Bubbles in the Box: Recurrent Pneumothorax From Bronchopleural Fistula in Rheumatoid Arthritis
Identifieur interne : 000306 ( Pmc/Corpus ); précédent : 000305; suivant : 000307Bubbles in the Box: Recurrent Pneumothorax From Bronchopleural Fistula in Rheumatoid Arthritis
Auteurs : Ahmed Taha ; Randa Hazam ; Jim Tseng ; Lusine Nahapetyan ; Masoud Alzeerah ; Asm IslamSource :
- Journal of Investigative Medicine High Impact Case Reports [ 2324-7096 ] ; 2019.
Abstract
When considering rheumatoid arthritis (RA)-associated pulmonary diseases, interstitial lung disease and pleural disease are the most common RA-associated pulmonary manifestations while spontaneous pneumothorax and bronchopleural fistula (BPF) are among the extremely rare ones. To the best of our knowledge, all the previous reports of RA-associated BPFs were attributed to peripherally located pulmonary nodules that necrotized, burst into the pleural cavity, and eventually lead to the fistula formation. However, we hereby present the first case of BPF in an RA patient that formed in the absence of any underlying rheumatic pulmonary nodules. Additionally, our patient was on chronic methotrexate therapy, and there are no data in the literature that suggest methotrexate-induced parenchymal lung disease can predispose to BPF formation. Our report is the first to introduce a probe to further investigate this association.
Url:
DOI: 10.1177/2324709619860555
PubMed: 31271042
PubMed Central: 6611010
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bubbles in the Box: Recurrent Pneumothorax From Bronchopleural Fistula in Rheumatoid Arthritis</title><author><name sortKey="Taha, Ahmed" sort="Taha, Ahmed" uniqKey="Taha A" first="Ahmed" last="Taha">Ahmed Taha</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Hazam, Randa" sort="Hazam, Randa" uniqKey="Hazam R" first="Randa" last="Hazam">Randa Hazam</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Jim" sort="Tseng, Jim" uniqKey="Tseng J" first="Jim" last="Tseng">Jim Tseng</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Nahapetyan, Lusine" sort="Nahapetyan, Lusine" uniqKey="Nahapetyan L" first="Lusine" last="Nahapetyan">Lusine Nahapetyan</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Alzeerah, Masoud" sort="Alzeerah, Masoud" uniqKey="Alzeerah M" first="Masoud" last="Alzeerah">Masoud Alzeerah</name><affiliation><nlm:aff id="aff2-2324709619860555">Northwest Texas Hospital System, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Islam, Asm" sort="Islam, Asm" uniqKey="Islam A" first="Asm" last="Islam">Asm Islam</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31271042</idno><idno type="pmc">6611010</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611010</idno><idno type="RBID">PMC:6611010</idno><idno type="doi">10.1177/2324709619860555</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000306</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bubbles in the Box: Recurrent Pneumothorax From Bronchopleural Fistula in Rheumatoid Arthritis</title><author><name sortKey="Taha, Ahmed" sort="Taha, Ahmed" uniqKey="Taha A" first="Ahmed" last="Taha">Ahmed Taha</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Hazam, Randa" sort="Hazam, Randa" uniqKey="Hazam R" first="Randa" last="Hazam">Randa Hazam</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Tseng, Jim" sort="Tseng, Jim" uniqKey="Tseng J" first="Jim" last="Tseng">Jim Tseng</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Nahapetyan, Lusine" sort="Nahapetyan, Lusine" uniqKey="Nahapetyan L" first="Lusine" last="Nahapetyan">Lusine Nahapetyan</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Alzeerah, Masoud" sort="Alzeerah, Masoud" uniqKey="Alzeerah M" first="Masoud" last="Alzeerah">Masoud Alzeerah</name><affiliation><nlm:aff id="aff2-2324709619860555">Northwest Texas Hospital System, Amarillo, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Islam, Asm" sort="Islam, Asm" uniqKey="Islam A" first="Asm" last="Islam">Asm Islam</name><affiliation><nlm:aff id="aff1-2324709619860555">Texas Tech University Health Sciences Center, Amarillo, TX, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Investigative Medicine High Impact Case Reports</title><idno type="eISSN">2324-7096</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>When considering rheumatoid arthritis (RA)-associated pulmonary diseases, interstitial lung disease and pleural disease are the most common RA-associated pulmonary manifestations while spontaneous pneumothorax and bronchopleural fistula (BPF) are among the extremely rare ones. To the best of our knowledge, all the previous reports of RA-associated BPFs were attributed to peripherally located pulmonary nodules that necrotized, burst into the pleural cavity, and eventually lead to the fistula formation. However, we hereby present the first case of BPF in an RA patient that formed in the absence of any underlying rheumatic pulmonary nodules. Additionally, our patient was on chronic methotrexate therapy, and there are no data in the literature that suggest methotrexate-induced parenchymal lung disease can predispose to BPF formation. Our report is the first to introduce a probe to further investigate this association.