HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness
Identifieur interne : 000727 ( Pmc/Checkpoint ); précédent : 000726; suivant : 000728HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness
Auteurs : David Kuo [États-Unis] ; Jennifer Ding [États-Unis] ; Ian S. Cohn [États-Unis] ; Fan Zhang [États-Unis] ; Kevin Wei [États-Unis] ; Deepak A. Rao [États-Unis] ; Cristina Rozo [États-Unis] ; Upneet K. Sokhi [États-Unis] ; Sara Shanaj [États-Unis] ; David J. Oliver [États-Unis] ; Adriana P. Echeverria [États-Unis] ; Edward F. Dicarlo [États-Unis] ; Michael B. Brenner [États-Unis] ; Vivian P. Bykerk [États-Unis] ; Susan M. Goodman [États-Unis] ; Soumya Raychaudhuri [États-Unis, Royaume-Uni] ; Gunnar R Tsch [Suisse, États-Unis] ; Lionel B. Ivashkiv [États-Unis] ; Laura T. Donlin [États-Unis]Source :
- Science translational medicine [ 1946-6234 ] ; 2019.
Url:
DOI: 10.1126/scitranslmed.aau8587
PubMed: 31068444
PubMed Central: 6726376
Affiliations:
- Royaume-Uni, Suisse, États-Unis
- Angleterre, Canton de Zurich, Grand Manchester
- Manchester, Zurich
- Université de Manchester
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Oliver</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Echeverria, Adriana P" sort="Echeverria, Adriana P" uniqKey="Echeverria A" first="Adriana P." last="Echeverria">Adriana P. Echeverria</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. 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Dicarlo</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Michael B" sort="Brenner, Michael B" uniqKey="Brenner M" first="Michael B." last="Brenner">Michael B. Brenner</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Goodman, Susan M" sort="Goodman, Susan M" uniqKey="Goodman S" first="Susan M." last="Goodman">Susan M. Goodman</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><affiliation wicri:level="1"><nlm:aff id="A4">Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A11">Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="R Tsch, Gunnar" sort="R Tsch, Gunnar" uniqKey="R Tsch G" first="Gunnar" last="R Tsch">Gunnar R Tsch</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Ivashkiv, Lionel B" sort="Ivashkiv, Lionel B" uniqKey="Ivashkiv L" first="Lionel B." last="Ivashkiv">Lionel B. Ivashkiv</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Graduate School of Medical Sciences, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Donlin, Laura T" sort="Donlin, Laura T" uniqKey="Donlin L" first="Laura T." last="Donlin">Laura T. Donlin</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31068444</idno><idno type="pmc">6726376</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726376</idno><idno type="RBID">PMC:6726376</idno><idno type="doi">10.1126/scitranslmed.aau8587</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000381</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000381</idno><idno type="wicri:Area/Pmc/Curation">000381</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000381</idno><idno type="wicri:Area/Pmc/Checkpoint">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000727</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HBEGF<sup>+</sup> macrophages in rheumatoid arthritis induce fibroblast invasiveness</title><author><name sortKey="Kuo, David" sort="Kuo, David" uniqKey="Kuo D" first="David" last="Kuo">David Kuo</name><affiliation wicri:level="1"><nlm:aff id="A1">Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Jennifer" sort="Ding, Jennifer" uniqKey="Ding J" first="Jennifer" last="Ding">Jennifer Ding</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Cohn, Ian S" sort="Cohn, Ian S" uniqKey="Cohn I" first="Ian S." last="Cohn">Ian S. Cohn</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><affiliation wicri:level="1"><nlm:aff id="A4">Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142</wicri:regionArea><wicri:noRegion>MA 02142</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Kevin" sort="Wei, Kevin" uniqKey="Wei K" first="Kevin" last="Wei">Kevin Wei</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Deepak A" sort="Rao, Deepak A" uniqKey="Rao D" first="Deepak A." last="Rao">Deepak