Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis
Identifieur interne : 000275 ( Pmc/Corpus ); précédent : 000274; suivant : 000276Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis
Auteurs : Karishma Sharma ; Fredrick Otieno ; Reena ShahSource :
- Case Reports in Medicine [ 1687-9627 ] ; 2020.
Abstract
Kikuchi-Fujimoto disease (KFD) is a rare form of painful lymphadenopathy, usually cervical, which is more common in Southeast Asia and rarely reported from Africa. Symptoms are usually nonspecific (fever, night sweats, etc.), and can mimic more common diseases such as tuberculosis (TB) in endemic areas. We report a case of a 29-year-old black African woman who was admitted with headache, neck pain, fever, and lymphadenopathy. She was found to have aseptic meningitis, eventually attributed to TB based on cervical node biopsy, although further histology suggested KFD. Blood tests for systemic lupus erythematosus (SLE) were negative; she had already been commenced on anti-TB treatment and had responded well and so was continued with this therapy. She was also later diagnosed with Hashimoto's thyroiditis 3 months after her diagnosis of KFD. Five months after stopping TB treatment, she was readmitted with the same symptoms and associated painless lymphadenopathy. Repeat biopsy was morphologically similar to that of 2017, and repeat evaluation confirmed SLE. She has since been managed by a rheumatologist and continues to do well.
Url:
DOI: 10.1155/2020/4385286
PubMed: 31969905
PubMed Central: 6969645
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis</title><author><name sortKey="Sharma, Karishma" sort="Sharma, Karishma" uniqKey="Sharma K" first="Karishma" last="Sharma">Karishma Sharma</name><affiliation><nlm:aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Otieno, Fredrick" sort="Otieno, Fredrick" uniqKey="Otieno F" first="Fredrick" last="Otieno">Fredrick Otieno</name><affiliation><nlm:aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Shah, Reena" sort="Shah, Reena" uniqKey="Shah R" first="Reena" last="Shah">Reena Shah</name><affiliation><nlm:aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31969905</idno><idno type="pmc">6969645</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969645</idno><idno type="RBID">PMC:6969645</idno><idno type="doi">10.1155/2020/4385286</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis</title><author><name sortKey="Sharma, Karishma" sort="Sharma, Karishma" uniqKey="Sharma K" first="Karishma" last="Sharma">Karishma Sharma</name><affiliation><nlm:aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Otieno, Fredrick" sort="Otieno, Fredrick" uniqKey="Otieno F" first="Fredrick" last="Otieno">Fredrick Otieno</name><affiliation><nlm:aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Shah, Reena" sort="Shah, Reena" uniqKey="Shah R" first="Reena" last="Shah">Reena Shah</name><affiliation><nlm:aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</nlm:aff></affiliation></author></analytic><series><title level="j">Case Reports in Medicine</title><idno type="ISSN">1687-9627</idno><idno type="eISSN">1687-9635</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Kikuchi-Fujimoto disease (KFD) is a rare form of painful lymphadenopathy, usually cervical, which is more common in Southeast Asia and rarely reported from Africa. Symptoms are usually nonspecific (fever, night sweats, etc.), and can mimic more common diseases such as tuberculosis (TB) in endemic areas. We report a case of a 29-year-old black African woman who was admitted with headache, neck pain, fever, and lymphadenopathy. She was found to have aseptic meningitis, eventually attributed to TB based on cervical node biopsy, although further histology suggested KFD. Blood tests for systemic lupus erythematosus (SLE) were negative; she had already been commenced on anti-TB treatment and had responded well and so was continued with this therapy. She was also later diagnosed with Hashimoto's thyroiditis 3 months after her diagnosis of KFD. Five months after stopping TB treatment, she was readmitted with the same symptoms and associated painless lymphadenopathy. Repeat biopsy was morphologically similar to that of 2017, and repeat evaluation confirmed SLE. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Med</journal-id><journal-id journal-id-type="iso-abbrev">Case Rep Med</journal-id><journal-id journal-id-type="publisher-id">CRIM</journal-id><journal-title-group><journal-title>Case Reports in Medicine</journal-title></journal-title-group><issn pub-type="ppub">1687-9627</issn><issn pub-type="epub">1687-9635</issn><publisher><publisher-name>Hindawi</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31969905</article-id><article-id pub-id-type="pmc">6969645</article-id><article-id pub-id-type="doi">10.1155/2020/4385286</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0003-0798-0745</contrib-id><name><surname>Sharma</surname><given-names>Karishma</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Otieno</surname><given-names>Fredrick</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0003-1729-5012</contrib-id><name><surname>Shah</surname><given-names>Reena</given-names></name><email>reena.shah@aku.edu</email><xref ref-type="aff" rid="I1"></xref></contrib></contrib-group><aff id="I1">Department of Medicine, Aga Khan University Hospital, Nairobi, Kenya</aff><author-notes><fn fn-type="other"><p>Academic Editor: Jagdish Butany</p></fn></author-notes><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>5</day><month>1</month><year>2020</year></pub-date><volume>2020</volume><elocation-id>4385286</elocation-id><history><date date-type="received"><day>27</day><month>5</month><year>2019</year></date><date date-type="rev-recd"><day>8</day><month>10</month><year>2019</year></date><date date-type="accepted"><day>19</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2020 Karishma Sharma et al.</copyright-statement><copyright-year>2020</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Kikuchi-Fujimoto disease (KFD) is a rare form of painful lymphadenopathy, usually cervical, which is more common in Southeast Asia and rarely reported from Africa. Symptoms are usually nonspecific (fever, night sweats, etc.), and can mimic more common diseases such as tuberculosis (TB) in endemic areas. We report a case of a 29-year-old black African woman who was admitted with headache, neck pain, fever, and lymphadenopathy. She was found to have aseptic meningitis, eventually attributed to TB based on cervical node biopsy, although further histology suggested KFD. Blood tests for systemic lupus erythematosus (SLE) were negative; she had already been commenced on anti-TB treatment and had responded well and so was continued with this therapy. She was also later diagnosed with Hashimoto's thyroiditis 3 months after her diagnosis of KFD. Five months after stopping TB treatment, she was readmitted with the same symptoms and associated painless lymphadenopathy. Repeat biopsy was morphologically similar to that of 2017, and repeat evaluation confirmed SLE. She has since been managed by a rheumatologist and continues to do well.</p></abstract></article-meta></front><body><sec id="sec1"><title>1. Introduction</title><p>Kikuchi-Fujimoto disease (KFD) is a rare form of painful lymphadenopathy which is more common in Southeast Asia. KFD is not very well described in Africa, with very few reports described in the literature. The lymphadenopathy is usually cervical with associated nonspecific symptoms of fever and night sweats, which makes the diagnosis more challenging as the differential diagnosis is wide. We describe a young female, who presented with aseptic meningitis initially thought to be due to tuberculous meningitis and later confirmed to have KFD on lymph node biopsy, and subsequently diagnosed with Hashimoto's thyroiditis and systemic lupus erythematosus (SLE) 3 and 18 months after initial presentation.</p></sec><sec id="sec2"><title>2. Case Presentation</title><p>A 29-year-old black African woman presented to the emergency department with headache and fever for 5 days. Brain imaging was normal, and lumbar puncture for cerebrospinal fluid (CSF) analysis showed a raised white cell count (WBC) of 31/mm<sup>3</sup> with 95% lymphocytosis, elevated CSF protein, and borderline high CSF adenine deaminase levels of 18.1 U/L. CSF Ziehl–Neelsen stain, GeneXpert, and culture for <italic>Mycobacterium tuberculosis</italic> (TB) were negative. Blood tests are in accordance with <xref rid="tab1" ref-type="table">Table 1</xref>. Her headache and fever resolved with oral paracetamol, and she was discharged with a diagnosis of aseptic meningitis.</p><p>However, she was readmitted with worsening neck pain and headache 2 weeks later and was found to have significantly enlarged cervical lymph nodes. Further evaluation with an MRI scan of the neck showed features in keeping with TB lymphadenitis. A repeat of laboratory workup (refer to <xref rid="tab1" ref-type="table">Table 1</xref>) remained negative. She also had a positive EBV IgG but with a negative serum IgM. A cervical lymph node was biopsied. Histopathological examination revealed necrotizing lymphadenitis with no granulomas (Figures <xref ref-type="fig" rid="fig1">1(a)</xref> and <xref ref-type="fig" rid="fig1">1(b)</xref>). Since the histologic appearance was indistinguishable from that of TB lymphadenitis, the patient was commenced on TB treatment (ATT) and was reviewed in a clinic 3 weeks later and found to have improved significantly.