-names></name><name><surname>Koziol</surname><given-names>M.J.</given-names></name><name><surname>Kenzelmann-Broz</surname><given-names>D.</given-names></name><name><surname>Khalil</surname><given-names>A.M.</given-names></name><name><surname>Zuk</surname><given-names>O.</given-names></name></person-group><article-title>A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response</article-title><source>Cell</source><year>2010</year><volume>142</volume><fpage>409</fpage><lpage>419</lpage><pub-id pub-id-type="doi">10.1016/j.cell.2010.06.040</pub-id><pub-id pub-id-type="pmid">20673990</pub-id></element-citation></ref><ref id="B18-biomolecules-10-00055"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>Z.</given-names></name><name><surname>Zhu</surname><given-names>Z.</given-names></name><name><surname>Watabe</surname><given-names>K.</given-names></name><name><surname>Zhang</surname><given-names>X.</given-names></name><name><surname>Bai</surname><given-names>C.</given-names></name><name><surname>Xu</surname><given-names>M.</given-names></name><name><surname>Wu</surname><given-names>F.</given-names></name><name><surname>Mo</surname><given-names>Y.Y.</given-names></name></person-group><article-title>Negative regulation of lncRNA GAS5 by miR-21</article-title><source>Cell Death Differ.</source><year>2013</year><volume>20</volume><fpage>1558</fpage><lpage>1568</lpage><pub-id pub-id-type="doi">10.1038/cdd.2013.110</pub-id><pub-id pub-id-type="pmid">23933812</pub-id></element-citation></ref><ref id="B19-biomolecules-10-00055"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salmena</surname><given-names>L.</given-names></name><name><surname>Poliseno</surname><given-names>L.</given-names></name><name><surname>Tay</surname><given-names>Y.</given-names></name><name><surname>Kats</surname><given-names>L.</given-names></name><name><surname>Pandolfi</surname><given-names>P.P.</given-names></name></person-group><article-title>A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language?</article-title><source>Cell</source><year>2011</year><volume>146</volume><fpage>353</fpage><lpage>358</lpage><pub-id pub-id-type="doi">10.1016/j.cell.2011.07.014</pub-id><pub-id pub-id-type="pmid">21802130</pub-id></element-citation></ref><ref id="B20-biomolecules-10-00055"><label>20.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gupta</surname><given-names>R.A.</given-names></name><name><surname>Shah</surname><given-names>N.</given-names></name><name><surname>Wang</surname><given-names>K.C.</given-names></name><name><surname>Kim</surname><given-names>J.</given-names></name><name><surname>Horlings</surname><given-names>H.M.</given-names></name><name><surname>Wong</surname><given-names>D.J.</given-names></name><name><surname>Tsai</surname><given-names>M.C.</given-names></name><name><surname>Hung</surname><given-names>T.</given-names></name></person-group><article-title>Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis</article-title><source>Nature</source><year>2010</year><volume>464</volume><fpage>1071</fpage><lpage>1076</lpage><pub-id pub-id-type="doi">10.1038/nature08975</pub-id><pub-id pub-id-type="pmid">20393566</pub-id></element-citation></ref><ref id="B21-biomolecules-10-00055"><label>21.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xing</surname><given-names>D.</given-names></name><name><surname>Liang</surname><given-names>J.Q.</given-names></name><name><surname>Li</surname><given-names>Y.</given-names></name><name><surname>Lu</surname><given-names>J.</given-names></name><name><surname>Jia</surname><given-names>H.B.</given-names></name><name><surname>Xu</surname><given-names>L.Y.</given-names></name><name><surname>Ma</surname><given-names>X.L.</given-names></name></person-group><article-title>Identification of long noncoding RNA associated with osteoarthritis in humans</article-title><source>Orthop. Surg.</source><year>2014</year><volume>6</volume><fpage>288</fpage><lpage>293</lpage><pub-id pub-id-type="doi">10.1111/os.12147</pub-id><pub-id pub-id-type="pmid">25430712</pub-id></element-citation></ref><ref id="B22-biomolecules-10-00055"><label>22.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stuhlmüller</surname><given-names>B.</given-names></name><name><surname>Kunisch</surname><given-names>E.</given-names></name><name><surname>Franz</surname><given-names>J.</given-names></name><name><surname>Martinez-Gamboa</surname><given-names>L.</given-names></name><name><surname>Hernandez</surname><given-names>M.M.</given-names></name><name><surname>Pruss</surname><given-names>A.</given-names></name><name><surname>Ulbrich</surname><given-names>N.</given-names></name><name><surname>Erdmann</surname><given-names>V.A.</given-names></name><name><surname>Burmester</surname><given-names>G.R.</given-names></name><name><surname>Kinne</surname><given-names>R.W.</given-names></name></person-group><article-title>Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue</article-title><source>Am. J. Pathol.</source><year>2003</year><volume>163</volume><fpage>901</fpage><lpage>911</lpage><pub-id pub-id-type="doi">10.1016/S0002-9440(10)63450-5</pub-id><pub-id pub-id-type="pmid">12937131</pub-id></element-citation></ref><ref id="B23-biomolecules-10-00055"><label>23.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>Y.</given-names></name><name><surname>Zhang</surname><given-names>F.</given-names></name><name><surname>Ma</surname><given-names>J.</given-names></name><name><surname>Zhang</surname><given-names>X.</given-names></name><name><surname>Wu</surname><given-names>L.</given-names></name><name><surname>Qu</surname><given-names>B.</given-names></name><name><surname>Xia</surname><given-names>S.</given-names></name><name><surname>Chen</surname><given-names>S.</given-names></name><name><surname>Tang</surname><given-names>Y.</given-names></name><name><surname>Shen</surname><given-names>N.</given-names></name></person-group><article-title>Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus</article-title><source>Arthritis Res. Ther.</source><year>2015</year><volume>17</volume><fpage>131</fpage><pub-id pub-id-type="doi">10.1186/s13075-015-0632-3</pub-id><pub-id pub-id-type="pmid">25994030</pub-id></element-citation></ref><ref id="B24-biomolecules-10-00055"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schneider</surname><given-names>C.</given-names></name><name><surname>King</surname><given-names>R.M.</given-names></name><name><surname>Philipson</surname><given-names>L.</given-names></name></person-group><article-title>Genes specifically expressed at growth arrest of mammalian cells</article-title><source>Cell</source><year>1988</year><volume>54</volume><fpage>787</fpage><lpage>793</lpage><pub-id pub-id-type="doi">10.1016/S0092-8674(88)91065-3</pub-id><pub-id pub-id-type="pmid">3409319</pub-id></element-citation></ref><ref id="B25-biomolecules-10-00055"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mayama</surname><given-names>T.</given-names></name><name><surname>Marr</surname><given-names>A.K.</given-names></name><name><surname>Kino</surname><given-names>T.</given-names></name></person-group><article-title>Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases</article-title><source>Horm. Metab. Res.</source><year>2016</year><volume>48</volume><fpage>550</fpage><lpage>557</lpage><pub-id pub-id-type="doi">10.1055/s-0042-106898</pub-id><pub-id pub-id-type="pmid">27214311</pub-id></element-citation></ref><ref id="B26-biomolecules-10-00055"><label>26.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moharamoghli</surname><given-names>M.</given-names></name><name><surname>Hassan-Zadeh</surname><given-names>V.</given-names></name><name><surname>Dolatshahi</surname><given-names>E.</given-names></name><name><surname>Alizadeh</surname><given-names>Z.</given-names></name><name><surname>Farazmand</surname><given-names>A.</given-names></name></person-group><article-title>The expression of GAS5, THRIL, and RMRP lncRNAs is increased in T cells of patients with rheumatoid arthritis</article-title><source>Clin. Rheumatol.</source><year>2019</year><pub-id pub-id-type="doi">10.1007/s10067-019-04694-z</pub-id></element-citation></ref><ref id="B27-biomolecules-10-00055"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arnett</surname><given-names>F.C.</given-names></name><name><surname>Edworthy</surname><given-names>S.M.</given-names></name><name><surname>Bloch</surname><given-names>D.A.</given-names></name><name><surname>McShane</surname><given-names>D.J.</given-names></name><name><surname>Fries</surname><given-names>J.F.</given-names></name><name><surname>Cooper</surname><given-names>N.S.</given-names></name><name><surname>Healey</surname><given-names>L.A.</given-names></name><name><surname>Kaplan</surname><given-names>S.R.</given-names></name><name><surname>Liang</surname><given-names>M.H.</given-names></name><name><surname>Luthra</surname><given-names>H.S.</given-names></name></person-group><article-title>The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis</article-title><source>Arthritis Rheum.</source><year>1988</year><volume>31</volume><fpage>315</fpage><lpage>324</lpage><pub-id pub-id-type="doi">10.1002/art.1780310302</pub-id><pub-id pub-id-type="pmid">3358796</pub-id></element-citation></ref><ref id="B28-biomolecules-10-00055"><label>28.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuriya</surname><given-names>B.</given-names></name><name><surname>Schieir</surname><given-names>O.</given-names></name><name><surname>Lin</surname><given-names>D.</given-names></name><name><surname>Xiong</surname><given-names>J.</given-names></name><name><surname>Pope</surname><given-names>J.</given-names></name><name><surname>Boire</surname><given-names>G.</given-names></name><name><surname>Haraoui</surname><given-names>B.</given-names></name><name><surname>Thorne</surname><given-names>J.C.</given-names></name><name><surname>Tin</surname><given-names>D.</given-names></name><name><surname>Hitchon</surname><given-names>C.</given-names></name><etal></etal></person-group><article-title>Thresholds for the 28-joint disease activity score (DAS28) using C-reactive protein are lower compared to DAS28 using erythrocyte sedimentation rate in early rheumatoid arthritis</article-title><source>Clin. Exp. Rheumatol.</source><year>2017</year><volume>35</volume><fpage>799</fpage><lpage>803</lpage><pub-id pub-id-type="doi">10.1136/annrheumdis-2016-eular.2937</pub-id><pub-id pub-id-type="pmid">28339365</pub-id></element-citation></ref><ref id="B29-biomolecules-10-00055"><label>29.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sahu</surname><given-names>A.</given-names></name><name><surname>Singhal</surname><given-names>U.</given-names></name><name><surname>Chinnaiyan</surname><given-names>A.M.