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Salik, I" uniqKey="Salik I">I Salik</name></author><author><name sortKey="Abramowicz, Ae" uniqKey="Abramowicz A">AE Abramowicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adelman, Hm" uniqKey="Adelman H">HM Adelman</name></author><author><name sortKey="Dupont, El" uniqKey="Dupont E">EL Dupont</name></author><author><name sortKey="Flannery, Mt" uniqKey="Flannery M">MT Flannery</name></author><author><name sortKey="Wallach, Pm" uniqKey="Wallach P">PM Wallach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joseph, J" uniqKey="Joseph J">J Joseph</name></author><author><name sortKey="Sahn, Sa" uniqKey="Sahn S">SA Sahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lois, M" uniqKey="Lois M">M Lois</name></author><author><name sortKey="Noppen, M" uniqKey="Noppen M">M Noppen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rueth, N" uniqKey="Rueth N">N Rueth</name></author><author><name sortKey="Andrade, N" uniqKey="Andrade N">N Andrade</name></author><author><name sortKey="Groth, S" uniqKey="Groth S">S Groth</name></author><author><name sortKey="D Unha, J" uniqKey="D Unha J">J D’Cunha</name></author><author><name sortKey="Maddaus, M" uniqKey="Maddaus M">M Maddaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helmers, R" uniqKey="Helmers R">R Helmers</name></author><author><name sortKey="Galvin, J" uniqKey="Galvin J">J Galvin</name></author><author><name sortKey="Hunninghake, Gw" uniqKey="Hunninghake G">GW Hunninghake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="N Abou, D" uniqKey="N Abou D">D N’Gabou</name></author><author><name sortKey="Magdeleinat, P" uniqKey="Magdeleinat P">P Magdeleinat</name></author><author><name sortKey="Weber, N" uniqKey="Weber N">N Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, Te" uniqKey="Jacobs T">TE Jacobs</name></author><author><name sortKey="Hollingsworth, Hm" uniqKey="Hollingsworth H">HM Hollingsworth</name></author><author><name sortKey="Nash, G" uniqKey="Nash G">G Nash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roubille, C" uniqKey="Roubille C">C Roubille</name></author><author><name sortKey="Haraoui, B" uniqKey="Haraoui B">B Haraoui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camus, P" uniqKey="Camus P">P Camus</name></author><author><name sortKey="Fanton, A" uniqKey="Fanton A">A Fanton</name></author><author><name sortKey="Bonniaud, P" uniqKey="Bonniaud P">P Bonniaud</name></author><author><name sortKey="Camus, C" uniqKey="Camus C">C Camus</name></author><author><name sortKey="Foucher, P" uniqKey="Foucher P">P Foucher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Ja" uniqKey="Singh J">JA Singh</name></author><author><name sortKey="Cameron, C" uniqKey="Cameron C">C Cameron</name></author><author><name sortKey="Noorbaloochi, S" uniqKey="Noorbaloochi S">S Noorbaloochi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name></author><author><name sortKey="Ahadieh, S" uniqKey="Ahadieh S">S Ahadieh</name></author><author><name sortKey="French, J" uniqKey="French J">J French</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katsuyama, T" uniqKey="Katsuyama T">T Katsuyama</name></author><author><name sortKey="Saito, K" uniqKey="Saito K">K Saito</name></author><author><name sortKey="Kubo, S" uniqKey="Kubo S">S Kubo</name></author><author><name sortKey="Nawata, M" uniqKey="Nawata M">M Nawata</name></author><author><name sortKey="Tanaka, T" uniqKey="Tanaka T">T Tanaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurni, Ch" uniqKey="Hurni C">Ch Hurni</name></author><author><name sortKey="Rauch, A" uniqKey="Rauch A">A Rauch</name></author><author><name sortKey="Trost, N" uniqKey="Trost N">N Trost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alarcon, Gs" uniqKey="Alarcon G">GS Alarcon</name></author><author><name sortKey="Kremer, Jm" uniqKey="Kremer J">JM Kremer</name></author><author><name sortKey="Macaluso, M" uniqKey="Macaluso M">M Macaluso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bedrossian, Cw" uniqKey="Bedrossian C">CW Bedrossian</name></author><author><name sortKey="Miller, Wc" uniqKey="Miller W">WC Miller</name></author><author><name sortKey="Luna, Ma" uniqKey="Luna M">MA Luna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, Jad" uniqKey="Cooper J">JAD Cooper</name></author><author><name sortKey="White, Da" uniqKey="White D">DA White</name></author><author><name sortKey="Matthay, Ra" uniqKey="Matthay R">RA Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohbayashi, M1" uniqKey="Ohbayashi M">M1 