</p><p>The slides were sent for a second opinion overseas (USA), where the cervical biopsy was noted to show marked architectural effacement with large areas of necrosis containing abundant apoptotic debris. The adjacent viable areas contained numerous histiocytes, small lymphocytes, occasional plasma cells, and immunoblasts (Figures <xref ref-type="fig" rid="fig1">1(a)</xref> and <xref ref-type="fig" rid="fig1">1(b)</xref>). Hematoxylin bodies were not identified. Immunohistochemistry performed on the slides was CD20/PAX5 (B-cell marker)-positive, CD68 (histiocyte marker)-positive, and CD123 (plasmacytoid dendritic cells)-positive with a Ki of 67–60%.</p><p>These findings were in keeping with a diagnosis of histiocytic necrotizing lymphadenitis likely secondary to either KFD or SLE. However, given the patient was responding well to the TB therapy and she had screened negatively for SLE, she was continued on the treatment. Three months into her TB treatment, she was found to have an elevated thyroid stimulating hormone (TSH) of 47 pg/ml with low thyroxine and thyronine levels and positive antithyroid peroxidase and thyroglobulin antibodies in keeping with Hashimoto's thyroiditis. The patient completed 12 months of TB treatment and remained well and was discharged.</p><p>However, 5 months later, she presented to the infectious disease's clinic with a 1-month relapse of the same symptoms. She reported a history of travel to a malaria-endemic region 2 weeks prior and had taken a complete course of self-prescribed antimalarial medication with no resolution of symptoms. On examination, she had a temperature of 38°C but otherwise normal vital signs and large >1 cm bilateral nontender nonmatted upper cervical lymphadenopathy, but otherwise a normal physical examination with no meningism.</p><p>Investigations on this occasion are summarized in <xref rid="tab1" ref-type="table">Table 1</xref>.</p><p>Interestingly, the repeat autoimmune screen revealed ANA positive with titers of 1 : 320 and a speckled pattern. Her ENA anti-SS-A/RO-52 was also positive. The remainder of her evaluation was unremarkable except for persistent leucopenia, anemia, and thrombocytopenia.</p><p>She was reviewed by the rheumatologist and diagnosed as a case of systemic lupus erythematosus after she met 4 components of the SLICC criteria which included thrombocytopenia, leucopenia, arthritis, and positive ANA. Her Anti-Ro antibody was also positive and even though not part of the SLICC criteria is still in keeping with the diagnosis of SLE. While in hospital, her fevers settled spontaneously with antipyretics. At the time of discharge, she was initiated on prednisolone, azathioprine, and hydroxychloroquine which she is currently on and is asymptomatic. She currently remains on follow-up in the Rheumatology clinic.</p></sec><sec id="sec3"><title>3. Discussion</title><p>Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, was first described in 1972 [<xref rid="B1" ref-type="bibr">1</xref>]. It is a rare self-limiting lymphadenopathy, more commonly described in females, those aged 20–40 years and are of Southeast Asia origin [<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B3" ref-type="bibr">3</xref>]. Although less common within the African population, a few cases of the disease have been reported from Gabon, Senegal, Morocco, and Tunisia [<xref rid="B4" ref-type="bibr">4</xref>–<xref rid="B6" ref-type="bibr">6</xref>]. The disease affects both adults and children. The sex ratio is variable in the pediatric age group with males affected more than females, which is reversed in adults [<xref rid="B7" ref-type="bibr">7</xref>].</p><p>The exact pathophysiology of KFD is not known, but the two theories postulated are infectious and autoimmune etiology [<xref rid="B8" ref-type="bibr">8</xref>]. Xu et al. identified CMV,EBV, HHV-6, HHV-7, Parvovirus B19, and mycobacterial species from lymph node samples of 153 patients in China with KFD [<xref rid="B9" ref-type="bibr">9</xref>]. KFD has been described in association with SLE, Still's disease, Wegener's granulomatosis, Graves' disease, and Sjogren's disease [<xref rid="B3" ref-type="bibr">3</xref>]. Tanaka et al. found higher frequencies of the HLA DPA1<italic>∗</italic>01 and DPB1<italic>∗</italic>0202 allele in Japanese patients with KFD [<xref rid="B10" ref-type="bibr">10</xref>]. Familial cases of KFD have been reported in the literature [<xref rid="B11" ref-type="bibr">11</xref>].