Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis
Identifieur interne : 000844 ( Pmc/Checkpoint ); précédent : 000843; suivant : 000845Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis
Auteurs : Jun Wu [République populaire de Chine] ; Tian-Ping Zhang [République populaire de Chine] ; Yu-Lan Zhao [République populaire de Chine] ; Bao-Zhu Li [République populaire de Chine] ; Rui-Xue Leng [République populaire de Chine] ; Hai-Feng Pan [République populaire de Chine] ; Dong-Qing Ye [République populaire de Chine]Source :
- Biomolecules [ 2218-273X ] ; 2019.
Abstract
Long noncoding RNAs (lncRNAs) widely participate in human diseases by regulating gene transcription, modulating protein function, or acting as ceRNAs. Yet, their roles in rheumatoid arthritis (RA) remain obscure. In this study, the expression of three lncRNAs (H19, GAS5, and linc0597) in peripheral blood mononuclear cells (PBMCs) were detected in 77 RA patients and 78 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The association of lncRNAs related gene polymorphisms with RA were evaluated in 828 RA patients and 780 controls using TaqMan single nucleotide polymorphism (SNP) genotyping assays. We observed that the expression levels of H19, GAS5 and linc0597 were down-regulated in PBMCs of RA patients, of which GAS5 level decreased in patients with hypocomplementemia, and negatively correlated with C-reactive protein (CRP) level in RA patients. Moreover, we highlighted two related potential functional SNPs, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. The precise roles of these lncRNAs in mechanism of RA remain to be further explored.
Url:
DOI: 10.3390/biom10010055
PubMed: 31905737
PubMed Central: 7022387
Affiliations:
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(J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Pan, Hai Feng" sort="Pan, Hai Feng" uniqKey="Pan H" first="Hai-Feng" last="Pan">Hai-Feng Pan</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, 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last="Wu">Jun Wu</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Zhang, Tian Ping" sort="Zhang, Tian Ping" uniqKey="Zhang T" first="Tian-Ping" last="Zhang">Tian-Ping Zhang</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical 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Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Li, Bao Zhu" sort="Li, Bao Zhu" uniqKey="Li B" first="Bao-Zhu" last="Li">Bao-Zhu Li</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Leng, Rui Xue" sort="Leng, Rui Xue" uniqKey="Leng R" first="Rui-Xue" last="Leng">Rui-Xue Leng</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Pan, Hai Feng" sort="Pan, Hai Feng" uniqKey="Pan H" first="Hai-Feng" last="Pan">Hai-Feng Pan</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Ye, Dong Qing" sort="Ye, Dong Qing" uniqKey="Ye D" first="Dong-Qing" last="Ye">Dong-Qing Ye</name><affiliation><nlm:aff id="af1-biomolecules-10-00055">Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-10-00055">Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author></analytic><series><title level="j">Biomolecules</title><idno type="eISSN">2218-273X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Long noncoding RNAs (lncRNAs) widely participate in human diseases by regulating gene transcription, modulating protein function, or acting as ceRNAs. Yet, their roles in rheumatoid arthritis (RA) remain obscure. In this study, the expression of three lncRNAs (H19, GAS5, and linc0597) in peripheral blood mononuclear cells (PBMCs) were detected in 77 RA patients and 78 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The association of lncRNAs related gene polymorphisms with RA were evaluated in 828 RA patients and 780 controls using TaqMan single nucleotide polymorphism (SNP) genotyping assays. We observed that the expression levels of H19, GAS5 and linc0597 were down-regulated in PBMCs of RA patients, of which GAS5 level decreased in patients with hypocomplementemia, and negatively correlated with C-reactive protein (CRP) level in RA patients. Moreover, we highlighted two related potential functional SNPs, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. The precise roles of these lncRNAs in mechanism of RA remain to be further explored.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Scott, D L" uniqKey="Scott D">D.L. Scott</name></author><author><name sortKey="Wolfe, F" uniqKey="Wolfe F">F. Wolfe</name></author><author><name sortKey="Huizinga, T W" uniqKey="Huizinga T">T.W. Huizinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, T P" uniqKey="Zhang T">T.P. Zhang</name></author><author><name sortKey="Lv, T T" uniqKey="Lv T">T.T. Lv</name></author><author><name sortKey="Xu, S Z" uniqKey="Xu S">S.Z. Xu</name></author><author><name sortKey="Pan, H F" uniqKey="Pan H">H.F. Pan</name></author><author><name sortKey="Ye, D Q" uniqKey="Ye D">D.Q. Ye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prado, M G" uniqKey="Prado M">M.G. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomolecules</journal-id><journal-id journal-id-type="iso-abbrev">Biomolecules</journal-id><journal-id journal-id-type="publisher-id">biomolecules</journal-id><journal-title-group><journal-title>Biomolecules</journal-title></journal-title-group><issn pub-type="epub">2218-273X</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31905737</article-id><article-id pub-id-type="pmc">7022387</article-id><article-id pub-id-type="doi">10.3390/biom10010055</article-id><article-id pub-id-type="publisher-id">biomolecules-10-00055</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Decreased H19, GAS5, and linc0597 Expression and Association Analysis of Related Gene Polymorphisms in Rheumatoid Arthritis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Tian-Ping</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Yu-Lan</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Bao-Zhu</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-2453-5865</contrib-id><name><surname>Leng</surname><given-names>Rui-Xue</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref></contrib><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Hai-Feng</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref><xref rid="c1-biomolecules-10-00055" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Ye</surname><given-names>Dong-Qing</given-names></name><xref ref-type="aff" rid="af1-biomolecules-10-00055">1</xref><xref ref-type="aff" rid="af2-biomolecules-10-00055">2</xref><xref rid="c1-biomolecules-10-00055" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-biomolecules-10-00055"><label>1</label>Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, China;<email>wj1309230394@126.com</email> (J.W.);<email>15715511358@163.com</email> (T.-P.Z.);<email>dqjkzhao@126.com</email> (Y.-L.Z.);<email>libaozhu@ahmu.edu.cn</email> (B.-Z.L.);<email>lengruixue@ahmu.edu.cn</email> (R.-X.L.)</aff><aff id="af2-biomolecules-10-00055"><label>2</label>Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei 230032, China</aff><author-notes><corresp id="c1-biomolecules-10-00055"><label>*</label>Correspondence: <email>panhaifeng@ahmu.edu.cn</email> (H.-F.P.); <email>anhuiydq@126.com</email> (D.-Q.Y.); Tel.: +86-551-65161165 (H.-F.P.); +86-551-65167726 (D.-Q.Y.); Fax: +86-551-65161171 (H.-F.P.); +86-551-65167726 (D.-Q.Y.)</corresp></author-notes><pub-date pub-type="epub"><day>29</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="collection"><month>1</month><year>2020</year></pub-date><volume>10</volume><issue>1</issue><elocation-id>55</elocation-id><history><date date-type="received"><day>15</day><month>10</month><year>2019</year></date><date date-type="accepted"><day>26</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 by the authors.