</given-names></name></person-group><article-title>Long noncoding RNAs in cancer: From function to translation</article-title><source>Trends Cancer</source><year>2015</year><volume>1</volume><fpage>93</fpage><lpage>109</lpage><pub-id pub-id-type="doi">10.1016/j.trecan.2015.08.010</pub-id><pub-id pub-id-type="pmid">26693181</pub-id></element-citation></ref><ref id="B30-biomolecules-10-00055"><label>30.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Steck</surname><given-names>E.</given-names></name><name><surname>Boeuf</surname><given-names>S.</given-names></name><name><surname>Gabler</surname><given-names>J.</given-names></name><name><surname>Werth</surname><given-names>N.</given-names></name><name><surname>Schnatzer</surname><given-names>P.</given-names></name><name><surname>Diederichs</surname><given-names>S.</given-names></name><name><surname>Richter</surname><given-names>W.</given-names></name></person-group><article-title>Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions</article-title><source>J. Mol. Med. (Berl.)</source><year>2012</year><volume>90</volume><fpage>1185</fpage><lpage>1195</lpage><pub-id pub-id-type="doi">10.1007/s00109-012-0895-y</pub-id><pub-id pub-id-type="pmid">22527881</pub-id></element-citation></ref><ref id="B31-biomolecules-10-00055"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Song</surname><given-names>J.</given-names></name><name><surname>Kim</surname><given-names>D.</given-names></name><name><surname>Han</surname><given-names>J.</given-names></name><name><surname>Kim</surname><given-names>Y.</given-names></name><name><surname>Lee</surname><given-names>M.</given-names></name><name><surname>Jin</surname><given-names>E.J.</given-names></name></person-group><article-title>PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis</article-title><source>Clin. Exp. Med.</source><year>2015</year><volume>15</volume><fpage>121</fpage><lpage>126</lpage><pub-id pub-id-type="doi">10.1007/s10238-013-0271-4</pub-id><pub-id pub-id-type="pmid">24722995</pub-id></element-citation></ref><ref id="B32-biomolecules-10-00055"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kino</surname><given-names>T.</given-names></name><name><surname>Hurt</surname><given-names>D.E.</given-names></name><name><surname>Ichijo</surname><given-names>T.</given-names></name><name><surname>Nader</surname><given-names>N.</given-names></name><name><surname>Chrousos</surname><given-names>G.P.</given-names></name></person-group><article-title>Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor</article-title><source>Sci. Signal.</source><year>2010</year><volume>3</volume><fpage>ra8</fpage><pub-id pub-id-type="doi">10.1126/scisignal.2000568</pub-id><pub-id pub-id-type="pmid">20124551</pub-id></element-citation></ref><ref id="B33-biomolecules-10-00055"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>G.C.</given-names></name><name><surname>Li</surname><given-names>J.</given-names></name><name><surname>Leng</surname><given-names>R.X.</given-names></name><name><surname>Li</surname><given-names>X.P.</given-names></name><name><surname>Li</surname><given-names>X.M.</given-names></name><name><surname>Wang</surname><given-names>D.G.</given-names></name><name><surname>Pan</surname><given-names>H.F.</given-names></name><name><surname>Ye</surname><given-names>D.Q.</given-names></name></person-group><article-title>Identification of long non-coding RNAs GAS5, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus</article-title><source>Oncotarget</source><year>2017</year><volume>8</volume><fpage>23650</fpage><lpage>23663</lpage><pub-id pub-id-type="doi">10.18632/oncotarget.15569</pub-id><pub-id pub-id-type="pmid">28423570</pub-id></element-citation></ref><ref id="B34-biomolecules-10-00055"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sigdel</surname><given-names>K.R.</given-names></name><name><surname>Cheng</surname><given-names>A.</given-names></name><name><surname>Wang</surname><given-names>Y.</given-names></name><name><surname>Duan</surname><given-names>L.</given-names></name><name><surname>Zhang</surname><given-names>Y.</given-names></name></person-group><article-title>The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases</article-title><source>J. Immunol. Res.</source><year>2015</year><volume>2015</volume><fpage>848790</fpage><pub-id pub-id-type="doi">10.1155/2015/848790</pub-id><pub-id pub-id-type="pmid">26090502</pub-id></element-citation></ref><ref id="B35-biomolecules-10-00055"><label>35.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>K.W.</given-names></name><name><surname>Kim</surname><given-names>B.M.</given-names></name><name><surname>Moon</surname><given-names>H.W.</given-names></name><name><surname>Lee</surname><given-names>S.H.</given-names></name><name><surname>Kim</surname><given-names>H.R.</given-names></name></person-group><article-title>Role of C-reactive protein in osteoclastogenesis in rheumatoid arthritis</article-title><source>Arthritis Res. Ther.</source><year>2015</year><volume>17</volume><fpage>41</fpage><pub-id pub-id-type="doi">10.1186/s13075-015-0563-z</pub-id><pub-id pub-id-type="pmid">25889630</pub-id></element-citation></ref><ref id="B36-biomolecules-10-00055"><label>36.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Holers</surname><given-names>V.M.</given-names></name><name><surname>Bana</surname><given-names>N.K.</given-names></name></person-group><article-title>Complement in the Initiation and Evolution of Rheumatoid Arthritis</article-title><source>Front. Immunol.</source><year>2018</year><volume>9</volume><fpage>1057</fpage><pub-id pub-id-type="doi">10.3389/fimmu.2018.01057</pub-id><pub-id pub-id-type="pmid">29892280</pub-id></element-citation></ref><ref id="B37-biomolecules-10-00055"><label>37.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Choy</surname><given-names>E.H.</given-names></name><name><surname>Isenberg</surname><given-names>D.A.</given-names></name><name><surname>Garrood</surname><given-names>T.</given-names></name><name><surname>Farrow</surname><given-names>S.</given-names></name><name><surname>Ioannou</surname><given-names>Y.</given-names></name><name><surname>Bird</surname><given-names>H.</given-names></name><name><surname>Cheung</surname><given-names>N.</given-names></name><name><surname>Williams</surname><given-names>B.</given-names></name><name><surname>Hazleman</surname><given-names>B.</given-names></name><name><surname>Price</surname><given-names>R.</given-names></name><etal></etal></person-group><article-title>Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, double-blind, placebo-controlled, dose-escalation trial</article-title><source>Arthritis Rheum.</source><year>2002</year><volume>46</volume><fpage>3143</fpage><lpage>3150</lpage><pub-id pub-id-type="doi">10.1002/art.10623</pub-id><pub-id pub-id-type="pmid">12483717</pub-id></element-citation></ref><ref id="B38-biomolecules-10-00055"><label>38.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nishimoto</surname><given-names>N.</given-names></name><name><surname>Yoshizaki</surname><given-names>K.</given-names></name><name><surname>Miyasaka</surname><given-names>N.</given-names></name><name><surname>Yamamoto</surname><given-names>K.</given-names></name><name><surname>Kawai</surname><given-names>S.</given-names></name><name><surname>Takeuchi</surname><given-names>T.</given-names></name><name><surname>Hashimoto</surname><given-names>J.</given-names></name><name><surname>Azuma</surname><given-names>J.</given-names></name><name><surname>Kishimoto</surname><given-names>T.</given-names></name></person-group><article-title>Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebo-controlled trial</article-title><source>Arthritis Rheum.</source><year>2004</year><volume>50</volume><fpage>1761</fpage><lpage>1769</lpage><pub-id pub-id-type="doi">10.1002/art.20303</pub-id><pub-id pub-id-type="pmid">15188351</pub-id></element-citation></ref><ref id="B39-biomolecules-10-00055"><label>39.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>Z.</given-names></name><name><surname>Chao</surname><given-names>T.C.</given-names></name><name><surname>Chang</surname><given-names>K.Y.</given-names></name><name><surname>Lin</surname><given-names>N.</given-names></name><name><surname>Patil</surname><given-names>V.S.</given-names></name><name><surname>Shimizu</surname><given-names>C.</given-names></name><name><surname>Head</surname><given-names>S.R.</given-names></name><name><surname>Burns</surname><given-names>J.C.</given-names></name><name><surname>Rana</surname><given-names>T.M.</given-names></name></person-group><article-title>The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL</article-title><source>Proc. Natl. Acad. Sci. USA</source><year>2014</year><volume>111</volume><fpage>1002</fpage><lpage>1007</lpage><pub-id pub-id-type="doi">10.1073/pnas.1313768111</pub-id><pub-id pub-id-type="pmid">24371310</pub-id></element-citation></ref><ref id="B40-biomolecules-10-00055"><label>40.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>Q.</given-names></name><name><surname>Ma</surname><given-names>G.</given-names></name><name><surname>Sun</surname><given-names>S.H.</given-names></name><name><surname>Xu</surname><given-names>Y.</given-names></name><name><surname>Wang</surname><given-names>B.</given-names></name></person-group><article-title>Polymorphism in the promoter region of lncRNA GAS5 is functionally associated with the risk of gastric cancer</article-title><source>Clin. Res. Hepatol. Gastroenterol.</source><year>2018</year><volume>42</volume><fpage>478</fpage><lpage>482</lpage><pub-id pub-id-type="doi">10.1016/j.clinre.2018.01.006</pub-id><pub-id pub-id-type="pmid">29602737</pub-id></element-citation></ref><ref id="B41-biomolecules-10-00055"><label>41.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guo</surname><given-names>Z.</given-names></name><name><surname>Wang</surname><given-names>Y.</given-names></name><name><surname>Zhao</surname><given-names>Y.</given-names></name><name><surname>Jin</surname><given-names>Y.</given-names></name><name><surname>An</surname><given-names>L.</given-names></name><name><surname>Wu</surname><given-names>B.</given-names></name><name><surname>Liu</surname><given-names>Z.</given-names></name><name><surname>Chen</surname><given-names>X.</given-names></name><name><surname>Zhou</surname><given-names>H.</given-names></name><name><surname>Wang</surname><given-names>H.</given-names></name><etal></etal></person-group><article-title>Genetic polymorphisms of long non-coding RNA GAS5 predict platinum-based concurrent chemoradiotherapy response in nasopharyngeal carcinoma patients</article-title><source>Oncotarget</source><year>2017</year><volume>8</volume><fpage>62286</fpage><lpage>62297</lpage><pub-id pub-id-type="doi">10.18632/oncotarget.19725</pub-id><pub-id pub-id-type="pmid">28977945</pub-id></element-citation></ref><ref id="B42-biomolecules-10-00055"><label>42.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>W.