A. Rao</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Rozo, Cristina" sort="Rozo, Cristina" uniqKey="Rozo C" first="Cristina" last="Rozo">Cristina Rozo</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Sokhi, Upneet K" sort="Sokhi, Upneet K" uniqKey="Sokhi U" first="Upneet K." last="Sokhi">Upneet K. Sokhi</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Shanaj, Sara" sort="Shanaj, Sara" uniqKey="Shanaj S" first="Sara" last="Shanaj">Sara Shanaj</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Oliver, David J" sort="Oliver, David J" uniqKey="Oliver D" first="David J." last="Oliver">David J. Oliver</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Echeverria, Adriana P" sort="Echeverria, Adriana P" uniqKey="Echeverria A" first="Adriana P." last="Echeverria">Adriana P. Echeverria</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Dicarlo, Edward F" sort="Dicarlo, Edward F" uniqKey="Dicarlo E" first="Edward F." last="Dicarlo">Edward F. Dicarlo</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Michael B" sort="Brenner, Michael B" uniqKey="Brenner M" first="Michael B." last="Brenner">Michael B. Brenner</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Goodman, Susan M" sort="Goodman, Susan M" uniqKey="Goodman S" first="Susan M." last="Goodman">Susan M. Goodman</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><affiliation wicri:level="1"><nlm:aff id="A4">Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A11">Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="R Tsch, Gunnar" sort="R Tsch, Gunnar" uniqKey="R Tsch G" first="Gunnar" last="R Tsch">Gunnar R Tsch</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065</wicri:regionArea><wicri:noRegion>NY 10065</wicri:noRegion></affiliation></author><author><name sortKey="Ivashkiv, Lionel B" sort="Ivashkiv, Lionel B" uniqKey="Ivashkiv L" first="Lionel B." last="Ivashkiv">Lionel B. Ivashkiv</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Graduate School of Medical Sciences, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author><author><name sortKey="Donlin, Laura T" sort="Donlin, Laura T" uniqKey="Donlin L" first="Laura T." last="Donlin">Laura T. Donlin</name><affiliation wicri:level="1"><nlm:aff id="A3">Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Weill Cornell Medical College, New York, NY 10021, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Weill Cornell Medical College, New York, NY 10021</wicri:regionArea><wicri:noRegion>NY 10021</wicri:noRegion></affiliation></author></analytic><series><title level="j">Science translational medicine</title><idno type="ISSN">1946-6234</idno><idno type="eISSN">1946-6242</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101505086</journal-id><journal-id journal-id-type="pubmed-jr-id">36963</journal-id><journal-id journal-id-type="nlm-ta">Sci Transl Med</journal-id><journal-id journal-id-type="iso-abbrev">Sci Transl Med</journal-id><journal-title-group><journal-title>Science translational medicine</journal-title></journal-title-group><issn pub-type="ppub">1946-6234</issn><issn pub-type="epub">1946-6242</issn></journal-meta><article-meta><article-id pub-id-type="pmid">31068444</article-id><article-id pub-id-type="pmc">6726376</article-id><article-id pub-id-type="doi">10.1126/scitranslmed.aau8587</article-id><article-id pub-id-type="manuscript">NIHMS1048452</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>HBEGF<sup>+</sup> macrophages in rheumatoid arthritis induce fibroblast invasiveness</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kuo</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref rid="FN3" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN1" ref-type="author-notes">†</xref><xref rid="FN3" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Cohn</surname><given-names>Ian S.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref rid="FN2" ref-type="author-notes">‡</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Fan</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Kevin</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>Deepak A.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Rozo</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sokhi</surname><given-names>Upneet K.