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Long noncoding RNAs (lncRNAs) widely participate in human diseases by regulating gene transcription, modulating protein function, or acting as ceRNAs. Yet, their roles in rheumatoid arthritis (RA) remain obscure. In this study, the expression of three lncRNAs (H19, GAS5, and linc0597) in peripheral blood mononuclear cells (PBMCs) were detected in 77 RA patients and 78 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The association of lncRNAs related gene polymorphisms with RA were evaluated in 828 RA patients and 780 controls using TaqMan single nucleotide polymorphism (SNP) genotyping assays. We observed that the expression levels of H19, GAS5 and linc0597 were down-regulated in PBMCs of RA patients, of which GAS5 level decreased in patients with hypocomplementemia, and negatively correlated with C-reactive protein (CRP) level in RA patients. Moreover, we highlighted two related potential functional SNPs, GAS5 rs6790 and linc0597 rs2680700 for associations with RA susceptibility. The precise roles of these lncRNAs in mechanism of RA remain to be further explored.</p></abstract><kwd-group><kwd>Rheumatoid arthritis</kwd><kwd>Long noncoding RNAs</kwd><kwd>Single nucleotide polymorphisms</kwd></kwd-group></article-meta></front><floats-group><fig id="biomolecules-10-00055-f001" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Comparison of GAS5, linc0597 and H19 expression levels in PBMCs between RA patients and controls. (<bold>a</bold>) Decreased GAS5 level in RA patients compared with controls; (<bold>b</bold>) Decreased linc0597 level in RA patients compared with controls; (<bold>c</bold>) Decreased H19 level in RA patients compared with controls. Data for lncRNAs expression levels were presented as median (interquartile range) (* <italic>p</italic> < 0.05, *** <italic>p</italic> < 0.001). RA, rheumatoid arthritis; HC, controls; PBMCs, peripheral blood mononuclear cells.</p></caption><graphic xlink:href="biomolecules-10-00055-g001"></graphic></fig><table-wrap id="biomolecules-10-00055-t001" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t001_Table 1</object-id><label>Table 1</label><caption><p>Primers used in real time quantitative PCR experiment.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">RNAs</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Primers</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">H19</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′TGCTGCACTTTACAACCACTG3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′ATGGTGTCTTTGATGTTGGGC3′</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">GAS5</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′TATGGTGCTGGGTGCGGAT3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′CCAATGGCTTGAGTTAGGCTT3′</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">linc0597</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′TTGGATTCATCCCGTTCACCTCCA3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′CAGCATGACGATCAAGCGAGATTC3′</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">β-actin</td><td align="center" valign="middle" rowspan="1" colspan="1">F:5′CACGAAACTACCTTCAACTCC3′</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">R:5′CATACTCCTGCTTGCTGATC3′</td></tr></tbody></table></table-wrap><table-wrap id="biomolecules-10-00055-t002" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t002_Table 2</object-id><label>Table 2</label><caption><p>Associations between lncRNAs expression and categorical laboratory parameters in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Parameters</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Number</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">GAS5</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">linc0597</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">H19</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">RF</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Positive</td><td align="center" valign="middle" rowspan="1" colspan="1">69</td><td align="center" valign="middle" rowspan="1" colspan="1">0.50 (0.34, 0.72)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.62 (0.47, 0.78)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.56 (0.35, 0.82)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Negative</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">8</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.52 (0.33, 0.92)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.54 (0.34, 0.86)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.57 (0.16, 1.18)</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Anti-CCP</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Positive</td><td align="center" valign="middle" rowspan="1" colspan="1">65</td><td align="center" valign="middle" rowspan="1" colspan="1">0.51 (0.35, 0.74)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.47, 0.79)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.35, 0.83)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Negative</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">12</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.34 (0.25, 0.77)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.63 (0.37, 0.73)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.36 (0.17, 0.74)</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Low complement</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Positive</td><td align="center" valign="middle" rowspan="1" colspan="1">14</td><td align="center" valign="middle" rowspan="1" colspan="1">0.35 (0.21, 0.46)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.50 (0.41, 0.69)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.52 (0.27, 1.23)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">Negative</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">52</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.53 (0.34, 0.77)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.62 (0.53, 0.80)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.60 (0.36, 0.82)</td></tr></tbody></table><table-wrap-foot><fn><p>Anti-CCP, anti-cyclic citrullinated peptide; RF, rheumatoid factor; RA, rheumatoid arthritis.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t003" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t003_Table 3</object-id><label>Table 3</label><caption><p>Correlations of lncRNAs expression with continuous laboratory parameters and degree of disease activity in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">Parameters</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">GAS5</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">linc0597</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">H19</th></tr><tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">ESR</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.072</td><td align="center" valign="middle" rowspan="1" colspan="1">0.535</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.114</td><td align="center" valign="middle" rowspan="1" colspan="1">0.325</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.150</td><td align="center" valign="middle" rowspan="1" colspan="1">0.196</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">CRP</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.273</td><td align="center" valign="middle" rowspan="1" colspan="1">0.017</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.096</td><td align="center" valign="middle" rowspan="1" colspan="1">0.411</td><td align="center" valign="middle" rowspan="1" colspan="1">0.002</td><td align="center" valign="middle" rowspan="1" colspan="1">0.986</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">TJC</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.020</td><td align="center" valign="middle" rowspan="1" colspan="1">0.866</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.091</td><td align="center" valign="middle" rowspan="1" colspan="1">0.435</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.192</td><td align="center" valign="middle" rowspan="1" colspan="1">0.097</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">SJC</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.054</td><td align="center" valign="middle" rowspan="1" colspan="1">0.648</td><td align="center" valign="middle" rowspan="1" colspan="1">0.052</td><td align="center" valign="middle" rowspan="1" colspan="1">0.660</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.110</td><td align="center" valign="middle" rowspan="1" colspan="1">0.924</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">DAS28-ESR</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.112</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.337</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.012</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.920</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.166</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.153</td></tr></tbody></table><table-wrap-foot><fn><p>DAS28-ESR, 28-joint disease activity score using erythrocyte sedimentation rate; CRP, C-reaction. protein; ESR, erythrocyte sedimentation rate; TJC, tender joint count; SJC, swollen joint count.