</given-names></name><name><surname>Huang</surname><given-names>K.</given-names></name><name><surname>Wen</surname><given-names>F.</given-names></name><name><surname>Cui</surname><given-names>G.</given-names></name><name><surname>Guo</surname><given-names>H.</given-names></name><name><surname>Zhao</surname><given-names>S.</given-names></name></person-group><article-title>Genetic variation of lncRNA GAS5 contributes to the development of lung cancer</article-title><source>Oncotarget</source><year>2017</year><volume>8</volume><fpage>91025</fpage><lpage>91029</lpage><pub-id pub-id-type="doi">10.18632/oncotarget.19955</pub-id><pub-id pub-id-type="pmid">29207621</pub-id></element-citation></ref><ref id="B43-biomolecules-10-00055"><label>43.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mahdi Eftekharian</surname><given-names>M.</given-names></name><name><surname>Noroozi</surname><given-names>R.</given-names></name><name><surname>Komaki</surname><given-names>A.</given-names></name><name><surname>Mazdeh</surname><given-names>M.</given-names></name><name><surname>Taheri</surname><given-names>M.</given-names></name><name><surname>Ghafouri-Fard</surname><given-names>S.</given-names></name></person-group><article-title>GAS5 genomic variants and risk of multiple sclerosis</article-title><source>Neurosci. Lett.</source><year>2019</year><volume>701</volume><fpage>54</fpage><lpage>57</lpage><pub-id pub-id-type="doi">10.1016/j.neulet.2019.02.028</pub-id><pub-id pub-id-type="pmid">30790644</pub-id></element-citation></ref><ref id="B44-biomolecules-10-00055"><label>44.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sun</surname><given-names>D.</given-names></name><name><surname>Yu</surname><given-names>Z.</given-names></name><name><surname>Fang</surname><given-names>X.</given-names></name><name><surname>Liu</surname><given-names>M.</given-names></name><name><surname>Pu</surname><given-names>Y.</given-names></name><name><surname>Shao</surname><given-names>Q.</given-names></name><name><surname>Wang</surname><given-names>D.</given-names></name><name><surname>Zhao</surname><given-names>X.</given-names></name><name><surname>Huang</surname><given-names>A.</given-names></name><name><surname>Xiang</surname><given-names>Z.</given-names></name></person-group><article-title>LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination</article-title><source>EMBO Rep.</source><year>2017</year><volume>18</volume><fpage>1801</fpage><lpage>1816</lpage><pub-id pub-id-type="doi">10.15252/embr.201643668</pub-id><pub-id pub-id-type="pmid">28808113</pub-id></element-citation></ref><ref id="B45-biomolecules-10-00055"><label>45.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gao</surname><given-names>P.</given-names></name><name><surname>Xia</surname><given-names>J.H.</given-names></name><name><surname>Sipeky</surname><given-names>C.</given-names></name><name><surname>Dong</surname><given-names>X.M.</given-names></name><name><surname>Zhang</surname><given-names>Q.</given-names></name><name><surname>Yang</surname><given-names>Y.</given-names></name><name><surname>Zhang</surname><given-names>P.</given-names></name><name><surname>Cruz</surname><given-names>S.P.</given-names></name><name><surname>Zhang</surname><given-names>K.</given-names></name><name><surname>Zhu</surname><given-names>J.</given-names></name><etal></etal></person-group><article-title>Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus</article-title><source>Cell</source><year>2018</year><volume>174</volume><fpage>576</fpage><lpage>589</lpage><pub-id pub-id-type="doi">10.1016/j.cell.2018.06.003</pub-id><pub-id pub-id-type="pmid">30033361</pub-id></element-citation></ref><ref id="B46-biomolecules-10-00055"><label>46.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hua</surname><given-names>J.T.</given-names></name><name><surname>Ahmed</surname><given-names>M.</given-names></name><name><surname>Guo</surname><given-names>H.</given-names></name><name><surname>Zhang</surname><given-names>Y.</given-names></name><name><surname>Chen</surname><given-names>S.</given-names></name><name><surname>Soares</surname><given-names>F.</given-names></name><name><surname>Lu</surname><given-names>J.</given-names></name><name><surname>Zhou</surname><given-names>S.</given-names></name><name><surname>Wang</surname><given-names>M.</given-names></name><name><surname>Li</surname><given-names>H.</given-names></name><etal></etal></person-group><article-title>Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19</article-title><source>Cell</source><year>2018</year><volume>174</volume><fpage>564</fpage><lpage>575</lpage><pub-id pub-id-type="doi">10.1016/j.cell.2018.06.014</pub-id><pub-id pub-id-type="pmid">30033362</pub-id></element-citation></ref><ref id="B47-biomolecules-10-00055"><label>47.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>A.F.</given-names></name><name><surname>Su</surname><given-names>L.C.</given-names></name><name><surname>Jia</surname><given-names>H.</given-names></name><name><surname>Liu</surname><given-names>Y.</given-names></name><name><surname>Xu</surname><given-names>W.D.</given-names></name></person-group><article-title>No association of single nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and primary Sjogren’s syndrome in a Chinese Han population</article-title><source>Clin. Rheumatol.</source><year>2017</year><volume>36</volume><fpage>2447</fpage><lpage>2453</lpage><pub-id pub-id-type="doi">10.1007/s10067-017-3833-0</pub-id><pub-id pub-id-type="pmid">28914367</pub-id></element-citation></ref><ref id="B48-biomolecules-10-00055"><label>48.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhou</surname><given-names>J.Z.</given-names></name><name><surname>Li</surname><given-names>J.J.</given-names></name><name><surname>Hua</surname><given-names>D.J.</given-names></name><name><surname>Huang</surname><given-names>S.C.</given-names></name><name><surname>Sun</surname><given-names>Q.Q.</given-names></name><name><surname>Huang</surname><given-names>H.</given-names></name><name><surname>Xin</surname><given-names>X.F.</given-names></name><name><surname>Cen</surname><given-names>H.</given-names></name></person-group><article-title>A study on associations of single-nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to rheumatoid arthritis in a Chinese population</article-title><source>Inflamm. Res.</source><year>2017</year><volume>66</volume><fpage>515</fpage><lpage>521</lpage><pub-id pub-id-type="doi">10.1007/s00011-017-1035-5</pub-id><pub-id pub-id-type="pmid">28314879</pub-id></element-citation></ref><ref id="B49-biomolecules-10-00055"><label>49.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname><given-names>M.C.</given-names></name><name><surname>Yu</surname><given-names>H.C.</given-names></name><name><surname>Yu</surname><given-names>C.L.</given-names></name><name><surname>Huang</surname><given-names>H.B.</given-names></name><name><surname>Koo</surname><given-names>M.</given-names></name><name><surname>Tung</surname><given-names>C.H.</given-names></name><name><surname>Lai</surname><given-names>N.S.</given-names></name></person-group><article-title>Increased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses</article-title><source>Immunol. Res.</source><year>2016</year><volume>64</volume><fpage>576</fpage><lpage>583</lpage><pub-id pub-id-type="doi">10.1007/s12026-015-8756-8</pub-id><pub-id pub-id-type="pmid">26616293</pub-id></element-citation></ref><ref id="B50-biomolecules-10-00055"><label>50.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ye</surname><given-names>S.</given-names></name><name><surname>Patodi</surname><given-names>N.</given-names></name><name><surname>Walker-Bone</surname><given-names>K.</given-names></name><name><surname>Reading</surname><given-names>I.</given-names></name><name><surname>Cooper</surname><given-names>C.</given-names></name><name><surname>Dennison</surname><given-names>E.</given-names></name></person-group><article-title>Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis</article-title><source>Int. J. Immunogenet.</source><year>2007</year><volume>34</volume><fpage>81</fpage><lpage>85</lpage><pub-id pub-id-type="doi">10.1111/j.1744-313X.2007.00664.x</pub-id><pub-id pub-id-type="pmid">17373931</pub-id></element-citation></ref><ref id="B51-biomolecules-10-00055"><label>51.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Spurlock</surname><given-names>C.F.</given-names><suffix>3rd</suffix></name><name><surname>Tossberg</surname><given-names>J.T.</given-names></name><name><surname>Matlock</surname><given-names>B.K.</given-names></name><name><surname>Olsen</surname><given-names>N.J.</given-names></name><name><surname>Aune</surname><given-names>T.M.</given-names></name></person-group><article-title>Methotrexate inhibits NF-kappaB activity via long intergenic (noncoding) RNA-p21 induction</article-title><source>Arthritis Rheumatol. (Hoboken NJ)</source><year>2014</year><volume>66</volume><fpage>2947</fpage><lpage>2957</lpage><pub-id pub-id-type="doi">10.1002/art.38805</pub-id><pub-id pub-id-type="pmid">25077978</pub-id></element-citation></ref><ref id="B52-biomolecules-10-00055"><label>52.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Messemaker</surname><given-names>T.C.</given-names></name><name><surname>Frank-Bertoncelj</surname><given-names>M.</given-names></name><name><surname>Marques</surname><given-names>R.B.</given-names></name><name><surname>Adriaans</surname><given-names>A.</given-names></name><name><surname>Bakker</surname><given-names>A.M.</given-names></name><name><surname>Daha</surname><given-names>N.</given-names></name><name><surname>Gay</surname><given-names>S.</given-names></name><name><surname>Huizinga</surname><given-names>T.W.</given-names></name><name><surname>Toes</surname><given-names>R.E.</given-names></name><name><surname>Mikkers</surname><given-names>H.M.</given-names></name><etal></etal></person-group><article-title>A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels</article-title><source>Genes Immun.</source><year>2016</year><volume>17</volume><fpage>85</fpage><lpage>92</lpage><pub-id pub-id-type="doi">10.1038/gene.2015.54</pub-id><pub-id pub-id-type="pmid">26673966</pub-id></element-citation></ref><ref id="B53-biomolecules-10-00055"><label>53.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Müller</surname><given-names>N.</given-names></name><name><surname>Doring</surname><given-names>F.</given-names></name><name><surname>Klapper</surname><given-names>M.</given-names></name><name><surname>Neumann</surname><given-names>K.</given-names></name><name><surname>Schulte</surname><given-names>D.M.</given-names></name><name><surname>Türk</surname><given-names>K.</given-names></name><name><surname>Schröder</surname><given-names>J.O.</given-names></name><name><surname>Zeuner</surname><given-names>R.A.