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Shanaj</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Oliver</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Echeverria</surname><given-names>Adriana P.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>DiCarlo</surname><given-names>Edward F.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Michael B.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bykerk</surname><given-names>Vivian P.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Goodman</surname><given-names>Susan M.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Raychaudhuri</surname><given-names>Soumya</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Rätsch</surname><given-names>Gunnar</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ivashkiv</surname><given-names>Lionel B.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A13">13</xref><xref rid="FN4" ref-type="author-notes">§</xref></contrib><contrib contrib-type="author"><name><surname>Donlin</surname><given-names>Laura T.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A10">10</xref><xref rid="FN4" ref-type="author-notes">§</xref><xref rid="CR1" ref-type="corresp">‖</xref></contrib></contrib-group><aff id="A1"><label>1</label>Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.</aff><aff id="A2"><label>2</label>Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.</aff><aff id="A3"><label>3</label>Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.</aff><aff id="A4"><label>4</label>Center for Data Sciences, Brigham and Women’s Hospital, Boston, MA 02115, USA.</aff><aff id="A5"><label>5</label>Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.</aff><aff id="A6"><label>6</label>Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.</aff><aff id="A7"><label>7</label>Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.</aff><aff id="A8"><label>8</label>Division of Rheumatology, Immunology, Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.</aff><aff id="A9"><label>9</label>Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.</aff><aff id="A10"><label>10</label>Weill Cornell Medical College, New York, NY 10021, USA.</aff><aff id="A11"><label>11</label>Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, UK.</aff><aff id="A12"><label>12</label>Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich, Switzerland</aff><aff id="A13"><label>13</label>Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.</aff><author-notes><fn fn-type="present-address" id="FN1"><label>†</label><p id="P1">Present address: Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.</p></fn><fn fn-type="present-address" id="FN2"><label>‡</label><p id="P2">Present address: Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</p></fn><fn fn-type="other" id="FN3"><label>*</label><p id="P3">Co-first authors.</p></fn><fn fn-type="other" id="FN4"><label>§</label><p id="P4">Co-senior authors.</p></fn><fn fn-type="con" id="FN5"><p id="P5">Author contributions:</p><p id="P6">D.K. analyzed sequencing data, prepared figures, and edited the manuscript; J.D. performed experiments and analyzed data; I.S.C. performed experiments and prepared figures; F.Z. analyzed AMP sequencing data and advised on incorporating it into this manuscript; K.W. and D.A.R. designed experimental pipelines and performed experiments; U.K.S., C.R., and S.S. performed experiments; D.J.O. and A.P.E. analyzed sequencing data; AMP recruited patients and performed experiments; E.F.D. scored histology slides; M.B.B. designed and supervised the AMP experimental pipeline; V.P.B. and S.M.G. collected clinical data and samples; S.R. supervised analysis of AMP sequencing data and incorporated it into this manuscript; G.R. supervised analysis of the in vitro and ex vivo sequencing data; L.B.I. jointly conceived the project, oversaw the in vitro coculture experiments, acquired funding, and edited the manuscript; L.T.D. jointly conceived the project, acquired funding, oversaw the in vitro coculture and RA tissue ex vivo assays, wrote the manuscript, and supervised the research experiments and analyses.