Ohbayashi</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Yashiro, Y" uniqKey="Yashiro Y">Y Yashiro</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Investig Med High Impact Case Rep</journal-id><journal-id journal-id-type="iso-abbrev">J Investig Med High Impact Case Rep</journal-id><journal-id journal-id-type="publisher-id">HIC</journal-id><journal-id journal-id-type="hwp">sphic</journal-id><journal-title-group><journal-title>Journal of Investigative Medicine High Impact Case Reports</journal-title></journal-title-group><issn pub-type="epub">2324-7096</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage CA: Los Angeles, CA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31271042</article-id><article-id pub-id-type="pmc">6611010</article-id><article-id pub-id-type="doi">10.1177/2324709619860555</article-id><article-id pub-id-type="publisher-id">10.1177_2324709619860555</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Bubbles in the Box: Recurrent Pneumothorax From Bronchopleural Fistula in Rheumatoid Arthritis</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-8243-2936</contrib-id><name><surname>Taha</surname><given-names>Ahmed</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-2324709619860555">1</xref><xref ref-type="corresp" rid="corresp1-2324709619860555"></xref></contrib><contrib contrib-type="author"><name><surname>Hazam</surname><given-names>Randa</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-2324709619860555">1</xref></contrib><contrib contrib-type="author"><name><surname>Tseng</surname><given-names>Jim</given-names></name><xref ref-type="aff" rid="aff1-2324709619860555">1</xref></contrib><contrib contrib-type="author"><name><surname>Nahapetyan</surname><given-names>Lusine</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-2324709619860555">1</xref></contrib><contrib contrib-type="author"><name><surname>Alzeerah</surname><given-names>Masoud</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2-2324709619860555">2</xref></contrib><contrib contrib-type="author"><name><surname>Islam</surname><given-names>Asm</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-2324709619860555">1</xref></contrib></contrib-group><aff id="aff1-2324709619860555"><label>1</label>Texas Tech University Health Sciences Center, Amarillo, TX, USA</aff><aff id="aff2-2324709619860555"><label>2</label>Northwest Texas Hospital System, Amarillo, TX, USA</aff><author-notes><corresp id="corresp1-2324709619860555">Ahmed Taha, MD, Department of Internal Medicine, Texas Tech University Health Sciences Center, 1400 Coulter Street, Suite 2700, Amarillo, TX 79106, USA. Email: <email>aaataha1@gmail.com</email></corresp></author-notes><pub-date pub-type="epub"><day>04</day><month>7</month><year>2019</year></pub-date><pub-date pub-type="collection"><season>Jan-Dec</season><year>2019</year></pub-date><volume>7</volume><elocation-id>2324709619860555</elocation-id><history><date date-type="received"><day>8</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>6</day><month>6</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 American Federation for Medical Research</copyright-statement><copyright-year>2019</copyright-year><copyright-holder content-type="society">American Federation for Medical Research</copyright-holder><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This article is distributed under the terms of the Creative Commons Attribution 4.0 License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by/4.0/">http://www.creativecommons.org/licenses/by/4.0/</ext-link>) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>).</license-p></license></permissions><abstract><p>When considering rheumatoid arthritis (RA)-associated pulmonary diseases, interstitial lung disease and pleural disease are the most common RA-associated pulmonary manifestations while spontaneous pneumothorax and bronchopleural fistula (BPF) are among the extremely rare ones. To the best of our knowledge, all the previous reports of RA-associated BPFs were attributed to peripherally located pulmonary nodules that necrotized, burst into the pleural cavity, and eventually lead to the fistula formation. However, we hereby present the first case of BPF in an RA patient that formed in the absence of any underlying rheumatic pulmonary nodules. Additionally, our patient was on chronic methotrexate therapy, and there are no data in the literature that suggest methotrexate-induced parenchymal lung disease can predispose to BPF formation. Our report is the first to introduce a probe to further investigate this association.</p></abstract><kwd-group><kwd>bronchial fistula</kwd><kwd>rheumatoid arthritis</kwd><kwd>methotrexate</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>January-December 2019</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec sec-type="intro" id="section1-2324709619860555"><title>Introduction</title><p>Although bronchopulmonary fistulas (BPFs) are most commonly seen after lung surgeries, chronic instances are associated with infections and pleural space fibrosis.