</given-names></name><name><surname>Freitag-Wolf</surname><given-names>S.</given-names></name><name><surname>Schreiber</surname><given-names>S.</given-names></name><etal></etal></person-group><article-title>Interleukin-6 and tumour necrosis factor-alpha differentially regulate lincRNA transcripts in cells of the innate immune system in vivo in human subjects with rheumatoid arthritis</article-title><source>Cytokine</source><year>2014</year><volume>68</volume><fpage>65</fpage><lpage>68</lpage><pub-id pub-id-type="doi">10.1016/j.cyto.2014.03.004</pub-id><pub-id pub-id-type="pmid">24721042</pub-id></element-citation></ref><ref id="B54-biomolecules-10-00055"><label>54.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moran</surname><given-names>V.A.</given-names></name><name><surname>Perera</surname><given-names>R.J.</given-names></name><name><surname>Khalil</surname><given-names>A.M.</given-names></name></person-group><article-title>Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs</article-title><source>Nucleic Acids Res.</source><year>2012</year><volume>40</volume><fpage>6391</fpage><lpage>6400</lpage><pub-id pub-id-type="doi">10.1093/nar/gks296</pub-id><pub-id pub-id-type="pmid">22492512</pub-id></element-citation></ref><ref id="B55-biomolecules-10-00055"><label>55.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khorkova</surname><given-names>O.</given-names></name><name><surname>Hsiao</surname><given-names>J.</given-names></name><name><surname>Wahlestedt</surname><given-names>C.</given-names></name></person-group><article-title>Basic biology and therapeutic implications of lncRNA</article-title><source>Adv. Drug. Deliv. Rev.</source><year>2015</year><volume>87</volume><fpage>15</fpage><lpage>24</lpage><pub-id pub-id-type="doi">10.1016/j.addr.2015.05.012</pub-id><pub-id pub-id-type="pmid">26024979</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="biomolecules-10-00055-f001" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Comparison of GAS5, linc0597 and H19 expression levels in PBMCs between RA patients and controls. (<bold>a</bold>) Decreased GAS5 level in RA patients compared with controls; (<bold>b</bold>) Decreased linc0597 level in RA patients compared with controls; (<bold>c</bold>) Decreased H19 level in RA patients compared with controls. Data for lncRNAs expression levels were presented as median (interquartile range) (* <italic>p</italic> < 0.05, *** <italic>p</italic> < 0.001). RA, rheumatoid arthritis; HC, controls; PBMCs, peripheral blood mononuclear cells.</p></caption><graphic xlink:href="biomolecules-10-00055-g001"></graphic></fig><table-wrap id="biomolecules-10-00055-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t001_Table 1</object-id><label>Table 1</label><caption><p>Primers used in real time quantitative PCR experiment.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">RNAs</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Primers</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">H19</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′TGCTGCACTTTACAACCACTG3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′ATGGTGTCTTTGATGTTGGGC3′</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">GAS5</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′TATGGTGCTGGGTGCGGAT3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′CCAATGGCTTGAGTTAGGCTT3′</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">linc0597</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′TTGGATTCATCCCGTTCACCTCCA3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′CAGCATGACGATCAAGCGAGATTC3′</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">β-actin</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′CACGAAACTACCTTCAACTCC3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′CATACTCCTGCTTGCTGATC3′</td></tr></tbody></table></table-wrap><table-wrap id="biomolecules-10-00055-t002" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t002_Table 2</object-id><label>Table 2</label><caption><p>Associations between lncRNAs expression and categorical laboratory parameters in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Parameters</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Number</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">GAS5</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">linc0597</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">H19</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">RF</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Positive</td><td align="center" valign="middle" rowspan="1" colspan="1">69</td><td align="center" valign="middle" rowspan="1" colspan="1">0.50 (0.34, 0.72)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.62 (0.47, 0.78)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.56 (0.35, 0.82)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Negative</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.52 (0.33, 0.92)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.54 (0.34, 0.86)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.57 (0.16, 1.18)</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Anti-CCP</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Positive</td><td align="center" valign="middle" rowspan="1" colspan="1">65</td><td align="center" valign="middle" rowspan="1" colspan="1">0.51 (0.35, 0.74)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.47, 0.79)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.35, 0.83)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Negative</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.34 (0.25, 0.77)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.63 (0.37, 0.73)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.36 (0.17, 0.74)</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Low complement</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Positive</td><td align="center" valign="middle" rowspan="1" colspan="1">14</td><td align="center" valign="middle" rowspan="1" colspan="1">0.35 (0.21, 0.46)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.50 (0.41, 0.69)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.52 (0.27, 1.23)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Negative</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">52</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.53 (0.34, 0.77)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.62 (0.53, 0.80)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.60 (0.36, 0.82)</td></tr></tbody></table><table-wrap-foot><fn><p>Anti-CCP, anti-cyclic citrullinated peptide; RF, rheumatoid factor; RA, rheumatoid arthritis.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t003" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t003_Table 3</object-id><label>Table 3</label><caption><p>Correlations of lncRNAs expression with continuous laboratory parameters and degree of disease activity in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Parameters</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">GAS5</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">linc0597</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">H19</th></tr><tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">ESR</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.072</td><td align="center" valign="middle" rowspan="1" colspan="1">0.535</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.114</td><td align="center" valign="middle" rowspan="1" colspan="1">0.325</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.150</td><td align="center" valign="middle" rowspan="1" colspan="1">0.196</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">CRP</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.273</td><td align="center" valign="middle" rowspan="1" colspan="1">0.017</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.096</td><td align="center" valign="middle" rowspan="1" colspan="1">0.411</td><td align="center" valign="middle" rowspan="1" colspan="1">0.002</td><td align="center" valign="middle" rowspan="1" colspan="1">0.986</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">TJC</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.020</td><td align="center" valign="middle" rowspan="1" colspan="1">0.866</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.091</td><td align="center" valign="middle" rowspan="1" colspan="1">0.435</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.192</td><td align="center" valign="middle" rowspan="1" colspan="1">0.097</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">SJC</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.054</td><td align="center" valign="middle" rowspan="1" colspan="1">0.648</td><td align="center" valign="middle" rowspan="1" colspan="1">0.052</td><td align="center" valign="middle" rowspan="1" colspan="1">0.660</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.110</td><td align="center" valign="middle" rowspan="1" colspan="1">0.924</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DAS28-ESR</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.112</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.337</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.012</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.920</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.166</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.153</td></tr></tbody></table><table-wrap-foot><fn><p>DAS28-ESR, 28-joint disease activity score using erythrocyte sedimentation rate; CRP, C-reaction. protein; ESR, erythrocyte sedimentation rate; TJC, tender joint count; SJC, swollen joint count.