</p></fn><corresp id="CR1"><label>‖</label> Corresponding author. <email>donlinl@hss.edu</email></corresp><fn fn-type="COI-statement" id="FN8"><p id="P63">Competing interests:</p><p id="P64">M.B.B. serves on a scientific advisory board for GlaxoSmithKline and receives royalties from Roche. D.K. is an employee of Juno Therapeutics, a Celgene Company. The other authors declare that they have no competing interests to declare.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>8</month><year>2019</year></pub-date><pub-date pub-type="ppub"><day>08</day><month>5</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>9</month><year>2019</year></pub-date><volume>11</volume><issue>491</issue><elocation-id>eaau8587</elocation-id></article-meta></front></pmc><affiliations><list><country><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Canton de Zurich</li><li>Grand Manchester</li></region><settlement><li>Manchester</li><li>Zurich</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Kuo, David" sort="Kuo, David" uniqKey="Kuo D" first="David" last="Kuo">David Kuo</name></noRegion><name sortKey="Brenner, Michael B" sort="Brenner, Michael B" uniqKey="Brenner M" first="Michael B." last="Brenner">Michael B. Brenner</name><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><name sortKey="Cohn, Ian S" sort="Cohn, Ian S" uniqKey="Cohn I" first="Ian S." last="Cohn">Ian S. Cohn</name><name sortKey="Dicarlo, Edward F" sort="Dicarlo, Edward F" uniqKey="Dicarlo E" first="Edward F." last="Dicarlo">Edward F. Dicarlo</name><name sortKey="Ding, Jennifer" sort="Ding, Jennifer" uniqKey="Ding J" first="Jennifer" last="Ding">Jennifer Ding</name><name sortKey="Donlin, Laura T" sort="Donlin, Laura T" uniqKey="Donlin L" first="Laura T." last="Donlin">Laura T. Donlin</name><name sortKey="Donlin, Laura T" sort="Donlin, Laura T" uniqKey="Donlin L" first="Laura T." last="Donlin">Laura T. Donlin</name><name sortKey="Echeverria, Adriana P" sort="Echeverria, Adriana P" uniqKey="Echeverria A" first="Adriana P." last="Echeverria">Adriana P. Echeverria</name><name sortKey="Goodman, Susan M" sort="Goodman, Susan M" uniqKey="Goodman S" first="Susan M." last="Goodman">Susan M. Goodman</name><name sortKey="Goodman, Susan M" sort="Goodman, Susan M" uniqKey="Goodman S" first="Susan M." last="Goodman">Susan M. Goodman</name><name sortKey="Ivashkiv, Lionel B" sort="Ivashkiv, Lionel B" uniqKey="Ivashkiv L" first="Lionel B." last="Ivashkiv">Lionel B. Ivashkiv</name><name sortKey="Ivashkiv, Lionel B" sort="Ivashkiv, Lionel B" uniqKey="Ivashkiv L" first="Lionel B." last="Ivashkiv">Lionel B. Ivashkiv</name><name sortKey="Ivashkiv, Lionel B" sort="Ivashkiv, Lionel B" uniqKey="Ivashkiv L" first="Lionel B." last="Ivashkiv">Lionel B. Ivashkiv</name><name sortKey="Kuo, David" sort="Kuo, David" uniqKey="Kuo D" first="David" last="Kuo">David Kuo</name><name sortKey="Oliver, David J" sort="Oliver, David J" uniqKey="Oliver D" first="David J." last="Oliver">David J. Oliver</name><name sortKey="R Tsch, Gunnar" sort="R Tsch, Gunnar" uniqKey="R Tsch G" first="Gunnar" last="R Tsch">Gunnar R Tsch</name><name sortKey="Rao, Deepak A" sort="Rao, Deepak A" uniqKey="Rao D" first="Deepak A." last="Rao">Deepak A. Rao</name><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name><name sortKey="Rozo, Cristina" sort="Rozo, Cristina" uniqKey="Rozo C" first="Cristina" last="Rozo">Cristina Rozo</name><name sortKey="Shanaj, Sara" sort="Shanaj, Sara" uniqKey="Shanaj S" first="Sara" last="Shanaj">Sara Shanaj</name><name sortKey="Sokhi, Upneet K" sort="Sokhi, Upneet K" uniqKey="Sokhi U" first="Upneet K." last="Sokhi">Upneet K. Sokhi</name><name sortKey="Wei, Kevin" sort="Wei, Kevin" uniqKey="Wei K" first="Kevin" last="Wei">Kevin Wei</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Raychaudhuri, Soumya" sort="Raychaudhuri, Soumya" uniqKey="Raychaudhuri S" first="Soumya" last="Raychaudhuri">Soumya Raychaudhuri</name></region></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="R Tsch, Gunnar" sort="R Tsch, Gunnar" uniqKey="R Tsch G" first="Gunnar" last="R Tsch">Gunnar R Tsch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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