</p><p>The largest published series of 244 KFD cases has shown that fever (35%), fatigue (7%), and joint pain (7%) are the most frequent symptoms, and lymphadenopathy (100%), leucopenia (43%), high erythrocyte sedimentation rate (40%), anemia (23%), and erythematous rashes (10%) are the most common findings [<xref rid="B12" ref-type="bibr">12</xref>]. Our patient had high fever, lymphadenopathy, leukopenia, anemia, and high ESR. Cervical lymphadenopathy is the commonest site for lymphadenopathy and is usually painful [<xref rid="B13" ref-type="bibr">13</xref>].</p><p>The clinical picture of KFD is often nonspecific and can be in keeping with several diagnoses such as infectious mononucleosis, bacterial lymphadenitis (mainly tuberculosis which is highly endemic in Africa), malignant lymphoma, or metastatic cancer [<xref rid="B12" ref-type="bibr">12</xref>]. The nonspecific nature of presentation is associated with diagnostic delay and misdiagnosis of patients [<xref rid="B14" ref-type="bibr">14</xref>, <xref rid="B15" ref-type="bibr">15</xref>], especially in TB endemic regions such as Kenya, where patients get unnecessary ATT treatment.</p><p>Baenas et al. noted three patterns of presentation of association between KFD and SLE which are before the onset of SLE (30%), simultaneous occurrence of both disorders (47%), and KFD after SLE (23%) [<xref rid="B16" ref-type="bibr">16</xref>]. Goldblatt et al. reported 4 cases of patients who developed SLE after 4–13 months of diagnosis with KFD [<xref rid="B17" ref-type="bibr">17</xref>]. Since SLE evolves over many years and patients may not meet the diagnostic criteria at onset or in the initial phases of the disease, it is likely that the initial diagnosis of KFD in this patient may have been an attenuated form of SLE [<xref rid="B18" ref-type="bibr">18</xref>]. However, it remains difficult to reach this conclusion since the diagnosis is dependent on standard diagnostic criteria which our patient did not meet until much later in the disease. Interestingly, she has not had any flares of her disease following the initiation of her treatment for SLE, and it remains unclear whether her initial response to the anti-TB medication was more due to the steroids used in the treatment of CNS tuberculosis. Due to the association of KFD with SLE, follow-up and screening of patients with KFD for later diagnosis of SLE are recommended [<xref rid="B19" ref-type="bibr">19</xref>].</p><p>CNS manifestations of KFD are rare, and so far, aseptic meningitis, encephalitis, and cerebellar ataxia have been reported in the literature [<xref rid="B20" ref-type="bibr">20</xref>, <xref rid="B21" ref-type="bibr">21</xref>]. Aseptic meningitis is the commonest neurological presentation of Kikuchi's disease [<xref rid="B22" ref-type="bibr">22</xref>]. The CSF white cell count may range from 60 to 170 mm<sup>3</sup> and may present as recurrent meningitis within intervals of 1 month–11 years [<xref rid="B23" ref-type="bibr">23</xref>]. The diagnosis of KFD as a cause of the aseptic meningitis is made following exclusion of other potential reversible causes.</p><p>Hashimoto's thyroiditis has also been associated with Kikuchi disease. In majority of the cases, KFD and Hashimoto's thyroiditis occurred concurrently; however, in three cases, the diagnosis of Hashimoto's thyroiditis preceded that of KFD [<xref rid="B24" ref-type="bibr">24</xref>]. Previous reported cases note that it is more common in females and may be positive for ANA, complement, and antiphospholipid antibodies. Most reported cases complete resolution within a year following supportive care in some patients and steroids in others [<xref rid="B24" ref-type="bibr">24</xref>]. We came across a case report of a 17-year-old female with concurrent SLE and Hashimoto's thyroiditis who responded well to steroids and hydroxychloroquine. [<xref rid="B25" ref-type="bibr">25</xref>] Similarly, Aqel et al. reported a case of KFD in Saudi Arabia with Hashimoto's thyroiditis and mixed connective tissue disease [<xref rid="B26" ref-type="bibr">26</xref>].