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t004" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t004_Table 4</object-id><label>Table 4</label><caption><p>Influence of main clinical medication on lncRNAs expression in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Group</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Number</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">GAS5</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">linc0597</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">H19</th></tr></thead><tbody><tr><td colspan="2" align="center" valign="middle" rowspan="1">Prednisone (mg/day)</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">≤7.5</td><td align="center" valign="middle" rowspan="1" colspan="1">36</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.37, 0.94)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.46, 0.81)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.58 (0.30, 0.87)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">>7.5</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">37</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.42 (0.34, 0.68)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.62 (0.48, 0.78)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.55 (0.31, 0.82)</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">DMARDS</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td><td align="center" valign="middle" rowspan="1" colspan="1">44</td><td align="center" valign="middle" rowspan="1" colspan="1">0.51 (0.36, 0.81)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.62 (0.47, 0.78)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.34, 0.84)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">No</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">29</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.53 (0.34, 0.69)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.59 (0.47, 0.80)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.43 (0.29, 0.84)</td></tr><tr><td colspan="2" align="center" valign="middle" rowspan="1">Botanical preparation</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td><td align="center" valign="middle" rowspan="1" colspan="1">22</td><td align="center" valign="middle" rowspan="1" colspan="1">0.51 (0.36, 0.84)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.63 (0.46, 0.82)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.59 (0.46, 1.13)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">No</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">51</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.53 (0.34, 0.76)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.62 (0.48, 0.79)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.49 (0.27, 0.80)</td></tr></tbody></table><table-wrap-foot><fn><p>DMARDS, disease modifying antirheumatic drugs.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t005" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t005_Table 5</object-id><label>Table 5</label><caption><p>Allele and genotype frequencies of fourteen SNPs in RA patients and controls.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">SNPs</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Analysis Model</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">RA <italic>n</italic>(%)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">HC <italic>n</italic>(%)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>χ</italic><sup>2</sup></th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>OR</italic> (95% <italic>CI</italic>)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic><sub>ad</sub><sub>just</sub> Value</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6790</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">362 (43.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">316 (40.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.103</td><td align="center" valign="middle" rowspan="1" colspan="1">0.848 (0.623–1.154)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.294</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA</td><td align="center" valign="middle" rowspan="1" colspan="1">333 (40.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">365 (47.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">6.132</td><td align="center" valign="middle" rowspan="1" colspan="1">0.679 (0.499–0.922)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.013</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">130 (15.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">94 (12.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1057 (63.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">997 (63.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.024</td><td align="center" valign="middle" rowspan="1" colspan="1">0.989 (0.856–1.142)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.877</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">593 (36.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">553 (36.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA + GA</td><td align="center" valign="middle" rowspan="1" colspan="1">463 (56.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">459 (59.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.630</td><td align="center" valign="middle" rowspan="1" colspan="1">0.878 (0.719–1.072)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.202</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">362 (43.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">316 (40.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">130 (15.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">94 (12.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">3.578</td><td align="center" valign="middle" rowspan="1" colspan="1">1.321 (0.990–1.762)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.059</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GA + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">695 (84.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">681 (87.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2067051</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotypes</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">101 (12.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">80 (10.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.059</td><td align="center" valign="middle" rowspan="1" colspan="1">1.189 (0.855–1.653)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.303</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TC</td><td align="center" valign="middle" rowspan="1" colspan="1">335 (41.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">306 (41.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.140</td><td align="center" valign="middle" rowspan="1" colspan="1">1.042 (0.842–1.289)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.708</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">380 (46.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">360 (48.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">T</td><td align="center" valign="middle" rowspan="1" colspan="1">537 (33.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">466 (31.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.998</td><td align="center" valign="middle" rowspan="1" colspan="1">1.080 (0.929–1.255)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.318</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1095 (67.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1026 (68.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT + TC</td><td align="center" valign="middle" rowspan="1" colspan="1">436 (53.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">386 (51.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.464</td><td align="center" valign="middle" rowspan="1" colspan="1">1.072 (0.878–1.130)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.496</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">380 (46.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">360 (48.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">101 (12.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">80 (10.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.923</td><td align="center" valign="middle" rowspan="1" colspan="1">1.167 (0.852–1.598)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.337</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TC + CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">715 (87.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">666 (89.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2070107</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">576 (69.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">549 (72.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.022</td><td align="center" valign="middle" rowspan="1" colspan="1">0.955 (0.522–1.747)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.881</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GC</td><td align="center" valign="middle" rowspan="1" colspan="1">233 (28.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">193 (25.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.089</td><td align="center" valign="middle" rowspan="1" colspan="1">1.100 (0.590–2.050)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.765</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">23 (2.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">21 (2.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1385(83.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1291(84.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.100</td><td align="center" valign="middle" rowspan="1" colspan="1">0.904 (0.748–1.092)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.294</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">279 (16.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">235 (15.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GC + CC</td><td align="center" valign="middle" rowspan="1" colspan="1">256 (30.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">214 (28.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.424</td><td align="center" valign="middle" rowspan="1" colspan="1">1.141 (0.919–1.418)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.233</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">576 (69.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">549 (72.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" rowspan="1" colspan="1">23 (2.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">21 (2.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.001</td><td align="center" valign="middle" rowspan="1" colspan="1">1.008(0.553–1.838)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.980</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GC + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">809 (97.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">742 (97.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2075745</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">113 (14.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">106 (14.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.080</td><td align="center" valign="middle" rowspan="1" colspan="1">0.956 (0.703–1.302)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.777</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TA</td><td align="center" valign="middle" rowspan="1" colspan="1">340 (42.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">318 (42.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.026</td><td align="center" valign="middle" rowspan="1" colspan="1">0.982 (0.791–1.219)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.871</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">350 (43.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">323 (43.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">T</td><td align="center" valign="middle" rowspan="1" colspan="1">566 (35.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">530 (35.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.018</td><td align="center" valign="middle" rowspan="1" colspan="1">0.990 (0.854–1.147)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.892</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1040 (64.