<sup><xref rid="bibr1-2324709619860555" ref-type="bibr">1</xref></sup> Among the chronic etiologies of BPF, rheumatoid arthritis (RA) has been associated with BPF due to its properties as a multisystem disease that can manifest as recurrent pulmonary infections, interstitial pulmonary fibrosis, and amyloidosis.<sup><xref rid="bibr2-2324709619860555" ref-type="bibr">2</xref></sup> Oftentimes, clinical manifestations, such as pulmonary nodules or structural defects, evolve and lead to empyema, pleural effusion, or pulmonary fibrosis before BPF appears.<sup><xref rid="bibr3-2324709619860555" ref-type="bibr">3</xref></sup> In this case, however, the patient had RA with no pulmonary nodules or structural defects who presented with tension pneumothorax and persistent chest tube air-leak as the primary manifestations. Due to the high morbidity and mortality of undiagnosed BPF,<sup><xref rid="bibr4-2324709619860555" ref-type="bibr">4</xref></sup> we are shedding light on the diagnosis of BPF in RA patients even in the absence of nodules or structural lung disease. Additionally, our patient had been taking methotrexate (MTX), hydroxychloroquine, and prednisone for decades. Hydroxychloroquine has never been reported to mediate pulmonary side effects. Although -MTX is well known for causing parenchymal lung diseases, there are no data in the literature to suggest MTX-induced parenchymal lung disease leads to BPF formation. Our report is the first in literature that introduces a probe to further investigate this association.</p></sec><sec sec-type="cases" id="section2-2324709619860555"><title>Case Report</title><p>We are presenting the case of a 79-year-old Caucasian female with history of rheumatoid arthritis for 40 years and does not have prior history of established structural lung or cardiac disease. She is taking prednisolone, MTX, and hydroxychloroquine for more than 10 years. She presented to the emergency department with 2-day history of worsening dyspnea and palpitations. She was traveling across several states within the United States by a private motor vehicle; however, she did not travel to any high-altitude region. She also did not have any sick contacts. Past medical and family histories were noncontributory. In the emergency department, she was tachypneic, tachycardic, and her oxygen saturations were in the low 80s% in ambient air.</p><p>Physical examination revealed bi-basilar coarse crackles, decreased breath sounds over the right hemi-thorax, and hyper-resonant percussion note. An emergent chest X-ray (CXR) showed massive right-sided tension pneumothorax with collapsed right lung (<xref ref-type="fig" rid="fig1-2324709619860555">Figure 1</xref>). A right-sided 8-French surgical chest tube was inserted. A confirmatory computed tomography (CT) of the chest showed well-positioned chest tube, right pneumothorax, and no pulmonary nodules (<xref ref-type="fig" rid="fig2-2324709619860555">Figure 2</xref>). Initial laboratory workup showed neutrophilic leukocytosis (28 000, 95% neutrophils), arterial blood gas: 7.52/31/58 on 2 L of oxygen. Complete metabolic panel, procalcitonin, and 3 sets of troponin I were all unremarkable. Blood, urine, sputum, and fungal cultures were negative. Transthoracic echocardiogram showed pulmonary hypertension with right ventricular pressure of 50 to 60 mm Hg.</p><fig id="fig1-2324709619860555" orientation="portrait" position="float"><label>Figure 1.</label><caption><p>Chest X-ray showing extensive right side pneumothorax (yellow arrow) complicated by complete right lung collapse (red arrows).</p></caption><graphic xlink:href="10.1177_2324709619860555-fig1"></graphic></fig><fig id="fig2-2324709619860555" orientation="portrait" position="float"><label>Figure 2.</label><caption><p>Noncontrast chest CT scan showing resolving right side pneumothorax (green arrow), mild right subcutaneous emphysema (blue arrows), right-side chest tube (placed for tension pneumothorax; Red arrow). No pulmonary nodules were seen.</p></caption><graphic xlink:href="10.1177_2324709619860555-fig2"></graphic></fig><p>On admission to general medical floor, the patient had good oxygen saturations on 2 L of nasal cannula, and a repeated CXR showed 90% resolution of the pneumothorax. On day 2, the chest tube was removed due to slippage into the subcutaneous layer and the formation of subcutaneous emphysema (<xref ref-type="fig" rid="fig2-2324709619860555">Figure 2</xref>), and pneumothorax was confirmed to be mostly resolved. On the next day, however, a repeat CXR showed re-formation of right sided pneumothorax (occupying 40% of the right hemithorax), for which a 10-French pig tail chest tube was inserted to the right pleural space.