</p><p>The diagnosis of Kikuchi-Fujimoto disease is made on biopsy. Histologically, lymph nodes usually have partially preserved architecture with follicular hyperplasia. Necrotic foci show abundant karyorrhectic nuclear debris and a large accumulation of histiocytes at the edge of necrosis. The histiocytes in KFD are positive for lysozyme, myeloperoxidase, CD68, CD163, and CD4. The lymphocytes in the lesions are mostly CD3-positive T cells demonstrating a predominance of CD8 compared with CD4, with very few CD20-positive B cells [<xref rid="B3" ref-type="bibr">3</xref>]. In contrast, lymphadenitis from TB classically has the presence of well/poorly defined granulomas with areas of caseous necrosis [<xref rid="B27" ref-type="bibr">27</xref>]. The proliferative stage of KFD may be confused with lymphoma due to presence of large atypical cells and immunoblasts of T-cell lineage origin [<xref rid="B18" ref-type="bibr">18</xref>].</p><p>There is no consensus regarding treatment for this disease. Patients with mild disease respond to supportive care with antipyretics and NSAIDs. In contrast, those with extranodal disease with CNS and lung involvement may respond to short courses of corticosteroids [<xref rid="B28" ref-type="bibr">28</xref>].</p><p>During the first admission, the patient was on dexamethasone as part of her TB meningitis treatment. This could explain the initial resolution of her symptoms. Irrespective of the form of intervention, the prognosis of the condition is reported as favorable. However, there have been reported cases of death especially in patients who develop DIC [<xref rid="B29" ref-type="bibr">29</xref>].</p><p>Song et al. reported a higher incidence rate of relapse in ANA-positive cases and identified fever, fatigue, extranodal involvement, and positive fluorescence antinuclear antibody as predictive factors for relapse [<xref rid="B30" ref-type="bibr">30</xref>].</p><p>To the best of our knowledge, very few cases of this disorder have been reported so far from Africa. The challenges with making this diagnosis we believe are multiple including lack of clinician familiarity with disorder, few case reports, nonspecific signs and symptoms, poor laboratory support, and presence of alternative diagnosis especially tuberculosis in our set up.</p></sec></body><back><ack><title>Acknowledgments</title><p>We wish to thank Dr. Dilraj Singh Sokhi, Prof. Rodney Adam, Dr. Adil Salyani, Dr. Joseph Kiwinga, and the Pathology Department at the Aga Khan University Hospital for playing crucial roles in the diagnosis and management of this patient.</p></ack><sec><title>Consent</title><p>Written informed consent for publication of the clinical details and clinical images was obtained from the patient.</p></sec><sec sec-type="COI-statement"><title>Conflicts of Interest</title><p>The authors declare that they have no conflicts of interest.</p></sec><ref-list><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lame</surname><given-names>C.-A.</given-names></name><name><surname>Loum</surname><given-names>B.</given-names></name><name><surname>Fall</surname><given-names>A.-K.</given-names></name><name><surname>Cucherousset</surname><given-names>J.</given-names></name><name><surname>Ndiaye</surname><given-names>A.-R.</given-names></name></person-group><article-title>Kikuchi-Fujimoto disease, a rare cause of lymphadenopathy in Africa. 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(b) Lymph node biopsy 2017 (high-power view): numerous apoptotic bodies with histiocytes. (c) Lymph node biopsy 2019: numerous foci of necrosis with apoptotic bodies with scattered histiocytes. Absence of acute inflammatory infiltrate and hematoxylin bodies in keeping with Kikuchi's disease.</p></caption><graphic xlink:href="CRIM2020-4385286.001"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Laboratory results summarized from 2017 to 2019.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">Reference range</th><th align="center" rowspan="1" colspan="1">Aug 2017</th><th align="center" rowspan="1" colspan="1">Sept 2017</th><th align="center" rowspan="1" colspan="1">Jan 2018</th><th align="center" rowspan="1" colspan="1">July 2018</th><th align="center" rowspan="1" colspan="1">Feb 2019</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">White blood cell</td><td align="center" rowspan="1" colspan="1">4–10 (<italic>∗</italic>10<sup>9/L</sup>)</td><td align="center" rowspan="1" colspan="1">2.51</td><td align="center" rowspan="1" colspan="1">3.19</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">2.06</td></tr><tr><td align="left" rowspan="1" colspan="1">Neutrophil count</td><td align="center" rowspan="1" colspan="1">2–7 (<italic>∗</italic>10<sup>9/L</sup>)</td><td