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">964 (64.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT + TA</td><td align="center" valign="middle" rowspan="1" colspan="1">453 (56.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">424 (56.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.056</td><td align="center" valign="middle" rowspan="1" colspan="1">0.976 (0.797–1.194)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.812</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">350 (43.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">323 (43.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">113 (14.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">106 (14.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.058</td><td align="center" valign="middle" rowspan="1" colspan="1">0.965(0.722–1.289)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.809</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TA + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">690 (85.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">641 (85.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2285991</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">678 (86.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">612 (86.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.773</td><td align="center" valign="middle" rowspan="1" colspan="1">0.611 (0.203–1.834)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.379</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA</td><td align="center" valign="middle" rowspan="1" colspan="1">100 (12.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">90 (12.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.719</td><td align="center" valign="middle" rowspan="1" colspan="1">0.613 (0.198–1.900)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.396</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 (1.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5 (0.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1456 (92.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1314 (92.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.199</td><td align="center" valign="middle" rowspan="1" colspan="1">0.939 (0.712–1.238)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.656</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">118 (7.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">100 (7.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA + AA</td><td align="center" valign="middle" rowspan="1" colspan="1">109 (13.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">95 (13.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.058</td><td align="center" valign="middle" rowspan="1" colspan="1">1.037 (0.770–1.397)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.809</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">678 (86.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">612 (86.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">9 (1.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">5 (0.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.772</td><td align="center" valign="middle" rowspan="1" colspan="1">1.637 (0.545–4.914)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.380</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GA + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">778 (98.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">702 (99.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2632516</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">270 (32.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">229 (29.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.151</td><td align="center" valign="middle" rowspan="1" colspan="1">1.161 (0.884–1.527)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.283</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GC</td><td align="center" valign="middle" rowspan="1" colspan="1">379 (45.8))</td><td align="center" valign="middle" rowspan="1" colspan="1">373 (47.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.015</td><td align="center" valign="middle" rowspan="1" colspan="1">1.016 (0.789–1.309)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.901</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">179 (21.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">178 (22.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">919 (55.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">831 (53.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.604</td><td align="center" valign="middle" rowspan="1" colspan="1">1.094 (0.952–1.257)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.205</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">737 (44.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">729 (46.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG + GC</td><td align="center" valign="middle" rowspan="1" colspan="1">649 (78.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">602 (77.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.329</td><td align="center" valign="middle" rowspan="1" colspan="1">1.072 (0.846–1.357)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.566</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">179 (21.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">178 (22.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">270 (32.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">229 (29.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.632</td><td align="center" valign="middle" rowspan="1" colspan="1">1.149 (0.928–1.422)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.201</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GC + CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">558 (67.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">551 (70.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2877877</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">50 (6.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">53 (7.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.270</td><td align="center" valign="middle" rowspan="1" colspan="1">0.790 (0.524–1.190)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.260</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA</td><td align="center" valign="middle" rowspan="1" colspan="1">272 (33.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">248 (34.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.561</td><td align="center" valign="middle" rowspan="1" colspan="1">0.921 (0.741–1.143)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.454</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">500 (60.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">422 (58.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">372 (22.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">354 (24.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.470</td><td align="center" valign="middle" rowspan="1" colspan="1">0.902 (0.764–1.066)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.225</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1272 (77.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1092 (75.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG + GA</td><td align="center" valign="middle" rowspan="1" colspan="1">322 (39.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">301 (41.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.070</td><td align="center" valign="middle" rowspan="1" colspan="1">0.898 (0.731–1.101)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.301</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">500 (60.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">422 (58.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">50 (6.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">53 (7.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.006</td><td align="center" valign="middle" rowspan="1" colspan="1">0.814 (0.544–1.217)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.316</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GA + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">772 (93.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">670 (92.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs13414</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">368 (51.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">316 (46.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.149</td><td align="center" valign="middle" rowspan="1" colspan="1">1.076 (0.741–1.563)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.700</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG</td><td align="center" valign="middle" rowspan="1" colspan="1">283 (39.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">295 (43.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.403</td><td align="center" valign="middle" rowspan="1" colspan="1">0.885 (0.606–1.292)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.526</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">70 (9.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">65 (9.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">1019 (70.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">927 (68.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.456</td><td align="center" valign="middle" rowspan="1" colspan="1">1.104 (0.940–1.298)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.228</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">G</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">423 (29.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">425 (31.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG + GG</td><td align="center" valign="middle" rowspan="1" colspan="1">353 (49.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">360 (53.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2.551</td><td align="center" valign="middle" rowspan="1" colspan="1">0.841 (0.681–1.040)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.110</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">368 (51.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">316 (46.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">70 (9.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">65 (9.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.008</td><td align="center" valign="middle" rowspan="1" colspan="1">1.016 (0.710–1.455)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.930</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AG + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">651 (90.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">611 (90.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs4372750</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">168 (23.