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t004" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t004_Table 4</object-id><label>Table 4</label><caption><p>Influence of main clinical medication on lncRNAs expression in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Group</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Number</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">GAS5</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">linc0597</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">H19</th></tr></thead><tbody><tr><td colspan="2" align="center" valign="middle" rowspan="1">Prednisone (mg/day)</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">≤7.5</td><td align="center" valign="middle" rowspan="1" colspan="1">36</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.37, 0.94)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.46, 0.81)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.58 (0.30, 0.87)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">>7.5</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">37</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.42 (0.34, 0.68)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.62 (0.48, 0.78)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.55 (0.31, 0.82)</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">DMARDS</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td><td align="center" valign="middle" rowspan="1" colspan="1">44</td><td align="center" valign="middle" rowspan="1" colspan="1">0.51 (0.36, 0.81)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.62 (0.47, 0.78)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.61 (0.34, 0.84)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">No</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">29</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.53 (0.34, 0.69)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.59 (0.47, 0.80)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.43 (0.29, 0.84)</td></tr><tr><td colspan="2" align="center" valign="middle" rowspan="1">Botanical preparation</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td><td align="center" valign="middle" rowspan="1" colspan="1">22</td><td align="center" valign="middle" rowspan="1" colspan="1">0.51 (0.36, 0.84)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.63 (0.46, 0.82)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.59 (0.46, 1.13)</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">No</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">51</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.53 (0.34, 0.76)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.62 (0.48, 0.79)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.49 (0.27, 0.80)</td></tr></tbody></table><table-wrap-foot><fn><p>DMARDS, disease modifying antirheumatic drugs.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t005" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t005_Table 5</object-id><label>Table 5</label><caption><p>Allele and genotype frequencies of fourteen SNPs in RA patients and controls.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">SNPs</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">Analysis Model</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">RA <italic>n</italic>(%)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1">HC <italic>n</italic>(%)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>χ</italic><sup>2</sup></th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>OR</italic> (95% <italic>CI</italic>)</th><th align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic><sub>ad</sub><sub>just</sub> Value</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6790</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">362 (43.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">316 (40.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.103</td><td align="center" valign="middle" rowspan="1" colspan="1">0.848 (0.623–1.154)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.294</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA</td><td align="center" valign="middle" rowspan="1" colspan="1">333 (40.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">365 (47.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">6.132</td><td align="center" valign="middle" rowspan="1" colspan="1">0.679 (0.499–0.922)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.013</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">130 (15.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">94 (12.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1057 (63.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">997 (63.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.024</td><td align="center" valign="middle" rowspan="1" colspan="1">0.989 (0.856–1.142)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.877</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">593 (36.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">553 (36.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA + GA</td><td align="center" valign="middle" rowspan="1" colspan="1">463 (56.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">459 (59.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.630</td><td align="center" valign="middle" rowspan="1" colspan="1">0.878 (0.719–1.072)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.202</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">362 (43.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">316 (40.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">130 (15.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">94 (12.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">3.578</td><td align="center" valign="middle" rowspan="1" colspan="1">1.321 (0.990–1.762)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.059</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GA + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">695 (84.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">681 (87.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2067051</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotypes</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">101 (12.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">80 (10.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.059</td><td align="center" valign="middle" rowspan="1" colspan="1">1.189 (0.855–1.653)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.303</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TC</td><td align="center" valign="middle" rowspan="1" colspan="1">335 (41.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">306 (41.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.140</td><td align="center" valign="middle" rowspan="1" colspan="1">1.042 (0.842–1.289)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.708</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">380 (46.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">360 (48.