align="center" rowspan="1" colspan="1">1.16</td><td align="center" rowspan="1" colspan="1">2.12</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">1.14</td></tr><tr><td align="left" rowspan="1" colspan="1">Lymphocyte count</td><td align="center" rowspan="1" colspan="1">1–3 (<italic>∗</italic>10<sup>9/L</sup>)</td><td align="center" rowspan="1" colspan="1">1.10</td><td align="center" rowspan="1" colspan="1">0.81</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.80</td></tr><tr><td align="left" rowspan="1" colspan="1">Hemoglobin</td><td align="center" rowspan="1" colspan="1">11.5–16.5 (g/dl)</td><td align="center" rowspan="1" colspan="1">10.2</td><td align="center" rowspan="1" colspan="1">11</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">11</td></tr><tr><td align="left" rowspan="1" colspan="1">Platelet count</td><td align="center" rowspan="1" colspan="1">150–450 (<italic>∗</italic>10<sup>9/L</sup>)</td><td align="center" rowspan="1" colspan="1">118</td><td align="center" rowspan="1" colspan="1">153</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">85</td></tr><tr><td align="left" rowspan="1" colspan="1">ESR (Erythrocyte sedimentation rate)</td><td align="center" rowspan="1" colspan="1">0–20 (mm/hr)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">44</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">61</td></tr><tr><td align="left" rowspan="1" colspan="1">CRP (C-reactive protein)</td><td align="center" rowspan="1" colspan="1">0–5 (mg/l)</td><td align="center" rowspan="1" colspan="1">1.63</td><td align="center" rowspan="1" colspan="1">15.1</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">AST (aspartate transaminase)</td><td align="center" rowspan="1" colspan="1">0–35 (U/L)</td><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">23.5</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">33.4</td></tr><tr><td align="left" rowspan="1" colspan="1">ALT (alanine transaminase)</td><td align="center" rowspan="1" colspan="1">0–35 (U/L)</td><td align="center" rowspan="1" colspan="1">17.7</td><td align="center" rowspan="1" colspan="1">13.9</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">15.6</td></tr><tr><td align="left" rowspan="1" colspan="1">Creatinine</td><td align="center" rowspan="1" colspan="1">58–98 (micromol/l)</td><td align="center" rowspan="1" colspan="1">65</td><td align="center" rowspan="1" colspan="1">59</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">60</td></tr><tr><td align="left" rowspan="1" colspan="1">HIV Elisa</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">CSF:</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Cell count</td><td align="center" rowspan="1" colspan="1">0–5 (mm<sup>3</sup>)</td><td align="center" rowspan="1" colspan="1">31.25</td><td align="center" rowspan="1" colspan="1">295</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"><5</td></tr><tr><td align="left" rowspan="1" colspan="1">Neut</td><td align="center" rowspan="1" colspan="1">%</td><td align="center" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">4</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Lymph</td><td align="center" rowspan="1" colspan="1">%</td><td align="center" rowspan="1" colspan="1">94</td><td align="center" rowspan="1" colspan="1">96</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Glucose</td><td align="center" rowspan="1" colspan="1">2.22–3.89 (mmol/l)</td><td align="center" rowspan="1" colspan="1">2.39</td><td align="center" rowspan="1" colspan="1">3.51</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">2.69</td></tr><tr><td align="left" rowspan="1" colspan="1">Protein</td><td align="center" rowspan="1" colspan="1">0.15–0.45 (g/l)</td><td align="center" rowspan="1" colspan="1">0.52</td><td align="center" rowspan="1" colspan="1">0.56</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.44</td></tr><tr><td align="left" rowspan="1" colspan="1">Tb Gene expert</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td></tr><tr><td align="left" rowspan="1" colspan="1">CSF adenine deaminase</td><td align="center" rowspan="1" colspan="1">0–5 (U/L)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">18.41</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.29</td></tr><tr><td align="left" rowspan="1" colspan="1">CSF culture</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">No growth</td><td align="center" rowspan="1" colspan="1">No growth</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">No growth</td></tr><tr><td align="left" rowspan="1" colspan="1">CSF viral PCR-herpes + enterovirus</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td></tr><tr><td align="left" rowspan="1" colspan="1">EBV (Epstein-Barr virus)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">IgG-positive IgM-neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Tropical fever screen-<break></break>(i) Malaria antigen<break></break>(ii) Leptospira<break></break>(iii) Rickettsia<break></break>(iv) Dengue<break></break>(v) West Nile virus<break></break>(vi) Chikungunya</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td></tr><tr><td align="left" rowspan="1" colspan="1">Malaria parasite</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Absent</td><td align="center" rowspan="1" colspan="1">Absent</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Blood culture</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">No growth</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">No growth</td></tr><tr><td align="left" rowspan="1" colspan="1">Urine culture</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">No growth</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">No growth</td></tr><tr><td align="left" rowspan="1" colspan="1">ANA (antinuclear antibody)</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Positive 1 : 320 speckled</td></tr><tr><td align="left" rowspan="1" colspan="1">ENA</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Positive for SS-A/RO-52</td></tr><tr><td align="left" rowspan="1" colspan="1">Complement 3/4</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Normal</td></tr><tr><td align="left" rowspan="1" colspan="1">Anti-dsDNA</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td></tr><tr><td align="left" rowspan="1" colspan="1">Antiphospholipid antibody</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td></tr><tr><td align="left" rowspan="1" colspan="1">Direct Coombs test</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td></tr><tr><td align="left" rowspan="1" colspan="1">Ferritin</td><td align="center" rowspan="1" colspan="1">13–150 (ng/ml)</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Normal</td></tr><tr><td align="left" rowspan="1" colspan="1">Lipid profile</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Normal</td></tr><tr><td align="left" rowspan="1" colspan="1">TSH (thyroid stimulating hormone)</td><td align="center" rowspan="1" colspan="1">0.27–4.2 (pg/ml)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">1.68</td><td align="center" rowspan="1" colspan="1">49.77</td><td align="center" rowspan="1" colspan="1">25.24</td><td align="center" rowspan="1" colspan="1">4.23</td></tr><tr><td align="left" rowspan="1" colspan="1">T3</td><td align="center" rowspan="1" colspan="1">2–4.4 (pg/ml)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">2.88</td><td align="center" rowspan="1" colspan="1">1.67</td><td align="center" rowspan="1" colspan="1">2.97</td><td align="center" rowspan="1" colspan="1">1.87</td></tr><tr><td align="left" rowspan="1" colspan="1">T4</td><td align="center" rowspan="1" colspan="1">0.97–1.58 (ng/ml)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.87</td><td align="center" rowspan="1" colspan="1">0.32</td><td align="center" rowspan="1" colspan="1">0.84</td><td align="center" rowspan="1" colspan="1">0.86</td></tr><tr><td align="left" rowspan="1" colspan="1">Anti-TPO antibodies</td><td align="center" rowspan="1" colspan="1"><34 (IU/ml)</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">290</td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Antithyroglobulin</td><td align="center" rowspan="1" colspan="1"><115 (IU/ml)</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">226</td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">TSH receptor antibodies</td><td align="center" rowspan="1" colspan="1"><1.22</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.468</td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Lymph node biopsy</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Refer to Figures <xref ref-type="fig" rid="fig1">1(a)</xref> and <xref ref-type="fig" rid="fig1">1(b)</xref></td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Refer to <xref ref-type="fig" rid="fig1">Figure 1(c)</xref></td></tr><tr><td align="left" rowspan="1" colspan="1">Tissue Tb culture</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Neg</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Bone marrow aspirate</td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">Normocellular</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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