</p><p>The chest tube under-water air leak persisted for 5 days following the insertion of the pig tail chest tube and the presence of BPF was suspected; therefore, an explorative thoracotomy was considered. A standard posterolateral thoracotomy and pleuritic exploration showed the presence of BPF at the apical segment of the right lower lobe (<xref ref-type="fig" rid="fig3-2324709619860555">Figure 3</xref>). The BPF was sutured, covered with pleural patch, and anterior and posterior chest tubes were also inserted to the right pleural space intraoperatively. The pathological examination of right lower lobe wedge biopsy revealed fibrosing pleuritis with acute and chronic histiocytic inflammation and subpleural septal fibrosis (<xref ref-type="fig" rid="fig4-2324709619860555">Figure 4</xref>). Postoperatively, the patient continued to improve, with remarkable decrease in air leak and chest tube aspirate and the chest tubes were removed in about day 10 postoperatively.</p><fig id="fig3-2324709619860555" orientation="portrait" position="float"><label>Figure 3.</label><caption><p>Image was taken intra-operatively showing the broncho-pleural fistula (blue arrow).</p></caption><graphic xlink:href="10.1177_2324709619860555-fig3"></graphic></fig><fig id="fig4-2324709619860555" orientation="portrait" position="float"><label>Figure 4.</label><caption><p>Hematoxylin and eosin section of right lower lobe wedge biopsy showing (A) fibrosing pleuritis and subpleural septal fibrosis (black arrows) with (B) acute and chronic histiocytic inflammation (yellow arrows). No pulmonary nodules were seen.</p></caption><graphic xlink:href="10.1177_2324709619860555-fig4"></graphic></fig></sec><sec sec-type="discussion" id="section3-2324709619860555"><title>Discussion</title><p>Approximately 1% of patients with RA develop chronic lung disease, which can lead to complications.<sup><xref rid="bibr5-2324709619860555" ref-type="bibr">5</xref></sup> RA-associated pulmonary manifestations include pleural effusion, pneumothorax, pulmonary infections, pneumonitis, interstitial pulmonary fibrosis, pulmonary nodules, and bronchogenic carcinoma, arteritis with pulmonary hypertension, obliterative bronchiolitis, bronchiectasis, and amyloidosis.<sup><xref rid="bibr3-2324709619860555" ref-type="bibr">3</xref>,<xref rid="bibr6-2324709619860555" ref-type="bibr">6</xref></sup></p><p>On one hand, pleural involvement was described as the most common intrathoracic manifestation of rheumatoid disease, occurring in about 5% of patients.<sup><xref rid="bibr3-2324709619860555" ref-type="bibr">3</xref></sup> Although pleural complications in RA are related to the development of diffuse peripheral pulmonary nodules, the development of pneumothorax has only rarely been described in RA.<sup><xref rid="bibr5-2324709619860555" ref-type="bibr">5</xref>,<xref rid="bibr7-2324709619860555" ref-type="bibr">7</xref></sup> Pleural effusions and pneumothorax can be caused by necrosis of a peripheral nodule leading to cavity formation that—if it bursts to the pleural space—can also lead to the formation of BPF.<sup><xref rid="bibr8-2324709619860555" ref-type="bibr">8</xref></sup></p><p>In our case, the pathological examination of the lung biopsy at the site of the BPF did show fibrosing pleuritis with acute and chronic histiocytic inflammation and subpleural septal fibrosis, which were correlated to long-standing RA and MTX therapy, but no pulmonary nodules were seen. This makes our case the first in the literature to report BPF formation in RA despite the absence of underlying pulmonary nodules and warrants further studies to evaluate for possible unknown pathological processes.</p><p>On the other hand, there have been a variety of drug-induced lung and pleural toxicities reported in virtually all of the disease modifying anti-rheumatic drugs (DMARDs).<sup><xref rid="bibr9-2324709619860555" ref-type="bibr">9</xref></sup> Although the exact pathogenesis of these toxicity is unknown, the risk and type of lung toxicity varies among the different agents used, and they include alveolar, interstitial inflammation, or fibrosis.<sup><xref rid="bibr9-2324709619860555" ref-type="bibr">9</xref>,<xref rid="bibr10-2324709619860555" ref-type="bibr">10</xref></sup> In addition to direct lung toxicity, almost all the DMARDs have immunosuppressive effects that increase the risk of bacterial and opportunistic lung infections.<sup><xref rid="bibr11-2324709619860555" ref-type="bibr">11</xref><xref rid="bibr12-2324709619860555" ref-type="bibr"></xref>-<xref rid="bibr13-2324709619860555" ref-type="bibr">13</xref></sup> Our patient was using MTX, hydroxychloroquine, and prednisone for decades.</p><p>Hydroxychloroquine has never been reported to mediate pulmonary side effects, while prednisone has been reported to rarely cause pulmonary disease through suppressing patients’ immunity and predisposing them to recurrent infections that could promote the formation of pulmonary nodules that eventually form a cavity. In 2008, a case report of a pulmonary nocardiosis was reported in a patient who was on chronic steroid therapy.<sup><xref rid="bibr14-2324709619860555" ref-type="bibr">14</xref></sup> However, MTX, a folic acid antagonist that inhibits cellular reproduction by causing an acute intracellular deficiency of folate coenzymes, is one of the DMARDs that are famous for causing parenchymal pulmonary diseases.<sup><xref rid="bibr9-2324709619860555" ref-type="bibr">9</xref></sup></p><p>Although MTX-induced pneumonitis (MIP) was described as the most common form of MTX-induced lung injury, representing 0.3% to 7.5%,<sup><xref rid="bibr15-2324709619860555" ref-type="bibr">15</xref></sup> other forms of parenchymal lung injury have also been associated with MTX use, such as acute interstitial pneumonia and cryptogenic organizing pneumonia.<sup><xref rid="bibr16-2324709619860555" ref-type="bibr">16</xref></sup> The exact pathogenic mechanism of MTX-induced pulmonary toxicity is still unclear; however, several theories for the pathogenesis of MTX-induced pulmonary toxicity have been described in the literature. MTX leads to hypersensitivity and immunosuppression, predisposing patients to repeated viral or other infections.<sup><xref rid="bibr9-2324709619860555" ref-type="bibr">9</xref>,<xref rid="bibr17-2324709619860555" ref-type="bibr">17</xref></sup> It also induces injury to alveolar epithelial walls, suggesting a direct drug toxicity pathogenesis.<sup><xref rid="bibr18-2324709619860555" ref-type="bibr">18</xref></sup> There are no data in the literature that suggests MTX-induced parenchymal lung disease can predispose to the formation of BPF; thus, our report is the first to introduce a probe to further investigate this association.</p></sec><sec sec-type="conclusions" id="section4-2324709619860555"><title>Conclusions</title><p>Formation of BPF is a rare RA-associated pulmonary disease and is often associated with peripheral pulmonary nodules, which open into the pleural cavity and lead to the fistula formation. However, as demonstrated in our case, BPF in RA patients can form even in the absence of underlying rheumatic pulmonary nodules. Additionally, there are no current data in the literature that suggest MTX-induced parenchymal lung disease can lead to BPF formation; our report is the first to introduce a probe to further investigate this association.</p></sec></body><back><fn-group><fn fn-type="other"><p><bold>Authors’ Note:</bold> The abstract of this article has been presented in the 2018 annual conference of the Society of General Internal Medicine (SGIM) as well as the 2018 Annual Meeting of Chest. The abstract of this case report was published in the <italic>Journal of General Internal Medicine</italic> and <italic>Chest</italic> (Official Journal of the American College of Chest Physicians).</p></fn><fn fn-type="COI-statement"><p><bold>Declaration of Conflicting Interests:</bold> The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.</p></fn><fn fn-type="financial-disclosure"><p><bold>Funding:</bold> The author(s) received no financial support for the research, authorship, and/or publication of this article.</p></fn><fn fn-type="other"><p><bold>Ethical Approval:</bold> Our institution does not require ethical approval for reporting individual cases or case series.</p></fn><fn fn-type="other"><p><bold>Informed Consent:</bold> Verbal informed consent was obtained from the patient(s) for their anonymized information to be published in this article.</p></fn><fn fn-type="other"><p><bold>ORCID iD:</bold> Ahmed Taha <inline-graphic xlink:href="10.1177_2324709619860555-img1.jpg"></inline-graphic><ext-link ext-link-type="uri" xlink:href="https://orcid.org/0000-0002-8243-2936">https://orcid.org/0000-0002-8243-2936</ext-link></p></fn></fn-group><ref-list><title>References</title><ref id="bibr1-2324709619860555"><label>1</label><mixed-citation publication-type="gov"><person-group person-group-type="author"><name><surname>Salik</surname><given-names>I</given-names></name><name><surname>Abramowicz</surname><given-names>AE</given-names></name></person-group><article-title>Bronchopleural fistula</article-title>. <ext-link ext-link-type="uri" xlink:href="https://www.ncbi.nlm.nih.gov/books/NBK534765/">https://www.ncbi.nlm.nih.gov/books/NBK534765/</ext-link>. <comment>Accessed April 28, 2019</comment>.</mixed-citation></ref><ref id="bibr2-2324709619860555"><label>2</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Adelman</surname><given-names>HM</given-names></name><name><surname>Dupont</surname><given-names>EL</given-names></name><name><surname>Flannery</surname><given-names>MT</given-names></name><name><surname>Wallach</surname><given-names>PM</given-names></name></person-group><article-title>Recurrent pneumothorax in a patient with rheumatoid arthritis</article-title>. <source>Am J Med Sci</source>. <year>1994</year>;<volume>308</volume>:<fpage>171</fpage>-<lpage>172</lpage>.