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">T</td><td align="center" valign="middle" rowspan="1" colspan="1">537 (33.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">466 (31.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.998</td><td align="center" valign="middle" rowspan="1" colspan="1">1.080 (0.929–1.255)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.318</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1095 (67.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1026 (68.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT + TC</td><td align="center" valign="middle" rowspan="1" colspan="1">436 (53.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">386 (51.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.464</td><td align="center" valign="middle" rowspan="1" colspan="1">1.072 (0.878–1.130)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.496</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">380 (46.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">360 (48.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">101 (12.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">80 (10.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.923</td><td align="center" valign="middle" rowspan="1" colspan="1">1.167 (0.852–1.598)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.337</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TC + CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">715 (87.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">666 (89.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2070107</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">576 (69.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">549 (72.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.022</td><td align="center" valign="middle" rowspan="1" colspan="1">0.955 (0.522–1.747)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.881</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GC</td><td align="center" valign="middle" rowspan="1" colspan="1">233 (28.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">193 (25.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.089</td><td align="center" valign="middle" rowspan="1" colspan="1">1.100 (0.590–2.050)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.765</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">23 (2.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">21 (2.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1385(83.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1291(84.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.100</td><td align="center" valign="middle" rowspan="1" colspan="1">0.904 (0.748–1.092)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.294</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">279 (16.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">235 (15.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GC + CC</td><td align="center" valign="middle" rowspan="1" colspan="1">256 (30.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">214 (28.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.424</td><td align="center" valign="middle" rowspan="1" colspan="1">1.141 (0.919–1.418)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.233</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">576 (69.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">549 (72.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" rowspan="1" colspan="1">23 (2.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">21 (2.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.001</td><td align="center" valign="middle" rowspan="1" colspan="1">1.008(0.553–1.838)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.980</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GC + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">809 (97.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">742 (97.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2075745</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">113 (14.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">106 (14.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.080</td><td align="center" valign="middle" rowspan="1" colspan="1">0.956 (0.703–1.302)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.777</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TA</td><td align="center" valign="middle" rowspan="1" colspan="1">340 (42.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">318 (42.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.026</td><td align="center" valign="middle" rowspan="1" colspan="1">0.982 (0.791–1.219)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.871</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">350 (43.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">323 (43.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">T</td><td align="center" valign="middle" rowspan="1" colspan="1">566 (35.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">530 (35.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.018</td><td align="center" valign="middle" rowspan="1" colspan="1">0.990 (0.854–1.147)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.892</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1040 (64.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">964 (64.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT + TA</td><td align="center" valign="middle" rowspan="1" colspan="1">453 (56.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">424 (56.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.056</td><td align="center" valign="middle" rowspan="1" colspan="1">0.976 (0.797–1.194)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.812</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">350 (43.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">323 (43.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">113 (14.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">106 (14.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.058</td><td align="center" valign="middle" rowspan="1" colspan="1">0.965(0.722–1.289)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.809</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TA + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">690 (85.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">641 (85.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2285991</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">678 (86.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">612 (86.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.773</td><td align="center" valign="middle" rowspan="1" colspan="1">0.611 (0.203–1.834)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.379</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA</td><td align="center" valign="middle" rowspan="1" colspan="1">100 (12.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">90 (12.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.719</td><td align="center" valign="middle" rowspan="1" colspan="1">0.613 (0.198–1.900)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.396</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">9 (1.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">5 (0.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1456 (92.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1314 (92.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.199</td><td align="center" valign="middle" rowspan="1" colspan="1">0.939 (0.712–1.238)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.656</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">118 (7.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">100 (7.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA + AA</td><td align="center" valign="middle" rowspan="1" colspan="1">109 (13.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">95 (13.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.058</td><td align="center" valign="middle" rowspan="1" colspan="1">1.037 (0.770–1.397)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.809</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">678 (86.