Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy
Identifieur interne : 000883 ( Pmc/Checkpoint ); précédent : 000882; suivant : 000884Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy
Auteurs : Liu-Qing Yang [République populaire de Chine] ; Ru-Yi Li [République populaire de Chine] ; Xi-Yan Yang [République populaire de Chine] ; Qian-Fei Cui [République populaire de Chine] ; Fei-Yun Wang [République populaire de Chine] ; Guo-Qiang Lin [République populaire de Chine] ; Jian-Ge Zhang [République populaire de Chine]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Effective delivery of chemotherapeutic agents to tumors is a critical objective of improved cancer therapy. Traditional antiangiogenic therapy aims at eradicating tumor blood vessels, but the subsequently reduced blood perfusion may limit the drug amount delivered into the tumor and potentially lead to tumor hypoxia, which has been proved to be unable to meet the therapeutic expectations. “Shexiang Baoxin Pill” (SBP) is a well-known traditional Chinese medicine (TCM) used in clinical treatment of cardiovascular diseases, which has the pharmacological effect of pro-angiogenesis demonstrated recently. In this study, we disclosed our finding that SBP could enhance the effective treatment performance of gemcitabine (GEM) while minimizing the toxic side effects caused by GEM. Mechanistically, SBP increased tumor angiogenesis, blood perfusion, vascular permeability, and vessel dilation, which subsequently favored the delivery of GEM to the tumor lesion. Moreover, combined treatment with SBP and GEM could modify tumor microenvironment and consequently overcome multidrug resistance, and this combination therapy is also suitable for combination of SBP with some other chemotherapeutic drugs as well. These results suggest that combining SBP with chemotherapeutic agents achieves better treatment efficiency, which can open an avenue for expanding the combined treatment of anti-cancer chemotherapeutic drugs with TCM.
Url:
DOI: 10.3389/fphar.2019.00565
PubMed: 31178734
PubMed Central: 6543272
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Effective delivery of chemotherapeutic agents to tumors is a critical objective of improved cancer therapy. Traditional antiangiogenic therapy aims at eradicating tumor blood vessels, but the subsequently reduced blood perfusion may limit the drug amount delivered into the tumor and potentially lead to tumor hypoxia, which has been proved to be unable to meet the therapeutic expectations. “Shexiang Baoxin Pill” (SBP) is a well-known traditional Chinese medicine (TCM) used in clinical treatment of cardiovascular diseases, which has the pharmacological effect of pro-angiogenesis demonstrated recently. In this study, we disclosed our finding that SBP could enhance the effective treatment performance of gemcitabine (GEM) while minimizing the toxic side effects caused by GEM. Mechanistically, SBP increased tumor angiogenesis, blood perfusion, vascular permeability, and vessel dilation, which subsequently favored the delivery of GEM to the tumor lesion. Moreover, combined treatment with SBP and GEM could modify tumor microenvironment and consequently overcome multidrug resistance, and this combination therapy is also suitable for combination of SBP with some other chemotherapeutic drugs as well. These results suggest that combining SBP with chemotherapeutic agents achieves better treatment efficiency, which can open an avenue for expanding the combined treatment of anti-cancer chemotherapeutic drugs with TCM.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Pharmacol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Pharmacol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Pharmacol.</journal-id>
<journal-title-group><journal-title>Frontiers in Pharmacology</journal-title>
</journal-title-group>
<issn pub-type="epub">1663-9812</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31178734</article-id>
<article-id pub-id-type="pmc">6543272</article-id>
<article-id pub-id-type="doi">10.3389/fphar.2019.00565</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pharmacology</subject>
<subj-group><subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Co-administration of Shexiang Baoxin Pill and Chemotherapy Drugs Potentiated Cancer Therapy by Vascular-Promoting Strategy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Liu-qing</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/687492/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Ru-yi</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Xi-yan</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cui</surname>
<given-names>Qian-fei</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Fei-yun</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lin</surname>