<pub-id pub-id-type="pmid">8074134</pub-id></mixed-citation></ref><ref id="bibr3-2324709619860555"><label>3</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Joseph</surname><given-names>J</given-names></name><name><surname>Sahn</surname><given-names>SA</given-names></name></person-group><article-title>Connective tissue diseases and the pleura</article-title>. <source>Chest</source>. <year>1993</year>;<volume>104</volume>:<fpage>262</fpage>-<lpage>270</lpage>.<pub-id pub-id-type="pmid">8325082</pub-id></mixed-citation></ref><ref id="bibr4-2324709619860555"><label>4</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lois</surname><given-names>M</given-names></name><name><surname>Noppen</surname><given-names>M</given-names></name></person-group><article-title>Bronchopleural fistulas: an overview of the problem with special focus on endoscopic management</article-title>. <source>Chest</source>. <year>2005</year>;<volume>128</volume>:<fpage>3955</fpage>-<lpage>3965</lpage>.<pub-id pub-id-type="pmid">16354867</pub-id></mixed-citation></ref><ref id="bibr5-2324709619860555"><label>5</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rueth</surname><given-names>N</given-names></name><name><surname>Andrade</surname><given-names>N</given-names></name><name><surname>Groth</surname><given-names>S</given-names></name><name><surname>D’Cunha</surname><given-names>J</given-names></name><name><surname>Maddaus</surname><given-names>M</given-names></name></person-group><article-title>Pleuropulmonary complications of rheumatoid arthritis: a thoracic surgeon’s challenge</article-title>. <source>Ann Thorac Surg</source>. <year>2009</year>;<volume>88</volume>:<fpage>e20</fpage>-<lpage>e21</lpage>.<pub-id pub-id-type="pmid">19699879</pub-id></mixed-citation></ref><ref id="bibr6-2324709619860555"><label>6</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Helmers</surname><given-names>R</given-names></name><name><surname>Galvin</surname><given-names>J</given-names></name><name><surname>Hunninghake</surname><given-names>GW</given-names></name></person-group><article-title>Pulmonary manifestations associated with rheumatoid arthritis</article-title>. <source>Chest</source>. <year>1991</year>;<volume>100</volume>:<fpage>235</fpage>-<lpage>238</lpage>.<pub-id pub-id-type="pmid">2060351</pub-id></mixed-citation></ref><ref id="bibr7-2324709619860555"><label>7</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>N’Gabou</surname><given-names>D</given-names></name><name><surname>Magdeleinat</surname><given-names>P</given-names></name><name><surname>Weber</surname><given-names>N</given-names></name><etal>et al</etal></person-group><article-title>Pleuropulmonary involvement leading to bilateral pneumothorax in a patient treated for rheumatoid arthritis</article-title>. <source>Rev Mal Respir</source>. <year>2010</year>;<volume>27</volume>:<fpage>1119</fpage>-<lpage>1123</lpage>.<pub-id pub-id-type="pmid">21111289</pub-id></mixed-citation></ref><ref id="bibr8-2324709619860555"><label>8</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jacobs</surname><given-names>TE</given-names></name><name><surname>Hollingsworth</surname><given-names>HM</given-names></name><name><surname>Nash</surname><given-names>G</given-names></name></person-group><article-title>Persistent bilateral effusions and fever in a 48-year-old man</article-title>. <source>Chest</source>. <year>1993</year>;<volume>104</volume>:<fpage>1597</fpage>-<lpage>1599</lpage>.<pub-id pub-id-type="pmid">8222830</pub-id></mixed-citation></ref><ref id="bibr9-2324709619860555"><label>9</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roubille</surname><given-names>C</given-names></name><name><surname>Haraoui</surname><given-names>B</given-names></name></person-group><article-title>Interstitial lung diseases induced or exacerbated by DMARDS and biologic agents in rheumatoid arthritis: a systematic literature review</article-title>. <source>Semin Arthritis Rheum</source>. <year>2014</year>;<volume>43</volume>:<fpage>613</fpage>-<lpage>626</lpage>.<pub-id pub-id-type="pmid">24231065</pub-id></mixed-citation></ref><ref id="bibr10-2324709619860555"><label>10</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Camus</surname><given-names>P</given-names></name><name><surname>Fanton</surname><given-names>A</given-names></name><name><surname>Bonniaud</surname><given-names>P</given-names></name><name><surname>Camus</surname><given-names>C</given-names></name><name><surname>Foucher</surname><given-names>P</given-names></name></person-group><article-title>Interstitial lung disease induced by drugs and radiation</article-title>. <source>Respiration</source>. <year>2004</year>;<volume>71</volume>:<fpage>301</fpage>-<lpage>326</lpage>.