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">156 (23.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.184</td><td align="center" valign="middle" rowspan="1" colspan="1">1.070 (0.786–1.456)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.668</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AC</td><td align="center" valign="middle" rowspan="1" colspan="1">378 (52.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">352 (51.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.370</td><td align="center" valign="middle" rowspan="1" colspan="1">1.084 (0.836–1.405)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.543</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (23.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (25.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">714 (49.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">664 (49.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.222</td><td align="center" valign="middle" rowspan="1" colspan="1">1.036 (0.893–1.202)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.637</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">718 (50.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">692 (51.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA + AC</td><td align="center" valign="middle" rowspan="1" colspan="1">546 (76.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">508 (74.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.318</td><td align="center" valign="middle" rowspan="1" colspan="1">1.074 (0.839–1.374)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.573</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (23.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (25.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">168 (23.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">156 (23.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.006</td><td align="center" valign="middle" rowspan="1" colspan="1">1.007 (0.999–1.015)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.937</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AC+CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">548 (76.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">522 (77.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs12601867</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" rowspan="1" colspan="1">165 (22.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">166 (24.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.953</td><td align="center" valign="middle" rowspan="1" colspan="1">0.860 (0.634–1.165)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.329</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CG</td><td align="center" valign="middle" rowspan="1" colspan="1">381 (52.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">361 (52.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.274</td><td align="center" valign="middle" rowspan="1" colspan="1">0.934 (0.723–1.206)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.601</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">185 (25.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">165 (23.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">C</td><td align="center" valign="middle" rowspan="1" colspan="1">711 (48.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">693 (50.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.590</td><td align="center" valign="middle" rowspan="1" colspan="1">0.944 (0.815–1.094)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.442</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">G</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">751 (51.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">691 (49.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CG + GG</td><td align="center" valign="middle" rowspan="1" colspan="1">566 (77.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">526 (76.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.681</td><td align="center" valign="middle" rowspan="1" colspan="1">1.111 (0.866–1.425)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.409</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">165 (22.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">166 (24.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">185 (25.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">165 (23.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.571</td><td align="center" valign="middle" rowspan="1" colspan="1">1.098 (0.861–1.400)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.450</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CG + CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">546 (74.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">527 (76.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs16847206</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">338 (46.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">296 (43.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.358</td><td align="center" valign="middle" rowspan="1" colspan="1">1.247 (0.860–1.808)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.244</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AT</td><td align="center" valign="middle" rowspan="1" colspan="1">325 (44.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">308 (45.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.679</td><td align="center" valign="middle" rowspan="1" colspan="1">1.169 (0.806–1.694)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.410</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">64 (8.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">73 (10.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">1001 (68.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">900 (66.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.808</td><td align="center" valign="middle" rowspan="1" colspan="1">1.115 (0.952–1.306)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.179</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">T</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">453 (31.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">454 (33.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AT + TT</td><td align="center" valign="middle" rowspan="1" colspan="1">389 (53.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">381 (56.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.735</td><td align="center" valign="middle" rowspan="1" colspan="1">0.911 (0.737–1.127)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.391</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">338 (46.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">296 (43.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">64 (8.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">73 (10.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.086</td><td align="center" valign="middle" rowspan="1" colspan="1">0.828 (0.581–1.180)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.297</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AT + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">663 (91.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">604 (89.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6692753</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">339 (46.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">287 (42.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.624</td><td align="center" valign="middle" rowspan="1" colspan="1">1.272 (0.878–1.843)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.203</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT</td><td align="center" valign="middle" rowspan="1" colspan="1">323 (44.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">323 (47.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.241</td><td align="center" valign="middle" rowspan="1" colspan="1">1.097 (0.758–1.587)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.623</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">65 (8.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">73 (10.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1001 (68.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">897 (65.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">3.231</td><td align="center" valign="middle" rowspan="1" colspan="1">1.155 (0.987–1.352)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.072</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">T</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">453 (31.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">469 (34.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT + TT</td><td align="center" valign="middle" rowspan="1" colspan="1">388 (53.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">396 (58.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">2.315</td><td align="center" valign="middle" rowspan="1" colspan="1">0.848 (0.686–1.049)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.128</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">339 (46.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">287 (42.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">65 (8.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">73 (10.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.842</td><td align="center" valign="middle" rowspan="1" colspan="1">0.848 (0.596–1.206)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.359</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GT + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">662 (91.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">610 (89.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2680700</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">412 (57.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">376 (55.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.773</td><td align="center" valign="middle" rowspan="1" colspan="1">0.755 (0.499–1.142)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.183</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT</td><td align="center" valign="middle" rowspan="1" colspan="1">243 (33.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">263 (38.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">4.477</td><td align="center" valign="middle" rowspan="1" colspan="1">0.630 (0.411–0.967)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.034</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">64 (8.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">43 (6.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1067 (74.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1015 (74.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.017</td><td align="center" valign="middle" rowspan="1" colspan="1">0.989 (0.835–1.172)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.897</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">T</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">371 (25.