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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long non-coding RNA H19 regulates cell growth and metastasis via miR-138 in breast cancer</title><author><name sortKey="Si, Haiyan" sort="Si, Haiyan" uniqKey="Si H" first="Haiyan" last="Si">Haiyan Si</name><affiliation><nlm:aff id="au1"><institution>Department of Breast and Thyroid Surgery, First People’s Hospital of Jiaozuo City</institution><addr-line>Jiaozuo 454000, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ping" sort="Chen, Ping" uniqKey="Chen P" first="Ping" last="Chen">Ping Chen</name><affiliation><nlm:aff id="au2"><institution>Department of Pharmacy, Affiliated Hospital of Shandong Medical College</institution><addr-line>Jinan 276000, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Hongtao" sort="Li, Hongtao" uniqKey="Li H" first="Hongtao" last="Li">Hongtao Li</name><affiliation><nlm:aff id="au1"><institution>Department of Breast and Thyroid Surgery, First People’s Hospital of Jiaozuo City</institution><addr-line>Jiaozuo 454000, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xiang" sort="Wang, Xiang" uniqKey="Wang X" first="Xiang" last="Wang">Xiang Wang</name><affiliation><nlm:aff id="au3"><institution>Physical Examination Centre, The Third Affiliated Hospital of Chongqing Medical University</institution><addr-line>Chongqing 401120, China</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31217890</idno><idno type="pmc">6556666</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556666</idno><idno type="RBID">PMC:6556666</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000353</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000353</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long non-coding RNA H19 regulates cell growth and metastasis via miR-138 in breast cancer</title><author><name sortKey="Si, Haiyan" sort="Si, Haiyan" uniqKey="Si H" first="Haiyan" last="Si">Haiyan Si</name><affiliation><nlm:aff id="au1"><institution>Department of Breast and Thyroid Surgery, First People’s Hospital of Jiaozuo City</institution><addr-line>Jiaozuo 454000, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ping" sort="Chen, Ping" uniqKey="Chen P" first="Ping" last="Chen">Ping Chen</name><affiliation><nlm:aff id="au2"><institution>Department of Pharmacy, Affiliated Hospital of Shandong Medical College</institution><addr-line>Jinan 276000, Shandong, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Hongtao" sort="Li, Hongtao" uniqKey="Li H" first="Hongtao" last="Li">Hongtao Li</name><affiliation><nlm:aff id="au1"><institution>Department of Breast and Thyroid Surgery, First People’s Hospital of Jiaozuo City</institution><addr-line>Jiaozuo 454000, China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wang, Xiang" sort="Wang, Xiang" uniqKey="Wang X" first="Xiang" last="Wang">Xiang Wang</name><affiliation><nlm:aff id="au3"><institution>Physical Examination Centre, The Third Affiliated Hospital of Chongqing Medical University</institution><addr-line>Chongqing 401120, China</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Translational Research</title><idno type="eISSN">1943-8141</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Breast cancer is one of the most common cancers among women. Long non-coding RNAs (lncRNAs) are involved in the initiation and development of breast cancer and lncRNA H19 is a potential oncogenic factor; however, the underlying mechanisms remain unknown. In the present study, the regulatory functions of H19 in breast cancer were investigated. We found that H19 was upregulated in breast cancer tissues and cells and associated with poor prognosis. MiR-138 was downregulated in breast cancer tissues and negatively correlated with the expression of H19 and SOX4. Furthermore, SOX4 was upregulated in breast cancer tissues and positively correlated with H19. Downregulated H19 suppressed the proliferation, invasion and migration of breast cancer cells, but promoted cell cycle arrest and apoptosis. Additionally, miR-138 was identified as a direct target of H19 and SOX4; overexpression of miR-138 inhibited the proliferation, invasion and migration of MDA-MB-231 and MCF-7 cells, but promoted apoptosis, which were abrogated by SOX4 overexpression. Downregulated miR-138 induced cell proliferation, invasion and migration, but inhibited apoptosis of MDA-MB-231 and MCF-7 cells, which were promoted by SOX4 overexpression. In addition, miR-138 overexpression reversed the effects of H19 in breast cancer cells; silencing of H19 inhibited tumor growth and downregulate EMT markers <italic>in vivo</italic>. In summary, H19 was upregulated in breast cancer and associated with poor prognosis. Silencing of H19 inhibited cell proliferation, invasion and migration, but induced cell cycle arrest and apoptosis by regulating miR-138 and SOX4 in breast cancer.