<pub-id pub-id-type="pmid">15316202</pub-id></mixed-citation></ref><ref id="bibr11-2324709619860555"><label>11</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Singh</surname><given-names>JA</given-names></name><name><surname>Cameron</surname><given-names>C</given-names></name><name><surname>Noorbaloochi</surname><given-names>S</given-names></name><etal>et al</etal></person-group><article-title>Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis</article-title>. <source>Lancet</source>. <year>2015</year>;<volume>386</volume>:<fpage>258</fpage>-<lpage>265</lpage>.<pub-id pub-id-type="pmid">25975452</pub-id></mixed-citation></ref><ref id="bibr12-2324709619860555"><label>12</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Strand</surname><given-names>V</given-names></name><name><surname>Ahadieh</surname><given-names>S</given-names></name><name><surname>French</surname><given-names>J</given-names></name><etal>et al</etal></person-group><article-title>Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials</article-title>. <source>Arthritis Res Ther</source>. <year>2015</year>;<volume>17</volume>:<fpage>362</fpage>.<pub-id pub-id-type="pmid">26669566</pub-id></mixed-citation></ref><ref id="bibr13-2324709619860555"><label>13</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katsuyama</surname><given-names>T</given-names></name><name><surname>Saito</surname><given-names>K</given-names></name><name><surname>Kubo</surname><given-names>S</given-names></name><name><surname>Nawata</surname><given-names>M</given-names></name><name><surname>Tanaka</surname><given-names>T</given-names></name></person-group><article-title>Prophylaxis for <italic>Pneumocystis pneumonia</italic> in patients with rheumatoid arthritis treated with biologics, based on risk factors found in a retrospective study</article-title>. <source>Arthritis Res Ther</source>. <year>2014</year>;<volume>16</volume>:<fpage>R43</fpage>.<pub-id pub-id-type="pmid">24495443</pub-id></mixed-citation></ref><ref id="bibr14-2324709619860555"><label>14</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hurni</surname><given-names>Ch</given-names></name><name><surname>Rauch</surname><given-names>A</given-names></name><name><surname>Trost</surname><given-names>N</given-names></name><etal>et al</etal></person-group><article-title>Pulmonary nodules in a patient on long-term steroid treatment</article-title>. <source>Praxis (Bern 1994)</source>. <year>2008</year>;<volume>97</volume>:<fpage>849</fpage>-<lpage>852</lpage>.<pub-id pub-id-type="pmid">18754339</pub-id></mixed-citation></ref><ref id="bibr15-2324709619860555"><label>15</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alarcon</surname><given-names>GS</given-names></name><name><surname>Kremer</surname><given-names>JM</given-names></name><name><surname>Macaluso</surname><given-names>M</given-names></name><etal>et al</etal></person-group><article-title>Risk Factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group</article-title>. <source>Ann Intern Med</source>. <year>1997</year>;<volume>127</volume>:<fpage>356</fpage>-<lpage>364</lpage>.<pub-id pub-id-type="pmid">9273826</pub-id></mixed-citation></ref><ref id="bibr16-2324709619860555"><label>16</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bedrossian</surname><given-names>CW</given-names></name><name><surname>Miller</surname><given-names>WC</given-names></name><name><surname>Luna</surname><given-names>MA</given-names></name></person-group><article-title>Methotrexate-induced diffuse interstitial pulmonary fibrosis</article-title>. <source>South Med J</source>. <year>1979</year>;<volume>72</volume>:<fpage>313</fpage>-<lpage>318</lpage>.<pub-id pub-id-type="pmid">424824</pub-id></mixed-citation></ref><ref id="bibr17-2324709619860555"><label>17</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cooper</surname><given-names>JAD</given-names><suffix>Jr</suffix></name><name><surname>White</surname><given-names>DA</given-names></name><name><surname>Matthay</surname><given-names>RA</given-names></name></person-group><article-title>Drug-induced pulmonary disease. Part 1: cytotoxic drugs</article-title>. <source>Am Rev Respir Dis</source>. <year>1986</year>;<fpage>133</fpage>.</mixed-citation></ref><ref id="bibr18-2324709619860555"><label>18</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ohbayashi</surname><given-names>M1</given-names></name><name><surname>Suzuki</surname><given-names>M</given-names></name><name><surname>Yashiro</surname><given-names>Y</given-names></name><etal>et al</etal></person-group><article-title>Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro</article-title>. <source>J Toxicol Sci</source>. <year>2010</year>;<volume>35</volume>:<fpage>653</fpage>-<lpage>661</lpage>.<pub-id pub-id-type="pmid">20930460</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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