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">612 (86.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">9 (1.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">5 (0.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.772</td><td align="center" valign="middle" rowspan="1" colspan="1">1.637 (0.545–4.914)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.380</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GA + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">778 (98.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">702 (99.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2632516</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">270 (32.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">229 (29.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.151</td><td align="center" valign="middle" rowspan="1" colspan="1">1.161 (0.884–1.527)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.283</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GC</td><td align="center" valign="middle" rowspan="1" colspan="1">379 (45.8))</td><td align="center" valign="middle" rowspan="1" colspan="1">373 (47.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.015</td><td align="center" valign="middle" rowspan="1" colspan="1">1.016 (0.789–1.309)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.901</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">179 (21.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">178 (22.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">919 (55.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">831 (53.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.604</td><td align="center" valign="middle" rowspan="1" colspan="1">1.094 (0.952–1.257)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.205</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">737 (44.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">729 (46.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG + GC</td><td align="center" valign="middle" rowspan="1" colspan="1">649 (78.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">602 (77.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.329</td><td align="center" valign="middle" rowspan="1" colspan="1">1.072 (0.846–1.357)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.566</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">179 (21.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">178 (22.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">270 (32.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">229 (29.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.632</td><td align="center" valign="middle" rowspan="1" colspan="1">1.149 (0.928–1.422)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.201</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GC + CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">558 (67.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">551 (70.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2877877</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">50 (6.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">53 (7.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.270</td><td align="center" valign="middle" rowspan="1" colspan="1">0.790 (0.524–1.190)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.260</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GA</td><td align="center" valign="middle" rowspan="1" colspan="1">272 (33.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">248 (34.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.561</td><td align="center" valign="middle" rowspan="1" colspan="1">0.921 (0.741–1.143)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.454</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">500 (60.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">422 (58.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">372 (22.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">354 (24.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.470</td><td align="center" valign="middle" rowspan="1" colspan="1">0.902 (0.764–1.066)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.225</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">A</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1272 (77.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1092 (75.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG + GA</td><td align="center" valign="middle" rowspan="1" colspan="1">322 (39.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">301 (41.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.070</td><td align="center" valign="middle" rowspan="1" colspan="1">0.898 (0.731–1.101)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.301</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">500 (60.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">422 (58.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">50 (6.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">53 (7.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.006</td><td align="center" valign="middle" rowspan="1" colspan="1">0.814 (0.544–1.217)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.316</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GA + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">772 (93.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">670 (92.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs13414</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">368 (51.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">316 (46.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.149</td><td align="center" valign="middle" rowspan="1" colspan="1">1.076 (0.741–1.563)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.700</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG</td><td align="center" valign="middle" rowspan="1" colspan="1">283 (39.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">295 (43.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.403</td><td align="center" valign="middle" rowspan="1" colspan="1">0.885 (0.606–1.292)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.526</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">70 (9.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">65 (9.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">1019 (70.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">927 (68.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.456</td><td align="center" valign="middle" rowspan="1" colspan="1">1.104 (0.940–1.298)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.228</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">G</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">423 (29.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">425 (31.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG + GG</td><td align="center" valign="middle" rowspan="1" colspan="1">353 (49.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">360 (53.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2.551</td><td align="center" valign="middle" rowspan="1" colspan="1">0.841 (0.681–1.040)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.110</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">368 (51.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">316 (46.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">70 (9.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">65 (9.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.008</td><td align="center" valign="middle" rowspan="1" colspan="1">1.016 (0.710–1.455)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.930</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AG + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">651 (90.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">611 (90.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs4372750</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">168 (23.