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">349 (25.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT + TT</td><td align="center" valign="middle" rowspan="1" colspan="1">307 (42.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">306 (44.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.857</td><td align="center" valign="middle" rowspan="1" colspan="1">0.904 (0.731–1.119)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.355</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">412 (57.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">376 (55.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">64 (8.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">43 (6.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2.896</td><td align="center" valign="middle" rowspan="1" colspan="1">1.421 (0.948–2.131)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.089</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GT+GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">655 (91.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">639 (93.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs8071916</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">175 (24.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">162 (23.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.016</td><td align="center" valign="middle" rowspan="1" colspan="1">1.020 (0.751–1.384)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.900</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG</td><td align="center" valign="middle" rowspan="1" colspan="1">378 (52.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">366 (53.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.015</td><td align="center" valign="middle" rowspan="1" colspan="1">0.984 (0.758–1.277)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.904</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">174 (23.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">163 (23.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">728 (50.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">690 (49.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.006</td><td align="center" valign="middle" rowspan="1" colspan="1">1.006 (0.868–1.165)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.940</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">G</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">726 (49.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">692 (50.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG + GG</td><td align="center" valign="middle" rowspan="1" colspan="1">552 (75.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">529 (76.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.059</td><td align="center" valign="middle" rowspan="1" colspan="1">0.970 (0.758–1.241)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.808</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">175 (24.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">162 (23.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">174 (23.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">163 (23.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.002</td><td align="center" valign="middle" rowspan="1" colspan="1">1.005 (0.785–1.287)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.969</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AG + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">553 (76.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">528 (76.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn><p>RA, rheumatoid arthritis; HC, control; OR, odds ratio; CI, confidence interval; SNPs, single nucleotide polymorphisms; <italic>p</italic><sub>adjust</sub>, <italic>p</italic> value adjusted for gender and age.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t006" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t006_Table 6</object-id><label>Table 6</label><caption><p>Correlations of lncRNAs expression levels with genotypes of gene single nucleotide polymorphisms in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">SNPs</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">GAS5</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">linc0597</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">H19</th></tr><tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2067051</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.030</td><td align="center" valign="middle" rowspan="1" colspan="1">0.823</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.076</td><td align="center" valign="middle" rowspan="1" colspan="1">0.569</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.011</td><td align="center" valign="middle" rowspan="1" colspan="1">0.935</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2075745</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.025</td><td align="center" valign="middle" rowspan="1" colspan="1">0.850</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.055</td><td align="center" valign="middle" rowspan="1" colspan="1">0.681</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.107</td><td align="center" valign="middle" rowspan="1" colspan="1">0.420</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2877877</td><td align="center" valign="middle" rowspan="1" colspan="1">0.085</td><td align="center" valign="middle" rowspan="1" colspan="1">0.523</td><td align="center" valign="middle" rowspan="1" colspan="1">0.088</td><td align="center" valign="middle" rowspan="1" colspan="1">0.509</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.031</td><td align="center" valign="middle" rowspan="1" colspan="1">0.815</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2070107</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.077</td><td align="center" valign="middle" rowspan="1" colspan="1">0.560</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.142</td><td align="center" valign="middle" rowspan="1" colspan="1">0.285</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.051</td><td align="center" valign="middle" rowspan="1" colspan="1">0.703</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2632516</td><td align="center" valign="middle" rowspan="1" colspan="1">0.096</td><td align="center" valign="middle" rowspan="1" colspan="1">0.470</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.094</td><td align="center" valign="middle" rowspan="1" colspan="1">0.478</td><td align="center" valign="middle" rowspan="1" colspan="1">0.031</td><td align="center" valign="middle" rowspan="1" colspan="1">0.816</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6790</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.941</td><td align="center" valign="middle" rowspan="1" colspan="1">0.029</td><td align="center" valign="middle" rowspan="1" colspan="1">0.828</td><td align="center" valign="middle" rowspan="1" colspan="1">0.068</td><td align="center" valign="middle" rowspan="1" colspan="1">0.611</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2285991</td><td align="center" valign="middle" rowspan="1" colspan="1">0.103</td><td align="center" valign="middle" rowspan="1" colspan="1">0.438</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.079</td><td align="center" valign="middle" rowspan="1" colspan="1">0.551</td><td align="center" valign="middle" rowspan="1" colspan="1">0.055</td><td align="center" valign="middle" rowspan="1" colspan="1">0.677</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs13414</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.149</td><td align="center" valign="middle" rowspan="1" colspan="1">0.360</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.041</td><td align="center" valign="middle" rowspan="1" colspan="1">0.803</td><td align="center" valign="middle" rowspan="1" colspan="1">0.014</td><td align="center" valign="middle" rowspan="1" colspan="1">0.930</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs4372750</td><td align="center" valign="middle" rowspan="1" colspan="1">0.344</td><td align="center" valign="middle" rowspan="1" colspan="1">0.030</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.950</td><td align="center" valign="middle" rowspan="1" colspan="1">0.202</td><td align="center" valign="middle" rowspan="1" colspan="1">0.211</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs12601867</td><td align="center" valign="middle" rowspan="1" colspan="1">0.216</td><td align="center" valign="middle" rowspan="1" colspan="1">0.180</td><td align="center" valign="middle" rowspan="1" colspan="1">0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.950</td><td align="center" valign="middle" rowspan="1" colspan="1">0.244</td><td align="center" valign="middle" rowspan="1" colspan="1">0.129</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs16847206</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.135</td><td align="center" valign="middle" rowspan="1" colspan="1">0.414</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.090</td><td align="center" valign="middle" rowspan="1" colspan="1">0.588</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.136</td><td align="center" valign="middle" rowspan="1" colspan="1">0.408</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6692753</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.143</td><td align="center" valign="middle" rowspan="1" colspan="1">0.378</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.100</td><td align="center" valign="middle" rowspan="1" colspan="1">0.538</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.145</td><td align="center" valign="middle" rowspan="1" colspan="1">0.373</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2680700</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.149</td><td align="center" valign="middle" rowspan="1" colspan="1">0.358</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.135</td><td align="center" valign="middle" rowspan="1" colspan="1">0.406</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.013</td><td align="center" valign="middle" rowspan="1" colspan="1">0.939</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs8071916</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.279</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.081</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.027</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.870</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.250</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.120</td></tr></tbody></table><table-wrap-foot><fn><p>SNPs, gene single nucleotide polymorphisms.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000430 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000430 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |