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Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer

Identifieur interne : 000A12 ( Pmc/Checkpoint ); précédent : 000A11; suivant : 000A13

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer

Auteurs : Sofia Avnet [Italie] ; Nicola Baldini [Italie] ; Lucie Brisson [France] ; Stine Falsig Pedersen [Danemark] ; Paolo E. Porporato [Italie] ; Pierre Sonveaux [Belgique] ; Gyorgy Szabadkai [Italie, Royaume-Uni] ; Silvia Pastorekova [Slovaquie]

Source :

RBID : PMC:6892776

Abstract

The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17–20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.


Url:
DOI: 10.3389/fonc.2019.01332
PubMed: 31850217
PubMed Central: 6892776


Affiliations:


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PMC:6892776

Le document en format XML

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<p>The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17–20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.</p>
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<name>
<surname>Avnet</surname>
<given-names>Sofia</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
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<name>
<surname>Baldini</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Brisson</surname>
<given-names>Lucie</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/525993/overview"></uri>
</contrib>
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<name>
<surname>Pedersen</surname>
<given-names>Stine Falsig</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/91326/overview"></uri>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Porporato</surname>
<given-names>Paolo E.</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/36457/overview"></uri>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sonveaux</surname>
<given-names>Pierre</given-names>
</name>
<xref ref-type="aff" rid="aff6">
<sup>6</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/11327/overview"></uri>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Szabadkai</surname>
<given-names>Gyorgy</given-names>
</name>
<xref ref-type="aff" rid="aff7">
<sup>7</sup>
</xref>
<xref ref-type="aff" rid="aff8">
<sup>8</sup>
</xref>
<xref ref-type="aff" rid="aff9">
<sup>9</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/31063/overview"></uri>
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<contrib contrib-type="author">
<name>
<surname>Pastorekova</surname>
<given-names>Silvia</given-names>
</name>
<xref ref-type="aff" rid="aff10">
<sup>10</sup>
</xref>
<xref ref-type="corresp" rid="c001">
<sup>*</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup></sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/33769/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1">
<sup>1</sup>
<institution>Orthopaedic Pathophysiology and Regenerative Medicine Unit, IRCCS Istituto Ortopedico Rizzoli</institution>
,
<addr-line>Bologna</addr-line>
,
<country>Italy</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Biomedical and Neuromotor Sciences, University of Bologna</institution>
,
<addr-line>Bologna</addr-line>
,
<country>Italy</country>
</aff>
<aff id="aff3">
<sup>3</sup>
<institution>INSERM UMR1069, Nutrition, Croissance et Cancer, University of Tours</institution>
,
<addr-line>Tours</addr-line>
,
<country>France</country>
</aff>
<aff id="aff4">
<sup>4</sup>
<institution>Department of Biology, Faculty of Science, University of Copenhagen</institution>
,
<addr-line>Copenhagen</addr-line>
,
<country>Denmark</country>
</aff>
<aff id="aff5">
<sup>5</sup>
<institution>Department of Molecular Biotechnology and Health Science, Molecular Biotechnology Center, University of Torino</institution>
,
<addr-line>Turin</addr-line>
,
<country>Italy</country>
</aff>
<aff id="aff6">
<sup>6</sup>
<institution>Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain</institution>
,
<addr-line>Brussels</addr-line>
,
<country>Belgium</country>
</aff>
<aff id="aff7">
<sup>7</sup>
<institution>Department of Biomedical Sciences, University of Padua</institution>
,
<addr-line>Padua</addr-line>
,
<country>Italy</country>
</aff>
<aff id="aff8">
<sup>8</sup>
<institution>Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London</institution>
,
<addr-line>London</addr-line>
,
<country>United Kingdom</country>
</aff>
<aff id="aff9">
<sup>9</sup>
<institution>The Francis Crick Institute</institution>
,
<addr-line>London</addr-line>
,
<country>United Kingdom</country>
</aff>
<aff id="aff10">
<sup>10</sup>
<institution>Biomedical Research Center, Slovak Academy of Sciences</institution>
,
<addr-line>Bratislava</addr-line>
,
<country>Slovakia</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>Edited by: Jaime Caro, Thomas Jefferson University, United States</p>
</fn>
<fn fn-type="edited-by">