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">156 (23.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.184</td><td align="center" valign="middle" rowspan="1" colspan="1">1.070 (0.786–1.456)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.668</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AC</td><td align="center" valign="middle" rowspan="1" colspan="1">378 (52.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">352 (51.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.370</td><td align="center" valign="middle" rowspan="1" colspan="1">1.084 (0.836–1.405)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.543</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (23.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (25.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">714 (49.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">664 (49.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.222</td><td align="center" valign="middle" rowspan="1" colspan="1">1.036 (0.893–1.202)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.637</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">C</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">718 (50.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">692 (51.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA + AC</td><td align="center" valign="middle" rowspan="1" colspan="1">546 (76.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">508 (74.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.318</td><td align="center" valign="middle" rowspan="1" colspan="1">1.074 (0.839–1.374)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.573</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (23.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">170 (25.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">168 (23.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">156 (23.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.006</td><td align="center" valign="middle" rowspan="1" colspan="1">1.007 (0.999–1.015)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.937</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AC+CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">548 (76.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">522 (77.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs12601867</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" rowspan="1" colspan="1">165 (22.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">166 (24.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.953</td><td align="center" valign="middle" rowspan="1" colspan="1">0.860 (0.634–1.165)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.329</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CG</td><td align="center" valign="middle" rowspan="1" colspan="1">381 (52.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">361 (52.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.274</td><td align="center" valign="middle" rowspan="1" colspan="1">0.934 (0.723–1.206)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.601</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">185 (25.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">165 (23.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">C</td><td align="center" valign="middle" rowspan="1" colspan="1">711 (48.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">693 (50.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.590</td><td align="center" valign="middle" rowspan="1" colspan="1">0.944 (0.815–1.094)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.442</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">G</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">751 (51.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">691 (49.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">CG + GG</td><td align="center" valign="middle" rowspan="1" colspan="1">566 (77.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">526 (76.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.681</td><td align="center" valign="middle" rowspan="1" colspan="1">1.111 (0.866–1.425)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.409</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">165 (22.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">166 (24.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">185 (25.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">165 (23.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.571</td><td align="center" valign="middle" rowspan="1" colspan="1">1.098 (0.861–1.400)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.450</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">CG + CC</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">546 (74.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">527 (76.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs16847206</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">338 (46.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">296 (43.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.358</td><td align="center" valign="middle" rowspan="1" colspan="1">1.247 (0.860–1.808)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.244</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AT</td><td align="center" valign="middle" rowspan="1" colspan="1">325 (44.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">308 (45.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.679</td><td align="center" valign="middle" rowspan="1" colspan="1">1.169 (0.806–1.694)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.410</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">64 (8.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">73 (10.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">1001 (68.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">900 (66.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.808</td><td align="center" valign="middle" rowspan="1" colspan="1">1.115 (0.952–1.306)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.179</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">T</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">453 (31.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">454 (33.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AT + TT</td><td align="center" valign="middle" rowspan="1" colspan="1">389 (53.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">381 (56.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.735</td><td align="center" valign="middle" rowspan="1" colspan="1">0.911 (0.737–1.127)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.391</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">338 (46.5)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">296 (43.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">64 (8.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">73 (10.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.086</td><td align="center" valign="middle" rowspan="1" colspan="1">0.828 (0.581–1.180)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.297</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AT + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">663 (91.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">604 (89.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6692753</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">339 (46.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">287 (42.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.624</td><td align="center" valign="middle" rowspan="1" colspan="1">1.272 (0.878–1.843)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.203</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT</td><td align="center" valign="middle" rowspan="1" colspan="1">323 (44.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">323 (47.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.241</td><td align="center" valign="middle" rowspan="1" colspan="1">1.097 (0.758–1.587)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.623</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">65 (8.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">73 (10.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1001 (68.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">897 (65.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">3.231</td><td align="center" valign="middle" rowspan="1" colspan="1">1.155 (0.987–1.352)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.072</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">T</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">453 (31.2)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">469 (34.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT + TT</td><td align="center" valign="middle" rowspan="1" colspan="1">388 (53.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">396 (58.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">2.315</td><td align="center" valign="middle" rowspan="1" colspan="1">0.848 (0.686–1.049)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.128</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">339 (46.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">287 (42.0)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">65 (8.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">73 (10.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.842</td><td align="center" valign="middle" rowspan="1" colspan="1">0.848 (0.596–1.206)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.359</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GT + GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">662 (91.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">610 (89.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2680700</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">412 (57.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">376 (55.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1.773</td><td align="center" valign="middle" rowspan="1" colspan="1">0.755 (0.499–1.142)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.183</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT</td><td align="center" valign="middle" rowspan="1" colspan="1">243 (33.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">263 (38.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">4.477</td><td align="center" valign="middle" rowspan="1" colspan="1">0.630 (0.411–0.967)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.034</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">64 (8.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">43 (6.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">G</td><td align="center" valign="middle" rowspan="1" colspan="1">1067 (74.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1015 (74.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.017</td><td align="center" valign="middle" rowspan="1" colspan="1">0.989 (0.835–1.172)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.897</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">T</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">371 (25.8)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">349 (25.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GT + TT</td><td align="center" valign="middle" rowspan="1" colspan="1">307 (42.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">306 (44.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.857</td><td align="center" valign="middle" rowspan="1" colspan="1">0.904 (0.731–1.119)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.355</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">412 (57.3)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">376 (55.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">TT</td><td align="center" valign="middle" rowspan="1" colspan="1">64 (8.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">43 (6.3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2.896</td><td align="center" valign="middle" rowspan="1" colspan="1">1.421 (0.948–2.131)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.089</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GT+GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">655 (91.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">639 (93.7)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs8071916</td><td align="center" valign="middle" rowspan="1" colspan="1">Genotype</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" rowspan="1" colspan="1">175 (24.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">162 (23.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.016</td><td align="center" valign="middle" rowspan="1" colspan="1">1.020 (0.751–1.384)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.900</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG</td><td align="center" valign="middle" rowspan="1" colspan="1">378 (52.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">366 (53.0)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.015</td><td align="center" valign="middle" rowspan="1" colspan="1">0.984 (0.758–1.277)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.904</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">174 (23.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">163 (23.6)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">Allele</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">A</td><td align="center" valign="middle" rowspan="1" colspan="1">728 (50.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">690 (49.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.006</td><td align="center" valign="middle" rowspan="1" colspan="1">1.006 (0.868–1.165)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.940</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">G</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">726 (49.9)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">692 (50.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Dominant model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">AG + GG</td><td align="center" valign="middle" rowspan="1" colspan="1">552 (75.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">529 (76.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.059</td><td align="center" valign="middle" rowspan="1" colspan="1">0.970 (0.758–1.241)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.808</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">175 (24.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">162 (23.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td colspan="2" align="center" valign="middle" rowspan="1">Recessive model</td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1"></td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1"></td><td align="center" valign="middle" rowspan="1" colspan="1">GG</td><td align="center" valign="middle" rowspan="1" colspan="1">174 (23.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">163 (23.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.002</td><td align="center" valign="middle" rowspan="1" colspan="1">1.005 (0.785–1.287)</td><td align="center" valign="middle" rowspan="1" colspan="1">0.969</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">AG + AA</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">553 (76.1)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">528 (76.4)</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">1.000</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn><p>RA, rheumatoid arthritis; HC, control; OR, odds ratio; CI, confidence interval; SNPs, single nucleotide polymorphisms; <italic>p</italic><sub>adjust</sub>, <italic>p</italic> value adjusted for gender and age.</p></fn></table-wrap-foot></table-wrap><table-wrap id="biomolecules-10-00055-t006" orientation="portrait" position="float"><object-id pub-id-type="pii">biomolecules-10-00055-t006_Table 6</object-id><label>Table 6</label><caption><p>Correlations of lncRNAs expression levels with genotypes of gene single nucleotide polymorphisms in RA patients.