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Transl Res</journal-id><journal-id journal-id-type="iso-abbrev">Am J Transl Res</journal-id><journal-id journal-id-type="publisher-id">ajtr</journal-id><journal-title-group><journal-title>American Journal of Translational Research</journal-title></journal-title-group><issn pub-type="epub">1943-8141</issn><publisher><publisher-name>e-Century Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31217890</article-id><article-id pub-id-type="pmc">6556666</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Long non-coding RNA H19 regulates cell growth and metastasis via miR-138 in breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Si</surname><given-names>Haiyan</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ping</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Hongtao</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xiang</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><aff id="au1"><label>1</label><institution>Department of Breast and Thyroid Surgery, First People’s Hospital of Jiaozuo City</institution><addr-line>Jiaozuo 454000, China</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Pharmacy, Affiliated Hospital of Shandong Medical College</institution><addr-line>Jinan 276000, Shandong, China</addr-line></aff><aff id="au3"><label>3</label><institution>Physical Examination Centre, The Third Affiliated Hospital of Chongqing Medical University</institution><addr-line>Chongqing 401120, China</addr-line></aff></contrib-group><author-notes><corresp><bold>Address correspondence to:</bold> Dr. Xiang Wang, Physical Examination Centre, The Third Affiliated Hospital of Chongqing Medical University, No 1, Shuanghu Branch Road, Yubei District, Chongqing 401120, China. E-mail: <email>wx307@hospital.cqmu.edu.cn</email></corresp></author-notes><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>15</day><month>5</month><year>2019</year></pub-date><volume>11</volume><issue>5</issue><fpage>3213</fpage><lpage>3225</lpage><history><date date-type="received"><day>24</day><month>1</month><year>2019</year></date><date date-type="accepted"><day>13</day><month>3</month><year>2019</year></date></history><permissions><copyright-statement>AJTR Copyright © 2019</copyright-statement><copyright-year>2019</copyright-year></permissions><abstract><p>Breast cancer is one of the most common cancers among women. Long non-coding RNAs (lncRNAs) are involved in the initiation and development of breast cancer and lncRNA H19 is a potential oncogenic factor; however, the underlying mechanisms remain unknown. In the present study, the regulatory functions of H19 in breast cancer were investigated. We found that H19 was upregulated in breast cancer tissues and cells and associated with poor prognosis. MiR-138 was downregulated in breast cancer tissues and negatively correlated with the expression of H19 and SOX4. Furthermore, SOX4 was upregulated in breast cancer tissues and positively correlated with H19. Downregulated H19 suppressed the proliferation, invasion and migration of breast cancer cells, but promoted cell cycle arrest and apoptosis. Additionally, miR-138 was identified as a direct target of H19 and SOX4; overexpression of miR-138 inhibited the proliferation, invasion and migration of MDA-MB-231 and MCF-7 cells, but promoted apoptosis, which were abrogated by SOX4 overexpression. Downregulated miR-138 induced cell proliferation, invasion and migration, but inhibited apoptosis of MDA-MB-231 and MCF-7 cells, which were promoted by SOX4 overexpression. In addition, miR-138 overexpression reversed the effects of H19 in breast cancer cells; silencing of H19 inhibited tumor growth and downregulate EMT markers <italic>in vivo</italic>. In summary, H19 was upregulated in breast cancer and associated with poor prognosis. Silencing of H19 inhibited cell proliferation, invasion and migration, but induced cell cycle arrest and apoptosis by regulating miR-138 and SOX4 in breast cancer.</p></abstract><kwd-group><kwd>Breast cancer</kwd><kwd>long non-coding RNA H19</kwd><kwd>microRNA-181</kwd><kwd>SOX4</kwd><kwd>proliferation</kwd><kwd>invasion</kwd><kwd>migration</kwd><kwd>cell cycle</kwd><kwd>apoptosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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