<p>Reviewed by: Stephen John Ralph, Griffith Health, Griffith University, Australia; Cesare Indiveri, University of Calabria, Italy</p>
</fn>
<corresp id="c001">*Correspondence: Silvia Pastorekova
<email>virusipa@savba.sk</email>
</corresp>
<fn fn-type="other" id="fn001">
<p>This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology</p>
</fn>
<fn fn-type="other" id="fn002">
<p>†These authors have contributed equally to this work</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>28</day>
<month>11</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection">
<year>2019</year>
</pub-date>
<volume>9</volume>
<elocation-id>1332</elocation-id>
<history>
<date date-type="received">
<day>14</day>
<month>9</month>
<year>2019</year>
</date>
<date date-type="accepted">
<day>14</day>
<month>11</month>
<year>2019</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2019 Avnet, Baldini, Brisson, Pedersen, Porporato, Sonveaux, Szabadkai and Pastorekova.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Avnet, Baldini, Brisson, Pedersen, Porporato, Sonveaux, Szabadkai and Pastorekova</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<p>The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of metabolic enzymes and their upstream regulators and abnormal fluxes of metabolic intermediates and products. These attributes endow cancer cells with the ability to survive stressors of the tumor microenvironment and enable them to landscape and exploit the host terrain, thereby facilitating cancer progression and therapy resistance. Understanding the molecular and physiological principles of cancer metabolism is one of the key prerequisites for the development of better anticancer treatments. Therefore, various aspects of cancer metabolism were addressed at the 5th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Bratislava, Slovakia, on October 17–20, 2018. The meeting presentations and discussions were traditionally focused on mechanistic, translational, and clinical characteristics of metabolism and pH control in cancer, at the level of molecular pathways, cells, tissues, and organisms. In order to reflect major healthcare challenges of the current era, ISCaM has extended its scope to metabolic disorders contributing to cancer, as well as to opportunities for their prevention, intervention, and therapeutic targeting.</p>
</abstract>
<kwd-group>
<kwd>cancer metabolism</kwd>
<kwd>proton dynamics</kwd>
<kwd>tumor microenvironment</kwd>
<kwd>cancer imaging</kwd>
<kwd>cancer therapy</kwd>
</kwd-group>
<counts>
<fig-count count="0"></fig-count>
<table-count count="0"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="4"></ref-count>
<page-count count="5"></page-count>
<word-count count="3797"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations>
<list>
<country>
<li>Belgique</li>
<li>Danemark</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Slovaquie</li>
</country>
</list>
<tree>
<country name="Italie">
<noRegion>
<name sortKey="Avnet, Sofia" sort="Avnet, Sofia" uniqKey="Avnet S" first="Sofia" last="Avnet">Sofia Avnet</name>
</noRegion>
<name sortKey="Baldini, Nicola" sort="Baldini, Nicola" uniqKey="Baldini N" first="Nicola" last="Baldini">Nicola Baldini</name>
<name sortKey="Baldini, Nicola" sort="Baldini, Nicola" uniqKey="Baldini N" first="Nicola" last="Baldini">Nicola Baldini</name>
<name sortKey="Porporato, Paolo E" sort="Porporato, Paolo E" uniqKey="Porporato P" first="Paolo E." last="Porporato">Paolo E. Porporato</name>
<name sortKey="Szabadkai, Gyorgy" sort="Szabadkai, Gyorgy" uniqKey="Szabadkai G" first="Gyorgy" last="Szabadkai">Gyorgy Szabadkai</name>
</country>
<country name="France">
<noRegion>
<name sortKey="Brisson, Lucie" sort="Brisson, Lucie" uniqKey="Brisson L" first="Lucie" last="Brisson">Lucie Brisson</name>
</noRegion>
</country>
<country name="Danemark">
<noRegion>
<name sortKey="Pedersen, Stine Falsig" sort="Pedersen, Stine Falsig" uniqKey="Pedersen S" first="Stine Falsig" last="Pedersen">Stine Falsig Pedersen</name>
</noRegion>
</country>
<country name="Belgique">
<noRegion>
<name sortKey="Sonveaux, Pierre" sort="Sonveaux, Pierre" uniqKey="Sonveaux P" first="Pierre" last="Sonveaux">Pierre Sonveaux</name>
</noRegion>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Szabadkai, Gyorgy" sort="Szabadkai, Gyorgy" uniqKey="Szabadkai G" first="Gyorgy" last="Szabadkai">Gyorgy Szabadkai</name>
</noRegion>
<name sortKey="Szabadkai, Gyorgy" sort="Szabadkai, Gyorgy" uniqKey="Szabadkai G" first="Gyorgy" last="Szabadkai">Gyorgy Szabadkai</name>
</country>
<country name="Slovaquie">
<noRegion>
<name sortKey="Pastorekova, Silvia" sort="Pastorekova, Silvia" uniqKey="Pastorekova S" first="Silvia" last="Pastorekova">Silvia Pastorekova</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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