</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" colspan="1">SNPs</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">GAS5</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">linc0597</th><th colspan="2" align="center" valign="middle" style="border-top:solid thin;border-bottom:solid thin" rowspan="1">H19</th></tr><tr><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>r<sub>s</sub></italic></th><th align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1"><italic>p</italic> Value</th></tr></thead><tbody><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2067051</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.030</td><td align="center" valign="middle" rowspan="1" colspan="1">0.823</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.076</td><td align="center" valign="middle" rowspan="1" colspan="1">0.569</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.011</td><td align="center" valign="middle" rowspan="1" colspan="1">0.935</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2075745</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.025</td><td align="center" valign="middle" rowspan="1" colspan="1">0.850</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.055</td><td align="center" valign="middle" rowspan="1" colspan="1">0.681</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.107</td><td align="center" valign="middle" rowspan="1" colspan="1">0.420</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2877877</td><td align="center" valign="middle" rowspan="1" colspan="1">0.085</td><td align="center" valign="middle" rowspan="1" colspan="1">0.523</td><td align="center" valign="middle" rowspan="1" colspan="1">0.088</td><td align="center" valign="middle" rowspan="1" colspan="1">0.509</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.031</td><td align="center" valign="middle" rowspan="1" colspan="1">0.815</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2070107</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.077</td><td align="center" valign="middle" rowspan="1" colspan="1">0.560</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.142</td><td align="center" valign="middle" rowspan="1" colspan="1">0.285</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.051</td><td align="center" valign="middle" rowspan="1" colspan="1">0.703</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2632516</td><td align="center" valign="middle" rowspan="1" colspan="1">0.096</td><td align="center" valign="middle" rowspan="1" colspan="1">0.470</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.094</td><td align="center" valign="middle" rowspan="1" colspan="1">0.478</td><td align="center" valign="middle" rowspan="1" colspan="1">0.031</td><td align="center" valign="middle" rowspan="1" colspan="1">0.816</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6790</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.941</td><td align="center" valign="middle" rowspan="1" colspan="1">0.029</td><td align="center" valign="middle" rowspan="1" colspan="1">0.828</td><td align="center" valign="middle" rowspan="1" colspan="1">0.068</td><td align="center" valign="middle" rowspan="1" colspan="1">0.611</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2285991</td><td align="center" valign="middle" rowspan="1" colspan="1">0.103</td><td align="center" valign="middle" rowspan="1" colspan="1">0.438</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.079</td><td align="center" valign="middle" rowspan="1" colspan="1">0.551</td><td align="center" valign="middle" rowspan="1" colspan="1">0.055</td><td align="center" valign="middle" rowspan="1" colspan="1">0.677</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs13414</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.149</td><td align="center" valign="middle" rowspan="1" colspan="1">0.360</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.041</td><td align="center" valign="middle" rowspan="1" colspan="1">0.803</td><td align="center" valign="middle" rowspan="1" colspan="1">0.014</td><td align="center" valign="middle" rowspan="1" colspan="1">0.930</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs4372750</td><td align="center" valign="middle" rowspan="1" colspan="1">0.344</td><td align="center" valign="middle" rowspan="1" colspan="1">0.030</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.950</td><td align="center" valign="middle" rowspan="1" colspan="1">0.202</td><td align="center" valign="middle" rowspan="1" colspan="1">0.211</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs12601867</td><td align="center" valign="middle" rowspan="1" colspan="1">0.216</td><td align="center" valign="middle" rowspan="1" colspan="1">0.180</td><td align="center" valign="middle" rowspan="1" colspan="1">0.010</td><td align="center" valign="middle" rowspan="1" colspan="1">0.950</td><td align="center" valign="middle" rowspan="1" colspan="1">0.244</td><td align="center" valign="middle" rowspan="1" colspan="1">0.129</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs16847206</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.135</td><td align="center" valign="middle" rowspan="1" colspan="1">0.414</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.090</td><td align="center" valign="middle" rowspan="1" colspan="1">0.588</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.136</td><td align="center" valign="middle" rowspan="1" colspan="1">0.408</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs6692753</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.143</td><td align="center" valign="middle" rowspan="1" colspan="1">0.378</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.100</td><td align="center" valign="middle" rowspan="1" colspan="1">0.538</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.145</td><td align="center" valign="middle" rowspan="1" colspan="1">0.373</td></tr><tr><td align="center" valign="middle" rowspan="1" colspan="1">rs2680700</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.149</td><td align="center" valign="middle" rowspan="1" colspan="1">0.358</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.135</td><td align="center" valign="middle" rowspan="1" colspan="1">0.406</td><td align="center" valign="middle" rowspan="1" colspan="1">−0.013</td><td align="center" valign="middle" rowspan="1" colspan="1">0.939</td></tr><tr><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">rs8071916</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.279</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.081</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.027</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.870</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">−0.250</td><td align="center" valign="middle" style="border-bottom:solid thin" rowspan="1" colspan="1">0.120</td></tr></tbody></table><table-wrap-foot><fn><p>SNPs, gene single nucleotide polymorphisms.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Anhui</li></region><settlement><li>Hefei</li></settlement></list><tree><country name="République populaire de Chine"><region name="Anhui"><name sortKey="Wu, Jun" sort="Wu, Jun" uniqKey="Wu J" first="Jun" last="Wu">Jun Wu</name></region><name sortKey="Leng, Rui Xue" sort="Leng, Rui Xue" uniqKey="Leng R" first="Rui-Xue" last="Leng">Rui-Xue Leng</name><name sortKey="Li, Bao Zhu" sort="Li, Bao Zhu" uniqKey="Li B" first="Bao-Zhu" last="Li">Bao-Zhu Li</name><name sortKey="Pan, Hai Feng" sort="Pan, Hai Feng" uniqKey="Pan H" first="Hai-Feng" last="Pan">Hai-Feng Pan</name><name sortKey="Ye, Dong Qing" sort="Ye, Dong Qing" uniqKey="Ye D" first="Dong-Qing" last="Ye">Dong-Qing Ye</name><name sortKey="Zhang, Tian Ping" sort="Zhang, Tian Ping" uniqKey="Zhang T" first="Tian-Ping" last="Zhang">Tian-Ping Zhang</name><name sortKey="Zhao, Yu Lan" sort="Zhao, Yu Lan" uniqKey="Zhao Y" first="Yu-Lan" last="Zhao">Yu-Lan Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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