<given-names>Guo-qiang</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Jian-ge</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine</institution>
,<addr-line>Shanghai</addr-line>
,<country>China</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>School of Pharmaceutical Sciences, Zhengzhou University</institution>
,<addr-line>Zhengzhou</addr-line>
,<country>China</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Department of Respiratory and Critical Care Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University</institution>
,<addr-line>Changsha</addr-line>
,<country>China</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Ruiwen Zhang, University of Houston, United States</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Longfei Li, Shenzhen Zhongshan Urological Hospital, China; Dongmei Zhang, Jinan University, China; Zhe-Sheng Chen, St. John's University, United States</p>
</fn>
<corresp id="c001">*Correspondence: Jian-ge Zhang <email>jgzhang@shutcm.edu.cn</email>
</corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>24</day>
<month>5</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>10</volume>
<elocation-id>565</elocation-id>
<history><date date-type="received"><day>01</day>
<month>3</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>06</day>
<month>5</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2019 Yang, Li, Yang, Cui, Wang, Lin and Zhang.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Yang, Li, Yang, Cui, Wang, Lin and Zhang</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Effective delivery of chemotherapeutic agents to tumors is a critical objective of improved cancer therapy. Traditional antiangiogenic therapy aims at eradicating tumor blood vessels, but the subsequently reduced blood perfusion may limit the drug amount delivered into the tumor and potentially lead to tumor hypoxia, which has been proved to be unable to meet the therapeutic expectations. “Shexiang Baoxin Pill” (SBP) is a well-known traditional Chinese medicine (TCM) used in clinical treatment of cardiovascular diseases, which has the pharmacological effect of pro-angiogenesis demonstrated recently. In this study, we disclosed our finding that SBP could enhance the effective treatment performance of gemcitabine (GEM) while minimizing the toxic side effects caused by GEM. Mechanistically, SBP increased tumor angiogenesis, blood perfusion, vascular permeability, and vessel dilation, which subsequently favored the delivery of GEM to the tumor lesion. Moreover, combined treatment with SBP and GEM could modify tumor microenvironment and consequently overcome multidrug resistance, and this combination therapy is also suitable for combination of SBP with some other chemotherapeutic drugs as well. These results suggest that combining SBP with chemotherapeutic agents achieves better treatment efficiency, which can open an avenue for expanding the combined treatment of anti-cancer chemotherapeutic drugs with TCM.</p>
</abstract>
<kwd-group><kwd>cancer treatment</kwd>
<kwd>Shexiang Baoxin Pill</kwd>
<kwd>combination therapy</kwd>
<kwd>vascular promotion</kwd>
<kwd>drug delivery</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">National Natural Science Foundation of China<named-content content-type="fundref-id">10.13039/501100001809</named-content>
</funding-source>
</award-group>
<award-group><funding-source id="cn002">Science and Technology Commission of Shanghai Municipality<named-content content-type="fundref-id">10.13039/501100003399</named-content>
</funding-source>
</award-group>
</funding-group>
<counts><fig-count count="7"></fig-count>
<table-count count="1"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="49"></ref-count>
<page-count count="12"></page-count>
<word-count count="6764"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Liu Qing" sort="Yang, Liu Qing" uniqKey="Yang L" first="Liu-Qing" last="Yang">Liu-Qing Yang</name>
</noRegion>
<name sortKey="Cui, Qian Fei" sort="Cui, Qian Fei" uniqKey="Cui Q" first="Qian-Fei" last="Cui">Qian-Fei Cui</name>
<name sortKey="Li, Ru Yi" sort="Li, Ru Yi" uniqKey="Li R" first="Ru-Yi" last="Li">Ru-Yi Li</name>
<name sortKey="Lin, Guo Qiang" sort="Lin, Guo Qiang" uniqKey="Lin G" first="Guo-Qiang" last="Lin">Guo-Qiang Lin</name>
<name sortKey="Wang, Fei Yun" sort="Wang, Fei Yun" uniqKey="Wang F" first="Fei-Yun" last="Wang">Fei-Yun Wang</name>
<name sortKey="Yang, Liu Qing" sort="Yang, Liu Qing" uniqKey="Yang L" first="Liu-Qing" last="Yang">Liu-Qing Yang</name>
<name sortKey="Yang, Xi Yan" sort="Yang, Xi Yan" uniqKey="Yang X" first="Xi-Yan" last="Yang">Xi-Yan Yang</name>
<name sortKey="Zhang, Jian Ge" sort="Zhang, Jian Ge" uniqKey="Zhang J" first="Jian-Ge" last="Zhang">Jian-Ge Zhang</name>
</country>
</tree>
</affiliations>
</record>
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